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surfactant protein C

Summary

Gene Symbol

SFTPC

Aliases

BRICD6
BRICHOS domain containing 6
PSP-C
SMDP2
SP-C

Organism

Homo sapiens (human)

External Links

NCBI Gene

6440

HGNC

10802

KEGG Gene ID

hsa:6440

PubChem

6440

Alliance of Genome Resources

HGNC:10802

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Disulfide bond
Palmitate
Proteomics identification
Reference proteome
Surface film
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P11686	Pulmonary surfactant-associated protein C Pulmonary surfactant-associated proteolipid SPL(Val) SP5
A0A0S2Z4Q0	Pulmonary surfactant-associated protein C Pulmonary surfactant-associated proteolipid SPL(Val)
E5RI64	Pulmonary surfactant-associated protein C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
respiratory gaseous exchange by respiratory system	IEA

GO Hierarchy

biological process

multicellular organismal process [inference]

respiratory gaseous exchange by respiratory system

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GO Term	Evidence Code	PMID
alveolar lamellar body	IBA
multivesicular body lumen
lamellar body
extracellular region
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen [inference]

late endosome lumen [inference]

multivesicular body lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

lamellar body

alveolar lamellar body

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19815549 25416956 25910212 26871637 31515488 32296183
identical protein binding	IPI	25416956 25910212 31515488 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000168484

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K26068

Name

pulmonary surfactant-associated protein C

References

3035561

Disease

Disease Ontology

Displaying entries **1 - 10** of 93 in total

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DO ID	Disease Name	Source
DOID:0050156	idiopathic pulmonary fibrosis	DisGeNET DisGeNET DisGeNET DisGeNET DisGeNET
DOID:0050158	desquamative interstitial pneumonia	DisGeNET Alliance of Genome Resources
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET
DOID:0050848	obstructive sleep apnea	DisGeNET
DOID:0050997	cerebellar ataxia, mental retardation and dysequlibrium syndrome	DisGeNET
DOID:0060185	Clostridium difficile colitis	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0090119	ankyloblepharon-ectodermal defects-cleft lip/palate syndrome	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET

The Human Phenotype Ontology

Displaying entries **31 - 40** of 42 in total

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HPO ID	HPO Term
HP:0006530	Abnormal pulmonary interstitial morphology
HP:0006532	Recurrent pneumonia
HP:0010444	Pulmonary insufficiency
HP:0010702	Increased circulating antibody level
HP:0011947	Respiratory tract infection
HP:0012378	Fatigue
HP:0012418	Hypoxemia
HP:0012735	Cough
HP:0100598	Pulmonary edema
HP:0100750	Atelectasis

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:610913	surfactant metabolism dysfunction, pulmonary, 2
ORPHA:70587	respiratory distress syndrome in premature infants
OMIM:178500	interstitial lung disease 2
ORPHA:2032	interstitial lung disease 2

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2; SMDP2

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Tursiops truncatus	117312756		TURTR02135
Balaenoptera musculus	118896980		BALMU12986
Sus scrofa	733580		PIGXX06370
Bos taurus	282071		BOVIN34706
Capra hircus	102172442		CAPHI29266
Ovis aries	443034		SHEEP08934
Dipodomys ordii	105999426		DIPOR20135
Cricetulus griseus	100766762		CRIGR01635
Mus musculus	20389	MGI:109517	MOUSE13007
Rattus norvegicus	50683	RGD:3666	RATNO10369

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements