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Phosphatidylcholine-sterol acyltransferase

Summary

UniProt ID

P04180

Gene Symbol

LCAT

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011357

GlyConnect

GlyGen

P04180

PubChem

P04180

SwissLipids

SLP:000000660

The Human Metabolome Database

HMDBP00069

Annotation

Keyword

3D-structure
Acyltransferase
Cholesterol metabolism
Corneal dystrophy
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

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GO Term
lipid metabolic process
lipoprotein biosynthetic process
regulation of high-density lipoprotein particle assembly
reverse cholesterol transport
phospholipid metabolic process
cholesterol metabolic process
cholesterol homeostasis
phosphatidylcholine biosynthetic process
cholesterol transport
very-low-density lipoprotein particle remodeling

Displaying **all 4** entries
GO Term
extracellular region
extracellular space
extracellular exosome
high-density lipoprotein particle

Displaying **all 5** entries
GO Term
platelet-activating factor acetyltransferase activity
1-alkyl-2-acetylglycerophosphocholine esterase activity
phosphatidylcholine-sterol O-acyltransferase activity
sterol esterase activity
apolipoprotein A-I binding

Annotation information from UniProt.

Sequence

MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
44		23586699
296		23586699

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
HDL remodeling	Homo sapiens

Disease

Displaying entries **91 - 100** of **150** in total

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DO ID	Disease Name	Source
DOID:10966	lipoid nephrosis	DisGeNET
DOID:11342	arcus senilis	DisGeNET
DOID:114	heart disease	DisGeNET
DOID:11541	recurrent corneal erosion	DisGeNET
DOID:1168	familial hyperlipidemia	DisGeNET DisGeNET DisGeNET
DOID:1171	hyperlipoproteinemia type V	DisGeNET
DOID:1184	nephrotic syndrome	DisGeNET
DOID:11847	coronary thrombosis	DisGeNET
DOID:11870	Pick's disease	DisGeNET
DOID:12318	granular corneal dystrophy	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements