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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Summary
- UniProt ID
- Q16875
- Gene Symbol
-
- PFKFB3
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q16875
- PubChem
- Q16875
- The Human Metabolome Database
- HMDBP00796
- The O-GlcNAc Database
- Q16875
- O-GlcNAcAtlas
- Q16875
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Hydrolase
- Kinase
- Multifunctional enzyme
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| fructose metabolic process |
| fructose 2,6-bisphosphate metabolic process |
| GO Term |
|---|
| cytosol |
| nucleoplasm |
| GO Term |
|---|
| fructose-2,6-bisphosphate 2-phosphatase activity |
| ATP binding |
| 6-phosphofructo-2-kinase activity |
Sequence
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 171 |
|
|||
| 172 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Regulation of glycolysis by fructose 2,6-bisphosphate metabolism | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110756 | type 1 diabetes mellitus 19 | |
| DOID:0110757 | type 1 diabetes mellitus 20 | |
| DOID:0110758 | type 1 diabetes mellitus 21 | |
| DOID:0110759 | type 1 diabetes mellitus 22 | |
| DOID:0110760 | type 1 diabetes mellitus 23 | |
| DOID:0110761 | type 1 diabetes mellitus 24 | |
| DOID:0111095 | Fanconi anemia complementation group A | |
| DOID:10127 | cerebral artery occlusion | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma |
