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glucose-6-phosphatase catalytic subunit 3

Summary

Gene Symbol

G6PC3

Aliases

UGRP

Organism

Homo sapiens (human)

External Links

NCBI Gene

92579

HGNC

24861

KEGG Gene ID

hsa:92579

PubChem

92579

Alliance of Genome Resources

HGNC:24861

Annotation

Keyword

Disease variant
Endoplasmic reticulum
Gluconeogenesis
Hydrolase
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A8Q3SIG5
Q9BUM1	Glucose-6-phosphatase beta Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
K7EJC5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glucose 6-phosphate metabolic process	IBA
glucose-6-phosphate transport	IEA
gluconeogenesis	IBA IEA TAS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

carbohydrate derivative metabolic process [inference]

glucose 6-phosphate metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

glucose 6-phosphate metabolic process

organophosphate metabolic process [inference]

glucose 6-phosphate metabolic process

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

organophosphate ester transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

carbohydrate derivative transport [inference]

hexose phosphate transport [inference]

glucose-6-phosphate transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	TAS
membrane	HDA IBA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
glucose-6-phosphatase activity	EXP IBA IMP TAS	14718531 25492228

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

sugar-terminal-phosphatase activity [inference]

glucose-6-phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01084

Name

glucose-6-phosphatase [EC:3.1.3.9]

References

19700406

Rhea

H₂O + D-glucose 6-phosphate

D-glucose + phosphate

Enzyme

PMID

H₂O + α-D-glucose 6-phosphate

α-D-glucose + phosphate

Enzyme

Disease

Disease Ontology

Displaying entries **31 - 40** of 72 in total

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DO ID	Disease Name	Source
DOID:11383	cryptorchidism	DisGeNET
DOID:11502	mitral valve insufficiency	DisGeNET
DOID:1227	neutropenia	DisGeNET DisGeNET
DOID:12450	pancytopenia	DisGeNET
DOID:12987	agranulocytosis	DisGeNET DisGeNET
DOID:13515	tuberous sclerosis	DisGeNET
DOID:13620	patent foramen ovale	DisGeNET DisGeNET DisGeNET
DOID:13832	patent ductus arteriosus	DisGeNET
DOID:14323	Marfan syndrome	DisGeNET
DOID:14557	primary pulmonary hypertension	DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 20** of 50 in total

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HPO ID	HPO Term
HP:0000388	Otitis media
HP:0000407	Sensorineural hearing impairment
HP:0000431	Wide nasal bridge
HP:0000768	Pectus carinatum
HP:0000778	Hypoplasia of the thymus
HP:0000954	Single transverse palmar crease
HP:0001015	Prominent superficial veins
HP:0001263	Global developmental delay
HP:0001433	Hepatosplenomegaly
HP:0001508	Failure to thrive

Displaying 1 entry
Disease ID	Disease Name
OMIM:612541	autosomal recessive severe congenital neutropenia due to G6PC3 deficiency

PubChem Disease

MedGen Diseases

Autosomal recessive severe congenital neutropenia due to G6PC3 deficiency

OMIM Phenotypes

NEUTROPENIA, SEVERE CONGENITAL, 4, AUTOSOMAL RECESSIVE; SCN4

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **21 - 30** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Macaca nemestrina	105469320		MACNE40099
Papio anubis	101003602		PAPAN14959
Mandrillus leucophaeus	105543793		MANLE25659
Gorilla gorilla gorilla	101128335		GORGO32403
Pan paniscus	100993144		PANPA16515
Pan troglodytes	454720		PANTR13758
Pongo abelii	100458617		PONAB12807
Vulpes vulpes	112910664		VULVU36764
Ailuropoda melanoleuca	100482095		AILME12242
Mustela putorius furo	101686925		MUSPF04780

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024