GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase

Summary

Gene Symbol

AGL

Aliases

GDE
glycogen debranching enzyme
glycogen storage disease type III

Organism

Homo sapiens (human)

External Links

NCBI Gene

178

HGNC

321

KEGG Gene ID

hsa:178

PubChem

178

Alliance of Genome Resources

HGNC:321

Annotation

Keyword

Alternative splicing
Cytoplasm
Direct protein sequencing
Disease variant
Glycogen biosynthesis
Glycogen storage disease
Glycosidase
Glycosyltransferase
Multifunctional enzyme
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2A4E4	Glycogen debrancher
P35573	Glycogen debrancher

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycogen catabolic process	IBA TAS
response to glucocorticoid	IEA
response to nutrient	IEA
glycogen biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan catabolic process [inference]

glycogen catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
nucleus	IEA
inclusion body	IEA
cytosol	TAS
extracellular region	TAS
cytoplasm	IDA	17908927

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

isoamylase complex

cellular anatomical entity [inference]

extracellular region

intracellular anatomical structure [inference]

inclusion body

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

endoplasmic reticulum [inference]

sarcoplasmic reticulum

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
4-alpha-glucanotransferase activity	EXP IBA	2961257
beta-maltose 4-alpha-glucanotransferase activity	IEA
glycogen debranching enzyme activity	IEA
protein binding	IPI	17908927 24837458
amylo-alpha-1,6-glucosidase activity	EXP IBA	2961257

GO Hierarchy

molecular function

catalytic activity [inference]

glycogen debranching enzyme activity

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

glucosidase activity [inference]

alpha-glucosidase activity [inference]

amylo-alpha-1,6-glucosidase activity

binding [inference]

protein binding

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding

carbohydrate binding [inference]

polysaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01196

Name

glycogen debranching enzyme [EC:2.4.1.25 3.2.1.33]

References

Disease

Disease Ontology

Displaying entries **81 - 90** of 91 in total

« First

‹ Prev

…

5

6

7

8

9

10

Next ›

Last »
DO ID	Disease Name	Source
DOID:4676	uremia	DisGeNET Alliance of Genome Resources
DOID:5082	liver cirrhosis	DisGeNET
DOID:5672	large intestine cancer	DisGeNET
DOID:612	primary immunodeficiency disease	DisGeNET
DOID:811	lipodystrophy	DisGeNET DisGeNET
DOID:9256	colorectal cancer	DisGeNET DisGeNET
DOID:9266	cystinuria	DisGeNET
DOID:9521	Laron syndrome	DisGeNET
DOID:9870	galactosemia	DisGeNET
DOID:9884	muscular dystrophy	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 24 in total

1

2

3

Next ›

Last »
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000219	Thin upper lip vermilion
HP:0000233	Thin vermilion border
HP:0000272	Malar flattening
HP:0000293	Full cheeks
HP:0000455	Broad nasal tip
HP:0000490	Deeply set eye
HP:0001256	Intellectual disability, mild
HP:0001324	Muscle weakness
HP:0001395	Hepatic fibrosis

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:232400	glycogen storage disease III
ORPHA:366	glycogen storage disease III

PubChem Disease

GHR Health Conditions

Glycogen storage disease type III

MedGen Diseases

Glycogen storage disease type III

OMIM Phenotypes

GLYCOGEN STORAGE DISEASE III; GSD3

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **61 - 70** of **103** in total

« First

‹ Prev

…

3

4

5

6

7

8

9

10

11

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Anolis carolinensis	100565632		ANOCA06015
Ursus maritimus	103669338		URSMA19258
Vombatus ursinus	114047443		VOMUR24126
Bos indicus x Bos taurus	113889569		BOBOX08683
Vicugna pacos	102534130		VICPA00485
Otolemur garnettii	100964110		OTOGA16678
Takifugu rubripes	101071621		TAKRU33237
Chinchilla lanigera	102030231		CHILA09669
Kryptolebias marmoratus	108248238		KRYMA25071
Aotus nancymaae	105721400		AOTNA25061

About Release Notes Help Feedback

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

GlyCosmos Portal v4.0.0

Last updated: August 19, 2024