GlyCosmos Portal

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versican

Summary

Gene Symbol

VCAN

Aliases

PG-M
versican proteoglycan

Organism

Homo sapiens (human)

External Links

NCBI Gene

1462

HGNC

2464

KEGG Gene ID

hsa:1462

PubChem

1462

Alliance of Genome Resources

HGNC:2464

Annotation

Keyword

Alternative splicing
Calcium
Cataract
Cell projection
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Hyaluronic acid
Immunoglobulin domain
Lectin
Phosphoprotein
Proteoglycan
Proteomics identification
Reference proteome
Repeat
Signal
Sushi

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q59FG9	Chondroitin sulfate proteoglycan core protein 2 Large fibroblast proteoglycan PG-M
Q6MZK8
P13611	Chondroitin sulfate proteoglycan core protein 2 Glial hyaluronate-binding protein Large fibroblast proteoglycan PG-M
Q86W61

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
skeletal system development	IBA
osteoblast differentiation	HDA	16210410
glial cell differentiation	IBA
cell recognition		2583089
central nervous system development	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

developmental process [inference]

anatomical structure development [inference]

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

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GO Term	Evidence Code	PMID
extracellular matrix		2583089
endoplasmic reticulum lumen
extracellular region	HDA IDA TAS	25122765 27068509
photoreceptor outer segment	IEA
Golgi lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

interphotoreceptor matrix

perisynaptic extracellular matrix [inference]

perineuronal net

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

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GO Term	Evidence Code	PMID
extracellular matrix structural constituent conferring compression resistance	ISS RCA	20551380 25037231 27559042 28327460 28675934
hyaluronic acid binding	IEA
calcium ion binding	IEA
carbohydrate binding	IEA
protein binding	IPI	23601700

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

extracellular matrix structural constituent conferring compression resistance

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

hyaluronic acid binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000038427

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K06793

Name

versican core protein

References

25122765

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0110758	type 1 diabetes mellitus 21	DisGeNET
DOID:0110759	type 1 diabetes mellitus 22	DisGeNET
DOID:0110760	type 1 diabetes mellitus 23	DisGeNET
DOID:0110761	type 1 diabetes mellitus 24	DisGeNET
DOID:0110892	inflammatory bowel disease 1	DisGeNET
DOID:0111343	lateral meningocele syndrome	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET DisGeNET
DOID:10534	stomach cancer	DisGeNET DisGeNET
DOID:10629	microphthalmia	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0007773	Vitreoretinopathy

Displaying 1 entry
Disease ID	Disease Name
OMIM:143200	Wagner disease

PubChem Disease

GHR Health Conditions

Wagner syndrome

MedGen Diseases

Wagner syndrome

OMIM Phenotypes

WAGNER VITREORETINOPATHY; WGVRP

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Orthologous MAtrix
Bos indicus x Bos taurus	113895032	BOBOX24159
Vicugna pacos	102532312	VICPA01308
Otolemur garnettii	100954371	OTOGA15297
Aotus nancymaae	105734690	AOTNA07835
Phascolarctos cinereus	110222771	PHACI05192
Saimiri boliviensis boliviensis	101037526	SAIBB01723
Myotis lucifugus	102440428	MYOLU00199
Rhinolophus ferrumequinum	117024781	RHIFE13262
Taeniopygia guttata	100229875	TAEGU31640
Ficedula albicollis	101808306	FICAL12947

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements