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membrane bound O-acyltransferase domain containing 7

Summary

Gene Symbol

MBOAT7

Aliases

BB1
LPIAT1
LPLAT
LPLAT11
hMBOA-7
lysophosphatidylinositol acyltransferase
lysophosphatidylinositol acyltransferase 1
lysophospholipid acyltransferase 11
lysophospholipid acyltransferase 7

Organism

Homo sapiens (human)

External Links

NCBI Gene

79143

HGNC

15505

KEGG Gene ID

hsa:79143

PubChem

79143

Alliance of Genome Resources

HGNC:15505

Annotation

Keyword

3D-structure
Acyltransferase
Alternative splicing
Disease variant
Endoplasmic reticulum
Glycoprotein
Intellectual disability
Phospholipid biosynthesis
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96N66	1-acylglycerophosphatidylinositol O-acyltransferase Bladder and breast carcinoma-overexpressed gene 1 protein Leukocyte receptor cluster member 4 Lysophosphatidylinositol acyltransferase Membrane-bound O-acyltransferase domain-containing protein 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
layer formation in cerebral cortex	ISS
lipid modification	IBA
phosphatidylcholine acyl-chain remodeling	IDA	18772128
ventricular system development	IEA
phosphatidylinositol biosynthetic process	IBA IMP	18094042

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

layer formation in cerebral cortex

anatomical structure development [inference]

system development [inference]

ventricular system development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of triglyceride metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of triglyceride metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of triglyceride metabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	30959108
mitochondria-associated endoplasmic reticulum membrane	IBA IDA	23510452
endoplasmic reticulum membrane
membrane	HDA IBA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
1-acylglycerol-3-phosphate O-acyltransferase activity
O-acyltransferase activity	IDA IMP ISS	18094042 18772128
protein binding	IPI	21903422 23510452
2-acylglycerol-3-phosphate O-acyltransferase activity
lysophospholipid acyltransferase activity	IBA ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

2-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity

lysophosphatidic acid acyltransferase activity [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K13516

Name

lysophospholipid acyltransferase 7 [EC:2.3.1.-]

References

18772128

Disease

Disease Ontology

Displaying entries **11 - 20** of 53 in total

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DO ID	Disease Name	Source
DOID:1094	attention deficit hyperactivity disorder	DisGeNET
DOID:114	heart disease	DisGeNET
DOID:11832	visual epilepsy	DisGeNET DisGeNET DisGeNET
DOID:12139	dysthymic disorder	DisGeNET
DOID:12351	alcoholic hepatitis	DisGeNET
DOID:12849	autistic disorder	DisGeNET
DOID:12859	choreatic disease	DisGeNET
DOID:1287	cardiovascular system disease	DisGeNET
DOID:14018	alcoholic liver cirrhosis	DisGeNET DisGeNET
DOID:14159	obstructive hydrocephalus	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 18 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000729	Autistic behavior
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001263	Global developmental delay
HP:0001276	Hypertonia
HP:0001290	Generalized hypotonia
HP:0001344	Absent speech
HP:0001347	Hyperreflexia

Displaying 1 entry
Disease ID	Disease Name
OMIM:617188	intellectual disability, autosomal recessive 57

PubChem Disease

MedGen Diseases

Intellectual disability, autosomal recessive 57

OMIM Phenotypes

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 57; MRT57

KEGG Diseases

Autosomal recessive intellectual developmental disorder

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **21 - 30** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100408143	CALJA24453
Macaca mulatta	693742	MACMU19723
Gorilla gorilla gorilla	101146063	GORGO17075
Pan paniscus	100981053	PANPA21365
Pan troglodytes	107969800	PANTR19266
Pongo abelii	100457310	PONAB14621
Canis lupus familiaris	100683790	CANLF00666
Vulpes vulpes	112909412	VULVU35427
Ursus americanus	123786964	URSAM28682
Ailuropoda melanoleuca	100464529	AILME03788

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements