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Major prion protein

Summary

UniProt ID

P40244

Gene Symbol

PRNP
PRP

Organism

Neogale vison (American mink)

External Links

PubChem: P40244

Annotation

Keyword

Cell membrane
Copper
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Reference proteome
Repeat
Signal
Zinc

Gene Ontology (GO)

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GO Term
regulation of potassium ion transmembrane transport
negative regulation of amyloid-beta formation
negative regulation of dendritic spine maintenance
cellular response to amyloid-beta
regulation of calcium ion import across plasma membrane
negative regulation of protein phosphorylation

Displaying entries **1 - 10** of 11 in total

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GO Term
cytosol
membrane raft
endoplasmic reticulum
cell surface
side of membrane
Golgi apparatus
plasma membrane
nuclear membrane
terminal bouton
dendrite

Displaying entries **1 - 10** of 14 in total

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GO Term
microtubule binding
signaling receptor activity
protein-containing complex binding
aspartic-type endopeptidase inhibitor activity
type 5 metabotropic glutamate receptor binding
identical protein binding
molecular function activator activity
amyloid-beta binding
copper ion binding
molecular condensate scaffold activity

Annotation information from UniProt.

Sequence

MVKSHIGSWLLVLFVATWSDIGFCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGGSHGQWGKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYKPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDMKIMERVVEQMCVTQYQRESEAYYQRGASAILFSPPPVILLISLLILLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites