[ { "pathway_label": "Eicosanoids", "protein_name": "[{\"label\":\"7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase\",\"id\":\"Q9UNU6\"},{\"label\":\"Cytochrome P450 4A11\",\"id\":\"Q02928\"},{\"label\":\"Cytochrome P450 4A22\",\"id\":\"Q5TCH4\"},{\"label\":\"Cytochrome P450 4B1\",\"id\":\"P13584\"},{\"label\":\"Cytochrome P450 4F11\",\"id\":\"Q9HBI6\"},{\"label\":\"Cytochrome P450 4F12\",\"id\":\"Q9HCS2\"},{\"label\":\"Cytochrome P450 4F2\",\"id\":\"P78329\"},{\"label\":\"Cytochrome P450 4F3\",\"id\":\"Q08477\"},{\"label\":\"Cytochrome P450 4F8\",\"id\":\"P98187\"},{\"label\":\"Prostacyclin synthase\",\"id\":\"Q16647\"},{\"label\":\"Thromboxane-A synthase\",\"id\":\"P24557\"},{\"label\":\"Ultra-long-chain fatty acid omega-hydroxylase\",\"id\":\"Q6NT55\"}]", "uniprot_id": "[\"P13584\",\"P24557\",\"P78329\",\"P98187\",\"Q02928\",\"Q08477\",\"Q16647\",\"Q5TCH4\",\"Q6NT55\",\"Q9HBI6\",\"Q9HCS2\",\"Q9UNU6\"]", "gene_symbol": 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factor IIE subunit 1\",\"id\":\"P29083\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"Integrator complex subunit 10\",\"id\":\"Q9NVR2\"},{\"label\":\"Integrator complex subunit 11\",\"id\":\"Q5TA45\"},{\"label\":\"Integrator complex subunit 12\",\"id\":\"Q96CB8\"},{\"label\":\"Integrator complex subunit 13\",\"id\":\"Q9NVM9\"},{\"label\":\"Integrator complex subunit 14\",\"id\":\"Q96SY0\"},{\"label\":\"Integrator complex subunit 1\",\"id\":\"Q8N201\"},{\"label\":\"Integrator complex subunit 2\",\"id\":\"Q9H0H0\"},{\"label\":\"Integrator complex subunit 3\",\"id\":\"Q68E01\"},{\"label\":\"Integrator complex subunit 4\",\"id\":\"Q96HW7\"},{\"label\":\"Integrator complex subunit 5\",\"id\":\"Q6P9B9\"},{\"label\":\"Integrator complex subunit 6\",\"id\":\"Q9UL03\"},{\"label\":\"Integrator complex subunit 7\",\"id\":\"Q9NVH2\"},{\"label\":\"Integrator complex subunit 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"gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by LTK in cancer", "protein_name": "[{\"label\":\"CAP-Gly domain-containing linker protein 1\",\"id\":\"P30622\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"}]", "uniprot_id": "[\"O00459\",\"P27361\",\"P27986\",\"P28482\",\"P30622\",\"P42336\",\"P42338\"]", "gene_symbol": "[\"CLIP1\",\"CYLN1\",\"ERK1\",\"ERK2\",\"GRB1\",\"MAPK1\",\"MAPK3\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3R1\",\"PIK3R2\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"RSN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective MTRR causes HMAE", "protein_name": "[{\"label\":\"Methionine synthase reductase\",\"id\":\"Q9UBK8\"},{\"label\":\"Methionine synthase\",\"id\":\"Q99707\"}]", "uniprot_id": "[\"Q99707\",\"Q9UBK8\"]", "gene_symbol": "[\"MTR\",\"MTRR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Coenzyme A biosynthesis", "protein_name": "[{\"label\":\"Bifunctional coenzyme A synthase\",\"id\":\"Q13057\"},{\"label\":\"Dephospho-CoA kinase domain-containing protein\",\"id\":\"Q8WVC6\"},{\"label\":\"Pantothenate kinase 1\",\"id\":\"Q8TE04\"},{\"label\":\"Pantothenate kinase 2, mitochondrial\",\"id\":\"Q9BZ23\"},{\"label\":\"Pantothenate kinase 3\",\"id\":\"Q9H999\"},{\"label\":\"Phosphopantothenate--cysteine ligase\",\"id\":\"Q9HAB8\"},{\"label\":\"Phosphopantothenoylcysteine decarboxylase\",\"id\":\"Q96CD2\"}]", "uniprot_id": "[\"Q13057\",\"Q8TE04\",\"Q8WVC6\",\"Q96CD2\",\"Q9BZ23\",\"Q9H999\",\"Q9HAB8\"]", "gene_symbol": "[\"C20orf48\",\"COAB\",\"COAC\",\"COASY\",\"DCAKD\",\"PANK\",\"PANK1\",\"PANK2\",\"PANK3\",\"PPCDC\",\"PPCS\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MPS II - Hunter syndrome", "protein_name": "[{\"label\":\"Iduronate 2-sulfatase\",\"id\":\"P22304\"}]", "uniprot_id": "[\"P22304\"]", "gene_symbol": "[\"IDS\",\"SIDS\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)", "protein_name": "[{\"label\":\"Sodium/potassium/calcium exchanger 1\",\"id\":\"O60721\"}]", "uniprot_id": "[\"O60721\"]", "gene_symbol": "[\"KIAA0702\",\"NCKX1\",\"SLC24A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PI3K events in ERBB2 signaling", "protein_name": "[{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"O14511\",\"O14944\",\"P00533\",\"P01133\",\"P04626\",\"P27986\",\"P35070\",\"P42336\",\"P56975\",\"Q02297\",\"Q13480\",\"Q8WWG1\",\"Q99075\"]", "gene_symbol": 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5B\",\"id\":\"Q14865\"},{\"label\":\"Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6\",\"id\":\"Q6NYC1\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone demethylase UTY\",\"id\":\"O14607\"},{\"label\":\"Histone lysine demethylase PHF8\",\"id\":\"Q9UPP1\"},{\"label\":\"Lysine-specific demethylase 2A\",\"id\":\"Q9Y2K7\"},{\"label\":\"Lysine-specific demethylase 2B\",\"id\":\"Q8NHM5\"},{\"label\":\"Lysine-specific demethylase 3A\",\"id\":\"Q9Y4C1\"},{\"label\":\"Lysine-specific demethylase 3B\",\"id\":\"Q7LBC6\"},{\"label\":\"Lysine-specific demethylase 4A\",\"id\":\"O75164\"},{\"label\":\"Lysine-specific demethylase 4B\",\"id\":\"O94953\"},{\"label\":\"Lysine-specific demethylase 4C\",\"id\":\"Q9H3R0\"},{\"label\":\"Lysine-specific demethylase 4D\",\"id\":\"Q6B0I6\"},{\"label\":\"Lysine-specific demethylase 5A\",\"id\":\"P29375\"},{\"label\":\"Lysine-specific demethylase 5B\",\"id\":\"Q9UGL1\"},{\"label\":\"Lysine-specific demethylase 5C\",\"id\":\"P41229\"},{\"label\":\"Lysine-specific demethylase 5D\",\"id\":\"Q9BY66\"},{\"label\":\"Lysine-specific demethylase 6A\",\"id\":\"O15550\"},{\"label\":\"Lysine-specific demethylase 6B\",\"id\":\"O15054\"},{\"label\":\"Lysine-specific demethylase 7A\",\"id\":\"Q6ZMT4\"},{\"label\":\"Lysine-specific demethylase PHF2\",\"id\":\"O75151\"},{\"label\":\"Lysine-specific histone demethylase 1A\",\"id\":\"O60341\"},{\"label\":\"Lysine-specific histone demethylase 2\",\"id\":\"Q8NB78\"},{\"label\":\"Ribosomal oxygenase 2\",\"id\":\"Q8IUF8\"}]", "uniprot_id": "[\"O14607\",\"O15054\",\"O15550\",\"O60341\",\"O75151\",\"O75164\",\"O94953\",\"P29375\",\"P41229\",\"P62805\",\"P68431\",\"Q14865\",\"Q6B0I6\",\"Q6NYC1\",\"Q6ZMT4\",\"Q71DI3\",\"Q7LBC6\",\"Q8IUF8\",\"Q8NB78\",\"Q8NHM5\",\"Q9BY66\",\"Q9H3R0\",\"Q9UGL1\",\"Q9UPP1\",\"Q9Y2K7\",\"Q9Y4C1\"]", "gene_symbol": 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acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone-arginine methyltransferase CARM1\",\"id\":\"Q86X55\"},{\"label\":\"M-phase inducer phosphatase 3\",\"id\":\"P30307\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Protein arginine N-methyltransferase 1\",\"id\":\"Q99873\"},{\"label\":\"Retinoblastoma-like protein 1\",\"id\":\"P28749\"},{\"label\":\"Retinoblastoma-like protein 2\",\"id\":\"Q08999\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F4\",\"id\":\"Q16254\"},{\"label\":\"Zinc finger protein 385A\",\"id\":\"Q96PM9\"}]", "uniprot_id": "[\"O14965\",\"P04637\",\"P06493\",\"P12004\",\"P14635\",\"P24522\",\"P28749\",\"P30307\",\"P31947\",\"Q07812\",\"Q08999\",\"Q09472\",\"Q14186\",\"Q14188\",\"Q16254\",\"Q86X55\",\"Q96PM9\",\"Q99873\"]", "gene_symbol": 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H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Interleukin-7 receptor subunit alpha\",\"id\":\"P16871\"},{\"label\":\"Interleukin-7\",\"id\":\"P13232\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Suppressor of cytokine signaling 1\",\"id\":\"O15524\"},{\"label\":\"Suppressor of cytokine signaling 2\",\"id\":\"O14508\"},{\"label\":\"Thymic stromal 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175\",\"id\":\"P19214\"},{\"label\":\"Fibronectin\",\"id\":\"P02751\"},{\"label\":\"Glycophorin-A\",\"id\":\"P02724\"},{\"label\":\"Glycophorin-B\",\"id\":\"P06028\"},{\"label\":\"Glycophorin-C\",\"id\":\"P04921\"},{\"label\":\"Glypican-1\",\"id\":\"P35052\"},{\"label\":\"Golgi apparatus protein 1\",\"id\":\"Q92896\"},{\"label\":\"Growth arrest-specific protein 6\",\"id\":\"Q14393\"},{\"label\":\"HLA class II histocompatibility antigen gamma chain\",\"id\":\"P04233\"},{\"label\":\"High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor\",\"id\":\"Q8WWV6\"},{\"label\":\"High affinity immunoglobulin epsilon receptor subunit gamma\",\"id\":\"P30273\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin J chain\",\"id\":\"P01591\"},{\"label\":\"Immunoglobulin heavy constant alpha 1\",\"id\":\"P01876\"},{\"label\":\"Immunoglobulin heavy constant alpha 2\",\"id\":\"P01877\"},{\"label\":\"Immunoglobulin heavy constant 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1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 3\",\"id\":\"P0DOY3\"},{\"label\":\"Immunoglobulin lambda constant 6\",\"id\":\"P0CF74\"},{\"label\":\"Immunoglobulin lambda constant 7\",\"id\":\"A0M8Q6\"},{\"label\":\"Immunoglobulin lambda variable 1-40\",\"id\":\"P01703\"},{\"label\":\"Immunoglobulin lambda variable 1-44\",\"id\":\"P01699\"},{\"label\":\"Immunoglobulin lambda variable 1-47\",\"id\":\"P01700\"},{\"label\":\"Immunoglobulin lambda variable 1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 2-8\",\"id\":\"P01709\"},{\"label\":\"Immunoglobulin lambda variable 3-19\",\"id\":\"P01714\"},{\"label\":\"Immunoglobulin lambda variable 3-1\",\"id\":\"P01715\"},{\"label\":\"Immunoglobulin lambda variable 3-21\",\"id\":\"P80748\"},{\"label\":\"Immunoglobulin lambda variable 3-25\",\"id\":\"P01717\"},{\"label\":\"Immunoglobulin lambda variable 3-27\",\"id\":\"P01718\"},{\"label\":\"Immunoglobulin lambda variable 6-57\",\"id\":\"P01721\"},{\"label\":\"Immunoglobulin lambda variable 7-43\",\"id\":\"P04211\"},{\"label\":\"Immunoglobulin lambda-like polypeptide 1\",\"id\":\"P15814\"},{\"label\":\"Immunolglobulin kappa light chain variable region L22 (Fragment)\",\"id\":\"A2NXD2\"},{\"label\":\"Integrin alpha-4\",\"id\":\"P13612\"},{\"label\":\"Integrin alpha-5\",\"id\":\"P08648\"},{\"label\":\"Integrin alpha-L\",\"id\":\"P20701\"},{\"label\":\"Integrin alpha-M\",\"id\":\"P11215\"},{\"label\":\"Integrin alpha-X\",\"id\":\"P20702\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin beta-2\",\"id\":\"P05107\"},{\"label\":\"Junctional adhesion molecule A\",\"id\":\"Q9Y624\"},{\"label\":\"Junctional adhesion molecule B\",\"id\":\"P57087\"},{\"label\":\"Junctional adhesion molecule C\",\"id\":\"Q9BX67\"},{\"label\":\"Junctional adhesion molecule-like\",\"id\":\"Q86YT9\"},{\"label\":\"L-selectin\",\"id\":\"P14151\"},{\"label\":\"Leukocyte surface antigen CD47\",\"id\":\"Q08722\"},{\"label\":\"Leukosialin\",\"id\":\"P16150\"},{\"label\":\"Lymphocyte function-associated antigen 3\",\"id\":\"P19256\"},{\"label\":\"Macrophage migration inhibitory factor\",\"id\":\"P14174\"},{\"label\":\"Natural killer cell receptor 2B4\",\"id\":\"Q9BZW8\"},{\"label\":\"Opacity protein V28 (Fragment)\",\"id\":\"P11297\"},{\"label\":\"Opacity protein opA50 (Fragment)\",\"id\":\"P11296\"},{\"label\":\"Opacity protein opA51 (Fragment)\",\"id\":\"Q04874\"},{\"label\":\"Opacity protein opA52 (Fragment)\",\"id\":\"Q04875\"},{\"label\":\"Opacity protein opA53 (Fragment)\",\"id\":\"Q04876\"},{\"label\":\"Opacity protein opA54\",\"id\":\"Q04877\"},{\"label\":\"Opacity protein opA55 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molecule\",\"id\":\"P16284\"},{\"label\":\"Platelet factor 4 variant\",\"id\":\"P10720\"},{\"label\":\"Platelet factor 4\",\"id\":\"P02776\"},{\"label\":\"Platelet glycoprotein VI\",\"id\":\"Q9HCN6\"},{\"label\":\"Pre-B lymphocyte protein 3\",\"id\":\"Q9UKI3\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 11\",\"id\":\"Q9UQ72\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 1\",\"id\":\"P11464\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 2\",\"id\":\"P11465\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 3\",\"id\":\"Q16557\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 4\",\"id\":\"Q00888\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 5\",\"id\":\"Q15238\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 6\",\"id\":\"Q00889\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 7\",\"id\":\"Q13046\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 8\",\"id\":\"Q9UQ74\"},{\"label\":\"Pregnancy-specific beta-1-glycoprotein 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superfamily member 10D\",\"id\":\"Q9UBN6\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase Mer\",\"id\":\"Q12866\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type substrate 1\",\"id\":\"P78324\"},{\"label\":\"UGa8H (Fragment)\",\"id\":\"A2KUC3\"},{\"label\":\"V1-11 protein (Fragment)\",\"id\":\"Q5NV67\"},{\"label\":\"V1-13 protein (Fragment)\",\"id\":\"Q5NV69\"},{\"label\":\"V1-16 protein (Fragment)\",\"id\":\"Q5NV81\"},{\"label\":\"V1-20 protein (Fragment)\",\"id\":\"Q5NV86\"},{\"label\":\"V1-3 protein (Fragment)\",\"id\":\"Q5NV84\"},{\"label\":\"V1-5 protein (Fragment)\",\"id\":\"Q5NV65\"},{\"label\":\"V1-7 protein (Fragment)\",\"id\":\"Q5NV89\"},{\"label\":\"V1-9 protein (Fragment)\",\"id\":\"Q5NV66\"},{\"label\":\"V2-11 protein (Fragment)\",\"id\":\"Q5NV64\"},{\"label\":\"V2-15 protein (Fragment)\",\"id\":\"Q5NV75\"},{\"label\":\"V2-17 protein (Fragment)\",\"id\":\"Q5NV90\"},{\"label\":\"V2-19 protein (Fragment)\",\"id\":\"Q5NV91\"},{\"label\":\"V2-8 protein (Fragment)\",\"id\":\"Q5NV85\"},{\"label\":\"V3-2 protein (Fragment)\",\"id\":\"Q5NV80\"},{\"label\":\"V3-3 protein (Fragment)\",\"id\":\"Q5NV83\"},{\"label\":\"V3-4 protein (Fragment)\",\"id\":\"Q5NV62\"},{\"label\":\"V4-1 protein (Fragment)\",\"id\":\"Q5NV68\"},{\"label\":\"V4-2 protein (Fragment)\",\"id\":\"Q5NV82\"},{\"label\":\"V4-6 protein (Fragment)\",\"id\":\"Q5NV87\"},{\"label\":\"V5-1 protein (Fragment)\",\"id\":\"Q5NV61\"},{\"label\":\"V5-4 protein (Fragment)\",\"id\":\"Q5NV79\"},{\"label\":\"V5-6 protein (Fragment)\",\"id\":\"Q5NV92\"},{\"label\":\"Vitamin K-dependent protein C\",\"id\":\"P04070\"},{\"label\":\"Vitamin K-dependent protein S\",\"id\":\"P07225\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Uncoating of the HIV Virion", "protein_name": "[{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Protein Nef\",\"id\":\"P04601\"},{\"label\":\"Protein Rev\",\"id\":\"P04618\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"P04585\",\"P04591\",\"P04601\",\"P04618\",\"P05919\",\"P62937\",\"P69723\",\"P69726\"]", "gene_symbol": "[\"CYPA\",\"PPIA\",\"gag\",\"gag-pol\",\"nef\",\"rev\",\"vif\",\"vpr\",\"vpu\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SUMOylation of SUMOylation proteins", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase PIAS4\",\"id\":\"Q8N2W9\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"E3 ubiquitin-protein ligase Topors\",\"id\":\"Q9NS56\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"},{\"label\":\"Small ubiquitin-related modifier 2\",\"id\":\"P61956\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": "[\"A8CG34\",\"O15504\",\"O75694\",\"P12270\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P55735\",\"P57740\",\"P61956\",\"P63165\",\"P63279\",\"P78406\",\"Q12769\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8N1F7\",\"Q8N2W9\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q96HA1\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9NRG9\",\"Q9NS56\",\"Q9UKX7\"]", "gene_symbol": 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alpha-2,6-sialyltransferase\",\"id\":\"Q9H4F1\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2\",\"id\":\"Q9UJ37\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3\",\"id\":\"Q8NDV1\"},{\"label\":\"Beta-galactoside alpha-2,6-sialyltransferase 1\",\"id\":\"P15907\"},{\"label\":\"CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase\",\"id\":\"Q11203\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1\",\"id\":\"Q11201\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2\",\"id\":\"Q16842\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4\",\"id\":\"Q11206\"},{\"label\":\"ORF3a protein\",\"id\":\"P59632\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 1\",\"id\":\"Q10472\"}]", "uniprot_id": "[\"P15907\",\"P59632\",\"Q10472\",\"Q11201\",\"Q11203\",\"Q11206\",\"Q16842\",\"Q8NDV1\",\"Q9H4F1\",\"Q9UJ37\"]", "gene_symbol": "[\"3a\",\"CGS23\",\"GALNT1\",\"NANTA3\",\"SIAT1\",\"SIAT3C\",\"SIAT4\",\"SIAT4A\",\"SIAT4B\",\"SIAT4C\",\"SIAT6\",\"SIAT7B\",\"SIAT7C\",\"SIAT7D\",\"SIATL1\",\"ST3GAL1\",\"ST3GAL2\",\"ST3GAL3\",\"ST3GAL4\",\"ST6GAL1\",\"ST6GALNAC2\",\"ST6GALNAC3\",\"ST6GALNAC4\",\"STHM\",\"STZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "cGMP effects", "protein_name": "[{\"label\":\"Calcium-activated potassium channel subunit alpha-1\",\"id\":\"Q12791\"},{\"label\":\"Calcium-activated potassium channel subunit beta-1\",\"id\":\"Q16558\"},{\"label\":\"Calcium-activated potassium channel subunit beta-2\",\"id\":\"Q9Y691\"},{\"label\":\"Calcium-activated potassium channel subunit beta-3\",\"id\":\"Q9NPA1\"},{\"label\":\"Calcium-activated potassium channel subunit beta-4\",\"id\":\"Q86W47\"},{\"label\":\"Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A\",\"id\":\"Q9HCR9\"},{\"label\":\"Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A\",\"id\":\"P54750\"},{\"label\":\"Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B\",\"id\":\"Q01064\"},{\"label\":\"High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A\",\"id\":\"O76083\"},{\"label\":\"Inositol 1,4,5-triphosphate receptor associated 1\",\"id\":\"Q9Y6F6\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1\",\"id\":\"Q14643\"},{\"label\":\"cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A\",\"id\":\"Q9Y233\"},{\"label\":\"cGMP-dependent 3',5'-cyclic phosphodiesterase\",\"id\":\"O00408\"},{\"label\":\"cGMP-dependent protein kinase 2\",\"id\":\"Q13237\"},{\"label\":\"cGMP-specific 3',5'-cyclic phosphodiesterase\",\"id\":\"O76074\"}]", "uniprot_id": "[\"O00408\",\"O76074\",\"O76083\",\"P54750\",\"Q01064\",\"Q12791\",\"Q13237\",\"Q14643\",\"Q16558\",\"Q86W47\",\"Q9HCR9\",\"Q9NPA1\",\"Q9Y233\",\"Q9Y691\",\"Q9Y6F6\"]", "gene_symbol": "[\"INSP3R1\",\"IRAG\",\"IRAG1\",\"ITPR1\",\"JAW1L\",\"KCNMA\",\"KCNMA1\",\"KCNMB1\",\"KCNMB2\",\"KCNMB3\",\"KCNMB4\",\"KCNMBL\",\"MRVI1\",\"PDE10A\",\"PDE11A\",\"PDE1A\",\"PDE1B\",\"PDE2A\",\"PDE5\",\"PDE5A\",\"PDE9A\",\"PDES1B\",\"PRKG2\",\"PRKGR2\",\"SLO\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective F8 binding to von Willebrand factor", "protein_name": "[{\"label\":\"Coagulation factor VIII\",\"id\":\"P00451\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"P00451\",\"P04275\"]", "gene_symbol": "[\"F8\",\"F8C\",\"F8VWF\",\"VWF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components", "protein_name": "[{\"label\":\"Cell division cycle protein 20 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1\",\"id\":\"P16444\"},{\"label\":\"Dipeptidase 2\",\"id\":\"Q9H4A9\"},{\"label\":\"Glutathione hydrolase 1 proenzyme\",\"id\":\"P19440\"},{\"label\":\"Glutathione hydrolase 5 proenzyme\",\"id\":\"P36269\"}]", "uniprot_id": "[\"P16444\",\"P19440\",\"P36269\",\"Q9H4A9\",\"Q9NS75\",\"Q9Y271\"]", "gene_symbol": "[\"CYSLT1\",\"CYSLT2\",\"CYSLT2R\",\"CYSLTR1\",\"CYSLTR2\",\"DPEP1\",\"DPEP2\",\"GGT\",\"GGT1\",\"GGT5\",\"GGTLA1\",\"MDP\",\"RDP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "mRNA decay by 3' to 5' exoribonuclease", "protein_name": "[{\"label\":\"7-methylguanosine phosphate-specific 5'-nucleotidase\",\"id\":\"Q969T7\"},{\"label\":\"Exosome complex component CSL4\",\"id\":\"Q9Y3B2\"},{\"label\":\"Exosome complex component MTR3\",\"id\":\"Q5RKV6\"},{\"label\":\"Exosome complex component RRP40\",\"id\":\"Q9NQT5\"},{\"label\":\"Exosome complex component RRP41\",\"id\":\"Q9NPD3\"},{\"label\":\"Exosome complex component RRP42\",\"id\":\"Q15024\"},{\"label\":\"Exosome complex component RRP43\",\"id\":\"Q96B26\"},{\"label\":\"Exosome complex component RRP45\",\"id\":\"Q06265\"},{\"label\":\"Exosome complex component RRP46\",\"id\":\"Q9NQT4\"},{\"label\":\"Exosome complex component RRP4\",\"id\":\"Q13868\"},{\"label\":\"Exosome complex exonuclease RRP44\",\"id\":\"Q9Y2L1\"},{\"label\":\"HBS1-like protein\",\"id\":\"Q9Y450\"},{\"label\":\"Superkiller complex protein 2\",\"id\":\"Q15477\"},{\"label\":\"Superkiller complex protein 3\",\"id\":\"Q6PGP7\"},{\"label\":\"Superkiller complex protein 8\",\"id\":\"Q9GZS3\"},{\"label\":\"m7GpppX diphosphatase\",\"id\":\"Q96C86\"}]", "uniprot_id": "[\"Q06265\",\"Q13868\",\"Q15024\",\"Q15477\",\"Q5RKV6\",\"Q6PGP7\",\"Q969T7\",\"Q96B26\",\"Q96C86\",\"Q9GZS3\",\"Q9NPD3\",\"Q9NQT4\",\"Q9NQT5\",\"Q9Y2L1\",\"Q9Y3B2\",\"Q9Y450\"]", "gene_symbol": "[\"CML28\",\"CSL4\",\"DCPS\",\"DCS1\",\"DDX13\",\"DIS3\",\"EXOSC1\",\"EXOSC2\",\"EXOSC3\",\"EXOSC4\",\"EXOSC5\",\"EXOSC6\",\"EXOSC7\",\"EXOSC8\",\"EXOSC9\",\"HBS1\",\"HBS1L\",\"HINT5\",\"KIAA0116\",\"KIAA0372\",\"KIAA1008\",\"KIAA1038\",\"MTR3\",\"NT5C3B\",\"NT5C3L\",\"OIP2\",\"PMSCL1\",\"RRP4\",\"RRP40\",\"RRP41\",\"RRP42\",\"RRP43\",\"RRP44\",\"RRP46\",\"SKI2W\",\"SKI6\",\"SKIC2\",\"SKIC3\",\"SKIC8\",\"SKIV2\",\"SKIV2L\",\"TTC37\",\"W\",\"WDR61\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)", "protein_name": "[{\"label\":\"Ceruloplasmin\",\"id\":\"P00450\"},{\"label\":\"Ferroportin\",\"id\":\"Q9NP59\"}]", "uniprot_id": "[\"P00450\",\"Q9NP59\"]", "gene_symbol": "[\"CP\",\"FPN\",\"FPN1\",\"IREG1\",\"SLC11A3\",\"SLC40A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Downstream TCR signaling", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase 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"gtc_id": "[\"\"]" }, { "pathway_label": "TGFBR3 regulates activin signaling", "protein_name": "[{\"label\":\"Activin receptor type-2A\",\"id\":\"P27037\"},{\"label\":\"Inhibin alpha chain\",\"id\":\"P05111\"},{\"label\":\"Inhibin beta A chain\",\"id\":\"P08476\"},{\"label\":\"Transforming growth factor beta receptor type 3\",\"id\":\"Q03167\"}]", "uniprot_id": "[\"P05111\",\"P08476\",\"P27037\",\"Q03167\"]", "gene_symbol": "[\"ACVR2\",\"ACVR2A\",\"INHA\",\"INHBA\",\"TGFBR3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Malate-aspartate shuttle", "protein_name": "[{\"label\":\"Aspartate aminotransferase, cytoplasmic\",\"id\":\"P17174\"},{\"label\":\"Aspartate aminotransferase, mitochondrial\",\"id\":\"P00505\"},{\"label\":\"Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial\",\"id\":\"O75746\"},{\"label\":\"Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial\",\"id\":\"Q9UJS0\"},{\"label\":\"Malate dehydrogenase, cytoplasmic\",\"id\":\"P40925\"},{\"label\":\"Malate dehydrogenase, mitochondrial\",\"id\":\"P40926\"},{\"label\":\"Mitochondrial 2-oxoglutarate/malate carrier protein\",\"id\":\"Q02978\"},{\"label\":\"Mitochondrial glutamate carrier 1\",\"id\":\"Q9H936\"},{\"label\":\"Mitochondrial glutamate carrier 2\",\"id\":\"Q9H1K4\"}]", "uniprot_id": "[\"O75746\",\"P00505\",\"P17174\",\"P40925\",\"P40926\",\"Q02978\",\"Q9H1K4\",\"Q9H936\",\"Q9UJS0\"]", "gene_symbol": "[\"AGC1\",\"ARALAR1\",\"GC1\",\"GC2\",\"GOT1\",\"GOT2\",\"KYAT4\",\"MDH1\",\"MDH2\",\"MDHA\",\"SLC20A4\",\"SLC25A11\",\"SLC25A12\",\"SLC25A13\",\"SLC25A18\",\"SLC25A22\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Relaxin receptors", "protein_name": "[{\"label\":\"Insulin-like 3\",\"id\":\"P51460\"},{\"label\":\"Insulin-like peptide INSL5\",\"id\":\"Q9Y5Q6\"},{\"label\":\"Prorelaxin H2\",\"id\":\"P04090\"},{\"label\":\"Relaxin receptor 1\",\"id\":\"Q9HBX9\"},{\"label\":\"Relaxin receptor 2\",\"id\":\"Q8WXD0\"},{\"label\":\"Relaxin-3 receptor 1\",\"id\":\"Q9NSD7\"},{\"label\":\"Relaxin-3 receptor 2\",\"id\":\"Q8TDU9\"},{\"label\":\"Relaxin-3\",\"id\":\"Q8WXF3\"}]", "uniprot_id": "[\"P04090\",\"P51460\",\"Q8TDU9\",\"Q8WXD0\",\"Q8WXF3\",\"Q9HBX9\",\"Q9NSD7\",\"Q9Y5Q6\"]", "gene_symbol": "[\"GPCR135\",\"GPCR142\",\"GPR100\",\"GPR106\",\"GREAT\",\"INSL3\",\"INSL5\",\"INSL7\",\"LGR7\",\"LGR8\",\"RLF\",\"RLN2\",\"RLN3\",\"RLN3R1\",\"RLN3R2\",\"RLNL\",\"RXFP1\",\"RXFP2\",\"RXFP3\",\"RXFP4\",\"RXN3\",\"SALPR\",\"ZINS4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RAC3 GTPase cycle", "protein_name": "[{\"label\":\"ARF GTPase-activating protein GIT1\",\"id\":\"Q9Y2X7\"},{\"label\":\"ARF GTPase-activating protein GIT2\",\"id\":\"Q14161\"},{\"label\":\"Abl interactor 1\",\"id\":\"Q8IZP0\"},{\"label\":\"Abl interactor 2\",\"id\":\"Q9NYB9\"},{\"label\":\"Actin remodeling regulator NHS\",\"id\":\"Q6T4R5\"},{\"label\":\"Actin-binding protein 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chain\",\"id\":\"P04839\"},{\"label\":\"Cytochrome b-245 light chain\",\"id\":\"P13498\"},{\"label\":\"Cytoplasmic FMR1-interacting protein 1\",\"id\":\"Q7L576\"},{\"label\":\"DEP domain-containing protein 1B\",\"id\":\"Q8WUY9\"},{\"label\":\"Dedicator of cytokinesis protein 10\",\"id\":\"Q96BY6\"},{\"label\":\"Delta(14)-sterol reductase LBR\",\"id\":\"Q14739\"},{\"label\":\"Desmoglein-2\",\"id\":\"Q14126\"},{\"label\":\"Emerin\",\"id\":\"P50402\"},{\"label\":\"Ephrin type-A receptor 2\",\"id\":\"P29317\"},{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Extended synaptotagmin-1\",\"id\":\"Q9BSJ8\"},{\"label\":\"Fermitin family homolog 2\",\"id\":\"Q96AC1\"},{\"label\":\"Granule associated Rac and RHOG effector protein 1\",\"id\":\"O15063\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Inner nuclear membrane protein Man1\",\"id\":\"Q9Y2U8\"},{\"label\":\"Inositol polyphosphate 5-phosphatase OCRL\",\"id\":\"Q01968\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Interleukin-32\",\"id\":\"P24001\"},{\"label\":\"Lamina-associated polypeptide 2, isoforms beta/gamma\",\"id\":\"P42167\"},{\"label\":\"MAGUK p55 subfamily member 7\",\"id\":\"Q5T2T1\"},{\"label\":\"Membrane-associated progesterone receptor component 2\",\"id\":\"O15173\"},{\"label\":\"NADPH oxidase 1\",\"id\":\"Q9Y5S8\"},{\"label\":\"NADPH oxidase 3\",\"id\":\"Q9HBY0\"},{\"label\":\"NADPH oxidase activator 1\",\"id\":\"Q86UR1\"},{\"label\":\"NADPH oxidase organizer 1\",\"id\":\"Q8NFA2\"},{\"label\":\"Nck-associated protein 1-like\",\"id\":\"P55160\"},{\"label\":\"Nck-associated protein 1\",\"id\":\"Q9Y2A7\"},{\"label\":\"Neutral amino acid transporter B(0)\",\"id\":\"Q15758\"},{\"label\":\"Neutrophil cytosol factor 1\",\"id\":\"P14598\"},{\"label\":\"Neutrophil cytosol factor 2\",\"id\":\"P19878\"},{\"label\":\"Neutrophil cytosol factor 4\",\"id\":\"Q15080\"},{\"label\":\"Oligophrenin-1\",\"id\":\"O60890\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Protein BRICK1\",\"id\":\"Q8WUW1\"},{\"label\":\"Protein ERGIC-53\",\"id\":\"P49257\"},{\"label\":\"Protein diaphanous homolog 3\",\"id\":\"Q9NSV4\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Rac GTPase-activating protein 1\",\"id\":\"Q9H0H5\"},{\"label\":\"Ragulator complex protein LAMTOR1\",\"id\":\"Q6IAA8\"},{\"label\":\"Rap guanine nucleotide exchange factor 1\",\"id\":\"Q13905\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 3\",\"id\":\"P60763\"},{\"label\":\"Ras-related protein Rab-7a\",\"id\":\"P51149\"},{\"label\":\"Rho GDP-dissociation inhibitor 2\",\"id\":\"P52566\"},{\"label\":\"Rho GTPase-activating protein 15\",\"id\":\"Q53QZ3\"},{\"label\":\"Rho GTPase-activating protein 17\",\"id\":\"Q68EM7\"},{\"label\":\"Rho GTPase-activating protein 1\",\"id\":\"Q07960\"},{\"label\":\"Rho GTPase-activating protein 21\",\"id\":\"Q5T5U3\"},{\"label\":\"Rho GTPase-activating protein 26\",\"id\":\"Q9UNA1\"},{\"label\":\"Rho GTPase-activating protein 32\",\"id\":\"A7KAX9\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho GTPase-activating protein 39\",\"id\":\"Q9C0H5\"},{\"label\":\"Rho GTPase-activating protein 42\",\"id\":\"A6NI28\"},{\"label\":\"Rho GTPase-activating protein 5\",\"id\":\"Q13017\"},{\"label\":\"Rho GTPase-activating protein 6\",\"id\":\"O43182\"},{\"label\":\"Rho GTPase-activating protein SYDE1\",\"id\":\"Q6ZW31\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM1\",\"id\":\"Q13009\"},{\"label\":\"SLIT and NTRK-like protein 3\",\"id\":\"O94933\"},{\"label\":\"SLIT and NTRK-like protein 5\",\"id\":\"O94991\"},{\"label\":\"SLIT-ROBO Rho GTPase-activating protein 2\",\"id\":\"O75044\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 4\",\"id\":\"O96013\"},{\"label\":\"Serine/threonine-protein kinase TAO3\",\"id\":\"Q9H2K8\"},{\"label\":\"Serine/threonine-protein kinase VRK2\",\"id\":\"Q86Y07\"},{\"label\":\"Starch-binding domain-containing protein 1\",\"id\":\"O95210\"},{\"label\":\"Switch-associated protein 70\",\"id\":\"Q9UH65\"},{\"label\":\"Synaptobrevin homolog YKT6\",\"id\":\"O15498\"},{\"label\":\"Synaptosomal-associated protein 23\",\"id\":\"O00161\"},{\"label\":\"Transferrin receptor protein 1\",\"id\":\"P02786\"},{\"label\":\"Triple functional domain protein\",\"id\":\"O75962\"},{\"label\":\"Tyrosine-protein kinase ABL2\",\"id\":\"P42684\"},{\"label\":\"Vang-like protein 1\",\"id\":\"Q8TAA9\"},{\"label\":\"Vesicle-associated membrane protein 3\",\"id\":\"Q15836\"}]", 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"gene_symbol": "[\"ABI1\",\"ABI2\",\"ABL2\",\"ABLL\",\"ABR\",\"ALI1\",\"AMIGO2\",\"ARAP2\",\"ARAP3\",\"ARG\",\"ARGBPIA\",\"ARHGAP1\",\"ARHGAP10\",\"ARHGAP15\",\"ARHGAP17\",\"ARHGAP21\",\"ARHGAP26\",\"ARHGAP32\",\"ARHGAP34\",\"ARHGAP35\",\"ARHGAP39\",\"ARHGAP42\",\"ARHGAP5\",\"ARHGAP6\",\"ARHGDIB\",\"ASCT2\",\"BAIAP2\",\"BAIAP2L1\",\"BCR\",\"BCR1\",\"BORG5\",\"BRK1\",\"C11orf59\",\"C3orf10\",\"CAV\",\"CAV1\",\"CDC42\",\"CDC42EP1\",\"CDC42GAP\",\"CDHF5\",\"CENTD1\",\"CENTD3\",\"CEP1\",\"CYBA\",\"CYBB\",\"CYFIP1\",\"D22S11\",\"DBL\",\"DEPDC1B\",\"DG6\",\"DIAP3\",\"DIAPH3\",\"DOCK10\",\"DPK\",\"DSG2\",\"ECK\",\"EDMD\",\"EMD\",\"EPHA2\",\"ERBB2IP\",\"ERBIN\",\"ERGIC53\",\"ESYT1\",\"F5F8D\",\"FAM62A\",\"FERMT2\",\"FNBP2\",\"FNRB\",\"GARRE1\",\"GDIA2\",\"GDID4\",\"GIT1\",\"GIT2\",\"GRAF\",\"GRAF3\",\"GRB1\",\"GRF1\",\"GRF2\",\"GRIT\",\"GRLF1\",\"HEM1\",\"HEM2\",\"IL32\",\"IRTKS\",\"ITGB1\",\"JAG1\",\"JAGL1\",\"JIK\",\"KDS\",\"KIAA0068\",\"KIAA0148\",\"KIAA0269\",\"KIAA0355\",\"KIAA0456\",\"KIAA0580\",\"KIAA0587\",\"KIAA0621\",\"KIAA0640\",\"KIAA0694\",\"KIAA0712\",\"KIAA0747\",\"KIAA0848\",\"KIAA0918\",\"KIAA1142\",\"KIAA1225\",\"KIAA1415\",\"KIAA1424\",\"KIAA1478\",\"KIAA1688\",\"KIAA1722\",\"KIND2\",\"LAMTOR1\",\"LAP2\",\"LBR\",\"LEMD3\",\"LMAN1\",\"LRRC11\",\"M7V1\",\"MAN1\",\"MAP3K18\",\"MBC2\",\"MCAM\",\"MCF2\",\"MDF2\",\"MGCRACGAP\",\"MIG2\",\"MOX1\",\"MOX2\",\"MPP7\",\"MSE55\",\"MSK12\",\"MUC18\",\"NAP1\",\"NCF1\",\"NCF2\",\"NCF4\",\"NCKAP1\",\"NCKAP1L\",\"NHS\",\"NK4\",\"NOH1\",\"NOX1\",\"NOX2\",\"NOX3\",\"NOXA1\",\"NOXA2\",\"NOXO1\",\"NOXO2\",\"OCRL\",\"OCRL1\",\"OPHN1\",\"OPHN1L\",\"P190A\",\"P41NOX\",\"P51NOX\",\"P67PHOX\",\"PAK1\",\"PAK2\",\"PAK4\",\"PDRO\",\"PGRMC2\",\"PIK3R1\",\"PIK3R2\",\"PLEKHC1\",\"PMBP\",\"PREX1\",\"RAB7\",\"RAB7A\",\"RAC3\",\"RACGAP1\",\"RAP1GN1\",\"RAPGEF1\",\"RDR\",\"RDRC\",\"RHOGAP1\",\"RHOGAP5\",\"RHOGAP6\",\"RICH1\",\"RICS\",\"SCAR1\",\"SH3PXD1A\",\"SH3PXD4\",\"SH3PXD5\",\"SLC1A5\",\"SLITRK3\",\"SLITRK5\",\"SNAP23\",\"SRGAP2\",\"SRGAP2A\",\"SSH3BP1\",\"STA\",\"STB2\",\"STBD1\",\"SWAP70\",\"SYB3\",\"SYDE1\",\"TAIF\",\"TAOK3\",\"TFRC\",\"TIAM1\",\"TMEM133\",\"TMPO\",\"TRIO\",\"VAMP3\",\"VANGL1\",\"VAV2\",\"VRK2\",\"WASF1\",\"WASF2\",\"WAVE1\",\"WAVE2\",\"XTP8\",\"YKT6\",\"ZIZ3\",\"p190ARHOGAP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by ERBB2 TMD/JMD mutants", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O14511\",\"O14944\",\"P00533\",\"P01111\",\"P01112\",\"P01133\",\"P04626\",\"P07900\",\"P19174\",\"P29353\",\"P35070\",\"P56975\",\"Q02297\",\"Q07889\",\"Q16543\",\"Q8WWG1\",\"Q96RT1\",\"Q99075\"]", "gene_symbol": "[\"BTC\",\"CDC37\",\"CDC37A\",\"DTR\",\"DTS\",\"EGF\",\"EGFR\",\"ERBB\",\"ERBB1\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"EREG\",\"GGF\",\"HBEGF\",\"HEGFL\",\"HER1\",\"HER2\",\"HGL\",\"HRAS\",\"HRAS1\",\"HRGA\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NDF\",\"NEU\",\"NGL\",\"NRAS\",\"NRG1\",\"NRG2\",\"NRG3\",\"NRG4\",\"NTAK\",\"PLC1\",\"PLCG1\",\"SHC\",\"SHC1\",\"SHCA\",\"SMDF\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "protein_name": "[{\"label\":\"1-acyl-sn-glycerol-3-phosphate acyltransferase beta\",\"id\":\"O15120\"},{\"label\":\"Acyl-CoA synthetase short-chain family member 3, mitochondrial\",\"id\":\"Q9H6R3\"},{\"label\":\"Adiponectin\",\"id\":\"Q15848\"},{\"label\":\"Angiopoietin-related protein 4\",\"id\":\"Q9BY76\"},{\"label\":\"CCAAT/enhancer-binding protein alpha\",\"id\":\"P49715\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Cyclin-C\",\"id\":\"P24863\"},{\"label\":\"Cyclin-dependent kinase 5\",\"id\":\"Q00535\"},{\"label\":\"Cyclin-dependent kinase 8\",\"id\":\"P49336\"},{\"label\":\"Diacylglycerol O-acyltransferase 2\",\"id\":\"Q96PD7\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Fatty acid-binding protein, adipocyte\",\"id\":\"P15090\"},{\"label\":\"G protein pathway suppressor 2\",\"id\":\"Q13227\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 1, mitochondrial\",\"id\":\"Q9HCL2\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H3.3\",\"id\":\"P84243\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone-lysine N-methyltransferase 2C\",\"id\":\"Q8NEZ4\"},{\"label\":\"Histone-lysine N-methyltransferase 2D\",\"id\":\"O14686\"},{\"label\":\"Hormone-sensitive lipase\",\"id\":\"Q05469\"},{\"label\":\"LIM domain-containing protein ajuba\",\"id\":\"Q96IF1\"},{\"label\":\"Lipid transferase CIDEC\",\"id\":\"Q96AQ7\"},{\"label\":\"Lipoprotein lipase\",\"id\":\"P06858\"},{\"label\":\"Long-chain-fatty-acid--CoA ligase 1\",\"id\":\"P33121\"},{\"label\":\"Lysine-specific demethylase 6A\",\"id\":\"O15550\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 10\",\"id\":\"Q9BTT4\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 12\",\"id\":\"Q93074\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 13\",\"id\":\"Q9UHV7\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 14\",\"id\":\"O60244\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 16\",\"id\":\"Q9Y2X0\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 17\",\"id\":\"Q9NVC6\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 1\",\"id\":\"Q15648\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 20\",\"id\":\"Q9H944\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 23\",\"id\":\"Q9ULK4\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 24\",\"id\":\"O75448\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 27\",\"id\":\"Q6P2C8\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 30\",\"id\":\"Q96HR3\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 31\",\"id\":\"Q9Y3C7\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 4\",\"id\":\"Q9NPJ6\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 6\",\"id\":\"O75586\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 7\",\"id\":\"O43513\"},{\"label\":\"Monoglyceride lipase\",\"id\":\"Q99685\"},{\"label\":\"NAD-dependent protein deacetylase sirtuin-1\",\"id\":\"Q96EB6\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Nuclear receptor coactivator 3\",\"id\":\"Q9Y6Q9\"},{\"label\":\"Nuclear receptor coactivator 4\",\"id\":\"Q13772\"},{\"label\":\"Nuclear receptor coactivator 6\",\"id\":\"Q14686\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"PAX-interacting protein 1\",\"id\":\"Q6ZW49\"},{\"label\":\"PAXIP1-associated glutamate-rich protein 1\",\"id\":\"Q9BTK6\"},{\"label\":\"Patatin-like phospholipase domain-containing protein 2\",\"id\":\"Q96AD5\"},{\"label\":\"Perilipin-1\",\"id\":\"O60240\"},{\"label\":\"Perilipin-2\",\"id\":\"Q99541\"},{\"label\":\"Perilipin-4\",\"id\":\"Q96Q06\"},{\"label\":\"Peroxisomal membrane protein 11A\",\"id\":\"O75192\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha\",\"id\":\"Q9UBK2\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-beta\",\"id\":\"Q86YN6\"},{\"label\":\"Phosphatidate phosphatase LPIN1\",\"id\":\"Q14693\"},{\"label\":\"Platelet glycoprotein 4\",\"id\":\"P16671\"},{\"label\":\"Pleckstrin homology-like domain family A member 1\",\"id\":\"Q8WV24\"},{\"label\":\"Protein dpy-30 homolog\",\"id\":\"Q9C005\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Retinoblastoma-binding protein 5\",\"id\":\"Q15291\"},{\"label\":\"Retinoic acid receptor 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective MTR causes HMAG", "protein_name": "[{\"label\":\"Methionine synthase reductase\",\"id\":\"Q9UBK8\"},{\"label\":\"Methionine synthase\",\"id\":\"Q99707\"}]", "uniprot_id": "[\"Q99707\",\"Q9UBK8\"]", "gene_symbol": "[\"MTR\",\"MTRR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cilium Assembly", "protein_name": "[{\"label\":\"Alpha-tubulin N-acetyltransferase 1\",\"id\":\"Q5SQI0\"},{\"label\":\"Histone deacetylase 6\",\"id\":\"Q9UBN7\"}]", "uniprot_id": "[\"Q5SQI0\",\"Q9UBN7\"]", "gene_symbol": "[\"ATAT1\",\"C6orf134\",\"HDAC6\",\"KIAA0901\",\"MEC17\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "STAT6-mediated induction of chemokines", "protein_name": "[{\"label\":\"Serine/threonine-protein kinase TBK1\",\"id\":\"Q9UHD2\"},{\"label\":\"Signal transducer and activator of transcription 6\",\"id\":\"P42226\"},{\"label\":\"Stimulator of interferon genes protein\",\"id\":\"Q86WV6\"}]", "uniprot_id": "[\"P42226\",\"Q86WV6\",\"Q9UHD2\"]", 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"gtc_id": "[\"\"]" }, { "pathway_label": "Late endosomal microautophagy", "protein_name": "[{\"label\":\"ADP-ribosylation factor-like protein 13B\",\"id\":\"Q3SXY8\"},{\"label\":\"Centrin-1\",\"id\":\"Q12798\"},{\"label\":\"Charged multivesicular body protein 2a\",\"id\":\"O43633\"},{\"label\":\"Charged multivesicular body protein 2b\",\"id\":\"Q9UQN3\"},{\"label\":\"Charged multivesicular body protein 3\",\"id\":\"Q9Y3E7\"},{\"label\":\"Charged multivesicular body protein 4a\",\"id\":\"Q9BY43\"},{\"label\":\"Charged multivesicular body protein 4b\",\"id\":\"Q9H444\"},{\"label\":\"Charged multivesicular body protein 4c\",\"id\":\"Q96CF2\"},{\"label\":\"Charged multivesicular body protein 6\",\"id\":\"Q96FZ7\"},{\"label\":\"Charged multivesicular body protein 7\",\"id\":\"Q8WUX9\"},{\"label\":\"Cystic fibrosis transmembrane conductance regulator\",\"id\":\"P13569\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Hemoglobin subunit 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protein 28 homolog\",\"id\":\"Q9UK41\"},{\"label\":\"Vacuolar protein sorting-associated protein 37A\",\"id\":\"Q8NEZ2\"},{\"label\":\"Vacuolar protein sorting-associated protein 37B\",\"id\":\"Q9H9H4\"},{\"label\":\"Vacuolar protein sorting-associated protein 37C\",\"id\":\"A5D8V6\"},{\"label\":\"Vacuolar protein sorting-associated protein 37D\",\"id\":\"Q86XT2\"}]", "uniprot_id": "[\"A5D8V6\",\"O43633\",\"O60664\",\"O95613\",\"P07998\",\"P0CG47\",\"P0CG48\",\"P11142\",\"P13569\",\"P62979\",\"P62987\",\"P68871\",\"Q12798\",\"Q13099\",\"Q3SXY8\",\"Q86XT2\",\"Q8NEZ2\",\"Q8WUX9\",\"Q96CF2\",\"Q96EY5\",\"Q96FZ7\",\"Q99497\",\"Q99541\",\"Q99816\",\"Q9BY43\",\"Q9H444\",\"Q9H7P6\",\"Q9H9H4\",\"Q9NZ09\",\"Q9UBN7\",\"Q9UK41\",\"Q9UQN3\",\"Q9Y3E7\"]", "gene_symbol": 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subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Fibroblast growth factor 11\",\"id\":\"Q92914\"},{\"label\":\"Fibroblast growth factor 12\",\"id\":\"P61328\"},{\"label\":\"Fibroblast growth factor 13\",\"id\":\"Q92913\"},{\"label\":\"Fibroblast growth factor 14\",\"id\":\"Q92915\"},{\"label\":\"Ran guanine nucleotide release factor\",\"id\":\"Q9HD47\"},{\"label\":\"Sodium channel protein type 1 subunit alpha\",\"id\":\"P35498\"},{\"label\":\"Sodium channel protein type 10 subunit alpha\",\"id\":\"Q9Y5Y9\"},{\"label\":\"Sodium channel protein type 11 subunit alpha\",\"id\":\"Q9UI33\"},{\"label\":\"Sodium channel protein type 2 subunit alpha\",\"id\":\"Q99250\"},{\"label\":\"Sodium channel protein type 3 subunit alpha\",\"id\":\"Q9NY46\"},{\"label\":\"Sodium channel protein type 4 subunit alpha\",\"id\":\"P35499\"},{\"label\":\"Sodium channel protein type 5 subunit alpha\",\"id\":\"Q14524\"},{\"label\":\"Sodium channel protein type 7 subunit alpha\",\"id\":\"Q01118\"},{\"label\":\"Sodium channel protein type 8 subunit alpha\",\"id\":\"Q9UQD0\"},{\"label\":\"Sodium channel protein type 9 subunit alpha\",\"id\":\"Q15858\"},{\"label\":\"Sodium channel regulatory subunit beta-1\",\"id\":\"Q07699\"},{\"label\":\"Sodium channel regulatory subunit beta-2\",\"id\":\"O60939\"},{\"label\":\"Sodium channel regulatory subunit beta-3\",\"id\":\"Q9NY72\"},{\"label\":\"Sodium channel subunit beta-4\",\"id\":\"Q8IWT1\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit alpha-1C\",\"id\":\"Q13936\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-1\",\"id\":\"Q02641\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-2\",\"id\":\"Q08289\"},{\"label\":\"Voltage-dependent calcium channel gamma-4 subunit\",\"id\":\"Q9UBN1\"},{\"label\":\"Voltage-dependent calcium channel gamma-6 subunit\",\"id\":\"Q9BXT2\"},{\"label\":\"Voltage-dependent calcium channel gamma-7 subunit\",\"id\":\"P62955\"},{\"label\":\"Voltage-dependent calcium channel gamma-8 subunit\",\"id\":\"Q8WXS5\"},{\"label\":\"Voltage-dependent calcium channel subunit alpha-2/delta-2\",\"id\":\"Q9NY47\"}]", "uniprot_id": "[\"O60939\",\"P0DP23\",\"P35498\",\"P35499\",\"P61328\",\"P62955\",\"Q01118\",\"Q02641\",\"Q07699\",\"Q08289\",\"Q13554\",\"Q13555\",\"Q13557\",\"Q13936\",\"Q14524\",\"Q15858\",\"Q8IWT1\",\"Q8WXS5\",\"Q92913\",\"Q92914\",\"Q92915\",\"Q99250\",\"Q9BXT2\",\"Q9HD47\",\"Q9NY46\",\"Q9NY47\",\"Q9NY72\",\"Q9UBN1\",\"Q9UI33\",\"Q9UQD0\",\"Q9UQM7\",\"Q9Y5Y9\"]", "gene_symbol": 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7\",\"id\":\"Q13164\"}]", "uniprot_id": "[\"Q13163\",\"Q13164\"]", "gene_symbol": "[\"BMK1\",\"ERK5\",\"MAP2K5\",\"MAPK7\",\"MEK5\",\"MKK5\",\"PRKM7\",\"PRKMK5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HS-GAG biosynthesis", "protein_name": "[{\"label\":\"Agrin\",\"id\":\"O00468\"},{\"label\":\"Basement membrane-specific heparan sulfate proteoglycan core protein\",\"id\":\"P98160\"},{\"label\":\"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1\",\"id\":\"P52848\"},{\"label\":\"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2\",\"id\":\"P52849\"},{\"label\":\"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3\",\"id\":\"O95803\"},{\"label\":\"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4\",\"id\":\"Q9H3R1\"},{\"label\":\"D-glucuronyl C5-epimerase\",\"id\":\"O94923\"},{\"label\":\"Exostosin-1\",\"id\":\"Q16394\"},{\"label\":\"Exostosin-2\",\"id\":\"Q93063\"},{\"label\":\"Glypican-1\",\"id\":\"P35052\"},{\"label\":\"Glypican-2\",\"id\":\"Q8N158\"},{\"label\":\"Glypican-3\",\"id\":\"P51654\"},{\"label\":\"Glypican-4\",\"id\":\"O75487\"},{\"label\":\"Glypican-5\",\"id\":\"P78333\"},{\"label\":\"Glypican-6\",\"id\":\"Q9Y625\"},{\"label\":\"Heparan sulfate 2-O-sulfotransferase 1\",\"id\":\"Q7LGA3\"},{\"label\":\"Heparan sulfate glucosamine 3-O-sulfotransferase 1\",\"id\":\"O14792\"},{\"label\":\"Heparan sulfate glucosamine 3-O-sulfotransferase 2\",\"id\":\"Q9Y278\"},{\"label\":\"Heparan sulfate glucosamine 3-O-sulfotransferase 3A1\",\"id\":\"Q9Y663\"},{\"label\":\"Heparan sulfate glucosamine 3-O-sulfotransferase 3B1\",\"id\":\"Q9Y662\"},{\"label\":\"Heparan sulfate glucosamine 3-O-sulfotransferase 4\",\"id\":\"Q9Y661\"},{\"label\":\"Heparan sulfate glucosamine 3-O-sulfotransferase 5\",\"id\":\"Q8IZT8\"},{\"label\":\"Heparan sulfate glucosamine 3-O-sulfotransferase 6\",\"id\":\"Q96QI5\"},{\"label\":\"Heparan-sulfate 6-O-sulfotransferase 1\",\"id\":\"O60243\"},{\"label\":\"Heparan-sulfate 6-O-sulfotransferase 2\",\"id\":\"Q96MM7\"},{\"label\":\"Heparan-sulfate 6-O-sulfotransferase 3\",\"id\":\"Q8IZP7\"},{\"label\":\"Nucleotide sugar transporter SLC35D2\",\"id\":\"Q76EJ3\"},{\"label\":\"Syndecan-1\",\"id\":\"P18827\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Syndecan-3\",\"id\":\"O75056\"},{\"label\":\"Syndecan-4\",\"id\":\"P31431\"}]", "uniprot_id": "[\"O00468\",\"O14792\",\"O60243\",\"O75056\",\"O75487\",\"O94923\",\"O95803\",\"P18827\",\"P31431\",\"P34741\",\"P35052\",\"P51654\",\"P52848\",\"P52849\",\"P78333\",\"P98160\",\"Q16394\",\"Q76EJ3\",\"Q7LGA3\",\"Q8IZP7\",\"Q8IZT8\",\"Q8N158\",\"Q93063\",\"Q96MM7\",\"Q96QI5\",\"Q9H3R1\",\"Q9Y278\",\"Q9Y625\",\"Q9Y661\",\"Q9Y662\",\"Q9Y663\"]", "gene_symbol": 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cell adhesion molecule\",\"id\":\"P16284\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase Yes\",\"id\":\"P07947\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"}]", "uniprot_id": "[\"P05106\",\"P06239\",\"P06241\",\"P06756\",\"P07947\",\"P07948\",\"P16284\",\"P19174\",\"P29350\",\"Q06124\",\"Q92835\"]", "gene_symbol": "[\"FYN\",\"GP3A\",\"HCP\",\"INPP5D\",\"ITGAV\",\"ITGB3\",\"JTK8\",\"LCK\",\"LYN\",\"MSK8\",\"PECAM1\",\"PLC1\",\"PLCG1\",\"PTP1C\",\"PTP2C\",\"PTPN11\",\"PTPN6\",\"SHIP\",\"SHIP1\",\"SHPTP2\",\"VNRA\",\"VTNR\",\"YES\",\"YES1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Phosphate bond hydrolysis by NTPDase proteins", "protein_name": "[{\"label\":\"Ectonucleoside triphosphate diphosphohydrolase 1\",\"id\":\"P49961\"},{\"label\":\"Ectonucleoside triphosphate diphosphohydrolase 2\",\"id\":\"Q9Y5L3\"},{\"label\":\"Ectonucleoside triphosphate diphosphohydrolase 3\",\"id\":\"O75355\"},{\"label\":\"Ectonucleoside triphosphate diphosphohydrolase 4\",\"id\":\"Q9Y227\"},{\"label\":\"Ectonucleoside triphosphate diphosphohydrolase 6\",\"id\":\"O75354\"},{\"label\":\"Ectonucleoside triphosphate diphosphohydrolase 7\",\"id\":\"Q9NQZ7\"},{\"label\":\"Ectonucleoside triphosphate diphosphohydrolase 8\",\"id\":\"Q5MY95\"},{\"label\":\"Nucleoside diphosphate phosphatase ENTPD5\",\"id\":\"O75356\"}]", "uniprot_id": "[\"O75354\",\"O75355\",\"O75356\",\"P49961\",\"Q5MY95\",\"Q9NQZ7\",\"Q9Y227\",\"Q9Y5L3\"]", "gene_symbol": "[\"CD39\",\"CD39L1\",\"CD39L2\",\"CD39L3\",\"CD39L4\",\"ENTPD1\",\"ENTPD2\",\"ENTPD3\",\"ENTPD4\",\"ENTPD5\",\"ENTPD6\",\"ENTPD7\",\"ENTPD8\",\"IL6ST2\",\"KIAA0392\",\"LALP1\",\"LALP70\",\"LYSAL1\",\"PCPH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX3 regulates CDKN1A transcription", "protein_name": "[{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Mothers against decapentaplegic homolog 3\",\"id\":\"P84022\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"Runt-related transcription factor 3\",\"id\":\"Q13761\"},{\"label\":\"Transforming growth factor beta-1 proprotein\",\"id\":\"P01137\"},{\"label\":\"Zinc finger homeobox protein 3\",\"id\":\"Q15911\"}]", "uniprot_id": "[\"P01137\",\"P04637\",\"P38936\",\"P84022\",\"Q13485\",\"Q13761\",\"Q15911\"]", "gene_symbol": "[\"AML2\",\"ATBF1\",\"C16orf47\",\"CAP20\",\"CBFA3\",\"CDKN1\",\"CDKN1A\",\"CIP1\",\"DPC4\",\"MADH3\",\"MADH4\",\"MDA6\",\"P53\",\"PEBP2A3\",\"PIC1\",\"RUNX3\",\"SDI1\",\"SMAD3\",\"SMAD4\",\"TGFB\",\"TGFB1\",\"TP53\",\"WAF1\",\"ZFHX3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nuclear import of Rev protein", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"GTP-binding nuclear protein Ran\",\"id\":\"P62826\"},{\"label\":\"Importin subunit beta-1\",\"id\":\"Q14974\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleophosmin\",\"id\":\"P06748\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Regulator of chromosome condensation\",\"id\":\"P18754\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": 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11\",\"id\":\"Q15759\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Mitogen-activated protein kinase 8\",\"id\":\"P45983\"},{\"label\":\"Mitogen-activated protein kinase 9\",\"id\":\"P45984\"},{\"label\":\"Protein c-Fos\",\"id\":\"P01100\"},{\"label\":\"Transcription factor Jun\",\"id\":\"P05412\"}]", "uniprot_id": "[\"P01100\",\"P05412\",\"P15336\",\"P27361\",\"P28482\",\"P45983\",\"P45984\",\"P53779\",\"Q15759\",\"Q16539\"]", "gene_symbol": 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protein of 70 kDa\",\"id\":\"Q8NHQ1\"},{\"label\":\"Centrosomal protein of 72 kDa\",\"id\":\"Q9P209\"},{\"label\":\"Centrosomal protein of 76 kDa\",\"id\":\"Q8TAP6\"},{\"label\":\"Centrosomal protein of 78 kDa\",\"id\":\"Q5JTW2\"},{\"label\":\"Centrosome-associated protein ALMS1\",\"id\":\"Q8TCU4\"},{\"label\":\"Centrosome-associated protein CEP250\",\"id\":\"Q9BV73\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoskeleton-associated protein 5\",\"id\":\"Q14008\"},{\"label\":\"Dynactin subunit 2\",\"id\":\"Q13561\"},{\"label\":\"Dynactin subunit 3\",\"id\":\"O75935\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"HAUS augmin-like complex subunit 1\",\"id\":\"Q96CS2\"},{\"label\":\"HAUS augmin-like complex subunit 2\",\"id\":\"Q9NVX0\"},{\"label\":\"HAUS augmin-like complex 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"gtc_id": "[\"\"]" }, { "pathway_label": "Localization of the PINCH-ILK-PARVIN complex to focal adhesions", "protein_name": "[{\"label\":\"Alpha-parvin\",\"id\":\"Q9NVD7\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin-linked protein kinase\",\"id\":\"Q13418\"},{\"label\":\"Paxillin\",\"id\":\"P49023\"}]", "uniprot_id": "[\"P05556\",\"P49023\",\"Q13418\",\"Q9NVD7\"]", "gene_symbol": "[\"FNRB\",\"ILK\",\"ILK1\",\"ILK2\",\"ITGB1\",\"MDF2\",\"MSK12\",\"MXRA2\",\"PARVA\",\"PXN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "LXRs regulate gene expression to control bile acid homeostasis", "protein_name": "[{\"label\":\"Gastrotropin\",\"id\":\"P51161\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Oxysterols receptor LXR-alpha\",\"id\":\"Q13133\"},{\"label\":\"Oxysterols receptor LXR-beta\",\"id\":\"P55055\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Retinoic acid receptor RXR-beta\",\"id\":\"P28702\"},{\"label\":\"UDP-glucuronosyltransferase 1A3\",\"id\":\"P35503\"}]", "uniprot_id": "[\"O75376\",\"P19793\",\"P28702\",\"P35503\",\"P51161\",\"P55055\",\"Q13133\",\"Q15788\",\"Q9Y618\"]", "gene_symbol": "[\"BHLHE74\",\"CTG26\",\"FABP6\",\"GNT1\",\"ILBP\",\"ILLBP\",\"KIAA1047\",\"LXRA\",\"LXRB\",\"NCOA1\",\"NCOR1\",\"NCOR2\",\"NER\",\"NR1H2\",\"NR1H3\",\"NR2B1\",\"NR2B2\",\"RXRA\",\"RXRB\",\"SRC1\",\"UGT1\",\"UGT1A3\",\"UNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HDR through MMEJ (alt-NHEJ)", "protein_name": "[{\"label\":\"Breast cancer type 2 susceptibility protein\",\"id\":\"P51587\"},{\"label\":\"DNA endonuclease RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA ligase 3\",\"id\":\"P49916\"},{\"label\":\"DNA polymerase theta\",\"id\":\"O75417\"},{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA repair protein RAD52 homolog\",\"id\":\"P43351\"},{\"label\":\"DNA repair protein XRCC1\",\"id\":\"P18887\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Flap endonuclease 1\",\"id\":\"P39748\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"Poly [ADP-ribose] polymerase 1\",\"id\":\"P09874\"},{\"label\":\"Poly [ADP-ribose] polymerase 2\",\"id\":\"Q9UGN5\"}]", "uniprot_id": "[\"O60934\",\"O75417\",\"P09874\",\"P18887\",\"P39748\",\"P43351\",\"P49916\",\"P49959\",\"P51587\",\"Q92878\",\"Q99708\",\"Q9UGN5\"]", "gene_symbol": "[\"ADPRT\",\"ADPRT2\",\"ADPRTL2\",\"BRCA2\",\"CTIP\",\"FACD\",\"FANCD1\",\"FEN1\",\"HNGS1\",\"LIG3\",\"MRE11\",\"MRE11A\",\"NBN\",\"NBS\",\"NBS1\",\"P95\",\"PARP1\",\"PARP2\",\"POLH\",\"POLQ\",\"PPOL\",\"RAD2\",\"RAD50\",\"RAD52\",\"RBBP8\",\"XRCC1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"14-3-3 protein eta\",\"id\":\"Q04917\"},{\"label\":\"14-3-3 protein gamma\",\"id\":\"P61981\"},{\"label\":\"14-3-3 protein sigma\",\"id\":\"P31947\"},{\"label\":\"14-3-3 protein theta\",\"id\":\"P27348\"},{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"3-phosphoinositide-dependent protein kinase 1\",\"id\":\"O15530\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Membrane protein\",\"id\":\"P0DTC5\"},{\"label\":\"Nucleoprotein\",\"id\":\"P0DTC9\"},{\"label\":\"ORF3a protein\",\"id\":\"P0DTC3\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"}]", "uniprot_id": "[\"O15530\",\"P0DTC3\",\"P0DTC5\",\"P0DTC9\",\"P27348\",\"P31749\",\"P31751\",\"P31946\",\"P31947\",\"P61981\",\"P62258\",\"P63104\",\"Q03135\",\"Q04917\",\"Q9Y243\"]", "gene_symbol": "[\"3a\",\"AKT1\",\"AKT2\",\"AKT3\",\"CAV\",\"CAV1\",\"HME1\",\"M\",\"N\",\"PDK1\",\"PDPK1\",\"PKB\",\"PKBG\",\"RAC\",\"SFN\",\"YWHA1\",\"YWHAB\",\"YWHAE\",\"YWHAG\",\"YWHAH\",\"YWHAQ\",\"YWHAZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of cortical dendrite branching", "protein_name": "[{\"label\":\"Cytoplasmic protein NCK2\",\"id\":\"O43639\"},{\"label\":\"Roundabout homolog 1\",\"id\":\"Q9Y6N7\"},{\"label\":\"Roundabout homolog 2\",\"id\":\"Q9HCK4\"},{\"label\":\"Slit homolog 1 protein\",\"id\":\"O75093\"}]", "uniprot_id": "[\"O43639\",\"O75093\",\"Q9HCK4\",\"Q9Y6N7\"]", "gene_symbol": "[\"DUTT1\",\"GRB4\",\"KIAA0813\",\"KIAA1568\",\"MEGF4\",\"NCK2\",\"ROBO1\",\"ROBO2\",\"SLIL1\",\"SLIT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX1 regulates transcription of genes involved in interleukin signaling", "protein_name": "[{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"ETS-related transcription factor Elf-1\",\"id\":\"P32519\"},{\"label\":\"Interleukin-3\",\"id\":\"P08700\"},{\"label\":\"Leukemia inhibitory factor receptor\",\"id\":\"P42702\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"}]", "uniprot_id": "[\"P08700\",\"P32519\",\"P42702\",\"Q01196\",\"Q13951\"]", "gene_symbol": "[\"AML1\",\"CBFA2\",\"CBFB\",\"ELF1\",\"IL3\",\"LIFR\",\"RUNX1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Hormone ligand-binding receptors", "protein_name": "[{\"label\":\"Follicle-stimulating hormone receptor\",\"id\":\"P23945\"},{\"label\":\"Follitropin subunit beta\",\"id\":\"P01225\"},{\"label\":\"Glycoprotein hormone alpha-2\",\"id\":\"Q96T91\"},{\"label\":\"Glycoprotein hormone beta-5\",\"id\":\"Q86YW7\"},{\"label\":\"Glycoprotein hormones alpha chain\",\"id\":\"P01215\"},{\"label\":\"Gonadotropin-releasing hormone receptor\",\"id\":\"P30968\"},{\"label\":\"Lutropin subunit beta\",\"id\":\"P01229\"},{\"label\":\"Lutropin-choriogonadotropic hormone receptor\",\"id\":\"P22888\"},{\"label\":\"Progonadoliberin-1\",\"id\":\"P01148\"},{\"label\":\"Progonadoliberin-2\",\"id\":\"O43555\"},{\"label\":\"Putative gonadotropin-releasing hormone II receptor\",\"id\":\"Q96P88\"},{\"label\":\"Thyrotropin receptor\",\"id\":\"P16473\"},{\"label\":\"Thyrotropin subunit beta\",\"id\":\"P01222\"}]", "uniprot_id": "[\"O43555\",\"P01148\",\"P01215\",\"P01222\",\"P01225\",\"P01229\",\"P16473\",\"P22888\",\"P23945\",\"P30968\",\"Q86YW7\",\"Q96P88\",\"Q96T91\"]", "gene_symbol": "[\"CGA\",\"FSHB\",\"FSHR\",\"GNRH\",\"GNRH1\",\"GNRH2\",\"GNRHR\",\"GNRHR2\",\"GPA2\",\"GPB5\",\"GPHA2\",\"GPHB5\",\"GRH\",\"GRHR\",\"LCGR\",\"LGR1\",\"LGR2\",\"LGR3\",\"LHB\",\"LHCGR\",\"LHRH\",\"LHRHR\",\"TSHB\",\"TSHR\",\"ZLUT1\",\"ZSIG51\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "GABA synthesis, release, reuptake and degradation", "protein_name": "[{\"label\":\"Complexin-1\",\"id\":\"O14810\"},{\"label\":\"DnaJ homolog subfamily C member 5\",\"id\":\"Q9H3Z4\"},{\"label\":\"Glutamate decarboxylase 1\",\"id\":\"Q99259\"},{\"label\":\"Glutamate decarboxylase 2\",\"id\":\"Q05329\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Ras-related protein Rab-3A\",\"id\":\"P20336\"},{\"label\":\"Regulating synaptic membrane exocytosis protein 1\",\"id\":\"Q86UR5\"},{\"label\":\"Synaptosomal-associated protein 25\",\"id\":\"P60880\"},{\"label\":\"Synaptotagmin-1\",\"id\":\"P21579\"},{\"label\":\"Syntaxin-1A\",\"id\":\"Q16623\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"},{\"label\":\"Vesicular inhibitory amino acid transporter\",\"id\":\"Q9H598\"}]", "uniprot_id": "[\"O14810\",\"P11142\",\"P20336\",\"P21579\",\"P60880\",\"P63027\",\"Q05329\",\"Q16623\",\"Q86UR5\",\"Q99259\",\"Q9H3Z4\",\"Q9H598\"]", "gene_symbol": 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repair endonuclease PMS2\",\"id\":\"P54278\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"}]", "uniprot_id": "[\"P12004\",\"P15927\",\"P18858\",\"P20585\",\"P27694\",\"P28340\",\"P35244\",\"P40692\",\"P43246\",\"P49005\",\"P54278\",\"Q15054\",\"Q9HCU8\",\"Q9UQ84\"]", "gene_symbol": "[\"COCA2\",\"DUC1\",\"DUG\",\"EXO1\",\"EXOI\",\"HEX1\",\"KIAA0039\",\"LIG1\",\"MLH1\",\"MSH2\",\"MSH3\",\"PCNA\",\"PMS2\",\"PMSL2\",\"POLD\",\"POLD1\",\"POLD2\",\"POLD3\",\"POLD4\",\"POLDS\",\"REPA1\",\"REPA2\",\"REPA3\",\"RPA1\",\"RPA14\",\"RPA2\",\"RPA3\",\"RPA32\",\"RPA34\",\"RPA70\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by ERBB2", "protein_name": "[{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase 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2\",\"id\":\"Q9H160\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1\",\"id\":\"Q13526\"},{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha\",\"id\":\"P48426\"},{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 beta\",\"id\":\"P78356\"},{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma\",\"id\":\"Q8TBX8\"},{\"label\":\"Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase\",\"id\":\"Q86T03\"}]", "uniprot_id": "[\"P04637\",\"P48426\",\"P52564\",\"P78356\",\"Q09472\",\"Q13526\",\"Q86T03\",\"Q8TBX8\",\"Q9H160\"]", "gene_symbol": "[\"C14orf9\",\"EP300\",\"ING1L\",\"ING2\",\"MAP2K6\",\"MEK6\",\"MKK6\",\"P300\",\"P53\",\"PI5P4KA\",\"PIN1\",\"PIP4K2A\",\"PIP4K2B\",\"PIP4K2C\",\"PIP4P1\",\"PIP5K2\",\"PIP5K2A\",\"PIP5K2B\",\"PIP5K2C\",\"PRKMK6\",\"SKK3\",\"TMEM55B\",\"TP53\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Impaired BRCA2 binding to PALB2", "protein_name": "[{\"label\":\"BRCA1-associated RING domain protein 1\",\"id\":\"Q99728\"},{\"label\":\"Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN\",\"id\":\"Q14191\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"},{\"label\":\"Breast cancer type 2 susceptibility protein\",\"id\":\"P51587\"},{\"label\":\"DNA endonuclease RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA repair protein RAD51 homolog 1\",\"id\":\"Q06609\"},{\"label\":\"DNA repair protein RAD51 homolog 2\",\"id\":\"O15315\"},{\"label\":\"DNA repair protein RAD51 homolog 3\",\"id\":\"O43502\"},{\"label\":\"DNA repair protein RAD51 homolog 4\",\"id\":\"O75771\"},{\"label\":\"DNA repair protein XRCC2\",\"id\":\"O43543\"},{\"label\":\"DNA replication ATP-dependent helicase/nuclease DNA2\",\"id\":\"P51530\"},{\"label\":\"DNA topoisomerase 3-alpha\",\"id\":\"Q13472\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Exonuclease 1\",\"id\":\"Q9UQ84\"},{\"label\":\"Fanconi anemia group J protein\",\"id\":\"Q9BX63\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"Partner and localizer of BRCA2\",\"id\":\"Q86YC2\"},{\"label\":\"RAD51-associated protein 1\",\"id\":\"Q96B01\"},{\"label\":\"RecQ-like DNA helicase BLM\",\"id\":\"P54132\"},{\"label\":\"RecQ-mediated genome instability protein 1\",\"id\":\"Q9H9A7\"},{\"label\":\"RecQ-mediated genome instability protein 2\",\"id\":\"Q96E14\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"}]", "uniprot_id": "[\"O15315\",\"O43502\",\"O43543\",\"O60934\",\"O75771\",\"P38398\",\"P49959\",\"P51530\",\"P51587\",\"P54132\",\"Q06609\",\"Q13315\",\"Q13472\",\"Q14191\",\"Q86YC2\",\"Q92878\",\"Q92993\",\"Q96B01\",\"Q96E14\",\"Q99708\",\"Q99728\",\"Q9BX63\",\"Q9H9A7\",\"Q9UQ84\"]", "gene_symbol": 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protein\",\"id\":\"O43323\"},{\"label\":\"Indian hedgehog protein\",\"id\":\"Q14623\"},{\"label\":\"Protein-cysteine N-palmitoyltransferase HHAT\",\"id\":\"Q5VTY9\"},{\"label\":\"Sonic hedgehog protein\",\"id\":\"Q15465\"}]", "uniprot_id": "[\"O43323\",\"Q14623\",\"Q15465\",\"Q5VTY9\"]", "gene_symbol": "[\"DHH\",\"HHAT\",\"IHH\",\"MART2\",\"SHH\",\"SKI1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CD209 (DC-SIGN) signaling", "protein_name": "[{\"label\":\"CD209 antigen\",\"id\":\"Q9NNX6\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Intercellular adhesion molecule 2\",\"id\":\"P13598\"},{\"label\":\"Intercellular adhesion molecule 3\",\"id\":\"P32942\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"Ribosomal protein S6 kinase alpha-5\",\"id\":\"O75582\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"Transcription factor RelB\",\"id\":\"Q01201\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": 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"[\"ALK5\",\"FKBP1\",\"FKBP12\",\"FKBP1A\",\"SKR4\",\"TGFB\",\"TGFB1\",\"TGFBR1\",\"TGFBR2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective Base Excision Repair Associated with NEIL3", "protein_name": "[{\"label\":\"Endonuclease 8-like 3\",\"id\":\"Q8TAT5\"}]", "uniprot_id": "[\"Q8TAT5\"]", "gene_symbol": "[\"NEIL3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization", "protein_name": "[{\"label\":\"ADP/ATP translocase 1\",\"id\":\"P12235\"},{\"label\":\"ADP/ATP translocase 2\",\"id\":\"P05141\"},{\"label\":\"ADP/ATP translocase 3\",\"id\":\"P12236\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"}]", "uniprot_id": "[\"P05141\",\"P12235\",\"P12236\",\"P69726\"]", "gene_symbol": "[\"AAC1\",\"AAC2\",\"AAC3\",\"ANT1\",\"ANT2\",\"ANT3\",\"SLC25A4\",\"SLC25A5\",\"SLC25A6\",\"vpr\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-37 signaling", "protein_name": 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20\",\"id\":\"Q4JDL3\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 23\",\"id\":\"Q9H3S7\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 2\",\"id\":\"P17706\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 4\",\"id\":\"P29074\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 5\",\"id\":\"P54829\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 7\",\"id\":\"P35236\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 9\",\"id\":\"P43378\"}]", "uniprot_id": "[\"O95998\",\"P17706\",\"P29074\",\"P29350\",\"P29466\",\"P35236\",\"P40763\",\"P43378\",\"P54829\",\"P84022\",\"Q05209\",\"Q06124\",\"Q12923\",\"Q13478\",\"Q15678\",\"Q4JDL3\",\"Q6IA17\",\"Q99952\",\"Q9H3S7\",\"Q9NZH6\",\"Q9UHD2\"]", "gene_symbol": 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"[\"DNC\",\"MUP1\",\"SLC19A2\",\"SLC19A3\",\"SLC25A19\",\"THT1\",\"THTPA\",\"TPK1\",\"TRMA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of RAC1", "protein_name": "[{\"label\":\"Cytoplasmic protein NCK2\",\"id\":\"O43639\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Roundabout homolog 1\",\"id\":\"Q9Y6N7\"},{\"label\":\"SH2/SH3 adapter protein NCK1\",\"id\":\"P16333\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"Serine/threonine-protein kinase PAK 4\",\"id\":\"O96013\"},{\"label\":\"Serine/threonine-protein kinase PAK 5\",\"id\":\"Q9P286\"},{\"label\":\"Serine/threonine-protein kinase PAK 6\",\"id\":\"Q9NQU5\"},{\"label\":\"Slit homolog 2 protein\",\"id\":\"O94813\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Son of sevenless homolog 2\",\"id\":\"Q07890\"}]", "uniprot_id": "[\"O43639\",\"O75914\",\"O94813\",\"O96013\",\"P16333\",\"P63000\",\"Q07889\",\"Q07890\",\"Q13153\",\"Q13177\",\"Q9NQU5\",\"Q9P286\",\"Q9Y6N7\"]", "gene_symbol": "[\"DUTT1\",\"GRB4\",\"KIAA1142\",\"KIAA1264\",\"NCK\",\"NCK1\",\"NCK2\",\"OPHN3\",\"PAK1\",\"PAK2\",\"PAK3\",\"PAK4\",\"PAK5\",\"PAK6\",\"PAK7\",\"RAC1\",\"ROBO1\",\"SLIL3\",\"SLIT2\",\"SOS1\",\"SOS2\",\"TC25\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Reelin signalling pathway", "protein_name": "[{\"label\":\"Disabled homolog 1\",\"id\":\"O75553\"},{\"label\":\"Reelin\",\"id\":\"P78509\"},{\"label\":\"SH3 domain-containing kinase-binding protein 1\",\"id\":\"Q96B97\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Very low-density lipoprotein receptor\",\"id\":\"P98155\"}]", "uniprot_id": "[\"O75553\",\"P06241\",\"P78509\",\"P98155\",\"Q96B97\"]", "gene_symbol": "[\"CIN85\",\"DAB1\",\"FYN\",\"RELN\",\"SH3KBP1\",\"VLDLR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TP53 Regulates Transcription of DNA Repair Genes", "protein_name": "[{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"},{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-2\",\"id\":\"P15336\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-K\",\"id\":\"O75909\"},{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-T2\",\"id\":\"O60583\"},{\"label\":\"Cyclin-dependent kinase 12\",\"id\":\"Q9NYV4\"},{\"label\":\"Cyclin-dependent kinase 13\",\"id\":\"Q14004\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"DNA damage-binding protein 2\",\"id\":\"Q92466\"},{\"label\":\"DNA mismatch repair protein Mlh1\",\"id\":\"P40692\"},{\"label\":\"DNA mismatch repair protein 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3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 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"gtc_id": "[\"\"]" }, { "pathway_label": "HDL assembly", "protein_name": "[{\"label\":\"Alpha-2-macroglobulin\",\"id\":\"P01023\"},{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Palmitoyltransferase ZDHHC8\",\"id\":\"Q9ULC8\"},{\"label\":\"Phospholipid-transporting ATPase ABCA1\",\"id\":\"O95477\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": "[\"O95477\",\"P01023\",\"P02647\",\"P17612\",\"P22612\",\"P22694\",\"Q9ULC8\"]", "gene_symbol": "[\"A2M\",\"ABC1\",\"ABCA1\",\"APOA1\",\"CERP\",\"CPAMD5\",\"KIAA1292\",\"PKACA\",\"PRKACA\",\"PRKACB\",\"PRKACG\",\"ZDHHC8\",\"ZDHHCL1\",\"ZNF378\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of pyruvate metabolism", "protein_name": "[{\"label\":\"Armadillo repeat-containing protein 8\",\"id\":\"Q8IUR7\"},{\"label\":\"E3 ubiquitin-protein transferase MAEA\",\"id\":\"Q7L5Y9\"},{\"label\":\"E3 ubiquitin-protein transferase RMND5A\",\"id\":\"Q9H871\"},{\"label\":\"E3 ubiquitin-protein transferase RMND5B\",\"id\":\"Q96G75\"},{\"label\":\"Glucose-induced degradation protein 4 homolog\",\"id\":\"Q8IVV7\"},{\"label\":\"Glucose-induced degradation protein 8 homolog\",\"id\":\"Q9NWU2\"},{\"label\":\"L-lactate dehydrogenase A chain\",\"id\":\"P00338\"},{\"label\":\"Muskelin\",\"id\":\"Q9UL63\"},{\"label\":\"NADP-dependent malic enzyme\",\"id\":\"P48163\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Ran-binding protein 9\",\"id\":\"Q96S59\"},{\"label\":\"Serine/threonine-protein kinase Nek1\",\"id\":\"Q96PY6\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"WD repeat-containing protein 26\",\"id\":\"Q9H7D7\"}]", "uniprot_id": "[\"P00338\",\"P0CG47\",\"P0CG48\",\"P48163\",\"P62979\",\"P62987\",\"Q7L5Y9\",\"Q8IUR7\",\"Q8IVV7\",\"Q96G75\",\"Q96PY6\",\"Q96S59\",\"Q9H7D7\",\"Q9H871\",\"Q9NWU2\",\"Q9UL63\"]", "gene_symbol": "[\"ARMC8\",\"C17orf39\",\"C20orf11\",\"CDW2\",\"EMP\",\"GID4\",\"GID8\",\"KIAA1901\",\"LDHA\",\"MAEA\",\"ME1\",\"MIP2\",\"MKLN1\",\"NEK1\",\"RANBP9\",\"RANBPM\",\"RMND5A\",\"RMND5B\",\"RPS27A\",\"TWA1\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"VID24\",\"WDR26\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Selenocysteine synthesis", "protein_name": "[{\"label\":\"L-seryl-tRNA(Sec) kinase\",\"id\":\"Q8IV42\"},{\"label\":\"Large ribosomal subunit protein P1\",\"id\":\"P05386\"},{\"label\":\"Large ribosomal subunit protein P2\",\"id\":\"P05387\"},{\"label\":\"Large ribosomal subunit protein eL13\",\"id\":\"P26373\"},{\"label\":\"Large ribosomal subunit protein eL14\",\"id\":\"P50914\"},{\"label\":\"Large ribosomal subunit protein eL15\",\"id\":\"P61313\"},{\"label\":\"Large ribosomal subunit protein eL18\",\"id\":\"Q07020\"},{\"label\":\"Large ribosomal subunit protein eL19\",\"id\":\"P84098\"},{\"label\":\"Large ribosomal subunit protein eL20\",\"id\":\"Q02543\"},{\"label\":\"Large ribosomal subunit protein eL21\",\"id\":\"P46778\"},{\"label\":\"Large ribosomal subunit protein eL22\",\"id\":\"P35268\"},{\"label\":\"Large ribosomal subunit protein eL24\",\"id\":\"P83731\"},{\"label\":\"Large ribosomal subunit protein eL27\",\"id\":\"P61353\"},{\"label\":\"Large ribosomal subunit protein eL28\",\"id\":\"P46779\"},{\"label\":\"Large ribosomal subunit protein eL29\",\"id\":\"P47914\"},{\"label\":\"Large ribosomal subunit protein eL30\",\"id\":\"P62888\"},{\"label\":\"Large ribosomal subunit protein eL31\",\"id\":\"P62899\"},{\"label\":\"Large ribosomal subunit protein eL32\",\"id\":\"P62910\"},{\"label\":\"Large ribosomal subunit protein eL33\",\"id\":\"P18077\"},{\"label\":\"Large ribosomal subunit protein 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ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS32\",\"id\":\"P62945\"},{\"label\":\"Small ribosomal subunit protein eS4, X isoform\",\"id\":\"P62701\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 1\",\"id\":\"P22090\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 2\",\"id\":\"Q8TD47\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein eS7\",\"id\":\"P62081\"},{\"label\":\"Small ribosomal subunit protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Platelet degranulation", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 4\",\"id\":\"O15439\"},{\"label\":\"Adenylyl cyclase-associated protein 1\",\"id\":\"Q01518\"},{\"label\":\"Albumin\",\"id\":\"P02768\"},{\"label\":\"Alpha-1-acid glycoprotein 1\",\"id\":\"P02763\"},{\"label\":\"Alpha-1-acid glycoprotein 2\",\"id\":\"P19652\"},{\"label\":\"Alpha-1-antichymotrypsin\",\"id\":\"P01011\"},{\"label\":\"Alpha-1-antitrypsin\",\"id\":\"P01009\"},{\"label\":\"Alpha-1B-glycoprotein\",\"id\":\"P04217\"},{\"label\":\"Alpha-2-HS-glycoprotein\",\"id\":\"P02765\"},{\"label\":\"Alpha-2-antiplasmin\",\"id\":\"P08697\"},{\"label\":\"Alpha-2-macroglobulin\",\"id\":\"P01023\"},{\"label\":\"Alpha-actinin-1\",\"id\":\"P12814\"},{\"label\":\"Alpha-actinin-2\",\"id\":\"P35609\"},{\"label\":\"Alpha-actinin-4\",\"id\":\"O43707\"},{\"label\":\"Amyloid beta precursor like protein 2\",\"id\":\"Q06481\"},{\"label\":\"Amyloid-beta precursor protein\",\"id\":\"P05067\"},{\"label\":\"Annexin A5\",\"id\":\"P08758\"},{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Beta-2-glycoprotein 1\",\"id\":\"P02749\"},{\"label\":\"Bromodomain and PHD finger-containing protein 3\",\"id\":\"Q9ULD4\"},{\"label\":\"CD109 antigen\",\"id\":\"Q6YHK3\"},{\"label\":\"CD63 antigen\",\"id\":\"P08962\"},{\"label\":\"CD9 antigen\",\"id\":\"P21926\"},{\"label\":\"CYFIP-related Rac1 interactor B\",\"id\":\"Q9NUQ9\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Calumenin\",\"id\":\"O43852\"},{\"label\":\"Cathepsin W\",\"id\":\"P56202\"},{\"label\":\"Chitinase domain-containing protein 1\",\"id\":\"Q9BWS9\"},{\"label\":\"Clusterin\",\"id\":\"P10909\"},{\"label\":\"Coagulation factor V\",\"id\":\"P12259\"},{\"label\":\"Coagulation factor VIII\",\"id\":\"P00451\"},{\"label\":\"Coagulation factor XIII A chain\",\"id\":\"P00488\"},{\"label\":\"Cofilin-1\",\"id\":\"P23528\"},{\"label\":\"Complement factor D\",\"id\":\"P00746\"},{\"label\":\"Endonuclease domain-containing 1 protein\",\"id\":\"O94919\"},{\"label\":\"Endoplasmic reticulum chaperone BiP\",\"id\":\"P11021\"},{\"label\":\"Extracellular matrix protein 1\",\"id\":\"Q16610\"},{\"label\":\"Fermitin family homolog 3\",\"id\":\"Q86UX7\"},{\"label\":\"Fibrinogen alpha chain\",\"id\":\"P02671\"},{\"label\":\"Fibrinogen beta chain\",\"id\":\"P02675\"},{\"label\":\"Fibrinogen gamma chain\",\"id\":\"P02679\"},{\"label\":\"Fibronectin\",\"id\":\"P02751\"},{\"label\":\"Filamin-A\",\"id\":\"P21333\"},{\"label\":\"Fructose-bisphosphate aldolase A\",\"id\":\"P04075\"},{\"label\":\"GTP-binding protein 2\",\"id\":\"Q9BX10\"},{\"label\":\"Galectin-3-binding protein\",\"id\":\"Q08380\"},{\"label\":\"Growth arrest-specific protein 6\",\"id\":\"Q14393\"},{\"label\":\"Hepatocyte growth factor\",\"id\":\"P14210\"},{\"label\":\"Histidine-rich glycoprotein\",\"id\":\"P04196\"},{\"label\":\"Hsp90 co-chaperone Cdc37-like 1\",\"id\":\"Q7L3B6\"},{\"label\":\"Immunoglobulin superfamily containing leucine-rich repeat protein\",\"id\":\"O14498\"},{\"label\":\"Insulin-like growth factor I\",\"id\":\"P05019\"},{\"label\":\"Insulin-like growth factor II\",\"id\":\"P01344\"},{\"label\":\"Integrin alpha-IIb\",\"id\":\"P08514\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Inter-alpha-trypsin inhibitor heavy chain H3\",\"id\":\"Q06033\"},{\"label\":\"Inter-alpha-trypsin inhibitor heavy chain H4\",\"id\":\"Q14624\"},{\"label\":\"Intracellular hyaluronan-binding protein 4\",\"id\":\"Q5JVS0\"},{\"label\":\"Kallistatin\",\"id\":\"P29622\"},{\"label\":\"Kininogen-1\",\"id\":\"P01042\"},{\"label\":\"LHFPL tetraspan subfamily member 2 protein\",\"id\":\"Q6ZUX7\"},{\"label\":\"Left-right determination factor 2\",\"id\":\"O00292\"},{\"label\":\"Lymphocyte antigen 6 complex locus protein G6f\",\"id\":\"Q5SQ64\"},{\"label\":\"Lysosome-associated membrane glycoprotein 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1\",\"id\":\"P22314\"},{\"label\":\"Ubiquitin-like modifier-activating enzyme 6\",\"id\":\"A0AVT1\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"A0AVT1\",\"O00762\",\"P0CG47\",\"P0CG48\",\"P15374\",\"P22314\",\"P45974\",\"P49427\",\"P49459\",\"P51668\",\"P51965\",\"P60604\",\"P61086\",\"P62253\",\"P62256\",\"P62837\",\"P62979\",\"P62987\",\"P63146\",\"P68036\",\"Q16763\",\"Q712K3\",\"Q8WVN8\",\"Q93008\",\"Q93009\",\"Q969T4\",\"Q96B02\",\"Q96BN8\",\"Q9H832\",\"Q9NPD8\"]", "gene_symbol": 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pyrophosphate phosphatase\",\"id\":\"Q9H008\"}]", "uniprot_id": "[\"Q15181\",\"Q9H008\",\"Q9H2U2\"]", "gene_symbol": "[\"IOPPP\",\"LHPP\",\"PP\",\"PPA1\",\"PPA2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Aryl hydrocarbon receptor signalling", "protein_name": "[{\"label\":\"AH receptor-interacting protein\",\"id\":\"O00170\"},{\"label\":\"Aryl hydrocarbon receptor nuclear translocator 2\",\"id\":\"Q9HBZ2\"},{\"label\":\"Aryl hydrocarbon receptor nuclear translocator\",\"id\":\"P27540\"},{\"label\":\"Aryl hydrocarbon receptor repressor\",\"id\":\"A9YTQ3\"},{\"label\":\"Aryl hydrocarbon receptor\",\"id\":\"P35869\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Prostaglandin E synthase 3\",\"id\":\"Q15185\"}]", "uniprot_id": "[\"A9YTQ3\",\"O00170\",\"P08238\",\"P27540\",\"P35869\",\"Q15185\",\"Q9HBZ2\"]", "gene_symbol": "[\"AHR\",\"AHRR\",\"AIP\",\"ARNT\",\"ARNT2\",\"BHLHE1\",\"BHLHE2\",\"BHLHE76\",\"BHLHE77\",\"HSP90AB1\",\"HSP90B\",\"HSPC2\",\"HSPC3\",\"HSPCB\",\"KIAA0307\",\"KIAA1234\",\"P23\",\"PTGES3\",\"TEBP\",\"XAP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Modulation by Mtb of host immune system", "protein_name": "[{\"label\":\"6 kDa early secretory antigenic target\",\"id\":\"P9WNK7\"},{\"label\":\"Beta-2-microglobulin\",\"id\":\"P61769\"},{\"label\":\"Low molecular weight protein-tyrosine phosphatase A\",\"id\":\"P9WIA1\"},{\"label\":\"Macrophage mannose receptor 1\",\"id\":\"P22897\"},{\"label\":\"Phosphate-binding protein PstS 1\",\"id\":\"P9WGU1\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Possible transcriptional regulatory protein (Probably Lrp/AsnC-family)\",\"id\":\"O33321\"},{\"label\":\"Toll-like receptor 2\",\"id\":\"O60603\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O33321\",\"O60603\",\"P0CG47\",\"P0CG48\",\"P22897\",\"P61769\",\"P62979\",\"P62987\",\"P9WGU1\",\"P9WIA1\",\"P9WNK7\"]", "gene_symbol": "[\"B2M\",\"CLEC13D\",\"CLEC13DL\",\"MRC1\",\"MRC1L1\",\"RPS27A\",\"Rv2779c\",\"TIL4\",\"TLR2\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"esaT6\",\"esxA\",\"mptpA\",\"phoS1\",\"pstS1\",\"ptpA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of E-series 18(R)-resolvins", "protein_name": "[{\"label\":\"Leukotriene A-4 hydrolase\",\"id\":\"P09960\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"},{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX15\",\"id\":\"P16050\"}]", "uniprot_id": "[\"P09917\",\"P09960\",\"P16050\"]", "gene_symbol": "[\"ALOX15\",\"ALOX5\",\"LOG15\",\"LOG5\",\"LTA4\",\"LTA4H\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TRAF3-dependent IRF activation pathway", "protein_name": "[{\"label\":\"Antiviral innate immune response receptor RIG-I\",\"id\":\"O95786\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"E3 ubiquitin-protein ligase RNF135\",\"id\":\"Q8IUD6\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM4\",\"id\":\"Q9C037\"},{\"label\":\"E3 ubiquitin/ISG15 ligase TRIM25\",\"id\":\"Q14258\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit epsilon\",\"id\":\"Q14164\"},{\"label\":\"Interferon beta\",\"id\":\"P01574\"},{\"label\":\"Interferon regulatory factor 3\",\"id\":\"Q14653\"},{\"label\":\"Interferon regulatory factor 7\",\"id\":\"Q92985\"},{\"label\":\"Interferon-induced helicase C domain-containing protein 1\",\"id\":\"Q9BYX4\"},{\"label\":\"Membrane protein\",\"id\":\"P0DTC5\"},{\"label\":\"Mitochondrial antiviral-signaling protein\",\"id\":\"Q7Z434\"},{\"label\":\"Non-structural protein 1\",\"id\":\"P0DOE9\"},{\"label\":\"Serine/threonine-protein kinase TBK1\",\"id\":\"Q9UHD2\"},{\"label\":\"Suppressor of IKBKE 1\",\"id\":\"Q9BRV8\"},{\"label\":\"TNF receptor-associated factor 3\",\"id\":\"Q13114\"}]", "uniprot_id": "[\"O95786\",\"P01574\",\"P0DOE9\",\"P0DTC5\",\"Q09472\",\"Q13114\",\"Q14164\",\"Q14258\",\"Q14653\",\"Q7Z434\",\"Q8IUD6\",\"Q92793\",\"Q92985\",\"Q9BRV8\",\"Q9BYX4\",\"Q9C037\",\"Q9UHD2\"]", "gene_symbol": "[\"1C\",\"CAP-1\",\"CBP\",\"CRAF1\",\"CREBBP\",\"DDX58\",\"EFP\",\"EP300\",\"IFB\",\"IFIH1\",\"IFNB\",\"IFNB1\",\"IKBKE\",\"IKKE\",\"IKKI\",\"IPS1\",\"IRF3\",\"IRF7\",\"KIAA0151\",\"KIAA1271\",\"M\",\"MAVS\",\"MDA5\",\"NAK\",\"NS1\",\"P300\",\"RH116\",\"RIGI\",\"RNF135\",\"RNF147\",\"RNF87\",\"SIKE\",\"SIKE1\",\"TBK1\",\"TRAF3\",\"TRAFAMN\",\"TRIM25\",\"TRIM4\",\"VISA\",\"ZNF147\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Respiratory syncytial virus (RSV) attachment and entry", "protein_name": "[{\"label\":\"Agrin\",\"id\":\"O00468\"},{\"label\":\"Basement membrane-specific heparan sulfate proteoglycan core protein\",\"id\":\"P98160\"},{\"label\":\"CX3C chemokine receptor 1\",\"id\":\"P49238\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Fusion glycoprotein F0\",\"id\":\"P03420\"},{\"label\":\"Glypican-1\",\"id\":\"P35052\"},{\"label\":\"Glypican-2\",\"id\":\"Q8N158\"},{\"label\":\"Glypican-3\",\"id\":\"P51654\"},{\"label\":\"Glypican-4\",\"id\":\"O75487\"},{\"label\":\"Glypican-5\",\"id\":\"P78333\"},{\"label\":\"Glypican-6\",\"id\":\"Q9Y625\"},{\"label\":\"Insulin-like growth factor 1 receptor\",\"id\":\"P08069\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Matrix protein\",\"id\":\"P0DOE7\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Nucleolin\",\"id\":\"P19338\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03418\"},{\"label\":\"Phosphoprotein\",\"id\":\"P03421\"},{\"label\":\"Protein M2-1\",\"id\":\"P04545\"},{\"label\":\"RNA-directed RNA polymerase L\",\"id\":\"P28887\"},{\"label\":\"Ras-related protein Rab-5A\",\"id\":\"P20339\"},{\"label\":\"Ras-related protein Rab-5B\",\"id\":\"P61020\"},{\"label\":\"Ras-related protein Rab-5C\",\"id\":\"P51148\"},{\"label\":\"Syndecan-1\",\"id\":\"P18827\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Syndecan-3\",\"id\":\"O75056\"},{\"label\":\"Syndecan-4\",\"id\":\"P31431\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"}]", "uniprot_id": "[\"O00206\",\"O00468\",\"O75056\",\"O75487\",\"P00533\",\"P03418\",\"P03420\",\"P03421\",\"P04545\",\"P08069\",\"P08571\",\"P09958\",\"P0DOE7\",\"P18827\",\"P19338\",\"P20339\",\"P28887\",\"P31431\",\"P34741\",\"P35052\",\"P49238\",\"P51148\",\"P51654\",\"P61020\",\"P78333\",\"P98160\",\"Q8N158\",\"Q9Y625\",\"Q9Y6Y9\"]", "gene_symbol": "[\"AGRIN\",\"AGRN\",\"CD14\",\"CMKBRL1\",\"CX3CR1\",\"EGFR\",\"ERBB\",\"ERBB1\",\"ESOP1\",\"F\",\"FUR\",\"FURIN\",\"GPC1\",\"GPC2\",\"GPC3\",\"GPC4\",\"GPC5\",\"GPC6\",\"GPR13\",\"HER1\",\"HSPG1\",\"HSPG2\",\"IGF1R\",\"KIAA0468\",\"L\",\"LY96\",\"M\",\"M2-1\",\"MD2\",\"N\",\"NCL\",\"OCI5\",\"P\",\"PACE\",\"PCSK3\",\"RAB5\",\"RAB5A\",\"RAB5B\",\"RAB5C\",\"RABL\",\"SDC\",\"SDC1\",\"SDC2\",\"SDC3\",\"SDC4\",\"TLR4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)", "protein_name": "[{\"label\":\"Sodium-dependent phosphate transport protein 2B\",\"id\":\"O95436\"}]", "uniprot_id": "[\"O95436\"]", "gene_symbol": "[\"SLC34A2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ketone body catabolism", "protein_name": "[{\"label\":\"Acetyl-CoA acetyltransferase, mitochondrial\",\"id\":\"P24752\"},{\"label\":\"D-beta-hydroxybutyrate dehydrogenase, mitochondrial\",\"id\":\"Q02338\"},{\"label\":\"Succinyl-CoA\",\"id\":\"3-ketoacid coenzyme A transferase 1, mitochondrial:P55809\"},{\"label\":\"Succinyl-CoA\",\"id\":\"3-ketoacid coenzyme A transferase 2, mitochondrial:Q9BYC2\"}]", "uniprot_id": "[\"P24752\",\"P55809\",\"Q02338\",\"Q9BYC2\"]", "gene_symbol": "[\"ACAT\",\"ACAT1\",\"BDH\",\"BDH1\",\"MAT\",\"OXCT\",\"OXCT1\",\"OXCT2\",\"SCOT\",\"SDR9C1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RHO GTPases regulate CFTR trafficking", "protein_name": "[{\"label\":\"Cystic fibrosis transmembrane conductance regulator\",\"id\":\"P13569\"},{\"label\":\"Golgi-associated PDZ and coiled-coil motif-containing protein\",\"id\":\"Q9HD26\"},{\"label\":\"Rho-related GTP-binding protein RhoQ\",\"id\":\"P17081\"}]", "uniprot_id": "[\"P13569\",\"P17081\",\"Q9HD26\"]", "gene_symbol": "[\"ABCC7\",\"ARHQ\",\"CAL\",\"CFTR\",\"FIG\",\"GOPC\",\"RASL7A\",\"RHOQ\",\"TC10\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Estrogen-dependent gene expression", "protein_name": "[{\"label\":\"Apoptosis regulator Bcl-2\",\"id\":\"P10415\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"BTB/POZ domain-containing protein KCTD6\",\"id\":\"Q8NC69\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"CXXC-type zinc finger protein 5\",\"id\":\"Q7LFL8\"},{\"label\":\"Cathepsin D\",\"id\":\"P07339\"},{\"label\":\"Cbp/p300-interacting transactivator 1\",\"id\":\"Q99966\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 1\",\"id\":\"O14646\"},{\"label\":\"Cohesin subunit SA-1\",\"id\":\"Q8WVM7\"},{\"label\":\"Cohesin subunit SA-2\",\"id\":\"Q8N3U4\"},{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-2\",\"id\":\"P15336\"},{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Double-strand-break repair protein rad21 homolog\",\"id\":\"O60216\"},{\"label\":\"Estrogen receptor\",\"id\":\"P03372\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 1, mitochondrial\",\"id\":\"Q9HCL2\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Hepatocyte nuclear factor 3-alpha\",\"id\":\"P55317\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H3.3\",\"id\":\"P84243\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone-arginine methyltransferase CARM1\",\"id\":\"Q86X55\"},{\"label\":\"Importin subunit alpha-1\",\"id\":\"P52292\"},{\"label\":\"KN motif and ankyrin repeat domain-containing protein 1\",\"id\":\"Q14678\"},{\"label\":\"Lysine-specific demethylase 4B\",\"id\":\"O94953\"},{\"label\":\"Lysine-specific histone demethylase 1A\",\"id\":\"O60341\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 1\",\"id\":\"Q15648\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Nuclear receptor coactivator 3\",\"id\":\"Q9Y6Q9\"},{\"label\":\"Nuclear receptor subfamily 5 group A member 2\",\"id\":\"O00482\"},{\"label\":\"Nuclear receptor-interacting protein 1\",\"id\":\"P48552\"},{\"label\":\"POU domain, class 2, transcription factor 1\",\"id\":\"P14859\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase FKBP4\",\"id\":\"Q02790\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX5\",\"id\":\"P17844\"},{\"label\":\"Progesterone receptor\",\"id\":\"P06401\"},{\"label\":\"Prostaglandin E synthase 3\",\"id\":\"Q15185\"},{\"label\":\"Protein FosB\",\"id\":\"P53539\"},{\"label\":\"Protein GREB1\",\"id\":\"Q4ZG55\"},{\"label\":\"Protein arginine N-methyltransferase 1\",\"id\":\"Q99873\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Protein c-Fos\",\"id\":\"P01100\"},{\"label\":\"Protransforming growth factor alpha\",\"id\":\"P01135\"},{\"label\":\"Receptor-binding cancer antigen expressed on SiSo cells\",\"id\":\"O00559\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"},{\"label\":\"Stromal cell-derived factor 1\",\"id\":\"P48061\"},{\"label\":\"Structural maintenance of chromosomes protein 1A\",\"id\":\"Q14683\"},{\"label\":\"Structural maintenance of chromosomes protein 3\",\"id\":\"Q9UQE7\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Trans-acting T-cell-specific transcription factor GATA-3\",\"id\":\"P23771\"},{\"label\":\"Transcription factor 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acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT1\",\"id\":\"Q9H9B1\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT2\",\"id\":\"Q96KQ7\"},{\"label\":\"Junction-mediating and -regulatory protein\",\"id\":\"Q8N9B5\"},{\"label\":\"Lethal(3)malignant brain tumor-like protein 1\",\"id\":\"Q9Y468\"},{\"label\":\"N-lysine methyltransferase KMT5A\",\"id\":\"Q9NQR1\"},{\"label\":\"N-lysine methyltransferase SMYD2\",\"id\":\"Q9NRG4\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein Mdm4\",\"id\":\"O15151\"},{\"label\":\"Protein arginine N-methyltransferase 5\",\"id\":\"O14744\"},{\"label\":\"SET domain-containing protein 9\",\"id\":\"Q8NE22\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"Serine/threonine-protein kinase Chk2\",\"id\":\"O96017\"},{\"label\":\"Tetratricopeptide repeat protein 5\",\"id\":\"Q8N0Z6\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O14744\",\"O15151\",\"O96017\",\"P04637\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q00987\",\"Q09472\",\"Q13315\",\"Q8N0Z6\",\"Q8N9B5\",\"Q8NE22\",\"Q96KQ7\",\"Q9H9B1\",\"Q9NQR1\",\"Q9NRG4\",\"Q9Y468\"]", "gene_symbol": "[\"ATM\",\"BAT8\",\"C5orf35\",\"C6orf30\",\"CDS1\",\"CHEK2\",\"CHK2\",\"EHMT1\",\"EHMT2\",\"EP300\",\"EUHMTASE1\",\"G9A\",\"GLP\",\"HRMT1L5\",\"IBP72\",\"JBP1\",\"JMY\",\"KIAA0681\",\"KIAA1876\",\"KMT1C\",\"KMT1D\",\"KMT3C\",\"KMT5A\",\"L3MBT\",\"L3MBTL\",\"L3MBTL1\",\"MDM2\",\"MDM4\",\"MDMX\",\"NG36\",\"P300\",\"P53\",\"PRMT5\",\"PRSET7\",\"RAD53\",\"RPS27A\",\"SET07\",\"SET8\",\"SETD8\",\"SETD9\",\"SKB1\",\"SMYD2\",\"TP53\",\"TTC5\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Inhibition of PKR", 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"gtc_id": "[\"\"]" }, { "pathway_label": "Uptake and function of anthrax toxins", "protein_name": "[{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Calmodulin-sensitive adenylate cyclase\",\"id\":\"P40136\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 1\",\"id\":\"Q02750\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 2\",\"id\":\"P36507\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 4\",\"id\":\"P45985\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 7\",\"id\":\"O14733\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Lethal factor\",\"id\":\"P15917\"},{\"label\":\"Programmed cell death 6-interacting protein\",\"id\":\"Q8WUM4\"},{\"label\":\"Protective antigen\",\"id\":\"P13423\"}]", "uniprot_id": "[\"O14733\",\"P09958\",\"P0DP23\",\"P13423\",\"P15917\",\"P36507\",\"P40136\",\"P45985\",\"Q02750\",\"Q8WUM4\"]", "gene_symbol": 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ATM\",\"id\":\"Q13315\"},{\"label\":\"Tumor protein 63\",\"id\":\"Q9H3D4\"},{\"label\":\"Tumor protein p73\",\"id\":\"O15350\"},{\"label\":\"p53-induced death domain-containing protein 1\",\"id\":\"Q9HB75\"}]", "uniprot_id": "[\"O14727\",\"O15350\",\"P04637\",\"P29466\",\"P42575\",\"P55212\",\"P78560\",\"Q13315\",\"Q92851\",\"Q9H3D4\",\"Q9HB75\",\"Q9NPP4\"]", "gene_symbol": "[\"APAF1\",\"ATM\",\"CARD12\",\"CASP1\",\"CASP10\",\"CASP2\",\"CASP6\",\"CLAN\",\"CLAN1\",\"CRADD\",\"ICH1\",\"IL1BC\",\"IL1BCE\",\"IPAF\",\"KET\",\"KIAA0413\",\"LRDD\",\"MCH2\",\"MCH4\",\"NEDD2\",\"NLRC4\",\"P53\",\"P63\",\"P73\",\"P73H\",\"P73L\",\"PIDD\",\"PIDD1\",\"RAIDD\",\"TP53\",\"TP63\",\"TP73\",\"TP73L\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "APOBEC3G mediated resistance to HIV-1 infection", "protein_name": "[{\"label\":\"Barrier-to-autointegration factor\",\"id\":\"O75531\"},{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"High mobility group protein HMG-I/HMG-Y\",\"id\":\"P17096\"},{\"label\":\"PC4 and SFRS1-interacting protein\",\"id\":\"O75475\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Protein Rev\",\"id\":\"P04618\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"O75475\",\"O75531\",\"P04585\",\"P04591\",\"P04618\",\"P05919\",\"P17096\",\"P62937\",\"P69723\",\"P69726\"]", "gene_symbol": "[\"BAF\",\"BANF1\",\"BCRG1\",\"CYPA\",\"DFS70\",\"HMGA1\",\"HMGIY\",\"LEDGF\",\"PPIA\",\"PSIP1\",\"PSIP2\",\"gag\",\"gag-pol\",\"rev\",\"vif\",\"vpr\",\"vpu\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC7A9 causes cystinuria (CSNU)", "protein_name": "[{\"label\":\"Amino acid transporter heavy chain SLC3A1\",\"id\":\"Q07837\"},{\"label\":\"b(0,+)-type amino acid transporter 1\",\"id\":\"P82251\"}]", "uniprot_id": "[\"P82251\",\"Q07837\"]", "gene_symbol": "[\"BAT1\",\"NBAT\",\"SLC3A1\",\"SLC7A9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective PMM2 causes CDG-1a", "protein_name": "[{\"label\":\"Phosphomannomutase 2\",\"id\":\"O15305\"}]", "uniprot_id": "[\"O15305\"]", "gene_symbol": "[\"PMM2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Recycling of eIF2:GDP", "protein_name": "[{\"label\":\"Eukaryotic translation initiation factor 2 subunit 1\",\"id\":\"P05198\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 2\",\"id\":\"P20042\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 3\",\"id\":\"P41091\"},{\"label\":\"Translation initiation factor eIF2B subunit alpha\",\"id\":\"Q14232\"},{\"label\":\"Translation initiation factor eIF2B subunit beta\",\"id\":\"P49770\"},{\"label\":\"Translation initiation factor eIF2B subunit delta\",\"id\":\"Q9UI10\"},{\"label\":\"Translation initiation factor eIF2B subunit epsilon\",\"id\":\"Q13144\"},{\"label\":\"Translation initiation factor eIF2B subunit gamma\",\"id\":\"Q9NR50\"}]", "uniprot_id": "[\"P05198\",\"P20042\",\"P41091\",\"P49770\",\"Q13144\",\"Q14232\",\"Q9NR50\",\"Q9UI10\"]", "gene_symbol": "[\"EIF2A\",\"EIF2B\",\"EIF2B1\",\"EIF2B2\",\"EIF2B3\",\"EIF2B4\",\"EIF2B5\",\"EIF2BA\",\"EIF2BB\",\"EIF2BD\",\"EIF2BE\",\"EIF2G\",\"EIF2S1\",\"EIF2S2\",\"EIF2S3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of PIPs at the early endosome membrane", "protein_name": "[{\"label\":\"1-phosphatidylinositol 3-phosphate 5-kinase\",\"id\":\"Q9Y2I7\"},{\"label\":\"Inositol polyphosphate 4-phosphatase type II\",\"id\":\"O15327\"},{\"label\":\"Inositol polyphosphate-4-phosphatase type I A\",\"id\":\"Q96PE3\"},{\"label\":\"Myotubularin-related protein 10\",\"id\":\"Q9NXD2\"},{\"label\":\"Myotubularin-related protein 12\",\"id\":\"Q9C0I1\"},{\"label\":\"Myotubularin\",\"id\":\"Q13496\"},{\"label\":\"Phosphatidylinositide phosphatase SAC2\",\"id\":\"Q9Y2H2\"},{\"label\":\"Phosphatidylinositol 3-kinase catalytic subunit type 3\",\"id\":\"Q8NEB9\"},{\"label\":\"Phosphatidylinositol 4-kinase type 2-alpha\",\"id\":\"Q9BTU6\"},{\"label\":\"Phosphatidylinositol 4-kinase type 2-beta\",\"id\":\"Q8TCG2\"},{\"label\":\"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha\",\"id\":\"O00443\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2\",\"id\":\"Q13614\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4\",\"id\":\"Q9NYA4\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 4\",\"id\":\"Q99570\"},{\"label\":\"Polyphosphoinositide phosphatase\",\"id\":\"Q92562\"},{\"label\":\"Protein VAC14 homolog\",\"id\":\"Q08AM6\"}]", "uniprot_id": "[\"O00443\",\"O15327\",\"Q08AM6\",\"Q13496\",\"Q13614\",\"Q8NEB9\",\"Q8TCG2\",\"Q92562\",\"Q96PE3\",\"Q99570\",\"Q9BTU6\",\"Q9C0I1\",\"Q9NXD2\",\"Q9NYA4\",\"Q9Y2H2\",\"Q9Y2I7\"]", "gene_symbol": 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Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"P04049\",\"P04275\",\"P07359\",\"P13224\",\"P14770\",\"P21333\",\"P27986\",\"P40197\",\"P63104\"]", "gene_symbol": "[\"F8VWF\",\"FLN\",\"FLN1\",\"FLNA\",\"GP1BA\",\"GP1BB\",\"GP5\",\"GP9\",\"GRB1\",\"PIK3R1\",\"RAF\",\"RAF1\",\"VWF\",\"YWHAZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective GALNT3 causes HFTC", "protein_name": 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acetylcholine receptor subunit alpha-4\",\"id\":\"P43681\"},{\"label\":\"Neuronal acetylcholine receptor subunit beta-2\",\"id\":\"P17787\"},{\"label\":\"Neuronal acetylcholine receptor subunit beta-4\",\"id\":\"P30926\"}]", "uniprot_id": "[\"P07510\",\"P17787\",\"P30926\",\"P32297\",\"P43681\",\"Q04844\",\"Q07001\"]", "gene_symbol": "[\"ACHRD\",\"ACHRE\",\"ACHRG\",\"CHRNA3\",\"CHRNA4\",\"CHRNB2\",\"CHRNB4\",\"CHRND\",\"CHRNE\",\"CHRNG\",\"NACHRA3\",\"NACRA4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of EPA-derived SPMs", "protein_name": "[{\"label\":\"Prostaglandin G/H synthase 2\",\"id\":\"P35354\"}]", "uniprot_id": "[\"P35354\"]", "gene_symbol": "[\"COX2\",\"PTGS2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mitotic Prometaphase", "protein_name": "[{\"label\":\"Aurora kinase B\",\"id\":\"Q96GD4\"},{\"label\":\"B9 domain-containing protein 2\",\"id\":\"Q9BPU9\"},{\"label\":\"Baculoviral IAP repeat-containing protein 5\",\"id\":\"O15392\"},{\"label\":\"Borealin\",\"id\":\"Q53HL2\"},{\"label\":\"CAP-Gly domain-containing linker protein 1\",\"id\":\"P30622\"},{\"label\":\"CLIP-associating protein 1\",\"id\":\"Q7Z460\"},{\"label\":\"CLIP-associating protein 2\",\"id\":\"O75122\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Centromere protein C\",\"id\":\"Q03188\"},{\"label\":\"Centromere protein F\",\"id\":\"P49454\"},{\"label\":\"Centromere protein H\",\"id\":\"Q9H3R5\"},{\"label\":\"Centromere protein I\",\"id\":\"Q92674\"},{\"label\":\"Centromere protein K\",\"id\":\"Q9BS16\"},{\"label\":\"Centromere protein L\",\"id\":\"Q8N0S6\"},{\"label\":\"Centromere protein M\",\"id\":\"Q9NSP4\"},{\"label\":\"Centromere protein N\",\"id\":\"Q96H22\"},{\"label\":\"Centromere protein O\",\"id\":\"Q9BU64\"},{\"label\":\"Centromere protein P\",\"id\":\"Q6IPU0\"},{\"label\":\"Centromere protein Q\",\"id\":\"Q7L2Z9\"},{\"label\":\"Centromere protein R\",\"id\":\"Q13352\"},{\"label\":\"Centromere protein S\",\"id\":\"Q8N2Z9\"},{\"label\":\"Centromere protein T\",\"id\":\"Q96BT3\"},{\"label\":\"Centromere protein U\",\"id\":\"Q71F23\"},{\"label\":\"Centromere-associated protein E\",\"id\":\"Q02224\"},{\"label\":\"Centromere/kinetochore protein zw10 homolog\",\"id\":\"O43264\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 1\",\"id\":\"O14576\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 2\",\"id\":\"O43237\"},{\"label\":\"Cytoskeleton-associated protein 5\",\"id\":\"Q14008\"},{\"label\":\"DNA excision repair protein ERCC-6-like\",\"id\":\"Q2NKX8\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"Histone H3-like centromeric protein A\",\"id\":\"P49450\"},{\"label\":\"Inner centromere protein\",\"id\":\"Q9NQS7\"},{\"label\":\"Kinesin-like protein KIF18A\",\"id\":\"Q8NI77\"},{\"label\":\"Kinesin-like protein KIF2A\",\"id\":\"O00139\"},{\"label\":\"Kinesin-like protein KIF2B\",\"id\":\"Q8N4N8\"},{\"label\":\"Kinesin-like protein KIF2C\",\"id\":\"Q99661\"},{\"label\":\"Kinetochore protein NDC80 homolog\",\"id\":\"O14777\"},{\"label\":\"Kinetochore protein Nuf2\",\"id\":\"Q9BZD4\"},{\"label\":\"Kinetochore protein Spc24\",\"id\":\"Q8NBT2\"},{\"label\":\"Kinetochore protein Spc25\",\"id\":\"Q9HBM1\"},{\"label\":\"Kinetochore scaffold 1\",\"id\":\"Q8NG31\"},{\"label\":\"Kinetochore-associated protein 1\",\"id\":\"P50748\"},{\"label\":\"Kinetochore-associated protein DSN1 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phosphatase PP1-gamma catalytic subunit\",\"id\":\"P36873\"},{\"label\":\"Shugoshin 1\",\"id\":\"Q5FBB7\"},{\"label\":\"Shugoshin 2\",\"id\":\"Q562F6\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Spindle and kinetochore-associated protein 2\",\"id\":\"Q8WVK7\"},{\"label\":\"ZW10 interactor\",\"id\":\"O95229\"}]", "uniprot_id": 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2\",\"id\":\"P06821\"},{\"label\":\"Neuraminidase\",\"id\":\"P03468\"},{\"label\":\"Nuclear export protein\",\"id\":\"P03508\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"}]", "uniprot_id": "[\"P03428\",\"P03431\",\"P03433\",\"P03452\",\"P03466\",\"P03468\",\"P03485\",\"P03508\",\"P06821\"]", "gene_symbol": "[\"HA\",\"M\",\"NA\",\"NP\",\"NS\",\"PA\",\"PB1\",\"PB2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "The retinoid cycle in cones (daylight vision)", "protein_name": "[{\"label\":\"Acyl-CoA wax alcohol acyltransferase 2\",\"id\":\"Q6E213\"},{\"label\":\"Long-wave-sensitive opsin 1\",\"id\":\"P04000\"},{\"label\":\"Medium-wave-sensitive opsin 1\",\"id\":\"P04001\"},{\"label\":\"Retinaldehyde-binding protein 1\",\"id\":\"P12271\"},{\"label\":\"Retinol-binding protein 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subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Inward rectifier potassium channel 16\",\"id\":\"Q9NPI9\"},{\"label\":\"Inward rectifier potassium channel 2\",\"id\":\"P63252\"},{\"label\":\"Inward rectifier potassium channel 4\",\"id\":\"P48050\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O60262\",\"O75899\",\"P16520\",\"P48050\",\"P48051\",\"P48544\",\"P48549\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63211\",\"P63215\",\"P63218\",\"P63252\",\"P78508\",\"Q14500\",\"Q92806\",\"Q99712\",\"Q9HAV0\",\"Q9NPI9\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UBS5\",\"Q9UK08\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Transfer of LPS from LBP carrier to CD14", "protein_name": "[{\"label\":\"Lipopolysaccharide-binding protein\",\"id\":\"P18428\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"}]", "uniprot_id": "[\"P08571\",\"P18428\"]", "gene_symbol": "[\"CD14\",\"LBP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1", "protein_name": "[{\"label\":\"Cyclin-A2\",\"id\":\"P20248\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Myb-related protein B\",\"id\":\"P10244\"},{\"label\":\"Protein lin-37 homolog\",\"id\":\"Q96GY3\"},{\"label\":\"Protein lin-52 homolog\",\"id\":\"Q52LA3\"},{\"label\":\"Protein lin-54 homolog\",\"id\":\"Q6MZP7\"},{\"label\":\"Protein lin-9 homolog\",\"id\":\"Q5TKA1\"},{\"label\":\"Retinoblastoma-like protein 1\",\"id\":\"P28749\"},{\"label\":\"Retinoblastoma-like protein 2\",\"id\":\"Q08999\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Transcription factor E2F4\",\"id\":\"Q16254\"},{\"label\":\"Transcription factor E2F5\",\"id\":\"Q15329\"}]", "uniprot_id": "[\"P06493\",\"P10244\",\"P20248\",\"P28749\",\"Q01094\",\"Q08999\",\"Q09028\",\"Q13547\",\"Q14186\",\"Q14188\",\"Q15329\",\"Q16254\",\"Q52LA3\",\"Q5TKA1\",\"Q6MZP7\",\"Q96GY3\"]", "gene_symbol": "[\"BARA\",\"BMYB\",\"C14orf46\",\"CCN1\",\"CCNA\",\"CCNA2\",\"CDC2\",\"CDC28A\",\"CDK1\",\"CDKN1\",\"CXCDC1\",\"DP1\",\"DP2\",\"E2F1\",\"E2F4\",\"E2F5\",\"HDAC1\",\"KIAA2037\",\"LIN37\",\"LIN52\",\"LIN54\",\"LIN9\",\"MYBL2\",\"P34CDC2\",\"RB2\",\"RBAP48\",\"RBBP3\",\"RBBP4\",\"RBL1\",\"RBL2\",\"RPD3L1\",\"TFDP1\",\"TFDP2\",\"TGS\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "eNOS activation", "protein_name": "[{\"label\":\"Acyl-protein thioesterase 1\",\"id\":\"O75608\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Cytochrome b5 type B\",\"id\":\"O43169\"},{\"label\":\"Cytoglobin\",\"id\":\"Q8WWM9\"},{\"label\":\"Glycylpeptide N-tetradecanoyltransferase 1\",\"id\":\"P30419\"},{\"label\":\"Glycylpeptide N-tetradecanoyltransferase 2\",\"id\":\"O60551\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"N(G),N(G)-dimethylarginine dimethylaminohydrolase 1\",\"id\":\"O94760\"},{\"label\":\"Nitric oxide synthase 3\",\"id\":\"P29474\"},{\"label\":\"Palmitoyltransferase ZDHHC21\",\"id\":\"Q8IVQ6\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"Sepiapterin reductase\",\"id\":\"P35270\"}]", "uniprot_id": "[\"O43169\",\"O60551\",\"O75608\",\"O94760\",\"P07900\",\"P0DP23\",\"P29474\",\"P30419\",\"P31749\",\"P35270\",\"Q03135\",\"Q8IVQ6\",\"Q8WWM9\"]", "gene_symbol": "[\"AKT1\",\"APT1\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAV\",\"CAV1\",\"CYB5B\",\"CYB5M\",\"CYGB\",\"DDAH\",\"DDAH1\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"LPL1\",\"LYPLA1\",\"NMT\",\"NMT1\",\"NMT2\",\"NOS3\",\"OMB5\",\"PKB\",\"RAC\",\"SPR\",\"STAP\",\"ZDHHC21\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Antigen processing: Ubiquitination & Proteasome degradation", "protein_name": "[{\"label\":\"(E3-independent) E2 ubiquitin-conjugating enzyme\",\"id\":\"Q9C0C9\"},{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 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protein 11\",\"id\":\"Q8WXH4\"},{\"label\":\"Ankyrin repeat and SOCS box protein 12\",\"id\":\"Q8WXK4\"},{\"label\":\"Ankyrin repeat and SOCS box protein 13\",\"id\":\"Q8WXK3\"},{\"label\":\"Ankyrin repeat and SOCS box protein 14\",\"id\":\"A6NK59\"},{\"label\":\"Ankyrin repeat and SOCS box protein 15\",\"id\":\"Q8WXK1\"},{\"label\":\"Ankyrin repeat and SOCS box protein 16\",\"id\":\"Q96NS5\"},{\"label\":\"Ankyrin repeat and SOCS box protein 17\",\"id\":\"Q8WXJ9\"},{\"label\":\"Ankyrin repeat and SOCS box protein 18\",\"id\":\"Q6ZVZ8\"},{\"label\":\"Ankyrin repeat and SOCS box protein 1\",\"id\":\"Q9Y576\"},{\"label\":\"Ankyrin repeat and SOCS box protein 2\",\"id\":\"Q96Q27\"},{\"label\":\"Ankyrin repeat and SOCS box protein 3\",\"id\":\"Q9Y575\"},{\"label\":\"Ankyrin repeat and SOCS box protein 4\",\"id\":\"Q9Y574\"},{\"label\":\"Ankyrin repeat and SOCS box protein 5\",\"id\":\"Q8WWX0\"},{\"label\":\"Ankyrin repeat and SOCS box protein 6\",\"id\":\"Q9NWX5\"},{\"label\":\"Ankyrin 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TRIM63\",\"id\":\"Q969Q1\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM69\",\"id\":\"Q86WT6\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM71\",\"id\":\"Q2Q1W2\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM9\",\"id\":\"Q9C026\"},{\"label\":\"E3 ubiquitin-protein ligase TRIP12\",\"id\":\"Q14669\"},{\"label\":\"E3 ubiquitin-protein ligase UBR1\",\"id\":\"Q8IWV7\"},{\"label\":\"E3 ubiquitin-protein ligase UBR2\",\"id\":\"Q8IWV8\"},{\"label\":\"E3 ubiquitin-protein ligase UBR4\",\"id\":\"Q5T4S7\"},{\"label\":\"E3 ubiquitin-protein ligase ZNRF1\",\"id\":\"Q8ND25\"},{\"label\":\"E3 ubiquitin-protein ligase ZNRF2\",\"id\":\"Q8NHG8\"},{\"label\":\"E3 ubiquitin-protein ligase listerin\",\"id\":\"O94822\"},{\"label\":\"E3 ubiquitin-protein ligase makorin-1\",\"id\":\"Q9UHC7\"},{\"label\":\"E3 ubiquitin-protein ligase parkin\",\"id\":\"O60260\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"F-box and leucine-rich protein 22\",\"id\":\"Q6P050\"},{\"label\":\"F-box and leucine-rich repeat protein 13\",\"id\":\"Q8NEE6\"},{\"label\":\"F-box only protein 10\",\"id\":\"Q9UK96\"},{\"label\":\"F-box only protein 11\",\"id\":\"Q86XK2\"},{\"label\":\"F-box only protein 15\",\"id\":\"Q8NCQ5\"},{\"label\":\"F-box only protein 17\",\"id\":\"Q96EF6\"},{\"label\":\"F-box only protein 21\",\"id\":\"O94952\"},{\"label\":\"F-box only protein 22\",\"id\":\"Q8NEZ5\"},{\"label\":\"F-box only protein 27\",\"id\":\"Q8NI29\"},{\"label\":\"F-box only protein 2\",\"id\":\"Q9UK22\"},{\"label\":\"F-box only protein 30\",\"id\":\"Q8TB52\"},{\"label\":\"F-box only protein 31\",\"id\":\"Q5XUX0\"},{\"label\":\"F-box only protein 32\",\"id\":\"Q969P5\"},{\"label\":\"F-box only protein 40\",\"id\":\"Q9UH90\"},{\"label\":\"F-box only protein 41\",\"id\":\"Q8TF61\"},{\"label\":\"F-box only protein 44\",\"id\":\"Q9H4M3\"},{\"label\":\"F-box only protein 4\",\"id\":\"Q9UKT5\"},{\"label\":\"F-box only protein 6\",\"id\":\"Q9NRD1\"},{\"label\":\"F-box only protein 7\",\"id\":\"Q9Y3I1\"},{\"label\":\"F-box only protein 9\",\"id\":\"Q9UK97\"},{\"label\":\"F-box/LRR-repeat protein 12\",\"id\":\"Q9NXK8\"},{\"label\":\"F-box/LRR-repeat protein 14\",\"id\":\"Q8N1E6\"},{\"label\":\"F-box/LRR-repeat protein 15\",\"id\":\"Q9H469\"},{\"label\":\"F-box/LRR-repeat protein 16\",\"id\":\"Q8N461\"},{\"label\":\"F-box/LRR-repeat protein 18\",\"id\":\"Q96ME1\"},{\"label\":\"F-box/LRR-repeat protein 19\",\"id\":\"Q6PCT2\"},{\"label\":\"F-box/LRR-repeat protein 20\",\"id\":\"Q96IG2\"},{\"label\":\"F-box/LRR-repeat protein 3\",\"id\":\"Q9UKT7\"},{\"label\":\"F-box/LRR-repeat protein 4\",\"id\":\"Q9UKA2\"},{\"label\":\"F-box/LRR-repeat protein 5\",\"id\":\"Q9UKA1\"},{\"label\":\"F-box/LRR-repeat protein 7\",\"id\":\"Q9UJT9\"},{\"label\":\"F-box/LRR-repeat protein 8\",\"id\":\"Q96CD0\"},{\"label\":\"F-box/WD repeat-containing protein 10\",\"id\":\"Q5XX13\"},{\"label\":\"F-box/WD repeat-containing protein 11\",\"id\":\"Q9UKB1\"},{\"label\":\"F-box/WD repeat-containing protein 12\",\"id\":\"Q6X9E4\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"F-box/WD repeat-containing protein 2\",\"id\":\"Q9UKT8\"},{\"label\":\"F-box/WD repeat-containing protein 4\",\"id\":\"P57775\"},{\"label\":\"F-box/WD repeat-containing protein 5\",\"id\":\"Q969U6\"},{\"label\":\"F-box/WD repeat-containing protein 7\",\"id\":\"Q969H0\"},{\"label\":\"F-box/WD repeat-containing protein 8\",\"id\":\"Q8N3Y1\"},{\"label\":\"F-box/WD repeat-containing protein 9\",\"id\":\"Q5XUX1\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"Gigaxonin\",\"id\":\"Q9H2C0\"},{\"label\":\"Glomulin\",\"id\":\"Q92990\"},{\"label\":\"Kelch repeat and BTB domain-containing protein 13\",\"id\":\"C9JR72\"},{\"label\":\"Kelch repeat and BTB domain-containing protein 6\",\"id\":\"Q86V97\"},{\"label\":\"Kelch repeat and BTB domain-containing protein 7\",\"id\":\"Q8WVZ9\"},{\"label\":\"Kelch repeat and BTB domain-containing protein 8\",\"id\":\"Q8NFY9\"},{\"label\":\"Kelch-like ECH-associated protein 1\",\"id\":\"Q14145\"},{\"label\":\"Kelch-like protein 11\",\"id\":\"Q9NVR0\"},{\"label\":\"Kelch-like protein 13\",\"id\":\"Q9P2N7\"},{\"label\":\"Kelch-like protein 20\",\"id\":\"Q9Y2M5\"},{\"label\":\"Kelch-like protein 21\",\"id\":\"Q9UJP4\"},{\"label\":\"Kelch-like protein 22\",\"id\":\"Q53GT1\"},{\"label\":\"Kelch-like protein 25\",\"id\":\"Q9H0H3\"},{\"label\":\"Kelch-like protein 2\",\"id\":\"O95198\"},{\"label\":\"Kelch-like protein 3\",\"id\":\"Q9UH77\"},{\"label\":\"Kelch-like protein 41\",\"id\":\"O60662\"},{\"label\":\"Kelch-like protein 42\",\"id\":\"Q9P2K6\"},{\"label\":\"Kelch-like protein 5\",\"id\":\"Q96PQ7\"},{\"label\":\"Kelch-like protein 9\",\"id\":\"Q9P2J3\"},{\"label\":\"LIM domain only protein 7\",\"id\":\"Q8WWI1\"},{\"label\":\"LON peptidase N-terminal domain and RING finger protein 1\",\"id\":\"Q17RB8\"},{\"label\":\"Leucine-rich repeat protein 1\",\"id\":\"Q96L50\"},{\"label\":\"Leucine-rich repeat-containing protein 41\",\"id\":\"Q15345\"},{\"label\":\"Leucyl-cystinyl aminopeptidase\",\"id\":\"Q9UIQ6\"},{\"label\":\"NEDD4-like E3 ubiquitin-protein ligase WWP1\",\"id\":\"Q9H0M0\"},{\"label\":\"NEDD8-activating enzyme E1 catalytic subunit\",\"id\":\"Q8TBC4\"},{\"label\":\"NEDD8-conjugating enzyme UBE2F\",\"id\":\"Q969M7\"},{\"label\":\"NEDD8-conjugating enzyme Ubc12\",\"id\":\"P61081\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Probable E3 ubiquitin-protein ligase HECTD2\",\"id\":\"Q5U5R9\"},{\"label\":\"Probable E3 ubiquitin-protein ligase HERC1\",\"id\":\"Q15751\"},{\"label\":\"Probable E3 ubiquitin-protein ligase HERC3\",\"id\":\"Q15034\"},{\"label\":\"Probable E3 ubiquitin-protein ligase HERC4\",\"id\":\"Q5GLZ8\"},{\"label\":\"Probable E3 ubiquitin-protein ligase HERC6\",\"id\":\"Q8IVU3\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Puromycin-sensitive aminopeptidase\",\"id\":\"P55786\"},{\"label\":\"Putative E3 ubiquitin-protein ligase UNKL\",\"id\":\"Q9H9P5\"},{\"label\":\"Putative F-box/LRR-repeat protein 21\",\"id\":\"Q9UKT6\"},{\"label\":\"RING finger and CHY zinc finger domain-containing protein 1\",\"id\":\"Q96PM5\"},{\"label\":\"RING finger protein 37\",\"id\":\"O94941\"},{\"label\":\"RING-box protein 2\",\"id\":\"Q9UBF6\"},{\"label\":\"RNA-binding E3 ubiquitin-protein ligase MEX3C\",\"id\":\"Q5U5Q3\"},{\"label\":\"RanBP-type and C3HC4-type zinc finger-containing protein 1\",\"id\":\"Q9BYM8\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"S-phase kinase-associated protein 2\",\"id\":\"Q13309\"},{\"label\":\"SPRY domain-containing SOCS box protein 1\",\"id\":\"Q96BD6\"},{\"label\":\"SPRY domain-containing SOCS box protein 2\",\"id\":\"Q99619\"},{\"label\":\"SPRY domain-containing SOCS box protein 4\",\"id\":\"Q96A44\"},{\"label\":\"Suppressor of cytokine signaling 1\",\"id\":\"O15524\"},{\"label\":\"Suppressor of cytokine signaling 3\",\"id\":\"O14543\"},{\"label\":\"Thimet oligopeptidase\",\"id\":\"P52888\"},{\"label\":\"Tripeptidyl-peptidase 2\",\"id\":\"P29144\"},{\"label\":\"Ubiquitin conjugation factor E4 A\",\"id\":\"Q14139\"},{\"label\":\"Ubiquitin-associated domain-containing protein 1\",\"id\":\"Q9BSL1\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 A\",\"id\":\"P49459\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 B\",\"id\":\"P63146\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D2\",\"id\":\"P62837\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D3\",\"id\":\"P61077\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D4\",\"id\":\"Q9Y2X8\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E2\",\"id\":\"Q96LR5\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E3\",\"id\":\"Q969T4\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 G1\",\"id\":\"P62253\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 G2\",\"id\":\"P60604\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 H\",\"id\":\"P62256\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 J1\",\"id\":\"Q9Y385\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 J2\",\"id\":\"Q8N2K1\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 K\",\"id\":\"P61086\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 L3\",\"id\":\"P68036\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 Q1\",\"id\":\"Q7Z7E8\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 Q2\",\"id\":\"Q8WVN8\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 R1\",\"id\":\"P49427\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 R2\",\"id\":\"Q712K3\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 U\",\"id\":\"Q5VVX9\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 W\",\"id\":\"Q96B02\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 Z\",\"id\":\"Q9H832\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 1\",\"id\":\"Q13404\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 2\",\"id\":\"Q15819\"},{\"label\":\"Ubiquitin-like modifier-activating enzyme 1\",\"id\":\"P22314\"},{\"label\":\"Ubiquitin-like modifier-activating enzyme 5\",\"id\":\"Q9GZZ9\"},{\"label\":\"Ubiquitin-like modifier-activating enzyme 6\",\"id\":\"A0AVT1\"},{\"label\":\"Ubiquitin-like modifier-activating enzyme 7\",\"id\":\"P41226\"},{\"label\":\"Ubiquitin-like modifier-activating enzyme ATG7\",\"id\":\"O95352\"},{\"label\":\"Ubiquitin-protein ligase E3A\",\"id\":\"Q05086\"},{\"label\":\"Ubiquitin-protein ligase E3B\",\"id\":\"Q7Z3V4\"},{\"label\":\"Ubiquitin-protein 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cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta 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"gtc_id": "[\"\"]" }, { "pathway_label": "Histamine receptors", "protein_name": "[{\"label\":\"Histamine H1 receptor\",\"id\":\"P35367\"},{\"label\":\"Histamine H2 receptor\",\"id\":\"P25021\"},{\"label\":\"Histamine H3 receptor\",\"id\":\"Q9Y5N1\"},{\"label\":\"Histamine H4 receptor\",\"id\":\"Q9H3N8\"}]", "uniprot_id": "[\"P25021\",\"P35367\",\"Q9H3N8\",\"Q9Y5N1\"]", "gene_symbol": "[\"GPCR105\",\"GPCR97\",\"HRH1\",\"HRH2\",\"HRH3\",\"HRH4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "quizartinib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MHC class II antigen presentation", "protein_name": "[{\"label\":\"ADP-ribosylation factor 1\",\"id\":\"P84077\"},{\"label\":\"AP-1 complex subunit beta-1\",\"id\":\"Q10567\"},{\"label\":\"AP-1 complex subunit 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1\",\"id\":\"P53634\"},{\"label\":\"Dynactin subunit 1\",\"id\":\"Q14203\"},{\"label\":\"Dynactin subunit 2\",\"id\":\"Q13561\"},{\"label\":\"Dynactin subunit 3\",\"id\":\"O75935\"},{\"label\":\"Dynactin subunit 4\",\"id\":\"Q9UJW0\"},{\"label\":\"Dynactin subunit 5\",\"id\":\"Q9BTE1\"},{\"label\":\"Dynactin subunit 6\",\"id\":\"O00399\"},{\"label\":\"Dynamin-1\",\"id\":\"Q05193\"},{\"label\":\"Dynamin-2\",\"id\":\"P50570\"},{\"label\":\"Dynamin-3\",\"id\":\"Q9UQ16\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"Endophilin-A1\",\"id\":\"Q99962\"},{\"label\":\"F-actin-capping protein subunit alpha-1\",\"id\":\"P52907\"},{\"label\":\"F-actin-capping protein subunit alpha-2\",\"id\":\"P47755\"},{\"label\":\"F-actin-capping protein subunit alpha-3\",\"id\":\"Q96KX2\"},{\"label\":\"F-actin-capping protein subunit beta\",\"id\":\"P47756\"},{\"label\":\"Gamma-interferon-inducible lysosomal 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protein\",\"id\":\"Q92793\"},{\"label\":\"CREB-regulated transcription coactivator 1\",\"id\":\"Q6UUV9\"},{\"label\":\"CREB-regulated transcription coactivator 2\",\"id\":\"Q53ET0\"},{\"label\":\"CREB-regulated transcription coactivator 3\",\"id\":\"Q6UUV7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type IV\",\"id\":\"Q16566\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 9\",\"id\":\"Q3L8U1\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-2\",\"id\":\"P15336\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"DNA polymerase subunit gamma-2\",\"id\":\"Q9UHN1\"},{\"label\":\"DNA-directed RNA polymerase, mitochondrial\",\"id\":\"O00411\"},{\"label\":\"Dimethyladenosine transferase 1, mitochondrial\",\"id\":\"Q8WVM0\"},{\"label\":\"Dimethyladenosine transferase 2, mitochondrial\",\"id\":\"Q9H5Q4\"},{\"label\":\"F-box-like/WD repeat-containing protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Negative regulation of FGFR4 signaling", "protein_name": "[{\"label\":\"Beta-klotho\",\"id\":\"Q86Z14\"},{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 19\",\"id\":\"O95750\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 4\",\"id\":\"P22455\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O43320\",\"O76093\",\"O95750\",\"P05230\",\"P08620\",\"P09038\",\"P0CG47\",\"P0CG48\",\"P10767\",\"P22455\",\"P22681\",\"P27361\",\"P28482\",\"P31371\",\"P62979\",\"P62987\",\"Q06124\",\"Q86Z14\",\"Q8WU20\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": 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1\",\"id\":\"Q8IUC6\"},{\"label\":\"TIR domain-containing adapter molecule 2\",\"id\":\"Q86XR7\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00206\",\"O43187\",\"O43318\",\"P08571\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q15750\",\"Q86XR7\",\"Q8IUC6\",\"Q8N5C8\",\"Q9NYJ8\",\"Q9Y4K3\",\"Q9Y6Y9\"]", "gene_symbol": "[\"CD14\",\"ESOP1\",\"IRAK2\",\"KIAA0733\",\"LY96\",\"MAP3K7\",\"MAP3K7IP1\",\"MAP3K7IP2\",\"MAP3K7IP3\",\"MD2\",\"PRVTIRB\",\"RNF85\",\"RPS27A\",\"TAB1\",\"TAB2\",\"TAB3\",\"TAK1\",\"TICAM1\",\"TICAM2\",\"TIRAP3\",\"TIRP\",\"TLR4\",\"TRAF6\",\"TRAM\",\"TRIF\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "alpha-linolenic acid (ALA) metabolism", "protein_name": "[{\"label\":\"3-ketoacyl-CoA thiolase, peroxisomal\",\"id\":\"P09110\"},{\"label\":\"ATP-binding cassette sub-family D member 1\",\"id\":\"P33897\"},{\"label\":\"Acyl-CoA (8-3)-desaturase\",\"id\":\"O60427\"},{\"label\":\"Acyl-CoA 6-desaturase\",\"id\":\"O95864\"},{\"label\":\"Acyl-coenzyme A thioesterase 8\",\"id\":\"O14734\"},{\"label\":\"Long-chain-fatty-acid--CoA ligase 1\",\"id\":\"P33121\"},{\"label\":\"Peroxisomal multifunctional enzyme type 2\",\"id\":\"P51659\"},{\"label\":\"Sterol carrier protein 2\",\"id\":\"P22307\"},{\"label\":\"Very long chain fatty acid elongase 1\",\"id\":\"Q9BW60\"},{\"label\":\"Very long chain fatty acid elongase 2\",\"id\":\"Q9NXB9\"},{\"label\":\"Very long chain fatty acid elongase 3\",\"id\":\"Q9HB03\"},{\"label\":\"Very long chain fatty acid elongase 5\",\"id\":\"Q9NYP7\"}]", "uniprot_id": "[\"O14734\",\"O60427\",\"O95864\",\"P09110\",\"P22307\",\"P33121\",\"P33897\",\"P51659\",\"Q9BW60\",\"Q9HB03\",\"Q9NXB9\",\"Q9NYP7\"]", "gene_symbol": "[\"ABCD1\",\"ACAA\",\"ACAA1\",\"ACOT8\",\"ACSL1\",\"ACTEIII\",\"ALD\",\"CIG30\",\"EDH17B4\",\"ELG3\",\"ELOVL1\",\"ELOVL2\",\"ELOVL3\",\"ELOVL5\",\"FACL1\",\"FACL2\",\"FADS1\",\"FADS2\",\"FADSD5\",\"HSD17B4\",\"LACS\",\"LACS1\",\"LACS2\",\"PTE1\",\"PTHIO\",\"SCP2\",\"SDR8C1\",\"SSC1\",\"SSC2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCC8 can cause hypo- and hyper-glycemias", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 8\",\"id\":\"Q09428\"},{\"label\":\"ATP-sensitive inward rectifier potassium channel 11\",\"id\":\"Q14654\"}]", "uniprot_id": "[\"Q09428\",\"Q14654\"]", "gene_symbol": "[\"ABCC8\",\"HRINS\",\"KCNJ11\",\"SUR\",\"SUR1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ion homeostasis", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 9\",\"id\":\"O60706\"},{\"label\":\"ATP-sensitive inward rectifier potassium channel 11\",\"id\":\"Q14654\"},{\"label\":\"Aspartyl/asparaginyl beta-hydroxylase\",\"id\":\"Q12797\"},{\"label\":\"Calcium release-activated calcium channel protein 1\",\"id\":\"Q96D31\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Cardiac phospholamban\",\"id\":\"P26678\"},{\"label\":\"Chloride intracellular channel protein 2\",\"id\":\"O15247\"},{\"label\":\"FXYD domain-containing ion transport regulator 3\",\"id\":\"Q14802\"},{\"label\":\"FXYD domain-containing ion transport regulator 4\",\"id\":\"P59646\"},{\"label\":\"FXYD domain-containing ion transport regulator 6\",\"id\":\"Q9H0Q3\"},{\"label\":\"FXYD domain-containing ion transport 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"gtc_id": "[\"\"]" }, { "pathway_label": "FRS-mediated FGFR3 signaling", "protein_name": "[{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Fibroblast growth factor receptor substrate 3\",\"id\":\"O43559\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": 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4\",\"id\":\"Q9HCU8\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Protection of telomeres protein 1\",\"id\":\"Q9NUX5\"},{\"label\":\"RecQ-like DNA helicase BLM\",\"id\":\"P54132\"},{\"label\":\"TERF1-interacting nuclear factor 2\",\"id\":\"Q9BSI4\"},{\"label\":\"Telomeric repeat-binding factor 1\",\"id\":\"P54274\"},{\"label\":\"Telomeric repeat-binding factor 2-interacting protein 1\",\"id\":\"Q9NYB0\"},{\"label\":\"Telomeric repeat-binding factor 2\",\"id\":\"Q15554\"}]", "uniprot_id": "[\"P12004\",\"P18858\",\"P28340\",\"P49005\",\"P54132\",\"P54274\",\"Q14191\",\"Q15054\",\"Q15554\",\"Q96AP0\",\"Q9BSI4\",\"Q9HCU8\",\"Q9NUX5\",\"Q9NYB0\"]", "gene_symbol": 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mitochondrial\",\"id\":\"P36551\"},{\"label\":\"Porphobilinogen deaminase\",\"id\":\"P08397\"},{\"label\":\"Protoheme IX farnesyltransferase, mitochondrial\",\"id\":\"Q12887\"},{\"label\":\"Protoporphyrinogen oxidase\",\"id\":\"P50336\"},{\"label\":\"Uroporphyrinogen decarboxylase\",\"id\":\"P06132\"},{\"label\":\"Uroporphyrinogen-III synthase\",\"id\":\"P10746\"}]", "uniprot_id": "[\"P02768\",\"P06132\",\"P08397\",\"P10746\",\"P13196\",\"P13716\",\"P22557\",\"P22830\",\"P36551\",\"P50336\",\"Q12887\",\"Q7KZN9\",\"Q9UNQ0\"]", "gene_symbol": "[\"ABCG2\",\"ABCP\",\"ALAD\",\"ALAS1\",\"ALAS2\",\"ALAS3\",\"ALASE\",\"ALASH\",\"ALB\",\"ASB\",\"BCRP\",\"BCRP1\",\"COX10\",\"COX15\",\"CPO\",\"CPOX\",\"CPX\",\"FECH\",\"HMBS\",\"MXR\",\"PBGD\",\"PPOX\",\"UPS\",\"UROD\",\"UROS\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TWIK-related spinal cord K+ channel (TRESK)", "protein_name": "[{\"label\":\"Potassium channel subfamily K member 18\",\"id\":\"Q7Z418\"}]", "uniprot_id": "[\"Q7Z418\"]", "gene_symbol": "[\"KCNK18\",\"TRESK\",\"TRIK\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 1\",\"id\":\"Q96FA3\"},{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 2\",\"id\":\"Q9HAT8\"},{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 3\",\"id\":\"Q8N2H9\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 1\",\"id\":\"Q13404\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"P51617\",\"P61088\",\"Q13404\",\"Q8N2H9\",\"Q96FA3\",\"Q9HAT8\",\"Q9Y4K3\",\"Q9Y6K9\"]", "gene_symbol": "[\"BLU\",\"CHUK\",\"CROC1\",\"FIP3\",\"IKBKB\",\"IKBKG\",\"IKKA\",\"IKKB\",\"IRAK\",\"IRAK1\",\"NEMO\",\"PELI1\",\"PELI2\",\"PELI3\",\"PRISM\",\"RNF85\",\"TCF16\",\"TRAF6\",\"UBE2N\",\"UBE2V\",\"UBE2V1\",\"UEV1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of NFE2L2 gene expression", "protein_name": "[{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"},{\"label\":\"Transcription factor MafK\",\"id\":\"O60675\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": "[\"O60675\",\"P01106\",\"P19838\",\"P46531\",\"Q04206\",\"Q09472\",\"Q16236\",\"Q92793\"]", "gene_symbol": "[\"BHLHE39\",\"CBP\",\"CREBBP\",\"EP300\",\"MAFK\",\"MYC\",\"NFE2L2\",\"NFKB1\",\"NFKB3\",\"NOTCH1\",\"NRF2\",\"P300\",\"RELA\",\"TAN1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SHC1 events in EGFR signaling", "protein_name": "[{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Epigen\",\"id\":\"Q6UW88\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Protransforming growth factor alpha\",\"id\":\"P01135\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O14944\",\"P00533\",\"P01111\",\"P01112\",\"P01133\",\"P01135\",\"P15514\",\"P29353\",\"P35070\",\"Q07889\",\"Q6UW88\",\"Q99075\"]", "gene_symbol": "[\"AREG\",\"AREGB\",\"BTC\",\"DTR\",\"DTS\",\"EGF\",\"EGFR\",\"EPGN\",\"ERBB\",\"ERBB1\",\"EREG\",\"HBEGF\",\"HEGFL\",\"HER1\",\"HRAS\",\"HRAS1\",\"NRAS\",\"SDGF\",\"SHC\",\"SHC1\",\"SHCA\",\"SOS1\",\"TGFA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of PC", "protein_name": "[{\"label\":\"Acetylcholinesterase\",\"id\":\"P22303\"},{\"label\":\"Casein kinase II subunit alpha'\",\"id\":\"P19784\"},{\"label\":\"Casein kinase II subunit alpha\",\"id\":\"P68400\"},{\"label\":\"Casein kinase II subunit beta\",\"id\":\"P67870\"},{\"label\":\"Choline O-acetyltransferase\",\"id\":\"P28329\"},{\"label\":\"Choline kinase alpha\",\"id\":\"P35790\"},{\"label\":\"Choline transporter-like protein 1\",\"id\":\"Q8WWI5\"},{\"label\":\"Choline transporter-like protein 2\",\"id\":\"Q8IWA5\"},{\"label\":\"Choline transporter-like protein 3\",\"id\":\"Q8N4M1\"},{\"label\":\"Choline transporter-like protein 4\",\"id\":\"Q53GD3\"},{\"label\":\"Choline transporter-like protein 5\",\"id\":\"Q8NCS7\"},{\"label\":\"Choline-phosphate cytidylyltransferase A\",\"id\":\"P49585\"},{\"label\":\"Choline-phosphate cytidylyltransferase B\",\"id\":\"Q9Y5K3\"},{\"label\":\"Choline/ethanolamine kinase\",\"id\":\"Q9Y259\"},{\"label\":\"Choline/ethanolaminephosphotransferase 1\",\"id\":\"Q9Y6K0\"},{\"label\":\"Cholinephosphotransferase 1\",\"id\":\"Q8WUD6\"},{\"label\":\"Cholinesterase\",\"id\":\"P06276\"},{\"label\":\"Lysophosphatidylcholine acyltransferase 1\",\"id\":\"Q8NF37\"},{\"label\":\"Phosphatidate phosphatase LPIN1\",\"id\":\"Q14693\"},{\"label\":\"Phosphatidate phosphatase LPIN2\",\"id\":\"Q92539\"},{\"label\":\"Phosphatidate phosphatase LPIN3\",\"id\":\"Q9BQK8\"},{\"label\":\"Phosphatidylcholine transfer protein\",\"id\":\"Q9UKL6\"},{\"label\":\"Phosphatidylethanolamine N-methyltransferase\",\"id\":\"Q9UBM1\"},{\"label\":\"Phosphoethanolamine/phosphocholine phosphatase\",\"id\":\"Q8TCT1\"},{\"label\":\"Phospholipase ABHD3\",\"id\":\"Q8WU67\"},{\"label\":\"START domain-containing protein 10\",\"id\":\"Q9Y365\"},{\"label\":\"Sodium-dependent lysophosphatidylcholine symporter 1\",\"id\":\"Q8NA29\"},{\"label\":\"StAR-related lipid transfer protein 7, mitochondrial\",\"id\":\"Q9NQZ5\"}]", "uniprot_id": "[\"P06276\",\"P19784\",\"P22303\",\"P28329\",\"P35790\",\"P49585\",\"P67870\",\"P68400\",\"Q14693\",\"Q53GD3\",\"Q8IWA5\",\"Q8N4M1\",\"Q8NA29\",\"Q8NCS7\",\"Q8NF37\",\"Q8TCT1\",\"Q8WU67\",\"Q8WUD6\",\"Q8WWI5\",\"Q92539\",\"Q9BQK8\",\"Q9NQZ5\",\"Q9UBM1\",\"Q9UKL6\",\"Q9Y259\",\"Q9Y365\",\"Q9Y5K3\",\"Q9Y6K0\"]", "gene_symbol": 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UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"}]", "uniprot_id": "[\"P49840\",\"P49841\",\"P59595\",\"P63165\",\"P63279\",\"Q2NL67\",\"Q460N5\",\"Q53GL7\",\"Q8IXQ6\",\"Q8N3A8\",\"Q8N5Y8\",\"Q9UKK3\"]", "gene_symbol": "[\"ADPRTL1\",\"ARTD15\",\"BAL\",\"BAL1\",\"BAL2\",\"C15orf30\",\"GSK3A\",\"GSK3B\",\"KIAA0177\",\"KIAA1268\",\"N\",\"PARP10\",\"PARP14\",\"PARP16\",\"PARP4\",\"PARP6\",\"PARP8\",\"PARP9\",\"PARPL\",\"SMT3C\",\"SMT3H3\",\"SUMO1\",\"UBC9\",\"UBCE9\",\"UBE2I\",\"UBL1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Folding of actin by CCT/TriC", "protein_name": "[{\"label\":\"Actin, cytoplasmic 1\",\"id\":\"P60709\"},{\"label\":\"T-complex protein 1 subunit alpha\",\"id\":\"P17987\"},{\"label\":\"T-complex protein 1 subunit beta\",\"id\":\"P78371\"},{\"label\":\"T-complex protein 1 subunit delta\",\"id\":\"P50991\"},{\"label\":\"T-complex protein 1 subunit epsilon\",\"id\":\"P48643\"},{\"label\":\"T-complex protein 1 subunit eta\",\"id\":\"Q99832\"},{\"label\":\"T-complex protein 1 subunit gamma\",\"id\":\"P49368\"},{\"label\":\"T-complex protein 1 subunit theta\",\"id\":\"P50990\"},{\"label\":\"T-complex protein 1 subunit zeta-2\",\"id\":\"Q92526\"},{\"label\":\"T-complex protein 1 subunit zeta\",\"id\":\"P40227\"}]", "uniprot_id": "[\"P17987\",\"P40227\",\"P48643\",\"P49368\",\"P50990\",\"P50991\",\"P60709\",\"P78371\",\"Q92526\",\"Q99832\"]", "gene_symbol": "[\"99D8.1\",\"ACTB\",\"C21orf112\",\"CCT1\",\"CCT2\",\"CCT3\",\"CCT4\",\"CCT5\",\"CCT6\",\"CCT6A\",\"CCT6B\",\"CCT7\",\"CCT8\",\"CCTA\",\"CCTB\",\"CCTD\",\"CCTE\",\"CCTG\",\"CCTH\",\"CCTQ\",\"CCTZ\",\"KIAA0002\",\"KIAA0098\",\"NIP7-1\",\"SRB\",\"TCP1\",\"TRIC5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate", "protein_name": "[{\"label\":\"Isocitrate dehydrogenase [NADP] cytoplasmic\",\"id\":\"O75874\"}]", "uniprot_id": "[\"O75874\"]", "gene_symbol": "[\"IDH1\",\"PICD\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal", "protein_name": "[{\"label\":\"Aurora kinase B\",\"id\":\"Q96GD4\"},{\"label\":\"B9 domain-containing protein 2\",\"id\":\"Q9BPU9\"},{\"label\":\"Baculoviral IAP repeat-containing protein 5\",\"id\":\"O15392\"},{\"label\":\"Borealin\",\"id\":\"Q53HL2\"},{\"label\":\"CAP-Gly domain-containing linker protein 1\",\"id\":\"P30622\"},{\"label\":\"CLIP-associating protein 1\",\"id\":\"Q7Z460\"},{\"label\":\"CLIP-associating protein 2\",\"id\":\"O75122\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Centromere protein C\",\"id\":\"Q03188\"},{\"label\":\"Centromere protein F\",\"id\":\"P49454\"},{\"label\":\"Centromere protein H\",\"id\":\"Q9H3R5\"},{\"label\":\"Centromere protein I\",\"id\":\"Q92674\"},{\"label\":\"Centromere protein K\",\"id\":\"Q9BS16\"},{\"label\":\"Centromere protein L\",\"id\":\"Q8N0S6\"},{\"label\":\"Centromere protein M\",\"id\":\"Q9NSP4\"},{\"label\":\"Centromere protein N\",\"id\":\"Q96H22\"},{\"label\":\"Centromere protein O\",\"id\":\"Q9BU64\"},{\"label\":\"Centromere protein P\",\"id\":\"Q6IPU0\"},{\"label\":\"Centromere protein Q\",\"id\":\"Q7L2Z9\"},{\"label\":\"Centromere protein R\",\"id\":\"Q13352\"},{\"label\":\"Centromere protein S\",\"id\":\"Q8N2Z9\"},{\"label\":\"Centromere protein T\",\"id\":\"Q96BT3\"},{\"label\":\"Centromere protein U\",\"id\":\"Q71F23\"},{\"label\":\"Centromere-associated protein E\",\"id\":\"Q02224\"},{\"label\":\"Centromere/kinetochore protein zw10 homolog\",\"id\":\"O43264\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 1\",\"id\":\"O14576\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 2\",\"id\":\"O43237\"},{\"label\":\"Cytoskeleton-associated protein 5\",\"id\":\"Q14008\"},{\"label\":\"DNA excision repair protein ERCC-6-like\",\"id\":\"Q2NKX8\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"Histone H3-like centromeric protein A\",\"id\":\"P49450\"},{\"label\":\"Inner centromere protein\",\"id\":\"Q9NQS7\"},{\"label\":\"Kinesin-like protein KIF18A\",\"id\":\"Q8NI77\"},{\"label\":\"Kinesin-like protein KIF2A\",\"id\":\"O00139\"},{\"label\":\"Kinesin-like protein KIF2B\",\"id\":\"Q8N4N8\"},{\"label\":\"Kinesin-like protein KIF2C\",\"id\":\"Q99661\"},{\"label\":\"Kinetochore protein NDC80 homolog\",\"id\":\"O14777\"},{\"label\":\"Kinetochore protein Nuf2\",\"id\":\"Q9BZD4\"},{\"label\":\"Kinetochore protein Spc24\",\"id\":\"Q8NBT2\"},{\"label\":\"Kinetochore protein Spc25\",\"id\":\"Q9HBM1\"},{\"label\":\"Kinetochore scaffold 1\",\"id\":\"Q8NG31\"},{\"label\":\"Kinetochore-associated protein 1\",\"id\":\"P50748\"},{\"label\":\"Kinetochore-associated protein DSN1 homolog\",\"id\":\"Q9H410\"},{\"label\":\"Kinetochore-associated protein NSL1 homolog\",\"id\":\"Q96IY1\"},{\"label\":\"Microtubule-associated protein RP/EB family member 1\",\"id\":\"Q15691\"},{\"label\":\"Mitotic checkpoint protein BUB3\",\"id\":\"O43684\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta\",\"id\":\"O60566\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1\",\"id\":\"O43683\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD1\",\"id\":\"Q9Y6D9\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2A\",\"id\":\"Q13257\"},{\"label\":\"Nuclear distribution protein nudE homolog 1\",\"id\":\"Q9NXR1\"},{\"label\":\"Nuclear distribution protein nudE-like 1\",\"id\":\"Q9GZM8\"},{\"label\":\"Nuclear migration protein nudC\",\"id\":\"Q9Y266\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit beta\",\"id\":\"P43034\"},{\"label\":\"Polyamine-modulated factor 1\",\"id\":\"Q6P1K2\"},{\"label\":\"Protein ELYS\",\"id\":\"Q8WYP5\"},{\"label\":\"Protein MIS12 homolog\",\"id\":\"Q9H081\"},{\"label\":\"Protein RCC2\",\"id\":\"Q9P258\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Protein Spindly\",\"id\":\"Q96EA4\"},{\"label\":\"Protein zwilch homolog\",\"id\":\"Q9H900\"},{\"label\":\"Ran GTPase-activating protein 1\",\"id\":\"P46060\"},{\"label\":\"SKA complex subunit 1\",\"id\":\"Q96BD8\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"},{\"label\":\"Serine/threonine-protein kinase TAO1\",\"id\":\"Q7L7X3\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-gamma catalytic subunit\",\"id\":\"P36873\"},{\"label\":\"Shugoshin 1\",\"id\":\"Q5FBB7\"},{\"label\":\"Shugoshin 2\",\"id\":\"Q562F6\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Spindle and kinetochore-associated protein 2\",\"id\":\"Q8WVK7\"},{\"label\":\"ZW10 interactor\",\"id\":\"O95229\"}]", "uniprot_id": 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"gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Clearance of seratonin", "protein_name": "[{\"label\":\"Sodium-dependent serotonin transporter\",\"id\":\"P31645\"}]", "uniprot_id": "[\"P31645\"]", "gene_symbol": "[\"HTT\",\"SERT\",\"SLC6A4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CTNNB1 S33 mutants aren't phosphorylated", "protein_name": "[{\"label\":\"APC membrane recruitment protein 1\",\"id\":\"Q5JTC6\"},{\"label\":\"Adenomatous polyposis coli protein\",\"id\":\"P25054\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Casein kinase I isoform alpha\",\"id\":\"P48729\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O15169\",\"P25054\",\"P30153\",\"P30154\",\"P35222\",\"P48729\",\"P49841\",\"P62714\",\"P67775\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\"]", "gene_symbol": "[\"AMER1\",\"APC\",\"AXIN\",\"AXIN1\",\"CSNK1A1\",\"CTNNB\",\"CTNNB1\",\"DP2.5\",\"FAM123B\",\"GSK3B\",\"KIAA0044\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"WTX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mitochondrial protein import", "protein_name": "[{\"label\":\"4-hydroxybenzoate polyprenyltransferase, mitochondrial\",\"id\":\"Q96H96\"},{\"label\":\"60 kDa heat shock protein, mitochondrial\",\"id\":\"P10809\"},{\"label\":\"ADP/ATP translocase 1\",\"id\":\"P12235\"},{\"label\":\"ADP/ATP translocase 3\",\"id\":\"P12236\"},{\"label\":\"ATP synthase F(0) complex subunit C1, mitochondrial\",\"id\":\"P05496\"},{\"label\":\"ATP synthase subunit alpha, mitochondrial\",\"id\":\"P25705\"},{\"label\":\"ATP synthase subunit beta, mitochondrial\",\"id\":\"P06576\"},{\"label\":\"Aconitate hydratase, mitochondrial\",\"id\":\"Q99798\"},{\"label\":\"COX assembly mitochondrial protein 2 homolog\",\"id\":\"Q9NRP2\"},{\"label\":\"Citrate synthase, mitochondrial\",\"id\":\"O75390\"},{\"label\":\"Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial\",\"id\":\"Q8WYQ3\"},{\"label\":\"Coiled-coil-helix-coiled-coil-helix domain-containing protein 2\",\"id\":\"Q9Y6H1\"},{\"label\":\"Coiled-coil-helix-coiled-coil-helix domain-containing protein 5\",\"id\":\"Q9BSY4\"},{\"label\":\"Coiled-coil-helix-coiled-coil-helix domain-containing protein 7\",\"id\":\"Q9BUK0\"},{\"label\":\"Cx9C motif-containing protein 4\",\"id\":\"P56277\"},{\"label\":\"Cytochrome c oxidase assembly factor 4 homolog, mitochondrial\",\"id\":\"Q9NYJ1\"},{\"label\":\"Cytochrome c oxidase assembly factor 6 homolog\",\"id\":\"Q5JTJ3\"},{\"label\":\"Cytochrome c oxidase assembly protein COX19\",\"id\":\"Q49B96\"},{\"label\":\"Cytochrome c oxidase copper chaperone\",\"id\":\"Q14061\"},{\"label\":\"Cytochrome c1, heme protein, mitochondrial\",\"id\":\"P08574\"},{\"label\":\"Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial\",\"id\":\"O75746\"},{\"label\":\"Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial\",\"id\":\"Q9UJS0\"},{\"label\":\"FAD-linked sulfhydryl oxidase ALR\",\"id\":\"P55789\"},{\"label\":\"Frataxin, mitochondrial\",\"id\":\"Q16595\"},{\"label\":\"GrpE protein homolog 1, mitochondrial\",\"id\":\"Q9HAV7\"},{\"label\":\"GrpE protein homolog 2, mitochondrial\",\"id\":\"Q8TAA5\"},{\"label\":\"Iron-sulfur cluster co-chaperone protein HscB\",\"id\":\"Q8IWL3\"},{\"label\":\"Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial\",\"id\":\"P51553\"},{\"label\":\"MICOS complex subunit MIC19\",\"id\":\"Q9NX63\"},{\"label\":\"Metaxin-1\",\"id\":\"Q13505\"},{\"label\":\"Metaxin-2\",\"id\":\"O75431\"},{\"label\":\"Mitochondrial chaperone BCS1\",\"id\":\"Q9Y276\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit TIM14\",\"id\":\"Q96DA6\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit TIM16\",\"id\":\"Q9Y3D7\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit TIM44\",\"id\":\"O43615\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit TIM50\",\"id\":\"Q3ZCQ8\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim10 B\",\"id\":\"Q9Y5J6\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim10\",\"id\":\"P62072\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim13\",\"id\":\"Q9Y5L4\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim17-A\",\"id\":\"Q99595\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim17-B\",\"id\":\"O60830\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim21\",\"id\":\"Q9BVV7\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim22\",\"id\":\"Q9Y584\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim23\",\"id\":\"O14925\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim8 A\",\"id\":\"O60220\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim8 B\",\"id\":\"Q9Y5J9\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim9\",\"id\":\"Q9Y5J7\"},{\"label\":\"Mitochondrial import receptor subunit TOM20 homolog\",\"id\":\"Q15388\"},{\"label\":\"Mitochondrial import receptor subunit TOM22 homolog\",\"id\":\"Q9NS69\"},{\"label\":\"Mitochondrial import receptor subunit TOM40 homolog\",\"id\":\"O96008\"},{\"label\":\"Mitochondrial import receptor subunit TOM5 homolog\",\"id\":\"Q8N4H5\"},{\"label\":\"Mitochondrial import receptor subunit TOM6 homolog\",\"id\":\"Q96B49\"},{\"label\":\"Mitochondrial import receptor subunit TOM7 homolog\",\"id\":\"Q9P0U1\"},{\"label\":\"Mitochondrial import receptor subunit TOM70\",\"id\":\"O94826\"},{\"label\":\"Mitochondrial intermembrane space import and assembly protein 40\",\"id\":\"Q8N4Q1\"},{\"label\":\"Mitochondrial-processing peptidase subunit alpha\",\"id\":\"Q10713\"},{\"label\":\"Mitochondrial-processing peptidase subunit beta\",\"id\":\"O75439\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial\",\"id\":\"O95169\"},{\"label\":\"Non-selective voltage-gated ion channel VDAC1\",\"id\":\"P21796\"},{\"label\":\"Ornithine transcarbamylase, mitochondrial\",\"id\":\"P00480\"},{\"label\":\"Presequence protease, mitochondrial\",\"id\":\"Q5JRX3\"},{\"label\":\"Probable D-lactate dehydrogenase, mitochondrial\",\"id\":\"Q86WU2\"},{\"label\":\"Sorting and assembly machinery component 50 homolog\",\"id\":\"Q9Y512\"},{\"label\":\"Stress-70 protein, mitochondrial\",\"id\":\"P38646\"},{\"label\":\"Tafazzin\",\"id\":\"Q16635\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria", "protein_name": "[{\"label\":\"Inactive sodium-dependent neutral amino acid transporter B(0)AT3\",\"id\":\"Q96N87\"}]", "uniprot_id": "[\"Q96N87\"]", "gene_symbol": "[\"B0AT3\",\"SLC6A18\",\"XTRP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Termination of translesion DNA synthesis", "protein_name": "[{\"label\":\"DNA polymerase delta catalytic subunit\",\"id\":\"P28340\"},{\"label\":\"DNA polymerase delta subunit 2\",\"id\":\"P49005\"},{\"label\":\"DNA polymerase delta subunit 3\",\"id\":\"Q15054\"},{\"label\":\"DNA polymerase delta subunit 4\",\"id\":\"Q9HCU8\"},{\"label\":\"DNA polymerase epsilon catalytic subunit A\",\"id\":\"Q07864\"},{\"label\":\"DNA polymerase epsilon subunit 2\",\"id\":\"P56282\"},{\"label\":\"DNA polymerase epsilon subunit 3\",\"id\":\"Q9NRF9\"},{\"label\":\"DNA polymerase epsilon subunit 4\",\"id\":\"Q9NR33\"},{\"label\":\"DNA 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"gtc_id": "[\"\"]" }, { "pathway_label": "Mitochondrial calcium ion transport", "protein_name": "[{\"label\":\"A-kinase anchor protein 1, mitochondrial\",\"id\":\"Q92667\"},{\"label\":\"Calcium uniporter protein, mitochondrial\",\"id\":\"Q8NE86\"},{\"label\":\"Calcium uniporter regulatory subunit MCUb, mitochondrial\",\"id\":\"Q9NWR8\"},{\"label\":\"Calcium uptake protein 1, mitochondrial\",\"id\":\"Q9BPX6\"},{\"label\":\"Calcium uptake protein 2, mitochondrial\",\"id\":\"Q8IYU8\"},{\"label\":\"Calcium uptake protein 3, mitochondrial\",\"id\":\"Q86XE3\"},{\"label\":\"Essential MCU regulator, mitochondrial\",\"id\":\"Q9H4I9\"},{\"label\":\"Mitochondrial proton/calcium exchanger protein\",\"id\":\"O95202\"},{\"label\":\"Mitochondrial sodium/calcium exchanger protein\",\"id\":\"Q6J4K2\"},{\"label\":\"Non-selective voltage-gated ion channel VDAC1\",\"id\":\"P21796\"},{\"label\":\"Sodium/calcium exchanger 3\",\"id\":\"P57103\"},{\"label\":\"Voltage-dependent anion-selective channel protein 2\",\"id\":\"P45880\"},{\"label\":\"Voltage-dependent anion-selective channel protein 3\",\"id\":\"Q9Y277\"}]", "uniprot_id": "[\"O95202\",\"P21796\",\"P45880\",\"P57103\",\"Q6J4K2\",\"Q86XE3\",\"Q8IYU8\",\"Q8NE86\",\"Q92667\",\"Q9BPX6\",\"Q9H4I9\",\"Q9NWR8\",\"Q9Y277\"]", "gene_symbol": "[\"AKAP1\",\"AKAP149\",\"C10orf42\",\"C22orf32\",\"CALC\",\"CBARA1\",\"CCDC109A\",\"CCDC109B\",\"EFHA1\",\"EFHA2\",\"EMRE\",\"LETM1\",\"MCU\",\"MCUB\",\"MICU1\",\"MICU2\",\"MICU3\",\"NCKX6\",\"NCLX\",\"NCX3\",\"PRKA1\",\"SLC24A6\",\"SLC8A3\",\"SLC8B1\",\"SMDT1\",\"VDAC\",\"VDAC1\",\"VDAC2\",\"VDAC3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Hypusinylation", "protein_name": "[{\"label\":\"Deoxyhypusine hydroxylase\",\"id\":\"Q9BU89\"},{\"label\":\"Deoxyhypusine synthase\",\"id\":\"P49366\"},{\"label\":\"Eukaryotic translation initiation factor 5A-1\",\"id\":\"P63241\"},{\"label\":\"Eukaryotic translation initiation factor 5A-2\",\"id\":\"Q9GZV4\"}]", "uniprot_id": 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"pathway_label": "YAP1- and WWTR1 (TAZ)-stimulated gene expression", "protein_name": "[{\"label\":\"CCN family member 2\",\"id\":\"P29279\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Homeobox protein Nkx-2.5\",\"id\":\"P52952\"},{\"label\":\"Homeodomain-interacting protein kinase 1\",\"id\":\"Q86Z02\"},{\"label\":\"Homeodomain-interacting protein kinase 2\",\"id\":\"Q9H2X6\"},{\"label\":\"Natriuretic peptides A\",\"id\":\"P01160\"},{\"label\":\"T-box transcription factor TBX5\",\"id\":\"Q99593\"},{\"label\":\"Transcription factor GATA-4\",\"id\":\"P43694\"},{\"label\":\"Transcriptional coactivator YAP1\",\"id\":\"P46937\"},{\"label\":\"Transcriptional enhancer factor TEF-1\",\"id\":\"P28347\"},{\"label\":\"Transcriptional enhancer factor TEF-3\",\"id\":\"Q15561\"},{\"label\":\"Transcriptional enhancer factor TEF-4\",\"id\":\"Q15562\"},{\"label\":\"Transcriptional enhancer factor TEF-5\",\"id\":\"Q99594\"},{\"label\":\"WW domain-containing transcription regulator protein 1\",\"id\":\"Q9GZV5\"}]", "uniprot_id": "[\"P01160\",\"P28347\",\"P29279\",\"P43694\",\"P46937\",\"P52952\",\"Q15561\",\"Q15562\",\"Q86Z02\",\"Q92831\",\"Q99593\",\"Q99594\",\"Q9GZV5\",\"Q9H2X6\"]", "gene_symbol": "[\"ANP\",\"CCN2\",\"CSX\",\"CTGF\",\"GATA4\",\"HCS24\",\"HIPK1\",\"HIPK2\",\"IGFBP8\",\"KAT2B\",\"KIAA0630\",\"MYAK\",\"NBAK2\",\"NKX2-5\",\"NKX2.5\",\"NKX2E\",\"NPPA\",\"PCAF\",\"PND\",\"RTEF1\",\"TAZ\",\"TBX5\",\"TCF13\",\"TCF13L1\",\"TEAD1\",\"TEAD2\",\"TEAD3\",\"TEAD4\",\"TEAD5\",\"TEF1\",\"TEF3\",\"TEF4\",\"TEF5\",\"WWTR1\",\"YAP1\",\"YAP65\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FCERI mediated NF-kB activation", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"3-phosphoinositide-dependent protein kinase 1\",\"id\":\"O15530\"},{\"label\":\"B-cell lymphoma/leukemia 10\",\"id\":\"O95999\"},{\"label\":\"Caspase recruitment domain-containing protein 11\",\"id\":\"Q9BXL7\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"F-box/WD repeat-containing protein 11\",\"id\":\"Q9UKB1\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant epsilon\",\"id\":\"P01854\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 3-20\",\"id\":\"P01619\"},{\"label\":\"Immunoglobulin kappa variable 3D-20\",\"id\":\"A0A0C4DH25\"},{\"label\":\"Immunoglobulin kappa variable 4-1\",\"id\":\"P06312\"},{\"label\":\"Immunoglobulin kappa variable 5-2\",\"id\":\"P06315\"},{\"label\":\"Immunoglobulin lambda constant 1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 3\",\"id\":\"P0DOY3\"},{\"label\":\"Immunoglobulin lambda constant 6\",\"id\":\"P0CF74\"},{\"label\":\"Immunoglobulin lambda constant 7\",\"id\":\"A0M8Q6\"},{\"label\":\"Immunoglobulin lambda variable 1-40\",\"id\":\"P01703\"},{\"label\":\"Immunoglobulin lambda variable 1-44\",\"id\":\"P01699\"},{\"label\":\"Immunoglobulin lambda variable 1-47\",\"id\":\"P01700\"},{\"label\":\"Immunoglobulin lambda variable 1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 2-8\",\"id\":\"P01709\"},{\"label\":\"Immunoglobulin lambda variable 3-19\",\"id\":\"P01714\"},{\"label\":\"Immunoglobulin lambda variable 3-1\",\"id\":\"P01715\"},{\"label\":\"Immunoglobulin lambda variable 3-21\",\"id\":\"P80748\"},{\"label\":\"Immunoglobulin lambda variable 3-25\",\"id\":\"P01717\"},{\"label\":\"Immunoglobulin lambda variable 3-27\",\"id\":\"P01718\"},{\"label\":\"Immunoglobulin lambda variable 6-57\",\"id\":\"P01721\"},{\"label\":\"Immunoglobulin lambda variable 7-43\",\"id\":\"P04211\"},{\"label\":\"Immunolglobulin kappa light chain variable region L22 (Fragment)\",\"id\":\"A2NXD2\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit 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type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Protein kinase C theta type\",\"id\":\"Q04759\"},{\"label\":\"RAS guanyl-releasing protein 1\",\"id\":\"O95267\"},{\"label\":\"RAS guanyl-releasing protein 2\",\"id\":\"Q7LDG7\"},{\"label\":\"RAS guanyl-releasing protein 4\",\"id\":\"Q8TDF6\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 1\",\"id\":\"Q15750\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2\",\"id\":\"Q9NYJ8\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 3\",\"id\":\"Q8N5C8\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"UGa8H (Fragment)\",\"id\":\"A2KUC3\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D2\",\"id\":\"P62837\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 R1\",\"id\":\"P49427\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 1\",\"id\":\"Q13404\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"V1-11 protein (Fragment)\",\"id\":\"Q5NV67\"},{\"label\":\"V1-13 protein (Fragment)\",\"id\":\"Q5NV69\"},{\"label\":\"V1-16 protein (Fragment)\",\"id\":\"Q5NV81\"},{\"label\":\"V1-20 protein (Fragment)\",\"id\":\"Q5NV86\"},{\"label\":\"V1-3 protein (Fragment)\",\"id\":\"Q5NV84\"},{\"label\":\"V1-5 protein (Fragment)\",\"id\":\"Q5NV65\"},{\"label\":\"V1-7 protein (Fragment)\",\"id\":\"Q5NV89\"},{\"label\":\"V1-9 protein (Fragment)\",\"id\":\"Q5NV66\"},{\"label\":\"V2-11 protein (Fragment)\",\"id\":\"Q5NV64\"},{\"label\":\"V2-15 protein (Fragment)\",\"id\":\"Q5NV75\"},{\"label\":\"V2-17 protein (Fragment)\",\"id\":\"Q5NV90\"},{\"label\":\"V2-19 protein (Fragment)\",\"id\":\"Q5NV91\"},{\"label\":\"V2-8 protein (Fragment)\",\"id\":\"Q5NV85\"},{\"label\":\"V3-2 protein (Fragment)\",\"id\":\"Q5NV80\"},{\"label\":\"V3-3 protein (Fragment)\",\"id\":\"Q5NV83\"},{\"label\":\"V3-4 protein (Fragment)\",\"id\":\"Q5NV62\"},{\"label\":\"V4-1 protein (Fragment)\",\"id\":\"Q5NV68\"},{\"label\":\"V4-2 protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Cyclin A:Cdk2-associated events at S phase entry", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"CDK5 and ABL1 enzyme substrate 1\",\"id\":\"Q8TDN4\"},{\"label\":\"Cyclin-A1\",\"id\":\"P78396\"},{\"label\":\"Cyclin-A2\",\"id\":\"P20248\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"M-phase inducer phosphatase 1\",\"id\":\"P30304\"},{\"label\":\"M-phase inducer phosphatase 2\",\"id\":\"P30305\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Protein lin-37 homolog\",\"id\":\"Q96GY3\"},{\"label\":\"Protein lin-52 homolog\",\"id\":\"Q52LA3\"},{\"label\":\"Protein lin-54 homolog\",\"id\":\"Q6MZP7\"},{\"label\":\"Protein lin-9 homolog\",\"id\":\"Q5TKA1\"},{\"label\":\"Protein max\",\"id\":\"P61244\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Retinoblastoma-like protein 2\",\"id\":\"Q08999\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Transcription factor E2F4\",\"id\":\"Q16254\"},{\"label\":\"Transcription factor E2F5\",\"id\":\"Q15329\"},{\"label\":\"Wee1-like protein kinase\",\"id\":\"P30291\"}]", "uniprot_id": "[\"P01106\",\"P06400\",\"P20248\",\"P24941\",\"P30291\",\"P30304\",\"P30305\",\"P31749\",\"P31751\",\"P38936\",\"P46527\",\"P50613\",\"P51946\",\"P51948\",\"P61244\",\"P78396\",\"Q01094\",\"Q08999\",\"Q09028\",\"Q14186\",\"Q14188\",\"Q15329\",\"Q16254\",\"Q52LA3\",\"Q5TKA1\",\"Q6MZP7\",\"Q8TDN4\",\"Q96GY3\",\"Q9UM11\",\"Q9Y243\"]", "gene_symbol": 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1\",\"id\":\"P09467\"},{\"label\":\"Fructose-1,6-bisphosphatase isozyme 2\",\"id\":\"O00757\"},{\"label\":\"Fructose-bisphosphate aldolase A\",\"id\":\"P04075\"},{\"label\":\"Fructose-bisphosphate aldolase B\",\"id\":\"P05062\"},{\"label\":\"Fructose-bisphosphate aldolase C\",\"id\":\"P09972\"},{\"label\":\"Gamma-enolase\",\"id\":\"P09104\"},{\"label\":\"Glucose-6-phosphatase 2\",\"id\":\"Q9NQR9\"},{\"label\":\"Glucose-6-phosphatase 3\",\"id\":\"Q9BUM1\"},{\"label\":\"Glucose-6-phosphatase catalytic subunit 1\",\"id\":\"P35575\"},{\"label\":\"Glucose-6-phosphate exchanger SLC37A1\",\"id\":\"P57057\"},{\"label\":\"Glucose-6-phosphate exchanger SLC37A4\",\"id\":\"O43826\"},{\"label\":\"Glucose-6-phosphate isomerase\",\"id\":\"P06744\"},{\"label\":\"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific\",\"id\":\"O14556\"},{\"label\":\"Glyceraldehyde-3-phosphate dehydrogenase\",\"id\":\"P04406\"},{\"label\":\"Phosphoenolpyruvate carboxykinase [GTP], mitochondrial\",\"id\":\"Q16822\"},{\"label\":\"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]\",\"id\":\"P35558\"},{\"label\":\"Phosphoglycerate kinase 1\",\"id\":\"P00558\"},{\"label\":\"Phosphoglycerate kinase 2\",\"id\":\"P07205\"},{\"label\":\"Phosphoglycerate mutase 1\",\"id\":\"P18669\"},{\"label\":\"Phosphoglycerate mutase 2\",\"id\":\"P15259\"},{\"label\":\"Pyruvate carboxylase, mitochondrial\",\"id\":\"P11498\"},{\"label\":\"Triosephosphate isomerase\",\"id\":\"P60174\"}]", "uniprot_id": "[\"A6NNW6\",\"O00757\",\"O14556\",\"O43826\",\"P00558\",\"P04075\",\"P04406\",\"P05062\",\"P06733\",\"P06744\",\"P07205\",\"P09104\",\"P09467\",\"P09972\",\"P11498\",\"P13929\",\"P15259\",\"P18669\",\"P35558\",\"P35575\",\"P57057\",\"P60174\",\"Q16822\",\"Q9BUM1\",\"Q9NQR9\"]", "gene_symbol": 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mitochondrial\",\"id\":\"P36957\"},{\"label\":\"Glycine cleavage system H protein, mitochondrial\",\"id\":\"P23434\"},{\"label\":\"Glycine dehydrogenase (decarboxylating), mitochondrial\",\"id\":\"P23378\"}]", "uniprot_id": "[\"P09622\",\"P23378\",\"P23434\",\"P36957\",\"P48728\",\"P82909\",\"Q02218\"]", "gene_symbol": "[\"AMT\",\"DLD\",\"DLST\",\"DLTS\",\"GCSH\",\"GCSL\",\"GCSP\",\"GCST\",\"GLDC\",\"KGD4\",\"LAD\",\"MRPS36\",\"OGDH\",\"PHE3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "sorafenib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Glycosphingolipid catabolism", "protein_name": "[{\"label\":\"Acid ceramidase\",\"id\":\"Q13510\"},{\"label\":\"Alpha-galactosidase A\",\"id\":\"P06280\"},{\"label\":\"Arylsulfatase A\",\"id\":\"P15289\"},{\"label\":\"Arylsulfatase B\",\"id\":\"P15848\"},{\"label\":\"Arylsulfatase D\",\"id\":\"P51689\"},{\"label\":\"Arylsulfatase F\",\"id\":\"P54793\"},{\"label\":\"Arylsulfatase G\",\"id\":\"Q96EG1\"},{\"label\":\"Arylsulfatase H\",\"id\":\"Q5FYA8\"},{\"label\":\"Arylsulfatase I\",\"id\":\"Q5FYB1\"},{\"label\":\"Arylsulfatase J\",\"id\":\"Q5FYB0\"},{\"label\":\"Arylsulfatase K\",\"id\":\"Q6UWY0\"},{\"label\":\"Arylsulfatase L\",\"id\":\"P51690\"},{\"label\":\"Beta-galactosidase-1-like protein 2\",\"id\":\"Q8IW92\"},{\"label\":\"Beta-galactosidase-1-like protein 3\",\"id\":\"Q8NCI6\"},{\"label\":\"Beta-galactosidase-1-like protein\",\"id\":\"Q6UWU2\"},{\"label\":\"Beta-galactosidase\",\"id\":\"P16278\"},{\"label\":\"Beta-hexosaminidase subunit alpha\",\"id\":\"P06865\"},{\"label\":\"Beta-hexosaminidase subunit beta\",\"id\":\"P07686\"},{\"label\":\"Cation-dependent mannose-6-phosphate receptor\",\"id\":\"P20645\"},{\"label\":\"Cytosolic beta-glucosidase\",\"id\":\"Q9H227\"},{\"label\":\"Ectonucleotide pyrophosphatase/phosphodiesterase family member 7\",\"id\":\"Q6UWV6\"},{\"label\":\"Formylglycine-generating enzyme\",\"id\":\"Q8NBK3\"},{\"label\":\"Galactocerebrosidase\",\"id\":\"P54803\"},{\"label\":\"Ganglioside GM2 activator\",\"id\":\"P17900\"},{\"label\":\"Inactive C-alpha-formylglycine-generating enzyme 2\",\"id\":\"Q8NBJ7\"},{\"label\":\"Lysosomal acid glucosylceramidase\",\"id\":\"P04062\"},{\"label\":\"Lysosomal protective protein\",\"id\":\"P10619\"},{\"label\":\"Neutral ceramidase\",\"id\":\"Q9NR71\"},{\"label\":\"Non-lysosomal glucosylceramidase\",\"id\":\"Q9HCG7\"},{\"label\":\"Prosaposin\",\"id\":\"P07602\"},{\"label\":\"Sialidase-1\",\"id\":\"Q99519\"},{\"label\":\"Sialidase-2\",\"id\":\"Q9Y3R4\"},{\"label\":\"Sialidase-3\",\"id\":\"Q9UQ49\"},{\"label\":\"Sphingomyelin phosphodiesterase 2\",\"id\":\"O60906\"},{\"label\":\"Sphingomyelin phosphodiesterase 3\",\"id\":\"Q9NY59\"},{\"label\":\"Sphingomyelin phosphodiesterase 4\",\"id\":\"Q9NXE4\"},{\"label\":\"Sphingomyelin phosphodiesterase\",\"id\":\"P17405\"},{\"label\":\"Steryl-sulfatase\",\"id\":\"P08842\"}]", "uniprot_id": "[\"O60906\",\"P04062\",\"P06280\",\"P06865\",\"P07602\",\"P07686\",\"P08842\",\"P10619\",\"P15289\",\"P15848\",\"P16278\",\"P17405\",\"P17900\",\"P20645\",\"P51689\",\"P51690\",\"P54793\",\"P54803\",\"Q13510\",\"Q5FYA8\",\"Q5FYB0\",\"Q5FYB1\",\"Q6UWU2\",\"Q6UWV6\",\"Q6UWY0\",\"Q8IW92\",\"Q8NBJ7\",\"Q8NBK3\",\"Q8NCI6\",\"Q96EG1\",\"Q99519\",\"Q9H227\",\"Q9HCG7\",\"Q9NR71\",\"Q9NXE4\",\"Q9NY59\",\"Q9UQ49\",\"Q9Y3R4\"]", "gene_symbol": 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3\",\"id\":\"P27361\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"}]", "uniprot_id": "[\"O60674\",\"P01579\",\"P04049\",\"P15260\",\"P23458\",\"P27361\",\"P28482\",\"P38484\"]", "gene_symbol": "[\"ERK1\",\"ERK2\",\"IFNG\",\"IFNGR1\",\"IFNGR2\",\"IFNGT1\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"JAK2\",\"MAPK1\",\"MAPK3\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"RAF\",\"RAF1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ALG14 causes ALG14-CMS", "protein_name": "[{\"label\":\"UDP-N-acetylglucosamine transferase subunit ALG13\",\"id\":\"Q9NP73\"},{\"label\":\"UDP-N-acetylglucosamine transferase subunit ALG14\",\"id\":\"Q96F25\"}]", "uniprot_id": "[\"Q96F25\",\"Q9NP73\"]", "gene_symbol": "[\"ALG13\",\"ALG14\",\"CXorf45\",\"GLT28D1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Bicarbonate transporters", "protein_name": 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2\",\"id\":\"O14508\"},{\"label\":\"Suppressor of cytokine signaling 6\",\"id\":\"O14544\"},{\"label\":\"Tyrosine-protein kinase ABL2\",\"id\":\"P42684\"},{\"label\":\"Tyrosine-protein kinase CSK\",\"id\":\"P41240\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O14508\",\"O14544\",\"P0CG47\",\"P0CG48\",\"P22681\",\"P36888\",\"P41240\",\"P42684\",\"P49771\",\"P62979\",\"P62987\",\"Q12913\",\"Q13239\",\"Q9H6Q3\",\"Q9UQQ2\"]", "gene_symbol": "[\"ABL2\",\"ABLL\",\"ARG\",\"C20orf156\",\"CBL\",\"CBL2\",\"CD135\",\"CIS2\",\"CIS4\",\"CSK\",\"DEP1\",\"FLK2\",\"FLT3\",\"FLT3LG\",\"LNK\",\"PTPRJ\",\"RNF55\",\"RPS27A\",\"SH2B3\",\"SLA\",\"SLA2\",\"SLAP\",\"SLAP1\",\"SLAP2\",\"SOCS2\",\"SOCS4\",\"SOCS6\",\"SSI2\",\"STATI2\",\"STK1\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective B3GAT3 causes JDSSDHD", "protein_name": "[{\"label\":\"Agrin\",\"id\":\"O00468\"},{\"label\":\"Basement membrane-specific heparan sulfate proteoglycan core protein\",\"id\":\"P98160\"},{\"label\":\"Biglycan\",\"id\":\"P21810\"},{\"label\":\"Brevican core protein\",\"id\":\"Q96GW7\"},{\"label\":\"Chondroitin sulfate proteoglycan 4\",\"id\":\"Q6UVK1\"},{\"label\":\"Chondroitin sulfate proteoglycan 5\",\"id\":\"O95196\"},{\"label\":\"Decorin\",\"id\":\"P07585\"},{\"label\":\"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3\",\"id\":\"O94766\"},{\"label\":\"Glypican-1\",\"id\":\"P35052\"},{\"label\":\"Glypican-2\",\"id\":\"Q8N158\"},{\"label\":\"Glypican-3\",\"id\":\"P51654\"},{\"label\":\"Glypican-4\",\"id\":\"O75487\"},{\"label\":\"Glypican-5\",\"id\":\"P78333\"},{\"label\":\"Glypican-6\",\"id\":\"Q9Y625\"},{\"label\":\"Neurocan core protein\",\"id\":\"O14594\"},{\"label\":\"Syndecan-1\",\"id\":\"P18827\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Syndecan-3\",\"id\":\"O75056\"},{\"label\":\"Syndecan-4\",\"id\":\"P31431\"},{\"label\":\"Versican core protein\",\"id\":\"P13611\"}]", "uniprot_id": "[\"O00468\",\"O14594\",\"O75056\",\"O75487\",\"O94766\",\"O95196\",\"P07585\",\"P13611\",\"P18827\",\"P21810\",\"P31431\",\"P34741\",\"P35052\",\"P51654\",\"P78333\",\"P98160\",\"Q6UVK1\",\"Q8N158\",\"Q96GW7\",\"Q9Y625\"]", "gene_symbol": "[\"AGRIN\",\"AGRN\",\"B3GAT3\",\"BCAN\",\"BEHAB\",\"BGN\",\"CALEB\",\"CSPG2\",\"CSPG3\",\"CSPG4\",\"CSPG5\",\"CSPG7\",\"DCN\",\"GPC1\",\"GPC2\",\"GPC3\",\"GPC4\",\"GPC5\",\"GPC6\",\"HSPG1\",\"HSPG2\",\"KIAA0468\",\"MCSP\",\"NCAN\",\"NEUR\",\"NGC\",\"OCI5\",\"SDC\",\"SDC1\",\"SDC2\",\"SDC3\",\"SDC4\",\"SLRR1A\",\"SLRR1B\",\"VCAN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ca activated K+ channels", "protein_name": "[{\"label\":\"Calcium-activated potassium channel subunit alpha-1\",\"id\":\"Q12791\"},{\"label\":\"Calcium-activated potassium channel subunit beta-1\",\"id\":\"Q16558\"},{\"label\":\"Calcium-activated potassium channel subunit beta-2\",\"id\":\"Q9Y691\"},{\"label\":\"Calcium-activated potassium channel subunit beta-3\",\"id\":\"Q9NPA1\"},{\"label\":\"Calcium-activated potassium channel subunit beta-4\",\"id\":\"Q86W47\"},{\"label\":\"Intermediate conductance calcium-activated potassium channel protein 4\",\"id\":\"O15554\"},{\"label\":\"Small conductance calcium-activated potassium channel protein 1\",\"id\":\"Q92952\"},{\"label\":\"Small conductance calcium-activated potassium channel protein 2\",\"id\":\"Q9H2S1\"},{\"label\":\"Small conductance calcium-activated potassium channel protein 3\",\"id\":\"Q9UGI6\"}]", "uniprot_id": "[\"O15554\",\"Q12791\",\"Q16558\",\"Q86W47\",\"Q92952\",\"Q9H2S1\",\"Q9NPA1\",\"Q9UGI6\",\"Q9Y691\"]", "gene_symbol": 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6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Derlin-2\",\"id\":\"Q9GZP9\"},{\"label\":\"Desert hedgehog protein\",\"id\":\"O43323\"},{\"label\":\"E3 ubiquitin-protein ligase synoviolin\",\"id\":\"Q86TM6\"},{\"label\":\"Endoplasmic reticulum lectin 1\",\"id\":\"Q96DZ1\"},{\"label\":\"Indian hedgehog protein\",\"id\":\"Q14623\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta 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"[\"\"]" }, { "pathway_label": "TNFR1-mediated ceramide production", "protein_name": "[{\"label\":\"Protein FAN\",\"id\":\"Q92636\"},{\"label\":\"Small ribosomal subunit protein RACK1\",\"id\":\"P63244\"},{\"label\":\"Sphingomyelin phosphodiesterase 2\",\"id\":\"O60906\"},{\"label\":\"Sphingomyelin phosphodiesterase 3\",\"id\":\"Q9NY59\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 1A\",\"id\":\"P19438\"},{\"label\":\"Tumor necrosis factor\",\"id\":\"P01375\"}]", "uniprot_id": "[\"O60906\",\"P01375\",\"P19438\",\"P63244\",\"Q92636\",\"Q9NY59\"]", "gene_symbol": "[\"FAN\",\"GNB2L1\",\"NSMAF\",\"RACK1\",\"SMPD2\",\"SMPD3\",\"TNF\",\"TNFA\",\"TNFAR\",\"TNFR1\",\"TNFRSF1A\",\"TNFSF2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Maturation of protein 3a", "protein_name": "[{\"label\":\"Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase\",\"id\":\"Q9H4F1\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2\",\"id\":\"Q9UJ37\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3\",\"id\":\"Q8NDV1\"},{\"label\":\"Beta-galactoside alpha-2,6-sialyltransferase 1\",\"id\":\"P15907\"},{\"label\":\"CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase\",\"id\":\"Q11203\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1\",\"id\":\"Q11201\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2\",\"id\":\"Q16842\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4\",\"id\":\"Q11206\"},{\"label\":\"ORF3a protein\",\"id\":\"P0DTC3\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 1\",\"id\":\"Q10472\"}]", "uniprot_id": "[\"P0DTC3\",\"P15907\",\"Q10472\",\"Q11201\",\"Q11203\",\"Q11206\",\"Q16842\",\"Q8NDV1\",\"Q9H4F1\",\"Q9UJ37\"]", "gene_symbol": 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"[{\"label\":\"Alpha-actinin-1\",\"id\":\"P12814\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Integrin alpha-2\",\"id\":\"P17301\"},{\"label\":\"Integrin alpha-6\",\"id\":\"P23229\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Integrin beta-4\",\"id\":\"P16144\"},{\"label\":\"Integrin beta-5\",\"id\":\"P18084\"},{\"label\":\"Peripheral plasma membrane protein CASK\",\"id\":\"O14936\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Syndecan-1\",\"id\":\"P18827\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Syndecan-3\",\"id\":\"O75056\"},{\"label\":\"Syndecan-4\",\"id\":\"P31431\"},{\"label\":\"Tenascin\",\"id\":\"P24821\"},{\"label\":\"Thrombospondin-1\",\"id\":\"P07996\"},{\"label\":\"Trafficking protein particle complex subunit 4\",\"id\":\"Q9Y296\"},{\"label\":\"Transforming growth factor beta-1 proprotein\",\"id\":\"P01137\"},{\"label\":\"Vitronectin\",\"id\":\"P04004\"}]", "uniprot_id": "[\"O14936\",\"O75056\",\"P01137\",\"P04004\",\"P05106\",\"P05556\",\"P06756\",\"P07996\",\"P09038\",\"P12814\",\"P16144\",\"P17252\",\"P17301\",\"P18084\",\"P18827\",\"P23229\",\"P24821\",\"P31431\",\"P34741\",\"Q9Y296\"]", "gene_symbol": "[\"ACTN1\",\"CASK\",\"CD49B\",\"FGF2\",\"FGFB\",\"FNRB\",\"GP3A\",\"HSPG1\",\"HXB\",\"ITGA2\",\"ITGA6\",\"ITGAV\",\"ITGB1\",\"ITGB3\",\"ITGB4\",\"ITGB5\",\"KIAA0468\",\"LIN2\",\"MDF2\",\"MSK12\",\"MSK8\",\"PKCA\",\"PRKACA\",\"PRKCA\",\"SBDN\",\"SDC\",\"SDC1\",\"SDC2\",\"SDC3\",\"SDC4\",\"TGFB\",\"TGFB1\",\"THBS1\",\"TNC\",\"TRAPPC4\",\"TSP\",\"TSP1\",\"VNRA\",\"VTN\",\"VTNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Small interfering RNA (siRNA) biogenesis", "protein_name": "[{\"label\":\"Endoribonuclease Dicer\",\"id\":\"Q9UPY3\"},{\"label\":\"Interferon-inducible double-stranded RNA-dependent protein kinase activator A\",\"id\":\"O75569\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"RISC-loading complex subunit TARBP2\",\"id\":\"Q15633\"},{\"label\":\"Translin-associated protein X\",\"id\":\"Q99598\"},{\"label\":\"Translin\",\"id\":\"Q15631\"}]", "uniprot_id": "[\"O75569\",\"Q15631\",\"Q15633\",\"Q99598\",\"Q9H9G7\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9UPY3\"]", "gene_symbol": "[\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"DICER\",\"DICER1\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"HERNA\",\"KIAA0928\",\"KIAA1567\",\"PACT\",\"PRKRA\",\"RAX\",\"TARBP2\",\"TRAX\",\"TRBP\",\"TSN\",\"TSNAX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Dopamine receptors", "protein_name": "[{\"label\":\"D(1A) dopamine receptor\",\"id\":\"P21728\"},{\"label\":\"D(1B) dopamine receptor\",\"id\":\"P21918\"},{\"label\":\"D(2) dopamine receptor\",\"id\":\"P14416\"},{\"label\":\"D(3) dopamine receptor\",\"id\":\"P35462\"},{\"label\":\"D(4) dopamine receptor\",\"id\":\"P21917\"}]", "uniprot_id": "[\"P14416\",\"P21728\",\"P21917\",\"P21918\",\"P35462\"]", "gene_symbol": "[\"DRD1\",\"DRD1B\",\"DRD1L2\",\"DRD2\",\"DRD3\",\"DRD4\",\"DRD5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ROBO receptors bind AKAP5", "protein_name": "[{\"label\":\"A-kinase anchor protein 5\",\"id\":\"P24588\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Roundabout homolog 2\",\"id\":\"Q9HCK4\"},{\"label\":\"Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform\",\"id\":\"P16298\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"},{\"label\":\"cAMP-dependent protein kinase type II-alpha regulatory subunit\",\"id\":\"P13861\"}]", "uniprot_id": "[\"P13861\",\"P16298\",\"P17252\",\"P17612\",\"P22612\",\"P22694\",\"P24588\",\"Q9HCK4\"]", "gene_symbol": "[\"AKAP5\",\"AKAP79\",\"CALNA2\",\"CALNB\",\"CNA2\",\"KIAA1568\",\"PKACA\",\"PKCA\",\"PKR2\",\"PPP3CB\",\"PRKACA\",\"PRKACB\",\"PRKACG\",\"PRKAR2\",\"PRKAR2A\",\"PRKCA\",\"ROBO2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SUMO is transferred from E1 to E2 (UBE2I, UBC9)", "protein_name": "[{\"label\":\"RWD domain-containing protein 3\",\"id\":\"Q9Y3V2\"},{\"label\":\"SUMO-activating enzyme subunit 1\",\"id\":\"Q9UBE0\"},{\"label\":\"SUMO-activating enzyme subunit 2\",\"id\":\"Q9UBT2\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"},{\"label\":\"Small ubiquitin-related modifier 2\",\"id\":\"P61956\"},{\"label\":\"Small ubiquitin-related modifier 3\",\"id\":\"P55854\"}]", "uniprot_id": "[\"P55854\",\"P61956\",\"P63165\",\"P63279\",\"Q9UBE0\",\"Q9UBT2\",\"Q9Y3V2\"]", "gene_symbol": "[\"AOS1\",\"RSUME\",\"RWDD3\",\"SAE1\",\"SAE2\",\"SMT3A\",\"SMT3B\",\"SMT3C\",\"SMT3H1\",\"SMT3H2\",\"SMT3H3\",\"SUA1\",\"SUMO1\",\"SUMO2\",\"SUMO3\",\"UBA2\",\"UBC9\",\"UBCE9\",\"UBE2I\",\"UBL1\",\"UBLE1A\",\"UBLE1B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective translocation of RB1 mutants to the nucleus", "protein_name": "[{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"}]", "uniprot_id": "[\"P06400\"]", "gene_symbol": "[\"RB1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective Mismatch Repair Associated With MSH3", "protein_name": "[{\"label\":\"DNA mismatch repair protein Msh2\",\"id\":\"P43246\"},{\"label\":\"DNA mismatch repair protein Msh3\",\"id\":\"P20585\"}]", "uniprot_id": "[\"P20585\",\"P43246\"]", "gene_symbol": "[\"DUC1\",\"DUG\",\"MSH2\",\"MSH3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "LGI-ADAM interactions", "protein_name": "[{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 11\",\"id\":\"O75078\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 22\",\"id\":\"Q9P0K1\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 23\",\"id\":\"O75077\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Leucine-rich glioma-inactivated protein 1\",\"id\":\"O95970\"},{\"label\":\"Leucine-rich repeat LGI family member 2\",\"id\":\"Q8N0V4\"},{\"label\":\"Leucine-rich repeat LGI family member 3\",\"id\":\"Q8N145\"},{\"label\":\"Leucine-rich repeat LGI family member 4\",\"id\":\"Q8N135\"},{\"label\":\"Syntaxin-1A\",\"id\":\"Q16623\"},{\"label\":\"Syntaxin-1B\",\"id\":\"P61266\"},{\"label\":\"Voltage-dependent calcium channel gamma-2 subunit\",\"id\":\"Q9Y698\"},{\"label\":\"Voltage-dependent calcium channel gamma-3 subunit\",\"id\":\"O60359\"},{\"label\":\"Voltage-dependent calcium channel gamma-4 subunit\",\"id\":\"Q9UBN1\"},{\"label\":\"Voltage-dependent calcium channel gamma-8 subunit\",\"id\":\"Q8WXS5\"}]", "uniprot_id": "[\"O60359\",\"O75077\",\"O75078\",\"O95970\",\"P61266\",\"P78352\",\"Q16623\",\"Q8N0V4\",\"Q8N135\",\"Q8N145\",\"Q8WXS5\",\"Q9P0K1\",\"Q9UBN1\",\"Q9Y698\"]", "gene_symbol": "[\"ADAM11\",\"ADAM22\",\"ADAM23\",\"CACNG2\",\"CACNG3\",\"CACNG4\",\"CACNG6\",\"CACNG8\",\"DLG4\",\"EPT\",\"KIAA1916\",\"LGI1\",\"LGI2\",\"LGI3\",\"LGI4\",\"LGIL2\",\"LGIL3\",\"LGIL4\",\"MDC\",\"MDC2\",\"MDC3\",\"PSD95\",\"STX1\",\"STX1A\",\"STX1B\",\"STX1B1\",\"STX1B2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Insulin processing", "protein_name": "[{\"label\":\"Carboxypeptidase E\",\"id\":\"P16870\"},{\"label\":\"Collectrin\",\"id\":\"Q9HBJ8\"},{\"label\":\"ERO1-like protein beta\",\"id\":\"Q86YB8\"},{\"label\":\"Exocyst complex component 1\",\"id\":\"Q9NV70\"},{\"label\":\"Exocyst complex component 2\",\"id\":\"Q96KP1\"},{\"label\":\"Exocyst complex component 3\",\"id\":\"O60645\"},{\"label\":\"Exocyst complex component 4\",\"id\":\"Q96A65\"},{\"label\":\"Exocyst complex component 5\",\"id\":\"O00471\"},{\"label\":\"Exocyst complex component 6\",\"id\":\"Q8TAG9\"},{\"label\":\"Exocyst complex component 7\",\"id\":\"Q9UPT5\"},{\"label\":\"Exocyst complex component 8\",\"id\":\"Q8IYI6\"},{\"label\":\"Insulin\",\"id\":\"P01308\"},{\"label\":\"Kinesin heavy chain isoform 5A\",\"id\":\"Q12840\"},{\"label\":\"Kinesin heavy chain isoform 5C\",\"id\":\"O60282\"},{\"label\":\"Kinesin-1 heavy chain\",\"id\":\"P33176\"},{\"label\":\"Neuroendocrine convertase 1\",\"id\":\"P29120\"},{\"label\":\"Neuroendocrine convertase 2\",\"id\":\"P16519\"},{\"label\":\"Protein disulfide-isomerase\",\"id\":\"P07237\"},{\"label\":\"Proton-coupled zinc antiporter SLC30A5\",\"id\":\"Q8TAD4\"},{\"label\":\"Proton-coupled zinc antiporter SLC30A8\",\"id\":\"Q8IWU4\"},{\"label\":\"Rab effector MyRIP\",\"id\":\"Q8NFW9\"},{\"label\":\"Ras-related protein Rab-27A\",\"id\":\"P51159\"},{\"label\":\"Syntaxin-1A\",\"id\":\"Q16623\"},{\"label\":\"Unconventional myosin-Va\",\"id\":\"Q9Y4I1\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"}]", "uniprot_id": "[\"O00471\",\"O60282\",\"O60645\",\"P01308\",\"P07237\",\"P16519\",\"P16870\",\"P29120\",\"P33176\",\"P51159\",\"P63027\",\"Q12840\",\"Q16623\",\"Q86YB8\",\"Q8IWU4\",\"Q8IYI6\",\"Q8NFW9\",\"Q8TAD4\",\"Q8TAG9\",\"Q96A65\",\"Q96KP1\",\"Q9HBJ8\",\"Q9NV70\",\"Q9UPT5\",\"Q9Y4I1\"]", "gene_symbol": "[\"CLTRN\",\"CPE\",\"ERBA2L\",\"ERO1B\",\"ERO1LB\",\"EXO70\",\"EXOC1\",\"EXOC2\",\"EXOC3\",\"EXOC4\",\"EXOC5\",\"EXOC6\",\"EXOC7\",\"EXOC8\",\"INS\",\"KIAA0531\",\"KIAA1067\",\"KIAA1699\",\"KIF5A\",\"KIF5B\",\"KIF5C\",\"KNS\",\"KNS1\",\"MYH12\",\"MYO5A\",\"MYRIP\",\"NEC1\",\"NEC2\",\"NKHC1\",\"NKHC2\",\"P4HB\",\"PCSK1\",\"PCSK2\",\"PDI\",\"PDIA1\",\"PO4DB\",\"RAB27\",\"RAB27A\",\"SEC10\",\"SEC10L1\",\"SEC15A\",\"SEC15L\",\"SEC15L1\",\"SEC3\",\"SEC3L1\",\"SEC5\",\"SEC5L1\",\"SEC6\",\"SEC6L1\",\"SEC8\",\"SEC8L1\",\"SLAC2C\",\"SLC30A5\",\"SLC30A8\",\"STX1\",\"STX1A\",\"SYB2\",\"TMEM27\",\"VAMP2\",\"ZNT5\",\"ZNT8\",\"ZNTL1\",\"ZTL1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Terminal pathway of complement", "protein_name": "[{\"label\":\"Clusterin\",\"id\":\"P10909\"},{\"label\":\"Complement C5\",\"id\":\"P01031\"},{\"label\":\"Complement component C6\",\"id\":\"P13671\"},{\"label\":\"Complement component C7\",\"id\":\"P10643\"},{\"label\":\"Complement component C8 alpha chain\",\"id\":\"P07357\"},{\"label\":\"Complement component C8 beta chain\",\"id\":\"P07358\"},{\"label\":\"Complement component C8 gamma chain\",\"id\":\"P07360\"},{\"label\":\"Complement component C9\",\"id\":\"P02748\"}]", "uniprot_id": "[\"P01031\",\"P02748\",\"P07357\",\"P07358\",\"P07360\",\"P10643\",\"P10909\",\"P13671\"]", "gene_symbol": "[\"APOJ\",\"C5\",\"C6\",\"C7\",\"C8A\",\"C8B\",\"C8G\",\"C9\",\"CLI\",\"CLU\",\"CPAMD4\",\"KUB1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "brigatinib-resistant ALK mutants", "protein_name": "[{\"label\":\"ALK tyrosine kinase receptor\",\"id\":\"Q9UM73\"}]", "uniprot_id": "[\"Q9UM73\"]", "gene_symbol": "[\"ALK\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)", "protein_name": "[{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 9\",\"id\":\"Q9NRM0\"}]", "uniprot_id": "[\"Q9NRM0\"]", "gene_symbol": "[\"GLUT9\",\"SLC2A9\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "Acyl chain remodelling of PG", "protein_name": "[{\"label\":\"Acyl-CoA\",\"id\":\"lysophosphatidylglycerol acyltransferase 1:Q92604\"},{\"label\":\"Cardiolipin synthase (CMP-forming)\",\"id\":\"Q9UJA2\"},{\"label\":\"Cytosolic phospholipase A2 beta\",\"id\":\"P0C869\"},{\"label\":\"Cytosolic phospholipase A2 delta\",\"id\":\"Q86XP0\"},{\"label\":\"Cytosolic phospholipase A2 zeta\",\"id\":\"Q68DD2\"},{\"label\":\"Cytosolic phospholipase A2\",\"id\":\"P47712\"},{\"label\":\"Group 10 secretory phospholipase A2\",\"id\":\"O15496\"},{\"label\":\"Group 3 secretory phospholipase A2\",\"id\":\"Q9NZ20\"},{\"label\":\"Group IID secretory phospholipase A2\",\"id\":\"Q9UNK4\"},{\"label\":\"Group IIE secretory phospholipase A2\",\"id\":\"Q9NZK7\"},{\"label\":\"Group IIF secretory phospholipase A2\",\"id\":\"Q9BZM2\"},{\"label\":\"Group XIIA secretory phospholipase A2\",\"id\":\"Q9BZM1\"},{\"label\":\"Lysophosphatidylcholine acyltransferase 1\",\"id\":\"Q8NF37\"},{\"label\":\"Lysophospholipid acyltransferase LPCAT4\",\"id\":\"Q643R3\"},{\"label\":\"Phospholipase A2 group V\",\"id\":\"P39877\"},{\"label\":\"Phospholipase A2, membrane associated\",\"id\":\"P14555\"},{\"label\":\"Phospholipase A2\",\"id\":\"P04054\"},{\"label\":\"Secretory phospholipase A2 receptor\",\"id\":\"Q13018\"}]", "uniprot_id": "[\"O15496\",\"P04054\",\"P0C869\",\"P14555\",\"P39877\",\"P47712\",\"Q13018\",\"Q643R3\",\"Q68DD2\",\"Q86XP0\",\"Q8NF37\",\"Q92604\",\"Q9BZM1\",\"Q9BZM2\",\"Q9NZ20\",\"Q9NZK7\",\"Q9UJA2\",\"Q9UNK4\"]", "gene_symbol": "[\"AGPAT7\",\"AYTL2\",\"AYTL3\",\"C20orf155\",\"CLEC13C\",\"CLS1\",\"CPLA2\",\"CRLS1\",\"FAM34A\",\"KIAA0205\",\"LPCAT1\",\"LPCAT4\",\"LPEAT2\",\"LPGAT1\",\"PFAAP3\",\"PLA2\",\"PLA2A\",\"PLA2B\",\"PLA2G10\",\"PLA2G12\",\"PLA2G12A\",\"PLA2G1B\",\"PLA2G2A\",\"PLA2G2D\",\"PLA2G2E\",\"PLA2G2F\",\"PLA2G3\",\"PLA2G4\",\"PLA2G4A\",\"PLA2G4B\",\"PLA2G4D\",\"PLA2G4F\",\"PLA2G5\",\"PLA2L\",\"PLA2R1\",\"PPLA2\",\"RASF-A\",\"SPLASH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of MITF-M-dependent genes involved in apoptosis", "protein_name": "[{\"label\":\"Adenosine 5'-monophosphoramidase HINT1\",\"id\":\"P49773\"},{\"label\":\"Apoptosis regulator Bcl-2\",\"id\":\"P10415\"},{\"label\":\"Baculoviral IAP repeat-containing protein 7\",\"id\":\"Q96CA5\"},{\"label\":\"Bcl-2-related protein A1\",\"id\":\"Q16548\"},{\"label\":\"Endoribonuclease Dicer\",\"id\":\"Q9UPY3\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"POU domain, class 3, transcription factor 2\",\"id\":\"P20265\"},{\"label\":\"Paired amphipathic helix protein Sin3a\",\"id\":\"Q96ST3\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 1\",\"id\":\"Q7Z4N2\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"}]", "uniprot_id": "[\"P10415\",\"P20265\",\"P49773\",\"Q13547\",\"Q16548\",\"Q7Z4N2\",\"Q8NDV7\",\"Q96CA5\",\"Q96ST3\",\"Q9H9G7\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9UPQ9\",\"Q9UPY3\"]", "gene_symbol": "[\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"BCL2\",\"BCL2A1\",\"BCL2L5\",\"BFL1\",\"BIRC7\",\"BRN2\",\"CAGH26\",\"DICER\",\"DICER1\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"GRS\",\"HBPA1\",\"HDAC1\",\"HERNA\",\"HINT\",\"HINT1\",\"KIAA0928\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"KIAA1631\",\"KIAP\",\"LIVIN\",\"LTRPC1\",\"MLIAP\",\"MLSN\",\"MLSN1\",\"MOV10\",\"OCT7\",\"OTF7\",\"PKCI1\",\"POU3F2\",\"PRKCNH1\",\"RNF50\",\"RPD3L1\",\"SIN3A\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\",\"TRPM1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective CSF2RA causes SMDP4", "protein_name": "[{\"label\":\"Cytokine receptor common subunit beta\",\"id\":\"P32927\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor receptor subunit alpha\",\"id\":\"P15509\"},{\"label\":\"Pulmonary surfactant-associated protein A1\",\"id\":\"Q8IWL2\"},{\"label\":\"Pulmonary surfactant-associated protein A2\",\"id\":\"Q8IWL1\"},{\"label\":\"Pulmonary surfactant-associated protein B\",\"id\":\"P07988\"},{\"label\":\"Pulmonary surfactant-associated protein D\",\"id\":\"P35247\"},{\"label\":\"Surfactant protein C\",\"id\":\"P11686\"},{\"label\":\"Surfactant-associated protein 3\",\"id\":\"P0C7M3\"}]", "uniprot_id": "[\"P07988\",\"P0C7M3\",\"P11686\",\"P15509\",\"P32927\",\"P35247\",\"Q8IWL1\",\"Q8IWL2\"]", "gene_symbol": "[\"COLEC4\",\"COLEC5\",\"COLEC7\",\"CSF2R\",\"CSF2RA\",\"CSF2RB\",\"CSF2RY\",\"IL3RB\",\"IL5RB\",\"PSAP\",\"PSPD\",\"SFTA3\",\"SFTP1\",\"SFTP2\",\"SFTP3\",\"SFTP4\",\"SFTPA\",\"SFTPA1\",\"SFTPA1B\",\"SFTPA2\",\"SFTPA2B\",\"SFTPB\",\"SFTPC\",\"SFTPD\",\"SFTPH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)", "protein_name": "[{\"label\":\"Basigin\",\"id\":\"P35613\"},{\"label\":\"Monocarboxylate transporter 1\",\"id\":\"P53985\"}]", "uniprot_id": "[\"P35613\",\"P53985\"]", "gene_symbol": "[\"BSG\",\"MCT1\",\"SLC16A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Triglyceride biosynthesis", "protein_name": "[{\"label\":\"2-acylglycerol O-acyltransferase 1\",\"id\":\"Q96PD6\"},{\"label\":\"2-acylglycerol O-acyltransferase 2\",\"id\":\"Q3SYC2\"},{\"label\":\"2-acylglycerol O-acyltransferase 3\",\"id\":\"Q86VF5\"},{\"label\":\"Alkylglycerol monooxygenase\",\"id\":\"Q6ZNB7\"},{\"label\":\"Diacylglycerol O-acyltransferase 1\",\"id\":\"O75907\"},{\"label\":\"Diacylglycerol O-acyltransferase 2\",\"id\":\"Q96PD7\"},{\"label\":\"Glycerol kinase 2\",\"id\":\"Q14410\"},{\"label\":\"Glycerol kinase 3\",\"id\":\"Q14409\"},{\"label\":\"Glycerol kinase\",\"id\":\"P32189\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 1, mitochondrial\",\"id\":\"Q9HCL2\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 2, mitochondrial\",\"id\":\"Q6NUI2\"},{\"label\":\"Phosphatidate phosphatase LPIN1\",\"id\":\"Q14693\"},{\"label\":\"Phosphatidate phosphatase LPIN2\",\"id\":\"Q92539\"},{\"label\":\"Phosphatidate phosphatase LPIN3\",\"id\":\"Q9BQK8\"}]", "uniprot_id": "[\"O75907\",\"P32189\",\"Q14409\",\"Q14410\",\"Q14693\",\"Q3SYC2\",\"Q6NUI2\",\"Q6ZNB7\",\"Q86VF5\",\"Q92539\",\"Q96PD6\",\"Q96PD7\",\"Q9BQK8\",\"Q9HCL2\"]", "gene_symbol": "[\"AGMO\",\"AGRP1\",\"DC2\",\"DC5\",\"DC7\",\"DGAT\",\"DGAT1\",\"DGAT2\",\"DGAT2L1\",\"DGAT2L5\",\"DGAT2L7\",\"GK\",\"GK2\",\"GK3\",\"GK3P\",\"GKP2\",\"GKP3\",\"GKTA\",\"GKTB\",\"GPAM\",\"GPAT1\",\"GPAT2\",\"KIAA0188\",\"KIAA0249\",\"KIAA1560\",\"LIPN3L\",\"LPIN1\",\"LPIN2\",\"LPIN3\",\"MOGAT1\",\"MOGAT2\",\"MOGAT3\",\"TMEM195\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)", "protein_name": "[{\"label\":\"DNA ligase 1\",\"id\":\"P18858\"},{\"label\":\"DNA mismatch repair protein Mlh1\",\"id\":\"P40692\"},{\"label\":\"DNA mismatch repair protein Msh2\",\"id\":\"P43246\"},{\"label\":\"DNA mismatch repair protein Msh6\",\"id\":\"P52701\"},{\"label\":\"DNA polymerase delta catalytic subunit\",\"id\":\"P28340\"},{\"label\":\"DNA polymerase delta subunit 2\",\"id\":\"P49005\"},{\"label\":\"DNA polymerase delta subunit 3\",\"id\":\"Q15054\"},{\"label\":\"DNA polymerase delta subunit 4\",\"id\":\"Q9HCU8\"},{\"label\":\"Exonuclease 1\",\"id\":\"Q9UQ84\"},{\"label\":\"Mismatch repair endonuclease PMS2\",\"id\":\"P54278\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"}]", "uniprot_id": "[\"P12004\",\"P15927\",\"P18858\",\"P27694\",\"P28340\",\"P35244\",\"P40692\",\"P43246\",\"P49005\",\"P52701\",\"P54278\",\"Q15054\",\"Q9HCU8\",\"Q9UQ84\"]", "gene_symbol": "[\"COCA2\",\"EXO1\",\"EXOI\",\"GTBP\",\"HEX1\",\"KIAA0039\",\"LIG1\",\"MLH1\",\"MSH2\",\"MSH6\",\"PCNA\",\"PMS2\",\"PMSL2\",\"POLD\",\"POLD1\",\"POLD2\",\"POLD3\",\"POLD4\",\"POLDS\",\"REPA1\",\"REPA2\",\"REPA3\",\"RPA1\",\"RPA14\",\"RPA2\",\"RPA3\",\"RPA32\",\"RPA34\",\"RPA70\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Phosphorylation of Emi1", "protein_name": "[{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"F-box only protein 5\",\"id\":\"Q9UKT4\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"}]", "uniprot_id": "[\"P06493\",\"P14635\",\"P53350\",\"Q12834\",\"Q9UKT4\",\"Q9UM11\"]", "gene_symbol": "[\"CCNB\",\"CCNB1\",\"CDC2\",\"CDC20\",\"CDC28A\",\"CDH1\",\"CDK1\",\"CDKN1\",\"EMI1\",\"FBX5\",\"FBXO5\",\"FYR\",\"FZR\",\"FZR1\",\"KIAA1242\",\"P34CDC2\",\"PLK\",\"PLK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of caspases through apoptosome-mediated cleavage", "protein_name": "[{\"label\":\"Apoptotic protease-activating factor 1\",\"id\":\"O14727\"},{\"label\":\"Caspase-3\",\"id\":\"P42574\"},{\"label\":\"Caspase-7\",\"id\":\"P55210\"},{\"label\":\"Caspase-9\",\"id\":\"P55211\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"E3 ubiquitin-protein ligase XIAP\",\"id\":\"P98170\"}]", "uniprot_id": "[\"O14727\",\"P42574\",\"P55210\",\"P55211\",\"P98170\",\"P99999\"]", "gene_symbol": "[\"APAF1\",\"API3\",\"BIRC4\",\"CASP3\",\"CASP7\",\"CASP9\",\"CPP32\",\"CYC\",\"CYCS\",\"IAP3\",\"KIAA0413\",\"MCH3\",\"MCH6\",\"XIAP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Polymerase III Transcription Termination", "protein_name": "[{\"label\":\"DNA-directed RNA polymerase III subunit RPC10\",\"id\":\"Q9Y2Y1\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC1\",\"id\":\"O14802\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC2\",\"id\":\"Q9NW08\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC3\",\"id\":\"Q9BUI4\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC4\",\"id\":\"P05423\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC5\",\"id\":\"Q9NVU0\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC6\",\"id\":\"Q9H1D9\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7-like\",\"id\":\"Q9BT43\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7\",\"id\":\"O15318\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC8\",\"id\":\"Q9Y535\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC9\",\"id\":\"O75575\"},{\"label\":\"DNA-directed RNA polymerases I and III subunit RPAC1\",\"id\":\"O15160\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Lupus La protein\",\"id\":\"P05455\"},{\"label\":\"Nuclear factor 1 A-type\",\"id\":\"Q12857\"},{\"label\":\"Nuclear factor 1 B-type\",\"id\":\"O00712\"},{\"label\":\"Nuclear factor 1 C-type\",\"id\":\"P08651\"},{\"label\":\"Nuclear factor 1 X-type\",\"id\":\"Q14938\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"}]", "uniprot_id": "[\"O00712\",\"O14802\",\"O15160\",\"O15318\",\"O75575\",\"P05423\",\"P05455\",\"P08651\",\"P0DPB5\",\"P19388\",\"P52434\",\"P53803\",\"P61218\",\"P62875\",\"Q12857\",\"Q14938\",\"Q9BT43\",\"Q9BUI4\",\"Q9H1D9\",\"Q9NVU0\",\"Q9NW08\",\"Q9Y2Y1\",\"Q9Y535\"]", "gene_symbol": "[\"BN51\",\"BN51T\",\"CRCP\",\"KIAA1439\",\"KIAA1452\",\"KIAA1665\",\"NFI\",\"NFIA\",\"NFIB\",\"NFIC\",\"NFIX\",\"POLR1C\",\"POLR1D\",\"POLR1E\",\"POLR2E\",\"POLR2F\",\"POLR2H\",\"POLR2K\",\"POLR2L\",\"POLR3A\",\"POLR3B\",\"POLR3C\",\"POLR3D\",\"POLR3E\",\"POLR3F\",\"POLR3G\",\"POLR3GL\",\"POLR3H\",\"POLR3K\",\"POLRF\",\"RPC11\",\"RPC8\",\"SSB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Imatinib-resistant PDGFR mutants", "protein_name": "[{\"label\":\"Platelet-derived growth factor receptor alpha\",\"id\":\"P16234\"}]", "uniprot_id": "[\"P16234\"]", "gene_symbol": "[\"PDGFR2\",\"PDGFRA\",\"RHEPDGFRA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Eukaryotic Translation Elongation", "protein_name": "[{\"label\":\"Elongation factor 1-alpha 1\",\"id\":\"P68104\"},{\"label\":\"Elongation factor 1-alpha 2\",\"id\":\"Q05639\"},{\"label\":\"Elongation factor 1-beta\",\"id\":\"P24534\"},{\"label\":\"Elongation factor 1-delta\",\"id\":\"P29692\"},{\"label\":\"Elongation factor 1-gamma\",\"id\":\"P26641\"},{\"label\":\"Putative elongation factor 1-alpha-like 3\",\"id\":\"Q5VTE0\"}]", "uniprot_id": "[\"P24534\",\"P26641\",\"P29692\",\"P68104\",\"Q05639\",\"Q5VTE0\"]", "gene_symbol": "[\"EEF1A\",\"EEF1A1\",\"EEF1A1P5\",\"EEF1A2\",\"EEF1AL\",\"EEF1AL3\",\"EEF1B\",\"EEF1B2\",\"EEF1D\",\"EEF1G\",\"EF1A\",\"EF1B\",\"EF1D\",\"EF1G\",\"LENG7\",\"STN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Neurotransmitter release cycle", "protein_name": "[{\"label\":\"N-acylethanolamine-hydrolyzing acid amidase\",\"id\":\"Q02083\"}]", "uniprot_id": "[\"Q02083\"]", "gene_symbol": "[\"ASAHL\",\"NAAA\",\"PLT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Elevation of cytosolic Ca2+ levels", "protein_name": "[{\"label\":\"Calcium release-activated calcium channel protein 1\",\"id\":\"Q96D31\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1\",\"id\":\"Q14643\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2\",\"id\":\"Q14571\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3\",\"id\":\"Q14573\"},{\"label\":\"P2X purinoceptor 1\",\"id\":\"P51575\"},{\"label\":\"P2X purinoceptor 2\",\"id\":\"Q9UBL9\"},{\"label\":\"P2X purinoceptor 3\",\"id\":\"P56373\"},{\"label\":\"P2X purinoceptor 4\",\"id\":\"Q99571\"},{\"label\":\"P2X purinoceptor 5\",\"id\":\"Q93086\"},{\"label\":\"P2X purinoceptor 6\",\"id\":\"O15547\"},{\"label\":\"P2X purinoceptor 7\",\"id\":\"Q99572\"},{\"label\":\"Protein orai-2\",\"id\":\"Q96SN7\"},{\"label\":\"Short transient receptor potential channel 3\",\"id\":\"Q13507\"},{\"label\":\"Short transient receptor potential channel 6\",\"id\":\"Q9Y210\"},{\"label\":\"Short transient receptor potential channel 7\",\"id\":\"Q9HCX4\"},{\"label\":\"Stromal interaction molecule 1\",\"id\":\"Q13586\"}]", "uniprot_id": "[\"O15547\",\"P51575\",\"P56373\",\"Q13507\",\"Q13586\",\"Q14571\",\"Q14573\",\"Q14643\",\"Q93086\",\"Q96D31\",\"Q96SN7\",\"Q99571\",\"Q99572\",\"Q9HCX4\",\"Q9UBL9\",\"Q9Y210\"]", "gene_symbol": "[\"C7orf19\",\"CBCIP2\",\"CRACM1\",\"GOK\",\"INSP3R1\",\"ITPR1\",\"ITPR2\",\"ITPR3\",\"ORAI1\",\"ORAI2\",\"P2RX1\",\"P2RX2\",\"P2RX3\",\"P2RX4\",\"P2RX5\",\"P2RX6\",\"P2RX7\",\"P2RXL1\",\"P2X1\",\"P2X2\",\"P2X5\",\"P2X5FL\",\"P2X6\",\"STIM1\",\"TMEM142A\",\"TMEM142B\",\"TRP3\",\"TRP6\",\"TRP7\",\"TRPC3\",\"TRPC6\",\"TRPC7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Primitive streak formation", "protein_name": "[{\"label\":\"Bone morphogenetic protein 4\",\"id\":\"P12644\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM33\",\"id\":\"Q9UPN9\"},{\"label\":\"Eomesodermin homolog\",\"id\":\"O95936\"},{\"label\":\"Forkhead box protein H1\",\"id\":\"O75593\"},{\"label\":\"Homeobox protein MIXL1\",\"id\":\"Q9H2W2\"},{\"label\":\"Homeobox protein NANOG\",\"id\":\"Q9H9S0\"},{\"label\":\"Homeobox protein goosecoid\",\"id\":\"P56915\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Mothers against decapentaplegic homolog 2\",\"id\":\"Q15796\"},{\"label\":\"Mothers against decapentaplegic homolog 3\",\"id\":\"P84022\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"POU domain, class 5, transcription factor 1\",\"id\":\"Q01860\"},{\"label\":\"T-box transcription factor T\",\"id\":\"O15178\"},{\"label\":\"TATA box-binding protein-like 2\",\"id\":\"Q6SJ96\"},{\"label\":\"Transcription factor 7\",\"id\":\"P36402\"},{\"label\":\"Transcription factor SOX-2\",\"id\":\"P48431\"}]", "uniprot_id": "[\"O15178\",\"O75593\",\"O95936\",\"P12644\",\"P35222\",\"P36402\",\"P48431\",\"P56915\",\"P84022\",\"Q01860\",\"Q13485\",\"Q15796\",\"Q6SJ96\",\"Q9H2W2\",\"Q9H9S0\",\"Q9UJU2\",\"Q9UPN9\"]", "gene_symbol": "[\"BMP2B\",\"BMP4\",\"CTNNB\",\"CTNNB1\",\"DPC4\",\"DVR4\",\"EOMES\",\"FAST1\",\"FAST2\",\"FOXH1\",\"GSC\",\"KIAA1113\",\"LEF1\",\"MADH2\",\"MADH3\",\"MADH4\",\"MADR2\",\"MIXL\",\"MIXL1\",\"NANOG\",\"OCT3\",\"OCT4\",\"OTF3\",\"POU5F1\",\"RFG7\",\"SMAD2\",\"SMAD3\",\"SMAD4\",\"SOX2\",\"T\",\"TBP2\",\"TBPL2\",\"TBR2\",\"TBXT\",\"TCF1\",\"TCF7\",\"TIF1G\",\"TRF3\",\"TRIM33\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective DPM3 causes CDG-1o", "protein_name": "[{\"label\":\"Dolichol phosphate-mannose biosynthesis regulatory protein\",\"id\":\"O94777\"},{\"label\":\"Dolichol-phosphate mannosyltransferase subunit 1\",\"id\":\"O60762\"},{\"label\":\"Dolichol-phosphate mannosyltransferase subunit 3\",\"id\":\"Q9P2X0\"}]", "uniprot_id": "[\"O60762\",\"O94777\",\"Q9P2X0\"]", "gene_symbol": "[\"DPM1\",\"DPM2\",\"DPM3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NCAM signaling for neurite out-growth", "protein_name": "[{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Neural cell adhesion molecule 1\",\"id\":\"P13591\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase alpha\",\"id\":\"P18433\"},{\"label\":\"Ribosomal protein S6 kinase alpha-5\",\"id\":\"O75582\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Spectrin alpha chain, erythrocytic 1\",\"id\":\"P02549\"},{\"label\":\"Spectrin alpha chain, non-erythrocytic 1\",\"id\":\"Q13813\"},{\"label\":\"Spectrin beta chain, erythrocytic\",\"id\":\"P11277\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 1\",\"id\":\"Q01082\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 2\",\"id\":\"O15020\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 4\",\"id\":\"Q9H254\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 5\",\"id\":\"Q9NRC6\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"}]", "uniprot_id": "[\"O15020\",\"O75582\",\"P01111\",\"P01112\",\"P02549\",\"P06241\",\"P11277\",\"P13591\",\"P18433\",\"P27361\",\"P28482\",\"Q01082\",\"Q05397\",\"Q07889\",\"Q13813\",\"Q9H254\",\"Q9NRC6\"]", "gene_symbol": "[\"BSPECV\",\"ERK1\",\"ERK2\",\"FAK\",\"FAK1\",\"FYN\",\"HRAS\",\"HRAS1\",\"HUBSPECV\",\"HUSPECV\",\"KIAA0302\",\"KIAA1642\",\"MAPK1\",\"MAPK3\",\"MSK1\",\"NCAM\",\"NCAM1\",\"NEAS\",\"NRAS\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"PTK2\",\"PTPA\",\"PTPRA\",\"PTPRL2\",\"RPS6KA5\",\"SCA5\",\"SOS1\",\"SPTA\",\"SPTA1\",\"SPTA2\",\"SPTAN1\",\"SPTB\",\"SPTB1\",\"SPTB2\",\"SPTBN1\",\"SPTBN2\",\"SPTBN3\",\"SPTBN4\",\"SPTBN5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ligand-dependent caspase activation", "protein_name": "[{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"FAS-associated death domain protein\",\"id\":\"Q13158\"},{\"label\":\"FLICE inhibitory protein\",\"id\":\"Q76RF1\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"TIR domain-containing adapter molecule 2\",\"id\":\"Q86XR7\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 10\",\"id\":\"P50591\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 6\",\"id\":\"P48023\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10A\",\"id\":\"O00220\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10B\",\"id\":\"O14763\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 6\",\"id\":\"P25445\"},{\"label\":\"Tumor necrosis factor receptor type 1-associated DEATH domain protein\",\"id\":\"Q15628\"},{\"label\":\"Viral CASP8 and FADD-like apoptosis regulator\",\"id\":\"Q98325\"}]", "uniprot_id": "[\"O00206\",\"O00220\",\"O14763\",\"P08571\",\"P25445\",\"P48023\",\"P50591\",\"Q12933\",\"Q13158\",\"Q13546\",\"Q14790\",\"Q15628\",\"Q76RF1\",\"Q86XR7\",\"Q8IUC6\",\"Q98325\",\"Q9Y6Y9\"]", "gene_symbol": "[\"APO2\",\"APO2L\",\"APT1\",\"APT1LG1\",\"CASP8\",\"CD14\",\"CD95L\",\"DR4\",\"DR5\",\"ESOP1\",\"FADD\",\"FAS\",\"FAS1\",\"FASL\",\"FASLG\",\"KILLER\",\"LY96\",\"MC159L\",\"MCH5\",\"MD2\",\"MORT1\",\"ORF71\",\"PRVTIRB\",\"RIP\",\"RIP1\",\"RIPK1\",\"TICAM1\",\"TICAM2\",\"TIRAP3\",\"TIRP\",\"TLR4\",\"TNFRSF10A\",\"TNFRSF10B\",\"TNFRSF6\",\"TNFSF10\",\"TNFSF6\",\"TRADD\",\"TRAF2\",\"TRAIL\",\"TRAILR1\",\"TRAILR2\",\"TRAM\",\"TRAP3\",\"TRICK2\",\"TRIF\",\"ZTNFR9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Chondroitin sulfate biosynthesis", "protein_name": "[{\"label\":\"Biglycan\",\"id\":\"P21810\"},{\"label\":\"Brevican core protein\",\"id\":\"Q96GW7\"},{\"label\":\"Carbohydrate sulfotransferase 11\",\"id\":\"Q9NPF2\"},{\"label\":\"Carbohydrate sulfotransferase 12\",\"id\":\"Q9NRB3\"},{\"label\":\"Carbohydrate sulfotransferase 13\",\"id\":\"Q8NET6\"},{\"label\":\"Carbohydrate sulfotransferase 15\",\"id\":\"Q7LFX5\"},{\"label\":\"Carbohydrate sulfotransferase 3\",\"id\":\"Q7LGC8\"},{\"label\":\"Carbohydrate sulfotransferase 7\",\"id\":\"Q9NS84\"},{\"label\":\"Chondroitin sulfate N-acetylgalactosaminyltransferase 1\",\"id\":\"Q8TDX6\"},{\"label\":\"Chondroitin sulfate N-acetylgalactosaminyltransferase 2\",\"id\":\"Q8N6G5\"},{\"label\":\"Chondroitin sulfate glucuronyltransferase\",\"id\":\"Q9P2E5\"},{\"label\":\"Chondroitin sulfate proteoglycan 4\",\"id\":\"Q6UVK1\"},{\"label\":\"Chondroitin sulfate proteoglycan 5\",\"id\":\"O95196\"},{\"label\":\"Chondroitin sulfate synthase 1\",\"id\":\"Q86X52\"},{\"label\":\"Chondroitin sulfate synthase 2\",\"id\":\"Q8IZ52\"},{\"label\":\"Chondroitin sulfate synthase 3\",\"id\":\"Q70JA7\"},{\"label\":\"Decorin\",\"id\":\"P07585\"},{\"label\":\"Neurocan core protein\",\"id\":\"O14594\"},{\"label\":\"Versican core protein\",\"id\":\"P13611\"}]", "uniprot_id": "[\"O14594\",\"O95196\",\"P07585\",\"P13611\",\"P21810\",\"Q6UVK1\",\"Q70JA7\",\"Q7LFX5\",\"Q7LGC8\",\"Q86X52\",\"Q8IZ52\",\"Q8N6G5\",\"Q8NET6\",\"Q8TDX6\",\"Q96GW7\",\"Q9NPF2\",\"Q9NRB3\",\"Q9NS84\",\"Q9P2E5\"]", "gene_symbol": "[\"BCAN\",\"BEHAB\",\"BGN\",\"BRAG\",\"CALEB\",\"CHGN\",\"CHGN2\",\"CHPF\",\"CHPF2\",\"CHST11\",\"CHST12\",\"CHST13\",\"CHST15\",\"CHST3\",\"CHST7\",\"CHSY\",\"CHSY1\",\"CHSY2\",\"CHSY3\",\"CSGALNACT1\",\"CSGALNACT2\",\"CSGLCAT\",\"CSPG2\",\"CSPG3\",\"CSPG4\",\"CSPG5\",\"CSPG7\",\"CSS1\",\"CSS2\",\"CSS3\",\"DCN\",\"GALNAC4S6ST\",\"GALNACT1\",\"GALNACT2\",\"KIAA0598\",\"KIAA0990\",\"KIAA1402\",\"MCSP\",\"NCAN\",\"NEUR\",\"NGC\",\"SLRR1A\",\"SLRR1B\",\"VCAN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective MUT causes MMAM", "protein_name": "[{\"label\":\"Methylmalonic aciduria type A protein, mitochondrial\",\"id\":\"Q8IVH4\"},{\"label\":\"Methylmalonyl-CoA mutase, mitochondrial\",\"id\":\"P22033\"}]", "uniprot_id": "[\"P22033\",\"Q8IVH4\"]", "gene_symbol": "[\"MMAA\",\"MMUT\",\"MUT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PI3K/AKT activation", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"High affinity nerve growth factor receptor\",\"id\":\"P04629\"},{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"}]", "uniprot_id": "[\"O00459\",\"P01138\",\"P04629\",\"P27986\",\"P35568\",\"P42336\",\"P42338\",\"P61586\",\"Q9Y4H2\"]", "gene_symbol": "[\"ARH12\",\"ARHA\",\"GRB1\",\"IRS1\",\"IRS2\",\"MTC\",\"NGF\",\"NGFB\",\"NTRK1\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3R1\",\"PIK3R2\",\"RHO12\",\"RHOA\",\"TRK\",\"TRKA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SMAC (DIABLO) binds to IAPs", "protein_name": "[{\"label\":\"Apoptotic protease-activating factor 1\",\"id\":\"O14727\"},{\"label\":\"Caspase-3\",\"id\":\"P42574\"},{\"label\":\"Caspase-7\",\"id\":\"P55210\"},{\"label\":\"Caspase-9\",\"id\":\"P55211\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"Diablo IAP-binding mitochondrial protein\",\"id\":\"Q9NR28\"},{\"label\":\"E3 ubiquitin-protein ligase XIAP\",\"id\":\"P98170\"}]", "uniprot_id": "[\"O14727\",\"P42574\",\"P55210\",\"P55211\",\"P98170\",\"P99999\",\"Q9NR28\"]", "gene_symbol": "[\"APAF1\",\"API3\",\"BIRC4\",\"CASP3\",\"CASP7\",\"CASP9\",\"CPP32\",\"CYC\",\"CYCS\",\"DIABLO\",\"IAP3\",\"KIAA0413\",\"MCH3\",\"MCH6\",\"SMAC\",\"XIAP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Receptor Mediated Mitophagy", "protein_name": "[{\"label\":\"Autophagy protein 5\",\"id\":\"Q9H1Y0\"},{\"label\":\"Casein kinase II subunit alpha'\",\"id\":\"P19784\"},{\"label\":\"Casein kinase II subunit alpha\",\"id\":\"P68400\"},{\"label\":\"Casein kinase II subunit beta\",\"id\":\"P67870\"},{\"label\":\"FUN14 domain-containing protein 1\",\"id\":\"Q8IVP5\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 3A\",\"id\":\"Q9H492\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 3B\",\"id\":\"Q9GZQ8\"},{\"label\":\"Serine/threonine-protein kinase ULK1\",\"id\":\"O75385\"},{\"label\":\"Ubiquitin-like protein ATG12\",\"id\":\"O94817\"}]", "uniprot_id": "[\"O75385\",\"O94817\",\"P19784\",\"P67870\",\"P68400\",\"Q8IVP5\",\"Q9GZQ8\",\"Q9H1Y0\",\"Q9H492\"]", "gene_symbol": "[\"APG12\",\"APG12L\",\"APG5L\",\"ASP\",\"ATG12\",\"ATG5\",\"CK2A1\",\"CK2A2\",\"CK2N\",\"CSNK2A1\",\"CSNK2A2\",\"CSNK2B\",\"FUNDC1\",\"G5A\",\"KIAA0722\",\"MAP1ALC3\",\"MAP1LC3A\",\"MAP1LC3B\",\"ULK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cytosolic sensors of pathogen-associated DNA", "protein_name": "[{\"label\":\"DNA-dependent protein kinase catalytic subunit\",\"id\":\"P78527\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC10\",\"id\":\"Q9Y2Y1\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC1\",\"id\":\"O14802\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC2\",\"id\":\"Q9NW08\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC3\",\"id\":\"Q9BUI4\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC4\",\"id\":\"P05423\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC5\",\"id\":\"Q9NVU0\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC6\",\"id\":\"Q9H1D9\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7-like\",\"id\":\"Q9BT43\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7\",\"id\":\"O15318\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC8\",\"id\":\"Q9Y535\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC9\",\"id\":\"O75575\"},{\"label\":\"DNA-directed RNA polymerases I and III subunit RPAC1\",\"id\":\"O15160\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Interferon-inducible protein AIM2\",\"id\":\"O14862\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"},{\"label\":\"X-ray repair cross-complementing protein 5\",\"id\":\"P13010\"},{\"label\":\"X-ray repair cross-complementing protein 6\",\"id\":\"P12956\"}]", "uniprot_id": "[\"O14802\",\"O14862\",\"O15160\",\"O15318\",\"O75575\",\"P05423\",\"P0DPB5\",\"P12956\",\"P13010\",\"P19388\",\"P49959\",\"P52434\",\"P53803\",\"P61218\",\"P62875\",\"P78527\",\"Q9BT43\",\"Q9BUI4\",\"Q9H1D9\",\"Q9NVU0\",\"Q9NW08\",\"Q9Y2Y1\",\"Q9Y535\"]", "gene_symbol": "[\"AIM2\",\"BN51\",\"BN51T\",\"CRCP\",\"G22P1\",\"G22P2\",\"HNGS1\",\"HYRC\",\"HYRC1\",\"KIAA1452\",\"KIAA1665\",\"MRE11\",\"MRE11A\",\"POLR1C\",\"POLR1D\",\"POLR1E\",\"POLR2E\",\"POLR2F\",\"POLR2H\",\"POLR2K\",\"POLR2L\",\"POLR3A\",\"POLR3B\",\"POLR3C\",\"POLR3D\",\"POLR3E\",\"POLR3F\",\"POLR3G\",\"POLR3GL\",\"POLR3H\",\"POLR3K\",\"POLRF\",\"PRKDC\",\"RPC11\",\"RPC8\",\"XRCC5\",\"XRCC6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NFE2L2 regulating ER-stress associated genes", "protein_name": "[{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-4\",\"id\":\"P18848\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"},{\"label\":\"Transcription factor MafK\",\"id\":\"O60675\"}]", "uniprot_id": "[\"O60675\",\"P18848\",\"Q09472\",\"Q16236\",\"Q92793\"]", "gene_symbol": "[\"ATF4\",\"CBP\",\"CREB2\",\"CREBBP\",\"EP300\",\"MAFK\",\"NFE2L2\",\"NRF2\",\"P300\",\"TXREB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Displacement of DNA glycosylase by APEX1", "protein_name": "[{\"label\":\"DNA repair nuclease/redox regulator APEX1\",\"id\":\"P27695\"},{\"label\":\"DNA-3-methyladenine glycosylase\",\"id\":\"P29372\"},{\"label\":\"Endonuclease III-like protein 1\",\"id\":\"P78549\"},{\"label\":\"G/T mismatch-specific thymine DNA glycosylase\",\"id\":\"Q13569\"},{\"label\":\"Methyl-CpG-binding domain protein 4\",\"id\":\"O95243\"},{\"label\":\"N-glycosylase/DNA lyase\",\"id\":\"O15527\"},{\"label\":\"Single-strand selective monofunctional uracil DNA glycosylase\",\"id\":\"Q53HV7\"}]", "uniprot_id": "[\"O15527\",\"O95243\",\"P27695\",\"P29372\",\"P78549\",\"Q13569\",\"Q53HV7\"]", "gene_symbol": "[\"AAG\",\"ANPG\",\"APE\",\"APE1\",\"APEX\",\"APEX1\",\"APX\",\"HAP1\",\"MBD4\",\"MED1\",\"MID1\",\"MMH\",\"MPG\",\"MUTM\",\"NTH1\",\"NTHL1\",\"OCTS3\",\"OGG1\",\"OGH1\",\"REF1\",\"SMUG1\",\"TDG\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MAPK3 (ERK1) activation", "protein_name": "[{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 1\",\"id\":\"Q02750\"},{\"label\":\"Interleukin-6 receptor subunit alpha\",\"id\":\"P08887\"},{\"label\":\"Interleukin-6\",\"id\":\"P05231\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O60674\",\"P05231\",\"P06493\",\"P08887\",\"P23458\",\"P27361\",\"P29597\",\"Q02750\",\"Q06124\"]", "gene_symbol": "[\"CDC2\",\"CDC28A\",\"CDK1\",\"CDKN1\",\"ERK1\",\"IFNB2\",\"IL6\",\"IL6R\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"JAK2\",\"MAP2K1\",\"MAPK3\",\"MEK1\",\"P34CDC2\",\"PRKM3\",\"PRKMK1\",\"PTP2C\",\"PTPN11\",\"SHPTP2\",\"TYK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Autointegration results in viral DNA circles", "protein_name": "[{\"label\":\"Barrier-to-autointegration factor\",\"id\":\"O75531\"},{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"High mobility group protein HMG-I/HMG-Y\",\"id\":\"P17096\"},{\"label\":\"PC4 and SFRS1-interacting protein\",\"id\":\"O75475\"},{\"label\":\"Protein Rev\",\"id\":\"P04618\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"O75475\",\"O75531\",\"P04585\",\"P04591\",\"P04618\",\"P05919\",\"P17096\",\"P69723\",\"P69726\"]", "gene_symbol": "[\"BAF\",\"BANF1\",\"BCRG1\",\"DFS70\",\"HMGA1\",\"HMGIY\",\"LEDGF\",\"PSIP1\",\"PSIP2\",\"gag\",\"gag-pol\",\"rev\",\"vif\",\"vpr\",\"vpu\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)", "protein_name": "[{\"label\":\"Eukaryotic initiation factor 4A-III\",\"id\":\"P38919\"},{\"label\":\"Eukaryotic peptide chain release factor GTP-binding subunit ERF3A\",\"id\":\"P15170\"},{\"label\":\"Eukaryotic peptide chain release factor GTP-binding subunit ERF3B\",\"id\":\"Q8IYD1\"},{\"label\":\"Eukaryotic peptide chain release factor subunit 1\",\"id\":\"P62495\"},{\"label\":\"Eukaryotic translation initiation factor 4 gamma 1\",\"id\":\"Q04637\"},{\"label\":\"Large ribosomal subunit protein P1\",\"id\":\"P05386\"},{\"label\":\"Large ribosomal subunit protein P2\",\"id\":\"P05387\"},{\"label\":\"Large ribosomal subunit protein eL13\",\"id\":\"P26373\"},{\"label\":\"Large ribosomal subunit protein eL14\",\"id\":\"P50914\"},{\"label\":\"Large ribosomal subunit protein eL15\",\"id\":\"P61313\"},{\"label\":\"Large ribosomal subunit protein eL18\",\"id\":\"Q07020\"},{\"label\":\"Large ribosomal subunit protein eL19\",\"id\":\"P84098\"},{\"label\":\"Large ribosomal subunit protein eL20\",\"id\":\"Q02543\"},{\"label\":\"Large ribosomal subunit protein eL21\",\"id\":\"P46778\"},{\"label\":\"Large ribosomal subunit protein eL22\",\"id\":\"P35268\"},{\"label\":\"Large ribosomal subunit protein eL24\",\"id\":\"P83731\"},{\"label\":\"Large ribosomal subunit protein eL27\",\"id\":\"P61353\"},{\"label\":\"Large ribosomal subunit protein eL28\",\"id\":\"P46779\"},{\"label\":\"Large ribosomal subunit protein eL29\",\"id\":\"P47914\"},{\"label\":\"Large ribosomal subunit protein eL30\",\"id\":\"P62888\"},{\"label\":\"Large ribosomal subunit protein eL31\",\"id\":\"P62899\"},{\"label\":\"Large ribosomal subunit protein eL32\",\"id\":\"P62910\"},{\"label\":\"Large ribosomal subunit protein eL33\",\"id\":\"P18077\"},{\"label\":\"Large ribosomal subunit protein eL34\",\"id\":\"P49207\"},{\"label\":\"Large ribosomal subunit protein eL36\",\"id\":\"Q9Y3U8\"},{\"label\":\"Large ribosomal subunit protein eL37\",\"id\":\"P61927\"},{\"label\":\"Large ribosomal subunit protein eL38\",\"id\":\"P63173\"},{\"label\":\"Large ribosomal subunit protein eL39\",\"id\":\"P62891\"},{\"label\":\"Large ribosomal subunit protein eL42\",\"id\":\"P83881\"},{\"label\":\"Large ribosomal subunit protein eL43\",\"id\":\"P61513\"},{\"label\":\"Large ribosomal subunit protein eL6\",\"id\":\"Q02878\"},{\"label\":\"Large ribosomal subunit protein eL8\",\"id\":\"P62424\"},{\"label\":\"Large ribosomal subunit protein uL10\",\"id\":\"P05388\"},{\"label\":\"Large ribosomal subunit protein uL11\",\"id\":\"P30050\"},{\"label\":\"Large ribosomal subunit protein uL13\",\"id\":\"P40429\"},{\"label\":\"Large ribosomal subunit protein uL14\",\"id\":\"P62829\"},{\"label\":\"Large ribosomal subunit protein uL15\",\"id\":\"P46776\"},{\"label\":\"Large ribosomal subunit protein uL16\",\"id\":\"P27635\"},{\"label\":\"Large ribosomal subunit protein uL18\",\"id\":\"P46777\"},{\"label\":\"Large ribosomal subunit protein uL1\",\"id\":\"P62906\"},{\"label\":\"Large ribosomal subunit protein uL22\",\"id\":\"P18621\"},{\"label\":\"Large ribosomal subunit protein uL23\",\"id\":\"P62750\"},{\"label\":\"Large ribosomal subunit protein uL24\",\"id\":\"P61254\"},{\"label\":\"Large ribosomal subunit protein uL29\",\"id\":\"P42766\"},{\"label\":\"Large ribosomal subunit protein uL2\",\"id\":\"P62917\"},{\"label\":\"Large ribosomal subunit protein uL30\",\"id\":\"P18124\"},{\"label\":\"Large ribosomal subunit protein uL3\",\"id\":\"P39023\"},{\"label\":\"Large ribosomal subunit protein uL4\",\"id\":\"P36578\"},{\"label\":\"Large ribosomal subunit protein uL5\",\"id\":\"P62913\"},{\"label\":\"Large ribosomal subunit protein uL6\",\"id\":\"P32969\"},{\"label\":\"Nonsense-mediated mRNA decay factor SMG5\",\"id\":\"Q9UPR3\"},{\"label\":\"Nonsense-mediated mRNA decay factor SMG7\",\"id\":\"Q92540\"},{\"label\":\"Nonsense-mediated mRNA decay factor SMG8\",\"id\":\"Q8ND04\"},{\"label\":\"Nonsense-mediated mRNA decay factor SMG9\",\"id\":\"Q9H0W8\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Polyadenylate-binding protein 1\",\"id\":\"P11940\"},{\"label\":\"Proline-rich nuclear receptor coactivator 2\",\"id\":\"Q9NPJ4\"},{\"label\":\"Protein CASC3\",\"id\":\"O15234\"},{\"label\":\"Protein mago nashi homolog 2\",\"id\":\"Q96A72\"},{\"label\":\"Protein mago nashi homolog\",\"id\":\"P61326\"},{\"label\":\"RNA-binding protein 8A\",\"id\":\"Q9Y5S9\"},{\"label\":\"RNA-binding protein with serine-rich domain 1\",\"id\":\"Q15287\"},{\"label\":\"Regulator of nonsense transcripts 1\",\"id\":\"Q92900\"},{\"label\":\"Regulator of nonsense transcripts 2\",\"id\":\"Q9HAU5\"},{\"label\":\"Regulator of nonsense transcripts 3A\",\"id\":\"Q9H1J1\"},{\"label\":\"Regulator of nonsense transcripts 3B\",\"id\":\"Q9BZI7\"},{\"label\":\"Ribosomal protein eL22-like\",\"id\":\"Q6P5R6\"},{\"label\":\"Ribosomal protein eL39-like 2\",\"id\":\"Q96EH5\"},{\"label\":\"Ribosomal protein eL42-like\",\"id\":\"Q969Q0\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Ribosomal protein uL16-like\",\"id\":\"Q96L21\"},{\"label\":\"Ribosomal protein uL24-like\",\"id\":\"Q9UNX3\"},{\"label\":\"Ribosomal protein uL3-like\",\"id\":\"Q92901\"},{\"label\":\"Serine/threonine-protein kinase SMG1\",\"id\":\"Q96Q15\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform\",\"id\":\"P63151\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory 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ribosomal subunit protein uS19\",\"id\":\"P62841\"},{\"label\":\"Small ribosomal subunit protein uS2\",\"id\":\"P08865\"},{\"label\":\"Small ribosomal subunit protein uS3\",\"id\":\"P23396\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small ribosomal subunit protein uS7\",\"id\":\"P46782\"},{\"label\":\"Small ribosomal subunit protein uS8\",\"id\":\"P62244\"},{\"label\":\"Small ribosomal subunit protein uS9\",\"id\":\"P62249\"},{\"label\":\"Telomerase-binding protein EST1A\",\"id\":\"Q86US8\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"mRNA-decapping enzyme 1A\",\"id\":\"Q9NPI6\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Cyclin D associated events in G1", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor B\",\"id\":\"P42772\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor C\",\"id\":\"P42773\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor D\",\"id\":\"P55273\"},{\"label\":\"Cyclin-dependent kinase 4\",\"id\":\"P11802\"},{\"label\":\"Cyclin-dependent kinase 6\",\"id\":\"Q00534\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1C\",\"id\":\"P49918\"},{\"label\":\"Cyclin-dependent kinase inhibitor 2A\",\"id\":\"P42771\"},{\"label\":\"Cyclin-dependent kinases regulatory subunit 1\",\"id\":\"P61024\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"G1/S-specific cyclin-D2\",\"id\":\"P30279\"},{\"label\":\"G1/S-specific cyclin-D3\",\"id\":\"P30281\"},{\"label\":\"G1/S-specific cyclin-E1\",\"id\":\"P24864\"},{\"label\":\"G1/S-specific cyclin-E2\",\"id\":\"O96020\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein-tyrosine kinase 6\",\"id\":\"Q13882\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Retinoblastoma-like protein 1\",\"id\":\"P28749\"},{\"label\":\"Retinoblastoma-like protein 2\",\"id\":\"Q08999\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"S-phase kinase-associated protein 2\",\"id\":\"Q13309\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform\",\"id\":\"P63151\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta\",\"id\":\"Q9Y5P8\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Transcription factor E2F2\",\"id\":\"Q14209\"},{\"label\":\"Transcription factor E2F3\",\"id\":\"O00716\"},{\"label\":\"Transcription factor E2F4\",\"id\":\"Q16254\"},{\"label\":\"Transcription factor 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5'-phosphosulfate transporter 1\",\"id\":\"Q8TB61\"},{\"label\":\"Adenosine 3'-phospho 5'-phosphosulfate transporter 2\",\"id\":\"Q9H1N7\"},{\"label\":\"CMP-sialic acid transporter\",\"id\":\"P78382\"},{\"label\":\"GDP-fucose transporter 1\",\"id\":\"Q96A29\"},{\"label\":\"Nucleotide sugar transporter SLC35B4\",\"id\":\"Q969S0\"},{\"label\":\"Nucleotide sugar transporter SLC35D1\",\"id\":\"Q9NTN3\"},{\"label\":\"Nucleotide sugar transporter SLC35D2\",\"id\":\"Q76EJ3\"},{\"label\":\"UDP-N-acetylglucosamine transporter\",\"id\":\"Q9Y2D2\"},{\"label\":\"UDP-galactose translocator\",\"id\":\"P78381\"}]", "uniprot_id": "[\"P78381\",\"P78382\",\"Q76EJ3\",\"Q8TB61\",\"Q969S0\",\"Q96A29\",\"Q9H1N7\",\"Q9NTN3\",\"Q9Y2D2\"]", "gene_symbol": "[\"C6orf196\",\"FUCT1\",\"HFRC\",\"KIAA0260\",\"PAPST1\",\"PAPST2\",\"SLC35A1\",\"SLC35A2\",\"SLC35A3\",\"SLC35B2\",\"SLC35B3\",\"SLC35B4\",\"SLC35C1\",\"SLC35D1\",\"SLC35D2\",\"UGALT\",\"UGT\",\"UGTL\",\"UGTREL7\",\"UGTREL8\",\"YEA4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activated NTRK3 signals through PLCG1", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"NT-3 growth factor receptor\",\"id\":\"Q16288\"},{\"label\":\"Neurotrophin-3\",\"id\":\"P20783\"}]", "uniprot_id": "[\"P19174\",\"P20783\",\"Q16288\"]", "gene_symbol": "[\"NTF3\",\"NTRK3\",\"PLC1\",\"PLCG1\",\"TRKC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Digestion of dietary lipid", "protein_name": "[{\"label\":\"Bile salt-activated lipase\",\"id\":\"P19835\"},{\"label\":\"Colipase\",\"id\":\"P04118\"},{\"label\":\"Gastric triacylglycerol lipase\",\"id\":\"P07098\"},{\"label\":\"Inactive pancreatic lipase-related protein 1\",\"id\":\"P54315\"},{\"label\":\"Pancreatic lipase-related protein 2\",\"id\":\"P54317\"},{\"label\":\"Pancreatic lipase-related protein 3\",\"id\":\"Q17RR3\"},{\"label\":\"Pancreatic triacylglycerol lipase\",\"id\":\"P16233\"}]", "uniprot_id": 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guanine nucleotide exchange factor 7\",\"id\":\"Q14155\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"Syntenin-1\",\"id\":\"O00560\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"}]", "uniprot_id": "[\"O00560\",\"O15197\",\"O43639\",\"O75914\",\"P06241\",\"P19105\",\"P29323\",\"P52799\",\"P54753\",\"P54760\",\"P54762\",\"P63000\",\"P98172\",\"Q13153\",\"Q13177\",\"Q14155\",\"Q15768\",\"Q9Y2X7\"]", "gene_symbol": 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protein\",\"id\":\"Q7Z434\"},{\"label\":\"Serine/threonine-protein kinase TBK1\",\"id\":\"Q9UHD2\"},{\"label\":\"Suppressor of IKBKE 1\",\"id\":\"Q9BRV8\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"TRAF family member-associated NF-kappa-B activator\",\"id\":\"Q92844\"}]", "uniprot_id": "[\"O95786\",\"P01562\",\"P01563\",\"P01566\",\"P01567\",\"P01568\",\"P01569\",\"P01570\",\"P01571\",\"P01574\",\"P05013\",\"P05014\",\"P05015\",\"P32881\",\"Q09472\",\"Q12933\",\"Q14164\",\"Q14258\",\"Q14653\",\"Q7Z434\",\"Q8IUD6\",\"Q92793\",\"Q92844\",\"Q92985\",\"Q9BRV8\",\"Q9BYX4\",\"Q9C037\",\"Q9UHD2\",\"Q9Y4K3\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of IGF Activity by IGFBP", "protein_name": "[{\"label\":\"72 kDa type IV collagenase\",\"id\":\"P08253\"},{\"label\":\"Albumin\",\"id\":\"P02768\"},{\"label\":\"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A\",\"id\":\"Q9UM21\"},{\"label\":\"Alpha-1-antitrypsin\",\"id\":\"P01009\"},{\"label\":\"Alpha-2-HS-glycoprotein\",\"id\":\"P02765\"},{\"label\":\"Alpha-fetoprotein\",\"id\":\"P02771\"},{\"label\":\"Ameloblastin\",\"id\":\"Q9NP70\"},{\"label\":\"Amelogenin, X isoform\",\"id\":\"Q99217\"},{\"label\":\"Amelotin\",\"id\":\"Q6UX39\"},{\"label\":\"Amyloid beta precursor like protein 2\",\"id\":\"Q06481\"},{\"label\":\"Amyloid-beta precursor protein\",\"id\":\"P05067\"},{\"label\":\"Anoctamin-8\",\"id\":\"Q9HCE9\"},{\"label\":\"Antithrombin-III\",\"id\":\"P01008\"},{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Apolipoprotein A-II\",\"id\":\"P02652\"},{\"label\":\"Apolipoprotein A-V\",\"id\":\"Q6Q788\"},{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Apolipoprotein E\",\"id\":\"P02649\"},{\"label\":\"Apolipoprotein L1\",\"id\":\"O14791\"},{\"label\":\"BPI fold-containing family B member 2\",\"id\":\"Q8N4F0\"},{\"label\":\"Bone morphogenetic protein 15\",\"id\":\"O95972\"},{\"label\":\"Bone morphogenetic protein 4\",\"id\":\"P12644\"},{\"label\":\"CCN family member 1\",\"id\":\"O00622\"},{\"label\":\"Cadherin-2\",\"id\":\"P19022\"},{\"label\":\"Calumenin\",\"id\":\"O43852\"},{\"label\":\"Cathepsin G\",\"id\":\"P08311\"},{\"label\":\"Ceruloplasmin\",\"id\":\"P00450\"},{\"label\":\"Chordin-like protein 1\",\"id\":\"Q9BU40\"},{\"label\":\"Coagulation factor V\",\"id\":\"P12259\"},{\"label\":\"Complement C3\",\"id\":\"P01024\"},{\"label\":\"Complement C4-A\",\"id\":\"P0C0L4\"},{\"label\":\"Cystatin-C\",\"id\":\"P01034\"},{\"label\":\"Cytoskeleton-associated protein 4\",\"id\":\"Q07065\"},{\"label\":\"Dentin matrix acidic phosphoprotein 1\",\"id\":\"Q13316\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 10\",\"id\":\"O14672\"},{\"label\":\"DnaJ homolog subfamily C member 3\",\"id\":\"Q13217\"},{\"label\":\"Enamelin\",\"id\":\"Q9NRM1\"},{\"label\":\"Endoplasmin\",\"id\":\"P14625\"},{\"label\":\"Extracellular serine/threonine protein kinase FAM20C\",\"id\":\"Q8IXL6\"},{\"label\":\"Fibrillin-1\",\"id\":\"P35555\"},{\"label\":\"Fibrinogen alpha chain\",\"id\":\"P02671\"},{\"label\":\"Fibrinogen gamma chain\",\"id\":\"P02679\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibronectin\",\"id\":\"P02751\"},{\"label\":\"Follistatin-related protein 1\",\"id\":\"Q12841\"},{\"label\":\"Follistatin-related protein 3\",\"id\":\"O95633\"},{\"label\":\"Galectin-1\",\"id\":\"P09382\"},{\"label\":\"Glucosidase 2 subunit beta\",\"id\":\"P14314\"},{\"label\":\"Glypican-3\",\"id\":\"P51654\"},{\"label\":\"Golgi membrane protein 1\",\"id\":\"Q8NBJ4\"},{\"label\":\"Granzyme 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8\",\"id\":\"Q9BRK3\"},{\"label\":\"Melanotransferrin\",\"id\":\"P08582\"},{\"label\":\"Membrane-bound transcription factor site-1 protease\",\"id\":\"Q14703\"},{\"label\":\"Menin\",\"id\":\"O00255\"},{\"label\":\"Mesothelin\",\"id\":\"Q13421\"},{\"label\":\"Metalloproteinase inhibitor 1\",\"id\":\"P01033\"},{\"label\":\"Neurosecretory protein VGF\",\"id\":\"O15240\"},{\"label\":\"Nucleobindin-1\",\"id\":\"Q02818\"},{\"label\":\"Osteopontin\",\"id\":\"P10451\"},{\"label\":\"Palmitoleoyl-protein carboxylesterase NOTUM\",\"id\":\"Q6P988\"},{\"label\":\"Pappalysin-1\",\"id\":\"Q13219\"},{\"label\":\"Pappalysin-2\",\"id\":\"Q9BXP8\"},{\"label\":\"Patatin-like phospholipase domain-containing protein 2\",\"id\":\"Q96AD5\"},{\"label\":\"Plasma alpha-L-fucosidase\",\"id\":\"Q9BTY2\"},{\"label\":\"Plasminogen\",\"id\":\"P00747\"},{\"label\":\"Proenkephalin-A\",\"id\":\"P01210\"},{\"label\":\"Proprotein convertase subtilisin/kexin type 9\",\"id\":\"Q8NBP7\"},{\"label\":\"Prostate-specific 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18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 22\",\"id\":\"Q9HCT0\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 3\",\"id\":\"P11487\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 7\",\"id\":\"P21781\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O15520\",\"O43320\",\"O76093\",\"P01111\",\"P01112\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11487\",\"P21781\",\"P31371\",\"Q07889\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", 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"[\"\"]" }, { "pathway_label": "Paradoxical activation of RAF signaling by kinase inactive BRAF", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein\",\"id\":\"Q7Z5R6\"},{\"label\":\"BRCA1-associated protein\",\"id\":\"Q7Z569\"},{\"label\":\"Beta-arrestin-1\",\"id\":\"P49407\"},{\"label\":\"Beta-arrestin-2\",\"id\":\"P32121\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Connector enhancer of kinase suppressor of ras 1\",\"id\":\"Q969H4\"},{\"label\":\"Connector 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1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 11\",\"id\":\"Q16584\"},{\"label\":\"Phosphatidylethanolamine-binding protein 1\",\"id\":\"P30086\"},{\"label\":\"Prohibitin 1\",\"id\":\"P35232\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP1\",\"id\":\"P46940\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"},{\"label\":\"Serine/threonine-protein kinase A-Raf\",\"id\":\"P10398\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"},{\"label\":\"Talin-1\",\"id\":\"Q9Y490\"},{\"label\":\"Tyrosine-protein kinase CSK\",\"id\":\"P41240\"},{\"label\":\"Tyrosine-protein kinase 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"gtc_id": "[\"\"]" }, { "pathway_label": "Type II Na+/Pi cotransporters", "protein_name": "[{\"label\":\"Sodium-dependent phosphate transport protein 2A\",\"id\":\"Q06495\"},{\"label\":\"Sodium-dependent phosphate transport protein 2B\",\"id\":\"O95436\"},{\"label\":\"Sodium-dependent phosphate transport protein 2C\",\"id\":\"Q8N130\"}]", "uniprot_id": "[\"O95436\",\"Q06495\",\"Q8N130\"]", "gene_symbol": "[\"NPT2\",\"NPT2C\",\"NPTIIC\",\"SLC17A2\",\"SLC34A1\",\"SLC34A2\",\"SLC34A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G alpha (z) signalling events", "protein_name": "[{\"label\":\"Adenylate cyclase type 1\",\"id\":\"Q08828\"},{\"label\":\"Adenylate cyclase type 2\",\"id\":\"Q08462\"},{\"label\":\"Adenylate cyclase type 3\",\"id\":\"O60266\"},{\"label\":\"Adenylate cyclase type 4\",\"id\":\"Q8NFM4\"},{\"label\":\"Adenylate cyclase type 5\",\"id\":\"O95622\"},{\"label\":\"Adenylate cyclase type 6\",\"id\":\"O43306\"},{\"label\":\"Adenylate cyclase type 7\",\"id\":\"P51828\"},{\"label\":\"Adenylate cyclase type 8\",\"id\":\"P40145\"},{\"label\":\"Adenylate cyclase type 9\",\"id\":\"O60503\"},{\"label\":\"Alpha-2A adrenergic receptor\",\"id\":\"P08913\"},{\"label\":\"Alpha-2B adrenergic receptor\",\"id\":\"P18089\"},{\"label\":\"Alpha-2C adrenergic receptor\",\"id\":\"P18825\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-1\",\"id\":\"P63096\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit 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"protein_name": "[{\"label\":\"Ribose-5-phosphate isomerase\",\"id\":\"P49247\"}]", "uniprot_id": "[\"P49247\"]", "gene_symbol": "[\"RPI\",\"RPIA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of the nephric duct", "protein_name": "[{\"label\":\"Bone morphogenetic protein 4\",\"id\":\"P12644\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"DNA-binding protein inhibitor ID-4\",\"id\":\"P47928\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Histone-lysine N-methyltransferase MECOM\",\"id\":\"Q03112\"},{\"label\":\"Homeobox protein EMX2\",\"id\":\"Q04743\"},{\"label\":\"Homeobox protein Hox-A6\",\"id\":\"P31267\"},{\"label\":\"Homeobox protein Hox-B4\",\"id\":\"P17483\"},{\"label\":\"LIM/homeobox protein Lhx1\",\"id\":\"P48742\"},{\"label\":\"Nephronectin\",\"id\":\"Q6UXI9\"},{\"label\":\"Paired box protein Pax-2\",\"id\":\"Q02962\"},{\"label\":\"Paired box protein Pax-8\",\"id\":\"Q06710\"},{\"label\":\"Placenta-specific gene 8 protein\",\"id\":\"Q9NZF1\"},{\"label\":\"Protein odd-skipped-related 1\",\"id\":\"Q8TAX0\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase receptor Ret\",\"id\":\"P07949\"},{\"label\":\"Protocadherin-19\",\"id\":\"Q8TAB3\"},{\"label\":\"Trans-acting T-cell-specific transcription factor GATA-3\",\"id\":\"P23771\"},{\"label\":\"WAP four-disulfide core domain protein 2\",\"id\":\"Q14508\"}]", "uniprot_id": "[\"P07949\",\"P09038\",\"P12644\",\"P17483\",\"P23771\",\"P31267\",\"P35222\",\"P47928\",\"P48742\",\"Q02962\",\"Q03112\",\"Q04743\",\"Q06710\",\"Q14508\",\"Q6UXI9\",\"Q8TAB3\",\"Q8TAX0\",\"Q9NZF1\"]", "gene_symbol": 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C1\",\"id\":\"Q04828\"},{\"label\":\"Aldo-keto reductase family 1 member C2\",\"id\":\"P52895\"},{\"label\":\"Aldo-keto reductase family 1 member C3\",\"id\":\"P42330\"},{\"label\":\"Aldo-keto reductase family 1 member C4\",\"id\":\"P17516\"},{\"label\":\"Aldo-keto reductase family 1 member D1\",\"id\":\"P51857\"},{\"label\":\"Alpha-methylacyl-CoA racemase\",\"id\":\"Q9UHK6\"},{\"label\":\"Cholesterol 24-hydroxylase\",\"id\":\"Q9Y6A2\"},{\"label\":\"Long-chain fatty acid transport protein 2\",\"id\":\"O14975\"},{\"label\":\"Long-chain fatty acid transport protein 5\",\"id\":\"Q9Y2P5\"},{\"label\":\"Sterol 26-hydroxylase, mitochondrial\",\"id\":\"Q02318\"}]", "uniprot_id": "[\"O14975\",\"P17516\",\"P42330\",\"P51857\",\"P52895\",\"Q02318\",\"Q04828\",\"Q9H2F3\",\"Q9NYL5\",\"Q9UHK6\",\"Q9UNU6\",\"Q9Y2P5\",\"Q9Y6A2\"]", "gene_symbol": 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beta\",\"id\":\"P06746\"},{\"label\":\"DNA repair nuclease/redox regulator APEX1\",\"id\":\"P27695\"}]", "uniprot_id": "[\"P06746\",\"P27695\"]", "gene_symbol": "[\"APE\",\"APE1\",\"APEX\",\"APEX1\",\"APX\",\"HAP1\",\"POLB\",\"REF1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "protein_name": "[{\"label\":\"Adenosine 5'-monophosphoramidase HINT1\",\"id\":\"P49773\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cyclin-dependent kinase inhibitor 2A\",\"id\":\"P42771\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"Hepatocyte growth factor receptor\",\"id\":\"P08581\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Paired amphipathic helix protein Sin3a\",\"id\":\"Q96ST3\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"},{\"label\":\"T-box transcription factor TBX2\",\"id\":\"Q13207\"},{\"label\":\"Transcription factor 7-like 1\",\"id\":\"Q9HCS4\"},{\"label\":\"Transcription factor 7-like 2\",\"id\":\"Q9NQB0\"},{\"label\":\"Transcription factor 7\",\"id\":\"P36402\"}]", "uniprot_id": "[\"P08581\",\"P14635\",\"P24385\",\"P24941\",\"P35222\",\"P36402\",\"P38936\",\"P42771\",\"P49773\",\"P53350\",\"Q13207\",\"Q13547\",\"Q96ST3\",\"Q9HCS4\",\"Q9NQB0\",\"Q9UJU2\"]", "gene_symbol": "[\"BCL1\",\"CAP20\",\"CCNB\",\"CCNB1\",\"CCND1\",\"CDK2\",\"CDKN1\",\"CDKN1A\",\"CDKN2\",\"CDKN2A\",\"CIP1\",\"CTNNB\",\"CTNNB1\",\"HDAC1\",\"HINT\",\"HINT1\",\"LEF1\",\"MDA6\",\"MET\",\"MTS1\",\"PIC1\",\"PKCI1\",\"PLK\",\"PLK1\",\"PRAD1\",\"PRKCNH1\",\"RPD3L1\",\"SDI1\",\"SIN3A\",\"TBX2\",\"TCF1\",\"TCF3\",\"TCF4\",\"TCF7\",\"TCF7L1\",\"TCF7L2\",\"WAF1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "protein_name": "[{\"label\":\"APC membrane recruitment protein 1\",\"id\":\"Q5JTC6\"},{\"label\":\"Adenomatous polyposis coli protein\",\"id\":\"P25054\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Casein kinase I isoform alpha\",\"id\":\"P48729\"},{\"label\":\"Casein kinase I isoform gamma-2\",\"id\":\"P78368\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Frizzled-1\",\"id\":\"Q9UP38\"},{\"label\":\"Frizzled-2\",\"id\":\"Q14332\"},{\"label\":\"Frizzled-5\",\"id\":\"Q13467\"},{\"label\":\"GSK-3-binding protein FRAT2\",\"id\":\"O75474\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Low-density lipoprotein receptor-related protein 5\",\"id\":\"O75197\"},{\"label\":\"Low-density lipoprotein receptor-related protein 6\",\"id\":\"O75581\"},{\"label\":\"Protein 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56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O14640\",\"O14641\",\"O15169\",\"O75197\",\"O75474\",\"O75581\",\"P04628\",\"P25054\",\"P30153\",\"P30154\",\"P35222\",\"P48729\",\"P49841\",\"P56704\",\"P62714\",\"P67775\",\"P78368\",\"Q03135\",\"Q13362\",\"Q13467\",\"Q14332\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\",\"Q92837\",\"Q92997\",\"Q93098\",\"Q9H1J5\",\"Q9UP38\"]", "gene_symbol": 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coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Nuclear receptor coactivator 6\",\"id\":\"Q14686\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Paired amphipathic helix protein Sin3a\",\"id\":\"Q96ST3\"},{\"label\":\"Peroxisome proliferator-activated receptor alpha\",\"id\":\"Q07869\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3\",\"id\":\"Q6STE5\"},{\"label\":\"Trimethylguanosine synthase\",\"id\":\"Q96RS0\"}]", "uniprot_id": "[\"O15379\",\"O60907\",\"O75376\",\"P07148\",\"P19793\",\"Q07869\",\"Q14686\",\"Q15596\",\"Q15648\",\"Q15788\",\"Q3L8U1\",\"Q6STE5\",\"Q86X55\",\"Q92793\",\"Q96RS0\",\"Q96ST3\",\"Q9BYK8\",\"Q9BZK7\",\"Q9Y618\"]", "gene_symbol": 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isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Protein kinase C delta type\",\"id\":\"Q05655\"},{\"label\":\"Protein kinase C epsilon type\",\"id\":\"Q02156\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 12\",\"id\":\"Q05209\"}]", "uniprot_id": 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"[\"GGNT1\",\"GLCT1\",\"GLYT1\",\"MANEA\",\"MGAT\",\"MGAT1\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "Alkylating DNA damage induced by chemotherapeutic drugs", "protein_name": null, "uniprot_id": "[\"\"]", "gene_symbol": "[\"\"]", "gtc_id": "[\"G44151BN\"]" }, { "pathway_label": "Cyclin A/B1/B2 associated events during G2/M transition", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-A1\",\"id\":\"P78396\"},{\"label\":\"Cyclin-A2\",\"id\":\"P20248\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"Forkhead box protein M1\",\"id\":\"Q08050\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"G2/mitotic-specific cyclin-B2\",\"id\":\"O95067\"},{\"label\":\"Leucine carboxyl methyltransferase 1\",\"id\":\"Q9UIC8\"},{\"label\":\"M-phase inducer phosphatase 1\",\"id\":\"P30304\"},{\"label\":\"M-phase inducer phosphatase 2\",\"id\":\"P30305\"},{\"label\":\"M-phase inducer phosphatase 3\",\"id\":\"P30307\"},{\"label\":\"Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase\",\"id\":\"Q99640\"},{\"label\":\"Protein phosphatase methylesterase 1\",\"id\":\"Q9Y570\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform\",\"id\":\"P63151\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta\",\"id\":\"Q9Y5P8\"},{\"label\":\"Wee1-like protein kinase\",\"id\":\"P30291\"}]", "uniprot_id": "[\"O14980\",\"O95067\",\"P06493\",\"P14635\",\"P20248\",\"P24941\",\"P30153\",\"P30154\",\"P30291\",\"P30304\",\"P30305\",\"P30307\",\"P50613\",\"P51946\",\"P51948\",\"P53350\",\"P62714\",\"P63151\",\"P67775\",\"P78396\",\"Q08050\",\"Q99640\",\"Q9UIC8\",\"Q9Y570\",\"Q9Y5P8\"]", "gene_symbol": 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3\",\"id\":\"Q15054\"},{\"label\":\"DNA polymerase delta subunit 4\",\"id\":\"Q9HCU8\"},{\"label\":\"DNA primase large subunit\",\"id\":\"P49643\"},{\"label\":\"DNA primase small subunit\",\"id\":\"P49642\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"}]", "uniprot_id": "[\"P09884\",\"P12004\",\"P18858\",\"P28340\",\"P49005\",\"P49642\",\"P49643\",\"Q14181\",\"Q15054\",\"Q9HCU8\"]", "gene_symbol": "[\"KIAA0039\",\"LIG1\",\"PCNA\",\"POLA\",\"POLA1\",\"POLA2\",\"POLD\",\"POLD1\",\"POLD2\",\"POLD3\",\"POLD4\",\"POLDS\",\"PRIM1\",\"PRIM2\",\"PRIM2A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of the Early Elongation Complex", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Negative elongation factor A\",\"id\":\"Q9H3P2\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"},{\"label\":\"Negative elongation factor C/D\",\"id\":\"Q8IXH7\"},{\"label\":\"Negative elongation factor E\",\"id\":\"P18615\"},{\"label\":\"Nuclear cap-binding protein subunit 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domain-containing adapter protein 2\",\"id\":\"Q9UQB8\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Cytoplasmic FMR1-interacting protein 1\",\"id\":\"Q7L576\"},{\"label\":\"Cytoplasmic FMR1-interacting protein 2\",\"id\":\"Q96F07\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"NCK-interacting protein with SH3 domain\",\"id\":\"Q9NZQ3\"},{\"label\":\"Nck-associated protein 1-like\",\"id\":\"P55160\"},{\"label\":\"Nck-associated protein 1\",\"id\":\"Q9Y2A7\"},{\"label\":\"Protein BRICK1\",\"id\":\"Q8WUW1\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"SH2/SH3 adapter protein NCK1\",\"id\":\"P16333\"},{\"label\":\"Tyrosine-protein kinase ABL1\",\"id\":\"P00519\"},{\"label\":\"Tyrosine-protein kinase 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4A-III\",\"id\":\"P38919\"},{\"label\":\"Histone RNA hairpin-binding protein\",\"id\":\"Q14493\"},{\"label\":\"Leucine zipper protein 4\",\"id\":\"Q9P127\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Poly(A) polymerase alpha\",\"id\":\"P51003\"},{\"label\":\"Polyadenylate-binding protein 2\",\"id\":\"Q86U42\"},{\"label\":\"Polymerase delta-interacting protein 3\",\"id\":\"Q9BY77\"},{\"label\":\"Polyribonucleotide 5'-hydroxyl-kinase Clp1\",\"id\":\"Q92989\"},{\"label\":\"Pre-mRNA 3'-end-processing factor FIP1\",\"id\":\"Q6UN15\"},{\"label\":\"Pre-mRNA cleavage complex 2 protein Pcf11\",\"id\":\"O94913\"},{\"label\":\"Pre-mRNA-processing factor 17\",\"id\":\"O60508\"},{\"label\":\"Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16\",\"id\":\"Q92620\"},{\"label\":\"Pre-mRNA-splicing factor SLU7\",\"id\":\"O95391\"},{\"label\":\"Protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "FGFR3b ligand binding and activation", "protein_name": "[{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"}]", "uniprot_id": "[\"O76093\",\"P05230\",\"P31371\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF18\",\"FGF20\",\"FGF9\",\"FGFA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "protein_name": "[{\"label\":\"Apoptosis regulator BAX\",\"id\":\"Q07812\"},{\"label\":\"Apoptosis-stimulating of p53 protein 1\",\"id\":\"Q96KQ4\"},{\"label\":\"Apoptosis-stimulating of p53 protein 2\",\"id\":\"Q13625\"},{\"label\":\"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like\",\"id\":\"O60238\"},{\"label\":\"BH3-interacting domain death agonist\",\"id\":\"P55957\"},{\"label\":\"Bcl-2-binding component 3, isoforms 1/2\",\"id\":\"Q9BXH1\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Ferroptosis suppressor protein 1\",\"id\":\"Q9BRQ8\"},{\"label\":\"Metalloreductase STEAP3\",\"id\":\"Q658P3\"},{\"label\":\"PRELI domain containing protein 3A\",\"id\":\"Q96N28\"},{\"label\":\"PRELI domain-containing protein 1, mitochondrial\",\"id\":\"Q9Y255\"},{\"label\":\"Phorbol-12-myristate-13-acetate-induced protein 1\",\"id\":\"Q13794\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"TP53-regulated inhibitor of apoptosis 1\",\"id\":\"O43715\"},{\"label\":\"Tumor protein 63\",\"id\":\"Q9H3D4\"},{\"label\":\"Tumor protein p53-inducible nuclear protein 1\",\"id\":\"Q96A56\"},{\"label\":\"Tumor protein p73\",\"id\":\"O15350\"},{\"label\":\"Zinc finger protein 420\",\"id\":\"Q8TAQ5\"},{\"label\":\"p53-regulated apoptosis-inducing protein 1\",\"id\":\"Q9HCN2\"}]", "uniprot_id": "[\"O15350\",\"O43715\",\"O60238\",\"P04637\",\"P55957\",\"Q07812\",\"Q13315\",\"Q13625\",\"Q13794\",\"Q658P3\",\"Q8TAQ5\",\"Q92793\",\"Q96A56\",\"Q96KQ4\",\"Q96N28\",\"Q9BRQ8\",\"Q9BXH1\",\"Q9H3D4\",\"Q9HCN2\",\"Q9Y255\"]", "gene_symbol": "[\"15E1.1\",\"AIFM2\",\"AMID\",\"ASPP1\",\"ASPP2\",\"ATM\",\"BAX\",\"BBC3\",\"BBP\",\"BCL2L4\",\"BID\",\"BNIP3A\",\"BNIP3H\",\"BNIP3L\",\"C18orf43\",\"CBP\",\"CREBBP\",\"KET\",\"KIAA0771\",\"NIX\",\"NOXA\",\"P53\",\"P53DINP1\",\"P63\",\"P73\",\"P73H\",\"P73L\",\"PMAIP1\",\"PPP1R13B\",\"PRELI\",\"PRELID1\",\"PRELID3A\",\"PRG3\",\"PUMA\",\"SIP\",\"SLMO1\",\"STEAP3\",\"TP53\",\"TP53AIP1\",\"TP53BP2\",\"TP53INP1\",\"TP63\",\"TP73\",\"TP73L\",\"TRIAP1\",\"TSAP6\",\"ZNF420\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcriptional Regulation by MECP2", "protein_name": "[{\"label\":\"Guanidinoacetate N-methyltransferase\",\"id\":\"Q14353\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"Microprocessor complex subunit DGCR8\",\"id\":\"Q8WYQ5\"},{\"label\":\"Myelin-associated oligodendrocyte basic protein\",\"id\":\"Q13875\"},{\"label\":\"Parvalbumin alpha\",\"id\":\"P20472\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN\",\"id\":\"P60484\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Serine/threonine-protein kinase Sgk1\",\"id\":\"O00141\"},{\"label\":\"Transcription factor SOX-2\",\"id\":\"P48431\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"}]", "uniprot_id": "[\"O00141\",\"P20472\",\"P48431\",\"P51617\",\"P60484\",\"Q13875\",\"Q14353\",\"Q8NDV7\",\"Q8WYQ5\",\"Q9H9G7\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9UPQ9\"]", "gene_symbol": "[\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"C22orf12\",\"CAGH26\",\"DGCR8\",\"DGCRK6\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"GAMT\",\"IRAK\",\"IRAK1\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"KIAA1631\",\"MMAC1\",\"MOBP\",\"MOV10\",\"PTEN\",\"PVALB\",\"SGK\",\"SGK1\",\"SOX2\",\"TEP1\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SARS-CoV-2 modulates autophagy", "protein_name": "[{\"label\":\"Elongation factor Tu, mitochondrial\",\"id\":\"P49411\"},{\"label\":\"Membrane protein\",\"id\":\"P0DTC5\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 3B\",\"id\":\"Q9GZQ8\"},{\"label\":\"ORF3a protein\",\"id\":\"P0DTC3\"},{\"label\":\"ORF7a protein\",\"id\":\"P0DTC7\"},{\"label\":\"UV radiation resistance-associated gene protein\",\"id\":\"Q9P2Y5\"},{\"label\":\"Vacuolar protein sorting-associated protein 11 homolog\",\"id\":\"Q9H270\"},{\"label\":\"Vacuolar protein sorting-associated protein 16 homolog\",\"id\":\"Q9H269\"},{\"label\":\"Vacuolar protein sorting-associated protein 18 homolog\",\"id\":\"Q9P253\"},{\"label\":\"Vacuolar protein sorting-associated protein 33A\",\"id\":\"Q96AX1\"},{\"label\":\"Vacuolar protein sorting-associated protein 33B\",\"id\":\"Q9H267\"},{\"label\":\"Vacuolar protein sorting-associated protein 41 homolog\",\"id\":\"P49754\"},{\"label\":\"Vacuolar protein sorting-associated protein 45\",\"id\":\"Q9NRW7\"},{\"label\":\"Vam6/Vps39-like protein\",\"id\":\"Q96JC1\"}]", "uniprot_id": "[\"P0DTC3\",\"P0DTC5\",\"P0DTC7\",\"P49411\",\"P49754\",\"Q96AX1\",\"Q96JC1\",\"Q9GZQ8\",\"Q9H267\",\"Q9H269\",\"Q9H270\",\"Q9NRW7\",\"Q9P253\",\"Q9P2Y5\"]", "gene_symbol": 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7\",\"id\":\"Q11130\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6\",\"id\":\"Q969X2\"},{\"label\":\"Beta-1,3-galactosyltransferase 1\",\"id\":\"Q9Y5Z6\"},{\"label\":\"Beta-1,3-galactosyltransferase 2\",\"id\":\"O43825\"},{\"label\":\"Beta-1,3-galactosyltransferase 4\",\"id\":\"O96024\"},{\"label\":\"Beta-1,3-galactosyltransferase 5\",\"id\":\"Q9Y2C3\"},{\"label\":\"Beta-1,4 N-acetylgalactosaminyltransferase 2\",\"id\":\"Q8NHY0\"},{\"label\":\"CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase\",\"id\":\"Q11203\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4\",\"id\":\"Q11206\"},{\"label\":\"Galactoside alpha-(1,2)-fucosyltransferase 2\",\"id\":\"Q10981\"},{\"label\":\"Type 2 lactosamine alpha-2,3-sialyltransferase\",\"id\":\"Q9Y274\"}]", "uniprot_id": 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"[\"BHLHE73\",\"BHLHE78\",\"EPAS1\",\"FIH1\",\"HIF1A\",\"HIF1AN\",\"HIF2A\",\"MOP1\",\"MOP2\",\"PASD2\",\"PASD8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CD28 dependent Vav1 pathway", "protein_name": "[{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"T-cell-specific surface glycoprotein CD28\",\"id\":\"P10747\"},{\"label\":\"T-lymphocyte activation antigen CD80\",\"id\":\"P33681\"},{\"label\":\"T-lymphocyte activation antigen CD86\",\"id\":\"P42081\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"}]", "uniprot_id": "[\"O75914\",\"P06239\",\"P06241\",\"P10747\",\"P15498\",\"P33681\",\"P42081\",\"P60953\",\"P63000\",\"Q13153\",\"Q13177\"]", "gene_symbol": "[\"CD28\",\"CD28LG\",\"CD28LG1\",\"CD28LG2\",\"CD80\",\"CD86\",\"CDC42\",\"FYN\",\"LAB7\",\"LCK\",\"OPHN3\",\"PAK1\",\"PAK2\",\"PAK3\",\"RAC1\",\"TC25\",\"VAV\",\"VAV1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Budding", "protein_name": "[{\"label\":\"Hemagglutinin\",\"id\":\"P03452\"},{\"label\":\"Matrix protein 1\",\"id\":\"P03485\"},{\"label\":\"Matrix protein 2\",\"id\":\"P06821\"},{\"label\":\"Neuraminidase\",\"id\":\"P03468\"},{\"label\":\"Nuclear export protein\",\"id\":\"P03508\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"}]", "uniprot_id": "[\"P03428\",\"P03431\",\"P03433\",\"P03452\",\"P03466\",\"P03468\",\"P03485\",\"P03508\",\"P06821\"]", "gene_symbol": "[\"HA\",\"M\",\"NA\",\"NP\",\"NS\",\"PA\",\"PB1\",\"PB2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC7A7 causes lysinuric protein intolerance (LPI)", "protein_name": "[{\"label\":\"Amino acid transporter heavy chain SLC3A2\",\"id\":\"P08195\"},{\"label\":\"Y+L amino acid transporter 1\",\"id\":\"Q9UM01\"}]", "uniprot_id": "[\"P08195\",\"Q9UM01\"]", "gene_symbol": "[\"MDU1\",\"SLC3A2\",\"SLC7A7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Passive transport by Aquaporins", "protein_name": 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mitochondrial\",\"id\":\"P11177\"},{\"label\":\"Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial\",\"id\":\"Q8NCN5\"},{\"label\":\"Pyruvate dehydrogenase protein X component, mitochondrial\",\"id\":\"O00330\"},{\"label\":\"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial\",\"id\":\"Q15118\"},{\"label\":\"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial\",\"id\":\"Q15119\"},{\"label\":\"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial\",\"id\":\"Q15120\"},{\"label\":\"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial\",\"id\":\"Q16654\"},{\"label\":\"[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial\",\"id\":\"Q9P0J1\"},{\"label\":\"[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial\",\"id\":\"Q9P2J9\"}]", "uniprot_id": 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3\",\"id\":\"Q9Y6H6\"},{\"label\":\"Potassium voltage-gated channel subfamily E member 4\",\"id\":\"Q8WWG9\"},{\"label\":\"Potassium voltage-gated channel subfamily E regulatory beta subunit 5\",\"id\":\"Q9UJ90\"},{\"label\":\"Potassium voltage-gated channel subfamily KQT member 1\",\"id\":\"P51787\"},{\"label\":\"Voltage-gated inwardly rectifying potassium channel KCNH2\",\"id\":\"Q12809\"}]", "uniprot_id": "[\"P15382\",\"P22460\",\"P51787\",\"Q12809\",\"Q8WWG9\",\"Q99996\",\"Q9UJ90\",\"Q9Y6H6\",\"Q9Y6J6\"]", "gene_symbol": "[\"AKAP350\",\"AKAP450\",\"AKAP9\",\"AMMECR2\",\"ERG\",\"ERG1\",\"HERG\",\"KCNA5\",\"KCNA8\",\"KCNA9\",\"KCNE1\",\"KCNE1L\",\"KCNE2\",\"KCNE3\",\"KCNE4\",\"KCNE5\",\"KCNH2\",\"KCNQ1\",\"KIAA0803\",\"KVLQT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SUMOylation of DNA damage response and repair proteins", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Bifunctional 3'-5' exonuclease/ATP-dependent helicase 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ubiquitin-protein ligase HERC2\",\"id\":\"O95714\"},{\"label\":\"E3 ubiquitin-protein ligase RING1\",\"id\":\"Q06587\"},{\"label\":\"E3 ubiquitin-protein ligase RING2\",\"id\":\"Q99496\"},{\"label\":\"E3 ubiquitin-protein ligase RNF168\",\"id\":\"Q8IYW5\"},{\"label\":\"EP300-interacting inhibitor of differentiation 3\",\"id\":\"Q8N140\"},{\"label\":\"G/T mismatch-specific thymine DNA glycosylase\",\"id\":\"Q13569\"},{\"label\":\"Histone deacetylase 7\",\"id\":\"Q8WUI4\"},{\"label\":\"Mediator of DNA damage checkpoint protein 1\",\"id\":\"Q14676\"},{\"label\":\"Non-structural maintenance of chromosomes element 1 homolog\",\"id\":\"Q8WV22\"},{\"label\":\"Non-structural maintenance of chromosomes element 3 homolog\",\"id\":\"Q96MG7\"},{\"label\":\"Non-structural maintenance of chromosomes element 4 homolog A\",\"id\":\"Q9NXX6\"},{\"label\":\"Nuclear autoantigen Sp-100\",\"id\":\"P23497\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear 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"gtc_id": "[\"\"]" }, { "pathway_label": "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "protein_name": "[{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"Galectin-3\",\"id\":\"P17931\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor\",\"id\":\"P04141\"},{\"label\":\"Protein kinase C beta type\",\"id\":\"P05771\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"}]", "uniprot_id": "[\"P04141\",\"P05771\",\"P17931\",\"Q01196\",\"Q13951\",\"Q92793\"]", "gene_symbol": "[\"AML1\",\"CBFA2\",\"CBFB\",\"CBP\",\"CREBBP\",\"CSF2\",\"GMCSF\",\"LGALS3\",\"MAC2\",\"PKCB\",\"PRKCB\",\"PRKCB1\",\"RUNX1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FCERI mediated MAPK activation", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"1-phosphatidylinositol 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2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC17A5 causes Salla disease (SD) and ISSD", "protein_name": "[{\"label\":\"Sialin\",\"id\":\"Q9NRA2\"}]", "uniprot_id": "[\"Q9NRA2\"]", "gene_symbol": "[\"SLC17A5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)", "protein_name": "[{\"label\":\"Solute carrier family 22 member 12\",\"id\":\"Q96S37\"}]", "uniprot_id": "[\"Q96S37\"]", "gene_symbol": "[\"OATL4\",\"SLC22A12\",\"URAT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "OAS antiviral response", "protein_name": "[{\"label\":\"2',5'-phosphodiesterase 12\",\"id\":\"Q6L8Q7\"},{\"label\":\"2'-5'-oligoadenylate synthase 1\",\"id\":\"P00973\"},{\"label\":\"2'-5'-oligoadenylate synthase 2\",\"id\":\"P29728\"},{\"label\":\"2'-5'-oligoadenylate synthase 3\",\"id\":\"Q9Y6K5\"},{\"label\":\"2'-5'-oligoadenylate synthase-like protein\",\"id\":\"Q15646\"},{\"label\":\"2-5A-dependent ribonuclease\",\"id\":\"Q05823\"},{\"label\":\"ATP-binding cassette sub-family E member 1\",\"id\":\"P61221\"},{\"label\":\"Antiviral innate immune response receptor RIG-I\",\"id\":\"O95786\"},{\"label\":\"Filamin-A\",\"id\":\"P21333\"},{\"label\":\"Protein VP3\",\"id\":\"B1NKT1\"}]", "uniprot_id": "[\"B1NKT1\",\"O95786\",\"P00973\",\"P21333\",\"P29728\",\"P61221\",\"Q05823\",\"Q15646\",\"Q6L8Q7\",\"Q9Y6K5\"]", "gene_symbol": "[\"ABCE1\",\"DDX58\",\"FLN\",\"FLN1\",\"FLNA\",\"OAS1\",\"OAS2\",\"OAS3\",\"OASL\",\"OIAS\",\"PDE12\",\"RIGI\",\"RLI\",\"RNASEL\",\"RNASEL1\",\"RNASELI\",\"RNS4\",\"RNS4I\",\"TRIP14\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "InlA-mediated entry of Listeria monocytogenes into host cells", "protein_name": "[{\"label\":\"Cadherin-1\",\"id\":\"P12830\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Catenin delta-1\",\"id\":\"O60716\"},{\"label\":\"E3 ubiquitin-protein ligase Hakai\",\"id\":\"Q75N03\"},{\"label\":\"Internalin A\",\"id\":\"P0DJM0\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O60716\",\"P0CG47\",\"P0CG48\",\"P0DJM0\",\"P12830\",\"P12931\",\"P35222\",\"P62979\",\"P62987\",\"Q75N03\"]", "gene_symbol": "[\"CBLL1\",\"CDH1\",\"CDHE\",\"CTNNB\",\"CTNNB1\",\"CTNND1\",\"HAKAI\",\"KIAA0384\",\"RNF188\",\"RPS27A\",\"SRC\",\"SRC1\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"UVO\",\"inlA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 9\",\"id\":\"O60706\"},{\"label\":\"ATP-sensitive inward rectifier potassium channel 11\",\"id\":\"Q14654\"}]", "uniprot_id": "[\"O60706\",\"Q14654\"]", "gene_symbol": "[\"ABCC9\",\"KCNJ11\",\"SUR2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Sphingolipid catabolism", "protein_name": "[{\"label\":\"Aldehyde dehydrogenase family 3 member B1\",\"id\":\"P43353\"},{\"label\":\"Aldehyde dehydrogenase family 3 member B2\",\"id\":\"P48448\"},{\"label\":\"Alkaline ceramidase 1\",\"id\":\"Q8TDN7\"},{\"label\":\"Alkaline ceramidase 2\",\"id\":\"Q5QJU3\"},{\"label\":\"Alkaline ceramidase 3\",\"id\":\"Q9NUN7\"},{\"label\":\"Phospholipid phosphatase 1\",\"id\":\"O14494\"},{\"label\":\"Phospholipid phosphatase 2\",\"id\":\"O43688\"},{\"label\":\"Phospholipid phosphatase 3\",\"id\":\"O14495\"},{\"label\":\"Sphingosine-1-phosphate lyase 1\",\"id\":\"O95470\"},{\"label\":\"Sphingosine-1-phosphate phosphatase 1\",\"id\":\"Q9BX95\"},{\"label\":\"Sphingosine-1-phosphate phosphatase 2\",\"id\":\"Q8IWX5\"}]", "uniprot_id": "[\"O14494\",\"O14495\",\"O43688\",\"O95470\",\"P43353\",\"P48448\",\"Q5QJU3\",\"Q8IWX5\",\"Q8TDN7\",\"Q9BX95\",\"Q9NUN7\"]", "gene_symbol": "[\"ACER1\",\"ACER2\",\"ACER3\",\"ALDH3B1\",\"ALDH3B2\",\"ALDH7\",\"ALDH8\",\"APHC\",\"ASAH3\",\"ASAH3L\",\"KIAA1252\",\"LPP1\",\"LPP2\",\"LPP3\",\"PHCA\",\"PLPP1\",\"PLPP2\",\"PLPP3\",\"PPAP2A\",\"PPAP2B\",\"PPAP2C\",\"SGPL1\",\"SGPP1\",\"SGPP2\",\"SPP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SUMOylation of transcription factors", "protein_name": "[{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"E3 SUMO-protein ligase PIAS1\",\"id\":\"O75925\"},{\"label\":\"E3 SUMO-protein ligase PIAS3\",\"id\":\"Q9Y6X2\"},{\"label\":\"E3 SUMO-protein ligase PIAS4\",\"id\":\"Q8N2W9\"},{\"label\":\"E3 ubiquitin-protein ligase Mdm2\",\"id\":\"Q00987\"},{\"label\":\"Forkhead box protein L2\",\"id\":\"P58012\"},{\"label\":\"Hypermethylated in cancer 1 protein\",\"id\":\"Q14526\"},{\"label\":\"Metastasis-associated protein MTA1\",\"id\":\"Q13330\"},{\"label\":\"Microphthalmia-associated transcription factor\",\"id\":\"O75030\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"},{\"label\":\"Small ubiquitin-related modifier 2\",\"id\":\"P61956\"},{\"label\":\"Small ubiquitin-related modifier 3\",\"id\":\"P55854\"},{\"label\":\"TP53-binding protein 1\",\"id\":\"Q12888\"},{\"label\":\"Transcription factor AP-2 gamma\",\"id\":\"Q92754\"},{\"label\":\"Transcription factor AP-2-beta\",\"id\":\"Q92481\"},{\"label\":\"Transcription factor Sp3\",\"id\":\"Q02447\"},{\"label\":\"Tumor suppressor ARF\",\"id\":\"Q8N726\"}]", "uniprot_id": "[\"O75030\",\"O75925\",\"P04637\",\"P55854\",\"P58012\",\"P61956\",\"P63165\",\"P63279\",\"Q00987\",\"Q02447\",\"Q12888\",\"Q13330\",\"Q14526\",\"Q8N2W9\",\"Q8N726\",\"Q92481\",\"Q92754\",\"Q9Y6X2\"]", "gene_symbol": 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"[\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAMK1\",\"CAMKK1\",\"CAMKK2\",\"CAMKKA\",\"CAMKKB\",\"GIT1\",\"KIAA0787\",\"RAC1\",\"TC25\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective AHCY causes HMAHCHD", "protein_name": "[{\"label\":\"Adenosylhomocysteinase\",\"id\":\"P23526\"}]", "uniprot_id": "[\"P23526\"]", "gene_symbol": "[\"AHCY\",\"SAHH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Vitamin B2 (riboflavin) metabolism", "protein_name": "[{\"label\":\"Ectonucleotide pyrophosphatase/phosphodiesterase family member 1\",\"id\":\"P22413\"},{\"label\":\"FAD synthase\",\"id\":\"Q8NFF5\"},{\"label\":\"Riboflavin kinase\",\"id\":\"Q969G6\"},{\"label\":\"Solute carrier family 52, riboflavin transporter, member 1\",\"id\":\"Q9NWF4\"},{\"label\":\"Solute carrier family 52, riboflavin transporter, member 2\",\"id\":\"Q9HAB3\"},{\"label\":\"Solute carrier family 52, riboflavin transporter, member 3\",\"id\":\"Q9NQ40\"},{\"label\":\"Tartrate-resistant acid phosphatase type 5\",\"id\":\"P13686\"}]", "uniprot_id": "[\"P13686\",\"P22413\",\"Q8NFF5\",\"Q969G6\",\"Q9HAB3\",\"Q9NQ40\",\"Q9NWF4\"]", "gene_symbol": "[\"ACP5\",\"C20orf54\",\"ENPP1\",\"FLAD1\",\"GPR172A\",\"GPR172B\",\"M6S1\",\"NPPS\",\"PAR1\",\"PAR2\",\"PC1\",\"PDNP1\",\"RFK\",\"RFT1\",\"RFT2\",\"RFT3\",\"RFVT3\",\"SLC52A1\",\"SLC52A2\",\"SLC52A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Protein repair", "protein_name": "[{\"label\":\"Methionine-R-sulfoxide reductase B1\",\"id\":\"Q9NZV6\"},{\"label\":\"Methionine-R-sulfoxide reductase B2, mitochondrial\",\"id\":\"Q9Y3D2\"},{\"label\":\"Methionine-R-sulfoxide reductase B3\",\"id\":\"Q8IXL7\"},{\"label\":\"Mitochondrial peptide methionine sulfoxide reductase\",\"id\":\"Q9UJ68\"},{\"label\":\"Protein-L-isoaspartate(D-aspartate) O-methyltransferase\",\"id\":\"P22061\"},{\"label\":\"Thioredoxin\",\"id\":\"P10599\"}]", "uniprot_id": "[\"P10599\",\"P22061\",\"Q8IXL7\",\"Q9NZV6\",\"Q9UJ68\",\"Q9Y3D2\"]", "gene_symbol": "[\"CBS-1\",\"MSRA\",\"MSRB\",\"MSRB1\",\"MSRB2\",\"MSRB3\",\"PCMT1\",\"SEPX1\",\"TRDX\",\"TRX\",\"TRX1\",\"TXN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)", "protein_name": "[{\"label\":\"Sodium-dependent dopamine transporter\",\"id\":\"Q01959\"}]", "uniprot_id": "[\"Q01959\"]", "gene_symbol": "[\"DAT1\",\"SLC6A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function", "protein_name": "[{\"label\":\"Complement component 1 Q subcomponent-binding protein, mitochondrial\",\"id\":\"Q07021\"},{\"label\":\"Tumor suppressor ARF\",\"id\":\"Q8N726\"}]", "uniprot_id": "[\"Q07021\",\"Q8N726\"]", "gene_symbol": "[\"C1QBP\",\"CDKN2\",\"CDKN2A\",\"GC1QBP\",\"HABP1\",\"MLM\",\"SF2P32\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "gilteritinib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis And Processing Of GAG, GAGPOL Polyproteins", "protein_name": "[{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"}]", "uniprot_id": "[\"P04591\"]", "gene_symbol": "[\"gag\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "protein_name": "[{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"Apoptosis regulator Bcl-2\",\"id\":\"P10415\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"ETS domain-containing protein Elk-1\",\"id\":\"P19419\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Epigen\",\"id\":\"Q6UW88\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Forkhead box protein O3\",\"id\":\"O43524\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Protein c-Fos\",\"id\":\"P01100\"},{\"label\":\"Protransforming growth factor alpha\",\"id\":\"P01135\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Serine/threonine-protein kinase Kist\",\"id\":\"Q8TAS1\"},{\"label\":\"Serum response factor\",\"id\":\"P11831\"}]", "uniprot_id": 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with thrombospondin motifs 2\",\"id\":\"O95450\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 3\",\"id\":\"O15072\"},{\"label\":\"Bone morphogenetic protein 1\",\"id\":\"P13497\"},{\"label\":\"Cartilage-associated protein\",\"id\":\"O75718\"},{\"label\":\"Collagen alpha-1(I) chain\",\"id\":\"P02452\"},{\"label\":\"Collagen alpha-1(II) chain\",\"id\":\"P02458\"},{\"label\":\"Collagen alpha-1(III) chain\",\"id\":\"P02461\"},{\"label\":\"Collagen alpha-1(IV) chain\",\"id\":\"P02462\"},{\"label\":\"Collagen alpha-1(IX) chain\",\"id\":\"P20849\"},{\"label\":\"Collagen alpha-1(V) chain\",\"id\":\"P20908\"},{\"label\":\"Collagen alpha-1(VI) chain\",\"id\":\"P12109\"},{\"label\":\"Collagen alpha-1(VII) chain\",\"id\":\"Q02388\"},{\"label\":\"Collagen alpha-1(VIII) chain\",\"id\":\"P27658\"},{\"label\":\"Collagen alpha-1(X) chain\",\"id\":\"Q03692\"},{\"label\":\"Collagen alpha-1(XI) chain\",\"id\":\"P12107\"},{\"label\":\"Collagen alpha-1(XII) chain\",\"id\":\"Q99715\"},{\"label\":\"Collagen alpha-1(XIII) chain\",\"id\":\"Q5TAT6\"},{\"label\":\"Collagen alpha-1(XIV) chain\",\"id\":\"Q05707\"},{\"label\":\"Collagen alpha-1(XIX) chain\",\"id\":\"Q14993\"},{\"label\":\"Collagen alpha-1(XV) chain\",\"id\":\"P39059\"},{\"label\":\"Collagen alpha-1(XVI) chain\",\"id\":\"Q07092\"},{\"label\":\"Collagen alpha-1(XVII) chain\",\"id\":\"Q9UMD9\"},{\"label\":\"Collagen alpha-1(XVIII) chain\",\"id\":\"P39060\"},{\"label\":\"Collagen alpha-1(XX) chain\",\"id\":\"Q9P218\"},{\"label\":\"Collagen alpha-1(XXI) chain\",\"id\":\"Q96P44\"},{\"label\":\"Collagen alpha-1(XXII) chain\",\"id\":\"Q8NFW1\"},{\"label\":\"Collagen alpha-1(XXIII) chain\",\"id\":\"Q86Y22\"},{\"label\":\"Collagen alpha-1(XXIV) chain\",\"id\":\"Q17RW2\"},{\"label\":\"Collagen alpha-1(XXV) chain\",\"id\":\"Q9BXS0\"},{\"label\":\"Collagen alpha-1(XXVI) chain\",\"id\":\"Q96A83\"},{\"label\":\"Collagen alpha-1(XXVII) chain\",\"id\":\"Q8IZC6\"},{\"label\":\"Collagen alpha-1(XXVIII) chain\",\"id\":\"Q2UY09\"},{\"label\":\"Collagen alpha-2(I) chain\",\"id\":\"P08123\"},{\"label\":\"Collagen alpha-2(IV) chain\",\"id\":\"P08572\"},{\"label\":\"Collagen alpha-2(IX) chain\",\"id\":\"Q14055\"},{\"label\":\"Collagen alpha-2(V) chain\",\"id\":\"P05997\"},{\"label\":\"Collagen alpha-2(VI) chain\",\"id\":\"P12110\"},{\"label\":\"Collagen alpha-2(VIII) chain\",\"id\":\"P25067\"},{\"label\":\"Collagen alpha-2(XI) chain\",\"id\":\"P13942\"},{\"label\":\"Collagen alpha-3(IV) chain\",\"id\":\"Q01955\"},{\"label\":\"Collagen alpha-3(IX) chain\",\"id\":\"Q14050\"},{\"label\":\"Collagen alpha-3(V) chain\",\"id\":\"P25940\"},{\"label\":\"Collagen alpha-3(VI) chain\",\"id\":\"P12111\"},{\"label\":\"Collagen alpha-4(IV) chain\",\"id\":\"P53420\"},{\"label\":\"Collagen alpha-5(IV) chain\",\"id\":\"P29400\"},{\"label\":\"Collagen alpha-5(VI) chain\",\"id\":\"A8TX70\"},{\"label\":\"Collagen alpha-6(IV) chain\",\"id\":\"Q14031\"},{\"label\":\"Collagen alpha-6(VI) chain\",\"id\":\"A6NMZ7\"},{\"label\":\"Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3\",\"id\":\"O60568\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase B\",\"id\":\"P23284\"},{\"label\":\"Procollagen C-endopeptidase enhancer 1\",\"id\":\"Q15113\"},{\"label\":\"Procollagen C-endopeptidase enhancer 2\",\"id\":\"Q9UKZ9\"},{\"label\":\"Procollagen galactosyltransferase 1\",\"id\":\"Q8NBJ5\"},{\"label\":\"Procollagen galactosyltransferase 2\",\"id\":\"Q8IYK4\"},{\"label\":\"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1\",\"id\":\"Q02809\"},{\"label\":\"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2\",\"id\":\"O00469\"},{\"label\":\"Prolyl 3-hydroxylase 1\",\"id\":\"Q32P28\"},{\"label\":\"Prolyl 3-hydroxylase 2\",\"id\":\"Q8IVL5\"},{\"label\":\"Prolyl 3-hydroxylase 3\",\"id\":\"Q8IVL6\"},{\"label\":\"Prolyl 4-hydroxylase subunit alpha-1\",\"id\":\"P13674\"},{\"label\":\"Prolyl 4-hydroxylase subunit alpha-2\",\"id\":\"O15460\"},{\"label\":\"Prolyl 4-hydroxylase subunit alpha-3\",\"id\":\"Q7Z4N8\"},{\"label\":\"Protein disulfide-isomerase\",\"id\":\"P07237\"},{\"label\":\"Serpin H1\",\"id\":\"P50454\"},{\"label\":\"Tolloid-like protein 1\",\"id\":\"O43897\"},{\"label\":\"Tolloid-like protein 2\",\"id\":\"Q9Y6L7\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of PIPs at the ER membrane", "protein_name": "[{\"label\":\"Myotubularin-related protein 5\",\"id\":\"O95248\"},{\"label\":\"Phosphatidylinositol 4-kinase alpha\",\"id\":\"P42356\"},{\"label\":\"Phosphatidylinositol 4-kinase type 2-beta\",\"id\":\"Q8TCG2\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2\",\"id\":\"Q13614\"},{\"label\":\"Phosphatidylinositol-3-phosphatase SAC1\",\"id\":\"Q9NTJ5\"}]", "uniprot_id": "[\"O95248\",\"P42356\",\"Q13614\",\"Q8TCG2\",\"Q9NTJ5\"]", "gene_symbol": "[\"KIAA0851\",\"KIAA1073\",\"MTMR2\",\"MTMR5\",\"PI4K2B\",\"PI4KA\",\"PIK4\",\"PIK4CA\",\"SAC1\",\"SACM1L\",\"SBF1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of TC-NER Pre-Incision Complex", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"COP9 signalosome complex subunit 1\",\"id\":\"Q13098\"},{\"label\":\"COP9 signalosome complex subunit 2\",\"id\":\"P61201\"},{\"label\":\"COP9 signalosome complex subunit 3\",\"id\":\"Q9UNS2\"},{\"label\":\"COP9 signalosome complex subunit 4\",\"id\":\"Q9BT78\"},{\"label\":\"COP9 signalosome complex subunit 5\",\"id\":\"Q92905\"},{\"label\":\"COP9 signalosome complex subunit 6\",\"id\":\"Q7L5N1\"},{\"label\":\"COP9 signalosome complex subunit 7a\",\"id\":\"Q9UBW8\"},{\"label\":\"COP9 signalosome complex subunit 7b\",\"id\":\"Q9H9Q2\"},{\"label\":\"COP9 signalosome complex subunit 8\",\"id\":\"Q99627\"},{\"label\":\"Cullin-4A\",\"id\":\"Q13619\"},{\"label\":\"Cullin-4B\",\"id\":\"Q13620\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA damage-binding protein 1\",\"id\":\"Q16531\"},{\"label\":\"DNA excision repair protein ERCC-6\",\"id\":\"Q03468\"},{\"label\":\"DNA excision repair protein ERCC-8\",\"id\":\"Q13216\"},{\"label\":\"DNA repair protein complementing XP-A cells\",\"id\":\"P23025\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and 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"gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of MITF-M-dependent genes involved in pigmentation", "protein_name": "[{\"label\":\"5,6-dihydroxyindole-2-carboxylic acid oxidase\",\"id\":\"P17643\"},{\"label\":\"AT-rich interactive domain-containing protein 1A\",\"id\":\"O14497\"},{\"label\":\"AT-rich interactive domain-containing protein 1B\",\"id\":\"Q8NFD5\"},{\"label\":\"Actin, cytoplasmic 1\",\"id\":\"P60709\"},{\"label\":\"Actin-like protein 6A\",\"id\":\"O96019\"},{\"label\":\"B-cell CLL/lymphoma 7 protein family member A\",\"id\":\"Q4VC05\"},{\"label\":\"B-cell CLL/lymphoma 7 protein family member B\",\"id\":\"Q9BQE9\"},{\"label\":\"B-cell CLL/lymphoma 7 protein family member C\",\"id\":\"Q8WUZ0\"},{\"label\":\"Calcium-responsive transactivator\",\"id\":\"O75177\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"G-protein coupled receptor 143\",\"id\":\"P51810\"},{\"label\":\"Interferon regulatory factor 4\",\"id\":\"Q15306\"},{\"label\":\"L-dopachrome tautomerase\",\"id\":\"P40126\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Melanocyte protein PMEL\",\"id\":\"P40967\"},{\"label\":\"Melanoma antigen recognized by T-cells 1\",\"id\":\"Q16655\"},{\"label\":\"Melanophilin\",\"id\":\"Q9BV36\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Probable global transcription activator SNF2L2\",\"id\":\"P51531\"},{\"label\":\"Protein SSXT\",\"id\":\"Q15532\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"Rab effector MyRIP\",\"id\":\"Q8NFW9\"},{\"label\":\"Ras-related protein Rab-27A\",\"id\":\"P51159\"},{\"label\":\"SWI/SNF complex subunit SMARCC1\",\"id\":\"Q92922\"},{\"label\":\"SWI/SNF complex subunit SMARCC2\",\"id\":\"Q8TAQ2\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1\",\"id\":\"Q12824\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1\",\"id\":\"Q96GM5\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2\",\"id\":\"Q92925\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3\",\"id\":\"Q6STE5\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1\",\"id\":\"Q969G3\"},{\"label\":\"Synaptotagmin-like protein 2\",\"id\":\"Q9HCH5\"},{\"label\":\"Transcription activator BRG1\",\"id\":\"P51532\"},{\"label\":\"Transcription factor AP-2-alpha\",\"id\":\"P05549\"},{\"label\":\"Transcription factor SOX-10\",\"id\":\"P56693\"},{\"label\":\"Tyrosinase\",\"id\":\"P14679\"},{\"label\":\"Unconventional myosin-Va\",\"id\":\"Q9Y4I1\"},{\"label\":\"Upstream stimulatory factor 1\",\"id\":\"P22415\"},{\"label\":\"Zinc finger protein DPF3\",\"id\":\"Q92784\"},{\"label\":\"Zinc finger protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Metabolism of ingested SeMet, Sec, MeSec into H2Se", "protein_name": "[{\"label\":\"Adenosylhomocysteinase\",\"id\":\"P23526\"},{\"label\":\"Cystathionine beta-synthase\",\"id\":\"P35520\"},{\"label\":\"Cystathionine gamma-lyase\",\"id\":\"P32929\"},{\"label\":\"Glycine N-methyltransferase\",\"id\":\"Q14749\"},{\"label\":\"Histamine N-methyltransferase\",\"id\":\"P50135\"},{\"label\":\"Nicotinamide N-methyltransferase\",\"id\":\"P40261\"},{\"label\":\"S-adenosylmethionine synthase isoform type-1\",\"id\":\"Q00266\"},{\"label\":\"Selenocysteine lyase\",\"id\":\"Q96I15\"}]", "uniprot_id": "[\"P23526\",\"P32929\",\"P35520\",\"P40261\",\"P50135\",\"Q00266\",\"Q14749\",\"Q96I15\"]", "gene_symbol": "[\"AHCY\",\"AMS1\",\"CBS\",\"CTH\",\"GNMT\",\"HNMT\",\"MAT1A\",\"MATA1\",\"NNMT\",\"SAHH\",\"SCL\",\"SCLY\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Translocation of ZAP-70 to Immunological synapse", "protein_name": "[{\"label\":\"HLA class II histocompatibility antigen, DP alpha 1 chain\",\"id\":\"P20036\"},{\"label\":\"HLA class II histocompatibility antigen, DP beta 1 chain\",\"id\":\"P04440\"},{\"label\":\"HLA class II histocompatibility antigen, DQ alpha 1 chain\",\"id\":\"P01909\"},{\"label\":\"HLA class II histocompatibility antigen, DQ alpha 2 chain\",\"id\":\"P01906\"},{\"label\":\"HLA class II histocompatibility antigen, DQ beta 1 chain\",\"id\":\"P01920\"},{\"label\":\"HLA class II histocompatibility antigen, DQ beta 2 chain\",\"id\":\"P05538\"},{\"label\":\"HLA class II histocompatibility antigen, DR alpha chain\",\"id\":\"P01903\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 3 chain\",\"id\":\"P79483\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 4 chain\",\"id\":\"P13762\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 5 chain\",\"id\":\"Q30154\"},{\"label\":\"HLA class II histocompatibility antigen, DRB1 beta chain\",\"id\":\"P01911\"},{\"label\":\"T cell receptor alpha chain constant\",\"id\":\"P01848\"},{\"label\":\"T cell receptor alpha variable 19\",\"id\":\"A0A0A6YYK7\"},{\"label\":\"T cell receptor alpha variable 29/delta variable 5\",\"id\":\"P04437\"},{\"label\":\"T cell receptor alpha variable 8-4\",\"id\":\"P01737\"},{\"label\":\"T cell receptor beta constant 1\",\"id\":\"P01850\"},{\"label\":\"T cell receptor beta variable 12-3\",\"id\":\"P01733\"},{\"label\":\"T cell receptor beta variable 7-9\",\"id\":\"P04435\"},{\"label\":\"T-cell surface glycoprotein CD3 delta chain\",\"id\":\"P04234\"},{\"label\":\"T-cell surface glycoprotein CD3 epsilon chain\",\"id\":\"P07766\"},{\"label\":\"T-cell surface glycoprotein CD3 gamma chain\",\"id\":\"P09693\"},{\"label\":\"T-cell surface glycoprotein CD4\",\"id\":\"P01730\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein kinase ZAP-70\",\"id\":\"P43403\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 22\",\"id\":\"Q9Y2R2\"}]", 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NRas\",\"id\":\"P01111\"},{\"label\":\"Neurofibromin\",\"id\":\"P21359\"},{\"label\":\"Sprouty-related, EVH1 domain-containing protein 1\",\"id\":\"Q7Z699\"},{\"label\":\"Sprouty-related, EVH1 domain-containing protein 2\",\"id\":\"Q7Z698\"},{\"label\":\"Sprouty-related, EVH1 domain-containing protein 3\",\"id\":\"Q2MJR0\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P21359\",\"Q2MJR0\",\"Q7Z698\",\"Q7Z699\"]", "gene_symbol": "[\"EVE-3\",\"HRAS\",\"HRAS1\",\"NF1\",\"NRAS\",\"SPRED1\",\"SPRED2\",\"SPRED3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "AUF1 (hnRNP D0) binds and destabilizes mRNA", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Eukaryotic translation initiation factor 4 gamma 1\",\"id\":\"Q04637\"},{\"label\":\"Heat shock 70 kDa protein 1A\",\"id\":\"P0DMV8\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Heat shock protein beta-1\",\"id\":\"P04792\"},{\"label\":\"Polyadenylate-binding protein 1\",\"id\":\"P11940\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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and RIN", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"GTP-binding protein Rit1\",\"id\":\"Q92963\"},{\"label\":\"GTP-binding protein Rit2\",\"id\":\"Q99578\"},{\"label\":\"High affinity nerve growth factor receptor\",\"id\":\"P04629\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"}]", "uniprot_id": "[\"P01138\",\"P04629\",\"P15056\",\"Q92963\",\"Q99578\"]", "gene_symbol": "[\"BRAF\",\"BRAF1\",\"MTC\",\"NGF\",\"NGFB\",\"NTRK1\",\"RAFB1\",\"RIBB\",\"RIN\",\"RIT\",\"RIT1\",\"RIT2\",\"ROC1\",\"ROC2\",\"TRK\",\"TRKA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CTNNB1 S37 mutants aren't phosphorylated", "protein_name": "[{\"label\":\"APC membrane recruitment protein 1\",\"id\":\"Q5JTC6\"},{\"label\":\"Adenomatous polyposis coli protein\",\"id\":\"P25054\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Casein kinase I isoform alpha\",\"id\":\"P48729\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O15169\",\"P25054\",\"P30153\",\"P30154\",\"P35222\",\"P48729\",\"P49841\",\"P62714\",\"P67775\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\"]", "gene_symbol": "[\"AMER1\",\"APC\",\"AXIN\",\"AXIN1\",\"CSNK1A1\",\"CTNNB\",\"CTNNB1\",\"DP2.5\",\"FAM123B\",\"GSK3B\",\"KIAA0044\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"WTX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Chylomicron remodeling", "protein_name": "[{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Apolipoprotein A-II\",\"id\":\"P02652\"},{\"label\":\"Apolipoprotein A-IV\",\"id\":\"P06727\"},{\"label\":\"Apolipoprotein A-V\",\"id\":\"Q6Q788\"},{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Apolipoprotein C-II\",\"id\":\"P02655\"},{\"label\":\"Apolipoprotein C-III\",\"id\":\"P02656\"},{\"label\":\"Apolipoprotein E\",\"id\":\"P02649\"},{\"label\":\"Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1\",\"id\":\"Q8IV16\"},{\"label\":\"Lipoprotein lipase\",\"id\":\"P06858\"}]", "uniprot_id": "[\"P02647\",\"P02649\",\"P02652\",\"P02655\",\"P02656\",\"P04114\",\"P06727\",\"P06858\",\"Q6Q788\",\"Q8IV16\"]", "gene_symbol": "[\"APC2\",\"APOA1\",\"APOA2\",\"APOA4\",\"APOA5\",\"APOB\",\"APOC2\",\"APOC3\",\"APOE\",\"GPIHBP1\",\"HBP1\",\"LIPD\",\"LPL\",\"RAP3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Maturation of protein E", "protein_name": "[{\"label\":\"Envelope small membrane protein\",\"id\":\"P0DTC4\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"P0CG47\",\"P0CG48\",\"P0DTC4\",\"P62979\",\"P62987\"]", "gene_symbol": "[\"E\",\"RPS27A\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Assembly and cell surface presentation of NMDA receptors", "protein_name": "[{\"label\":\"Alpha-actinin-2\",\"id\":\"P35609\"},{\"label\":\"Amyloid-beta A4 precursor protein-binding family A member 1\",\"id\":\"Q02410\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Disks large homolog 1\",\"id\":\"Q12959\"},{\"label\":\"Disks large homolog 2\",\"id\":\"Q15700\"},{\"label\":\"Disks large homolog 3\",\"id\":\"Q92796\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 1\",\"id\":\"Q05586\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2A\",\"id\":\"Q12879\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2C\",\"id\":\"Q14957\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2D\",\"id\":\"O15399\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 3A\",\"id\":\"Q8TCU5\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 3B\",\"id\":\"O60391\"},{\"label\":\"Kinesin-like protein KIF17\",\"id\":\"Q9P2E2\"},{\"label\":\"Leucine-rich repeat-containing protein 7\",\"id\":\"Q96NW7\"},{\"label\":\"Neurobeachin\",\"id\":\"Q8NFP9\"},{\"label\":\"Neurofilament light polypeptide\",\"id\":\"P07196\"},{\"label\":\"Peripheral plasma membrane protein CASK\",\"id\":\"O14936\"},{\"label\":\"Protein lin-7 homolog A\",\"id\":\"O14910\"},{\"label\":\"Protein lin-7 homolog B\",\"id\":\"Q9HAP6\"},{\"label\":\"Protein lin-7 homolog C\",\"id\":\"Q9NUP9\"}]", "uniprot_id": "[\"O14910\",\"O14936\",\"O15399\",\"O60391\",\"P07196\",\"P35609\",\"P78352\",\"Q02410\",\"Q05586\",\"Q12879\",\"Q12959\",\"Q13224\",\"Q13554\",\"Q13555\",\"Q13557\",\"Q14957\",\"Q15700\",\"Q8NFP9\",\"Q8TCU5\",\"Q92796\",\"Q96NW7\",\"Q9HAP6\",\"Q9NUP9\",\"Q9P2E2\",\"Q9UQM7\"]", "gene_symbol": 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regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome 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type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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"[\"ADRM1\",\"AXIN\",\"AXIN1\",\"AXIN2\",\"C7orf76\",\"DSS1\",\"GP110\",\"HC2\",\"HC3\",\"HC8\",\"HC9\",\"HSPC\",\"KIAA0107\",\"LMPX\",\"LMPY\",\"MB1\",\"MIP224\",\"MOV34L\",\"MSS1\",\"NU\",\"PARP5A\",\"PARP5B\",\"PARPL\",\"PFAAP4\",\"POH1\",\"PROS26\",\"PROS27\",\"PROS30\",\"PSC2\",\"PSC3\",\"PSC5\",\"PSC8\",\"PSC9\",\"PSMA1\",\"PSMA2\",\"PSMA3\",\"PSMA4\",\"PSMA5\",\"PSMA6\",\"PSMA7\",\"PSMB1\",\"PSMB2\",\"PSMB3\",\"PSMB4\",\"PSMB5\",\"PSMB6\",\"PSMB7\",\"PSMC1\",\"PSMC2\",\"PSMC3\",\"PSMC4\",\"PSMC5\",\"PSMC6\",\"PSMD1\",\"PSMD11\",\"PSMD12\",\"PSMD13\",\"PSMD14\",\"PSMD2\",\"PSMD3\",\"PSMD6\",\"PSMD7\",\"PSMD8\",\"RNF146\",\"RPS27A\",\"SEM1\",\"SHFDG1\",\"SHFM1\",\"SMURF2\",\"SUG1\",\"SUG2\",\"TANK2\",\"TBP1\",\"TBP7\",\"TIN1\",\"TINF1\",\"TNKL\",\"TNKS\",\"TNKS1\",\"TNKS2\",\"TRAP2\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"X\",\"Y\",\"Z\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RHOB GTPase cycle", "protein_name": "[{\"label\":\"A-kinase anchor protein 13\",\"id\":\"Q12802\"},{\"label\":\"Actin, alpha cardiac muscle 1\",\"id\":\"P68032\"},{\"label\":\"Active breakpoint cluster region-related protein\",\"id\":\"Q12979\"},{\"label\":\"Anillin\",\"id\":\"Q9NQW6\"},{\"label\":\"Ankyrin repeat domain-containing protein SOWAHC\",\"id\":\"Q53LP3\"},{\"label\":\"Breakpoint cluster region protein\",\"id\":\"P11274\"},{\"label\":\"Caveolae-associated protein 1\",\"id\":\"Q6NZI2\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Cell surface glycoprotein MUC18\",\"id\":\"P43121\"},{\"label\":\"Citron Rho-interacting kinase\",\"id\":\"O14578\"},{\"label\":\"DEP domain-containing protein 1B\",\"id\":\"Q8WUY9\"},{\"label\":\"Disheveled-associated activator of morphogenesis 1\",\"id\":\"Q9Y4D1\"},{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Flotillin-1\",\"id\":\"O75955\"},{\"label\":\"Flotillin-2\",\"id\":\"Q14254\"},{\"label\":\"Guanine nucleotide exchange factor DBS\",\"id\":\"O15068\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Junction plakoglobin\",\"id\":\"P14923\"},{\"label\":\"Neuroepithelial cell-transforming gene 1 protein\",\"id\":\"Q7Z628\"},{\"label\":\"Oligophrenin-1\",\"id\":\"O60890\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Protein ECT2\",\"id\":\"Q9H8V3\"},{\"label\":\"Protein diaphanous homolog 1\",\"id\":\"O60610\"},{\"label\":\"Protein diaphanous homolog 3\",\"id\":\"Q9NSV4\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Protocadherin-7\",\"id\":\"O60245\"},{\"label\":\"Rac GTPase-activating protein 1\",\"id\":\"Q9H0H5\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP3\",\"id\":\"Q86VI3\"},{\"label\":\"Rho GDP-dissociation inhibitor 3\",\"id\":\"Q99819\"},{\"label\":\"Rho GTPase-activating protein 1\",\"id\":\"Q07960\"},{\"label\":\"Rho GTPase-activating protein 21\",\"id\":\"Q5T5U3\"},{\"label\":\"Rho GTPase-activating protein 26\",\"id\":\"Q9UNA1\"},{\"label\":\"Rho GTPase-activating protein 32\",\"id\":\"A7KAX9\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho GTPase-activating protein 39\",\"id\":\"Q9C0H5\"},{\"label\":\"Rho GTPase-activating protein 5\",\"id\":\"Q13017\"},{\"label\":\"Rho GTPase-activating protein 7\",\"id\":\"Q96QB1\"},{\"label\":\"Rho guanine nucleotide exchange factor 10-like protein\",\"id\":\"Q9HCE6\"},{\"label\":\"Rho guanine nucleotide exchange factor 10\",\"id\":\"O15013\"},{\"label\":\"Rho guanine nucleotide exchange factor 11\",\"id\":\"O15085\"},{\"label\":\"Rho guanine nucleotide exchange factor 12\",\"id\":\"Q9NZN5\"},{\"label\":\"Rho guanine nucleotide exchange factor 17\",\"id\":\"Q96PE2\"},{\"label\":\"Rho guanine nucleotide exchange factor 1\",\"id\":\"Q92888\"},{\"label\":\"Rho guanine nucleotide exchange factor 25\",\"id\":\"Q86VW2\"},{\"label\":\"Rho guanine nucleotide exchange factor 28\",\"id\":\"Q8N1W1\"},{\"label\":\"Rho guanine nucleotide exchange factor 2\",\"id\":\"Q92974\"},{\"label\":\"Rho guanine nucleotide exchange factor 3\",\"id\":\"Q9NR81\"},{\"label\":\"Rho guanine nucleotide exchange factor 5\",\"id\":\"Q12774\"},{\"label\":\"Rho-associated protein kinase 1\",\"id\":\"Q13464\"},{\"label\":\"Rho-associated protein kinase 2\",\"id\":\"O75116\"},{\"label\":\"Rho-related GTP-binding protein RhoB\",\"id\":\"P62745\"},{\"label\":\"Rhophilin-2\",\"id\":\"Q8IUC4\"},{\"label\":\"Rhotekin\",\"id\":\"Q9BST9\"},{\"label\":\"STE20-like serine/threonine-protein kinase\",\"id\":\"Q9H2G2\"},{\"label\":\"Serine/threonine-protein kinase 10\",\"id\":\"O94804\"},{\"label\":\"Serine/threonine-protein kinase N1\",\"id\":\"Q16512\"},{\"label\":\"Serine/threonine-protein kinase 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mono-ADP-ribosyltransferase PARP10\",\"id\":\"Q53GL7\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP14\",\"id\":\"Q460N5\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP16\",\"id\":\"Q8N5Y8\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP4\",\"id\":\"Q9UKK3\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP6\",\"id\":\"Q2NL67\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP8\",\"id\":\"Q8N3A8\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP9\",\"id\":\"Q8IXQ6\"},{\"label\":\"Renalase\",\"id\":\"Q5VYX0\"},{\"label\":\"Sodium-coupled monocarboxylate transporter 1\",\"id\":\"Q8N695\"},{\"label\":\"Solute carrier family 22 member 13\",\"id\":\"Q9Y226\"}]", "uniprot_id": "[\"P35354\",\"P40261\",\"P43490\",\"Q16647\",\"Q2NL67\",\"Q460N5\",\"Q53GL7\",\"Q5VYX0\",\"Q6XQN6\",\"Q8IW45\",\"Q8IXQ6\",\"Q8N3A8\",\"Q8N5Y8\",\"Q8N695\",\"Q8NCW5\",\"Q9BQG2\",\"Q9UKK3\",\"Q9UNU6\",\"Q9Y226\"]", "gene_symbol": 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inner hair cells of the cochlea", "protein_name": "[{\"label\":\"Band 4.1-like protein 1\",\"id\":\"Q9H4G0\"},{\"label\":\"Band 4.1-like protein 3\",\"id\":\"Q9Y2J2\"},{\"label\":\"Cadherin-23\",\"id\":\"Q9H251\"},{\"label\":\"Calcium and integrin-binding family member 2\",\"id\":\"O75838\"},{\"label\":\"Calcium-activated potassium channel subunit alpha-1\",\"id\":\"Q12791\"},{\"label\":\"Calcium-activated potassium channel subunit beta-1\",\"id\":\"Q16558\"},{\"label\":\"Calcium-binding protein 1\",\"id\":\"Q9NZU7\"},{\"label\":\"Calcium-binding protein 2\",\"id\":\"Q9NPB3\"},{\"label\":\"Chloride intracellular channel protein 5\",\"id\":\"Q9NZA1\"},{\"label\":\"DnaJ homolog subfamily C member 5\",\"id\":\"Q9H3Z4\"},{\"label\":\"Epidermal growth factor receptor kinase substrate 8-like protein 2\",\"id\":\"Q9H6S3\"},{\"label\":\"Epidermal growth factor receptor kinase substrate 8\",\"id\":\"Q12929\"},{\"label\":\"Espin-like 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repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Heme oxygenase 1\",\"id\":\"P09601\"},{\"label\":\"Hemoglobin subunit alpha\",\"id\":\"P69905\"},{\"label\":\"Hemoglobin subunit beta\",\"id\":\"P68871\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone-arginine methyltransferase CARM1\",\"id\":\"Q86X55\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 1\",\"id\":\"Q15648\"},{\"label\":\"Membrane-associated progesterone receptor component 2\",\"id\":\"O15173\"},{\"label\":\"Myocyte-specific enhancer factor 2C\",\"id\":\"Q06413\"},{\"label\":\"Myocyte-specific enhancer factor 2D\",\"id\":\"Q14814\"},{\"label\":\"NAD-dependent protein deacetylase sirtuin-1\",\"id\":\"Q96EB6\"},{\"label\":\"Neuronal PAS domain-containing protein 2\",\"id\":\"Q99743\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"},{\"label\":\"Nuclear receptor ROR-alpha\",\"id\":\"P35398\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Nuclear receptor coactivator 6\",\"id\":\"Q14686\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor subfamily 1 group D member 1\",\"id\":\"P20393\"},{\"label\":\"Nuclear receptor-interacting protein 1\",\"id\":\"P48552\"},{\"label\":\"Peroxisome proliferator-activated receptor alpha\",\"id\":\"Q07869\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha\",\"id\":\"Q9UBK2\"},{\"label\":\"Proton-coupled folate transporter\",\"id\":\"Q96NT5\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Retinoic acid-induced protein 1\",\"id\":\"Q7Z5J4\"},{\"label\":\"SWI/SNF-related 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"gtc_id": "[\"\"]" }, { "pathway_label": "Sema4D mediated inhibition of cell attachment and migration", "protein_name": "[{\"label\":\"Hepatocyte growth factor receptor\",\"id\":\"P08581\"},{\"label\":\"Plexin-B1\",\"id\":\"O43157\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Ras-related protein R-Ras\",\"id\":\"P10301\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho-related GTP-binding protein Rho6\",\"id\":\"Q92730\"},{\"label\":\"Semaphorin-4D\",\"id\":\"Q92854\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"}]", "uniprot_id": "[\"O43157\",\"P08581\",\"P10301\",\"P61586\",\"P63000\",\"Q92730\",\"Q92854\",\"Q9NRY4\"]", "gene_symbol": "[\"ARH12\",\"ARHA\",\"ARHGAP35\",\"C9orf164\",\"CD100\",\"GRF1\",\"GRLF1\",\"KIAA0407\",\"KIAA1722\",\"MET\",\"P190A\",\"PLXN5\",\"PLXNB1\",\"RAC1\",\"RHO12\",\"RHO6\",\"RHOA\",\"RND1\",\"RRAS\",\"SEMA4D\",\"SEMAJ\",\"SEP\",\"TC25\",\"p190ARHOGAP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-23 signaling", "protein_name": "[{\"label\":\"Interleukin-12 receptor subunit beta-1\",\"id\":\"P42701\"},{\"label\":\"Interleukin-12 subunit beta\",\"id\":\"P29460\"},{\"label\":\"Interleukin-23 receptor\",\"id\":\"Q5VWK5\"},{\"label\":\"Interleukin-23 subunit alpha\",\"id\":\"Q9NPF7\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Protein disulfide-isomerase\",\"id\":\"P07237\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 4\",\"id\":\"Q14765\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"}]", "uniprot_id": "[\"O60674\",\"P07237\",\"P29460\",\"P29597\",\"P40763\",\"P42701\",\"Q14765\",\"Q5VWK5\",\"Q9NPF7\"]", "gene_symbol": 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homolog\",\"id\":\"Q08AM6\"},{\"label\":\"Putative tyrosine-protein phosphatase TPTE\",\"id\":\"P56180\"}]", "uniprot_id": "[\"O00443\",\"O75747\",\"P42356\",\"P56180\",\"P61204\",\"P84077\",\"Q01968\",\"Q08AM6\",\"Q6XPS3\",\"Q8NEB9\",\"Q8TCG2\",\"Q92562\",\"Q99570\",\"Q9BTU6\",\"Q9NRR6\",\"Q9NTJ5\",\"Q9UBF8\",\"Q9Y2I7\"]", "gene_symbol": "[\"ARF1\",\"ARF3\",\"FIG4\",\"INPP5E\",\"KIAA0274\",\"KIAA0851\",\"KIAA0981\",\"OCRL\",\"OCRL1\",\"PI4K2A\",\"PI4K2B\",\"PI4KA\",\"PI4KB\",\"PIK3C2A\",\"PIK3C2G\",\"PIK3C3\",\"PIK3R4\",\"PIK4\",\"PIK4CA\",\"PIK4CB\",\"PIKFYVE\",\"PIP5K3\",\"SAC1\",\"SAC3\",\"SACM1L\",\"TAX1BP2\",\"TPIP\",\"TPTE\",\"TPTE2\",\"TRX\",\"VAC14\",\"VPS15\",\"VPS34\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "tRNA modification in the nucleus and cytosol", "protein_name": "[{\"label\":\"Alkylated DNA repair protein alkB homolog 8\",\"id\":\"Q96BT7\"},{\"label\":\"Bifunctional glutamate/proline--tRNA ligase\",\"id\":\"P07814\"},{\"label\":\"Cytoplasmic tRNA 2-thiolation 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WDR4\",\"id\":\"P57081\"},{\"label\":\"tRNA (guanine-N(7)-)-methyltransferase\",\"id\":\"Q9UBP6\"},{\"label\":\"tRNA N6-adenosine threonylcarbamoyltransferase\",\"id\":\"Q9NPF4\"},{\"label\":\"tRNA dimethylallyltransferase\",\"id\":\"Q9H3H1\"},{\"label\":\"tRNA methyltransferase 10 homolog A\",\"id\":\"Q8TBZ6\"},{\"label\":\"tRNA pseudouridine(38/39) synthase\",\"id\":\"Q9BZE2\"},{\"label\":\"tRNA-dihydrouridine(20) synthase [NAD(P)+]-like\",\"id\":\"Q9NX74\"},{\"label\":\"tRNA-specific adenosine deaminase 1\",\"id\":\"Q9BUB4\"},{\"label\":\"tRNA-specific adenosine deaminase 2\",\"id\":\"Q7Z6V5\"},{\"label\":\"tRNA\",\"id\":\"m(4)X modification enzyme TRM13 homolog:Q9NUP7\"}]", "uniprot_id": 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protein 6 homolog\",\"id\":\"Q99741\"},{\"label\":\"DNA helicase MCM8\",\"id\":\"Q9UJA3\"},{\"label\":\"Origin recognition complex subunit 1\",\"id\":\"Q13415\"},{\"label\":\"Origin recognition complex subunit 2\",\"id\":\"Q13416\"},{\"label\":\"Origin recognition complex subunit 3\",\"id\":\"Q9UBD5\"},{\"label\":\"Origin recognition complex subunit 4\",\"id\":\"O43929\"},{\"label\":\"Origin recognition complex subunit 5\",\"id\":\"O43913\"},{\"label\":\"Origin recognition complex subunit 6\",\"id\":\"Q9Y5N6\"}]", "uniprot_id": "[\"O43913\",\"O43929\",\"Q13415\",\"Q13416\",\"Q99741\",\"Q9UBD5\",\"Q9UJA3\",\"Q9Y5N6\"]", "gene_symbol": "[\"C20orf154\",\"CDC18L\",\"CDC6\",\"LATHEO\",\"MCM8\",\"ORC1\",\"ORC1L\",\"ORC2\",\"ORC2L\",\"ORC3\",\"ORC3L\",\"ORC4\",\"ORC4L\",\"ORC5\",\"ORC5L\",\"ORC6\",\"ORC6L\",\"PARC1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G alpha (i) signalling events", "protein_name": "[{\"label\":\"12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor\",\"id\":\"O00270\"},{\"label\":\"2-oxoglutarate receptor 1\",\"id\":\"Q96P68\"},{\"label\":\"5-hydroxytryptamine receptor 1B\",\"id\":\"P28222\"},{\"label\":\"5-hydroxytryptamine receptor 1D\",\"id\":\"P28221\"},{\"label\":\"5-hydroxytryptamine receptor 1E\",\"id\":\"P28566\"},{\"label\":\"5-hydroxytryptamine receptor 1F\",\"id\":\"P30939\"},{\"label\":\"5-hydroxytryptamine receptor 5A\",\"id\":\"P47898\"},{\"label\":\"Adenosine receptor A1\",\"id\":\"P30542\"},{\"label\":\"Adenosine receptor A3\",\"id\":\"P0DMS8\"},{\"label\":\"Adenylate cyclase type 1\",\"id\":\"Q08828\"},{\"label\":\"Adenylate cyclase type 2\",\"id\":\"Q08462\"},{\"label\":\"Adenylate cyclase type 3\",\"id\":\"O60266\"},{\"label\":\"Adenylate cyclase type 4\",\"id\":\"Q8NFM4\"},{\"label\":\"Adenylate cyclase type 5\",\"id\":\"O95622\"},{\"label\":\"Adenylate cyclase type 6\",\"id\":\"O43306\"},{\"label\":\"Adenylate cyclase type 7\",\"id\":\"P51828\"},{\"label\":\"Adenylate cyclase type 8\",\"id\":\"P40145\"},{\"label\":\"Adenylate cyclase type 9\",\"id\":\"O60503\"},{\"label\":\"Alpha-2A adrenergic receptor\",\"id\":\"P08913\"},{\"label\":\"Alpha-2B adrenergic receptor\",\"id\":\"P18089\"},{\"label\":\"Alpha-2C adrenergic receptor\",\"id\":\"P18825\"},{\"label\":\"Amyloid-beta precursor protein\",\"id\":\"P05067\"},{\"label\":\"Angiotensinogen\",\"id\":\"P01019\"},{\"label\":\"Annexin A1\",\"id\":\"P04083\"},{\"label\":\"Apelin receptor\",\"id\":\"P35414\"},{\"label\":\"Apelin\",\"id\":\"Q9ULZ1\"},{\"label\":\"Atypical chemokine receptor 3\",\"id\":\"P25106\"},{\"label\":\"B1 bradykinin receptor\",\"id\":\"P46663\"},{\"label\":\"B2 bradykinin receptor\",\"id\":\"P30411\"},{\"label\":\"C-C chemokine receptor type 10\",\"id\":\"P46092\"},{\"label\":\"C-C chemokine receptor type 1\",\"id\":\"P32246\"},{\"label\":\"C-C chemokine receptor type 2\",\"id\":\"P41597\"},{\"label\":\"C-C chemokine receptor type 3\",\"id\":\"P51677\"},{\"label\":\"C-C chemokine receptor type 4\",\"id\":\"P51679\"},{\"label\":\"C-C chemokine receptor type 5\",\"id\":\"P51681\"},{\"label\":\"C-C chemokine receptor type 6\",\"id\":\"P51684\"},{\"label\":\"C-C chemokine receptor type 7\",\"id\":\"P32248\"},{\"label\":\"C-C chemokine receptor type 8\",\"id\":\"P51685\"},{\"label\":\"C-C chemokine receptor type 9\",\"id\":\"P51686\"},{\"label\":\"C-C motif chemokine 13\",\"id\":\"Q99616\"},{\"label\":\"C-C motif chemokine 16\",\"id\":\"O15467\"},{\"label\":\"C-C motif chemokine 19\",\"id\":\"Q99731\"},{\"label\":\"C-C motif chemokine 1\",\"id\":\"P22362\"},{\"label\":\"C-C motif chemokine 20\",\"id\":\"P78556\"},{\"label\":\"C-C motif chemokine 21\",\"id\":\"O00585\"},{\"label\":\"C-C motif chemokine 25\",\"id\":\"O15444\"},{\"label\":\"C-C motif chemokine 27\",\"id\":\"Q9Y4X3\"},{\"label\":\"C-C motif chemokine 28\",\"id\":\"Q9NRJ3\"},{\"label\":\"C-C motif chemokine 4-like\",\"id\":\"Q8NHW4\"},{\"label\":\"C-C motif chemokine 4\",\"id\":\"P13236\"},{\"label\":\"C-C motif chemokine 5\",\"id\":\"P13501\"},{\"label\":\"C-X-C chemokine receptor type 1\",\"id\":\"P25024\"},{\"label\":\"C-X-C chemokine receptor type 2\",\"id\":\"P25025\"},{\"label\":\"C-X-C chemokine receptor type 3\",\"id\":\"P49682\"},{\"label\":\"C-X-C chemokine receptor type 4\",\"id\":\"P61073\"},{\"label\":\"C-X-C chemokine receptor type 5\",\"id\":\"P32302\"},{\"label\":\"C-X-C chemokine receptor type 6\",\"id\":\"O00574\"},{\"label\":\"C-X-C motif chemokine 10\",\"id\":\"P02778\"},{\"label\":\"C-X-C motif chemokine 11\",\"id\":\"O14625\"},{\"label\":\"C-X-C motif chemokine 13\",\"id\":\"O43927\"},{\"label\":\"C-X-C motif chemokine 16\",\"id\":\"Q9H2A7\"},{\"label\":\"C-X-C motif chemokine 2\",\"id\":\"P19875\"},{\"label\":\"C-X-C motif chemokine 3\",\"id\":\"P19876\"},{\"label\":\"C-X-C motif chemokine 5\",\"id\":\"P42830\"},{\"label\":\"C-X-C motif chemokine 6\",\"id\":\"P80162\"},{\"label\":\"C-X-C motif chemokine 9\",\"id\":\"Q07325\"},{\"label\":\"C3a anaphylatoxin chemotactic 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phosphoribosyltransferase\",\"id\":\"P07741\"}]", "uniprot_id": "[\"P07741\"]", "gene_symbol": "[\"APRT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of aspirin-triggered D-series resolvins", "protein_name": "[{\"label\":\"Leukotriene A-4 hydrolase\",\"id\":\"P09960\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"}]", "uniprot_id": "[\"P09917\",\"P09960\"]", "gene_symbol": "[\"ALOX5\",\"LOG5\",\"LTA4\",\"LTA4H\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of commissural axon pathfinding by SLIT and ROBO", "protein_name": "[{\"label\":\"Netrin receptor DCC\",\"id\":\"P43146\"},{\"label\":\"Netrin-1\",\"id\":\"O95631\"},{\"label\":\"Protein kinase C-binding protein NELL2\",\"id\":\"Q99435\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Roundabout homolog 1\",\"id\":\"Q9Y6N7\"},{\"label\":\"Roundabout homolog 2\",\"id\":\"Q9HCK4\"},{\"label\":\"Slit homolog 1 protein\",\"id\":\"O75093\"},{\"label\":\"Slit homolog 2 protein\",\"id\":\"O94813\"},{\"label\":\"Slit homolog 3 protein\",\"id\":\"O75094\"}]", "uniprot_id": "[\"O75093\",\"O75094\",\"O94813\",\"O95631\",\"P12931\",\"P43146\",\"Q99435\",\"Q9HCK4\",\"Q9Y6N7\"]", "gene_symbol": "[\"DCC\",\"DUTT1\",\"IGDCC1\",\"KIAA0813\",\"KIAA0814\",\"KIAA1568\",\"MEGF4\",\"MEGF5\",\"NELL2\",\"NRP2\",\"NTN1\",\"NTN1L\",\"ROBO1\",\"ROBO2\",\"SLIL1\",\"SLIL2\",\"SLIL3\",\"SLIT1\",\"SLIT2\",\"SLIT3\",\"SRC\",\"SRC1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "protein_name": "[{\"label\":\"Coagulation factor IX\",\"id\":\"P00740\"},{\"label\":\"Coagulation factor VII\",\"id\":\"P08709\"},{\"label\":\"Coagulation factor X\",\"id\":\"P00742\"},{\"label\":\"Growth arrest-specific protein 6\",\"id\":\"Q14393\"},{\"label\":\"Osteocalcin\",\"id\":\"P02818\"},{\"label\":\"Prothrombin\",\"id\":\"P00734\"},{\"label\":\"Vitamin K-dependent protein C\",\"id\":\"P04070\"},{\"label\":\"Vitamin K-dependent protein S\",\"id\":\"P07225\"},{\"label\":\"Vitamin K-dependent protein Z\",\"id\":\"P22891\"}]", "uniprot_id": "[\"P00734\",\"P00740\",\"P00742\",\"P02818\",\"P04070\",\"P07225\",\"P08709\",\"P22891\",\"Q14393\"]", "gene_symbol": "[\"AXLLG\",\"BGLAP\",\"F10\",\"F2\",\"F7\",\"F9\",\"GAS6\",\"PROC\",\"PROS\",\"PROS1\",\"PROZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NR1D1 (REV-ERBA) represses gene expression", "protein_name": "[{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor subfamily 1 group D member 1\",\"id\":\"P20393\"}]", "uniprot_id": "[\"O15379\",\"O75376\",\"P20393\"]", "gene_symbol": "[\"EAR1\",\"HDAC3\",\"HREV\",\"KIAA1047\",\"NCOR1\",\"NR1D1\",\"THRAL\"]", 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antigen\",\"id\":\"Q9NPF0\"},{\"label\":\"Transcobalamin-2\",\"id\":\"P20062\"}]", "uniprot_id": "[\"P20062\",\"Q9NPF0\"]", "gene_symbol": "[\"8D6A\",\"CD320\",\"TC2\",\"TCN2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"5'-3' exoribonuclease 1\",\"id\":\"Q8IZH2\"},{\"label\":\"Exosome complex component CSL4\",\"id\":\"Q9Y3B2\"},{\"label\":\"Exosome complex component MTR3\",\"id\":\"Q5RKV6\"},{\"label\":\"Exosome complex component RRP40\",\"id\":\"Q9NQT5\"},{\"label\":\"Exosome complex component RRP41\",\"id\":\"Q9NPD3\"},{\"label\":\"Exosome complex component RRP42\",\"id\":\"Q15024\"},{\"label\":\"Exosome complex component RRP43\",\"id\":\"Q96B26\"},{\"label\":\"Exosome complex component RRP45\",\"id\":\"Q06265\"},{\"label\":\"Exosome complex component RRP46\",\"id\":\"Q9NQT4\"},{\"label\":\"Exosome complex component 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"[\"\"]" }, { "pathway_label": "N-Glycan antennae elongation", "protein_name": "[{\"label\":\"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A\",\"id\":\"Q9UM21\"},{\"label\":\"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B\",\"id\":\"Q9UQ53\"},{\"label\":\"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C\",\"id\":\"Q9UBM8\"},{\"label\":\"Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A\",\"id\":\"Q09328\"},{\"label\":\"Alpha-2,8-sialyltransferase 8B\",\"id\":\"Q92186\"},{\"label\":\"Alpha-2,8-sialyltransferase 8F\",\"id\":\"P61647\"},{\"label\":\"Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3\",\"id\":\"O43173\"},{\"label\":\"Beta-1,4-galactosyltransferase 1\",\"id\":\"P15291\"},{\"label\":\"Beta-1,4-galactosyltransferase 2\",\"id\":\"O60909\"},{\"label\":\"Beta-1,4-galactosyltransferase 3\",\"id\":\"O60512\"},{\"label\":\"Beta-1,4-galactosyltransferase 4\",\"id\":\"O60513\"},{\"label\":\"Beta-1,4-galactosyltransferase 5\",\"id\":\"O43286\"},{\"label\":\"Beta-1,4-galactosyltransferase 6\",\"id\":\"Q9UBX8\"},{\"label\":\"Beta-galactoside alpha-2,6-sialyltransferase 1\",\"id\":\"P15907\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4\",\"id\":\"Q11206\"}]", "uniprot_id": "[\"O43173\",\"O43286\",\"O60512\",\"O60513\",\"O60909\",\"P15291\",\"P15907\",\"P61647\",\"Q09328\",\"Q11206\",\"Q92186\",\"Q9UBM8\",\"Q9UBX8\",\"Q9UM21\",\"Q9UQ53\"]", "gene_symbol": "[\"B4GALT1\",\"B4GALT2\",\"B4GALT3\",\"B4GALT4\",\"B4GALT5\",\"B4GALT6\",\"CGS23\",\"GGNT5\",\"GGTB2\",\"MGAT4A\",\"MGAT4B\",\"MGAT4C\",\"MGAT5\",\"NANTA3\",\"SIAT1\",\"SIAT4C\",\"SIAT8B\",\"SIAT8C\",\"SIAT8F\",\"ST3GAL4\",\"ST6GAL1\",\"ST8SIA2\",\"ST8SIA3\",\"ST8SIA6\",\"STX\",\"STZ\"]", "gtc_id": "[\"G81533KY\"]" }, { "pathway_label": "Association of TriC/CCT with target proteins during biosynthesis", "protein_name": "[{\"label\":\"5'-3' exoribonuclease 2\",\"id\":\"Q9H0D6\"},{\"label\":\"AP-3 complex subunit mu-1\",\"id\":\"Q9Y2T2\"},{\"label\":\"Brefeldin A-inhibited guanine nucleotide-exchange protein 2\",\"id\":\"Q9Y6D5\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"DDB1- and CUL4-associated factor 7\",\"id\":\"P61962\"},{\"label\":\"F-box only protein 4\",\"id\":\"Q9UKT5\"},{\"label\":\"F-box only protein 6\",\"id\":\"Q9NRD1\"},{\"label\":\"F-box/LRR-repeat protein 3\",\"id\":\"Q9UKT7\"},{\"label\":\"F-box/LRR-repeat protein 5\",\"id\":\"Q9UKA1\"},{\"label\":\"F-box/WD repeat-containing protein 10\",\"id\":\"Q5XX13\"},{\"label\":\"F-box/WD repeat-containing protein 2\",\"id\":\"Q9UKT8\"},{\"label\":\"F-box/WD repeat-containing protein 4\",\"id\":\"P57775\"},{\"label\":\"F-box/WD repeat-containing protein 5\",\"id\":\"Q969U6\"},{\"label\":\"F-box/WD repeat-containing protein 7\",\"id\":\"Q969H0\"},{\"label\":\"F-box/WD repeat-containing protein 9\",\"id\":\"Q5XUX1\"},{\"label\":\"G1/S-specific cyclin-E1\",\"id\":\"P24864\"},{\"label\":\"G1/S-specific cyclin-E2\",\"id\":\"O96020\"},{\"label\":\"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific\",\"id\":\"O14556\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Kinesin-like protein KIF13A\",\"id\":\"Q9H1H9\"},{\"label\":\"Lon protease homolog 2, peroxisomal\",\"id\":\"Q86WA8\"},{\"label\":\"Lysosomal acid glucosylceramidase\",\"id\":\"P04062\"},{\"label\":\"Nucleolar protein 56\",\"id\":\"O00567\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase FKBP9\",\"id\":\"O95302\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Sphingosine kinase 1\",\"id\":\"Q9NYA1\"},{\"label\":\"Superkiller complex protein 2\",\"id\":\"Q15477\"},{\"label\":\"T-complex protein 1 subunit alpha\",\"id\":\"P17987\"},{\"label\":\"T-complex protein 1 subunit beta\",\"id\":\"P78371\"},{\"label\":\"T-complex protein 1 subunit delta\",\"id\":\"P50991\"},{\"label\":\"T-complex protein 1 subunit epsilon\",\"id\":\"P48643\"},{\"label\":\"T-complex protein 1 subunit eta\",\"id\":\"Q99832\"},{\"label\":\"T-complex protein 1 subunit gamma\",\"id\":\"P49368\"},{\"label\":\"T-complex protein 1 subunit theta\",\"id\":\"P50990\"},{\"label\":\"T-complex protein 1 subunit zeta-2\",\"id\":\"Q92526\"},{\"label\":\"T-complex protein 1 subunit zeta\",\"id\":\"P40227\"},{\"label\":\"Telomerase Cajal body protein 1\",\"id\":\"Q9BUR4\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 11\",\"id\":\"P51784\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Translesion synthesis by POLI", "protein_name": "[{\"label\":\"DNA polymerase iota\",\"id\":\"Q9UNA4\"},{\"label\":\"DNA polymerase zeta catalytic subunit\",\"id\":\"O60673\"},{\"label\":\"DNA repair protein REV1\",\"id\":\"Q9UBZ9\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2B\",\"id\":\"Q9UI95\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Replication factor C subunit 1\",\"id\":\"P35251\"},{\"label\":\"Replication factor C subunit 2\",\"id\":\"P35250\"},{\"label\":\"Replication factor C subunit 3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O60673\",\"P0CG47\",\"P0CG48\",\"P12004\",\"P15927\",\"P27694\",\"P35244\",\"P35249\",\"P35250\",\"P35251\",\"P40937\",\"P40938\",\"P62979\",\"P62987\",\"Q9UBZ9\",\"Q9UI95\",\"Q9UNA4\"]", "gene_symbol": "[\"MAD2B\",\"MAD2L2\",\"PCNA\",\"POLI\",\"POLZ\",\"RAD30B\",\"REPA1\",\"REPA2\",\"REPA3\",\"REV1\",\"REV1L\",\"REV3\",\"REV3L\",\"REV7\",\"RFC1\",\"RFC140\",\"RFC2\",\"RFC3\",\"RFC4\",\"RFC5\",\"RPA1\",\"RPA14\",\"RPA2\",\"RPA3\",\"RPA32\",\"RPA34\",\"RPA70\",\"RPS27A\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of 12-eicosatetraenoic acid derivatives", "protein_name": "[{\"label\":\"Arachidonate 12-lipoxygenase, 12R-type\",\"id\":\"O75342\"},{\"label\":\"Glutathione peroxidase 1\",\"id\":\"P07203\"},{\"label\":\"Glutathione peroxidase 2\",\"id\":\"P18283\"},{\"label\":\"Hydroperoxide isomerase ALOXE3\",\"id\":\"Q9BYJ1\"},{\"label\":\"Phospholipid hydroperoxide glutathione peroxidase GPX4\",\"id\":\"P36969\"},{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX12\",\"id\":\"P18054\"},{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX15\",\"id\":\"P16050\"}]", "uniprot_id": "[\"O75342\",\"P07203\",\"P16050\",\"P18054\",\"P18283\",\"P36969\",\"Q9BYJ1\"]", "gene_symbol": "[\"12LO\",\"ALOX12\",\"ALOX12B\",\"ALOX15\",\"ALOXE3\",\"GPX1\",\"GPX2\",\"GPX4\",\"LOG12\",\"LOG15\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Glucagon-type ligand receptors", "protein_name": "[{\"label\":\"Gastric inhibitory polypeptide receptor\",\"id\":\"P48546\"},{\"label\":\"Gastric inhibitory polypeptide\",\"id\":\"P09681\"},{\"label\":\"Glucagon receptor\",\"id\":\"P47871\"},{\"label\":\"Glucagon-like peptide 1 receptor\",\"id\":\"P43220\"},{\"label\":\"Glucagon-like peptide 2 receptor\",\"id\":\"O95838\"},{\"label\":\"Growth hormone-releasing hormone receptor\",\"id\":\"Q02643\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas\",\"id\":\"Q5JWF2\"},{\"label\":\"Guanine nucleotide-binding protein G(s) subunit alpha isoforms short\",\"id\":\"P63092\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Pituitary adenylate cyclase-activating polypeptide type I receptor\",\"id\":\"P41586\"},{\"label\":\"Pituitary adenylate cyclase-activating polypeptide\",\"id\":\"P18509\"},{\"label\":\"Pro-glucagon\",\"id\":\"P01275\"},{\"label\":\"Secretin receptor\",\"id\":\"P47872\"},{\"label\":\"Secretin\",\"id\":\"P09683\"},{\"label\":\"Somatoliberin\",\"id\":\"P01286\"},{\"label\":\"VIP peptides\",\"id\":\"P01282\"},{\"label\":\"Vasoactive intestinal polypeptide receptor 1\",\"id\":\"P32241\"},{\"label\":\"Vasoactive intestinal polypeptide receptor 2\",\"id\":\"P41587\"}]", "uniprot_id": 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mitochondrial\",\"id\":\"P05091\"},{\"label\":\"Annexin A1\",\"id\":\"P04083\"},{\"label\":\"Annexin A2\",\"id\":\"P07355\"},{\"label\":\"Annexin A6\",\"id\":\"P08133\"},{\"label\":\"Caldesmon\",\"id\":\"Q05682\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Caveolin-3\",\"id\":\"P56539\"},{\"label\":\"Dysferlin\",\"id\":\"O75923\"},{\"label\":\"Guanylate cyclase soluble subunit alpha-1\",\"id\":\"Q02108\"},{\"label\":\"Guanylate cyclase soluble subunit alpha-2\",\"id\":\"P33402\"},{\"label\":\"Guanylate cyclase soluble subunit beta-1\",\"id\":\"Q02153\"},{\"label\":\"Guanylate cyclase soluble subunit beta-2\",\"id\":\"O75343\"},{\"label\":\"Integrin alpha-1\",\"id\":\"P56199\"},{\"label\":\"Integrin beta-5\",\"id\":\"P18084\"},{\"label\":\"Leiomodin-1\",\"id\":\"P29536\"},{\"label\":\"Myosin light chain 5\",\"id\":\"Q02045\"},{\"label\":\"Myosin light chain 6B\",\"id\":\"P14649\"},{\"label\":\"Myosin light chain kinase, smooth 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proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Anaphase-promoting complex subunit 10\",\"id\":\"Q9UM13\"},{\"label\":\"Anaphase-promoting complex subunit 11\",\"id\":\"Q9NYG5\"},{\"label\":\"Anaphase-promoting complex subunit 15\",\"id\":\"P60006\"},{\"label\":\"Anaphase-promoting complex subunit 16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 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"gtc_id": "[\"\"]" }, { "pathway_label": "NTRK2 activates RAC1", "protein_name": "[{\"label\":\"BDNF/NT-3 growth factors receptor\",\"id\":\"Q16620\"},{\"label\":\"Brain-derived neurotrophic factor\",\"id\":\"P23560\"},{\"label\":\"Dedicator of cytokinesis protein 3\",\"id\":\"Q8IZD9\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"}]", "uniprot_id": "[\"P23560\",\"P63000\",\"Q16620\",\"Q8IZD9\"]", "gene_symbol": "[\"BDNF\",\"DOCK3\",\"KIAA0299\",\"MOCA\",\"NTRK2\",\"RAC1\",\"TC25\",\"TRKB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Pyrimidine salvage", "protein_name": "[{\"label\":\"Cytidine deaminase\",\"id\":\"P32320\"},{\"label\":\"Deoxycytidine kinase\",\"id\":\"P27707\"},{\"label\":\"Pseudouridine-5'-phosphatase\",\"id\":\"Q08623\"},{\"label\":\"Thymidine kinase 2, mitochondrial\",\"id\":\"O00142\"},{\"label\":\"Thymidine kinase, cytosolic\",\"id\":\"P04183\"},{\"label\":\"Thymidine phosphorylase\",\"id\":\"P19971\"},{\"label\":\"Uridine phosphorylase 1\",\"id\":\"Q16831\"},{\"label\":\"Uridine phosphorylase 2\",\"id\":\"O95045\"},{\"label\":\"Uridine-cytidine kinase 1\",\"id\":\"Q9HA47\"},{\"label\":\"Uridine-cytidine kinase 2\",\"id\":\"Q9BZX2\"},{\"label\":\"Uridine-cytidine kinase-like 1\",\"id\":\"Q9NWZ5\"}]", "uniprot_id": "[\"O00142\",\"O95045\",\"P04183\",\"P19971\",\"P27707\",\"P32320\",\"Q08623\",\"Q16831\",\"Q9BZX2\",\"Q9HA47\",\"Q9NWZ5\"]", "gene_symbol": "[\"CDA\",\"CDD\",\"DCK\",\"DXF68S1E\",\"ECGF1\",\"FAM16AX\",\"GS1\",\"HDHD1\",\"HDHD1A\",\"PUDP\",\"TK1\",\"TK2\",\"TYMP\",\"UCK1\",\"UCK2\",\"UCKL1\",\"UMPK\",\"UP\",\"UPP1\",\"UPP2\",\"URK1\",\"URKL1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Protein hydroxylation", "protein_name": "[{\"label\":\"2-oxoglutarate and iron-dependent oxygenase JMJD4\",\"id\":\"Q9H9V9\"},{\"label\":\"Aspartyl/asparaginyl beta-hydroxylase\",\"id\":\"Q12797\"},{\"label\":\"Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6\",\"id\":\"Q6NYC1\"},{\"label\":\"Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7\",\"id\":\"P0C870\"},{\"label\":\"Bifunctional peptidase and arginyl-hydroxylase JMJD5\",\"id\":\"Q8N371\"},{\"label\":\"Coagulation factor IX\",\"id\":\"P00740\"},{\"label\":\"Developmentally-regulated GTP-binding protein 1\",\"id\":\"Q9Y295\"},{\"label\":\"Developmentally-regulated GTP-binding protein 2\",\"id\":\"P55039\"},{\"label\":\"Eukaryotic peptide chain release factor subunit 1\",\"id\":\"P62495\"},{\"label\":\"Large ribosomal subunit protein uL15\",\"id\":\"P46776\"},{\"label\":\"Large ribosomal subunit protein uL2\",\"id\":\"P62917\"},{\"label\":\"Prolyl 3-hydroxylase OGFOD1\",\"id\":\"Q8N543\"},{\"label\":\"RCC1 domain-containing protein 1\",\"id\":\"A6NED2\"},{\"label\":\"RWD domain-containing protein 1\",\"id\":\"Q9H446\"},{\"label\":\"Ribosomal oxygenase 1\",\"id\":\"Q9H6W3\"},{\"label\":\"Ribosomal oxygenase 2\",\"id\":\"Q8IUF8\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein uS12\",\"id\":\"P62266\"},{\"label\":\"Splicing factor U2AF 65 kDa subunit\",\"id\":\"P26368\"},{\"label\":\"Zinc finger CCCH domain-containing protein 15\",\"id\":\"Q8WU90\"}]", "uniprot_id": "[\"A6NED2\",\"P00740\",\"P0C870\",\"P26368\",\"P46776\",\"P55039\",\"P62266\",\"P62495\",\"P62753\",\"P62917\",\"Q12797\",\"Q6NYC1\",\"Q8IUF8\",\"Q8N371\",\"Q8N543\",\"Q8WU90\",\"Q9H446\",\"Q9H6W3\",\"Q9H9V9\",\"Q9Y295\"]", "gene_symbol": "[\"ASPH\",\"BAH\",\"C14orf169\",\"DFRP1\",\"DFRP2\",\"DRG1\",\"DRG2\",\"ERF1\",\"ETF1\",\"F9\",\"JMJD4\",\"JMJD5\",\"JMJD6\",\"JMJD7\",\"KDM8\",\"KIAA0585\",\"KIAA1612\",\"LEREPO4\",\"MAPJD\",\"MDIG\",\"MINA\",\"MINA53\",\"NEDD3\",\"NO52\",\"NO66\",\"OGFOD1\",\"PSR\",\"PTDSR\",\"RCCD1\",\"RF1\",\"RIOX1\",\"RIOX2\",\"RPL27A\",\"RPL8\",\"RPS23\",\"RPS6\",\"RWDD1\",\"SUP45L1\",\"TPA1\",\"U2AF2\",\"U2AF65\",\"ZC3H15\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)", "protein_name": "[{\"label\":\"Solute carrier family 12 member 6\",\"id\":\"Q9UHW9\"}]", "uniprot_id": "[\"Q9UHW9\"]", "gene_symbol": "[\"KCC3\",\"SLC12A6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regorafenib-resistant PDGFR mutants", "protein_name": "[{\"label\":\"Platelet-derived growth factor receptor alpha\",\"id\":\"P16234\"}]", "uniprot_id": "[\"P16234\"]", "gene_symbol": "[\"PDGFR2\",\"PDGFRA\",\"RHEPDGFRA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of NPAS4 gene transcription", "protein_name": "[{\"label\":\"Calsenilin\",\"id\":\"Q9Y2W7\"},{\"label\":\"Glucocorticoid receptor\",\"id\":\"P04150\"},{\"label\":\"RE1-silencing transcription factor\",\"id\":\"Q13127\"},{\"label\":\"Serum response factor\",\"id\":\"P11831\"}]", "uniprot_id": "[\"P04150\",\"P11831\",\"Q13127\",\"Q9Y2W7\"]", "gene_symbol": "[\"CSEN\",\"DREAM\",\"GRL\",\"KCHIP3\",\"KCNIP3\",\"NR3C1\",\"NRSF\",\"REST\",\"SRF\",\"XBR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "betaKlotho-mediated ligand binding", "protein_name": "[{\"label\":\"Beta-klotho\",\"id\":\"Q86Z14\"},{\"label\":\"Fibroblast growth factor 19\",\"id\":\"O95750\"},{\"label\":\"Fibroblast growth factor receptor 4\",\"id\":\"P22455\"}]", "uniprot_id": "[\"O95750\",\"P22455\",\"Q86Z14\"]", "gene_symbol": "[\"FGF19\",\"FGFR4\",\"JTK2\",\"KLB\",\"TKF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PERK regulates gene expression", "protein_name": "[{\"label\":\"Cyclic AMP-dependent transcription factor ATF-4\",\"id\":\"P18848\"},{\"label\":\"Endoplasmic reticulum chaperone BiP\",\"id\":\"P11021\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 1\",\"id\":\"P05198\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 2\",\"id\":\"P20042\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 3\",\"id\":\"P41091\"},{\"label\":\"Eukaryotic translation initiation factor 2-alpha kinase 3\",\"id\":\"Q9NZJ5\"}]", "uniprot_id": "[\"P05198\",\"P11021\",\"P18848\",\"P20042\",\"P41091\",\"Q9NZJ5\"]", "gene_symbol": "[\"ATF4\",\"CREB2\",\"EIF2A\",\"EIF2AK3\",\"EIF2B\",\"EIF2G\",\"EIF2S1\",\"EIF2S2\",\"EIF2S3\",\"GRP78\",\"HSPA5\",\"PEK\",\"PERK\",\"TXREB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective regulation of TLR7 by endogenous ligand", "protein_name": "[{\"label\":\"Toll-like receptor 7\",\"id\":\"Q9NYK1\"}]", "uniprot_id": "[\"Q9NYK1\"]", "gene_symbol": "[\"TLR7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)", "protein_name": "[{\"label\":\"Equilibrative nucleoside transporter 3\",\"id\":\"Q9BZD2\"}]", "uniprot_id": "[\"Q9BZD2\"]", "gene_symbol": "[\"ENT3\",\"SLC29A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of FZD by ubiquitination", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase RNF43\",\"id\":\"Q68DV7\"},{\"label\":\"E3 ubiquitin-protein ligase ZNRF3\",\"id\":\"Q9ULT6\"},{\"label\":\"Frizzled-4\",\"id\":\"Q9ULV1\"},{\"label\":\"Frizzled-5\",\"id\":\"Q13467\"},{\"label\":\"Frizzled-6\",\"id\":\"O60353\"},{\"label\":\"Frizzled-8\",\"id\":\"Q9H461\"},{\"label\":\"Leucine-rich repeat-containing G-protein coupled receptor 4\",\"id\":\"Q9BXB1\"},{\"label\":\"Leucine-rich repeat-containing G-protein coupled receptor 5\",\"id\":\"O75473\"},{\"label\":\"Leucine-rich repeat-containing G-protein coupled receptor 6\",\"id\":\"Q9HBX8\"},{\"label\":\"Low-density lipoprotein receptor-related protein 5\",\"id\":\"O75197\"},{\"label\":\"Low-density lipoprotein receptor-related protein 6\",\"id\":\"O75581\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein 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LAMTOR2\",\"id\":\"Q9Y2Q5\"},{\"label\":\"Ragulator complex protein LAMTOR3\",\"id\":\"Q9UHA4\"},{\"label\":\"Ragulator complex protein LAMTOR4\",\"id\":\"Q0VGL1\"},{\"label\":\"Ragulator complex protein LAMTOR5\",\"id\":\"O43504\"},{\"label\":\"Ras-related GTP-binding protein A\",\"id\":\"Q7L523\"},{\"label\":\"Ras-related GTP-binding protein B\",\"id\":\"Q5VZM2\"},{\"label\":\"Ras-related GTP-binding protein C\",\"id\":\"Q9HB90\"},{\"label\":\"Ras-related GTP-binding protein D\",\"id\":\"Q9NQL2\"},{\"label\":\"Regulatory-associated protein of mTOR\",\"id\":\"Q8N122\"},{\"label\":\"STE20-related kinase adapter protein alpha\",\"id\":\"Q7RTN6\"},{\"label\":\"STE20-related kinase adapter protein beta\",\"id\":\"Q9C0K7\"},{\"label\":\"Serine/threonine-protein kinase STK11\",\"id\":\"Q15831\"},{\"label\":\"Serine/threonine-protein kinase mTOR\",\"id\":\"P42345\"},{\"label\":\"Target of rapamycin complex subunit LST8\",\"id\":\"Q9BVC4\"},{\"label\":\"Tuberin\",\"id\":\"P49815\"}]", 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"[\"ALS2CR2\",\"AMPK\",\"AMPK1\",\"AMPK2\",\"AMPKG3\",\"C11orf59\",\"C7orf59\",\"CAB39\",\"CAB39L\",\"FRAP\",\"FRAP1\",\"FRAP2\",\"GBL\",\"HBXIP\",\"ILPIP\",\"KIAA0243\",\"KIAA1303\",\"LAMTOR1\",\"LAMTOR2\",\"LAMTOR3\",\"LAMTOR4\",\"LAMTOR5\",\"LKB1\",\"LST8\",\"LYK5\",\"MAP2K1IP1\",\"MAPBPIP\",\"MAPKSP1\",\"MLST8\",\"MO25\",\"MTOR\",\"PDRO\",\"PJS\",\"PPM1A\",\"PPPM1A\",\"PRKAA1\",\"PRKAA2\",\"PRKAB1\",\"PRKAB2\",\"PRKAG1\",\"PRKAG2\",\"PRKAG3\",\"RAFT1\",\"RAPT1\",\"RAPTOR\",\"RHEB\",\"RHEB2\",\"ROBLD3\",\"RPTOR\",\"RRAGA\",\"RRAGB\",\"RRAGC\",\"RRAGD\",\"SLC38A9\",\"STK11\",\"STRAD\",\"STRADA\",\"STRADB\",\"TSC\",\"TSC1\",\"TSC2\",\"TSC4\",\"URLC11\",\"XIP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Maturation of protein M", "protein_name": "[{\"label\":\"Membrane protein\",\"id\":\"P0DTC5\"}]", "uniprot_id": "[\"P0DTC5\"]", "gene_symbol": "[\"M\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "protein_name": "[{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Interferon regulatory factor 3\",\"id\":\"Q14653\"},{\"label\":\"Leucine-rich repeat flightless-interacting protein 1\",\"id\":\"Q32MZ4\"}]", "uniprot_id": "[\"P35222\",\"Q09472\",\"Q14653\",\"Q32MZ4\",\"Q92793\"]", "gene_symbol": "[\"CBP\",\"CREBBP\",\"CTNNB\",\"CTNNB1\",\"EP300\",\"GCF2\",\"IRF3\",\"LRRFIP1\",\"P300\",\"TRIP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "protein_name": "[{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"}]", "uniprot_id": "[\"Q8NDV7\",\"Q9H9G7\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9UPQ9\"]", "gene_symbol": "[\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"CAGH26\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"KIAA1631\",\"MOV10\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SARS-CoV-2 modulates host translation machinery", "protein_name": "[{\"label\":\"Gem-associated protein 2\",\"id\":\"O14893\"},{\"label\":\"Gem-associated protein 4\",\"id\":\"P57678\"},{\"label\":\"Gem-associated protein 5\",\"id\":\"Q8TEQ6\"},{\"label\":\"Gem-associated protein 6\",\"id\":\"Q8WXD5\"},{\"label\":\"Gem-associated protein 7\",\"id\":\"Q9H840\"},{\"label\":\"Gem-associated protein 8\",\"id\":\"Q9NWZ8\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX20\",\"id\":\"Q9UHI6\"},{\"label\":\"Replicase polyprotein 1a\",\"id\":\"P0DTC1\"},{\"label\":\"Replicase polyprotein 1ab\",\"id\":\"P0DTD1\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Small nuclear ribonucleoprotein E\",\"id\":\"P62304\"},{\"label\":\"Small nuclear ribonucleoprotein F\",\"id\":\"P62306\"},{\"label\":\"Small nuclear ribonucleoprotein G\",\"id\":\"P62308\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D1\",\"id\":\"P62314\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D2\",\"id\":\"P62316\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D3\",\"id\":\"P62318\"},{\"label\":\"Small nuclear ribonucleoprotein-associated proteins B and B'\",\"id\":\"P14678\"},{\"label\":\"Small ribosomal subunit protein eS10\",\"id\":\"P46783\"},{\"label\":\"Small ribosomal subunit protein eS12\",\"id\":\"P25398\"},{\"label\":\"Small ribosomal subunit protein eS17\",\"id\":\"P08708\"},{\"label\":\"Small ribosomal subunit protein eS19\",\"id\":\"P39019\"},{\"label\":\"Small ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS4, X isoform\",\"id\":\"P62701\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 1\",\"id\":\"P22090\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 2\",\"id\":\"Q8TD47\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein eS7\",\"id\":\"P62081\"},{\"label\":\"Small ribosomal subunit protein eS8\",\"id\":\"P62241\"},{\"label\":\"Small ribosomal subunit protein uS10\",\"id\":\"P60866\"},{\"label\":\"Small ribosomal subunit protein uS11\",\"id\":\"P62263\"},{\"label\":\"Small ribosomal subunit protein uS12\",\"id\":\"P62266\"},{\"label\":\"Small ribosomal subunit protein uS13\",\"id\":\"P62269\"},{\"label\":\"Small ribosomal subunit protein uS14\",\"id\":\"P62273\"},{\"label\":\"Small ribosomal subunit protein uS15\",\"id\":\"P62277\"},{\"label\":\"Small ribosomal subunit protein uS17\",\"id\":\"P62280\"},{\"label\":\"Small ribosomal subunit protein uS19\",\"id\":\"P62841\"},{\"label\":\"Small ribosomal subunit protein uS2\",\"id\":\"P08865\"},{\"label\":\"Small ribosomal subunit protein uS3\",\"id\":\"P23396\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small ribosomal subunit protein uS7\",\"id\":\"P46782\"},{\"label\":\"Small ribosomal subunit protein uS8\",\"id\":\"P62244\"},{\"label\":\"Small ribosomal subunit protein uS9\",\"id\":\"P62249\"},{\"label\":\"Survival motor neuron protein\",\"id\":\"Q16637\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O14893\",\"P08708\",\"P08865\",\"P0DTC1\",\"P0DTD1\",\"P14678\",\"P15880\",\"P22090\",\"P23396\",\"P25398\",\"P39019\",\"P42677\",\"P46781\",\"P46782\",\"P46783\",\"P57678\",\"P60866\",\"P61247\",\"P62081\",\"P62241\",\"P62244\",\"P62249\",\"P62263\",\"P62266\",\"P62269\",\"P62273\",\"P62277\",\"P62280\",\"P62304\",\"P62306\",\"P62308\",\"P62314\",\"P62316\",\"P62318\",\"P62701\",\"P62753\",\"P62841\",\"P62847\",\"P62851\",\"P62854\",\"P62857\",\"P62861\",\"P62979\",\"P63220\",\"Q16637\",\"Q71UM5\",\"Q8TD47\",\"Q8TEQ6\",\"Q8WXD5\",\"Q9H840\",\"Q9NWZ8\",\"Q9UHI6\"]", "gene_symbol": "[\"CCG2\",\"COD\",\"D6S218E\",\"DDX20\",\"DP103\",\"FAM51A1\",\"FAU\",\"FTE1\",\"GEMIN2\",\"GEMIN3\",\"GEMIN4\",\"GEMIN5\",\"GEMIN6\",\"GEMIN7\",\"GEMIN8\",\"LAMBR\",\"LAMR1\",\"MFTL\",\"MPS1\",\"PBSCF\",\"PBSCG\",\"RIG\",\"RPS10\",\"RPS11\",\"RPS12\",\"RPS13\",\"RPS14\",\"RPS15\",\"RPS15A\",\"RPS16\",\"RPS17\",\"RPS17L\",\"RPS18\",\"RPS19\",\"RPS2\",\"RPS20\",\"RPS21\",\"RPS23\",\"RPS24\",\"RPS25\",\"RPS26\",\"RPS27\",\"RPS27A\",\"RPS27L\",\"RPS28\",\"RPS29\",\"RPS3\",\"RPS3A\",\"RPS4\",\"RPS4X\",\"RPS4Y\",\"RPS4Y1\",\"RPS4Y2\",\"RPS4Y2P\",\"RPS5\",\"RPS6\",\"RPS7\",\"RPS8\",\"RPS9\",\"RPSA\",\"SCAR\",\"SIP1\",\"SMN\",\"SMN1\",\"SMN2\",\"SMNC\",\"SMNT\",\"SNRPB\",\"SNRPB1\",\"SNRPD1\",\"SNRPD2\",\"SNRPD3\",\"SNRPE\",\"SNRPF\",\"SNRPG\",\"UBA80\",\"UBCEP1\",\"rep\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TRKA activation by NGF", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"High affinity nerve growth factor receptor\",\"id\":\"P04629\"}]", "uniprot_id": "[\"P01138\",\"P04629\"]", "gene_symbol": "[\"MTC\",\"NGF\",\"NGFB\",\"NTRK1\",\"TRK\",\"TRKA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NrCAM interactions", "protein_name": "[{\"label\":\"Ankyrin-1\",\"id\":\"P16157\"},{\"label\":\"Contactin-2\",\"id\":\"Q02246\"},{\"label\":\"Disks large homolog 1\",\"id\":\"Q12959\"},{\"label\":\"Disks large homolog 3\",\"id\":\"Q92796\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Neuronal cell adhesion molecule\",\"id\":\"Q92823\"},{\"label\":\"Neuropilin-2\",\"id\":\"O60462\"}]", "uniprot_id": "[\"O60462\",\"P16157\",\"P78352\",\"Q02246\",\"Q12959\",\"Q92796\",\"Q92823\"]", "gene_symbol": "[\"ANK\",\"ANK1\",\"AXT\",\"CNTN2\",\"DLG1\",\"DLG3\",\"DLG4\",\"KIAA0343\",\"KIAA1232\",\"NRCAM\",\"NRP2\",\"PSD95\",\"TAG1\",\"TAX1\",\"VEGF165R2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "WNT mediated activation of DVL", "protein_name": "[{\"label\":\"Casein kinase I isoform epsilon\",\"id\":\"P49674\"},{\"label\":\"Casein kinase II subunit alpha'\",\"id\":\"P19784\"},{\"label\":\"Casein kinase II subunit alpha\",\"id\":\"P68400\"},{\"label\":\"Casein kinase II subunit beta\",\"id\":\"P67870\"},{\"label\":\"Phosphatidylinositol 4-phosphate 5-kinase type-1 beta\",\"id\":\"O14986\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-1\",\"id\":\"O14640\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-2\",\"id\":\"O14641\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-3\",\"id\":\"Q92997\"}]", "uniprot_id": "[\"O14640\",\"O14641\",\"O14986\",\"P19784\",\"P49674\",\"P67870\",\"P68400\",\"Q92997\"]", "gene_symbol": "[\"CK2A1\",\"CK2A2\",\"CK2N\",\"CSNK1E\",\"CSNK2A1\",\"CSNK2A2\",\"CSNK2B\",\"DVL1\",\"DVL2\",\"DVL3\",\"G5A\",\"KIAA0208\",\"PIP5K1B\",\"STM7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcription of the HIV genome", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIE subunit 1\",\"id\":\"P29083\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"TATA-binding protein-associated factor 2N\",\"id\":\"Q92804\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription initiation factor IIA subunit 1\",\"id\":\"P52655\"},{\"label\":\"Transcription initiation factor IIA subunit 2\",\"id\":\"P52657\"},{\"label\":\"Transcription initiation factor IIB\",\"id\":\"Q00403\"},{\"label\":\"Transcription initiation factor IIE subunit beta\",\"id\":\"P29084\"},{\"label\":\"Transcription initiation factor TFIID subunit 1-like\",\"id\":\"Q8IZX4\"},{\"label\":\"Transcription initiation factor TFIID subunit 10\",\"id\":\"Q12962\"},{\"label\":\"Transcription initiation factor TFIID subunit 11\",\"id\":\"Q15544\"},{\"label\":\"Transcription initiation factor TFIID subunit 12\",\"id\":\"Q16514\"},{\"label\":\"Transcription initiation factor TFIID subunit 13\",\"id\":\"Q15543\"},{\"label\":\"Transcription initiation factor TFIID subunit 1\",\"id\":\"P21675\"},{\"label\":\"Transcription initiation factor TFIID subunit 2\",\"id\":\"Q6P1X5\"},{\"label\":\"Transcription initiation factor TFIID subunit 3\",\"id\":\"Q5VWG9\"},{\"label\":\"Transcription initiation factor TFIID subunit 4\",\"id\":\"O00268\"},{\"label\":\"Transcription initiation factor TFIID subunit 4B\",\"id\":\"Q92750\"},{\"label\":\"Transcription initiation factor TFIID subunit 5\",\"id\":\"Q15542\"},{\"label\":\"Transcription initiation factor TFIID subunit 6\",\"id\":\"P49848\"},{\"label\":\"Transcription initiation factor TFIID subunit 7-like\",\"id\":\"Q5H9L4\"},{\"label\":\"Transcription initiation factor TFIID subunit 7\",\"id\":\"Q15545\"},{\"label\":\"Transcription initiation factor TFIID subunit 9\",\"id\":\"Q16594\"},{\"label\":\"Transcription initiation factor TFIID subunit 9B\",\"id\":\"Q9HBM6\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members", "protein_name": "[{\"label\":\"Apoptosis regulator Bcl-2\",\"id\":\"P10415\"},{\"label\":\"BH3-interacting domain death agonist\",\"id\":\"P55957\"},{\"label\":\"Bcl-2-binding component 3, isoforms 1/2\",\"id\":\"Q9BXH1\"},{\"label\":\"Bcl-2-like protein 11\",\"id\":\"O43521\"},{\"label\":\"Bcl-2-like protein 1\",\"id\":\"Q07817\"},{\"label\":\"Bcl-2-modifying factor\",\"id\":\"Q96LC9\"},{\"label\":\"Bcl2-associated agonist of cell death\",\"id\":\"Q92934\"},{\"label\":\"Phorbol-12-myristate-13-acetate-induced protein 1\",\"id\":\"Q13794\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"}]", "uniprot_id": "[\"O43521\",\"P10415\",\"P40763\",\"P55957\",\"Q07817\",\"Q13794\",\"Q92934\",\"Q96LC9\",\"Q9BXH1\"]", "gene_symbol": "[\"APRF\",\"BAD\",\"BBC3\",\"BBC6\",\"BCL2\",\"BCL2L\",\"BCL2L1\",\"BCL2L11\",\"BCL2L8\",\"BCLX\",\"BID\",\"BIM\",\"BMF\",\"NOXA\",\"PMAIP1\",\"PUMA\",\"STAT3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Proteasome assembly", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 10\",\"id\":\"O75832\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 4\",\"id\":\"P55036\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 5\",\"id\":\"Q16401\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 9\",\"id\":\"O00233\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Proteasomal ATPase-associated factor 1\",\"id\":\"Q9BRP4\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome activator complex subunit 1\",\"id\":\"Q06323\"},{\"label\":\"Proteasome activator complex subunit 2\",\"id\":\"Q9UL46\"},{\"label\":\"Proteasome activator complex subunit 3\",\"id\":\"P61289\"},{\"label\":\"Proteasome activator complex subunit 4\",\"id\":\"Q14997\"},{\"label\":\"Proteasome assembly chaperone 1\",\"id\":\"O95456\"},{\"label\":\"Proteasome assembly chaperone 2\",\"id\":\"Q969U7\"},{\"label\":\"Proteasome assembly chaperone 3\",\"id\":\"Q9BT73\"},{\"label\":\"Proteasome assembly chaperone 4\",\"id\":\"Q5JS54\"},{\"label\":\"Proteasome inhibitor PI31 subunit\",\"id\":\"Q92530\"},{\"label\":\"Proteasome maturation protein\",\"id\":\"Q9Y244\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)", "protein_name": "[{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 1\",\"id\":\"P11166\"}]", "uniprot_id": "[\"P11166\"]", "gene_symbol": "[\"GLUT1\",\"SLC2A1\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "Kinesins", "protein_name": "[{\"label\":\"Centromere-associated protein E\",\"id\":\"Q02224\"},{\"label\":\"Chromosome-associated kinesin KIF4A\",\"id\":\"O95239\"},{\"label\":\"Chromosome-associated kinesin KIF4B\",\"id\":\"Q2VIQ3\"},{\"label\":\"Kinesin heavy chain isoform 5A\",\"id\":\"Q12840\"},{\"label\":\"Kinesin light chain 1\",\"id\":\"Q07866\"},{\"label\":\"Kinesin light chain 2\",\"id\":\"Q9H0B6\"},{\"label\":\"Kinesin light chain 3\",\"id\":\"Q6P597\"},{\"label\":\"Kinesin light chain 4\",\"id\":\"Q9NSK0\"},{\"label\":\"Kinesin-1 heavy chain\",\"id\":\"P33176\"},{\"label\":\"Kinesin-associated protein 3\",\"id\":\"Q92845\"},{\"label\":\"Kinesin-like protein (Fragment)\",\"id\":\"Q66K46\"},{\"label\":\"Kinesin-like protein (Fragment)\",\"id\":\"Q6PKD1\"},{\"label\":\"Kinesin-like protein KIF11\",\"id\":\"P52732\"},{\"label\":\"Kinesin-like protein KIF12\",\"id\":\"Q96FN5\"},{\"label\":\"Kinesin-like protein KIF13B\",\"id\":\"Q9NQT8\"},{\"label\":\"Kinesin-like protein KIF15\",\"id\":\"Q9NS87\"},{\"label\":\"Kinesin-like protein KIF16B\",\"id\":\"Q96L93\"},{\"label\":\"Kinesin-like protein KIF18A\",\"id\":\"Q8NI77\"},{\"label\":\"Kinesin-like protein KIF18B\",\"id\":\"Q86Y91\"},{\"label\":\"Kinesin-like protein KIF19\",\"id\":\"Q2TAC6\"},{\"label\":\"Kinesin-like protein KIF1A\",\"id\":\"Q12756\"},{\"label\":\"Kinesin-like protein KIF1B\",\"id\":\"O60333\"},{\"label\":\"Kinesin-like protein KIF1C\",\"id\":\"O43896\"},{\"label\":\"Kinesin-like protein KIF20A\",\"id\":\"O95235\"},{\"label\":\"Kinesin-like protein KIF20B\",\"id\":\"Q96Q89\"},{\"label\":\"Kinesin-like protein KIF21A\",\"id\":\"Q7Z4S6\"},{\"label\":\"Kinesin-like protein KIF21B\",\"id\":\"O75037\"},{\"label\":\"Kinesin-like protein KIF22\",\"id\":\"Q14807\"},{\"label\":\"Kinesin-like protein KIF23\",\"id\":\"Q02241\"},{\"label\":\"Kinesin-like protein KIF25\",\"id\":\"Q9UIL4\"},{\"label\":\"Kinesin-like protein KIF26A\",\"id\":\"Q9ULI4\"},{\"label\":\"Kinesin-like protein KIF26B\",\"id\":\"Q2KJY2\"},{\"label\":\"Kinesin-like protein KIF27\",\"id\":\"Q86VH2\"},{\"label\":\"Kinesin-like protein KIF28P\",\"id\":\"B7ZC32\"},{\"label\":\"Kinesin-like protein KIF2A\",\"id\":\"O00139\"},{\"label\":\"Kinesin-like protein KIF2B\",\"id\":\"Q8N4N8\"},{\"label\":\"Kinesin-like protein KIF2C\",\"id\":\"Q99661\"},{\"label\":\"Kinesin-like protein KIF3A\",\"id\":\"Q9Y496\"},{\"label\":\"Kinesin-like protein KIF3B\",\"id\":\"O15066\"},{\"label\":\"Kinesin-like protein KIF3C\",\"id\":\"O14782\"},{\"label\":\"Kinesin-like protein KIF6\",\"id\":\"Q6ZMV9\"},{\"label\":\"Kinesin-like protein KIF9\",\"id\":\"Q9HAQ2\"},{\"label\":\"Kinesin-like protein KIFC1\",\"id\":\"Q9BW19\"},{\"label\":\"Kinesin-like protein KIFC2\",\"id\":\"Q96AC6\"},{\"label\":\"Rac GTPase-activating protein 1\",\"id\":\"Q9H0H5\"}]", "uniprot_id": "[\"B7ZC32\",\"O00139\",\"O14782\",\"O15066\",\"O43896\",\"O60333\",\"O75037\",\"O95235\",\"O95239\",\"P33176\",\"P52732\",\"Q02224\",\"Q02241\",\"Q07866\",\"Q12756\",\"Q12840\",\"Q14807\",\"Q2KJY2\",\"Q2TAC6\",\"Q2VIQ3\",\"Q66K46\",\"Q6P597\",\"Q6PKD1\",\"Q6ZMV9\",\"Q7Z4S6\",\"Q86VH2\",\"Q86Y91\",\"Q8N4N8\",\"Q8NI77\",\"Q92845\",\"Q96AC6\",\"Q96FN5\",\"Q96L93\",\"Q96Q89\",\"Q99661\",\"Q9BW19\",\"Q9H0B6\",\"Q9H0H5\",\"Q9HAQ2\",\"Q9NQT8\",\"Q9NS87\",\"Q9NSK0\",\"Q9UIL4\",\"Q9ULI4\",\"Q9Y496\"]", "gene_symbol": 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"Purine ribonucleoside monophosphate biosynthesis", "protein_name": "[{\"label\":\"Adenylosuccinate lyase\",\"id\":\"P30566\"},{\"label\":\"Adenylosuccinate synthetase isozyme 1\",\"id\":\"Q8N142\"},{\"label\":\"Adenylosuccinate synthetase isozyme 2\",\"id\":\"P30520\"},{\"label\":\"Amidophosphoribosyltransferase\",\"id\":\"Q06203\"},{\"label\":\"Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase\",\"id\":\"P22234\"},{\"label\":\"Bifunctional purine biosynthesis protein ATIC\",\"id\":\"P31939\"},{\"label\":\"GMP synthase [glutamine-hydrolyzing]\",\"id\":\"P49915\"},{\"label\":\"Inosine-5'-monophosphate dehydrogenase 1\",\"id\":\"P20839\"},{\"label\":\"Inosine-5'-monophosphate dehydrogenase 2\",\"id\":\"P12268\"},{\"label\":\"Phosphoribosylformylglycinamidine synthase\",\"id\":\"O15067\"},{\"label\":\"Trifunctional purine biosynthetic protein adenosine-3\",\"id\":\"P22102\"}]", "uniprot_id": "[\"O15067\",\"P12268\",\"P20839\",\"P22102\",\"P22234\",\"P30520\",\"P30566\",\"P31939\",\"P49915\",\"Q06203\",\"Q8N142\"]", "gene_symbol": "[\"ADE2\",\"ADSL\",\"ADSS\",\"ADSS1\",\"ADSS2\",\"ADSSL1\",\"AIRC\",\"AMPS\",\"ATIC\",\"GART\",\"GMPS\",\"GPAT\",\"IMPD1\",\"IMPD2\",\"IMPDH1\",\"IMPDH2\",\"KIAA0361\",\"PAICS\",\"PAIS\",\"PFAS\",\"PGFT\",\"PPAT\",\"PRGS\",\"PURH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MTOR signalling", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"GTP-binding protein Rheb\",\"id\":\"Q15382\"},{\"label\":\"Neutral amino acid transporter 9\",\"id\":\"Q8NBW4\"},{\"label\":\"Proline-rich AKT1 substrate 1\",\"id\":\"Q96B36\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"Ragulator complex protein LAMTOR1\",\"id\":\"Q6IAA8\"},{\"label\":\"Ragulator complex protein LAMTOR2\",\"id\":\"Q9Y2Q5\"},{\"label\":\"Ragulator complex protein LAMTOR3\",\"id\":\"Q9UHA4\"},{\"label\":\"Ragulator complex protein LAMTOR4\",\"id\":\"Q0VGL1\"},{\"label\":\"Ragulator complex protein LAMTOR5\",\"id\":\"O43504\"},{\"label\":\"Ras-related GTP-binding protein A\",\"id\":\"Q7L523\"},{\"label\":\"Ras-related GTP-binding protein B\",\"id\":\"Q5VZM2\"},{\"label\":\"Ras-related GTP-binding protein C\",\"id\":\"Q9HB90\"},{\"label\":\"Ras-related GTP-binding protein D\",\"id\":\"Q9NQL2\"},{\"label\":\"Regulatory-associated protein of mTOR\",\"id\":\"Q8N122\"},{\"label\":\"Serine/threonine-protein kinase mTOR\",\"id\":\"P42345\"},{\"label\":\"Target of rapamycin complex subunit LST8\",\"id\":\"Q9BVC4\"}]", "uniprot_id": "[\"O43504\",\"P31749\",\"P31946\",\"P42345\",\"Q0VGL1\",\"Q15382\",\"Q5VZM2\",\"Q6IAA8\",\"Q7L523\",\"Q8N122\",\"Q8NBW4\",\"Q96B36\",\"Q9BVC4\",\"Q9HB90\",\"Q9NQL2\",\"Q9UHA4\",\"Q9Y2Q5\"]", "gene_symbol": "[\"AKT1\",\"AKT1S1\",\"C11orf59\",\"C7orf59\",\"FRAP\",\"FRAP1\",\"FRAP2\",\"GBL\",\"HBXIP\",\"KIAA1303\",\"LAMTOR1\",\"LAMTOR2\",\"LAMTOR3\",\"LAMTOR4\",\"LAMTOR5\",\"LST8\",\"MAP2K1IP1\",\"MAPBPIP\",\"MAPKSP1\",\"MLST8\",\"MTOR\",\"PDRO\",\"PKB\",\"PRAS40\",\"RAC\",\"RAFT1\",\"RAPT1\",\"RAPTOR\",\"RHEB\",\"RHEB2\",\"ROBLD3\",\"RPTOR\",\"RRAGA\",\"RRAGB\",\"RRAGC\",\"RRAGD\",\"SLC38A9\",\"URLC11\",\"XIP\",\"YWHAB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ion channel transport", "protein_name": "[{\"label\":\"V-type proton ATPase 116 kDa subunit a 1\",\"id\":\"Q93050\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 2\",\"id\":\"Q9Y487\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 3\",\"id\":\"Q13488\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 4\",\"id\":\"Q9HBG4\"},{\"label\":\"V-type proton ATPase 16 kDa proteolipid subunit c\",\"id\":\"P27449\"},{\"label\":\"V-type proton ATPase 21 kDa proteolipid subunit c''\",\"id\":\"Q99437\"},{\"label\":\"V-type proton ATPase catalytic subunit A\",\"id\":\"P38606\"},{\"label\":\"V-type proton ATPase subunit B, brain isoform\",\"id\":\"P21281\"},{\"label\":\"V-type proton ATPase subunit B, kidney isoform\",\"id\":\"P15313\"},{\"label\":\"V-type proton ATPase subunit C 1\",\"id\":\"P21283\"},{\"label\":\"V-type proton ATPase subunit C 2\",\"id\":\"Q8NEY4\"},{\"label\":\"V-type proton ATPase subunit D\",\"id\":\"Q9Y5K8\"},{\"label\":\"V-type proton ATPase subunit E 1\",\"id\":\"P36543\"},{\"label\":\"V-type proton ATPase subunit E 2\",\"id\":\"Q96A05\"},{\"label\":\"V-type proton ATPase subunit F\",\"id\":\"Q16864\"},{\"label\":\"V-type proton ATPase subunit G 1\",\"id\":\"O75348\"},{\"label\":\"V-type proton ATPase subunit G 2\",\"id\":\"O95670\"},{\"label\":\"V-type proton ATPase subunit G 3\",\"id\":\"Q96LB4\"},{\"label\":\"V-type proton ATPase subunit H\",\"id\":\"Q9UI12\"},{\"label\":\"V-type proton ATPase subunit S1\",\"id\":\"Q15904\"},{\"label\":\"V-type proton ATPase subunit d 1\",\"id\":\"P61421\"},{\"label\":\"V-type proton ATPase subunit d 2\",\"id\":\"Q8N8Y2\"},{\"label\":\"V-type proton ATPase subunit e 1\",\"id\":\"O15342\"},{\"label\":\"V-type proton ATPase subunit e 2\",\"id\":\"Q8NHE4\"}]", "uniprot_id": "[\"O15342\",\"O75348\",\"O95670\",\"P15313\",\"P21281\",\"P21283\",\"P27449\",\"P36543\",\"P38606\",\"P61421\",\"Q13488\",\"Q15904\",\"Q16864\",\"Q8N8Y2\",\"Q8NEY4\",\"Q8NHE4\",\"Q93050\",\"Q96A05\",\"Q96LB4\",\"Q99437\",\"Q9HBG4\",\"Q9UI12\",\"Q9Y487\",\"Q9Y5K8\"]", "gene_symbol": 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2\",\"id\":\"P09038\"},{\"label\":\"Forkhead box protein C1\",\"id\":\"Q12948\"},{\"label\":\"Forkhead box protein C2\",\"id\":\"Q99958\"},{\"label\":\"LIM/homeobox protein Lhx1\",\"id\":\"P48742\"},{\"label\":\"Paired box protein Pax-2\",\"id\":\"Q02962\"},{\"label\":\"Paired box protein Pax-8\",\"id\":\"Q06710\"},{\"label\":\"Protein odd-skipped-related 1\",\"id\":\"Q8TAX0\"}]", "uniprot_id": "[\"P09038\",\"P12644\",\"P48742\",\"Q02962\",\"Q06710\",\"Q12948\",\"Q8TAX0\",\"Q99958\"]", "gene_symbol": "[\"BMP2B\",\"BMP4\",\"DVR4\",\"FGF2\",\"FGFB\",\"FKHL14\",\"FKHL7\",\"FOXC1\",\"FOXC2\",\"FREAC3\",\"LHX1\",\"LIM-1\",\"LIM1\",\"MFH1\",\"ODD\",\"OSR1\",\"PAX2\",\"PAX8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Abacavir transmembrane transport", "protein_name": "[{\"label\":\"ATP-dependent translocase ABCB1\",\"id\":\"P08183\"},{\"label\":\"Broad substrate specificity ATP-binding cassette transporter ABCG2\",\"id\":\"Q9UNQ0\"},{\"label\":\"Solute carrier family 22 member 1\",\"id\":\"O15245\"},{\"label\":\"Solute carrier family 22 member 2\",\"id\":\"O15244\"},{\"label\":\"Solute carrier family 22 member 3\",\"id\":\"O75751\"}]", "uniprot_id": "[\"O15244\",\"O15245\",\"O75751\",\"P08183\",\"Q9UNQ0\"]", "gene_symbol": "[\"ABCB1\",\"ABCG2\",\"ABCP\",\"BCRP\",\"BCRP1\",\"EMTH\",\"MDR1\",\"MXR\",\"OCT1\",\"OCT2\",\"OCT3\",\"PGY1\",\"SLC22A1\",\"SLC22A2\",\"SLC22A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "tRNA modification in the mitochondrion", "protein_name": "[{\"label\":\"3-hydroxyacyl-CoA dehydrogenase type-2\",\"id\":\"Q99714\"},{\"label\":\"Mitochondrial ribonuclease P catalytic subunit\",\"id\":\"O15091\"},{\"label\":\"Mitochondrial tRNA-specific 2-thiouridylase 1\",\"id\":\"O75648\"},{\"label\":\"Protein MTO1 homolog, mitochondrial\",\"id\":\"Q9Y2Z2\"},{\"label\":\"tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial\",\"id\":\"Q9BVS5\"},{\"label\":\"tRNA dimethylallyltransferase\",\"id\":\"Q9H3H1\"},{\"label\":\"tRNA methyltransferase 10 homolog C\",\"id\":\"Q7L0Y3\"},{\"label\":\"tRNA modification GTPase GTPBP3, mitochondrial\",\"id\":\"Q969Y2\"}]", "uniprot_id": "[\"O15091\",\"O75648\",\"Q7L0Y3\",\"Q969Y2\",\"Q99714\",\"Q9BVS5\",\"Q9H3H1\",\"Q9Y2Z2\"]", "gene_symbol": "[\"ERAB\",\"GTPBP3\",\"HADH2\",\"HSD17B10\",\"IPT\",\"KIAA0391\",\"MOD5\",\"MRPP1\",\"MRPP2\",\"MRPP3\",\"MTGP1\",\"MTO1\",\"MTU1\",\"PRORP\",\"RG9MTD1\",\"SCHAD\",\"SDR5C1\",\"TRIT1\",\"TRMT1\",\"TRMT10C\",\"TRMT61B\",\"TRMU\",\"XH98G2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Creatine metabolism", "protein_name": "[{\"label\":\"Creatine kinase B-type\",\"id\":\"P12277\"},{\"label\":\"Creatine kinase M-type\",\"id\":\"P06732\"},{\"label\":\"Creatine kinase S-type, mitochondrial\",\"id\":\"P17540\"},{\"label\":\"Creatine kinase U-type, mitochondrial\",\"id\":\"P12532\"},{\"label\":\"Glycine amidinotransferase, mitochondrial\",\"id\":\"P50440\"},{\"label\":\"Guanidinoacetate N-methyltransferase\",\"id\":\"Q14353\"},{\"label\":\"Sodium- and chloride-dependent GABA transporter 3\",\"id\":\"P48066\"},{\"label\":\"Sodium- and chloride-dependent betaine transporter\",\"id\":\"P48065\"},{\"label\":\"Sodium- and chloride-dependent creatine transporter 1\",\"id\":\"P48029\"},{\"label\":\"Sodium-dependent proline transporter\",\"id\":\"Q99884\"}]", "uniprot_id": "[\"P06732\",\"P12277\",\"P12532\",\"P17540\",\"P48029\",\"P48065\",\"P48066\",\"P50440\",\"Q14353\",\"Q99884\"]", "gene_symbol": "[\"AGAT\",\"BGT1\",\"CKB\",\"CKBB\",\"CKM\",\"CKMM\",\"CKMT\",\"CKMT1A\",\"CKMT1B\",\"CKMT2\",\"GABT3\",\"GAMT\",\"GAT3\",\"GATM\",\"PROT\",\"SLC6A11\",\"SLC6A12\",\"SLC6A7\",\"SLC6A8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SCF-beta-TrCP mediated degradation of Emi1", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"F-box only protein 5\",\"id\":\"Q9UKT4\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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membrane", "protein_name": "[{\"label\":\"Amino acid transporter heavy chain SLC3A1\",\"id\":\"Q07837\"},{\"label\":\"Amino acid transporter heavy chain SLC3A2\",\"id\":\"P08195\"},{\"label\":\"Asc-type amino acid transporter 1\",\"id\":\"Q9NS82\"},{\"label\":\"Cationic amino acid transporter 3\",\"id\":\"Q8WY07\"},{\"label\":\"Cystine/glutamate transporter\",\"id\":\"Q9UPY5\"},{\"label\":\"High affinity cationic amino acid transporter 1\",\"id\":\"P30825\"},{\"label\":\"Inactive sodium-dependent neutral amino acid transporter B(0)AT3\",\"id\":\"Q96N87\"},{\"label\":\"Large neutral amino acids transporter small subunit 1\",\"id\":\"Q01650\"},{\"label\":\"Large neutral amino acids transporter small subunit 2\",\"id\":\"Q9UHI5\"},{\"label\":\"Large neutral amino acids transporter small subunit 3\",\"id\":\"O75387\"},{\"label\":\"Large neutral amino acids transporter small subunit 4\",\"id\":\"Q8N370\"},{\"label\":\"Mitochondrial basic amino acids transporter\",\"id\":\"Q8N8R3\"},{\"label\":\"Monocarboxylate transporter 10\",\"id\":\"Q8TF71\"},{\"label\":\"Neutral amino acid transporter A\",\"id\":\"P43007\"},{\"label\":\"Neutral amino acid transporter B(0)\",\"id\":\"Q15758\"},{\"label\":\"Neutral amino acid uniporter 4\",\"id\":\"Q6YBV0\"},{\"label\":\"Proton-coupled amino acid transporter 1\",\"id\":\"Q7Z2H8\"},{\"label\":\"Proton-coupled amino acid transporter 2\",\"id\":\"Q495M3\"},{\"label\":\"Sodium- and chloride-dependent betaine transporter\",\"id\":\"P48065\"},{\"label\":\"Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)\",\"id\":\"Q9UN76\"},{\"label\":\"Sodium- and chloride-dependent taurine transporter\",\"id\":\"P31641\"},{\"label\":\"Sodium- and chloride-dependent transporter XTRP3\",\"id\":\"Q9NP91\"},{\"label\":\"Sodium-coupled neutral amino acid symporter 1\",\"id\":\"Q9H2H9\"},{\"label\":\"Sodium-coupled neutral amino acid symporter 2\",\"id\":\"Q96QD8\"},{\"label\":\"Sodium-coupled neutral amino acid transporter 3\",\"id\":\"Q99624\"},{\"label\":\"Sodium-coupled neutral amino acid transporter 4\",\"id\":\"Q969I6\"},{\"label\":\"Sodium-coupled neutral amino acid transporter 5\",\"id\":\"Q8WUX1\"},{\"label\":\"Sodium-dependent neutral amino acid transporter B(0)AT1\",\"id\":\"Q695T7\"},{\"label\":\"Sodium-dependent neutral amino acid transporter B(0)AT2\",\"id\":\"Q9H2J7\"},{\"label\":\"Y+L amino acid transporter 1\",\"id\":\"Q9UM01\"},{\"label\":\"Y+L amino acid transporter 2\",\"id\":\"Q92536\"},{\"label\":\"b(0,+)-type amino acid transporter 1\",\"id\":\"P82251\"}]", "uniprot_id": "[\"O75387\",\"P08195\",\"P30825\",\"P31641\",\"P43007\",\"P48065\",\"P82251\",\"Q01650\",\"Q07837\",\"Q15758\",\"Q495M3\",\"Q695T7\",\"Q6YBV0\",\"Q7Z2H8\",\"Q8N370\",\"Q8N8R3\",\"Q8TF71\",\"Q8WUX1\",\"Q8WY07\",\"Q92536\",\"Q969I6\",\"Q96N87\",\"Q96QD8\",\"Q99624\",\"Q9H2H9\",\"Q9H2J7\",\"Q9NP91\",\"Q9NS82\",\"Q9UHI5\",\"Q9UM01\",\"Q9UN76\",\"Q9UPY5\"]", "gene_symbol": "[\"ASC1\",\"ASCT1\",\"ASCT2\",\"ATA1\",\"ATA2\",\"ATA3\",\"ATRC1\",\"ATRC3\",\"B0AT1\",\"B0AT2\",\"B0AT3\",\"BAT1\",\"BGT1\",\"C14orf69\",\"CAT3\",\"CD98LC\",\"ERR\",\"G17\",\"JM24\",\"KIAA0245\",\"KIAA1382\",\"LAT1\",\"LAT2\",\"LAT3\",\"LAT4\",\"M7V1\",\"MCT10\",\"MDU1\",\"MPE16\",\"NAT1\",\"NAT2\",\"NAT3\",\"NBAT\",\"NTT73\",\"ORNT3\",\"PAT1\",\"PAT2\",\"PAT4\",\"PB39\",\"POV1\",\"RDR\",\"RDRC\",\"REC1L\",\"SAT1\",\"SAT2\",\"SATT\",\"SBAT1\",\"SIT1\",\"SLC16A10\",\"SLC1A4\",\"SLC1A5\",\"SLC25A29\",\"SLC36A1\",\"SLC36A2\",\"SLC36A4\",\"SLC38A1\",\"SLC38A2\",\"SLC38A3\",\"SLC38A4\",\"SLC38A5\",\"SLC3A1\",\"SLC3A2\",\"SLC43A1\",\"SLC43A2\",\"SLC6A12\",\"SLC6A14\",\"SLC6A15\",\"SLC6A18\",\"SLC6A19\",\"SLC6A20\",\"SLC6A6\",\"SLC7A1\",\"SLC7A10\",\"SLC7A11\",\"SLC7A3\",\"SLC7A5\",\"SLC7A6\",\"SLC7A7\",\"SLC7A8\",\"SLC7A9\",\"SN1\",\"SN2\",\"SNAT1\",\"SNAT2\",\"SNAT3\",\"SNAT4\",\"SNAT5\",\"TAT1\",\"TRAMD1\",\"XT3\",\"XTRP2\",\"XTRP3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective DPM2 causes CDG-1u", "protein_name": "[{\"label\":\"Dolichol phosphate-mannose biosynthesis regulatory protein\",\"id\":\"O94777\"},{\"label\":\"Dolichol-phosphate mannosyltransferase subunit 1\",\"id\":\"O60762\"},{\"label\":\"Dolichol-phosphate mannosyltransferase subunit 3\",\"id\":\"Q9P2X0\"}]", "uniprot_id": "[\"O60762\",\"O94777\",\"Q9P2X0\"]", "gene_symbol": "[\"DPM1\",\"DPM2\",\"DPM3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IRAK4 deficiency (TLR2/4)", "protein_name": "[{\"label\":\"Fibrinogen alpha chain\",\"id\":\"P02671\"},{\"label\":\"Fibrinogen beta chain\",\"id\":\"P02675\"},{\"label\":\"Fibrinogen gamma chain\",\"id\":\"P02679\"},{\"label\":\"High mobility group protein B1\",\"id\":\"P09429\"},{\"label\":\"Interleukin-1 receptor-associated kinase 4\",\"id\":\"Q9NWZ3\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Major outer membrane protein P.IB\",\"id\":\"P30690\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Myeloid differentiation primary response protein MyD88\",\"id\":\"Q99836\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase Mip\",\"id\":\"P26623\"},{\"label\":\"Platelet glycoprotein 4\",\"id\":\"P16671\"},{\"label\":\"Protein S100-A1\",\"id\":\"P23297\"},{\"label\":\"Protein S100-A8\",\"id\":\"P05109\"},{\"label\":\"Protein S100-A9\",\"id\":\"P06702\"},{\"label\":\"Toll-like receptor 1\",\"id\":\"Q15399\"},{\"label\":\"Toll-like receptor 2\",\"id\":\"O60603\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Toll-like receptor 6\",\"id\":\"Q9Y2C9\"},{\"label\":\"Toll/interleukin-1 receptor domain-containing adapter protein\",\"id\":\"P58753\"},{\"label\":\"Tyrosine-protein kinase BTK\",\"id\":\"Q06187\"}]", "uniprot_id": "[\"O00206\",\"O60603\",\"P02671\",\"P02675\",\"P02679\",\"P05109\",\"P06702\",\"P08571\",\"P09429\",\"P16671\",\"P23297\",\"P26623\",\"P30690\",\"P58753\",\"Q06187\",\"Q15399\",\"Q99836\",\"Q9NWZ3\",\"Q9Y2C9\",\"Q9Y6Y9\"]", "gene_symbol": "[\"AGMX1\",\"ATK\",\"BPK\",\"BTK\",\"CAGA\",\"CAGB\",\"CD14\",\"CD36\",\"CFAG\",\"ESOP1\",\"FGA\",\"FGB\",\"FGG\",\"GP3B\",\"GP4\",\"HMG1\",\"HMGB1\",\"IRAK4\",\"KIAA0012\",\"LY96\",\"MAL\",\"MD2\",\"MRP14\",\"MRP8\",\"MYD88\",\"S100A\",\"S100A1\",\"S100A8\",\"S100A9\",\"TIL4\",\"TIRAP\",\"TLR1\",\"TLR2\",\"TLR4\",\"TLR6\",\"mip\",\"porB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cysteine formation from homocysteine", "protein_name": "[{\"label\":\"Cystathionine beta-synthase\",\"id\":\"P35520\"},{\"label\":\"Cystathionine gamma-lyase\",\"id\":\"P32929\"}]", "uniprot_id": "[\"P32929\",\"P35520\"]", "gene_symbol": "[\"CBS\",\"CTH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Tat-mediated HIV elongation arrest and recovery", "protein_name": "[{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Elongin-A2\",\"id\":\"Q8IYF1\"},{\"label\":\"Elongin-A\",\"id\":\"Q14241\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"FACT complex subunit SPT16\",\"id\":\"Q9Y5B9\"},{\"label\":\"FACT complex subunit SSRP1\",\"id\":\"Q08945\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"Negative elongation factor A\",\"id\":\"Q9H3P2\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"},{\"label\":\"Negative elongation factor C/D\",\"id\":\"Q8IXH7\"},{\"label\":\"Negative elongation factor E\",\"id\":\"P18615\"},{\"label\":\"Protein Tat\",\"id\":\"P04608\"},{\"label\":\"RNA polymerase II elongation factor ELL\",\"id\":\"P55199\"},{\"label\":\"RNA polymerase II subunit A C-terminal domain phosphatase\",\"id\":\"Q9Y5B0\"},{\"label\":\"Transcription elongation factor A protein 1\",\"id\":\"P23193\"},{\"label\":\"Transcription elongation factor SPT4\",\"id\":\"P63272\"},{\"label\":\"Transcription elongation factor SPT5\",\"id\":\"O00267\"}]", "uniprot_id": "[\"O00267\",\"O15514\",\"O60563\",\"P04608\",\"P13984\",\"P18615\",\"P19387\",\"P19388\",\"P23193\",\"P24928\",\"P30876\",\"P35269\",\"P36954\",\"P50750\",\"P52434\",\"P52435\",\"P53803\",\"P55199\",\"P61218\",\"P62487\",\"P62875\",\"P63272\",\"Q08945\",\"Q14241\",\"Q15369\",\"Q15370\",\"Q8IXH7\",\"Q8IYF1\",\"Q8WX92\",\"Q9H3P2\",\"Q9Y5B0\",\"Q9Y5B9\"]", "gene_symbol": "[\"C19orf17\",\"CCNT1\",\"CDC2L4\",\"CDK9\",\"COBRA1\",\"CTDP1\",\"ELL\",\"ELOA\",\"ELOA2\",\"ELOB\",\"ELOC\",\"FACT140\",\"FACT80\",\"FACTP140\",\"FCP1\",\"GTF2F1\",\"GTF2F2\",\"GTF2S\",\"KIAA1182\",\"NELFA\",\"NELFB\",\"NELFCD\",\"NELFD\",\"NELFE\",\"POLR2\",\"POLR2A\",\"POLR2B\",\"POLR2C\",\"POLR2D\",\"POLR2E\",\"POLR2F\",\"POLR2G\",\"POLR2H\",\"POLR2I\",\"POLR2J\",\"POLR2J1\",\"POLR2K\",\"POLR2L\",\"POLRF\",\"RAP30\",\"RAP74\",\"RD\",\"RDBP\",\"RPB7\",\"SPT4H\",\"SPT5\",\"SPT5H\",\"SSRP1\",\"SUPT16H\",\"SUPT4H\",\"SUPT4H1\",\"SUPT5H\",\"TAK\",\"TCEA1\",\"TCEB1\",\"TCEB2\",\"TCEB3\",\"TCEB3B\",\"TCEB3L\",\"TFIIS\",\"TH1\",\"TH1L\",\"WHSC2\",\"tat\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cristae formation", "protein_name": "[{\"label\":\"ATP synthase F(0) complex subunit B1, mitochondrial\",\"id\":\"P24539\"},{\"label\":\"ATP synthase F(0) complex subunit C1, mitochondrial\",\"id\":\"P05496\"},{\"label\":\"ATP synthase F(0) complex subunit C2, mitochondrial\",\"id\":\"Q06055\"},{\"label\":\"ATP synthase F(0) complex subunit C3, mitochondrial\",\"id\":\"P48201\"},{\"label\":\"ATP synthase membrane subunit K, mitochondrial\",\"id\":\"Q96IX5\"},{\"label\":\"ATP synthase protein 8\",\"id\":\"P03928\"},{\"label\":\"ATP synthase subunit ATP5MJ, mitochondrial\",\"id\":\"P56378\"},{\"label\":\"ATP synthase subunit O, mitochondrial\",\"id\":\"P48047\"},{\"label\":\"ATP synthase subunit a\",\"id\":\"P00846\"},{\"label\":\"ATP synthase subunit alpha, mitochondrial\",\"id\":\"P25705\"},{\"label\":\"ATP synthase subunit beta, mitochondrial\",\"id\":\"P06576\"},{\"label\":\"ATP synthase subunit d, mitochondrial\",\"id\":\"O75947\"},{\"label\":\"ATP synthase subunit delta, mitochondrial\",\"id\":\"P30049\"},{\"label\":\"ATP synthase subunit e, mitochondrial\",\"id\":\"P56385\"},{\"label\":\"ATP synthase subunit epsilon, mitochondrial\",\"id\":\"P56381\"},{\"label\":\"ATP synthase subunit f, mitochondrial\",\"id\":\"P56134\"},{\"label\":\"ATP synthase subunit g, mitochondrial\",\"id\":\"O75964\"},{\"label\":\"ATP synthase subunit gamma, mitochondrial\",\"id\":\"P36542\"},{\"label\":\"ATP synthase subunit s, mitochondrial\",\"id\":\"Q99766\"},{\"label\":\"ATP synthase-coupling factor 6, mitochondrial\",\"id\":\"P18859\"},{\"label\":\"DnaJ homolog subfamily C member 11\",\"id\":\"Q9NVH1\"},{\"label\":\"MICOS complex subunit MIC10\",\"id\":\"Q5TGZ0\"},{\"label\":\"MICOS complex subunit MIC13\",\"id\":\"Q5XKP0\"},{\"label\":\"MICOS complex subunit MIC19\",\"id\":\"Q9NX63\"},{\"label\":\"MICOS complex subunit MIC25\",\"id\":\"Q9BRQ6\"},{\"label\":\"MICOS complex subunit MIC26\",\"id\":\"Q9BUR5\"},{\"label\":\"MICOS complex subunit MIC27\",\"id\":\"Q6UXV4\"},{\"label\":\"MICOS complex subunit MIC60\",\"id\":\"Q16891\"},{\"label\":\"Metaxin-1\",\"id\":\"Q13505\"},{\"label\":\"Metaxin-2\",\"id\":\"O75431\"},{\"label\":\"Sorting and assembly machinery component 50 homolog\",\"id\":\"Q9Y512\"},{\"label\":\"Stress-70 protein, mitochondrial\",\"id\":\"P38646\"},{\"label\":\"Transmembrane protein 11, mitochondrial\",\"id\":\"P17152\"}]", "uniprot_id": "[\"O75431\",\"O75947\",\"O75964\",\"P00846\",\"P03928\",\"P05496\",\"P06576\",\"P17152\",\"P18859\",\"P24539\",\"P25705\",\"P30049\",\"P36542\",\"P38646\",\"P48047\",\"P48201\",\"P56134\",\"P56378\",\"P56381\",\"P56385\",\"Q06055\",\"Q13505\",\"Q16891\",\"Q5TGZ0\",\"Q5XKP0\",\"Q6UXV4\",\"Q96IX5\",\"Q99766\",\"Q9BRQ6\",\"Q9BUR5\",\"Q9NVH1\",\"Q9NX63\",\"Q9Y512\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Transport of connexons to the plasma membrane", "protein_name": "[{\"label\":\"Gap junction beta-2 protein\",\"id\":\"P29033\"}]", "uniprot_id": "[\"P29033\"]", "gene_symbol": "[\"GJB2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ALK mutants bind TKIs", "protein_name": "[{\"label\":\"ALK tyrosine kinase receptor\",\"id\":\"Q9UM73\"},{\"label\":\"B-cell lymphoma/leukemia 11A\",\"id\":\"Q9H165\"},{\"label\":\"Baculoviral IAP repeat-containing protein 6\",\"id\":\"Q9NR09\"},{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Echinoderm microtubule-associated protein-like 4\",\"id\":\"Q9HC35\"},{\"label\":\"Eukaryotic translation initiation factor 2-alpha kinase 3\",\"id\":\"Q9NZJ5\"},{\"label\":\"Fibronectin\",\"id\":\"P02751\"},{\"label\":\"Huntingtin-interacting protein 1\",\"id\":\"O00291\"},{\"label\":\"Nucleophosmin\",\"id\":\"P06748\"},{\"label\":\"Protein phosphatase 1B\",\"id\":\"O75688\"},{\"label\":\"Striatin\",\"id\":\"O43815\"},{\"label\":\"cAMP-dependent protein kinase type I-alpha regulatory subunit\",\"id\":\"P10644\"}]", "uniprot_id": "[\"O00291\",\"O43815\",\"O75688\",\"P02751\",\"P06748\",\"P10644\",\"Q00610\",\"Q9H165\",\"Q9HC35\",\"Q9NR09\",\"Q9NZJ5\",\"Q9UM73\"]", "gene_symbol": "[\"ALK\",\"BCL11A\",\"BIRC6\",\"C2orf2\",\"CLH17\",\"CLTC\",\"CLTCL2\",\"CTIP1\",\"EIF2AK3\",\"EMAPL4\",\"EML4\",\"EVI9\",\"FN\",\"FN1\",\"HIP1\",\"KIAA0034\",\"KIAA1289\",\"KIAA1809\",\"NPM\",\"NPM1\",\"PEK\",\"PERK\",\"PKR1\",\"PP2CB\",\"PPM1B\",\"PRKAR1\",\"PRKAR1A\",\"STRN\",\"TSE1\",\"ZNF856\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase", "protein_name": "[{\"label\":\"Anaphase-promoting complex subunit 10\",\"id\":\"Q9UM13\"},{\"label\":\"Anaphase-promoting complex subunit 11\",\"id\":\"Q9NYG5\"},{\"label\":\"Anaphase-promoting complex subunit 15\",\"id\":\"P60006\"},{\"label\":\"Anaphase-promoting complex subunit 16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 5\",\"id\":\"Q9UJX4\"},{\"label\":\"Anaphase-promoting complex subunit 7\",\"id\":\"Q9UJX3\"},{\"label\":\"Anaphase-promoting complex subunit CDC26\",\"id\":\"Q8NHZ8\"},{\"label\":\"Cell division cycle protein 16 homolog\",\"id\":\"Q13042\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Cell division cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Dual specificity protein phosphatase CDC14A\",\"id\":\"Q9UNH5\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"}]", "uniprot_id": "[\"O00762\",\"P30260\",\"P51668\",\"P51965\",\"P60006\",\"Q12834\",\"Q13042\",\"Q16763\",\"Q8NHZ8\",\"Q96DE5\",\"Q9H1A4\",\"Q9NYG5\",\"Q9UJX2\",\"Q9UJX3\",\"Q9UJX4\",\"Q9UJX5\",\"Q9UJX6\",\"Q9UM11\",\"Q9UM13\",\"Q9UNH5\"]", "gene_symbol": 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gamma-carboxylase\",\"id\":\"P38435\"},{\"label\":\"Vitamin K-dependent protein C\",\"id\":\"P04070\"},{\"label\":\"Vitamin K-dependent protein S\",\"id\":\"P07225\"},{\"label\":\"Vitamin K-dependent protein Z\",\"id\":\"P22891\"}]", "uniprot_id": "[\"P00734\",\"P00740\",\"P00742\",\"P02818\",\"P04070\",\"P07225\",\"P08709\",\"P22891\",\"P38435\",\"Q14393\"]", "gene_symbol": "[\"AXLLG\",\"BGLAP\",\"F10\",\"F2\",\"F7\",\"F9\",\"GAS6\",\"GC\",\"GGCX\",\"PROC\",\"PROS\",\"PROS1\",\"PROZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Receptor-type tyrosine-protein phosphatases", "protein_name": "[{\"label\":\"Interleukin-1 receptor accessory protein-like 1\",\"id\":\"Q9NZN1\"},{\"label\":\"Leucine-rich repeat-containing protein 4B\",\"id\":\"Q9NT99\"},{\"label\":\"Liprin-alpha-1\",\"id\":\"Q13136\"},{\"label\":\"Liprin-alpha-2\",\"id\":\"O75334\"},{\"label\":\"Liprin-alpha-3\",\"id\":\"O75145\"},{\"label\":\"Liprin-alpha-4\",\"id\":\"O75335\"},{\"label\":\"Liprin-beta-1\",\"id\":\"Q86W92\"},{\"label\":\"Liprin-beta-2\",\"id\":\"Q8ND30\"},{\"label\":\"NT-3 growth factor receptor\",\"id\":\"Q16288\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase F\",\"id\":\"P10586\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase S\",\"id\":\"Q13332\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase delta\",\"id\":\"P23468\"},{\"label\":\"SLIT and NTRK-like protein 1\",\"id\":\"Q96PX8\"},{\"label\":\"SLIT and NTRK-like protein 2\",\"id\":\"Q9H156\"},{\"label\":\"SLIT and NTRK-like protein 3\",\"id\":\"O94933\"},{\"label\":\"SLIT and NTRK-like protein 4\",\"id\":\"Q8IW52\"},{\"label\":\"SLIT and NTRK-like protein 5\",\"id\":\"O94991\"},{\"label\":\"SLIT and NTRK-like protein 6\",\"id\":\"Q9H5Y7\"},{\"label\":\"X-linked interleukin-1 receptor accessory protein-like 2\",\"id\":\"Q9NP60\"}]", "uniprot_id": "[\"O75145\",\"O75334\",\"O75335\",\"O94933\",\"O94991\",\"P10586\",\"P23468\",\"Q13136\",\"Q13332\",\"Q16288\",\"Q86W92\",\"Q8IW52\",\"Q8ND30\",\"Q96PX8\",\"Q9H156\",\"Q9H5Y7\",\"Q9NP60\",\"Q9NT99\",\"Q9NZN1\"]", "gene_symbol": "[\"CXorf2\",\"IL1R9\",\"IL1RAPL1\",\"IL1RAPL2\",\"KIAA0654\",\"KIAA0848\",\"KIAA0897\",\"KIAA0918\",\"KIAA1230\",\"KIAA1854\",\"KIAA1910\",\"LAR\",\"LIP1\",\"LRIG4\",\"LRRC11\",\"LRRC12\",\"LRRC4B\",\"NTRK3\",\"OPHN4\",\"PPFIA1\",\"PPFIA2\",\"PPFIA3\",\"PPFIA4\",\"PPFIBP1\",\"PPFIBP2\",\"PTPRD\",\"PTPRF\",\"PTPRS\",\"SLITL1\",\"SLITRK1\",\"SLITRK2\",\"SLITRK3\",\"SLITRK4\",\"SLITRK5\",\"SLITRK6\",\"TRKC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Negative regulation of MAPK pathway", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"BRCA1-associated protein\",\"id\":\"Q7Z569\"},{\"label\":\"Dual specificity protein phosphatase 10\",\"id\":\"Q9Y6W6\"},{\"label\":\"Dual specificity protein phosphatase 16\",\"id\":\"Q9BY84\"},{\"label\":\"Dual specificity protein phosphatase 1\",\"id\":\"P28562\"},{\"label\":\"Dual specificity protein phosphatase 2\",\"id\":\"Q05923\"},{\"label\":\"Dual specificity protein phosphatase 4\",\"id\":\"Q13115\"},{\"label\":\"Dual specificity protein phosphatase 5\",\"id\":\"Q16690\"},{\"label\":\"Dual specificity protein phosphatase 6\",\"id\":\"Q16828\"},{\"label\":\"Dual specificity protein phosphatase 7\",\"id\":\"Q16829\"},{\"label\":\"Dual specificity protein phosphatase 8\",\"id\":\"Q13202\"},{\"label\":\"Dual specificity protein phosphatase 9\",\"id\":\"Q99956\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Kinase suppressor of Ras 1\",\"id\":\"Q8IVT5\"},{\"label\":\"MAP/microtubule affinity-regulating kinase 3\",\"id\":\"P27448\"},{\"label\":\"Mitogen-activated protein kinase 12\",\"id\":\"P53778\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Phosphatidylethanolamine-binding protein 1\",\"id\":\"P30086\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Progestin and adipoQ receptor family member 3\",\"id\":\"Q6TCH7\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"Serine/threonine-protein kinase A-Raf\",\"id\":\"P10398\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"Serine/threonine-protein phosphatase 5\",\"id\":\"P53041\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 3\",\"id\":\"P26045\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 7\",\"id\":\"P35236\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P04049\",\"P0CG47\",\"P0CG48\",\"P10398\",\"P15056\",\"P26045\",\"P27361\",\"P27448\",\"P28482\",\"P28562\",\"P30086\",\"P30153\",\"P30154\",\"P31946\",\"P35236\",\"P53041\",\"P53778\",\"P62714\",\"P62979\",\"P62987\",\"P67775\",\"Q05923\",\"Q13115\",\"Q13202\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q16690\",\"Q16828\",\"Q16829\",\"Q6TCH7\",\"Q7Z569\",\"Q8IVT5\",\"Q99956\",\"Q9BY84\",\"Q9Y6W6\"]", "gene_symbol": 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protein\",\"id\":\"P26927\"},{\"label\":\"Kunitz-type protease inhibitor 1\",\"id\":\"O43278\"},{\"label\":\"Kunitz-type protease inhibitor 2\",\"id\":\"O43291\"},{\"label\":\"Macrophage-stimulating protein receptor\",\"id\":\"Q04912\"},{\"label\":\"Serine protease hepsin\",\"id\":\"P05981\"}]", "uniprot_id": "[\"O43278\",\"O43291\",\"P05981\",\"P26927\",\"Q04912\"]", "gene_symbol": "[\"D3F15S2\",\"DNF15S2\",\"HAI1\",\"HAI2\",\"HGFL\",\"HPN\",\"KOP\",\"MST1\",\"MST1R\",\"PTK8\",\"RON\",\"SPINT1\",\"SPINT2\",\"TMPRSS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Fusion of the Influenza Virion to the Host Cell Endosome", "protein_name": "[{\"label\":\"Hemagglutinin\",\"id\":\"P03452\"},{\"label\":\"Matrix protein 1\",\"id\":\"P03485\"},{\"label\":\"Matrix protein 2\",\"id\":\"P06821\"},{\"label\":\"Neuraminidase\",\"id\":\"P03468\"},{\"label\":\"Nuclear export protein\",\"id\":\"P03508\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"}]", "uniprot_id": "[\"P03428\",\"P03431\",\"P03433\",\"P03452\",\"P03466\",\"P03468\",\"P03485\",\"P03508\",\"P06821\"]", "gene_symbol": "[\"HA\",\"M\",\"NA\",\"NP\",\"NS\",\"PA\",\"PB1\",\"PB2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mitotic Metaphase/Anaphase Transition", "protein_name": "[{\"label\":\"F-box only protein 5\",\"id\":\"Q9UKT4\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"}]", "uniprot_id": "[\"P53350\",\"Q9UKT4\"]", "gene_symbol": "[\"EMI1\",\"FBX5\",\"FBXO5\",\"PLK\",\"PLK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "protein_name": "[{\"label\":\"Arachidonate 5-lipoxygenase-activating protein\",\"id\":\"P20292\"},{\"label\":\"Cytochrome P450 4A11\",\"id\":\"Q02928\"},{\"label\":\"Cytochrome P450 4A22\",\"id\":\"Q5TCH4\"},{\"label\":\"Cytochrome P450 4B1\",\"id\":\"P13584\"},{\"label\":\"Cytochrome P450 4F11\",\"id\":\"Q9HBI6\"},{\"label\":\"Cytochrome P450 4F2\",\"id\":\"P78329\"},{\"label\":\"Cytochrome P450 4F3\",\"id\":\"Q08477\"},{\"label\":\"Cytochrome P450 4F8\",\"id\":\"P98187\"},{\"label\":\"Dipeptidase 1\",\"id\":\"P16444\"},{\"label\":\"Dipeptidase 2\",\"id\":\"Q9H4A9\"},{\"label\":\"Glutathione hydrolase 1 proenzyme\",\"id\":\"P19440\"},{\"label\":\"Glutathione hydrolase 5 proenzyme\",\"id\":\"P36269\"},{\"label\":\"Leukotriene A-4 hydrolase\",\"id\":\"P09960\"},{\"label\":\"Leukotriene C4 synthase\",\"id\":\"Q16873\"},{\"label\":\"MAP kinase-activated protein kinase 2\",\"id\":\"P49137\"},{\"label\":\"Multidrug resistance-associated protein 1\",\"id\":\"P33527\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"},{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX15\",\"id\":\"P16050\"},{\"label\":\"Prostaglandin reductase 1\",\"id\":\"Q14914\"},{\"label\":\"Ultra-long-chain fatty acid omega-hydroxylase\",\"id\":\"Q6NT55\"}]", "uniprot_id": "[\"P09917\",\"P09960\",\"P13584\",\"P16050\",\"P16444\",\"P19440\",\"P20292\",\"P33527\",\"P36269\",\"P49137\",\"P78329\",\"P98187\",\"Q02928\",\"Q08477\",\"Q14914\",\"Q16873\",\"Q5TCH4\",\"Q6NT55\",\"Q9H4A9\",\"Q9HBI6\"]", "gene_symbol": "[\"ABCC1\",\"ALOX15\",\"ALOX5\",\"ALOX5AP\",\"CYP4A11\",\"CYP4A2\",\"CYP4A22\",\"CYP4B1\",\"CYP4F11\",\"CYP4F2\",\"CYP4F22\",\"CYP4F3\",\"CYP4F8\",\"DPEP1\",\"DPEP2\",\"FLAP\",\"GGT\",\"GGT1\",\"GGT5\",\"GGTLA1\",\"LOG15\",\"LOG5\",\"LTA4\",\"LTA4H\",\"LTB4DH\",\"LTB4H\",\"LTC4S\",\"MAPKAPK2\",\"MDP\",\"MRP\",\"MRP1\",\"PTGR1\",\"RDP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-33 signaling", "protein_name": "[{\"label\":\"Interleukin-1 receptor-like 1\",\"id\":\"Q01638\"},{\"label\":\"Interleukin-33\",\"id\":\"O95760\"}]", "uniprot_id": "[\"O95760\",\"Q01638\"]", "gene_symbol": "[\"C9orf26\",\"DER4\",\"IL1F11\",\"IL1RL1\",\"IL33\",\"NFHEV\",\"ST2\",\"T1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ARL13B-mediated ciliary trafficking of INPP5E", "protein_name": "[{\"label\":\"ADP-ribosylation factor-like protein 13B\",\"id\":\"Q3SXY8\"},{\"label\":\"Phosphatidylinositol polyphosphate 5-phosphatase type IV\",\"id\":\"Q9NRR6\"},{\"label\":\"Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta\",\"id\":\"O43924\"}]", "uniprot_id": "[\"O43924\",\"Q3SXY8\",\"Q9NRR6\"]", "gene_symbol": "[\"ARL13B\",\"ARL2L1\",\"INPP5E\",\"PDE6D\",\"PDED\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Lysosomal oligosaccharide catabolism", "protein_name": "[{\"label\":\"Alpha-mannosidase 2C1\",\"id\":\"Q9NTJ4\"},{\"label\":\"Beta-mannosidase\",\"id\":\"O00462\"},{\"label\":\"Epididymis-specific alpha-mannosidase\",\"id\":\"Q9Y2E5\"},{\"label\":\"Lysosomal alpha-mannosidase\",\"id\":\"O00754\"}]", "uniprot_id": "[\"O00462\",\"O00754\",\"Q9NTJ4\",\"Q9Y2E5\"]", "gene_symbol": "[\"KIAA0935\",\"LAMAN\",\"MAN2B1\",\"MAN2B2\",\"MAN2C1\",\"MANA\",\"MANA1\",\"MANB\",\"MANB1\",\"MANBA\"]", "gtc_id": "[\"G00027MO\",\"G25577BM\",\"G28233ME\",\"G70323CJ\",\"G90333CG\"]" }, { "pathway_label": "Polo-like kinase mediated events", "protein_name": "[{\"label\":\"Centromere protein F\",\"id\":\"P49454\"},{\"label\":\"Forkhead box protein M1\",\"id\":\"Q08050\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"G2/mitotic-specific cyclin-B2\",\"id\":\"O95067\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"M-phase inducer phosphatase 1\",\"id\":\"P30304\"},{\"label\":\"M-phase inducer phosphatase 3\",\"id\":\"P30307\"},{\"label\":\"Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase\",\"id\":\"Q99640\"},{\"label\":\"Myb-related protein B\",\"id\":\"P10244\"},{\"label\":\"Protein lin-37 homolog\",\"id\":\"Q96GY3\"},{\"label\":\"Protein lin-52 homolog\",\"id\":\"Q52LA3\"},{\"label\":\"Protein lin-54 homolog\",\"id\":\"Q6MZP7\"},{\"label\":\"Protein lin-9 homolog\",\"id\":\"Q5TKA1\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"},{\"label\":\"Wee1-like protein kinase\",\"id\":\"P30291\"}]", "uniprot_id": "[\"O95067\",\"P10244\",\"P14635\",\"P30291\",\"P30304\",\"P30307\",\"P49454\",\"P53350\",\"Q08050\",\"Q09028\",\"Q09472\",\"Q52LA3\",\"Q5TKA1\",\"Q6MZP7\",\"Q96GY3\",\"Q99640\"]", "gene_symbol": "[\"BARA\",\"BMYB\",\"C14orf46\",\"CCNB\",\"CCNB1\",\"CCNB2\",\"CDC25A\",\"CDC25C\",\"CENPF\",\"CXCDC1\",\"EP300\",\"FKHL16\",\"FOXM1\",\"HFH11\",\"KIAA2037\",\"LIN37\",\"LIN52\",\"LIN54\",\"LIN9\",\"MPP2\",\"MYBL2\",\"MYT1\",\"P300\",\"PKMYT1\",\"PLK\",\"PLK1\",\"RBAP48\",\"RBBP4\",\"TGS\",\"WEE1\",\"WIN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CASP8 activity is inhibited", "protein_name": "[{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"FAS-associated death domain protein\",\"id\":\"Q13158\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 10\",\"id\":\"P50591\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 6\",\"id\":\"P48023\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10A\",\"id\":\"O00220\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10B\",\"id\":\"O14763\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 6\",\"id\":\"P25445\"},{\"label\":\"Tumor necrosis factor receptor type 1-associated DEATH domain protein\",\"id\":\"Q15628\"}]", "uniprot_id": "[\"O00220\",\"O14763\",\"P25445\",\"P48023\",\"P50591\",\"Q12933\",\"Q13158\",\"Q13546\",\"Q14790\",\"Q15628\"]", "gene_symbol": "[\"APO2\",\"APO2L\",\"APT1\",\"APT1LG1\",\"CASP8\",\"CD95L\",\"DR4\",\"DR5\",\"FADD\",\"FAS\",\"FAS1\",\"FASL\",\"FASLG\",\"KILLER\",\"MCH5\",\"MORT1\",\"RIP\",\"RIP1\",\"RIPK1\",\"TNFRSF10A\",\"TNFRSF10B\",\"TNFRSF6\",\"TNFSF10\",\"TNFSF6\",\"TRADD\",\"TRAF2\",\"TRAIL\",\"TRAILR1\",\"TRAILR2\",\"TRAP3\",\"TRICK2\",\"ZTNFR9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCB11 causes PFIC2 and BRIC2", "protein_name": "[{\"label\":\"Bile salt export pump\",\"id\":\"O95342\"}]", "uniprot_id": "[\"O95342\"]", "gene_symbol": "[\"ABCB11\",\"BSEP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of PIPs in the nucleus", "protein_name": "[{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha\",\"id\":\"P48426\"},{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 beta\",\"id\":\"P78356\"},{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma\",\"id\":\"Q8TBX8\"},{\"label\":\"Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase\",\"id\":\"Q86T03\"}]", "uniprot_id": "[\"P48426\",\"P78356\",\"Q86T03\",\"Q8TBX8\"]", "gene_symbol": "[\"C14orf9\",\"PI5P4KA\",\"PIP4K2A\",\"PIP4K2B\",\"PIP4K2C\",\"PIP4P1\",\"PIP5K2\",\"PIP5K2A\",\"PIP5K2B\",\"PIP5K2C\",\"TMEM55B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NFE2L2 regulating inflammation associated genes", "protein_name": "[{\"label\":\"C-C motif chemokine 2\",\"id\":\"P13500\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"},{\"label\":\"Transcription factor MafK\",\"id\":\"O60675\"}]", "uniprot_id": "[\"O60675\",\"P13500\",\"Q09472\",\"Q16236\",\"Q92793\"]", "gene_symbol": "[\"CBP\",\"CCL2\",\"CREBBP\",\"EP300\",\"MAFK\",\"MCP1\",\"NFE2L2\",\"NRF2\",\"P300\",\"SCYA2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FLT3 signaling by CBL mutants", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Fms-related tyrosine kinase 3 ligand\",\"id\":\"P49771\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"P0CG47\",\"P0CG48\",\"P22681\",\"P36888\",\"P49771\",\"P62979\",\"P62987\"]", "gene_symbol": "[\"CBL\",\"CBL2\",\"CD135\",\"FLK2\",\"FLT3\",\"FLT3LG\",\"RNF55\",\"RPS27A\",\"STK1\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mitochondrial Fatty Acid Beta-Oxidation", "protein_name": "[{\"label\":\"3-ketoacyl-CoA thiolase, mitochondrial\",\"id\":\"P42765\"},{\"label\":\"Acetyl-coenzyme A thioesterase\",\"id\":\"Q8WYK0\"},{\"label\":\"Acyl carrier protein, mitochondrial\",\"id\":\"O14561\"},{\"label\":\"Acyl-CoA dehydrogenase family member 10\",\"id\":\"Q6JQN1\"},{\"label\":\"Acyl-CoA dehydrogenase family member 11\",\"id\":\"Q709F0\"},{\"label\":\"Acyl-CoA-binding domain-containing protein 6\",\"id\":\"Q9BR61\"},{\"label\":\"Acyl-CoA-binding domain-containing protein 7\",\"id\":\"Q8N6N7\"},{\"label\":\"Acyl-CoA-binding protein\",\"id\":\"P07108\"},{\"label\":\"Acyl-coenzyme A thioesterase 11\",\"id\":\"Q8WXI4\"},{\"label\":\"Acyl-coenzyme A thioesterase 13\",\"id\":\"Q9NPJ3\"},{\"label\":\"Acyl-coenzyme A thioesterase 1\",\"id\":\"Q86TX2\"},{\"label\":\"Acyl-coenzyme A thioesterase 2, mitochondrial\",\"id\":\"P49753\"},{\"label\":\"Acyl-coenzyme A thioesterase 9, mitochondrial\",\"id\":\"Q9Y305\"},{\"label\":\"Acyl-coenzyme A thioesterase THEM4\",\"id\":\"Q5T1C6\"},{\"label\":\"Acyl-coenzyme A thioesterase THEM5\",\"id\":\"Q8N1Q8\"},{\"label\":\"Cytosolic acyl coenzyme A thioester hydrolase\",\"id\":\"O00154\"},{\"label\":\"Malonyl-CoA-acyl carrier protein transacylase, mitochondrial\",\"id\":\"Q8IVS2\"},{\"label\":\"Medium-chain acyl-CoA ligase ACSF2, mitochondrial\",\"id\":\"Q96CM8\"},{\"label\":\"Phosphatidylcholine transfer protein\",\"id\":\"Q9UKL6\"},{\"label\":\"Putative cytosolic acyl coenzyme A thioester hydrolase-like\",\"id\":\"Q6ZUV0\"}]", "uniprot_id": "[\"O00154\",\"O14561\",\"P07108\",\"P42765\",\"P49753\",\"Q5T1C6\",\"Q6JQN1\",\"Q6ZUV0\",\"Q709F0\",\"Q86TX2\",\"Q8IVS2\",\"Q8N1Q8\",\"Q8N6N7\",\"Q8WXI4\",\"Q8WYK0\",\"Q96CM8\",\"Q9BR61\",\"Q9NPJ3\",\"Q9UKL6\",\"Q9Y305\"]", "gene_symbol": "[\"ACAA2\",\"ACAD10\",\"ACAD11\",\"ACBD6\",\"ACBD7\",\"ACOT1\",\"ACOT11\",\"ACOT12\",\"ACOT13\",\"ACOT15\",\"ACOT2\",\"ACOT7\",\"ACOT7L\",\"ACOT9\",\"ACSF2\",\"BACH\",\"BACHL\",\"BFIT\",\"CACH\",\"CACH1\",\"CTE1\",\"CTMP\",\"DBI\",\"KIAA0707\",\"MCAT\",\"MT\",\"NDUFAB1\",\"PCTP\",\"PTE2\",\"PTE2A\",\"STARD15\",\"STARD2\",\"THEA\",\"THEM2\",\"THEM4\",\"THEM5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Early Phase of HIV Life Cycle", "protein_name": "[{\"label\":\"DNA ligase 1\",\"id\":\"P18858\"},{\"label\":\"Flap endonuclease 1\",\"id\":\"P39748\"},{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Protein Rev\",\"id\":\"P04618\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"P04585\",\"P04591\",\"P04618\",\"P05919\",\"P18858\",\"P39748\",\"P62937\",\"P69723\",\"P69726\"]", "gene_symbol": "[\"CYPA\",\"FEN1\",\"LIG1\",\"PPIA\",\"RAD2\",\"gag\",\"gag-pol\",\"rev\",\"vif\",\"vpr\",\"vpu\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "protein_name": "[{\"label\":\"Androgen 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"gtc_id": "[\"\"]" }, { "pathway_label": "Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "protein_name": "[{\"label\":\"Histone-lysine N-methyltransferase 2C\",\"id\":\"Q8NEZ4\"},{\"label\":\"Histone-lysine N-methyltransferase 2D\",\"id\":\"O14686\"},{\"label\":\"Lysine-specific demethylase 6A\",\"id\":\"O15550\"},{\"label\":\"Nuclear receptor coactivator 6\",\"id\":\"Q14686\"},{\"label\":\"PAX-interacting protein 1\",\"id\":\"Q6ZW49\"},{\"label\":\"PAXIP1-associated glutamate-rich protein 1\",\"id\":\"Q9BTK6\"},{\"label\":\"Protein dpy-30 homolog\",\"id\":\"Q9C005\"},{\"label\":\"Retinoblastoma-binding protein 5\",\"id\":\"Q15291\"},{\"label\":\"Set1/Ash2 histone methyltransferase complex subunit ASH2\",\"id\":\"Q9UBL3\"},{\"label\":\"WD repeat-containing protein 5\",\"id\":\"P61964\"}]", "uniprot_id": "[\"O14686\",\"O15550\",\"P61964\",\"Q14686\",\"Q15291\",\"Q6ZW49\",\"Q8NEZ4\",\"Q9BTK6\",\"Q9C005\",\"Q9UBL3\"]", "gene_symbol": 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receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Fibroblast growth factor receptor substrate 3\",\"id\":\"O43559\"},{\"label\":\"Flotillin-2\",\"id\":\"Q14254\"},{\"label\":\"Girdin\",\"id\":\"Q3V6T2\"},{\"label\":\"Growth factor receptor-bound protein 7\",\"id\":\"Q14451\"},{\"label\":\"Inner nuclear membrane protein Man1\",\"id\":\"Q9Y2U8\"},{\"label\":\"Kinase D-interacting substrate of 220 kDa\",\"id\":\"Q9ULH0\"},{\"label\":\"Kinesin-like protein KIF14\",\"id\":\"Q15058\"},{\"label\":\"Mucin-13\",\"id\":\"Q9H3R2\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Plakophilin-4\",\"id\":\"Q99569\"},{\"label\":\"Pleckstrin homology domain-containing family G member 5\",\"id\":\"O94827\"},{\"label\":\"Plexin-A1\",\"id\":\"Q9UIW2\"},{\"label\":\"Protein FAM135A\",\"id\":\"Q9P2D6\"},{\"label\":\"Protein FAM83B\",\"id\":\"Q5T0W9\"},{\"label\":\"RNA-binding motif protein, X chromosome\",\"id\":\"P38159\"},{\"label\":\"Ras GTPase-activating protein nGAP\",\"id\":\"Q9UJF2\"},{\"label\":\"Ras-related protein R-Ras2\",\"id\":\"P62070\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho GTPase-activating protein 5\",\"id\":\"Q13017\"},{\"label\":\"Rho-related GTP-binding protein Rho6\",\"id\":\"Q92730\"},{\"label\":\"Stathmin-2\",\"id\":\"Q93045\"},{\"label\":\"Stress-induced-phosphoprotein 1\",\"id\":\"P31948\"},{\"label\":\"Thioredoxin-like protein 1\",\"id\":\"O43396\"},{\"label\":\"Transferrin receptor protein 1\",\"id\":\"P02786\"},{\"label\":\"Transmembrane protein 59\",\"id\":\"Q9BXS4\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 13\",\"id\":\"Q12923\"},{\"label\":\"UBX domain-containing protein 11\",\"id\":\"Q5T124\"},{\"label\":\"Vang-like protein 1\",\"id\":\"Q8TAA9\"},{\"label\":\"Vang-like protein 2\",\"id\":\"Q9ULK5\"},{\"label\":\"tRNA (34-2'-O)-methyltransferase regulator WDR6\",\"id\":\"Q9NNW5\"}]", "uniprot_id": "[\"O00459\",\"O43396\",\"O43559\",\"O75976\",\"O94827\",\"P02786\",\"P15924\",\"P27986\",\"P29317\",\"P31948\",\"P38159\",\"P51648\",\"P62070\",\"Q03001\",\"Q03135\",\"Q12923\",\"Q13017\",\"Q14254\",\"Q14451\",\"Q15058\",\"Q3V6T2\",\"Q5T0W9\",\"Q5T124\",\"Q8TAA9\",\"Q8TDM6\",\"Q8WU20\",\"Q8WUY9\",\"Q92730\",\"Q93045\",\"Q96J88\",\"Q99569\",\"Q9BXS4\",\"Q9H3R2\",\"Q9NNW5\",\"Q9NRY4\",\"Q9P2D6\",\"Q9UIW2\",\"Q9UJF2\",\"Q9ULH0\",\"Q9ULK5\",\"Q9UPS8\",\"Q9Y2U8\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "OADH complex synthesizes glutaryl-CoA from 2-OA", "protein_name": "[{\"label\":\"2-oxoadipate dehydrogenase complex component E1\",\"id\":\"Q96HY7\"},{\"label\":\"Dihydrolipoyl dehydrogenase, mitochondrial\",\"id\":\"P09622\"},{\"label\":\"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial\",\"id\":\"P36957\"}]", "uniprot_id": "[\"P09622\",\"P36957\",\"Q96HY7\"]", "gene_symbol": "[\"DHTKD1\",\"DLD\",\"DLST\",\"DLTS\",\"GCSL\",\"KIAA1630\",\"LAD\",\"PHE3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "The activation of arylsulfatases", "protein_name": "[{\"label\":\"Arylsulfatase A\",\"id\":\"P15289\"},{\"label\":\"Arylsulfatase B\",\"id\":\"P15848\"},{\"label\":\"Arylsulfatase D\",\"id\":\"P51689\"},{\"label\":\"Arylsulfatase F\",\"id\":\"P54793\"},{\"label\":\"Arylsulfatase G\",\"id\":\"Q96EG1\"},{\"label\":\"Arylsulfatase H\",\"id\":\"Q5FYA8\"},{\"label\":\"Arylsulfatase I\",\"id\":\"Q5FYB1\"},{\"label\":\"Arylsulfatase J\",\"id\":\"Q5FYB0\"},{\"label\":\"Arylsulfatase K\",\"id\":\"Q6UWY0\"},{\"label\":\"Arylsulfatase L\",\"id\":\"P51690\"},{\"label\":\"Formylglycine-generating enzyme\",\"id\":\"Q8NBK3\"},{\"label\":\"Inactive C-alpha-formylglycine-generating enzyme 2\",\"id\":\"Q8NBJ7\"},{\"label\":\"Steryl-sulfatase\",\"id\":\"P08842\"}]", "uniprot_id": "[\"P08842\",\"P15289\",\"P15848\",\"P51689\",\"P51690\",\"P54793\",\"Q5FYA8\",\"Q5FYB0\",\"Q5FYB1\",\"Q6UWY0\",\"Q8NBJ7\",\"Q8NBK3\",\"Q96EG1\"]", "gene_symbol": "[\"ARSA\",\"ARSB\",\"ARSC1\",\"ARSD\",\"ARSE\",\"ARSF\",\"ARSG\",\"ARSH\",\"ARSI\",\"ARSJ\",\"ARSK\",\"ARSL\",\"KIAA1001\",\"STS\",\"SUMF1\",\"SUMF2\",\"TSULF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "linifanib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Platelet homeostasis", "protein_name": "[{\"label\":\"P2X purinoceptor 1\",\"id\":\"P51575\"},{\"label\":\"P2X purinoceptor 2\",\"id\":\"Q9UBL9\"},{\"label\":\"P2X purinoceptor 3\",\"id\":\"P56373\"},{\"label\":\"P2X purinoceptor 4\",\"id\":\"Q99571\"},{\"label\":\"P2X purinoceptor 5\",\"id\":\"Q93086\"},{\"label\":\"P2X purinoceptor 6\",\"id\":\"O15547\"},{\"label\":\"P2X purinoceptor 7\",\"id\":\"Q99572\"},{\"label\":\"Platelet-activating factor acetylhydrolase 2, cytoplasmic\",\"id\":\"Q99487\"}]", "uniprot_id": "[\"O15547\",\"P51575\",\"P56373\",\"Q93086\",\"Q99487\",\"Q99571\",\"Q99572\",\"Q9UBL9\"]", "gene_symbol": "[\"P2RX1\",\"P2RX2\",\"P2RX3\",\"P2RX4\",\"P2RX5\",\"P2RX6\",\"P2RX7\",\"P2RXL1\",\"P2X1\",\"P2X2\",\"P2X5\",\"P2X5FL\",\"P2X6\",\"PAFAH2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FLT3 signaling through SRC family kinases", "protein_name": "[{\"label\":\"Fms-related tyrosine kinase 3 ligand\",\"id\":\"P49771\"},{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase HCK\",\"id\":\"P08631\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein kinase SYK\",\"id\":\"P43405\"}]", "uniprot_id": "[\"P06239\",\"P06241\",\"P08631\",\"P36888\",\"P43405\",\"P49771\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"FLT3LG\",\"FYN\",\"HCK\",\"LCK\",\"STK1\",\"SYK\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective RFT1 causes CDG-1n", "protein_name": "[{\"label\":\"Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1\",\"id\":\"Q96AA3\"}]", "uniprot_id": "[\"Q96AA3\"]", "gene_symbol": "[\"RFT1\"]", "gtc_id": "[\"G59406KS\"]" }, { "pathway_label": "Activation, translocation and oligomerization of BAX", "protein_name": "[{\"label\":\"Apoptosis regulator BAX\",\"id\":\"Q07812\"},{\"label\":\"BH3-interacting domain death agonist\",\"id\":\"P55957\"}]", "uniprot_id": "[\"P55957\",\"Q07812\"]", "gene_symbol": "[\"BAX\",\"BCL2L4\",\"BID\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective DNA double strand break response due to BARD1 loss of function", "protein_name": "[{\"label\":\"BRCA1-associated RING domain protein 1\",\"id\":\"Q99728\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"}]", "uniprot_id": "[\"P38398\",\"Q99728\"]", "gene_symbol": "[\"BARD1\",\"BRCA1\",\"RNF53\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Elastic fibre formation", "protein_name": "[{\"label\":\"Elastin\",\"id\":\"P15502\"},{\"label\":\"Fibrillin-1\",\"id\":\"P35555\"},{\"label\":\"Fibrillin-2\",\"id\":\"P35556\"},{\"label\":\"Fibrillin-3\",\"id\":\"Q75N90\"},{\"label\":\"Fibulin-5\",\"id\":\"Q9UBX5\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Integrin alpha-5\",\"id\":\"P08648\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Integrin beta-6\",\"id\":\"P18564\"},{\"label\":\"Lysyl oxidase homolog 1\",\"id\":\"Q08397\"},{\"label\":\"Lysyl oxidase homolog 2\",\"id\":\"Q9Y4K0\"},{\"label\":\"Lysyl oxidase homolog 3\",\"id\":\"P58215\"},{\"label\":\"Lysyl oxidase homolog 4\",\"id\":\"Q96JB6\"},{\"label\":\"Microfibrillar-associated protein 2\",\"id\":\"P55001\"},{\"label\":\"Microfibrillar-associated protein 5\",\"id\":\"Q13361\"},{\"label\":\"Protein-lysine 6-oxidase\",\"id\":\"P28300\"}]", "uniprot_id": "[\"P05106\",\"P05556\",\"P06756\",\"P08648\",\"P09958\",\"P15502\",\"P18564\",\"P28300\",\"P35555\",\"P35556\",\"P55001\",\"P58215\",\"Q08397\",\"Q13361\",\"Q75N90\",\"Q96JB6\",\"Q9UBX5\",\"Q9Y4K0\"]", "gene_symbol": "[\"DANCE\",\"ELN\",\"FBLN5\",\"FBN\",\"FBN1\",\"FBN2\",\"FBN3\",\"FNRA\",\"FNRB\",\"FUR\",\"FURIN\",\"GP3A\",\"ITGA5\",\"ITGAV\",\"ITGB1\",\"ITGB3\",\"ITGB6\",\"KIAA1776\",\"LOX\",\"LOXC\",\"LOXL\",\"LOXL1\",\"LOXL2\",\"LOXL3\",\"LOXL4\",\"MAGP1\",\"MAGP2\",\"MDF2\",\"MFAP2\",\"MFAP5\",\"MSK12\",\"MSK8\",\"PACE\",\"PCSK3\",\"VNRA\",\"VTNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Multifunctional anion exchangers", "protein_name": "[{\"label\":\"Anion exchange transporter\",\"id\":\"Q8TE54\"},{\"label\":\"Chloride anion exchanger\",\"id\":\"P40879\"},{\"label\":\"Pendrin\",\"id\":\"O43511\"},{\"label\":\"Sodium-coupled monocarboxylate transporter 2\",\"id\":\"Q1EHB4\"},{\"label\":\"Sodium-independent sulfate anion transporter\",\"id\":\"Q86WA9\"},{\"label\":\"Solute carrier family 26 member 6\",\"id\":\"Q9BXS9\"},{\"label\":\"Solute carrier family 26 member 9\",\"id\":\"Q7LBE3\"},{\"label\":\"Sulfate anion transporter 1\",\"id\":\"Q9H2B4\"},{\"label\":\"Sulfate transporter\",\"id\":\"P50443\"}]", "uniprot_id": "[\"O43511\",\"P40879\",\"P50443\",\"Q1EHB4\",\"Q7LBE3\",\"Q86WA9\",\"Q8TE54\",\"Q9BXS9\",\"Q9H2B4\"]", "gene_symbol": "[\"DRA\",\"DTD\",\"DTDST\",\"PDS\",\"SAT1\",\"SLC26A1\",\"SLC26A11\",\"SLC26A2\",\"SLC26A3\",\"SLC26A4\",\"SLC26A6\",\"SLC26A7\",\"SLC26A9\",\"SLC5A12\",\"SMCT2\",\"SUT2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Toxicity of botulinum toxin type A (botA)", "protein_name": "[{\"label\":\"Botulinum neurotoxin type A\",\"id\":\"P0DPI0\"},{\"label\":\"HA-17\",\"id\":\"Q45878\"},{\"label\":\"HA-33 protein\",\"id\":\"Q57230\"},{\"label\":\"Ha70 protein\",\"id\":\"Q45877\"},{\"label\":\"NTNHA\",\"id\":\"Q9LBS8\"},{\"label\":\"Synaptic vesicle glycoprotein 2A\",\"id\":\"Q7L0J3\"},{\"label\":\"Synaptic vesicle glycoprotein 2B\",\"id\":\"Q7L1I2\"},{\"label\":\"Synaptic vesicle glycoprotein 2C\",\"id\":\"Q496J9\"},{\"label\":\"Synaptosomal-associated protein 25\",\"id\":\"P60880\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "protein_name": "[{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Mast/stem cell growth factor receptor Kit\",\"id\":\"P10721\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase Yes\",\"id\":\"P07947\"}]", "uniprot_id": "[\"O00459\",\"O60674\",\"P01111\",\"P01112\",\"P06239\",\"P06241\",\"P07947\",\"P07948\",\"P10721\",\"P27986\",\"P40763\",\"P42224\",\"P42229\",\"P42336\",\"P51692\",\"Q07889\",\"Q92569\"]", "gene_symbol": "[\"APRF\",\"FYN\",\"GRB1\",\"HRAS\",\"HRAS1\",\"JAK2\",\"JTK8\",\"KIT\",\"LCK\",\"LYN\",\"NRAS\",\"PIK3CA\",\"PIK3R1\",\"PIK3R2\",\"PIK3R3\",\"SCFR\",\"SOS1\",\"STAT1\",\"STAT3\",\"STAT5\",\"STAT5A\",\"STAT5B\",\"YES\",\"YES1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TWIK related potassium channel (TREK)", "protein_name": "[{\"label\":\"Potassium channel subfamily K member 10\",\"id\":\"P57789\"},{\"label\":\"Potassium channel subfamily K member 2\",\"id\":\"O95069\"},{\"label\":\"Potassium channel subfamily K member 4\",\"id\":\"Q9NYG8\"}]", "uniprot_id": "[\"O95069\",\"P57789\",\"Q9NYG8\"]", "gene_symbol": "[\"KCNK10\",\"KCNK2\",\"KCNK4\",\"TRAAK\",\"TREK\",\"TREK1\",\"TREK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Inositol transporters", "protein_name": "[{\"label\":\"Proton myo-inositol cotransporter\",\"id\":\"Q96QE2\"},{\"label\":\"Sodium/myo-inositol cotransporter 2\",\"id\":\"Q8WWX8\"},{\"label\":\"Sodium/myo-inositol cotransporter\",\"id\":\"P53794\"}]", "uniprot_id": "[\"P53794\",\"Q8WWX8\",\"Q96QE2\"]", "gene_symbol": "[\"KST1\",\"SLC2A13\",\"SLC5A11\",\"SLC5A3\",\"SLGTX\",\"SMIT2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Adrenaline signalling through Alpha-2 adrenergic receptor", "protein_name": "[{\"label\":\"Alpha-2A adrenergic receptor\",\"id\":\"P08913\"},{\"label\":\"Alpha-2B adrenergic receptor\",\"id\":\"P18089\"},{\"label\":\"Alpha-2C adrenergic receptor\",\"id\":\"P18825\"}]", "uniprot_id": "[\"P08913\",\"P18089\",\"P18825\"]", "gene_symbol": "[\"ADRA2A\",\"ADRA2B\",\"ADRA2C\",\"ADRA2L1\",\"ADRA2L2\",\"ADRA2R\",\"ADRA2RL1\",\"ADRA2RL2\",\"ADRAR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PTK6 promotes HIF1A stabilization", "protein_name": "[{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Hypoxia-inducible factor 1-alpha\",\"id\":\"Q16665\"},{\"label\":\"Leucine-rich repeat serine/threonine-protein kinase 2\",\"id\":\"Q5S007\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Protein-tyrosine kinase 6\",\"id\":\"Q13882\"},{\"label\":\"Transmembrane glycoprotein NMB\",\"id\":\"Q14956\"}]", "uniprot_id": "[\"P00533\",\"Q13882\",\"Q14956\",\"Q16665\",\"Q5S007\",\"Q99075\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of IPs in the ER lumen", "protein_name": "[{\"label\":\"Multiple inositol polyphosphate phosphatase 1\",\"id\":\"Q9UNW1\"}]", "uniprot_id": "[\"Q9UNW1\"]", "gene_symbol": "[\"MINPP1\",\"MIPP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "B-WICH complex positively regulates rRNA expression", "protein_name": "[{\"label\":\"Actin, cytoplasmic 1\",\"id\":\"P60709\"},{\"label\":\"DNA excision repair protein ERCC-6\",\"id\":\"Q03468\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA12\",\"id\":\"Q9P1U0\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA1\",\"id\":\"O95602\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA2\",\"id\":\"Q9H9Y6\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA34\",\"id\":\"O15446\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA43\",\"id\":\"Q3B726\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA49\",\"id\":\"Q9GZS1\"},{\"label\":\"DNA-directed RNA polymerases I and 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective NEU1 causes sialidosis", "protein_name": "[{\"label\":\"Beta-galactosidase\",\"id\":\"P16278\"},{\"label\":\"Lysosomal protective protein\",\"id\":\"P10619\"},{\"label\":\"Sialidase-1\",\"id\":\"Q99519\"}]", "uniprot_id": "[\"P10619\",\"P16278\",\"Q99519\"]", "gene_symbol": "[\"CTSA\",\"ELNR1\",\"GLB1\",\"NANH\",\"NEU1\",\"PPGB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mitochondrial transcription initiation", "protein_name": "[{\"label\":\"DNA-directed RNA polymerase, mitochondrial\",\"id\":\"O00411\"},{\"label\":\"Dimethyladenosine transferase 2, mitochondrial\",\"id\":\"Q9H5Q4\"},{\"label\":\"Transcription factor A, mitochondrial\",\"id\":\"Q00059\"}]", "uniprot_id": "[\"O00411\",\"Q00059\",\"Q9H5Q4\"]", "gene_symbol": "[\"NS5ATP5\",\"POLRMT\",\"TCF6\",\"TCF6L2\",\"TFAM\",\"TFB2M\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ATP sensitive Potassium channels", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 8\",\"id\":\"Q09428\"},{\"label\":\"ATP-binding cassette sub-family C member 9\",\"id\":\"O60706\"},{\"label\":\"ATP-sensitive inward rectifier potassium channel 11\",\"id\":\"Q14654\"},{\"label\":\"ATP-sensitive inward rectifier potassium channel 8\",\"id\":\"Q15842\"}]", "uniprot_id": "[\"O60706\",\"Q09428\",\"Q14654\",\"Q15842\"]", "gene_symbol": "[\"ABCC8\",\"ABCC9\",\"HRINS\",\"KCNJ11\",\"KCNJ8\",\"SUR\",\"SUR1\",\"SUR2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "C6 deamination of adenosine", "protein_name": "[{\"label\":\"Double-stranded RNA-specific adenosine deaminase\",\"id\":\"P55265\"},{\"label\":\"Double-stranded RNA-specific editase 1\",\"id\":\"P78563\"}]", "uniprot_id": "[\"P55265\",\"P78563\"]", "gene_symbol": "[\"ADAR\",\"ADAR1\",\"ADAR2\",\"ADARB1\",\"DRADA2\",\"DSRAD\",\"G1P1\",\"IFI4\",\"RED1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Resistance of ERBB2 KD mutants to trastuzumab", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P04626\",\"P07900\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Inactivation of CSF3 (G-CSF) signaling", "protein_name": "[{\"label\":\"Cullin-5\",\"id\":\"Q93034\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"Granulocyte colony-stimulating factor receptor\",\"id\":\"Q99062\"},{\"label\":\"Granulocyte colony-stimulating factor\",\"id\":\"P09919\"},{\"label\":\"Non-receptor tyrosine-protein kinase 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1\",\"id\":\"P18031\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"},{\"label\":\"Ubl carboxyl-terminal hydrolase 18\",\"id\":\"Q9UMW8\"}]", "uniprot_id": "[\"O14543\",\"O15524\",\"P01562\",\"P01563\",\"P01566\",\"P01567\",\"P01568\",\"P01569\",\"P01570\",\"P01571\",\"P01574\",\"P05013\",\"P05014\",\"P05015\",\"P17181\",\"P18031\",\"P23458\",\"P29350\",\"P29597\",\"P32881\",\"P52630\",\"Q06124\",\"Q9UMW8\"]", "gene_symbol": "[\"CIS3\",\"HCP\",\"IFB\",\"IFNA1\",\"IFNA10\",\"IFNA13\",\"IFNA14\",\"IFNA16\",\"IFNA17\",\"IFNA2\",\"IFNA21\",\"IFNA2A\",\"IFNA2B\",\"IFNA2C\",\"IFNA4\",\"IFNA5\",\"IFNA6\",\"IFNA7\",\"IFNA8\",\"IFNAR\",\"IFNAR1\",\"IFNB\",\"IFNB1\",\"ISG43\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"PTP1B\",\"PTP1C\",\"PTP2C\",\"PTPN1\",\"PTPN11\",\"PTPN6\",\"SHPTP2\",\"SOCS1\",\"SOCS3\",\"SSI1\",\"SSI3\",\"STAT2\",\"TIP3\",\"TYK2\",\"USP18\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of APC/C activators between G1/S and early anaphase", 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homolog\",\"id\":\"P30260\"},{\"label\":\"Cyclin-A1\",\"id\":\"P78396\"},{\"label\":\"Cyclin-A2\",\"id\":\"P20248\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"F-box only protein 5\",\"id\":\"Q9UKT4\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"}]", "uniprot_id": "[\"O00762\",\"P06493\",\"P14635\",\"P20248\",\"P24941\",\"P30260\",\"P51668\",\"P51965\",\"P60006\",\"P78396\",\"Q12834\",\"Q13042\",\"Q16763\",\"Q8NHZ8\",\"Q96DE5\",\"Q9H1A4\",\"Q9NYG5\",\"Q9UJX2\",\"Q9UJX3\",\"Q9UJX4\",\"Q9UJX5\",\"Q9UJX6\",\"Q9UKT4\",\"Q9UM11\",\"Q9UM13\"]", "gene_symbol": "[\"ANAPC1\",\"ANAPC10\",\"ANAPC11\",\"ANAPC12\",\"ANAPC15\",\"ANAPC16\",\"ANAPC2\",\"ANAPC3\",\"ANAPC4\",\"ANAPC5\",\"ANAPC6\",\"ANAPC7\",\"ANAPC8\",\"APC10\",\"APC2\",\"APC4\",\"APC5\",\"APC7\",\"C10orf104\",\"C11orf51\",\"C9orf17\",\"CCN1\",\"CCNA\",\"CCNA1\",\"CCNA2\",\"CCNB\",\"CCNB1\",\"CDC16\",\"CDC2\",\"CDC20\",\"CDC23\",\"CDC26\",\"CDC27\",\"CDC28A\",\"CDH1\",\"CDK1\",\"CDK2\",\"CDKN1\",\"CDKN2\",\"CENP-27\",\"D0S1430E\",\"D17S978E\",\"E2EPF\",\"EMI1\",\"FBX5\",\"FBXO5\",\"FYR\",\"FZR\",\"FZR1\",\"KIAA1242\",\"KIAA1406\",\"P34CDC2\",\"SFT\",\"TSG24\",\"UBC5A\",\"UBCH10\",\"UBCH5\",\"UBCH5A\",\"UBCH6\",\"UBE2C\",\"UBE2D1\",\"UBE2E1\",\"UBE2S\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of UDP-N-acetyl-glucosamine", "protein_name": "[{\"label\":\"Glucosamine 6-phosphate N-acetyltransferase\",\"id\":\"Q96EK6\"},{\"label\":\"Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1\",\"id\":\"Q06210\"},{\"label\":\"Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2\",\"id\":\"O94808\"},{\"label\":\"N-acetyl-D-glucosamine kinase\",\"id\":\"Q9UJ70\"},{\"label\":\"N-acetylglucosamine-6-phosphate deacetylase\",\"id\":\"Q9Y303\"},{\"label\":\"N-acylglucosamine 2-epimerase\",\"id\":\"P51606\"},{\"label\":\"Phosphoacetylglucosamine mutase\",\"id\":\"O95394\"},{\"label\":\"UDP-N-acetylhexosamine pyrophosphorylase\",\"id\":\"Q16222\"}]", "uniprot_id": "[\"O94808\",\"O95394\",\"P51606\",\"Q06210\",\"Q16222\",\"Q96EK6\",\"Q9UJ70\",\"Q9Y303\"]", "gene_symbol": "[\"AGM1\",\"AMDHD2\",\"GFAT\",\"GFPT\",\"GFPT1\",\"GFPT2\",\"GNA1\",\"GNPNAT1\",\"NAGK\",\"PGM3\",\"RENBP\",\"SPAG2\",\"UAP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Fructose biosynthesis", "protein_name": "[{\"label\":\"Aldo-keto reductase family 1 member B1\",\"id\":\"P15121\"},{\"label\":\"Sorbitol dehydrogenase\",\"id\":\"Q00796\"}]", "uniprot_id": "[\"P15121\",\"Q00796\"]", "gene_symbol": "[\"AKR1B1\",\"ALDR1\",\"ALR2\",\"SORD\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "RHO GTPases activate KTN1", "protein_name": "[{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Kinectin\",\"id\":\"Q86UP2\"},{\"label\":\"Kinesin heavy chain isoform 5A\",\"id\":\"Q12840\"},{\"label\":\"Kinesin light chain 1\",\"id\":\"Q07866\"},{\"label\":\"Kinesin light chain 2\",\"id\":\"Q9H0B6\"},{\"label\":\"Kinesin light chain 3\",\"id\":\"Q6P597\"},{\"label\":\"Kinesin light chain 4\",\"id\":\"Q9NSK0\"},{\"label\":\"Kinesin-1 heavy chain\",\"id\":\"P33176\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Rho-related GTP-binding protein RhoG\",\"id\":\"P84095\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"}]", "uniprot_id": "[\"P33176\",\"P60953\",\"P61586\",\"P63000\",\"P84095\",\"Q07866\",\"Q12840\",\"Q6P597\",\"Q86UP2\",\"Q9H0B6\",\"Q9NSK0\"]", "gene_symbol": 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2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 4\",\"id\":\"P22455\"}]", "uniprot_id": "[\"O43320\",\"O76093\",\"O95750\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P22455\",\"P31371\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF16\",\"FGF18\",\"FGF19\",\"FGF2\",\"FGF20\",\"FGF23\",\"FGF4\",\"FGF6\",\"FGF9\",\"FGFA\",\"FGFB\",\"FGFR4\",\"HST\",\"HST2\",\"HSTF1\",\"HSTF2\",\"HYPF\",\"JTK2\",\"KS3\",\"TKF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation", "protein_name": "[{\"label\":\"Homeobox protein NANOG\",\"id\":\"Q9H9S0\"},{\"label\":\"POU domain, class 5, transcription factor 1\",\"id\":\"Q01860\"},{\"label\":\"Transcription factor SOX-2\",\"id\":\"P48431\"}]", "uniprot_id": "[\"P48431\",\"Q01860\",\"Q9H9S0\"]", "gene_symbol": "[\"NANOG\",\"OCT3\",\"OCT4\",\"OTF3\",\"POU5F1\",\"SOX2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Phenylalanine metabolism", "protein_name": "[{\"label\":\"Dihydropteridine reductase\",\"id\":\"P09417\"},{\"label\":\"Isoaspartyl peptidase/L-asparaginase\",\"id\":\"Q7L266\"},{\"label\":\"Kynurenine--oxoglutarate transaminase 1\",\"id\":\"Q16773\"},{\"label\":\"L-amino-acid oxidase\",\"id\":\"Q96RQ9\"},{\"label\":\"Phenylalanine-4-hydroxylase\",\"id\":\"P00439\"},{\"label\":\"Pterin-4-alpha-carbinolamine dehydratase\",\"id\":\"P61457\"}]", "uniprot_id": "[\"P00439\",\"P09417\",\"P61457\",\"Q16773\",\"Q7L266\",\"Q96RQ9\"]", "gene_symbol": "[\"ALP\",\"ASRGL1\",\"CCBL1\",\"CRASH\",\"DCOH\",\"DHPR\",\"FIG1\",\"IL4I1\",\"KYAT1\",\"PAH\",\"PCBD\",\"PCBD1\",\"QDPR\",\"SDR33C1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TGF-beta receptor signaling activates SMADs", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Integrin alpha-8\",\"id\":\"P53708\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Integrin beta-5\",\"id\":\"P18084\"},{\"label\":\"Integrin beta-6\",\"id\":\"P18564\"},{\"label\":\"Integrin beta-8\",\"id\":\"P26012\"},{\"label\":\"Latent-transforming growth factor beta-binding protein 1\",\"id\":\"Q14766\"},{\"label\":\"Latent-transforming growth factor beta-binding protein 2\",\"id\":\"Q14767\"},{\"label\":\"Latent-transforming growth factor beta-binding protein 3\",\"id\":\"Q9NS15\"},{\"label\":\"Latent-transforming growth factor beta-binding protein 4\",\"id\":\"Q8N2S1\"},{\"label\":\"Mothers against decapentaplegic homolog 2\",\"id\":\"Q15796\"},{\"label\":\"Mothers against decapentaplegic homolog 3\",\"id\":\"P84022\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"NEDD8-conjugating enzyme Ubc12\",\"id\":\"P61081\"},{\"label\":\"NEDD8\",\"id\":\"Q15843\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase FKBP1A\",\"id\":\"P62942\"},{\"label\":\"TGF-beta receptor type-1\",\"id\":\"P36897\"},{\"label\":\"TGF-beta receptor type-2\",\"id\":\"P37173\"},{\"label\":\"Transforming growth factor beta receptor type 3\",\"id\":\"Q03167\"},{\"label\":\"Transforming growth factor beta-1 proprotein\",\"id\":\"P01137\"},{\"label\":\"Transforming growth factor beta-2 proprotein\",\"id\":\"P61812\"},{\"label\":\"Transforming growth factor beta-3 proprotein\",\"id\":\"P10600\"}]", "uniprot_id": "[\"P01137\",\"P05106\",\"P05556\",\"P06756\",\"P09958\",\"P10600\",\"P18084\",\"P18564\",\"P22681\",\"P26012\",\"P36897\",\"P37173\",\"P53708\",\"P61081\",\"P61812\",\"P62942\",\"P84022\",\"Q03167\",\"Q13485\",\"Q14766\",\"Q14767\",\"Q15796\",\"Q15843\",\"Q8N2S1\",\"Q9NS15\"]", "gene_symbol": 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mono-ADP-ribosyltransferase PARP14\",\"id\":\"Q460N5\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP16\",\"id\":\"Q8N5Y8\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP4\",\"id\":\"Q9UKK3\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP6\",\"id\":\"Q2NL67\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP8\",\"id\":\"Q8N3A8\"},{\"label\":\"Protein mono-ADP-ribosyltransferase PARP9\",\"id\":\"Q8IXQ6\"},{\"label\":\"SRSF protein kinase 1\",\"id\":\"Q96SB4\"},{\"label\":\"SRSF protein kinase 2\",\"id\":\"P78362\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"}]", "uniprot_id": "[\"P0DTC9\",\"P48729\",\"P49840\",\"P49841\",\"P63165\",\"P63279\",\"P78362\",\"Q2NL67\",\"Q460N5\",\"Q53GL7\",\"Q8IXQ6\",\"Q8N3A8\",\"Q8N5Y8\",\"Q96SB4\",\"Q99873\",\"Q9UKK3\"]", "gene_symbol": 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"[\"CCDC88C\",\"CXXC4\",\"DAPLE\",\"DVL1\",\"DVL2\",\"DVL3\",\"IDAX\",\"KIAA0208\",\"KIAA1509\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FOXO-mediated transcription of cell cycle genes", "protein_name": "[{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Cyclin-G2\",\"id\":\"Q16589\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"Forkhead box protein G1\",\"id\":\"P55316\"},{\"label\":\"Forkhead box protein O1\",\"id\":\"Q12778\"},{\"label\":\"Forkhead box protein O3\",\"id\":\"O43524\"},{\"label\":\"Forkhead box protein O4\",\"id\":\"P98177\"},{\"label\":\"Growth arrest and DNA damage-inducible protein GADD45 alpha\",\"id\":\"P24522\"},{\"label\":\"Growth/differentiation factor 8\",\"id\":\"O14793\"},{\"label\":\"Krueppel-like factor 4\",\"id\":\"O43474\"},{\"label\":\"Mothers against decapentaplegic homolog 2\",\"id\":\"Q15796\"},{\"label\":\"Mothers against decapentaplegic homolog 3\",\"id\":\"P84022\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"Poly(rC)-binding protein 4\",\"id\":\"P57723\"},{\"label\":\"Protein BTG1\",\"id\":\"P62324\"},{\"label\":\"Retinoblastoma-like protein 2\",\"id\":\"Q08999\"}]", "uniprot_id": "[\"O14793\",\"O43474\",\"O43524\",\"P24522\",\"P38936\",\"P46527\",\"P55316\",\"P57723\",\"P62324\",\"P84022\",\"P98177\",\"Q03135\",\"Q08999\",\"Q12778\",\"Q13485\",\"Q15796\",\"Q16589\"]", "gene_symbol": 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10\",\"id\":\"Q9UM13\"},{\"label\":\"Anaphase-promoting complex subunit 11\",\"id\":\"Q9NYG5\"},{\"label\":\"Anaphase-promoting complex subunit 15\",\"id\":\"P60006\"},{\"label\":\"Anaphase-promoting complex subunit 16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 5\",\"id\":\"Q9UJX4\"},{\"label\":\"Anaphase-promoting complex subunit 7\",\"id\":\"Q9UJX3\"},{\"label\":\"Anaphase-promoting complex subunit CDC26\",\"id\":\"Q8NHZ8\"},{\"label\":\"Cell division cycle protein 16 homolog\",\"id\":\"Q13042\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Cell division cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Mitotic checkpoint protein BUB3\",\"id\":\"O43684\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta\",\"id\":\"O60566\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2A\",\"id\":\"Q13257\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"}]", "uniprot_id": "[\"O00762\",\"O43684\",\"O60566\",\"P30260\",\"P51668\",\"P51965\",\"P60006\",\"Q12834\",\"Q13042\",\"Q13257\",\"Q16763\",\"Q8NHZ8\",\"Q96DE5\",\"Q9H1A4\",\"Q9NYG5\",\"Q9UJX2\",\"Q9UJX3\",\"Q9UJX4\",\"Q9UJX5\",\"Q9UJX6\",\"Q9UM13\"]", "gene_symbol": 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6\",\"id\":\"O43306\"},{\"label\":\"Adenylate cyclase type 7\",\"id\":\"P51828\"},{\"label\":\"Adenylate cyclase type 8\",\"id\":\"P40145\"},{\"label\":\"Adenylate cyclase type 9\",\"id\":\"O60503\"},{\"label\":\"Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas\",\"id\":\"Q5JWF2\"},{\"label\":\"Guanine nucleotide-binding protein G(s) subunit alpha isoforms short\",\"id\":\"P63092\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"},{\"label\":\"cAMP-dependent protein kinase type I-alpha regulatory subunit\",\"id\":\"P10644\"},{\"label\":\"cAMP-dependent protein kinase type I-beta regulatory subunit\",\"id\":\"P31321\"},{\"label\":\"cAMP-dependent protein kinase type II-alpha regulatory subunit\",\"id\":\"P13861\"},{\"label\":\"cAMP-dependent protein kinase type II-beta regulatory subunit\",\"id\":\"P31323\"}]", "uniprot_id": "[\"O43306\",\"O60266\",\"O60503\",\"O95622\",\"P10644\",\"P13861\",\"P17612\",\"P22612\",\"P22694\",\"P31321\",\"P31323\",\"P40145\",\"P51828\",\"P63092\",\"Q08462\",\"Q08828\",\"Q5JWF2\",\"Q8NFM4\"]", "gene_symbol": "[\"ADCY1\",\"ADCY2\",\"ADCY3\",\"ADCY4\",\"ADCY5\",\"ADCY6\",\"ADCY7\",\"ADCY8\",\"ADCY9\",\"GNAS\",\"GNAS1\",\"GSP\",\"KIAA0037\",\"KIAA0422\",\"KIAA0511\",\"KIAA0520\",\"KIAA1060\",\"PKACA\",\"PKR1\",\"PKR2\",\"PRKACA\",\"PRKACB\",\"PRKACG\",\"PRKAR1\",\"PRKAR1A\",\"PRKAR1B\",\"PRKAR2\",\"PRKAR2A\",\"PRKAR2B\",\"TSE1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Integrin cell surface interactions", "protein_name": "[{\"label\":\"Agrin\",\"id\":\"O00468\"},{\"label\":\"Basement membrane-specific heparan sulfate proteoglycan core protein\",\"id\":\"P98160\"},{\"label\":\"Basigin\",\"id\":\"P35613\"},{\"label\":\"CD44 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chain\",\"id\":\"P02675\"},{\"label\":\"Fibrinogen gamma chain\",\"id\":\"P02679\"},{\"label\":\"Fibronectin\",\"id\":\"P02751\"},{\"label\":\"Integrin alpha-10\",\"id\":\"O75578\"},{\"label\":\"Integrin alpha-11\",\"id\":\"Q9UKX5\"},{\"label\":\"Integrin alpha-1\",\"id\":\"P56199\"},{\"label\":\"Integrin alpha-2\",\"id\":\"P17301\"},{\"label\":\"Integrin alpha-3\",\"id\":\"P26006\"},{\"label\":\"Integrin alpha-4\",\"id\":\"P13612\"},{\"label\":\"Integrin alpha-5\",\"id\":\"P08648\"},{\"label\":\"Integrin alpha-6\",\"id\":\"P23229\"},{\"label\":\"Integrin alpha-7\",\"id\":\"Q13683\"},{\"label\":\"Integrin alpha-8\",\"id\":\"P53708\"},{\"label\":\"Integrin alpha-9\",\"id\":\"Q13797\"},{\"label\":\"Integrin alpha-D\",\"id\":\"Q13349\"},{\"label\":\"Integrin alpha-E\",\"id\":\"P38570\"},{\"label\":\"Integrin alpha-IIb\",\"id\":\"P08514\"},{\"label\":\"Integrin alpha-L\",\"id\":\"P20701\"},{\"label\":\"Integrin alpha-M\",\"id\":\"P11215\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin alpha-X\",\"id\":\"P20702\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin beta-2\",\"id\":\"P05107\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Integrin beta-5\",\"id\":\"P18084\"},{\"label\":\"Integrin beta-6\",\"id\":\"P18564\"},{\"label\":\"Integrin beta-7\",\"id\":\"P26010\"},{\"label\":\"Integrin beta-8\",\"id\":\"P26012\"},{\"label\":\"Integrin-binding sialoprotein\",\"id\":\"P21815\"},{\"label\":\"Intercellular adhesion molecule 1\",\"id\":\"P05362\"},{\"label\":\"Intercellular adhesion molecule 2\",\"id\":\"P13598\"},{\"label\":\"Intercellular adhesion molecule 3\",\"id\":\"P32942\"},{\"label\":\"Intercellular adhesion molecule 4\",\"id\":\"Q14773\"},{\"label\":\"Intercellular adhesion molecule 5\",\"id\":\"Q9UMF0\"},{\"label\":\"Junctional adhesion molecule A\",\"id\":\"Q9Y624\"},{\"label\":\"Junctional adhesion molecule B\",\"id\":\"P57087\"},{\"label\":\"Junctional adhesion molecule C\",\"id\":\"Q9BX67\"},{\"label\":\"Leukocyte surface antigen CD47\",\"id\":\"Q08722\"},{\"label\":\"Lumican\",\"id\":\"P51884\"},{\"label\":\"Osteopontin\",\"id\":\"P10451\"},{\"label\":\"Platelet endothelial cell adhesion molecule\",\"id\":\"P16284\"},{\"label\":\"Tenascin\",\"id\":\"P24821\"},{\"label\":\"Thrombospondin-1\",\"id\":\"P07996\"},{\"label\":\"Vascular cell adhesion protein 1\",\"id\":\"P19320\"},{\"label\":\"Vascular endothelial growth factor receptor 2\",\"id\":\"P35968\"},{\"label\":\"Vitronectin\",\"id\":\"P04004\"}]", "uniprot_id": 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"[\"AGRIN\",\"AGRN\",\"BNSP\",\"BSG\",\"C21orf43\",\"CD11A\",\"CD11B\",\"CD11C\",\"CD18\",\"CD44\",\"CD47\",\"CD49B\",\"CD49D\",\"CDH1\",\"CDHE\",\"COL13A1\",\"COL16A1\",\"COL18A1\",\"COL23A1\",\"COL4A1\",\"COL4A2\",\"COL4A3\",\"COL4A4\",\"COL9A1\",\"COL9A2\",\"COL9A3\",\"COMP\",\"CR3A\",\"F11R\",\"FBN\",\"FBN1\",\"FGA\",\"FGB\",\"FGG\",\"FLK1\",\"FN\",\"FN1\",\"FNRA\",\"FNRB\",\"GP2B\",\"GP3A\",\"HSPG2\",\"HXB\",\"IBSP\",\"ICAM1\",\"ICAM2\",\"ICAM3\",\"ICAM4\",\"ICAM5\",\"ITGA1\",\"ITGA10\",\"ITGA11\",\"ITGA2\",\"ITGA2B\",\"ITGA3\",\"ITGA4\",\"ITGA5\",\"ITGA6\",\"ITGA7\",\"ITGA8\",\"ITGA9\",\"ITGAB\",\"ITGAD\",\"ITGAE\",\"ITGAL\",\"ITGAM\",\"ITGAV\",\"ITGAX\",\"ITGB1\",\"ITGB2\",\"ITGB3\",\"ITGB5\",\"ITGB6\",\"ITGB7\",\"ITGB8\",\"JAM1\",\"JAM2\",\"JAM3\",\"JCAM\",\"KDR\",\"LDC\",\"LHR\",\"LUM\",\"LW\",\"MDF2\",\"MDU2\",\"MDU3\",\"MER6\",\"MFI7\",\"MIC4\",\"MSK12\",\"MSK18\",\"MSK8\",\"OPN\",\"PECAM1\",\"SLRR2D\",\"SPP1\",\"THBS1\",\"TLCN\",\"TLN\",\"TNC\",\"TSP\",\"TSP1\",\"UVO\",\"VCAM1\",\"VEGFR2\",\"VEJAM\",\"VNRA\",\"VTN\",\"VTNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of selenosugars for excretion", "protein_name": null, "uniprot_id": "[\"\"]", "gene_symbol": "[\"\"]", "gtc_id": "[\"G61418DU\"]" }, { "pathway_label": "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "protein_name": "[{\"label\":\"Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial\",\"id\":\"Q9BQ95\"},{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"Interleukin-1 receptor-associated kinase 4\",\"id\":\"Q9NWZ3\"},{\"label\":\"Interleukin-1 receptor-associated kinase-like 2\",\"id\":\"O43187\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 1\",\"id\":\"Q13233\"},{\"label\":\"Myeloid differentiation primary response protein MyD88\",\"id\":\"Q99836\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Toll-like receptor 7\",\"id\":\"Q9NYK1\"},{\"label\":\"Toll-like receptor 9\",\"id\":\"Q9NR96\"}]", "uniprot_id": "[\"O43187\",\"P51617\",\"Q13233\",\"Q99836\",\"Q9BQ95\",\"Q9NR96\",\"Q9NWZ3\",\"Q9NYK1\",\"Q9Y4K3\"]", "gene_symbol": "[\"ECSIT\",\"IRAK\",\"IRAK1\",\"IRAK2\",\"IRAK4\",\"MAP3K1\",\"MAPKKK1\",\"MEKK\",\"MEKK1\",\"MYD88\",\"RNF85\",\"TLR7\",\"TLR9\",\"TRAF6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "GSD 0 (muscle)", "protein_name": "[{\"label\":\"Glycogen [starch] synthase, muscle\",\"id\":\"P13807\"},{\"label\":\"Glycogenin-1\",\"id\":\"P46976\"}]", "uniprot_id": "[\"P13807\",\"P46976\"]", "gene_symbol": "[\"GYG\",\"GYG1\",\"GYS\",\"GYS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SARS-CoV-2 activates/modulates innate and adaptive immune responses", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Antiviral innate immune response receptor RIG-I\",\"id\":\"O95786\"},{\"label\":\"Beclin 1-associated autophagy-related key regulator\",\"id\":\"Q6ZNE5\"},{\"label\":\"Beclin-1\",\"id\":\"Q14457\"},{\"label\":\"Beta-2-microglobulin\",\"id\":\"P61769\"},{\"label\":\"CCHC-type zinc finger nucleic acid binding protein\",\"id\":\"P62633\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"E3 ubiquitin-protein ligase RNF135\",\"id\":\"Q8IUD6\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM4\",\"id\":\"Q9C037\"},{\"label\":\"E3 ubiquitin/ISG15 ligase TRIM25\",\"id\":\"Q14258\"},{\"label\":\"Envelope small membrane protein\",\"id\":\"P0DTC4\"},{\"label\":\"HLA class I histocompatibility antigen, A alpha chain\",\"id\":\"P04439\"},{\"label\":\"HLA class I histocompatibility antigen, B alpha chain\",\"id\":\"P01889\"},{\"label\":\"HLA class I histocompatibility antigen, C alpha chain\",\"id\":\"P10321\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain E\",\"id\":\"P13747\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain F\",\"id\":\"P30511\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain G\",\"id\":\"P17693\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Importin subunit alpha-1\",\"id\":\"P52292\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit epsilon\",\"id\":\"Q14164\"},{\"label\":\"Interferon alpha-1/13\",\"id\":\"P01562\"},{\"label\":\"Interferon alpha-10\",\"id\":\"P01566\"},{\"label\":\"Interferon alpha-14\",\"id\":\"P01570\"},{\"label\":\"Interferon alpha-16\",\"id\":\"P05015\"},{\"label\":\"Interferon alpha-17\",\"id\":\"P01571\"},{\"label\":\"Interferon alpha-21\",\"id\":\"P01568\"},{\"label\":\"Interferon alpha-2\",\"id\":\"P01563\"},{\"label\":\"Interferon alpha-4\",\"id\":\"P05014\"},{\"label\":\"Interferon alpha-5\",\"id\":\"P01569\"},{\"label\":\"Interferon alpha-6\",\"id\":\"P05013\"},{\"label\":\"Interferon alpha-7\",\"id\":\"P01567\"},{\"label\":\"Interferon alpha-8\",\"id\":\"P32881\"},{\"label\":\"Interferon alpha/beta receptor 1\",\"id\":\"P17181\"},{\"label\":\"Interferon beta\",\"id\":\"P01574\"},{\"label\":\"Interferon regulatory factor 3\",\"id\":\"Q14653\"},{\"label\":\"Interferon regulatory factor 7\",\"id\":\"Q92985\"},{\"label\":\"Interferon-induced helicase C domain-containing protein 1\",\"id\":\"Q9BYX4\"},{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"Interleukin-1 receptor-associated kinase-like 2\",\"id\":\"O43187\"},{\"label\":\"Interleukin-17 receptor A\",\"id\":\"Q96F46\"},{\"label\":\"Interleukin-17 receptor C\",\"id\":\"Q8NAC3\"},{\"label\":\"Interleukin-17A\",\"id\":\"Q16552\"},{\"label\":\"Interleukin-17F\",\"id\":\"Q96PD4\"},{\"label\":\"La-related protein 1\",\"id\":\"Q6PKG0\"},{\"label\":\"Mannan-binding lectin serine protease 1\",\"id\":\"P48740\"},{\"label\":\"Mannose-binding protein C\",\"id\":\"P11226\"},{\"label\":\"Membrane protein\",\"id\":\"P0DTC5\"},{\"label\":\"Mitochondrial antiviral-signaling protein\",\"id\":\"Q7Z434\"},{\"label\":\"Mitochondrial import receptor subunit TOM70\",\"id\":\"O94826\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 7\",\"id\":\"O43318\"},{\"label\":\"NACHT, LRR and PYD domains-containing protein 12\",\"id\":\"P59046\"},{\"label\":\"NACHT, LRR and PYD domains-containing protein 3\",\"id\":\"Q96P20\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective ALG6 causes CDG-1c", "protein_name": "[{\"label\":\"Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase\",\"id\":\"Q9Y672\"}]", "uniprot_id": "[\"Q9Y672\"]", "gene_symbol": "[\"ALG6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Toxicity of botulinum toxin type B (botB)", "protein_name": "[{\"label\":\"Botulinum neurotoxin type B\",\"id\":\"P10844\"},{\"label\":\"HA-17\",\"id\":\"Q45878\"},{\"label\":\"HA-33 protein\",\"id\":\"Q57230\"},{\"label\":\"Ha70 protein\",\"id\":\"Q45877\"},{\"label\":\"NTNHA\",\"id\":\"Q9LBS8\"},{\"label\":\"Synaptotagmin-1\",\"id\":\"P21579\"},{\"label\":\"Synaptotagmin-2\",\"id\":\"Q8N9I0\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"}]", "uniprot_id": "[\"P10844\",\"P21579\",\"P63027\",\"Q45877\",\"Q45878\",\"Q57230\",\"Q8N9I0\",\"Q9LBS8\"]", "gene_symbol": "[\"HA\",\"HA-17\",\"HA-33\",\"SVP65\",\"SYB2\",\"SYT\",\"SYT1\",\"SYT2\",\"VAMP2\",\"botB\",\"ha17\",\"ha34\",\"ha70\",\"ntnha\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ras activation upon Ca2+ influx through NMDA receptor", "protein_name": "[{\"label\":\"Alpha-actinin-2\",\"id\":\"P35609\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Disks large homolog 1\",\"id\":\"Q12959\"},{\"label\":\"Disks large homolog 2\",\"id\":\"Q15700\"},{\"label\":\"Disks large homolog 3\",\"id\":\"Q92796\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 1\",\"id\":\"Q05586\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2D\",\"id\":\"O15399\"},{\"label\":\"Leucine-rich repeat-containing protein 7\",\"id\":\"Q96NW7\"},{\"label\":\"Neurofilament light polypeptide\",\"id\":\"P07196\"},{\"label\":\"Ras-specific guanine nucleotide-releasing factor 1\",\"id\":\"Q13972\"},{\"label\":\"Ras-specific guanine nucleotide-releasing factor 2\",\"id\":\"O14827\"}]", "uniprot_id": "[\"O14827\",\"O15399\",\"P01111\",\"P01112\",\"P07196\",\"P0DP23\",\"P35609\",\"P78352\",\"Q05586\",\"Q12959\",\"Q13224\",\"Q13554\",\"Q13555\",\"Q13557\",\"Q13972\",\"Q15700\",\"Q92796\",\"Q96NW7\",\"Q9UQM7\"]", "gene_symbol": "[\"ACTN2\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAM2\",\"CAMK\",\"CAMK-II\",\"CAMK2\",\"CAMK2A\",\"CAMK2B\",\"CAMK2D\",\"CAMK2G\",\"CAMKA\",\"CAMKB\",\"CAMKD\",\"CAMKG\",\"CDC25\",\"DLG1\",\"DLG2\",\"DLG3\",\"DLG4\",\"GNRP\",\"GRF1\",\"GRF2\",\"GRIN1\",\"GRIN2B\",\"GRIN2D\",\"GluN2D\",\"HRAS\",\"HRAS1\",\"KIAA0968\",\"KIAA1232\",\"KIAA1365\",\"LAP1\",\"LRRC7\",\"NEFL\",\"NF68\",\"NFL\",\"NMDAR1\",\"NMDAR2B\",\"NMDAR2D\",\"NRAS\",\"PSD95\",\"RASGRF1\",\"RASGRF2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Clathrin-mediated endocytosis", "protein_name": "[{\"label\":\"ADP-ribosylation factor 6\",\"id\":\"P62330\"},{\"label\":\"ADP-ribosylation factor GTPase-activating protein 1\",\"id\":\"Q8N6T3\"},{\"label\":\"AP-2 complex subunit alpha-1\",\"id\":\"O95782\"},{\"label\":\"AP-2 complex subunit alpha-2\",\"id\":\"O94973\"},{\"label\":\"AP-2 complex subunit beta\",\"id\":\"P63010\"},{\"label\":\"AP-2 complex subunit mu\",\"id\":\"Q96CW1\"},{\"label\":\"AP-2 complex subunit sigma\",\"id\":\"P53680\"},{\"label\":\"AP2-associated protein kinase 1\",\"id\":\"Q2M2I8\"},{\"label\":\"Actin nucleation-promoting factor WASL\",\"id\":\"O00401\"},{\"label\":\"Actin-related protein 2/3 complex subunit 1A\",\"id\":\"Q92747\"},{\"label\":\"Actin-related protein 2/3 complex subunit 2\",\"id\":\"O15144\"},{\"label\":\"Actin-related protein 2/3 complex subunit 3\",\"id\":\"O15145\"},{\"label\":\"Actin-related protein 2/3 complex subunit 4\",\"id\":\"P59998\"},{\"label\":\"Actin-related protein 2/3 complex subunit 5\",\"id\":\"O15511\"},{\"label\":\"Actin-related protein 2\",\"id\":\"P61160\"},{\"label\":\"Actin-related protein 3\",\"id\":\"P61158\"},{\"label\":\"Adaptin ear-binding coat-associated protein 1\",\"id\":\"Q8NC96\"},{\"label\":\"Adaptin ear-binding coat-associated protein 2\",\"id\":\"Q9NVZ3\"},{\"label\":\"Amphiphysin\",\"id\":\"P49418\"},{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Arf-GAP domain and FG repeat-containing protein 1\",\"id\":\"P52594\"},{\"label\":\"Auxilin\",\"id\":\"O75061\"},{\"label\":\"Beta-2 adrenergic receptor\",\"id\":\"P07550\"},{\"label\":\"Beta-arrestin-1\",\"id\":\"P49407\"},{\"label\":\"Beta-arrestin-2\",\"id\":\"P32121\"},{\"label\":\"Cation-dependent mannose-6-phosphate receptor\",\"id\":\"P20645\"},{\"label\":\"Cation-independent mannose-6-phosphate receptor\",\"id\":\"P11717\"},{\"label\":\"Cdc42-interacting protein 4\",\"id\":\"Q15642\"},{\"label\":\"Clathrin coat assembly protein AP180\",\"id\":\"O60641\"},{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Clathrin heavy chain 2\",\"id\":\"P53675\"},{\"label\":\"Clathrin light chain A\",\"id\":\"P09496\"},{\"label\":\"Clathrin light chain B\",\"id\":\"P09497\"},{\"label\":\"Cyclin-G-associated kinase\",\"id\":\"O14976\"},{\"label\":\"Cystic fibrosis transmembrane conductance regulator\",\"id\":\"P13569\"},{\"label\":\"Disabled homolog 2\",\"id\":\"P98082\"},{\"label\":\"Dynamin-1\",\"id\":\"Q05193\"},{\"label\":\"Dynamin-2\",\"id\":\"P50570\"},{\"label\":\"Dynamin-3\",\"id\":\"Q9UQ16\"},{\"label\":\"Dyslexia-associated protein KIAA0319\",\"id\":\"Q5VV43\"},{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Endophilin-A1\",\"id\":\"Q99962\"},{\"label\":\"Endophilin-A2\",\"id\":\"Q99961\"},{\"label\":\"Endophilin-A3\",\"id\":\"Q99963\"},{\"label\":\"Epidermal growth factor receptor substrate 15-like 1\",\"id\":\"Q9UBC2\"},{\"label\":\"Epidermal growth factor receptor substrate 15\",\"id\":\"P42566\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Epigen\",\"id\":\"Q6UW88\"},{\"label\":\"Epsin-1\",\"id\":\"Q9Y6I3\"},{\"label\":\"Epsin-2\",\"id\":\"O95208\"},{\"label\":\"F-BAR domain only protein 1\",\"id\":\"O14526\"},{\"label\":\"F-BAR domain only protein 2\",\"id\":\"Q0JRZ9\"},{\"label\":\"Formin-binding protein 1-like\",\"id\":\"Q5T0N5\"},{\"label\":\"Formin-binding protein 1\",\"id\":\"Q96RU3\"},{\"label\":\"Frizzled-4\",\"id\":\"Q9ULV1\"},{\"label\":\"GTPase-activating protein and VPS9 domain-containing protein 1\",\"id\":\"Q14C86\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Hepatocyte growth factor-regulated tyrosine kinase substrate\",\"id\":\"O14964\"},{\"label\":\"Huntingtin-interacting protein 1-related protein\",\"id\":\"O75146\"},{\"label\":\"Huntingtin-interacting protein 1\",\"id\":\"O00291\"},{\"label\":\"Inositol polyphosphate 5-phosphatase OCRL\",\"id\":\"Q01968\"},{\"label\":\"Interleukin-7 receptor subunit alpha\",\"id\":\"P16871\"},{\"label\":\"Intersectin-1\",\"id\":\"Q15811\"},{\"label\":\"Intersectin-2\",\"id\":\"Q9NZM3\"},{\"label\":\"Low density lipoprotein receptor adapter protein 1\",\"id\":\"Q5SW96\"},{\"label\":\"Low-density lipoprotein receptor-related protein 2\",\"id\":\"P98164\"},{\"label\":\"Low-density lipoprotein receptor\",\"id\":\"P01130\"},{\"label\":\"Lysosome membrane protein 2\",\"id\":\"Q14108\"},{\"label\":\"Muscarinic acetylcholine receptor M2\",\"id\":\"P08172\"},{\"label\":\"Myc box-dependent-interacting protein 1\",\"id\":\"O00499\"},{\"label\":\"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha\",\"id\":\"O00443\"},{\"label\":\"Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma\",\"id\":\"O60331\"},{\"label\":\"Phosphatidylinositol-binding clathrin assembly protein\",\"id\":\"Q13492\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Protein kinase C and casein kinase substrate in neurons protein 1\",\"id\":\"Q9BY11\"},{\"label\":\"Protein kinase C and casein kinase substrate in neurons protein 2\",\"id\":\"Q9UNF0\"},{\"label\":\"Protein kinase C and casein kinase substrate in neurons protein 3\",\"id\":\"Q9UKS6\"},{\"label\":\"Protransforming growth factor alpha\",\"id\":\"P01135\"},{\"label\":\"RalBP1-associated Eps domain-containing protein 1\",\"id\":\"Q96D71\"},{\"label\":\"RalBP1-associated Eps domain-containing protein 2\",\"id\":\"Q8NFH8\"},{\"label\":\"Ras-related protein Rab-5A\",\"id\":\"P20339\"},{\"label\":\"Ras-related protein Rab-5B\",\"id\":\"P61020\"},{\"label\":\"Ras-related protein Rab-5C\",\"id\":\"P51148\"},{\"label\":\"SH3 domain-containing kinase-binding protein 1\",\"id\":\"Q96B97\"},{\"label\":\"SH3-containing GRB2-like protein 3-interacting protein 1\",\"id\":\"Q9BQI5\"},{\"label\":\"Segment polarity protein dishevelled homolog 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factor\",\"id\":\"P39905\"},{\"label\":\"Growth factor receptor-bound protein 10\",\"id\":\"Q13322\"},{\"label\":\"Growth factor receptor-bound protein 7\",\"id\":\"Q14451\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Mitogen-activated protein kinase 7\",\"id\":\"Q13164\"},{\"label\":\"Neurturin\",\"id\":\"Q99748\"},{\"label\":\"PDZ and LIM domain protein 7\",\"id\":\"Q9NR12\"},{\"label\":\"Persephin\",\"id\":\"O60542\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform\",\"id\":\"O00329\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase receptor Ret\",\"id\":\"P07949\"},{\"label\":\"Rap1 GTPase-activating protein 1\",\"id\":\"P47736\"},{\"label\":\"SH3 and multiple ankyrin repeat domains protein 3\",\"id\":\"Q9BYB0\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"SHC-transforming