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post-GPI attachment to proteins inositol deacylase 1

Summary

Gene Symbol

PGAP1

Aliases

Bst1
FLJ12377
GPI inositol-deacylase
SPG67

Organism

Homo sapiens (human)

External Links

NCBI Gene

80055

HGNC

25712

KEGG Gene ID

hsa:80055

PubChem

80055

Alliance of Genome Resources

HGNC:25712

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Glycoprotein
Hydrolase
Intellectual disability
Protein transport
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q75T13	Post-GPI attachment to proteins factor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
positive regulation of ER to Golgi vesicle-mediated transport	ISS
embryonic pattern specification	IEA
sensory perception of sound	IEA
GPI anchor metabolic process	IBA
anterior/posterior axis specification	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

macromolecule modification [inference]

protein modification process [inference]

attachment of GPI anchor to protein

carbohydrate derivative metabolic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

cellular process [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

pattern specification process [inference]

regionalization [inference]

forebrain regionalization

axis specification [inference]

anterior/posterior axis specification

embryonic pattern specification

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA ISS
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phosphatidylinositol deacylase activity	IBA ISS
hydrolase activity, acting on ester bonds

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

carboxylic ester hydrolase activity [inference]

phosphatidylinositol deacylase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K05294

Name

GPI inositol-deacylase [EC:3.-.-.-]

References

14734546

Disease

Disease Ontology

Displaying entries **21 - 30** of 34 in total

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DO ID	Disease Name	Source
DOID:3327	partial motor epilepsy	DisGeNET
DOID:4090	agnosia	DisGeNET
DOID:4480	achondroplasia	DisGeNET
DOID:4621	holoprosencephaly	DisGeNET Alliance of Genome Resources
DOID:4964	neurotic disorder	DisGeNET
DOID:5212	congenital disorder of glycosylation	DisGeNET
DOID:543	dystonia	DisGeNET DisGeNET
DOID:8501	fundus dystrophy	DisGeNET
DOID:8584	Burkitt lymphoma	DisGeNET
DOID:8927	learning disability	DisGeNET

The Human Phenotype Ontology

Displaying entries **41 - 50** of 65 in total

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HPO ID	HPO Term
HP:0002188	Delayed CNS myelination
HP:0002342	Intellectual disability, moderate
HP:0002355	Difficulty walking
HP:0002553	Highly arched eyebrow
HP:0003202	Skeletal muscle atrophy
HP:0003487	Babinski sign
HP:0003593	Infantile onset
HP:0003700	Generalized amyotrophy
HP:0004322	Short stature
HP:0005280	Depressed nasal bridge

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:615802	intellectual disability, autosomal recessive 42
ORPHA:401820	autosomal recessive spastic paraplegia type 67

PubChem Disease

MedGen Diseases

Intellectual disability, autosomal recessive 42

OMIM Phenotypes

NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FEATURES, SPASTICITY, AND BRAIN ABNORMALITIES; NEDDSBA

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006714
Gene Name: post-GPI attachment to proteins 1

Ortholog

Displaying entries **21 - 30** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Gorilla gorilla gorilla	101145385	GORGO26440
Pan paniscus	100979650	PANPA26324
Pan troglodytes	745391	PANTR29419
Canis lupus familiaris	612828	CANLF14080
Vulpes vulpes	112922906	VULVU16194
Ursus americanus	123798162	URSAM10829
Ailuropoda melanoleuca	100478076	AILME11992
Mustela putorius furo	101681493	MUSPF04934
Felis catus	101083194	FELCA18362
Panthera leo	122226431	PANLE10861

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements