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X-prolyl aminopeptidase 1

Summary

Gene Symbol

XPNPEP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7511

PubChem

7511

Alliance of Genome Resources

HGNC:12822

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Aminopeptidase
Cytoplasm
Direct protein sequencing
Hydrolase
Manganese
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9NQW7	Aminoacylproline aminopeptidase Cytosolic aminopeptidase P Soluble aminopeptidase P X-Pro aminopeptidase 1 X-prolyl aminopeptidase 1, soluble
Q5T6H7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
bradykinin catabolic process	IDA	18515364
proteolysis	IDA	11106490
negative regulation of programmed cell death	IDA	35165443

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

protein metabolic process [inference]

proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

protein metabolic process [inference]

proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process [inference]

bradykinin catabolic process

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death

negative regulation of cellular process [inference]

negative regulation of programmed cell death

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	IDA	11106490
cytoplasm	ISS
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
aminopeptidase activity	IDA	11106490
manganese ion binding	IDA	18515364
metalloaminopeptidase activity	IDA	18515364 35165443
protein homodimerization activity	IPI	18515364

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity [inference]

metalloaminopeptidase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aminopeptidase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
V: Defense mechanisms

Displaying **all 2** entries
Gene Ontology
aminopeptidase activity
metalloaminopeptidase activity

Displaying **all 6** entries
InterPro
Aminopeptidase P
Creatinase, N-terminal
Creatinase/Aminopeptidase P/Spt16, N-terminal
Creatinase/aminopeptidase-like
Peptidase M24, C-terminal domain
Peptidase M24

Ortholog

Displaying entries **11 - 20** of 81 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	850630		SGD:S000003952
Monodelphis domestica	100028140			MONDO04678
Ornithorhynchus anatinus	100082035			ORNAN07864
Sus scrofa	100152688			PIGXX08478
Taeniopygia guttata	100225725			TAEGU27460
Oryctolagus cuniculus	100342148			RABIT07013
Callithrix jacchus	100403473			CALJA07623
Pongo abelii	100457613	9601_0:002adc		PONAB01358
Ailuropoda melanoleuca	100472199			AILME06710
Meleagris gallopavo	100544719			MELGA12719

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements