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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Heparanase
Summary
- UniProt ID
- Q6YGZ1
- Gene Symbol
-
- Hpse
- Hpa
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0005896
- PubChem
- Q6YGZ1
Annotation
- Keyword
-
- Calcium
- Cell adhesion
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Hydrolase
- Lysosome
- Magnesium
- Membrane
- Nucleus
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| receptor-mediated endocytosis |
| cell-matrix adhesion |
| positive regulation of vascular endothelial growth factor production |
| establishment of endothelial barrier |
| vascular wound healing |
| GO Term |
|---|
| membrane raft |
| nucleoplasm |
| lysosomal lumen |
| extracellular space |
| nucleus |
| lysosomal membrane |
| plasma membrane |
| extracellular matrix |
| GO Term |
|---|
| cargo receptor ligand activity |
| heparanase activity |
| syndecan binding |
Sequence
MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSLPAFSYGFFVIRNAKIAACI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 192 | N-linked (GlcNAc...) asparagine |
|
||
| 209 | N-linked (GlcNAc...) asparagine |
|
||
| 451 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG degradation | Mus musculus |
| Neutrophil degranulation | Mus musculus |
