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surfactant protein C

Summary

Gene Symbol

SFTPC

Aliases

BRICD6
BRICHOS domain containing 6
PSP-C
SMDP2
SP-C

Organism

Homo sapiens (human)

External Links

NCBI Gene

6440

HGNC

10802

KEGG Gene ID

hsa:6440

PubChem

6440

Alliance of Genome Resources

HGNC:10802

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Disulfide bond
Palmitate
Proteomics identification
Reference proteome
Surface film
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P11686	Pulmonary surfactant-associated protein C Pulmonary surfactant-associated proteolipid SPL(Val) SP5
A0A0S2Z4Q0	Pulmonary surfactant-associated protein C Pulmonary surfactant-associated proteolipid SPL(Val)
E5RI64	Pulmonary surfactant-associated protein C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
respiratory gaseous exchange by respiratory system	IEA

GO Hierarchy

biological process

multicellular organismal process [inference]

respiratory gaseous exchange by respiratory system

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GO Term	Evidence Code	PMID
alveolar lamellar body	IBA
multivesicular body lumen
lamellar body
extracellular region
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen [inference]

late endosome lumen [inference]

multivesicular body lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19815549 25416956 25910212 26871637 31515488 32296183
identical protein binding	IPI	25416956 25910212 31515488 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000168484

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K26068

Name

pulmonary surfactant-associated protein C

References

3035561

Disease

Disease Ontology

Displaying entries **41 - 50** of 93 in total

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DO ID	Disease Name	Source
DOID:13976	peptic esophagitis	DisGeNET
DOID:14159	obstructive hydrocephalus	DisGeNET
DOID:14265	pulmonary valve insufficiency	DisGeNET
DOID:1443	cerebral degeneration	DisGeNET
DOID:14498	lipoid proteinosis	DisGeNET
DOID:14524	senile degeneration of brain	DisGeNET
DOID:14525	Reye syndrome	DisGeNET
DOID:14557	primary pulmonary hypertension	DisGeNET
DOID:1485	cystic fibrosis	DisGeNET Alliance of Genome Resources
DOID:1573	communicating hydrocephalus	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000765	Abnormal thorax morphology
HP:0000961	Cyanosis
HP:0001063	Acrocyanosis
HP:0001217	Clubbing
HP:0001263	Global developmental delay
HP:0001394	Cirrhosis
HP:0001508	Failure to thrive
HP:0001622	Premature birth
HP:0001649	Tachycardia

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:610913	surfactant metabolism dysfunction, pulmonary, 2
ORPHA:70587	respiratory distress syndrome in premature infants
OMIM:178500	interstitial lung disease 2
ORPHA:2032	interstitial lung disease 2

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2; SMDP2

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	779071	Xenbase:XB-GENE-6489007
Xenopus laevis	108711616	Xenbase:XB-GENE-17346349
Xenopus tropicalis	100038236	Xenbase:XB-GENE-852771
Ornithorhynchus anatinus	100087361		ORNAN22113
Sarcophilus harrisii	100932570		SARHA12224
Callithrix jacchus	100399602		CALJA09734
Cercocebus atys	105579236		CERAT15411
Macaca mulatta	707696		MACMU43312
Macaca nemestrina	105482086		MACNE24625
Papio anubis	101023763		PAPAN38681

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements