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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Prosaposin
Summary
- UniProt ID
- P07602
- Gene Symbol
-
- PSAP
- GLBA
- SAP1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011421
- GlyConnect
- GlyGen
- P07602
- PubChem
- P07602
- The Human Metabolome Database
- HMDBP01673
- The O-GlcNAc Database
- P07602
- RaftProt
- P07602
- O-GlcNAcAtlas
- P07602
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Gangliosidosis
- Gaucher disease
- Glycoprotein
- Lysosome
- Metachromatic leukodystrophy
- Neurodegeneration
- Parkinson disease
- Parkinsonism
- Reference proteome
- Repeat
- Secreted
- Signal
- Sphingolipid metabolism
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| lysosome |
| lysosomal membrane |
| plasma membrane |
| intracellular membrane-bounded organelle |
| collagen-containing extracellular matrix |
| azurophil granule membrane |
| extracellular exosome |
| late endosome |
| GO Term |
|---|
| ganglioside GP1c binding |
- Site Annotations
| Position | Description |
|---|---|
| 215 | Not glycosylated; in variant MLDSAPB Ile-217 |
Sequence
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| G alpha (i) signalling events | Homo sapiens |
| Glycosphingolipid catabolism | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Peptide ligand-binding receptors | Homo sapiens |
| Platelet degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110573 | autosomal dominant nonsyndromic deafness 4A | |
| DOID:0110574 | autosomal dominant nonsyndromic deafness 4B | |
| DOID:0110575 | autosomal dominant nonsyndromic deafness 5 | |
| DOID:0110576 | autosomal dominant nonsyndromic deafness 50 | |
| DOID:0110577 | autosomal dominant nonsyndromic deafness 51 | |
| DOID:0110578 | autosomal dominant nonsyndromic deafness 52 | |
| DOID:0110579 | autosomal dominant nonsyndromic deafness 53 | |
| DOID:0110580 | autosomal dominant nonsyndromic deafness 54 | |
| DOID:0110581 | autosomal dominant nonsyndromic deafness 56 | |
| DOID:0110582 | autosomal dominant nonsyndromic deafness 58 |
