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succinate dehydrogenase complex iron sulfur subunit B
Summary
- Gene Symbol
-
- SDHB
- Aliases
-
- iron-sulfur subunit of complex II
- succinate dehydrogenase [ubiquinone] iron-sulfur subunit
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 2Fe-2S
- 3D-structure
- 3Fe-4S
- 4Fe-4S
- Acetylation
- Disease variant
- Electron transport
- Host-virus interaction
- Mitochondrion inner membrane
- Oxidoreductase
- Primary mitochondrial disease
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Proteins
| UniProt | Protein Name |
|---|---|
| P21912 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proton motive force-driven mitochondrial ATP synthesis |
|
|
| aerobic respiration | ||
| mitochondrial electron transport, succinate to ubiquinone |
|
|
| respiratory electron transport chain | ||
| tricarboxylic acid cycle |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| electron transfer activity | ||
| ubiquinone binding | ||
| 2 iron, 2 sulfur cluster binding | ||
| succinate dehydrogenase (ubiquinone) activity | ||
| 4 iron, 4 sulfur cluster binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050811 | congenital adrenal hyperplasia | |
| DOID:0060249 | scoliosis | |
| DOID:0060537 | mitochondrial complex II deficiency | |
| DOID:0070042 | Coffin-Siris syndrome 1 | |
| DOID:0070285 | primary autosomal recessive microcephaly 1 | |
| DOID:0080092 | myofibrillar myopathy 1 | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080324 | tuberous sclerosis 1 | |
| DOID:0080326 | familial hypertrophic cardiomyopathy | |
| DOID:0080347 | malignant pheochromocytoma |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001626 | Abnormality of the cardiovascular system |
| HP:0001635 | Congestive heart failure |
| HP:0001639 | Hypertrophic cardiomyopathy |
| HP:0001649 | Tachycardia |
| HP:0001712 | Left ventricular hypertrophy |
| HP:0001824 | Weight loss |
| HP:0001903 | Anemia |
| HP:0001962 | Palpitations |
| HP:0002015 | Dysphagia |
| HP:0002017 | Nausea and vomiting |
| Disease ID | Disease Name |
|---|---|
| ORPHA:276621 |
|
| OMIM:115310 |
|
| OMIM:606864 |
|
| ORPHA:201 |
|
| ORPHA:3208 |
|
| ORPHA:97286 |
|
| OMIM:606764 |
|
| ORPHA:44890 |
|
| ORPHA:29072 |
|
| OMIM:619224 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000586
- Gene Name
- succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 174482 | WB:WBGene00006433 | ||
| 32887 | FB:FBgn0030975 | ||
| 35590 | FB:FBgn0014028 | ||
| 100181830 | CIOIN08963 | ||
| 103187447 | CALMI36772 | ||
| 102358325 | LATCH13447 | ||
| 135352526 | LATCH13447 | ||
| 562149 | ZFIN:ZDB-GENE-030131-8005 | DANRE23737 | |
| 100528601 | ICTPU15933 | ||
| 113582781 | ELEEL30391 |
