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complement component 1, q subcomponent, alpha polypeptide

Summary

Gene Symbol

C1qa

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12259

PubChem

12259

Alliance of Genome Resources

MGI:88223

Annotation

Keyword

Collagen
Complement pathway
Disulfide bond
Glycoprotein
Hydroxylation
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A3B0IP04
P98086

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
innate immune response	IEA
astrocyte activation	IGI	15269255
synapse organization	IGI	27033548
synapse pruning	IGI	27033548
complement-mediated synapse pruning	IMP	18083105

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, classical pathway

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

glial cell activation [inference]

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

cell junction disassembly [inference]

synapse pruning

complement-mediated synapse pruning

cell junction organization [inference]

synapse organization

synapse pruning

complement-mediated synapse pruning

cell junction disassembly [inference]

synapse pruning

complement-mediated synapse pruning

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

glial cell activation [inference]

pattern specification process [inference]

regionalization [inference]

vertebrate eye-specific patterning

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	NAS	28104818
collagen trimer	IEA
complement component C1 complex	NAS	28104818
extracellular space	HDA	24006456

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

cell junction [inference]

synapse

glutamatergic synapse

postsynapse

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	22682250

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement c1q subcomponent subunit a

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
InterPro
C1q domain
Collagen triple helix repeat
Tumour necrosis factor-like domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 54 in total

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Species	Gene ID	Orthologous MAtrix
Pongo abelii	100433850	PONAB16853
Ailuropoda melanoleuca	100465747	AILME12476
Meleagris gallopavo	100546926	MELGA07667
Anolis carolinensis	100556677	ANOCA09394
Nomascus leucogenys	100606692	NOMLE23483
Loxodonta africana	100664959	LOXAF08971
Cavia porcellus	100724576	CAVPO12060
Cricetulus griseus	100766409	CRIGR11665
Saimiri boliviensis boliviensis	101048882	SAIBB24435
Felis catus	101096082	FELCA19757

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements