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heparan sulfate-glucosamine 3-sulfotransferase 1

Summary

Gene Symbol

HS3ST1

Aliases

3OST1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9957

GGDB ID

gg014

HGNC

5194

mRNA

NM_005114

map

4p16

Protein

NP_005105

OMIM

603244

KEGG Gene ID

hsa:9957

PubChem

9957

Alliance of Genome Resources

HGNC:5194

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Golgi apparatus
Reference proteome
Signal
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
O14792	Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glycosaminoglycan biosynthetic process	IDA	8900198 9988768
heparan sulfate proteoglycan biosynthetic process, enzymatic modification

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process, enzymatic modification

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sulfotransferase activity		9988767
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	IBA IDA TAS	8900198 9988768

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring sulphur-containing groups [inference]

sulfotransferase activity

heparan sulfate sulfotransferase activity [inference]

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000002587

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg014

Gene Symbol

HS3ST1

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Rattus norvegicus	NP_445843	NM_053391
Caenorhabditis elegans	NP_495230	NM_062829
Mus musculus	NP_034604	NM_010474

KEGG BRITE Database

Orthology

K01024

Name

[heparan sulfate]-glucosamine 3-sulfotransferase 1 [EC:2.8.2.23]

References

9346953

Rhea

3'-phosphoadenylyl sulfate

H⁺ + adenosine 3',5'-bisphosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **11 - 20** of 25 in total

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DO ID	Disease Name	Source
DOID:0110047	Alzheimer's disease 14	DisGeNET
DOID:0110048	Alzheimer's disease 15	DisGeNET
DOID:10652	Alzheimer's disease	DisGeNET
DOID:11870	Pick's disease	DisGeNET
DOID:1443	cerebral degeneration	DisGeNET
DOID:14525	Reye syndrome	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1936	atherosclerosis	DisGeNET DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET
DOID:2349	arteriosclerosis	DisGeNET DisGeNET

Ortholog

Displaying entries **21 - 30** of 95 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callithrix jacchus	100392281		CALJA29443
Cercocebus atys	105579062		CERAT09379
Macaca mulatta	713374		MACMU36822
Macaca nemestrina	105487944		MACNE04603
Papio anubis	101008842		PAPAN27963
Mandrillus leucophaeus	105545063		MANLE18674
Gorilla gorilla gorilla	101134668		GORGO30474
Pan paniscus	100967734		PANPA29899
Pan troglodytes	471144		PANTR33335
Pongo abelii	100449950		PONAB28182

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024