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neurexin 1

Summary

Gene Symbol

Nrxn1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

60391

PubChem

60391

Alliance of Genome Resources

RGD:628659

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cell projection
Direct protein sequencing
Disulfide bond
EGF-like domain
Heparan sulfate
Metal-binding
Reference proteome
Repeat
Signal
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q63372	Neurexin I-alpha Neurexin-1-alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of **132** in total

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GO Term	Evidence Code	PMID
angiogenesis	ISS
vesicle docking involved in exocytosis	IMP	22235116
cell adhesion	IEA
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

trans-synaptic signaling, modulating synaptic transmission

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

signal transduction

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar granule cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar granule cell differentiation

glutamatergic neuron differentiation [inference]

cerebellar granule cell differentiation

cell maturation [inference]

neuron maturation

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to cell junction [inference]

protein localization to synapse

gephyrin clustering involved in postsynaptic density assembly

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell junction assembly [inference]

synapse assembly

protein-containing complex assembly [inference]

protein-containing complex assembly involved in synapse maturation

membrane assembly [inference]

presynapse assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

cell junction maintenance [inference]

maintenance of synapse structure

synapse organization [inference]

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-containing complex assembly involved in synapse maturation

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure

membrane organization [inference]

postsynaptic membrane organization [inference]

postsynaptic membrane assembly

membrane assembly [inference]

presynaptic membrane organization [inference]

presynaptic membrane assembly

presynapse organization [inference]

presynapse assembly

exocytic process [inference]

vesicle docking involved in exocytosis

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

learning or memory [inference]

learning

observational learning [inference]

imitative learning [inference]

vocal learning

learned vocalization behavior or vocal learning [inference]

vocal learning

mechanosensory behavior [inference]

auditory behavior [inference]

vocal learning

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

developmental maturation [inference]

synapse maturation

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation in hindbrain [inference]

cerebellar granule cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar granule cell differentiation

glutamatergic neuron differentiation [inference]

cerebellar granule cell differentiation

cell maturation [inference]

neuron maturation

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

localization [inference]

protein-containing complex localization [inference]

receptor localization to synapse

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to cell junction [inference]

protein localization to synapse

gephyrin clustering involved in postsynaptic density assembly

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of protein localization

establishment of localization in cell [inference]

neurotransmitter secretion

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

neuroligin clustering involved in postsynaptic membrane assembly

protein localization to cell junction [inference]

protein localization to synapse

gephyrin clustering involved in postsynaptic density assembly

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of neuromuscular synaptic transmission [inference]

positive regulation of neuromuscular synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

trans-synaptic signaling, modulating synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of synaptic vesicle cycle

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of synapse maturation

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of synapse maturation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

prepulse inhibition

regulation of cellular response to growth factor stimulus [inference]

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of synapse maturation

regulation of synapse maturation [inference]

positive regulation of synapse maturation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

regulation of fibroblast growth factor receptor signaling pathway [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cAMP-mediated signaling [inference]

positive regulation of cAMP-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

positive regulation of synaptic transmission, GABAergic

positive regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

positive regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of neuromuscular synaptic transmission [inference]

positive regulation of neuromuscular synaptic transmission

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of presynapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly

regulation of postsynaptic density assembly

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of excitatory postsynaptic potential

positive regulation of synaptic transmission [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of synapse maturation

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of postsynaptic specialization assembly

regulation of postsynaptic density assembly

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density assembly

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of presynapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

regulation of synapse maturation [inference]

positive regulation of synapse maturation

regulation of presynapse organization [inference]

regulation of presynapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

regulation of postsynapse organization [inference]

regulation of postsynaptic density organization [inference]

regulation of postsynaptic density assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of synapse maturation

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

regulation of excitatory synapse assembly [inference]

regulation of postsynaptic density assembly

regulation of presynapse assembly

positive regulation of presynapse assembly [inference]

positive regulation of presynaptic active zone assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of presynaptic active zone assembly [inference]

positive regulation of presynaptic active zone assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of vesicle-mediated transport [inference]

regulation of synaptic vesicle cycle

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

regulation of behavior [inference]

regulation of grooming behavior

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of biological quality [inference]

regulation of membrane potential [inference]

modulation of excitatory postsynaptic potential [inference]

positive regulation of excitatory postsynaptic potential

Displaying entries **1 - 5** of 49 in total

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GO Term	Evidence Code	PMID
nucleolus	ISO
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO
endoplasmic reticulum	IEA
plasma membrane	ISO

GO Hierarchy

cellular component

protein-containing complex

protein complex involved in cell adhesion [inference]

protein complex involved in cell-cell adhesion

trans-synaptic protein complex

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

nuclear membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

anchoring junction [inference]

cell-cell junction [inference]

filtration diaphragm [inference]

slit diaphragm

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

cell projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular non-membrane-bounded organelle [inference]

nucleolus

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	ISO
transmembrane signaling receptor activity	IDA	15797875
signaling receptor binding	IPI	15797875
type 1 fibroblast growth factor receptor binding	ISO
calcium channel regulator activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

acetylcholine receptor binding

growth factor receptor binding [inference]

fibroblast growth factor receptor binding [inference]

type 1 fibroblast growth factor receptor binding

neuroligin family protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

neurexin-1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like domain
Laminin G domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
slit diaphragm	PMID:21048075

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 46** of 46 in total

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Species	Gene ID	Orthologous MAtrix
Sparus aurata	115597081	SPAAU11403
Rhinopithecus roxellana	115894351	RHIRO10284
Rhinolophus ferrumequinum	117032878	RHIFE24885
Scophthalmus maximus	118283604	SCOMX08258
Balaenoptera musculus	118906086	BALMU05185
Panthera leo	122216043	PANLE01813

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements