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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
catechol-O-methyltransferase
Summary
- Gene Symbol
-
- COMT
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Catecholamine metabolism
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- Magnesium
- Metal-binding
- Methyltransferase
- Neurotransmitter degradation
- Phosphoprotein
- Reference proteome
- S-adenosyl-L-methionine
- Schizophrenia
- Signal-anchor
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P21964 |
|
| A0A140VJG8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to oxidative stress | ||
| cellular response to phosphate starvation | ||
| methylation | ||
| visual learning | ||
| response to wounding |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| L-dopa O-methyltransferase activity |
|
|
| orcinol O-methyltransferase activity |
|
|
| protein binding | ||
| catechol O-methyltransferase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060402 | chromosome 17p13.1 deletion syndrome | |
| DOID:0060668 | anencephaly | |
| DOID:0060776 | congenital diarrhea 5 with tufting enteropathy | |
| DOID:0060877 | bullous congenital ichthyosiform erythroderma | |
| DOID:0060888 | transient myeloproliferative syndrome | |
| DOID:0060891 | Parkinson's disease 19A | |
| DOID:0060892 | late onset Parkinson's disease | |
| DOID:0060895 | Parkinson's disease 4 | |
| DOID:0060896 | Parkinson's disease 23 | |
| DOID:0080016 | spina bifida |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0005562 | Multiple renal cysts |
| HP:0006510 | Chronic pulmonary obstruction |
| HP:0007018 | Attention deficit hyperactivity disorder |
| HP:0007086 | Social and occupational deterioration |
| HP:0007302 | Bipolar affective disorder |
| HP:0008872 | Feeding difficulties in infancy |
| HP:0011324 | Multiple suture craniosynostosis |
| HP:0011496 | Corneal neovascularization |
| HP:0011662 | Tricuspid atresia |
| HP:0012303 | Abnormal aortic arch morphology |
| Disease ID | Disease Name |
|---|---|
| OMIM:181500 |
|
| ORPHA:567 |
|
| OMIM:167870 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 109312767 | CROPO18909 | ||
| 113446487 | PSETE19657 | ||
| 100545849 | MELGA04739 | ||
| 103818085 | SERCA12886 | ||
| 100934159 | SARHA07002 | ||
| 103123291 | ERIEU02845 | ||
| 712548 | MACMU00872 | ||
| 101022593 | PAPAN12086 | ||
| 458655 | PANTR25982 | ||
| 445450 | CANLF10595 |
