G01614ZM

Summary
GlyTouCan ID
G01614ZM
IUPAC Condensed
Neu5Ac(a2-3)Gal(b1-3)[Neu5Ac(a2-6)]GalNAc(a1-
Motifs
Di-sialyl T antigen
Subsumption Level
Fully-defined saccharide
Monoisotopic Mass
965.33
3D Structures
GlycoShape
G01614ZM
Displaying 1 entry
Archetype α β
G30110UW
G01614ZM
G04267XF
Organisms
Taxonomic Hierarchy
GlycoGene Database (GGDB)
Displaying all 5 entries
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
R
G01614ZM
R
ST6GALNAC2 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC3 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC1 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
Displaying entries 1 - 5 of 6 in total
Gene Symbol Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
R
G01614ZM
R
ST6GALNAC2 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
ST6GALNAC4 CMP-Neu5Ac
G65562ZE
benzyl
G01614ZM
benzyl
ST6GALNAC3 CMP-Neu5Ac
G65562ZE
Ser/Thr
G01614ZM
Ser/Thr
KEGG BRITE Database
KEGG ID
Enzyme
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05914
GlycoEpitope
Epitope ID
EP0023
GlycomeAtlas

Tissues in which this glycan is expressed are highlighted in yellow.

Danio rerio
Brain Gill Heart Intestine Intestine Liver Ovary Skin Testis
Literature
Tissue
  • brain
  • gill
  • heart
  • intestine
  • liver
  • skin gland
  • testis
Reference
Yamakawa N et al. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nat Commun. 2018;9(1):4647. Published 2018 Nov 7. doi:10.1038/s41467-018-06950-3
DOI
10.1038/s41467-018-06950-3
Sequence Descriptors
GlycoCT
RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
6b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
7s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(3+2)4d
4:4d(5+1)5n
5:1o(6+2)6d
6:6d(5+1)7n
WURCS
WURCS=2.0/3,4,3/[a2112h-1a_1-5_2*NCC/3=O][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3-3/a3-b1_a6-d2_b3-c2
Literature
Displaying entries 31 - 40 of 103 in total
PubMed ID Title First Author Publication Date Source
9449027 Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma Elliott MM 1997 Aug
  • GlyGen
  • PubChem
8942648 Peptide, Disulfide, and Glycosylation Mapping of Recombinant Human Thrombopoietin from Ser1 to Arg246 Hoffman RC 1996 Jan 01
  • GlyGen
  • PubChem
8969192 Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines. Demonstration of simpler and fewer glycan chains in tumor cells Lloyd KO 1996 Dec 27
  • GlyGen
  • PubChem
7737204 Structural Analysis of the Sialylated N- and O-Linked Carbohydrate Chains of Recombinant Human Erythropoietin Expressed in Chinese Hamster Ovary Cells. Sialylation Patterns and Branch Location of Dimeric N-acetyllactosamine Units Hokke CH 1995 Mar 15
  • GlyGen
  • PubChem
8034632 Sialylation and sulfation of the carbohydrate chains in respiratory mucins from a patient with cystic fibrosis Lo-Guidice JM 1994 Jul 22
  • GlyGen
7509790 Common tetrasaccharide epitope NeuAc alpha 2-->3Gal beta 1-->3(Neu-Ac alpha 2-->6)GalNAc, presented by different carrier glycosylceramides or O-linked peptides, is recognized by different antibodies and ligands having distinct specificities Saito S 1994 Feb 25
  • GlyGen
  • GlycoEpitope
8054720 Structure determination of the intact major sialylated oligosaccharide chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells Watson E 1994 Apr
  • GlyGen
  • PubChem
8460945 Structures of Mucin-Type Sugar Chains on Human Erythropoietins Purified from Urine and the Culture Medium of Recombinant Chinese Hamster Ovary Cells Inoue N 1993 Mar
  • GlyGen
  • PubChem
8345526 Crystallographic Refinement and Structure Analysis of the Complex of Wheat Germ Agglutinin with a Bivalent Sialoglycopeptide from Glycophorin A Wright CS 1993 Jul 20
  • PubChem
8344280 Biosynthesis and secretion of human interleukin 2 glycoprotein variants from baculovirus-infected Sf21 cells. Characterization of polypeptides and posttranslational modifications Grabenhorst E 1993 Jul 01
  • GlyGen
  • PubChem
PubAnnotation
Displaying all 4 entries
Title Authors Source Publication Date PubMed ID
Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes.
  • Fuseya S
  • Izumi H
  • Hamano A
  • Murakami Y
  • Suzuki R
  • Koiwai R
  • Hayashi T
  • Kuno A
  • Takahashi S
  • Kudo T
Sci Rep 2023 Jun 29 37386100
Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.
  • Sim L
  • Thompson N
  • Geissner A
  • Withers SG
  • Wakarchuk WW
Glycobiology 2022 Apr 21 34939113
Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
  • Ohmi Y
  • Nishikaze T
  • Kitaura Y
  • Ito T
  • Yamamoto S
  • Sugiyama F
  • Matsuyama M
  • Takahashi Y
  • Takeda A
  • Kawahara T
  • Okajima T
  • Furukawa K
  • Furukawa K
Glycobiology 2021 Jun 3 33242079
Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro.
  • Vyas AA
  • Blixt O
  • Paulson JC
  • Schnaar RL
J Biol Chem 2005 Apr 22 15701648

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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