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phosphate cytidylyltransferase 1B, choline

Summary

Gene Symbol

PCYT1B

Aliases

CCT-beta
CCTbeta
CTB
CTP:phosphocholine cytidylyltransferase-beta
choline-phosphate cytidylyltransferase beta
phosphorylcholine transferase beta

Organism

Homo sapiens (human)

External Links

NCBI Gene

9468

HGNC

8755

KEGG Gene ID

hsa:9468

PubChem

9468

Alliance of Genome Resources

HGNC:8755

Annotation

Keyword

Alternative splicing
Cytoplasm
Endoplasmic reticulum
Nucleotidyltransferase
Phospholipid biosynthesis
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y5K3	CCT-beta CTP:phosphocholine cytidylyltransferase B Phosphorylcholine transferase B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ovarian follicle development	IEA
spermatogenesis	IEA
CDP-choline pathway	IDA	10480912
phosphatidylcholine biosynthetic process	IDA	10480912

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

reproductive process [inference]

developmental process involved in reproduction [inference]

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure development [inference]

ovarian follicle development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	10480912
cytoplasm		9593753
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
choline-phosphate cytidylyltransferase activity	IBA IDA	10480912
phosphatidylcholine binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

cytidylyltransferase activity [inference]

choline-phosphate cytidylyltransferase activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

ion binding [inference]

cation binding [inference]

phosphatidylcholine binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00968

Name

choline-phosphate cytidylyltransferase [EC:2.7.7.15]

References

7918629

Rhea

H⁺ + phosphocholine + CTP

diphosphate + CDP-choline

Enzyme

2.7.7.15

PMID

Disease

Disease Ontology

Displaying entries **41 - 50** of 53 in total

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DO ID	Disease Name	Source
DOID:4481	allergic rhinitis	DisGeNET
DOID:4730	vasomotor rhinitis	DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5162	arteriolosclerosis	DisGeNET DisGeNET
DOID:5200	urinary tract obstruction	DisGeNET
DOID:5672	large intestine cancer	DisGeNET
DOID:676	juvenile rheumatoid arthritis	DisGeNET
DOID:684	hepatocellular carcinoma	DisGeNET DisGeNET
DOID:686	liver carcinoma	DisGeNET
DOID:8577	ulcerative colitis	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001639
Gene Name: phosphate cytidylyltransferase 1, choline, beta

Ortholog

Displaying entries **21 - 30** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Sarcophilus harrisii	100923586		SARHA10639
Callithrix jacchus	100388909		CALJA46935
Cercocebus atys	105574608		CERAT03660
Macaca fascicularis	102119838		MACFA43983
Macaca mulatta	701760		MACMU46982
Macaca nemestrina	105478244		MACNE09527
Papio anubis	101007668		PAPAN42171
Mandrillus leucophaeus	105545188		MANLE17035
Gorilla gorilla gorilla	101142777		GORGO43125
Pan paniscus	100995988		PANPA41056

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Last updated: August 19, 2024