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carboxyl ester lipase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1056

KEGG Gene ID

hsa:1056

PubChem

1056

Alliance of Genome Resources

HGNC:1848

Annotation

Keyword

Hydrolase
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DSX9
O75612
Q86SR3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
intestinal cholesterol absorption	IDA	12031288
lipid metabolic process		8639615
ceramide catabolic process	IBA
pancreatic juice secretion	IBA IDA	1854805
retinol metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

pancreatic juice secretion

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

secretion by tissue [inference]

pancreatic juice secretion

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intestinal cholesterol absorption

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intestinal cholesterol absorption

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

regulation of body fluid levels [inference]

body fluid secretion [inference]

pancreatic juice secretion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region
cytoplasm	ISS
extracellular space	HDA	16502470
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
catalytic activity		2265692
hydrolase activity		2265692
heparin binding		7578248
acetylesterase activity	IEA
sterol esterase activity	IBA NAS	12031288

GO Hierarchy

molecular function

catalytic activity

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

carboxylic ester hydrolase activity [inference]

short-chain carboxylesterase activity [inference]

acetylesterase activity

retinyl-palmitate esterase activity

binding [inference]

protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000170835

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12298

Name

bile salt-stimulated lipase [EC:3.1.1.3 3.1.1.13]

References

Disease

Disease Ontology

Displaying entries **71 - 80** of **167** in total

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DO ID	Disease Name	Source
DOID:2237	hepatitis	DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET DisGeNET DisGeNET
DOID:2349	arteriosclerosis	DisGeNET DisGeNET
DOID:2508	Takayasu's arteritis	DisGeNET
DOID:2527	nephrosis	DisGeNET
DOID:2531	hematologic cancer	DisGeNET
DOID:26	pancreas disease	DisGeNET
DOID:2797	idiopathic interstitial pneumonia	DisGeNET DisGeNET
DOID:2841	asthma	DisGeNET DisGeNET
DOID:2913	acute pancreatitis	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 20** of 25 in total

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HPO ID	HPO Term
HP:0001513	Obesity
HP:0001520	Large for gestational age
HP:0001738	Exocrine pancreatic insufficiency
HP:0001952	Glucose intolerance
HP:0001953	Diabetic ketoacidosis
HP:0001998	Neonatal hypoglycemia
HP:0002027	Abdominal pain
HP:0002594	Pancreatic hypoplasia
HP:0003074	Hyperglycemia
HP:0003076	Glycosuria

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:609812	maturity-onset diabetes of the young type 8
ORPHA:552	maturity-onset diabetes of the young

PubChem Disease

MedGen Diseases

Maturity-onset diabetes of the young type 8

OMIM Phenotypes

MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION; MODY8

KEGG Diseases

Maturity onset diabetes of the young (MODY)

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001787
Gene Name: carboxyl ester lipase

Ortholog

Displaying entries **11 - 20** of 92 in total

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Species	Gene ID	Orthologous MAtrix
Salmo trutta	115204132	SALTR79222
Gadus morhua	115532295	GADMO25853
Gadus morhua	115532524	GADMO25853
Xiphophorus maculatus	102226098	XIPMA33747
Xiphophorus maculatus	102226868	XIPMA33745
Oryzias latipes	101172916	ORYLA02953
Oreochromis niloticus	100703411	ORENI67295
Oreochromis niloticus	109199076	ORENI67425
Oreochromis niloticus	109199077	ORENI67466
Haplochromis burtoni	102305033	HAPBU24025

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements