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transmembrane protein 165

Summary

Gene Symbol

TMEM165

Aliases

GDT1
SLC64A1
TMPT27
TPA regulated locus
TPARL

Organism

Homo sapiens (human)

External Links

NCBI Gene

55858

HGNC

30760

KEGG Gene ID

hsa:55858

PubChem

55858

Alliance of Genome Resources

HGNC:30760

Annotation

Keyword

Alternative splicing
Antiport
Coiled coil
Congenital disorder of glycosylation
Disease variant
Golgi apparatus
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9HC07	Transmembrane protein 165 Transmembrane protein PT27 Transmembrane protein TPARL

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
calcium ion transport	IDA	32047108
protein N-linked glycosylation	IMP	22683087
intracellular calcium ion homeostasis	IGI	23569283
Golgi calcium ion homeostasis	IBA
calcium ion transmembrane transport	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

Golgi calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

Golgi calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

Golgi calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

Golgi calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

Golgi calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

Golgi calcium ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

manganese ion transport

manganese ion transmembrane transport

calcium ion transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

organic substance transport [inference]

calcium ion transport

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH

regulation of biological quality [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH

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GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
cis-Golgi network membrane	ISS
trans-Golgi network membrane	IDA	23575229
lysosomal membrane	IDA	23575229
Golgi apparatus	IBA IDA	22683087

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

trans-Golgi network membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
antiporter activity	IEA
calcium ion transmembrane transporter activity	IBA
manganese ion transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

transition metal ion transmembrane transporter activity [inference]

manganese ion transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

transition metal ion transmembrane transporter activity [inference]

manganese ion transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000134851

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K23541

Name

Ca2+/H+ antiporter, TMEM165/GDT1 family

References

23569283

Disease

Disease Ontology

Displaying entries **1 - 10** of 44 in total

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DO ID	Disease Name	Source
DOID:0050571	congenital disorder of glycosylation type II	DisGeNET Alliance of Genome Resources
DOID:0060249	scoliosis	DisGeNET
DOID:0070263	congenital disorder of glycosylation type IIk	Glyco-Disease Genes Database DisGeNET Alliance of Genome Resources
DOID:0110052	amelogenesis imperfecta type 1B	DisGeNET
DOID:0110053	amelogenesis imperfecta type 4	DisGeNET
DOID:0110054	amelogenesis imperfecta type 1A	DisGeNET
DOID:0110055	amelogenesis imperfecta type 3A	DisGeNET
DOID:0110056	amelogenesis imperfecta type 1C	DisGeNET
DOID:0110057	amelogenesis imperfecta type 2A1	DisGeNET
DOID:0110058	amelogenesis imperfecta type 1E	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0001382	Joint hypermobility
HP:0001508	Failure to thrive
HP:0001510	Growth delay
HP:0001873	Thrombocytopenia
HP:0001955	Unexplained fevers
HP:0002240	Hepatomegaly
HP:0002500	Abnormal cerebral white matter morphology
HP:0002656	Epiphyseal dysplasia
HP:0002751	Kyphoscoliosis
HP:0003236	Elevated circulating creatine kinase concentration

Displaying 1 entry
Disease ID	Disease Name
OMIM:614727	TMEM165-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

TMEM165-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIk; CDG2K

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175368	WB:WBGene00021847
Drosophila melanogaster	8674000	FB:FBgn0260659
Callorhinchus milii	103178170		CALMI14895
Latimeria chalumnae	102363414		LATCH09740
Danio rerio	324501	ZFIN:ZDB-GENE-030131-3222	DANRE19459
Astyanax mexicanus	103045178		ASTMX11112
Ictalurus punctatus	108257919		ICTPU20162
Electrophorus electricus	113586388		ELEEL36914
Salmo salar	106560271		SALSA10501
Salmo salar	106584122		SALSA85193

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements