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Guidelines

MIRAGE

interleukin 13 receptor subunit alpha 2

Summary

Gene Symbol

IL13RA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3598

PubChem

3598

Alliance of Genome Resources

HGNC:5975

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14627	Interleukin-13-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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2
GO Term	Evidence Code	PMID
negative regulation of mast cell degranulation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-13-mediated signaling pathway

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-13-mediated signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	TAS	9083087
plasma membrane	IDA	18694590
external side of plasma membrane	IBA
receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytokine receptor activity	TAS	9725226
cytokine receptor activity	IDA	16327802
cytokine receptor activity	IBA
protein binding	IPI	20223216 23972995 27629921 28143526 29427412 32296183
cytokine binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-13 receptor subunit alpha-2

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
erythropoietin receptor activity

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Type I cytokine receptor, cytokine-binding domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3598	Xenbase:XB-GENE-492772
Mus musculus	16165	Xenbase:XB-GENE-492772	MOUSE64567
Rattus norvegicus	171060		RATNO45217
Canis lupus familiaris	403622		CANLF20075
Bos taurus	616008		BOVIN36776
Macaca mulatta	708339		MACMU47201
Monodelphis domestica	100010896		MONDO36326
Equus caballus	100057673		HORSE44589
Sus scrofa	100156991		PIGXX37883
Taeniopygia guttata	100229083		TAEGU22843

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Last updated: August 4, 2025