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aldo-keto reductase family 1 member C1

Summary

Gene Symbol

AKR1C1

Aliases

DD1
DDH
HAKRC
MBAB
dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase

Organism

Homo sapiens (human)

External Links

NCBI Gene

1645

HGNC

384

KEGG Gene ID

hsa:1645

PubChem

1645

Alliance of Genome Resources

HGNC:384

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
Lipid metabolism
NADP
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q04828	20-alpha-hydroxysteroid dehydrogenase Chlordecone reductase homolog HAKRC Dihydrodiol dehydrogenase 1 High-affinity hepatic bile acid-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
intestinal cholesterol absorption		8486699
retinal metabolic process	IDA	21851338
cholesterol homeostasis		8486699
retinoid metabolic process
digestion	IDA	8486699

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

secondary metabolic process [inference]

polyketide metabolic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

bile acid metabolic process

cellular aromatic compound metabolic process [inference]

xenobiotic metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

bile acid metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

bile acid metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

polyketide metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

olefinic compound metabolic process [inference]

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

aminoglycoside antibiotic metabolic process [inference]

daunorubicin metabolic process

doxorubicin metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

bile acid metabolic process

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

bile acid metabolic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

bile acid metabolic process

cellular aromatic compound metabolic process [inference]

xenobiotic metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

quinone metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

retinal metabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

digestion

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

response to lipid [inference]

response to fatty acid [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

response to organophosphorus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

response to oxygen-containing compound [inference]

response to fatty acid [inference]

response to jasmonic acid [inference]

cellular response to jasmonic acid stimulus

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to jasmonic acid stimulus

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to jasmonic acid stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

bile acid and bile salt transport

sterol transport [inference]

cholesterol transport [inference]

intestinal cholesterol absorption

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport

sterol transport [inference]

cholesterol transport [inference]

intestinal cholesterol absorption

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of reactive oxygen species metabolic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IBA IDA TAS	8486699
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
androstan-3-alpha,17-beta-diol dehydrogenase activity	IEA
carboxylic acid binding	IDA	8486699
alditol:NADP+ 1-oxidoreductase activity	IBA IDA	21232532
3beta-hydroxy-5beta-steroid dehydrogenase activity	IEA
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	19442656 20837989

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

androsterone dehydrogenase activity

androsterone dehydrogenase (B-specific) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

3beta-hydroxy-5beta-steroid dehydrogenase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

androsterone dehydrogenase activity

androsterone dehydrogenase (B-specific) activity

indanol dehydrogenase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

binding [inference]

protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding

monocarboxylic acid binding [inference]

bile acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding

monocarboxylic acid binding [inference]

bile acid binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000187134

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:24616

17β-estradiol + NADP⁺

H⁺ + estrone + NADPH

Enzyme

1.1.1.62

PMID

RHEA:20381

androsterone + NAD⁺

H⁺ + 5α-androstan-3,17-dione + NADH

Enzyme

1.1.1.209

PMID

RHEA:34783

a 3α-hydroxysteroid + NADP⁺

H⁺ + a 3-oxosteroid + NADPH

Enzyme

PMID

RHEA:24612

17β-estradiol + NAD⁺

H⁺ + estrone + NADH

Enzyme

1.1.1.62

PMID

RHEA:16729

(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP⁺

H⁺ + catechol + NADPH

Enzyme

1.3.1.20

PMID

RHEA:22400

androstan-3α,17β-diol + NAD⁺

H⁺ + NADH + 17β-hydroxyandrostanone

Enzyme

1.1.1.53

PMID

RHEA:15857

(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP⁺

H⁺ + 17α-hydroxyprogesterone + NADPH

Enzyme

1.1.1.149

PMID

RHEA:16297

5α-androstane-3β,17β-diol + NADP⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADPH

Enzyme

1.1.1.210

PMID

RHEA:16321

(S)-indan-1-ol + NADP⁺

H⁺ + indan-1-one + NADPH

Enzyme

1.1.1.112

PMID

RHEA:14981

testosterone + NADP⁺

H⁺ + androst-4-ene-3,17-dione + NADPH

Enzyme

PMID

RHEA:34779

a 3α-hydroxysteroid + NAD⁺

H⁺ + a 3-oxosteroid + NADH

Enzyme

PMID

RHEA:20377

androsterone + NADP⁺

H⁺ + 5α-androstan-3,17-dione + NADPH

Enzyme

1.1.1.209

PMID

RHEA:42004

5α-androstane-3α,17β-diol + NAD⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADH

Enzyme

1.1.1.53

PMID

RHEA:65220

(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP⁺

H⁺ + catechol + NADPH

Enzyme

1.3.1.20

PMID

RHEA:15853

(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD⁺

H⁺ + 17α-hydroxyprogesterone + NADH

Enzyme

1.1.1.149

PMID

RHEA:14929

testosterone + NAD⁺

H⁺ + androst-4-ene-3,17-dione + NADH

Enzyme

PMID

RHEA:16317

(S)-indan-1-ol + NAD⁺

H⁺ + indan-1-one + NADH

Enzyme

1.1.1.112

PMID

4397102

Disease

Disease Ontology

Displaying entries **11 - 20** of 95 in total

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DO ID	Disease Name	Source
DOID:0110056	amelogenesis imperfecta type 1C	DisGeNET
DOID:0110057	amelogenesis imperfecta type 2A1	DisGeNET
DOID:0110058	amelogenesis imperfecta type 1E	DisGeNET
DOID:0110059	X-linked amelogenesis imperfecta hypoplastic/hypomaturation 2	DisGeNET
DOID:0110060	amelogenesis imperfecta hypomaturation type 2A2	DisGeNET
DOID:0110061	amelogenesis imperfecta hypomaturation type 2A3	DisGeNET
DOID:0110062	amelogenesis imperfecta hypomaturation type 2A4	DisGeNET
DOID:0110063	amelogenesis imperfecta hypomaturation type 2A5	DisGeNET
DOID:0110064	amelogenesis imperfecta type 1H	DisGeNET
DOID:0110065	amelogenesis imperfecta type 1F	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002152
Gene Name: aldo-keto reductase family 1, member C1

Ortholog

Displaying entries **1 - 10** of 33 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175047	WB:WBGene00012722
Drosophila melanogaster	39305	FB:FBgn0036183
Danio rerio	326033	ZFIN:ZDB-GENE-030131-4758
Xenopus laevis	447277	Xenbase:XB-GENE-5895956
Xenopus tropicalis	448368	Xenbase:XB-GENE-5757727
Xenopus tropicalis	779650	Xenbase:XB-GENE-5844204
Xenopus tropicalis	100127714	Xenbase:XB-GENE-5895911
Ornithorhynchus anatinus	100085065		ORNAN04476
Macaca fascicularis	101865536		MACFA41893
Macaca fascicularis	102142023		MACFA41893

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Summary

External Links

Annotation

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements