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alkaline ceramidase 3

Summary

Gene Symbol

Acer3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

66190

PubChem

66190

Alliance of Genome Resources

MGI:1913440

Annotation

Keyword

Calcium
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Metal-binding
Reference proteome
Sphingolipid metabolism
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D099	Alkaline phytoceramidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IEA ISO
regulation of programmed cell death	ISO ISS
myelination	ISO ISS
phytosphingosine biosynthetic process	IBA ISO ISS
ceramide catabolic process	IMP ISO ISS	26474409

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

diol metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

diol biosynthetic process [inference]

sphingosine biosynthetic process

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

diol biosynthetic process [inference]

sphingosine biosynthetic process

phytosphingosine biosynthetic process

cellular process [inference]

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process [inference]

sphingosine biosynthetic process

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	ISO
endoplasmic reticulum membrane	IBA ISO ISS
Golgi membrane	ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
zinc ion binding	ISO ISS
phytoceramidase activity
dihydroceramidase activity
ceramidase activity
N-acylsphingosine amidohydrolase activity	IBA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

N-acylsphingosine amidohydrolase activity

ceramidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

alkaline ceramidase 3

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
L: Replication, recombination and repair

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
N-acylsphingosine amidohydrolase activity
ceramide biosynthetic process
ceramide catabolic process
ceramide metabolic process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
hydrolase activity
lipid metabolic process
phytoceramidase activity
phytosphingosine biosynthetic process
sphingolipid metabolic process

Displaying 1 entry
InterPro
Alkaline ceramidase

Rhea

RHEA:20856

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:10579	leukodystrophy	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002416
Gene Name: alkaline ceramidase 3

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	55331		HGNC:16066	HUMAN08349
Rattus norvegicus	499210	10116_1:000819	RGD:1561254	RATNO18794
Danio rerio	555411		ZFIN:ZDB-GENE-091204-155	DANRE00351
Canis lupus familiaris	607939			CANLF08246
Bos taurus	615110			BOVIN07286
Macaca mulatta	697832			MACMU11231
Pan troglodytes	748831			PANTR03885
Saccharomyces cerevisiae S288C	852481		SGD:S000000387
Saccharomyces cerevisiae S288C	856018		SGD:S000006008
Monodelphis domestica	100027829			MONDO21431

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements