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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
fibroblast growth factor receptor 2
Summary
- Gene Symbol
-
- FGFR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Apoptosis
- Cell membrane
- Craniosynostosis
- Cytoplasmic vesicle
- Disease variant
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Heparin-binding
- Immunoglobulin domain
- Intellectual disability
- Lacrimo-auriculo-dento-digital syndrome
- Phosphoprotein
- Proteomics identification
- Proto-oncogene
- Receptor
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P21802 |
|
| D2CGD1 |
|
| S4R381 |
|
| A0A141AXF1 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of ERK1 and ERK2 cascade | ||
| ureteric bud development | ||
| mesenchymal cell differentiation | ||
| mesenchymal cell differentiation involved in lung development | ||
| cellular response to retinoic acid |
GO Hierarchy
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
biological process
metabolic process [inference]
cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway
fibroblast growth factor receptor signaling pathway
reproductive process [inference]
developmental process [inference]
developmental process involved in reproduction [inference]
anatomical structure morphogenesis [inference]
anatomical structure development [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of growth [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway
fibroblast growth factor receptor signaling pathway
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasmic vesicle | ||
| membrane | ||
| Golgi apparatus | ||
| cell cortex | ||
| receptor complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| fibroblast growth factor binding | ||
| heparin binding | ||
| identical protein binding | ||
| protein tyrosine kinase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Fibroblast growth factor receptor
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| fibroblast growth factor receptor activity |
| nucleotide binding |
| transmembrane receptor protein tyrosine kinase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10534 | stomach cancer | |
| DOID:10584 | retinitis pigmentosa | |
| DOID:10762 | portal hypertension | |
| DOID:10825 | essential hypertension | |
| DOID:10892 | hypospadias | |
| DOID:11054 | urinary bladder cancer | |
| DOID:12960 | acrocephalosyndactylia | |
| DOID:14557 | primary pulmonary hypertension | |
| DOID:14705 | Pfeiffer syndrome | |
| DOID:14768 | Saethre-Chotzen syndrome |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 102170938 | CAPHI17593 | |||
| 102443772 | PELSI14218 | |||
| 103024961 | ASTMX12948 | |||
| 103185425 | CALMI32182 | |||
| 103216628 | CHLSB18168 | |||
| 103250719 | CARSF16054 | |||
| 103729272 | NANGA04739 | |||
| 103813785 | SERCA07397 | |||
| 104675847 | RHIRO35532 | |||
| 105291441 | PTEVA11115 |
