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MHC class I polypeptide-related sequence A
Summary
- Gene Symbol
-
- MICA
- Aliases
-
- PERB11.1
- Organism
- Homo sapiens (human)
External Links
- NCBI Gene
- 100507436
- HGNC
- 7090
- KEGG Gene ID
- hsa:100507436
- PubChem
- 100507436
- Alliance of Genome Resources
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative splicing
- Cell membrane
- Cytolysis
- Cytoplasm
- Disulfide bond
- Glycoprotein
- Host-virus interaction
- Immunoglobulin domain
- Metal-binding
- Palmitate
- Proteomics identification
- Reference proteome
- Signal
- Transmembrane helix
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q29983 |
|
| Q96QC4 |
|
| A0A0G2JJ55 |
|
| A0A024RCL3 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| signal transduction | ||
| T cell mediated cytotoxicity | ||
| negative regulation of natural killer cell activation | ||
| positive regulation of T cell mediated cytotoxicity | ||
| negative regulation of natural killer cell mediated cytotoxicity |
GO Hierarchy
biological process
immune system process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasm | ||
| external side of plasma membrane | ||
| cell surface | ||
| plasma membrane | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| signaling receptor binding | ||
| peptide antigen binding | ||
| natural killer cell lectin-like receptor binding | ||
| receptor ligand activity | ||
| protein binding |
GO Hierarchy
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110458 | dilated cardiomyopathy 1BB | |
| DOID:0110459 | dilated cardiomyopathy 1FF | |
| DOID:0110460 | dilated cardiomyopathy 2A | |
| DOID:0110461 | X-linked dilated cardiomyopathy | |
| DOID:0110741 | type 1 diabetes mellitus 2 | |
| DOID:0110742 | type 1 diabetes mellitus 3 | |
| DOID:0110743 | type 1 diabetes mellitus 4 | |
| DOID:0110744 | type 1 diabetes mellitus 5 | |
| DOID:0110745 | type 1 diabetes mellitus 6 | |
| DOID:0110746 | type 1 diabetes mellitus 7 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100148359 | ZFIN:ZDB-GENE-140820-7 | ||
| 100390841 | CALJA31676 | ||
| 715141 | MACMU33951 | ||
| 100141395 | MACMU33951 | ||
| 450199 | PANTR37676 | ||
| 100438364 | PONAB31024 | ||
| 100444949 | PONAB31035 | ||
| 243864 | MGI:2179989 | MOUSE52922 | |
| 266815 | MGI:2179988 | MOUSE52826 | |
| 292671 | RGD:1311714 | RATNO19320 |
