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proline-rich transmembrane protein 2

Summary

Gene Symbol

Prrt2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

69017

PubChem

69017

Alliance of Genome Resources

MGI:1916267

Annotation

Keyword

Cell membrane
Cell projection
Cytoplasmic vesicle
Methylation
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
E9PUL5	Dispanin subfamily B member 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of short-term synaptic potentiation	IMP	29056747
negative regulation of SNARE complex assembly	IMP	29056747
synaptic vesicle fusion to presynaptic active zone membrane	IMP	27052163
regulation of calcium-dependent activation of synaptic vesicle fusion	IDA IMP	27052163
neuromuscular process controlling posture	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

membrane organization [inference]

synaptic vesicle membrane organization [inference]

synaptic vesicle fusion to presynaptic active zone membrane

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

exocytic process [inference]

vesicle fusion to plasma membrane [inference]

synaptic vesicle fusion to presynaptic active zone membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling posture

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of short-term synaptic potentiation [inference]

negative regulation of short-term synaptic potentiation

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

negative regulation of protein-containing complex assembly [inference]

negative regulation of SNARE complex assembly

negative regulation of transport [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

negative regulation of short-term synaptic potentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of short-term synaptic potentiation [inference]

negative regulation of short-term synaptic potentiation

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of SNARE complex assembly

regulation of SNARE complex assembly [inference]

negative regulation of SNARE complex assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

negative regulation of protein-containing complex assembly [inference]

negative regulation of SNARE complex assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

regulation of vesicle fusion [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of SNARE complex assembly

regulation of SNARE complex assembly [inference]

negative regulation of SNARE complex assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

negative regulation of protein-containing complex assembly [inference]

negative regulation of SNARE complex assembly

regulation of synaptic vesicle membrane organization [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

negative regulation of vesicle fusion [inference]

negative regulation of SNARE complex assembly

regulation of synaptic vesicle fusion to presynaptic active zone membrane [inference]

regulation of calcium-dependent activation of synaptic vesicle fusion

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of short-term synaptic potentiation [inference]

negative regulation of short-term synaptic potentiation

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
axon terminus	IDA	29056747
synaptic vesicle membrane	IEA
membrane	IBA IDA	22101681
postsynaptic density membrane	IEA
presynapse	IDA	27052163 29056747

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

neuron projection terminus [inference]

axon terminus

presynapse

axon terminus

postsynapse [inference]

dendritic spine

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	27052163 29056747
SH3 domain binding	ISO	26797119
syntaxin-1 binding	IDA	29056747

GO Hierarchy

molecular function

binding [inference]

protein binding

SNARE binding [inference]

syntaxin binding [inference]

syntaxin-1 binding

protein domain specific binding [inference]

SH3 domain binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

proline-rich transmembrane protein 2

Functional Category

L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
CD225/Dispanin family

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081115	benign familial infantile seizures 2	Alliance of Genome Resources
DOID:0090053	episodic kinesigenic dyskinesia 1	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	112476		HGNC:30500	HUMAN27640
Rattus norvegicus	361651	10116_1:0008a1	RGD:1564195	RATNO17859
Macaca mulatta	709072			MACMU25930
Pan troglodytes	738350			PANTR12090
Equus caballus	100065869			HORSE07201
Danio rerio	100329612		ZFIN:ZDB-GENE-121210-3
Pongo abelii	100444066			PONAB10383
Ailuropoda melanoleuca	100471392			AILME04428
Nomascus leucogenys	100600812			NOMLE25857
Sus scrofa	100623439			PIGXX20633