6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

Summary
UniProt ID
O60825
Gene Symbol
  • PFKFB2
Organism
Homo sapiens (human)
External Links
GlyGen
O60825
PubChem
O60825
The Human Metabolome Database
HMDBP00804
The O-GlcNAc Database
O60825
O-GlcNAcAtlas
O60825
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Alternative splicing
  • Hydrolase
  • Kinase
  • Multifunctional enzyme
  • Phosphoprotein
  • Reference proteome
Gene Ontology (GO)
Sequence
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYSVGSRPLKPLSPLRAQDMQEGAD
Glycosylation Sites
Displaying all 5 entries
Position Description PubMed ID GlyTouCan ID Source
11
390
471
472
475
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying 1 entry
Pathway Name Organism
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Homo sapiens
Disease
Displaying entries 11 - 15 of 15 in total
DO ID Disease Name Source
DOID:3891 placental insufficiency
DOID:4766 embryoma
DOID:8923 skin melanoma
DOID:9351 diabetes mellitus
DOID:9352 type 2 diabetes mellitus

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024