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malic enzyme 2

Summary

Gene Symbol

ME2

Aliases

NAD-dependent malic enzyme, mitochondrial
malate dehydrogenase (oxaloacetate-decarboxylating)

Organism

Homo sapiens (human)

External Links

NCBI Gene

4200

HGNC

6984

KEGG Gene ID

hsa:4200

PubChem

4200

Alliance of Genome Resources

HGNC:6984

Annotation

Keyword

3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Direct protein sequencing
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P23368	Malic enzyme 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
regulation of NADP metabolic process	IMP	23334421
malate metabolic process	IBA
pyruvate metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
mitochondrial matrix
mitochondrion	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
electron transfer activity		1993674
oxaloacetate decarboxylase activity	IEA
malate dehydrogenase (decarboxylating) (NADP+) activity	IBA
malic enzyme activity	IMP	23334421
NAD binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity [inference]

malic enzyme activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

oxaloacetate decarboxylase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000082212

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00027

Name

malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]

References

225306

Rhea

H⁺ + oxaloacetate

pyruvate + CO₂

Enzyme

PMID

(S)-malate + NAD⁺

pyruvate + CO₂ + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **11 - 20** of 21 in total

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DO ID	Disease Name	Source
DOID:2468	psychotic disorder	DisGeNET
DOID:3068	glioblastoma	DisGeNET
DOID:3070	high grade glioma	DisGeNET
DOID:3074	giant cell glioblastoma	DisGeNET
DOID:3312	bipolar disorder	DisGeNET DisGeNET DisGeNET
DOID:3683	lung benign neoplasm	DisGeNET
DOID:3908	lung non-small cell carcinoma	DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:4905	pancreatic carcinoma	DisGeNET
DOID:5418	schizoaffective disorder	DisGeNET

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175079	WB:WBGene00012983
Drosophila melanogaster	43936	FB:FBgn0029155
Drosophila melanogaster	47173	FB:FBgn0002719
Callorhinchus milii	103187336		CALMI36579
Danio rerio	445233	ZFIN:ZDB-GENE-040801-147	DANRE35667
Ictalurus punctatus	108255419		ICTPU17808
Salmo trutta	115164983		SALTR59908
Gadus morhua	115546090		GADMO51771
Oryzias latipes	101168546		ORYLA17472
Oreochromis niloticus	100698053		ORENI10181

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Last updated: August 19, 2024