GlyCosmos Portal

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Insulin receptor

Summary

UniProt ID

P15208

Gene Symbol

Insr

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003397

GlyConnect

2393

GlyGen

P15208

PubChem

P15208

The O-GlcNAc Database

P15208

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Endosome
Glycoprotein
Lysosome
Phosphoprotein
Receptor
Reference proteome
Repeat
S-nitrosylation
Signal
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **11 - 20** of 44 in total

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GO Term
positive regulation of cell migration
positive regulation of phosphorylation
glucose homeostasis
regulation of embryonic development
positive regulation of glycoprotein biosynthetic process
adrenal gland development
exocrine pancreas development
response to nutrient levels
positive regulation of protein-containing complex disassembly
positive regulation of nitric oxide biosynthetic process

Displaying entries **1 - 10** of 17 in total

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GO Term
caveola
endosome
late endosome
nuclear envelope
lysosome
plasma membrane
insulin receptor complex
membrane
axon
nuclear lumen

Displaying entries **1 - 10** of 20 in total

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GO Term
cargo receptor activity
insulin binding
protein-containing complex binding
protein kinase binding
PTB domain binding
protein domain specific binding
lipoic acid binding
insulin-like growth factor I binding
insulin-like growth factor II binding
3-phosphoinositide-dependent protein kinase binding

Annotation information from UniProt.

Sequence

MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
138		17406563 22823882
242		22823882
282
364		23002422
424
445		17406563 22823882 23002422
700		22823882 23002422
759		22823882
772		22823882
910		17406563 22823882 23002422

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
IRS activation	Mus musculus
Insulin receptor recycling	Mus musculus
Insulin receptor signalling cascade	Mus musculus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Mus musculus
Signal attenuation	Mus musculus
Signaling by Insulin receptor	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements