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glucose-6-phosphatase catalytic subunit 2

Summary

Gene Symbol

G6PC2

Aliases

IGRP
islet specific glucose 6 phosphatase catalytic subunit related protein

Organism

Homo sapiens (human)

External Links

NCBI Gene

57818

HGNC

28906

KEGG Gene ID

hsa:57818

PubChem

57818

Alliance of Genome Resources

HGNC:28906

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Gluconeogenesis
Glycoprotein
Hydrolase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NQR9	Islet-specific glucose-6-phosphatase catalytic subunit-related protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of insulin secretion	IMP	20668700
glucose 6-phosphate metabolic process	IBA
glucose homeostasis	IMP	20668700
gluconeogenesis	IBA IEA TAS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

carbohydrate derivative metabolic process [inference]

glucose 6-phosphate metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
glucose-6-phosphatase activity	EXP IBA	14722102

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

sugar-terminal-phosphatase activity [inference]

glucose-6-phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01084

Name

glucose-6-phosphatase [EC:3.1.3.9]

References

19700406

Rhea

H₂O + D-glucose 6-phosphate

D-glucose + phosphate

Enzyme

PMID

H₂O + α-D-glucose 6-phosphate

α-D-glucose + phosphate

Enzyme

Disease

Disease Ontology

Displaying entries **21 - 30** of 44 in total

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DO ID	Disease Name	Source
DOID:0110760	type 1 diabetes mellitus 23	DisGeNET
DOID:0110761	type 1 diabetes mellitus 24	DisGeNET
DOID:0111040	glycogen storage disease IXd	DisGeNET
DOID:0111041	glycogen storage disease IXb	DisGeNET
DOID:0111042	glycogen storage disease IXa	DisGeNET
DOID:0111043	glycogen storage disease IXc	DisGeNET
DOID:10603	glucose intolerance	DisGeNET
DOID:11714	gestational diabetes	DisGeNET
DOID:11716	prediabetes syndrome	DisGeNET
DOID:14221	abdominal obesity-metabolic syndrome 1	DisGeNET

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33476	FB:FBgn0031463
Petromyzon marinus	116954788		PETMA09628
Callorhinchus milii	103176385		CALMI10119
Latimeria chalumnae	102352326		LATCH09790
Salmo salar	106586204		SALSA92368
Salmo trutta	115161504		SALTR16520
Poecilia reticulata	103461716		POERE22915
Xiphophorus maculatus	102218625		XIPMA33294
Oryzias latipes	101156928		ORYLA09842
Oreochromis niloticus	100699749		ORENI23078

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Last updated: August 19, 2024