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MIRAGE
Spike glycoprotein

Summary
UniProt ID
P0DTC2
Gene Symbol
  • 2
  • S
Organism
Severe acute respiratory syndrome coronavirus 2
GlyConnect
GlyGen
P0DTC2
PubChem
P0DTC2
Re-Glyco
P0DTC2
Annotation
Keyword
  • 3D-structure
  • Coiled coil
  • Disulfide bond
  • Fusion of virus membrane with host endosomal membrane
  • Glycoprotein
  • Host cell membrane
  • Inhibition of host tetherin by virus
  • Palmitate
  • Reference proteome
  • Signal
  • Superantigen
  • Transmembrane helix
  • Viral attachment to host cell
  • Viral envelope protein
  • Virulence
Gene Ontology (GO)
Displaying all 8 entries
GO Term
plasma membrane
membrane
viral envelope
host cell plasma membrane
host cell endoplasmic reticulum-Golgi intermediate compartment membrane
virion membrane
host cell surface
host extracellular space
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entry 11 - 11 of 11 in total
GO Term
suppression by virus of host tetherin activity
Annotation information from UniProt.
Sequence
MFVFLVLLPLVSSQCVNLTTRTQLPPAYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVYYHKNNKSWMESEFRVYSSANNCTFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHRSYLTPGDSSSGWTAGAAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVAIHADQLTPTWRVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPRRARSVASQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIVMVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 41 - 50 of 55 in total
Position Description PubMed ID GlyTouCan ID Source
801 N-linked (GlcNAc...) (hybrid) asparagine; by host
803
1074 N-linked (GlcNAc...) (hybrid) asparagine; by host
1076
1077
1097
1098 N-linked (GlcNAc...) (complex) asparagine; by host
1100
1134 N-linked (GlcNAc...) (complex) asparagine; by host
1158 N-linked (GlcNAc...) (complex) asparagine; by host
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 6 entries
Pathway Name Organism
Attachment and Entry Homo sapiens
Induction of Cell-Cell Fusion Homo sapiens
Maturation of spike protein Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses Homo sapiens
Translation of Structural Proteins Homo sapiens
Virion Assembly and Release Homo sapiens
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025