GlyCosmos Portal

Annotation

Keyword

3D-structure
Carbohydrate metabolism
Cytoplasm
Glycosidase
Lipid degradation
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y3R4	Cytosolic sialidase N-acetyl-alpha-neuraminidase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycosphingolipid catabolic process	TAS
oligosaccharide catabolic process	IBA IDA	14613940 22228546 26193330
ganglioside catabolic process	IBA IDA	14613940 22228546
glycoprotein catabolic process	IDA	14613940

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

carbohydrate catabolic process [inference]

oligosaccharide catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	IDA TAS	10561456 26193330
cytoplasm	IBA
catalytic complex	IDA	26193330
membrane	IBA
lysosome	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
exo-alpha-(2->6)-sialidase activity	IEA
exo-alpha-(2->3)-sialidase activity	IDA	14613940 22228546
exo-alpha-sialidase activity	IBA IDA TAS	26193330
exo-alpha-(2->8)-sialidase activity	IDA	14613940
protein binding	IPI	25416956 25910212 26193330 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

alpha-sialidase activity [inference]

exo-alpha-sialidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K12357

Name

sialidase-2/3/4 [EC:3.2.1.18]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06147	3.2.1.18	G65889KE	G30207PZ

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:10534	stomach cancer	DisGeNET DisGeNET
DOID:162	cancer	DisGeNET
DOID:1793	pancreatic cancer	DisGeNET
DOID:3247	rhabdomyosarcoma	DisGeNET
DOID:3498	pancreatic ductal adenocarcinoma	DisGeNET
DOID:4481	allergic rhinitis	DisGeNET
DOID:4730	vasomotor rhinitis	DisGeNET
DOID:4905	pancreatic carcinoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000194
Gene Name: sialidase 2 (cytosolic sialidase)

Ortholog

Displaying entries **11 - 20** of 61 in total

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Species	Gene ID	Orthologous MAtrix
Macaca mulatta	713979	MACMU05598
Macaca nemestrina	105473899	MACNE18775
Papio anubis	101004956	PAPAN01727
Mandrillus leucophaeus	105539806	MANLE03238
Gorilla gorilla gorilla	101139512	GORGO26163
Pan paniscus	100988881	PANPA26920
Pan troglodytes	470682	PANTR30063
Pongo abelii	100444319	PONAB24941
Canis lupus familiaris	486166	CANLF10102
Vulpes vulpes	112925490	VULVU19576

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements