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leukotriene A4 hydrolase

Summary

Gene Symbol

LTA4H

Organism

Homo sapiens (human)

External Links

NCBI Gene

4048

HGNC

6710

KEGG Gene ID

hsa:4048

PubChem

4048

Alliance of Genome Resources

HGNC:6710

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Leukotriene biosynthesis
Lipid metabolism
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P09960	Leukotriene A(4) hydrolase Tripeptide aminopeptidase LTA4H
A0A140VK27

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
leukotriene biosynthetic process	IBA IDA IMP	11675384 15078870 9774412
peptide catabolic process	IBA IDA	15078870 18804029 9774412
lipid metabolic process	IEA
proteolysis	IEA
response to zinc ion	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process

proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

cellular catabolic process [inference]

peptide catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

primary metabolic process [inference]

lipid metabolic process

protein metabolic process

proteolysis

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process

proteolysis

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process

proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process [inference]

leukotriene biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

cellular catabolic process [inference]

peptide catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

lung epithelial cell differentiation [inference]

type I pneumocyte differentiation

lung cell differentiation [inference]

lung epithelial cell differentiation [inference]

type I pneumocyte differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

lung epithelial cell differentiation [inference]

type I pneumocyte differentiation

lung cell differentiation [inference]

lung epithelial cell differentiation [inference]

type I pneumocyte differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone

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GO Term	Evidence Code	PMID
nucleus	IBA
cytosol	IBA IDA TAS
extracellular region
tertiary granule lumen
ficolin-1-rich granule lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
zinc ion binding	IDA IMP	11675384 15078870 18804029
metalloaminopeptidase activity	IMP	11675384
peptidase activity		1881903
aminopeptidase activity	IBA IDA	15078870 18804029 9774412
tripeptide aminopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

tripeptidase activity [inference]

tripeptide aminopeptidase activity

hydrolase activity, acting on ether bonds [inference]

ether hydrolase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

tripeptidase activity [inference]

tripeptide aminopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000111144

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01254

Name

leukotriene-A4 hydrolase [EC:3.3.2.6]

References

Rhea

RHEA:22324

H₂O + leukotriene A₄

leukotriene B₄

Enzyme

3.3.2.6

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:1470	major depressive disorder	DisGeNET DisGeNET
DOID:1595	melancholic depression	DisGeNET
DOID:1596	depressive disorder	DisGeNET DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:1749	squamous cell carcinoma	DisGeNET DisGeNET Alliance of Genome Resources
DOID:1793	pancreatic cancer	DisGeNET DisGeNET
DOID:1909	melanoma	DisGeNET
DOID:1936	atherosclerosis	DisGeNET DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET
DOID:2349	arteriosclerosis	DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001056
Gene Name: leukotriene A4 hydrolase

Ortholog

Displaying entries **21 - 30** of 87 in total

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Species	Gene ID	Orthologous MAtrix
Crocodylus porosus	109316769	CROPO05958
Pseudonaja textilis	113434895	PSETE00477
Serinus canaria	103813389	SERCA05996
Sarcophilus harrisii	100930803	SARHA12282
Callithrix jacchus	100413464	CALJA45261
Cercocebus atys	105573420	CERAT12405
Macaca fascicularis	102117003	MACFA04105
Macaca mulatta	713038	MACMU04673
Macaca nemestrina	105483662	MACNE23781
Papio anubis	101011580	PAPAN41736