catechol-O-methyltransferase

Summary
Gene Symbol
  • COMT
Organism
Homo sapiens (human)
External Links
NCBI Gene
1312
KEGG Gene ID
hsa:1312
PubChem
1312
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative initiation
  • Catecholamine metabolism
  • Cell membrane
  • Cytoplasm
  • Direct protein sequencing
  • Lipid metabolism
  • Magnesium
  • Metal-binding
  • Methyltransferase
  • Neurotransmitter degradation
  • Phosphoprotein
  • Reference proteome
  • S-adenosyl-L-methionine
  • Schizophrenia
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying all 2 entries
UniProt Protein Name
P21964
A0A140VJG8
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000093010

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K00545
Name
catechol O-methyltransferase [EC:2.1.1.6]
References
Disease
Disease Ontology
Displaying entries 31 - 40 of 414 in total
DO ID Disease Name Source
DOID:0060402 chromosome 17p13.1 deletion syndrome
DOID:0060668 anencephaly
DOID:0060776 congenital diarrhea 5 with tufting enteropathy
DOID:0060877 bullous congenital ichthyosiform erythroderma
DOID:0060888 transient myeloproliferative syndrome
DOID:0060891 Parkinson's disease 19A
DOID:0060892 late onset Parkinson's disease
DOID:0060895 Parkinson's disease 4
DOID:0060896 Parkinson's disease 23
DOID:0080016 spina bifida
The Human Phenotype Ontology
Displaying entries 41 - 50 of 136 in total
HPO ID HPO Term
HP:0000582 Upslanted palpebral fissure
HP:0000600 Abnormality of the pharynx
HP:0000627 Posterior embryotoxon
HP:0000648 Optic atrophy
HP:0000670 Carious teeth
HP:0000682 Abnormal dental enamel morphology
HP:0000708 Atypical behavior
HP:0000716 Depression
HP:0000717 Autism
HP:0000738 Hallucinations
Displaying all 3 entries
Disease ID Disease Name
OMIM:181500
  • schizophrenia
ORPHA:567
  • 22q11.2 deletion syndrome
OMIM:167870
  • panic disorder 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024