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solute carrier family 35 member C1

Summary

Gene Symbol

SLC35C1

Aliases

FLJ11320
FUCT1
GDP-fucose transporter 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

55343

GGDB ID

gg173

HGNC

20197

mRNA

NM_018389

map

11p11.2

Protein

NP_060859

OMIM

605881

KEGG Gene ID

hsa:55343

PubChem

55343

Alliance of Genome Resources

HGNC:20197

Annotation

Keyword

Alternative splicing
Congenital disorder of glycosylation
Disease variant
Golgi apparatus
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q96A29	Solute carrier family 35 member C1
B3KQH0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GDP-fucose import into Golgi lumen	IBA IDA	11326280
lipid glycosylation	IEA
negative regulation of Notch signaling pathway	IEA
protein O-linked fucosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

glycosylation [inference]

lipid glycosylation

fucosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

transmembrane transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

cytosol to Golgi apparatus transport [inference]

GDP-fucose import into Golgi lumen

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

cytosol to Golgi apparatus transport [inference]

GDP-fucose import into Golgi lumen

organic substance transport [inference]

nucleobase-containing compound transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

carbohydrate derivative transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide-sugar transmembrane transport [inference]

purine nucleotide-sugar transmembrane transport [inference]

GDP-fucose transmembrane transport [inference]

GDP-fucose import into Golgi lumen

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IBA IDA
Golgi membrane	IDA TAS	11326279

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
GDP-fucose transmembrane transporter activity	IBA IDA TAS	27738779
antiporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

purine nucleotide-sugar transmembrane transporter activity [inference]

GDP-fucose transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

purine nucleotide-sugar transmembrane transporter activity [inference]

GDP-fucose transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000181830

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg173

Gene Symbol

SLC35C1

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	XP_230292	XM_230292
Drosophila melanogaster	NP_649782	NM_141525
Caenorhabditis elegans	NP_505467	NM_073066
Mus musculus	NP_997597	NM_211358

KEGG BRITE Database

Orthology

K15279

Name

solute carrier family 35 (GDP-fucose transporter), member C1

References

12759756

Disease

Disease Ontology

Displaying entries **1 - 10** of 13 in total

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DO ID	Disease Name	Source
DOID:0050571	congenital disorder of glycosylation type II	DisGeNET Alliance of Genome Resources
DOID:0070255	congenital disorder of glycosylation type IIc	Glyco-Disease Genes Database DisGeNET Alliance of Genome Resources
DOID:0080492	leukocyte adhesion deficiency 2	DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:14320	generalized anxiety disorder	DisGeNET
DOID:2030	anxiety disorder	DisGeNET
DOID:3488	cellulitis	DisGeNET
DOID:3571	liver cancer	DisGeNET
DOID:4188	echolalia	DisGeNET
DOID:4480	achondroplasia	DisGeNET

The Human Phenotype Ontology

Displaying entries **51 - 60** of 75 in total

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HPO ID	HPO Term
HP:0002360	Sleep abnormality
HP:0002373	Febrile seizure (within the age range of 3 months to 6 years)
HP:0002719	Recurrent infections
HP:0004322	Short stature
HP:0005280	Depressed nasal bridge
HP:0005400	Reduction of neutrophil motility
HP:0006480	Premature loss of teeth
HP:0006532	Recurrent pneumonia
HP:0006887	Intellectual disability, progressive
HP:0006895	Lower limb hypertonia

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:266265	leukocyte adhesion deficiency type II
ORPHA:99843	leukocyte adhesion deficiency type II

PubChem Disease

MedGen Diseases

Leukocyte adhesion deficiency type II

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIc; CDG2C

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **51 - 60** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Oryctolagus cuniculus	100348541		RABIT01197
Dipodomys ordii	105996004		DIPOR17302
Cricetulus griseus	100689382		CRIGR03171
Mus musculus	228368	MGI:2443301	MOUSE33464
Rattus norvegicus	311204	RGD:1309463	RATNO29095
Cavia porcellus	100724079		CAVPO19722
Octodon degus	101571943		OCTDE04726
Heterocephalus glaber	101707959		HETGA04141
Monodelphis domestica	100011308		MONDO27419
Pelodiscus sinensis	102450494		PELSI16886

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements