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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Prosaposin
Summary
- UniProt ID
- P07602
- Gene Symbol
-
- PSAP
- GLBA
- SAP1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011421
- GlyConnect
- GlyGen
- P07602
- PubChem
- P07602
- The Human Metabolome Database
- HMDBP01673
- The O-GlcNAc Database
- P07602
- RaftProt
- P07602
- O-GlcNAcAtlas
- P07602
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Gangliosidosis
- Gaucher disease
- Glycoprotein
- Lysosome
- Metachromatic leukodystrophy
- Neurodegeneration
- Parkinson disease
- Parkinsonism
- Reference proteome
- Repeat
- Secreted
- Signal
- Sphingolipid metabolism
- Gene Ontology (GO)
| GO Term |
|---|
| intracellular membrane-bounded organelle |
| collagen-containing extracellular matrix |
| azurophil granule membrane |
| extracellular exosome |
| late endosome |
| lysosomal lumen |
| extracellular region |
| extracellular space |
| lysosome |
| lysosomal membrane |
- Site Annotations
| Position | Description |
|---|---|
| 215 | Not glycosylated; in variant MLDSAPB Ile-217 |
Sequence
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| G alpha (i) signalling events | Homo sapiens |
| Glycosphingolipid catabolism | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Peptide ligand-binding receptors | Homo sapiens |
| Platelet degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110463 | autosomal recessive nonsyndromic deafness 102 | |
| DOID:0110464 | autosomal recessive nonsyndromic deafness 103 | |
| DOID:0110465 | autosomal recessive nonsyndromic deafness 104 | |
| DOID:0110466 | obsolete autosomal recessive nonsyndromic deafness 105 | |
| DOID:0110467 | autosomal recessive nonsyndromic deafness 12 | |
| DOID:0110468 | autosomal recessive nonsyndromic deafness 13 | |
| DOID:0110469 | autosomal recessive nonsyndromic deafness 14 | |
| DOID:0110470 | autosomal recessive nonsyndromic deafness 15 | |
| DOID:0110471 | autosomal recessive nonsyndromic deafness 16 | |
| DOID:0110472 | autosomal recessive nonsyndromic deafness 17 |
