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ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

100301568

KEGG Gene ID

rno:100301568

PubChem

100301568

Alliance of Genome Resources

RGD:2307241

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8CFC4	B blood group galactosyltransferase Blood group A glycosyltransferase 2 Cis-AB transferase 2 Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-galactosyltransferase Histo-blood group A transferase Histo-blood group B transferase NAGAT 2 Putative blood group A transferase T2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IMP	12499407
protein glycosylation	IEA
response to nematode	IEP	11842091

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

lipid glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to nematode

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to nematode

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to nematode

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to retinoic acid

response to oxygen-containing compound [inference]

response to retinoic acid

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
vesicle	IBA
extracellular region	IEA
membrane	IEA
Golgi apparatus	IBA
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
hexosyltransferase activity	IEA
antigen binding	ISO
alpha-1,3-galactosyltransferase activity	IDA	12626403
manganese ion binding	ISO
fucosylgalactoside 3-alpha-galactosyltransferase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

hexosyltransferase activity

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

galactosyltransferase activity [inference]

alpha-1,3-galactosyltransferase activity

UDP-galactosyltransferase activity [inference]

beta-1,3-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

binding [inference]

antigen binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00709

Name

histo-blood group ABO system transferase [EC:2.4.1.40 2.4.1.37]

References

12180981

Reactions

Displaying **all 9** entries
KEGG Reaction	Enzyme	Acceptor	Product
R06190	2.4.1.37	G66427ZQ	G47614ZH
R06187	2.4.1.40	G13636IT	G96538JO
R13171	2.4.1.40	G98465JN	G37830TX
R06193	2.4.1.40	G66427ZQ	G46461VY
R06191	2.4.1.40	G59724US	G20578GS
R06168	2.4.1.37	G00050MO	G63238VS
R06197	2.4.1.40	G58990QD	G51661GQ
R06167	2.4.1.40	G00050MO	G82858KU
R06029	2.4.1.37	G13636IT	G77593JU

Rhea

RHEA:14349

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-α-D-galactose

an α-D-galactosyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.37

PMID

RHEA:19021

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-N-acetyl-α-D-galactosamine

an N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.40

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1240	leukemia	Alliance of Genome Resources
DOID:13406	pulmonary sarcoidosis	Alliance of Genome Resources
DOID:14067	Plasmodium falciparum malaria	Alliance of Genome Resources
DOID:1496	echinococcosis	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2237	hepatitis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP013649
Gene Name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)

Ortholog

Displaying entries **21 - 24** of 24 in total

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Species	Gene ID	Orthologous MAtrix
Chlorocebus sabaeus	103239700	CHLSB02930
Rhinopithecus bieti	108513461	RHIBE14653
Nannospalax galili	103740691	NANGA26747
Carlito syrichta	103250932	CARSF19150

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements