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fibroblast growth factor receptor 2
Summary
- Gene Symbol
-
- FGFR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Apoptosis
- Cell membrane
- Craniosynostosis
- Cytoplasmic vesicle
- Disease variant
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Heparin-binding
- Immunoglobulin domain
- Intellectual disability
- Lacrimo-auriculo-dento-digital syndrome
- Phosphoprotein
- Proteomics identification
- Proto-oncogene
- Receptor
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P21802 |
|
| D2CGD1 |
|
| S4R381 |
|
| A0A141AXF1 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| bone development | ||
| negative regulation of keratinocyte proliferation | ||
| regulation of osteoblast differentiation | ||
| positive regulation of canonical Wnt signaling pathway | ||
| positive regulation of transcription by RNA polymerase II |
GO Hierarchy
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification
biological process
metabolic process [inference]
cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway
fibroblast growth factor receptor signaling pathway
reproductive process [inference]
developmental process [inference]
developmental process involved in reproduction [inference]
anatomical structure morphogenesis [inference]
anatomical structure development [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of growth [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
cell surface receptor signaling pathway [inference]
enzyme-linked receptor protein signaling pathway [inference]
transmembrane receptor protein tyrosine kinase signaling pathway
fibroblast growth factor receptor signaling pathway
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasmic vesicle | ||
| membrane | ||
| Golgi apparatus | ||
| cell cortex | ||
| receptor complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| fibroblast growth factor binding | ||
| heparin binding | ||
| identical protein binding | ||
| protein tyrosine kinase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Fibroblast growth factor receptor
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| fibroblast growth factor receptor activity |
| nucleotide binding |
| transmembrane receptor protein tyrosine kinase activity |
| InterPro |
|---|
| Tyrosine-protein kinase, active site |
| Tyrosine-protein kinase, catalytic domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0050331 | lacrimoauriculodentodigital syndrome 1 | |
| DOID:0050660 | Beare-Stevenson cutis gyrata syndrome | |
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:0080001 | bone disease | |
| DOID:0081289 | Antley-Bixler syndrome | |
| DOID:0081290 | Antley-Bixler syndrome without disordered steroidogenesis | |
| DOID:0111337 | Jackson-Weiss syndrome | |
| DOID:10283 | prostate cancer | |
| DOID:10486 | intestinal atresia |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 101073665 | TAKRU39460 | |||
| 101095198 | FELCA26944 | |||
| 101153046 | 9595_0:002ead | GORGO01094 | ||
| 101319881 | TURTR11252 | |||
| 101593125 | OCTDE03052 | |||
| 101594955 | JACJA10891 | |||
| 101683248 | MUSPF13860 | |||
| 101812169 | FICAL06823 | |||
| 101933273 | CHRPI20782 | |||
| 102143086 | MACFA43536 |