protein 3\",\"id\":\"Q92529\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": 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SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)", "protein_name": "[{\"label\":\"Sodium-dependent dopamine transporter\",\"id\":\"Q01959\"}]", "uniprot_id": "[\"Q01959\"]", "gene_symbol": "[\"DAT1\",\"SLC6A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane", "protein_name": "[{\"label\":\"ADP-ribosylation factor-like protein 2-binding protein\",\"id\":\"Q9Y2Y0\"},{\"label\":\"ADP-ribosylation factor-like protein 2\",\"id\":\"P36404\"},{\"label\":\"ADP/ATP translocase 1\",\"id\":\"P12235\"},{\"label\":\"ADP/ATP translocase 2\",\"id\":\"P05141\"},{\"label\":\"ADP/ATP translocase 3\",\"id\":\"P12236\"},{\"label\":\"Equilibrative nucleoside transporter 1\",\"id\":\"Q99808\"},{\"label\":\"Equilibrative nucleoside transporter 2\",\"id\":\"Q14542\"},{\"label\":\"Equilibrative nucleoside transporter 3\",\"id\":\"Q9BZD2\"},{\"label\":\"Equilibrative nucleoside transporter 4\",\"id\":\"Q7RTT9\"},{\"label\":\"Sodium/nucleoside cotransporter 1\",\"id\":\"O00337\"},{\"label\":\"Sodium/nucleoside cotransporter 2\",\"id\":\"O43868\"},{\"label\":\"Solute carrier family 28 member 3\",\"id\":\"Q9HAS3\"}]", "uniprot_id": "[\"O00337\",\"O43868\",\"P05141\",\"P12235\",\"P12236\",\"P36404\",\"Q14542\",\"Q7RTT9\",\"Q99808\",\"Q9BZD2\",\"Q9HAS3\",\"Q9Y2Y0\"]", "gene_symbol": "[\"AAC1\",\"AAC2\",\"AAC3\",\"ANT1\",\"ANT2\",\"ANT3\",\"ARL2\",\"ARL2BP\",\"BART\",\"BART1\",\"CNT1\",\"CNT2\",\"CNT3\",\"DER12\",\"ENT1\",\"ENT2\",\"ENT3\",\"ENT4\",\"HNP36\",\"PMAT\",\"SLC25A4\",\"SLC25A5\",\"SLC25A6\",\"SLC28A1\",\"SLC28A2\",\"SLC28A3\",\"SLC29A1\",\"SLC29A2\",\"SLC29A3\",\"SLC29A4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Budding and maturation of HIV virion", "protein_name": "[{\"label\":\"Charged multivesicular body protein 2a\",\"id\":\"O43633\"},{\"label\":\"Charged multivesicular body protein 2b\",\"id\":\"Q9UQN3\"},{\"label\":\"Charged multivesicular body protein 3\",\"id\":\"Q9Y3E7\"},{\"label\":\"Charged multivesicular body protein 4a\",\"id\":\"Q9BY43\"},{\"label\":\"Charged multivesicular body protein 4b\",\"id\":\"Q9H444\"},{\"label\":\"Charged multivesicular body protein 4c\",\"id\":\"Q96CF2\"},{\"label\":\"Charged multivesicular body protein 5\",\"id\":\"Q9NZZ3\"},{\"label\":\"Charged multivesicular body protein 6\",\"id\":\"Q96FZ7\"},{\"label\":\"Charged multivesicular body protein 7\",\"id\":\"Q8WUX9\"},{\"label\":\"E3 ubiquitin-protein ligase NEDD4-like\",\"id\":\"Q96PU5\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04578\"},{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"Multivesicular body subunit 12A\",\"id\":\"Q96EY5\"},{\"label\":\"Multivesicular body subunit 12B\",\"id\":\"Q9H7P6\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Programmed cell death 6-interacting protein\",\"id\":\"Q8WUM4\"},{\"label\":\"Protein Nef\",\"id\":\"P04601\"},{\"label\":\"Protein Rev\",\"id\":\"P04618\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"Tumor susceptibility gene 101 protein\",\"id\":\"Q99816\"},{\"label\":\"Ubiquitin-associated protein 1\",\"id\":\"Q9NZ09\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Vacuolar protein sorting-associated protein 28 homolog\",\"id\":\"Q9UK41\"},{\"label\":\"Vacuolar protein sorting-associated protein 37A\",\"id\":\"Q8NEZ2\"},{\"label\":\"Vacuolar protein sorting-associated protein 37B\",\"id\":\"Q9H9H4\"},{\"label\":\"Vacuolar protein sorting-associated protein 37C\",\"id\":\"A5D8V6\"},{\"label\":\"Vacuolar protein sorting-associated protein 37D\",\"id\":\"Q86XT2\"},{\"label\":\"Vacuolar protein sorting-associated protein 4A\",\"id\":\"Q9UN37\"},{\"label\":\"Vacuolar protein sorting-associated protein 4B\",\"id\":\"O75351\"},{\"label\":\"Vacuolar protein sorting-associated protein VTA1 homolog\",\"id\":\"Q9NP79\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"A5D8V6\",\"O43633\",\"O75351\",\"P04578\",\"P04585\",\"P04591\",\"P04601\",\"P04618\",\"P05919\",\"P0CG47\",\"P0CG48\",\"P62937\",\"P62979\",\"P62987\",\"P69723\",\"P69726\",\"Q86XT2\",\"Q8NEZ2\",\"Q8WUM4\",\"Q8WUX9\",\"Q96CF2\",\"Q96EY5\",\"Q96FZ7\",\"Q96PU5\",\"Q99816\",\"Q9BY43\",\"Q9H444\",\"Q9H7P6\",\"Q9H9H4\",\"Q9NP79\",\"Q9NZ09\",\"Q9NZZ3\",\"Q9UK41\",\"Q9UN37\",\"Q9UQN3\",\"Q9Y3E7\"]", "gene_symbol": 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1\",\"id\":\"Q13546\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 10\",\"id\":\"P50591\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 6\",\"id\":\"P48023\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10A\",\"id\":\"O00220\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10B\",\"id\":\"O14763\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 6\",\"id\":\"P25445\"},{\"label\":\"Tumor necrosis factor receptor type 1-associated DEATH domain protein\",\"id\":\"Q15628\"}]", "uniprot_id": "[\"O00220\",\"O14763\",\"P25445\",\"P48023\",\"P50591\",\"Q12933\",\"Q13158\",\"Q13546\",\"Q14790\",\"Q15628\"]", "gene_symbol": 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protein\",\"id\":\"Q9NP71\"},{\"label\":\"Serine/threonine-protein kinase STK11\",\"id\":\"Q15831\"}]", "uniprot_id": "[\"O43741\",\"P54646\",\"Q15831\",\"Q15848\",\"Q86V24\",\"Q96A54\",\"Q9NP71\",\"Q9UGJ0\"]", "gene_symbol": "[\"ACDC\",\"ACRP30\",\"ADIPOQ\",\"ADIPOR1\",\"ADIPOR2\",\"AMPK\",\"AMPK2\",\"APM1\",\"BHLHD14\",\"GBP28\",\"LKB1\",\"MIO\",\"MLXIPL\",\"PAQR1\",\"PAQR2\",\"PJS\",\"PRKAA2\",\"PRKAB2\",\"PRKAG2\",\"STK11\",\"TESBP1A\",\"WBSCR14\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NVP-TAE684-resistant ALK mutants", "protein_name": "[{\"label\":\"ALK tyrosine kinase receptor\",\"id\":\"Q9UM73\"}]", "uniprot_id": "[\"Q9UM73\"]", "gene_symbol": "[\"ALK\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Complex I biogenesis", "protein_name": "[{\"label\":\"Acyl carrier protein, mitochondrial\",\"id\":\"O14561\"},{\"label\":\"Arginine-hydroxylase NDUFAF5, mitochondrial\",\"id\":\"Q5TEU4\"},{\"label\":\"Complex I assembly factor ACAD9, mitochondrial\",\"id\":\"Q9H845\"},{\"label\":\"Complex I assembly factor TIMMDC1, mitochondrial\",\"id\":\"Q9NPL8\"},{\"label\":\"Complex I assembly factor TMEM126B, mitochondrial\",\"id\":\"Q8IUX1\"},{\"label\":\"Complex I intermediate-associated protein 30, mitochondrial\",\"id\":\"Q9Y375\"},{\"label\":\"Cytochrome c oxidase assembly factor 1 homolog\",\"id\":\"Q9GZY4\"},{\"label\":\"Distal membrane-arm assembly complex protein 1\",\"id\":\"Q96GE9\"},{\"label\":\"Distal membrane-arm assembly complex protein 2\",\"id\":\"Q9NW81\"},{\"label\":\"Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial\",\"id\":\"Q9BQ95\"},{\"label\":\"FAD-dependent oxidoreductase domain-containing protein 1\",\"id\":\"Q96CU9\"},{\"label\":\"Iron-sulfur cluster co-chaperone protein HscB\",\"id\":\"Q8IWL3\"},{\"label\":\"Iron-sulfur cluster transfer protein NUBPL\",\"id\":\"Q8TB37\"},{\"label\":\"LYR motif-containing protein 2\",\"id\":\"Q9NU23\"},{\"label\":\"Mitochondrial inner membrane protein OXA1L\",\"id\":\"Q15070\"},{\"label\":\"NADH dehydrogenase (ubiquinone) complex I, assembly factor 6\",\"id\":\"Q330K2\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2\",\"id\":\"Q8N183\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3\",\"id\":\"Q9BU61\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4\",\"id\":\"Q9P032\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8\",\"id\":\"A1L188\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial\",\"id\":\"O95299\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11\",\"id\":\"Q86Y39\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12\",\"id\":\"Q9UI09\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13\",\"id\":\"Q9P0J0\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1\",\"id\":\"O15239\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2\",\"id\":\"O43678\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3\",\"id\":\"O95167\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5\",\"id\":\"Q16718\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6\",\"id\":\"P56556\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7\",\"id\":\"O95182\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8\",\"id\":\"P51970\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial\",\"id\":\"Q16795\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10\",\"id\":\"O96000\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial\",\"id\":\"Q9NX14\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1\",\"id\":\"O75438\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial\",\"id\":\"O95178\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3\",\"id\":\"O43676\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4\",\"id\":\"O95168\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial\",\"id\":\"O43674\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6\",\"id\":\"O95139\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7\",\"id\":\"P17568\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial\",\"id\":\"O95169\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9\",\"id\":\"Q9Y6M9\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial\",\"id\":\"O43677\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 subunit C2\",\"id\":\"O95298\"},{\"label\":\"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial\",\"id\":\"P49821\"},{\"label\":\"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial\",\"id\":\"P19404\"},{\"label\":\"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial\",\"id\":\"P56181\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial\",\"id\":\"O75306\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial\",\"id\":\"O75489\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial\",\"id\":\"O43181\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5\",\"id\":\"O43920\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial\",\"id\":\"O75380\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial\",\"id\":\"O75251\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial\",\"id\":\"O00217\"},{\"label\":\"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial\",\"id\":\"P28331\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 1\",\"id\":\"P03886\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 2\",\"id\":\"P03891\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 3\",\"id\":\"P03897\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 4\",\"id\":\"P03905\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 5\",\"id\":\"P03915\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 6\",\"id\":\"P03923\"},{\"label\":\"Protein arginine methyltransferase NDUFAF7, mitochondrial\",\"id\":\"Q7L592\"},{\"label\":\"Protein preY, mitochondrial\",\"id\":\"Q96I23\"},{\"label\":\"Sideroflexin-4\",\"id\":\"Q6P4A7\"},{\"label\":\"Stress-70 protein, mitochondrial\",\"id\":\"P38646\"},{\"label\":\"Transmembrane protein 126A\",\"id\":\"Q9H061\"},{\"label\":\"Transmembrane protein 186\",\"id\":\"Q96B77\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective C1GALT1C1 causes TNPS", "protein_name": "[{\"label\":\"C1GALT1-specific chaperone 1\",\"id\":\"Q96EU7\"},{\"label\":\"Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1\",\"id\":\"Q9NS00\"},{\"label\":\"Mucin-12\",\"id\":\"Q9UKN1\"},{\"label\":\"Mucin-13\",\"id\":\"Q9H3R2\"},{\"label\":\"Mucin-15\",\"id\":\"Q8N387\"},{\"label\":\"Mucin-16\",\"id\":\"Q8WXI7\"},{\"label\":\"Mucin-17\",\"id\":\"Q685J3\"},{\"label\":\"Mucin-19\",\"id\":\"Q7Z5P9\"},{\"label\":\"Mucin-1\",\"id\":\"P15941\"},{\"label\":\"Mucin-20\",\"id\":\"Q8N307\"},{\"label\":\"Mucin-21\",\"id\":\"Q5SSG8\"},{\"label\":\"Mucin-2\",\"id\":\"Q02817\"},{\"label\":\"Mucin-3A\",\"id\":\"Q02505\"},{\"label\":\"Mucin-3B\",\"id\":\"Q9H195\"},{\"label\":\"Mucin-4\",\"id\":\"Q99102\"},{\"label\":\"Mucin-5AC\",\"id\":\"P98088\"},{\"label\":\"Mucin-5B\",\"id\":\"Q9HC84\"},{\"label\":\"Mucin-6\",\"id\":\"Q6W4X9\"},{\"label\":\"Mucin-7\",\"id\":\"Q8TAX7\"},{\"label\":\"Mucin-like protein 1\",\"id\":\"Q96DR8\"}]", "uniprot_id": "[\"P15941\",\"P98088\",\"Q02505\",\"Q02817\",\"Q5SSG8\",\"Q685J3\",\"Q6W4X9\",\"Q7Z5P9\",\"Q8N307\",\"Q8N387\",\"Q8TAX7\",\"Q8WXI7\",\"Q96DR8\",\"Q96EU7\",\"Q99102\",\"Q9H195\",\"Q9H3R2\",\"Q9HC84\",\"Q9NS00\",\"Q9UKN1\"]", "gene_symbol": "[\"C1GALT1\",\"C1GALT1C1\",\"C6orf205\",\"CA125\",\"COSMC\",\"DRCC1\",\"KIAA1359\",\"MG2\",\"MUC1\",\"MUC11\",\"MUC12\",\"MUC13\",\"MUC15\",\"MUC16\",\"MUC17\",\"MUC19\",\"MUC2\",\"MUC20\",\"MUC21\",\"MUC3\",\"MUC3A\",\"MUC3B\",\"MUC4\",\"MUC5\",\"MUC5AC\",\"MUC5B\",\"MUC6\",\"MUC7\",\"MUCL1\",\"PUM\",\"RECC\",\"SBEM\",\"SMUC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Glycosphingolipid transport", "protein_name": "[{\"label\":\"ADP-ribosylation factor 1\",\"id\":\"P84077\"},{\"label\":\"Battenin\",\"id\":\"Q13286\"},{\"label\":\"Ceramide-1-phosphate transfer protein\",\"id\":\"Q5TA50\"},{\"label\":\"Extended synaptotagmin-1\",\"id\":\"Q9BSJ8\"},{\"label\":\"Extended synaptotagmin-2\",\"id\":\"A0FGR8\"},{\"label\":\"Extended synaptotagmin-3\",\"id\":\"A0FGR9\"},{\"label\":\"Glycolipid transfer protein\",\"id\":\"Q9NZD2\"},{\"label\":\"Pleckstrin homology domain-containing family A member 8\",\"id\":\"Q96JA3\"}]", "uniprot_id": "[\"A0FGR8\",\"A0FGR9\",\"P84077\",\"Q13286\",\"Q5TA50\",\"Q96JA3\",\"Q9BSJ8\",\"Q9NZD2\"]", "gene_symbol": "[\"ARF1\",\"BTS\",\"CLN3\",\"CPTP\",\"ESYT1\",\"ESYT2\",\"ESYT3\",\"FAM62A\",\"FAM62B\",\"FAM62C\",\"FAPP2\",\"GLTP\",\"GLTPD1\",\"KIAA0747\",\"KIAA1228\",\"MBC2\",\"PLEKHA8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "E3 ubiquitin ligases ubiquitinate target proteins", "protein_name": "[{\"label\":\"B-cell lymphoma/leukemia 10\",\"id\":\"O95999\"},{\"label\":\"DNA-dependent protein kinase catalytic subunit\",\"id\":\"P78527\"},{\"label\":\"Derlin-1\",\"id\":\"Q9BUN8\"},{\"label\":\"E3 ubiquitin-protein ligase BRE1A\",\"id\":\"Q5VTR2\"},{\"label\":\"E3 ubiquitin-protein ligase BRE1B\",\"id\":\"O75150\"},{\"label\":\"E3 ubiquitin-protein ligase RAD18\",\"id\":\"Q9NS91\"},{\"label\":\"E3 ubiquitin-protein ligase RNF144A\",\"id\":\"P50876\"},{\"label\":\"E3 ubiquitin-protein ligase RNF152\",\"id\":\"Q8N8N0\"},{\"label\":\"E3 ubiquitin-protein ligase RNF181\",\"id\":\"Q9P0P0\"},{\"label\":\"E3 ubiquitin-protein ligase SHPRH\",\"id\":\"Q149N8\"},{\"label\":\"E3 ubiquitin-protein ligase TM129\",\"id\":\"A0AVI4\"},{\"label\":\"HLA class I histocompatibility antigen, A alpha chain\",\"id\":\"P04439\"},{\"label\":\"Helicase-like transcription factor\",\"id\":\"Q14527\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"MHC Class I antigen (B60) (Fragment)\",\"id\":\"Q9MY60\"},{\"label\":\"Parafibromin\",\"id\":\"Q6P1J9\"},{\"label\":\"Peroxisomal membrane protein PEX13\",\"id\":\"Q92968\"},{\"label\":\"Peroxisomal membrane protein PEX14\",\"id\":\"O75381\"},{\"label\":\"Peroxisome assembly protein 12\",\"id\":\"O00623\"},{\"label\":\"Peroxisome biogenesis factor 10\",\"id\":\"O60683\"},{\"label\":\"Peroxisome biogenesis factor 2\",\"id\":\"P28328\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"RNA polymerase II-associated factor 1 homolog\",\"id\":\"Q8N7H5\"},{\"label\":\"RNA polymerase-associated protein CTR9 homolog\",\"id\":\"Q6PD62\"},{\"label\":\"RNA polymerase-associated protein LEO1\",\"id\":\"Q8WVC0\"},{\"label\":\"RNA polymerase-associated protein RTF1 homolog\",\"id\":\"Q92541\"},{\"label\":\"Ras-related GTP-binding protein A\",\"id\":\"Q7L523\"},{\"label\":\"Selenoprotein S\",\"id\":\"Q9BQE4\"},{\"label\":\"Superkiller complex protein 8\",\"id\":\"Q9GZS3\"},{\"label\":\"Transitional endoplasmic reticulum ATPase\",\"id\":\"P55072\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 A\",\"id\":\"P49459\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 B\",\"id\":\"P63146\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D2\",\"id\":\"P62837\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D3\",\"id\":\"P61077\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 J2\",\"id\":\"Q8N2K1\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 L3\",\"id\":\"P68036\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 2\",\"id\":\"Q15819\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Unique short US11 glycoprotein\",\"id\":\"P09727\"},{\"label\":\"WW domain-containing adapter protein with coiled-coil\",\"id\":\"Q9BTA9\"}]", "uniprot_id": "[\"A0AVI4\",\"O00623\",\"O60683\",\"O60814\",\"O75150\",\"O75381\",\"O95999\",\"P04439\",\"P06899\",\"P09727\",\"P0CG47\",\"P0CG48\",\"P12004\",\"P23527\",\"P28328\",\"P33778\",\"P49459\",\"P50876\",\"P51668\",\"P51965\",\"P55072\",\"P58876\",\"P61077\",\"P61088\",\"P62807\",\"P62837\",\"P62979\",\"P62987\",\"P63146\",\"P68036\",\"P78527\",\"Q14527\",\"Q149N8\",\"Q15819\",\"Q5VTR2\",\"Q6P1J9\",\"Q6PD62\",\"Q7L523\",\"Q8N2K1\",\"Q8N7H5\",\"Q8N8N0\",\"Q8WVC0\",\"Q92541\",\"Q92968\",\"Q93079\",\"Q96A08\",\"Q99877\",\"Q99879\",\"Q99880\",\"Q9BQE4\",\"Q9BTA9\",\"Q9BUN8\",\"Q9GZS3\",\"Q9MY60\",\"Q9NS91\",\"Q9P0P0\"]", "gene_symbol": "[\"BCL10\",\"BLU\",\"BRE1A\",\"BRE1B\",\"C1orf28\",\"CDC73\",\"CIPER\",\"CLAP\",\"CTR9\",\"DER1\",\"DERL1\",\"H2BC1\",\"H2BC10\",\"H2BC11\",\"H2BC12\",\"H2BC13\",\"H2BC14\",\"H2BC15\",\"H2BC17\",\"H2BC3\",\"H2BC4\",\"H2BC5\",\"H2BC6\",\"H2BC7\",\"H2BC8\",\"H2BC9\",\"H2BFA\",\"H2BFB\",\"H2BFC\",\"H2BFD\",\"H2BFE\",\"H2BFF\",\"H2BFG\",\"H2BFH\",\"H2BFJ\",\"H2BFK\",\"H2BFL\",\"H2BFN\",\"H2BFR\",\"H2BFT\",\"HEL-220\",\"HEL-S-70\",\"HIP116A\",\"HIRIP1\",\"HIRIP2\",\"HIST1H2BA\",\"HIST1H2BB\",\"HIST1H2BC\",\"HIST1H2BD\",\"HIST1H2BE\",\"HIST1H2BF\",\"HIST1H2BG\",\"HIST1H2BH\",\"HIST1H2BI\",\"HIST1H2BJ\",\"HIST1H2BK\",\"HIST1H2BL\",\"HIST1H2BM\",\"HIST1H2BN\",\"HIST1H2BO\",\"HLA-A\",\"HLA-B\",\"HLAA\",\"HLTF\",\"HRPT2\",\"HYRC\",\"HYRC1\",\"KIAA0155\",\"KIAA0161\",\"KIAA0252\",\"KIAA0661\",\"KIAA1844\",\"KIAA2023\",\"LEO1\",\"MMS2\",\"NCUBE2\",\"PAF1\",\"PAF3\",\"PCNA\",\"PD2\",\"PEX10\",\"PEX12\",\"PEX13\",\"PEX14\",\"PEX2\",\"PMP3\",\"PMP35\",\"PRKDC\",\"PUBC1\",\"PXMP3\",\"RAD18\",\"RAD6A\",\"RAD6B\",\"RDL\",\"RNF144\",\"RNF144A\",\"RNF152\",\"RNF181\",\"RNF20\",\"RNF40\",\"RNF69\",\"RNF72\",\"RNF73\",\"RNF80\",\"RPS27A\",\"RRAGA\",\"RTF1\",\"SELENOS\",\"SELS\",\"SFT\",\"SH2BP1\",\"SHPRH\",\"SKIC8\",\"SMARCA3\",\"SNF2L3\",\"TMEM129\",\"TSH2B\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBC4\",\"UBC5A\",\"UBC5B\",\"UBC5C\",\"UBCE7\",\"UBCE7IP4\",\"UBCEP1\",\"UBCEP2\",\"UBCH1\",\"UBCH4\",\"UBCH5\",\"UBCH5A\",\"UBCH5B\",\"UBCH5C\",\"UBCH6\",\"UBCH7\",\"UBE2A\",\"UBE2B\",\"UBE2D1\",\"UBE2D2\",\"UBE2D3\",\"UBE2E1\",\"UBE2J2\",\"UBE2L3\",\"UBE2N\",\"UBE2V2\",\"UEV2\",\"US11\",\"VCP\",\"VIMP\",\"WAC\",\"WDR61\",\"ZBU1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of editosomes by ADAR proteins", "protein_name": "[{\"label\":\"Double-stranded RNA-specific adenosine deaminase\",\"id\":\"P55265\"},{\"label\":\"Double-stranded RNA-specific editase 1\",\"id\":\"P78563\"}]", "uniprot_id": "[\"P55265\",\"P78563\"]", "gene_symbol": "[\"ADAR\",\"ADAR1\",\"ADAR2\",\"ADARB1\",\"DRADA2\",\"DSRAD\",\"G1P1\",\"IFI4\",\"RED1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA", "protein_name": "[{\"label\":\"Insulin-like growth factor 2 mRNA-binding protein 1\",\"id\":\"Q9NZI8\"},{\"label\":\"Insulin-like growth factor 2 mRNA-binding protein 2\",\"id\":\"Q9Y6M1\"},{\"label\":\"Insulin-like growth factor 2 mRNA-binding protein 3\",\"id\":\"O00425\"}]", "uniprot_id": "[\"O00425\",\"Q9NZI8\",\"Q9Y6M1\"]", "gene_symbol": "[\"CRDBP\",\"IGF2BP1\",\"IGF2BP2\",\"IGF2BP3\",\"IMP2\",\"IMP3\",\"KOC1\",\"VICKZ1\",\"VICKZ2\",\"VICKZ3\",\"ZBP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "U12 Dependent Splicing", "protein_name": "[{\"label\":\"116 kDa U5 small nuclear ribonucleoprotein component\",\"id\":\"Q15029\"},{\"label\":\"ATP-dependent RNA helicase DDX42\",\"id\":\"Q86XP3\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit 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region-containing protein 3\",\"id\":\"Q96LT9\"},{\"label\":\"Serine/arginine-rich splicing factor 1\",\"id\":\"Q07955\"},{\"label\":\"Serine/arginine-rich splicing factor 2\",\"id\":\"Q01130\"},{\"label\":\"Serine/arginine-rich splicing factor 6\",\"id\":\"Q13247\"},{\"label\":\"Serine/arginine-rich splicing factor 7\",\"id\":\"Q16629\"},{\"label\":\"Small nuclear ribonucleoprotein E\",\"id\":\"P62304\"},{\"label\":\"Small nuclear ribonucleoprotein F\",\"id\":\"P62306\"},{\"label\":\"Small nuclear ribonucleoprotein G\",\"id\":\"P62308\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D1\",\"id\":\"P62314\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D2\",\"id\":\"P62316\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D3\",\"id\":\"P62318\"},{\"label\":\"Small nuclear ribonucleoprotein-associated proteins B and B'\",\"id\":\"P14678\"},{\"label\":\"Splicing factor 3B subunit 1\",\"id\":\"O75533\"},{\"label\":\"Splicing factor 3B subunit 2\",\"id\":\"Q13435\"},{\"label\":\"Splicing factor 3B subunit 3\",\"id\":\"Q15393\"},{\"label\":\"Splicing factor 3B subunit 4\",\"id\":\"Q15427\"},{\"label\":\"Splicing factor 3B subunit 5\",\"id\":\"Q9BWJ5\"},{\"label\":\"Splicing factor 3B subunit 6\",\"id\":\"Q9Y3B4\"},{\"label\":\"Thioredoxin-like protein 4A\",\"id\":\"P83876\"},{\"label\":\"U11/U12 small nuclear ribonucleoprotein 25 kDa protein\",\"id\":\"Q9BV90\"},{\"label\":\"U11/U12 small nuclear ribonucleoprotein 35 kDa protein\",\"id\":\"Q16560\"},{\"label\":\"U11/U12 small nuclear ribonucleoprotein 48 kDa protein\",\"id\":\"Q6IEG0\"},{\"label\":\"U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2\",\"id\":\"Q15696\"},{\"label\":\"U5 small nuclear ribonucleoprotein 200 kDa helicase\",\"id\":\"O75643\"},{\"label\":\"U5 small nuclear ribonucleoprotein 40 kDa protein\",\"id\":\"Q96DI7\"},{\"label\":\"Y-box-binding protein 1\",\"id\":\"P67809\"},{\"label\":\"Zinc finger CCHC-type and RNA-binding motif-containing protein 1\",\"id\":\"Q8TBF4\"},{\"label\":\"Zinc finger matrin-type protein 5\",\"id\":\"Q9UDW3\"}]", "uniprot_id": "[\"O15514\",\"O75533\",\"O75643\",\"O94906\",\"P13984\",\"P14678\",\"P19387\",\"P19388\",\"P24928\",\"P30876\",\"P35269\",\"P36954\",\"P52298\",\"P52434\",\"P52435\",\"P53803\",\"P61218\",\"P62304\",\"P62306\",\"P62308\",\"P62314\",\"P62316\",\"P62318\",\"P62487\",\"P62875\",\"P67809\",\"P83876\",\"Q01130\",\"Q07955\",\"Q09161\",\"Q13247\",\"Q13435\",\"Q15029\",\"Q15393\",\"Q15427\",\"Q15696\",\"Q16560\",\"Q16629\",\"Q6IEG0\",\"Q6P2Q9\",\"Q86XP3\",\"Q8N8D1\",\"Q8TBF4\",\"Q96DI7\",\"Q96LT9\",\"Q9BUQ8\",\"Q9BV90\",\"Q9BWJ5\",\"Q9UDW3\",\"Q9Y3B4\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by MAPK mutants", "protein_name": "[{\"label\":\"Dual specificity protein phosphatase 10\",\"id\":\"Q9Y6W6\"},{\"label\":\"Dual specificity protein phosphatase 16\",\"id\":\"Q9BY84\"},{\"label\":\"Dual specificity protein phosphatase 6\",\"id\":\"Q16828\"},{\"label\":\"Dual specificity protein phosphatase 7\",\"id\":\"Q16829\"},{\"label\":\"Dual specificity protein phosphatase 8\",\"id\":\"Q13202\"},{\"label\":\"Dual specificity protein phosphatase 9\",\"id\":\"Q99956\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"}]", "uniprot_id": "[\"P28482\",\"Q13202\",\"Q16828\",\"Q16829\",\"Q99956\",\"Q9BY84\",\"Q9Y6W6\"]", "gene_symbol": "[\"C11orf81\",\"DUSP10\",\"DUSP16\",\"DUSP6\",\"DUSP7\",\"DUSP8\",\"DUSP9\",\"ERK2\",\"KIAA1700\",\"MAPK1\",\"MKP3\",\"MKP4\",\"MKP5\",\"MKP7\",\"PRKM1\",\"PRKM2\",\"PYST1\",\"PYST2\",\"VH5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of pyrophosphates in the cytosol", "protein_name": "[{\"label\":\"Diphosphoinositol polyphosphate phosphohydrolase 1\",\"id\":\"O95989\"},{\"label\":\"Diphosphoinositol polyphosphate phosphohydrolase 2\",\"id\":\"Q9NZJ9\"},{\"label\":\"Diphosphoinositol polyphosphate phosphohydrolase 3-alpha\",\"id\":\"Q8NFP7\"},{\"label\":\"Diphosphoinositol polyphosphate phosphohydrolase 3-beta\",\"id\":\"Q96G61\"},{\"label\":\"Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1\",\"id\":\"Q6PFW1\"},{\"label\":\"Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2\",\"id\":\"O43314\"},{\"label\":\"Inositol hexakisphosphate kinase 1\",\"id\":\"Q92551\"},{\"label\":\"Inositol hexakisphosphate kinase 3\",\"id\":\"Q96PC2\"},{\"label\":\"Inositol-pentakisphosphate 2-kinase\",\"id\":\"Q9H8X2\"},{\"label\":\"Inositol-tetrakisphosphate 1-kinase\",\"id\":\"Q13572\"}]", "uniprot_id": "[\"O43314\",\"O95989\",\"Q13572\",\"Q6PFW1\",\"Q8NFP7\",\"Q92551\",\"Q96G61\",\"Q96PC2\",\"Q9H8X2\",\"Q9NZJ9\"]", "gene_symbol": "[\"APS1\",\"APS2\",\"C9orf12\",\"DIPP\",\"DIPP1\",\"DIPP2\",\"DIPP3A\",\"DIPP3B\",\"HISPPD1\",\"HISPPD2A\",\"IHPK1\",\"IHPK3\",\"IP6K\",\"IP6K1\",\"IP6K3\",\"IPPK\",\"IPS1\",\"ITPK1\",\"KIAA0263\",\"KIAA0377\",\"KIAA0433\",\"KIAA0487\",\"NUDT10\",\"NUDT11\",\"NUDT3\",\"NUDT4\",\"PPIP5K1\",\"PPIP5K2\",\"VIP1\",\"VIP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Inhibition of Signaling by Overexpressed EGFR", "protein_name": "[{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Epigen\",\"id\":\"Q6UW88\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Protransforming growth factor alpha\",\"id\":\"P01135\"}]", "uniprot_id": 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isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": "[\"O60825\",\"P16118\",\"P17612\",\"P22612\",\"P22694\",\"P30153\",\"P30154\",\"P62714\",\"P67775\",\"Q14738\",\"Q16875\",\"Q16877\"]", "gene_symbol": "[\"F6PK\",\"PFKFB1\",\"PFKFB2\",\"PFKFB3\",\"PFKFB4\",\"PFRX\",\"PKACA\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5D\",\"PRKACA\",\"PRKACB\",\"PRKACG\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Negative regulation of MET activity", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Endophilin-A1\",\"id\":\"Q99962\"},{\"label\":\"Endophilin-A2\",\"id\":\"Q99961\"},{\"label\":\"Endophilin-A3\",\"id\":\"Q99963\"},{\"label\":\"Epidermal growth factor receptor substrate 15\",\"id\":\"P42566\"},{\"label\":\"Hepatocyte growth factor receptor\",\"id\":\"P08581\"},{\"label\":\"Hepatocyte growth factor-regulated tyrosine kinase substrate\",\"id\":\"O14964\"},{\"label\":\"Hepatocyte growth factor\",\"id\":\"P14210\"},{\"label\":\"Leucine-rich repeats and immunoglobulin-like domains protein 1\",\"id\":\"Q96JA1\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase eta\",\"id\":\"Q12913\"},{\"label\":\"SH3 domain-containing kinase-binding protein 1\",\"id\":\"Q96B97\"},{\"label\":\"Signal transducing adapter molecule 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TRIM48\",\"id\":\"Q8IWZ4\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM62\",\"id\":\"Q9BVG3\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM68\",\"id\":\"Q6AZZ1\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM8\",\"id\":\"Q9BZR9\"},{\"label\":\"E3 ubiquitin/ISG15 ligase TRIM25\",\"id\":\"Q14258\"},{\"label\":\"Gamma-interferon-inducible lysosomal thiol reductase\",\"id\":\"P13284\"},{\"label\":\"Guanylate-binding protein 1\",\"id\":\"P32455\"},{\"label\":\"Guanylate-binding protein 2\",\"id\":\"P32456\"},{\"label\":\"Guanylate-binding protein 3\",\"id\":\"Q9H0R5\"},{\"label\":\"Guanylate-binding protein 4\",\"id\":\"Q96PP9\"},{\"label\":\"Guanylate-binding protein 5\",\"id\":\"Q96PP8\"},{\"label\":\"Guanylate-binding protein 6\",\"id\":\"Q6ZN66\"},{\"label\":\"Guanylate-binding protein 7\",\"id\":\"Q8N8V2\"},{\"label\":\"HLA class I histocompatibility antigen, A alpha chain\",\"id\":\"P04439\"},{\"label\":\"HLA class I histocompatibility antigen, B alpha 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2\",\"id\":\"O00763\"},{\"label\":\"Biotin--protein ligase\",\"id\":\"P50747\"},{\"label\":\"Biotinidase\",\"id\":\"P43251\"},{\"label\":\"Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial\",\"id\":\"Q9HCC0\"},{\"label\":\"Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial\",\"id\":\"Q96RQ3\"},{\"label\":\"PDZ domain-containing protein 11\",\"id\":\"Q5EBL8\"},{\"label\":\"Propionyl-CoA carboxylase alpha chain, mitochondrial\",\"id\":\"P05165\"},{\"label\":\"Propionyl-CoA carboxylase beta chain, mitochondrial\",\"id\":\"P05166\"},{\"label\":\"Pyruvate carboxylase, mitochondrial\",\"id\":\"P11498\"},{\"label\":\"Sodium-dependent multivitamin transporter\",\"id\":\"Q9Y289\"}]", "uniprot_id": "[\"O00763\",\"P05165\",\"P05166\",\"P11498\",\"P43251\",\"P50747\",\"Q13085\",\"Q5EBL8\",\"Q96RQ3\",\"Q9HCC0\",\"Q9Y289\"]", "gene_symbol": 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homolog\",\"id\":\"Q9Y547\"},{\"label\":\"Intraflagellar transport protein 27 homolog\",\"id\":\"Q9BW83\"},{\"label\":\"Intraflagellar transport protein 43 homolog\",\"id\":\"Q96FT9\"},{\"label\":\"Intraflagellar transport protein 46 homolog\",\"id\":\"Q9NQC8\"},{\"label\":\"Intraflagellar transport protein 52 homolog\",\"id\":\"Q9Y366\"},{\"label\":\"Intraflagellar transport protein 56\",\"id\":\"A0AVF1\"},{\"label\":\"Intraflagellar transport protein 57 homolog\",\"id\":\"Q9NWB7\"},{\"label\":\"Intraflagellar transport protein 70A\",\"id\":\"Q86WT1\"},{\"label\":\"Intraflagellar transport protein 70B\",\"id\":\"Q8N4P2\"},{\"label\":\"Intraflagellar transport protein 74 homolog\",\"id\":\"Q96LB3\"},{\"label\":\"Intraflagellar transport protein 80 homolog\",\"id\":\"Q9P2H3\"},{\"label\":\"Intraflagellar transport protein 81 homolog\",\"id\":\"Q8WYA0\"},{\"label\":\"Intraflagellar transport protein 88 homolog\",\"id\":\"Q13099\"},{\"label\":\"Kinesin-associated protein 3\",\"id\":\"Q92845\"},{\"label\":\"Kinesin-like protein KIF17\",\"id\":\"Q9P2E2\"},{\"label\":\"Kinesin-like protein KIF3A\",\"id\":\"Q9Y496\"},{\"label\":\"Kinesin-like protein KIF3B\",\"id\":\"O15066\"},{\"label\":\"Kinesin-like protein KIF3C\",\"id\":\"O14782\"},{\"label\":\"TRAF3-interacting protein 1\",\"id\":\"Q8TDR0\"},{\"label\":\"Tetratricopeptide repeat protein 21B\",\"id\":\"Q7Z4L5\"},{\"label\":\"Thyroid receptor-interacting protein 11\",\"id\":\"Q15643\"},{\"label\":\"Transportin-1\",\"id\":\"Q92973\"},{\"label\":\"WD repeat-containing protein 19\",\"id\":\"Q8NEZ3\"},{\"label\":\"WD repeat-containing protein 35\",\"id\":\"Q9P2L0\"}]", "uniprot_id": 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23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 4\",\"id\":\"P22455\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Fibroblast growth factor receptor substrate 3\",\"id\":\"O43559\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O43320\",\"O43559\",\"O76093\",\"O95750\",\"P01111\",\"P01112\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P22455\",\"P31371\",\"Q06124\",\"Q07889\",\"Q86Z14\",\"Q8WU20\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": 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2A13\",\"id\":\"Q16696\"},{\"label\":\"Cytochrome P450 3A4\",\"id\":\"P08684\"},{\"label\":\"Cytochrome P450 3A5\",\"id\":\"P20815\"},{\"label\":\"Dipeptidase 1\",\"id\":\"P16444\"},{\"label\":\"Dipeptidase 2\",\"id\":\"Q9H4A9\"},{\"label\":\"Glutathione S-transferase 3, mitochondrial\",\"id\":\"O14880\"},{\"label\":\"Glutathione hydrolase 1 proenzyme\",\"id\":\"P19440\"},{\"label\":\"Glutathione hydrolase 5 proenzyme\",\"id\":\"P36269\"},{\"label\":\"Glutathione hydrolase 6\",\"id\":\"Q6P531\"},{\"label\":\"Glutathione hydrolase 7\",\"id\":\"Q9UJ14\"},{\"label\":\"Microsomal glutathione S-transferase 1\",\"id\":\"P10620\"},{\"label\":\"Microsomal glutathione S-transferase 2\",\"id\":\"Q99735\"},{\"label\":\"N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)\",\"id\":\"Q96HD9\"},{\"label\":\"Putative glutathione hydrolase 3 proenzyme\",\"id\":\"A6NGU5\"}]", "uniprot_id": 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receptor\",\"id\":\"P40238\"},{\"label\":\"Thrombopoietin\",\"id\":\"P40225\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"P00734\",\"P04275\",\"P07359\",\"P13224\",\"P14770\",\"P40197\",\"P40225\",\"P40238\"]", "gene_symbol": "[\"F2\",\"F8VWF\",\"GP1BA\",\"GP1BB\",\"GP5\",\"GP9\",\"MGDF\",\"MPL\",\"THPO\",\"TPOR\",\"VWF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of BACH1 activity", "protein_name": "[{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"F-box/LRR-repeat protein 17\",\"id\":\"Q9UF56\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"S-phase kinase-associated protein 2\",\"id\":\"Q13309\"},{\"label\":\"Transcription factor MafK\",\"id\":\"O60675\"},{\"label\":\"Transcription regulator protein 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2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 3-20\",\"id\":\"P01619\"},{\"label\":\"Immunoglobulin kappa variable 3D-20\",\"id\":\"A0A0C4DH25\"},{\"label\":\"Immunoglobulin kappa variable 4-1\",\"id\":\"P06312\"},{\"label\":\"Immunoglobulin kappa variable 5-2\",\"id\":\"P06315\"},{\"label\":\"Immunoglobulin lambda constant 1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 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myosin-Va\",\"id\":\"Q9Y4I1\"},{\"label\":\"Unconventional myosin-X\",\"id\":\"Q9HD67\"},{\"label\":\"V1-11 protein (Fragment)\",\"id\":\"Q5NV67\"},{\"label\":\"V1-13 protein (Fragment)\",\"id\":\"Q5NV69\"},{\"label\":\"V1-16 protein (Fragment)\",\"id\":\"Q5NV81\"},{\"label\":\"V1-20 protein (Fragment)\",\"id\":\"Q5NV86\"},{\"label\":\"V1-3 protein (Fragment)\",\"id\":\"Q5NV84\"},{\"label\":\"V1-5 protein (Fragment)\",\"id\":\"Q5NV65\"},{\"label\":\"V1-7 protein (Fragment)\",\"id\":\"Q5NV89\"},{\"label\":\"V1-9 protein (Fragment)\",\"id\":\"Q5NV66\"},{\"label\":\"V2-11 protein (Fragment)\",\"id\":\"Q5NV64\"},{\"label\":\"V2-15 protein (Fragment)\",\"id\":\"Q5NV75\"},{\"label\":\"V2-17 protein (Fragment)\",\"id\":\"Q5NV90\"},{\"label\":\"V2-19 protein (Fragment)\",\"id\":\"Q5NV91\"},{\"label\":\"V2-8 protein (Fragment)\",\"id\":\"Q5NV85\"},{\"label\":\"V3-2 protein (Fragment)\",\"id\":\"Q5NV80\"},{\"label\":\"V3-3 protein (Fragment)\",\"id\":\"Q5NV83\"},{\"label\":\"V3-4 protein (Fragment)\",\"id\":\"Q5NV62\"},{\"label\":\"V4-1 protein (Fragment)\",\"id\":\"Q5NV68\"},{\"label\":\"V4-2 protein (Fragment)\",\"id\":\"Q5NV82\"},{\"label\":\"V4-6 protein (Fragment)\",\"id\":\"Q5NV87\"},{\"label\":\"V5-1 protein (Fragment)\",\"id\":\"Q5NV61\"},{\"label\":\"V5-4 protein (Fragment)\",\"id\":\"Q5NV79\"},{\"label\":\"V5-6 protein (Fragment)\",\"id\":\"Q5NV92\"},{\"label\":\"WAS/WASL-interacting protein family member 1\",\"id\":\"O43516\"},{\"label\":\"WAS/WASL-interacting protein family member 2\",\"id\":\"Q8TF74\"},{\"label\":\"WAS/WASL-interacting protein family member 3\",\"id\":\"A6NGB9\"}]", "uniprot_id": 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isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"P30153\",\"P30154\",\"P62714\",\"P67775\",\"Q14738\"]", "gene_symbol": "[\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5D\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TGFBR2 MSI Frameshift Mutants in Cancer", "protein_name": "[{\"label\":\"TGF-beta receptor type-2\",\"id\":\"P37173\"},{\"label\":\"Transforming growth factor beta-1 proprotein\",\"id\":\"P01137\"}]", "uniprot_id": "[\"P01137\",\"P37173\"]", "gene_symbol": "[\"TGFB\",\"TGFB1\",\"TGFBR2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Abacavir metabolism", "protein_name": "[{\"label\":\"Adenosine deaminase-like protein\",\"id\":\"Q6DHV7\"},{\"label\":\"Alcohol dehydrogenase 1A\",\"id\":\"P07327\"},{\"label\":\"Cytosolic purine 5'-nucleotidase\",\"id\":\"P49902\"},{\"label\":\"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]\",\"id\":\"P35558\"}]", "uniprot_id": "[\"P07327\",\"P35558\",\"P49902\",\"Q6DHV7\"]", "gene_symbol": "[\"ADAL\",\"ADAL1\",\"ADH1\",\"ADH1A\",\"NT5B\",\"NT5C2\",\"NT5CP\",\"PCK1\",\"PEPCK1\",\"PNT5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of the apoptosome activity", "protein_name": "[{\"label\":\"Apoptotic protease-activating factor 1\",\"id\":\"O14727\"},{\"label\":\"Caspase recruitment domain-containing protein 8\",\"id\":\"Q9Y2G2\"},{\"label\":\"Caspase-9\",\"id\":\"P55211\"},{\"label\":\"Cell death regulator Aven\",\"id\":\"Q9NQS1\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"Diablo IAP-binding mitochondrial protein\",\"id\":\"Q9NR28\"},{\"label\":\"E3 ubiquitin-protein ligase XIAP\",\"id\":\"P98170\"},{\"label\":\"Methylthioribulose-1-phosphate dehydratase\",\"id\":\"Q96GX9\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Uveal autoantigen with coiled-coil domains and ankyrin repeats\",\"id\":\"Q9BZF9\"}]", "uniprot_id": "[\"O14727\",\"P27361\",\"P28482\",\"P55211\",\"P98170\",\"P99999\",\"Q96GX9\",\"Q9BZF9\",\"Q9NQS1\",\"Q9NR28\",\"Q9Y2G2\"]", "gene_symbol": "[\"APAF1\",\"API3\",\"APIP\",\"AVEN\",\"BIRC4\",\"CARD8\",\"CASP9\",\"CYC\",\"CYCS\",\"DACAR\",\"DIABLO\",\"ERK1\",\"ERK2\",\"IAP3\",\"KIAA0413\",\"KIAA0955\",\"KIAA1561\",\"MAPK1\",\"MAPK3\",\"MCH6\",\"NDPP1\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"SMAC\",\"UACA\",\"XIAP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TAK1-dependent IKK and NF-kappa-B activation", "protein_name": "[{\"label\":\"Advanced glycosylation end product-specific receptor\",\"id\":\"Q15109\"},{\"label\":\"Alpha-protein kinase 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1\",\"id\":\"Q6ZNC8\"},{\"label\":\"Lysophospholipid acyltransferase 2\",\"id\":\"Q6ZWT7\"},{\"label\":\"Lysophospholipid acyltransferase 5\",\"id\":\"Q6P1A2\"},{\"label\":\"Lysophospholipid acyltransferase LPCAT4\",\"id\":\"Q643R3\"},{\"label\":\"Phospholipase A and acyltransferase 1\",\"id\":\"Q9HDD0\"},{\"label\":\"Phospholipase A and acyltransferase 2\",\"id\":\"Q9NWW9\"},{\"label\":\"Phospholipase A and acyltransferase 3\",\"id\":\"P53816\"},{\"label\":\"Phospholipase A and acyltransferase 4\",\"id\":\"Q9UL19\"},{\"label\":\"Phospholipase A and acyltransferase 5\",\"id\":\"Q96KN8\"},{\"label\":\"Phospholipase A2 group V\",\"id\":\"P39877\"},{\"label\":\"Phospholipase A2, membrane associated\",\"id\":\"P14555\"},{\"label\":\"Phospholipase A2\",\"id\":\"P04054\"},{\"label\":\"Phospholipase B-like 1\",\"id\":\"Q6P4A8\"},{\"label\":\"Secretory phospholipase A2 receptor\",\"id\":\"Q13018\"}]", "uniprot_id": 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"[\"ABHD4\",\"AGPAT7\",\"AYTL3\",\"CLEC13C\",\"CPLA2\",\"HRASLS\",\"HRASLS2\",\"HRASLS3\",\"HRASLS5\",\"HREV107\",\"HRLP5\",\"IPLA22\",\"IPLA2G\",\"LPCAT3\",\"LPCAT4\",\"LPEAT2\",\"MBOAT1\",\"MBOAT2\",\"MBOAT5\",\"OACT1\",\"OACT2\",\"OACT5\",\"PLA2\",\"PLA2A\",\"PLA2B\",\"PLA2G10\",\"PLA2G12\",\"PLA2G12A\",\"PLA2G16\",\"PLA2G1B\",\"PLA2G2A\",\"PLA2G2D\",\"PLA2G2E\",\"PLA2G2F\",\"PLA2G3\",\"PLA2G4\",\"PLA2G4A\",\"PLA2G4B\",\"PLA2G4C\",\"PLA2G4D\",\"PLA2G4E\",\"PLA2G4F\",\"PLA2G5\",\"PLA2G6\",\"PLA2L\",\"PLA2R1\",\"PLAAT1\",\"PLAAT2\",\"PLAAT3\",\"PLAAT4\",\"PLAAT5\",\"PLBD1\",\"PLPLA9\",\"PNPLA8\",\"PPLA2\",\"RARRES3\",\"RASF-A\",\"RIG1\",\"SPLASH\",\"TIG3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Post-transcriptional silencing by small RNAs", "protein_name": "[{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"}]", "uniprot_id": "[\"Q8NDV7\",\"Q9H9G7\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9UPQ9\"]", "gene_symbol": "[\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"CAGH26\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HDL remodeling", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family G member 1\",\"id\":\"P45844\"},{\"label\":\"Albumin\",\"id\":\"P02768\"},{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Apolipoprotein C-II\",\"id\":\"P02655\"},{\"label\":\"Apolipoprotein C-III\",\"id\":\"P02656\"},{\"label\":\"Apolipoprotein E\",\"id\":\"P02649\"},{\"label\":\"Cholesteryl ester transfer protein\",\"id\":\"P11597\"},{\"label\":\"Endothelial lipase\",\"id\":\"Q9Y5X9\"},{\"label\":\"Phosphatidylcholine-sterol acyltransferase\",\"id\":\"P04180\"}]", "uniprot_id": "[\"P02647\",\"P02649\",\"P02655\",\"P02656\",\"P02768\",\"P04180\",\"P11597\",\"P45844\",\"Q9Y5X9\"]", "gene_symbol": "[\"ABC8\",\"ABCG1\",\"ALB\",\"APC2\",\"APOA1\",\"APOC2\",\"APOC3\",\"APOE\",\"CETP\",\"LCAT\",\"LIPG\",\"WHT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)", "protein_name": "[{\"label\":\"Sodium/hydrogen exchanger 6\",\"id\":\"Q92581\"}]", "uniprot_id": "[\"Q92581\"]", "gene_symbol": "[\"KIAA0267\",\"NHE6\",\"SLC9A6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Telomere C-strand synthesis initiation", "protein_name": "[{\"label\":\"Adrenocortical dysplasia protein homolog\",\"id\":\"Q96AP0\"},{\"label\":\"CST complex subunit CTC1\",\"id\":\"Q2NKJ3\"},{\"label\":\"CST complex subunit STN1\",\"id\":\"Q9H668\"},{\"label\":\"CST complex subunit TEN1\",\"id\":\"Q86WV5\"},{\"label\":\"DNA polymerase alpha catalytic subunit\",\"id\":\"P09884\"},{\"label\":\"DNA polymerase alpha subunit B\",\"id\":\"Q14181\"},{\"label\":\"DNA primase large subunit\",\"id\":\"P49643\"},{\"label\":\"DNA primase small subunit\",\"id\":\"P49642\"},{\"label\":\"Protection of telomeres protein 1\",\"id\":\"Q9NUX5\"},{\"label\":\"TERF1-interacting nuclear factor 2\",\"id\":\"Q9BSI4\"},{\"label\":\"Telomeric repeat-binding factor 1\",\"id\":\"P54274\"},{\"label\":\"Telomeric repeat-binding factor 2-interacting protein 1\",\"id\":\"Q9NYB0\"},{\"label\":\"Telomeric repeat-binding factor 2\",\"id\":\"Q15554\"}]", "uniprot_id": "[\"P09884\",\"P49642\",\"P49643\",\"P54274\",\"Q14181\",\"Q15554\",\"Q2NKJ3\",\"Q86WV5\",\"Q96AP0\",\"Q9BSI4\",\"Q9H668\",\"Q9NUX5\",\"Q9NYB0\"]", "gene_symbol": "[\"ACD\",\"C17orf106\",\"C17orf68\",\"CTC1\",\"DRIP5\",\"OBFC1\",\"PIN2\",\"PIP1\",\"POLA\",\"POLA1\",\"POLA2\",\"POT1\",\"PRIM1\",\"PRIM2\",\"PRIM2A\",\"PTOP\",\"RAP1\",\"STN1\",\"TEN1\",\"TERF1\",\"TERF2\",\"TERF2IP\",\"TIN2\",\"TINF2\",\"TINT1\",\"TPP1\",\"TRBF1\",\"TRBF2\",\"TRF\",\"TRF1\",\"TRF2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PRPP biosynthesis", "protein_name": "[{\"label\":\"Ribose-phosphate pyrophosphokinase 1\",\"id\":\"P60891\"},{\"label\":\"Ribose-phosphate pyrophosphokinase 2\",\"id\":\"P11908\"},{\"label\":\"Ribose-phosphate pyrophosphokinase 3\",\"id\":\"P21108\"}]", "uniprot_id": "[\"P11908\",\"P21108\",\"P60891\"]", "gene_symbol": "[\"PRPS1\",\"PRPS1L1\",\"PRPS2\",\"PRPS3\",\"PRPSL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC6A2 causes orthostatic intolerance (OI)", "protein_name": "[{\"label\":\"Sodium-dependent noradrenaline transporter\",\"id\":\"P23975\"}]", "uniprot_id": "[\"P23975\"]", "gene_symbol": "[\"NAT1\",\"NET1\",\"SLC6A2\",\"SLC6A5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "DAP12 signaling", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2\",\"id\":\"P16885\"},{\"label\":\"Beta-2-microglobulin\",\"id\":\"P61769\"},{\"label\":\"GRB2-related adapter protein 2\",\"id\":\"O75791\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Guanine nucleotide exchange factor VAV3\",\"id\":\"Q9UKW4\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain E\",\"id\":\"P13747\"},{\"label\":\"Lymphocyte cytosolic protein 2\",\"id\":\"Q13094\"},{\"label\":\"NKG2-C type II integral membrane protein\",\"id\":\"P26717\"},{\"label\":\"NKG2-D type II integral membrane protein\",\"id\":\"P26718\"},{\"label\":\"Natural killer cells antigen CD94\",\"id\":\"Q13241\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"TYRO protein tyrosine kinase-binding protein\",\"id\":\"O43914\"},{\"label\":\"Triggering receptor expressed on myeloid cells 2\",\"id\":\"Q9NZC2\"},{\"label\":\"Tyrosine-protein kinase BTK\",\"id\":\"Q06187\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein kinase SYK\",\"id\":\"P43405\"}]", "uniprot_id": "[\"O00459\",\"O43914\",\"O75791\",\"P01111\",\"P01112\",\"P06239\",\"P06241\",\"P13747\",\"P16885\",\"P19174\",\"P26717\",\"P26718\",\"P27986\",\"P42336\",\"P42338\",\"P43405\",\"P52735\",\"P61769\",\"P63000\",\"Q06187\",\"Q07889\",\"Q13094\",\"Q13241\",\"Q9NZC2\",\"Q9UKW4\"]", "gene_symbol": "[\"AGMX1\",\"ATK\",\"B2M\",\"BPK\",\"BTK\",\"CD94\",\"D12S2489E\",\"DAP12\",\"FYN\",\"GADS\",\"GRAP2\",\"GRB1\",\"GRB2L\",\"GRID\",\"HLA-6.2\",\"HLA-E\",\"HLAE\",\"HRAS\",\"HRAS1\",\"KARAP\",\"KLRC2\",\"KLRD1\",\"KLRK1\",\"LCK\",\"LCP2\",\"NKG2C\",\"NKG2D\",\"NRAS\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3R1\",\"PIK3R2\",\"PLC1\",\"PLCG1\",\"PLCG2\",\"RAC1\",\"SOS1\",\"SYK\",\"TC25\",\"TREM2\",\"TYROBP\",\"VAV2\",\"VAV3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Peptide ligand-binding receptors", "protein_name": "[{\"label\":\"Adrenocorticotropic hormone receptor\",\"id\":\"Q01718\"},{\"label\":\"Angiotensinogen\",\"id\":\"P01019\"},{\"label\":\"Apelin receptor\",\"id\":\"P35414\"},{\"label\":\"Apelin\",\"id\":\"Q9ULZ1\"},{\"label\":\"Atypical chemokine receptor 1\",\"id\":\"Q16570\"},{\"label\":\"B1 bradykinin receptor\",\"id\":\"P46663\"},{\"label\":\"B2 bradykinin receptor\",\"id\":\"P30411\"},{\"label\":\"Bombesin receptor subtype-3\",\"id\":\"P32247\"},{\"label\":\"C3a anaphylatoxin chemotactic receptor\",\"id\":\"Q16581\"},{\"label\":\"C5a anaphylatoxin chemotactic receptor 1\",\"id\":\"P21730\"},{\"label\":\"C5a anaphylatoxin chemotactic receptor 2\",\"id\":\"Q9P296\"},{\"label\":\"Cholecystokinin receptor type A\",\"id\":\"P32238\"},{\"label\":\"Cholecystokinin\",\"id\":\"P06307\"},{\"label\":\"Complement C3\",\"id\":\"P01024\"},{\"label\":\"Complement C5\",\"id\":\"P01031\"},{\"label\":\"Cortistatin\",\"id\":\"O00230\"},{\"label\":\"Delta-type opioid receptor\",\"id\":\"P41143\"},{\"label\":\"Endoplasmic reticulum membrane adapter protein XK\",\"id\":\"P51811\"},{\"label\":\"Endothelin receptor type B\",\"id\":\"P24530\"},{\"label\":\"Endothelin-1 receptor\",\"id\":\"P25101\"},{\"label\":\"Endothelin-1\",\"id\":\"P05305\"},{\"label\":\"Endothelin-2\",\"id\":\"P20800\"},{\"label\":\"Endothelin-3\",\"id\":\"P14138\"},{\"label\":\"Endothelin-converting enzyme 1\",\"id\":\"P42892\"},{\"label\":\"Endothelin-converting enzyme 2\",\"id\":\"P0DPD6\"},{\"label\":\"G-protein coupled estrogen receptor 1\",\"id\":\"Q99527\"},{\"label\":\"G-protein coupled receptor 37-like 1\",\"id\":\"O60883\"},{\"label\":\"Galanin peptides\",\"id\":\"P22466\"},{\"label\":\"Galanin receptor type 1\",\"id\":\"P47211\"},{\"label\":\"Galanin receptor type 2\",\"id\":\"O43603\"},{\"label\":\"Galanin receptor type 3\",\"id\":\"O60755\"},{\"label\":\"Gastrin-releasing peptide receptor\",\"id\":\"P30550\"},{\"label\":\"Gastrin-releasing peptide\",\"id\":\"P07492\"},{\"label\":\"Gastrin/cholecystokinin type B 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4\",\"id\":\"Q99466\"},{\"label\":\"Protein sel-1 homolog 1\",\"id\":\"Q9UBV2\"},{\"label\":\"Ras-related protein Rab-6A\",\"id\":\"P20340\"},{\"label\":\"Sarcoplasmic/endoplasmic reticulum calcium ATPase 1\",\"id\":\"O14983\"},{\"label\":\"Sarcoplasmic/endoplasmic reticulum calcium ATPase 2\",\"id\":\"P16615\"},{\"label\":\"Sarcoplasmic/endoplasmic reticulum calcium ATPase 3\",\"id\":\"Q93084\"},{\"label\":\"Transmembrane emp24 domain-containing protein 2\",\"id\":\"Q15363\"},{\"label\":\"Type 2 lactosamine alpha-2,3-sialyltransferase\",\"id\":\"Q9Y274\"}]", "uniprot_id": "[\"O00587\",\"O14983\",\"P09958\",\"P15291\",\"P16615\",\"P20340\",\"P46531\",\"Q04721\",\"Q11203\",\"Q11206\",\"Q15363\",\"Q8NES3\",\"Q93084\",\"Q99466\",\"Q9UBV2\",\"Q9UM47\",\"Q9Y274\",\"Q9Y644\"]", "gene_symbol": 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substrate specificity ATP-binding cassette transporter ABCG2\",\"id\":\"Q9UNQ0\"},{\"label\":\"Ceruloplasmin\",\"id\":\"P00450\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"Cullin-associated NEDD8-dissociated protein 1\",\"id\":\"Q86VP6\"},{\"label\":\"Cytoplasmic aconitate hydratase\",\"id\":\"P21399\"},{\"label\":\"F-box/LRR-repeat protein 5\",\"id\":\"Q9UKA1\"},{\"label\":\"Ferritin heavy chain\",\"id\":\"P02794\"},{\"label\":\"Ferritin light chain\",\"id\":\"P02792\"},{\"label\":\"Ferritin, mitochondrial\",\"id\":\"Q8N4E7\"},{\"label\":\"Ferroportin\",\"id\":\"Q9NP59\"},{\"label\":\"Glutaredoxin-3\",\"id\":\"O76003\"},{\"label\":\"Heme oxygenase 1\",\"id\":\"P09601\"},{\"label\":\"Heme oxygenase 2\",\"id\":\"P30519\"},{\"label\":\"Hephaestin\",\"id\":\"Q9BQS7\"},{\"label\":\"Iron-responsive element-binding protein 2\",\"id\":\"P48200\"},{\"label\":\"NEDD8\",\"id\":\"Q15843\"},{\"label\":\"Natural resistance-associated macrophage protein 2\",\"id\":\"P49281\"},{\"label\":\"Neutrophil gelatinase-associated lipocalin\",\"id\":\"P80188\"},{\"label\":\"Plasma membrane ascorbate-dependent reductase CYBRD1\",\"id\":\"Q53TN4\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proton-coupled folate transporter\",\"id\":\"Q96NT5\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"Serotransferrin\",\"id\":\"P02787\"},{\"label\":\"Solute carrier family 22 member 17\",\"id\":\"Q8WUG5\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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"[\"\"]" }, { "pathway_label": "TICAM1 deficiency - HSE", "protein_name": "[{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"}]", "uniprot_id": "[\"O15455\",\"Q8IUC6\"]", "gene_symbol": "[\"PRVTIRB\",\"TICAM1\",\"TLR3\",\"TRIF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Pyrimidine catabolism", "protein_name": "[{\"label\":\"5'(3')-deoxyribonucleotidase, cytosolic type\",\"id\":\"Q8TCD5\"},{\"label\":\"5'(3')-deoxyribonucleotidase, mitochondrial\",\"id\":\"Q9NPB1\"},{\"label\":\"5'-nucleotidase\",\"id\":\"P21589\"},{\"label\":\"Alanine--glyoxylate aminotransferase 2, mitochondrial\",\"id\":\"Q9BYV1\"},{\"label\":\"Beta-ureidopropionase\",\"id\":\"Q9UBR1\"},{\"label\":\"Cytosolic 5'-nucleotidase 1A\",\"id\":\"Q9BXI3\"},{\"label\":\"Dihydropyrimidinase\",\"id\":\"Q14117\"},{\"label\":\"Dihydropyrimidine dehydrogenase [NADP(+)]\",\"id\":\"Q12882\"},{\"label\":\"Thymidine 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3-epimerase\",\"id\":\"Q96AT9\"},{\"label\":\"Sedoheptulokinase\",\"id\":\"Q9UHJ6\"},{\"label\":\"Transaldolase\",\"id\":\"P37837\"},{\"label\":\"Transketolase\",\"id\":\"P29401\"}]", "uniprot_id": "[\"O95336\",\"P11413\",\"P29401\",\"P37837\",\"P49247\",\"P52209\",\"Q2QD12\",\"Q96AT9\",\"Q96G03\",\"Q9H477\",\"Q9UHJ6\",\"Q9Y315\"]", "gene_symbol": "[\"CARKL\",\"DERA\",\"G6PD\",\"PGD\",\"PGDH\",\"PGLS\",\"PGM2\",\"RBKS\",\"RBSK\",\"RPE\",\"RPEL1\",\"RPI\",\"RPIA\",\"SHPK\",\"TAL\",\"TALDO\",\"TALDO1\",\"TALDOR\",\"TKT\"]", "gtc_id": "[\"G31080DL\"]" }, { "pathway_label": "Defective CHST14 causes EDS, musculocontractural type", "protein_name": "[{\"label\":\"Biglycan\",\"id\":\"P21810\"},{\"label\":\"Brevican core protein\",\"id\":\"Q96GW7\"},{\"label\":\"Carbohydrate sulfotransferase 14\",\"id\":\"Q8NCH0\"},{\"label\":\"Chondroitin sulfate proteoglycan 4\",\"id\":\"Q6UVK1\"},{\"label\":\"Chondroitin sulfate proteoglycan 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gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(q) subunit alpha\",\"id\":\"P50148\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-11\",\"id\":\"P29992\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-14\",\"id\":\"O95837\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-15\",\"id\":\"P30679\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Phosducin-like protein\",\"id\":\"Q13371\"},{\"label\":\"Regulator of G-protein signaling 11\",\"id\":\"O94810\"},{\"label\":\"Regulator of G-protein signaling 6\",\"id\":\"P49758\"},{\"label\":\"Regulator of G-protein signaling 7\",\"id\":\"P49802\"},{\"label\":\"Regulator of G-protein signaling 9\",\"id\":\"O75916\"},{\"label\":\"T-complex protein 1 subunit alpha\",\"id\":\"P17987\"},{\"label\":\"T-complex protein 1 subunit beta\",\"id\":\"P78371\"},{\"label\":\"T-complex protein 1 subunit delta\",\"id\":\"P50991\"},{\"label\":\"T-complex protein 1 subunit epsilon\",\"id\":\"P48643\"},{\"label\":\"T-complex protein 1 subunit eta\",\"id\":\"Q99832\"},{\"label\":\"T-complex protein 1 subunit gamma\",\"id\":\"P49368\"},{\"label\":\"T-complex protein 1 subunit theta\",\"id\":\"P50990\"},{\"label\":\"T-complex protein 1 subunit zeta-2\",\"id\":\"Q92526\"},{\"label\":\"T-complex protein 1 subunit zeta\",\"id\":\"P40227\"}]", "uniprot_id": 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alpha-1\",\"id\":\"P56199\"},{\"label\":\"Integrin alpha-2\",\"id\":\"P17301\"},{\"label\":\"Integrin alpha-3\",\"id\":\"P26006\"},{\"label\":\"Integrin alpha-6\",\"id\":\"P23229\"},{\"label\":\"Integrin alpha-7\",\"id\":\"Q13683\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin beta-4\",\"id\":\"P16144\"},{\"label\":\"Laminin subunit alpha-1\",\"id\":\"P25391\"},{\"label\":\"Laminin subunit alpha-2\",\"id\":\"P24043\"},{\"label\":\"Laminin subunit alpha-3\",\"id\":\"Q16787\"},{\"label\":\"Laminin subunit alpha-4\",\"id\":\"Q16363\"},{\"label\":\"Laminin subunit alpha-5\",\"id\":\"O15230\"},{\"label\":\"Laminin subunit beta-1\",\"id\":\"P07942\"},{\"label\":\"Laminin subunit beta-2\",\"id\":\"P55268\"},{\"label\":\"Laminin subunit beta-3\",\"id\":\"Q13751\"},{\"label\":\"Laminin subunit gamma-1\",\"id\":\"P11047\"},{\"label\":\"Laminin subunit gamma-2\",\"id\":\"Q13753\"},{\"label\":\"Laminin subunit gamma-3\",\"id\":\"Q9Y6N6\"},{\"label\":\"Nidogen-1\",\"id\":\"P14543\"},{\"label\":\"Nidogen-2\",\"id\":\"Q14112\"}]", "uniprot_id": "[\"O15230\",\"P05556\",\"P06756\",\"P07942\",\"P11047\",\"P14543\",\"P16144\",\"P17301\",\"P23229\",\"P24043\",\"P25391\",\"P26006\",\"P39060\",\"P55268\",\"P56199\",\"P98160\",\"Q13683\",\"Q13751\",\"Q13753\",\"Q14112\",\"Q16363\",\"Q16787\",\"Q9Y6N6\"]", "gene_symbol": "[\"CD49B\",\"COL18A1\",\"FNRB\",\"HSPG2\",\"ITGA1\",\"ITGA2\",\"ITGA3\",\"ITGA6\",\"ITGA7\",\"ITGAV\",\"ITGB1\",\"ITGB4\",\"KIAA0533\",\"KIAA1907\",\"LAMA\",\"LAMA1\",\"LAMA2\",\"LAMA3\",\"LAMA4\",\"LAMA5\",\"LAMB1\",\"LAMB2\",\"LAMB2T\",\"LAMB3\",\"LAMC1\",\"LAMC2\",\"LAMC3\",\"LAMM\",\"LAMNA\",\"LAMNB1\",\"LAMNB2\",\"LAMS\",\"MDF2\",\"MSK12\",\"MSK18\",\"MSK8\",\"NID\",\"NID1\",\"NID2\",\"VNRA\",\"VTNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "AKT-mediated inactivation of FOXO1A", "protein_name": "[{\"label\":\"Forkhead box protein O1\",\"id\":\"Q12778\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"}]", "uniprot_id": "[\"P31749\",\"P31751\",\"Q12778\",\"Q9Y243\"]", "gene_symbol": "[\"AKT1\",\"AKT2\",\"AKT3\",\"FKHR\",\"FOXO1\",\"FOXO1A\",\"PKB\",\"PKBG\",\"RAC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective MAN1B1 causes MRT15", "protein_name": "[{\"label\":\"Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase\",\"id\":\"Q9UKM7\"}]", "uniprot_id": "[\"Q9UKM7\"]", "gene_symbol": "[\"MAN1B1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of maresins", "protein_name": "[{\"label\":\"Bifunctional epoxide hydrolase 2\",\"id\":\"P34913\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"}]", "uniprot_id": "[\"P09917\",\"P34913\"]", "gene_symbol": "[\"ALOX5\",\"EPHX2\",\"LOG5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Histidine catabolism", "protein_name": "[{\"label\":\"Carnosine N-methyltransferase\",\"id\":\"Q8N4J0\"},{\"label\":\"Carnosine synthase 1\",\"id\":\"A5YM72\"},{\"label\":\"Formimidoyltransferase-cyclodeaminase\",\"id\":\"O95954\"},{\"label\":\"Histamine N-methyltransferase\",\"id\":\"P50135\"},{\"label\":\"Histidine ammonia-lyase\",\"id\":\"P42357\"},{\"label\":\"Histidine decarboxylase\",\"id\":\"P19113\"},{\"label\":\"Probable imidazolonepropionase\",\"id\":\"Q96NU7\"},{\"label\":\"Urocanate hydratase\",\"id\":\"Q96N76\"}]", "uniprot_id": "[\"A5YM72\",\"O95954\",\"P19113\",\"P42357\",\"P50135\",\"Q8N4J0\",\"Q96N76\",\"Q96NU7\"]", "gene_symbol": "[\"AMDHD1\",\"ATPGD1\",\"C9orf41\",\"CARNMT1\",\"CARNS1\",\"FTCD\",\"HAL\",\"HDC\",\"HIS\",\"HNMT\",\"KIAA1394\",\"UROC1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Glucocorticoid biosynthesis", "protein_name": "[{\"label\":\"11-beta-hydroxysteroid dehydrogenase 1\",\"id\":\"P28845\"},{\"label\":\"11-beta-hydroxysteroid dehydrogenase type 2\",\"id\":\"P80365\"},{\"label\":\"3 beta-hydroxysteroid dehydrogenase/Delta 5--\\u003e4-isomerase type 1\",\"id\":\"P14060\"},{\"label\":\"3 beta-hydroxysteroid dehydrogenase/Delta 5--\\u003e4-isomerase type 2\",\"id\":\"P26439\"},{\"label\":\"Corticosteroid-binding globulin\",\"id\":\"P08185\"},{\"label\":\"Cytochrome P450 11B1, mitochondrial\",\"id\":\"P15538\"},{\"label\":\"Cytochrome P450 11B2, mitochondrial\",\"id\":\"P19099\"},{\"label\":\"Pro-opiomelanocortin\",\"id\":\"P01189\"},{\"label\":\"Steroid 17-alpha-hydroxylase/17,20 lyase\",\"id\":\"P05093\"},{\"label\":\"Steroid 21-hydroxylase\",\"id\":\"P08686\"}]", "uniprot_id": "[\"P01189\",\"P05093\",\"P08185\",\"P08686\",\"P14060\",\"P15538\",\"P19099\",\"P26439\",\"P28845\",\"P80365\"]", "gene_symbol": 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5\",\"id\":\"Q71RS6\"},{\"label\":\"Sorcin\",\"id\":\"P30626\"}]", "uniprot_id": "[\"O60721\",\"P0DP23\",\"P30626\",\"P32418\",\"P57103\",\"Q6J4K2\",\"Q71RS6\",\"Q8NFF2\",\"Q9HC58\",\"Q9UI40\",\"Q9UPR5\"]", "gene_symbol": "[\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CNC\",\"JSX\",\"KIAA0702\",\"KIAA1087\",\"NCKX1\",\"NCKX2\",\"NCKX3\",\"NCKX4\",\"NCKX5\",\"NCKX6\",\"NCLX\",\"NCX1\",\"NCX2\",\"NCX3\",\"SLC24A1\",\"SLC24A2\",\"SLC24A3\",\"SLC24A4\",\"SLC24A5\",\"SLC24A6\",\"SLC8A1\",\"SLC8A2\",\"SLC8A3\",\"SLC8B1\",\"SRI\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NGF-stimulated transcription", "protein_name": "[{\"label\":\"Achaete-scute homolog 1\",\"id\":\"P50553\"},{\"label\":\"Activity-regulated cytoskeleton-associated protein\",\"id\":\"Q7LC44\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 4\",\"id\":\"Q14839\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-1\",\"id\":\"P18846\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-2\",\"id\":\"P15336\"},{\"label\":\"Cyclin-dependent kinase 5 activator 1\",\"id\":\"Q15078\"},{\"label\":\"Cyclin-dependent kinase 5 activator 2\",\"id\":\"Q13319\"},{\"label\":\"Cyclin-dependent kinase 5\",\"id\":\"Q00535\"},{\"label\":\"DNA-binding protein inhibitor ID-1\",\"id\":\"P41134\"},{\"label\":\"DNA-binding protein inhibitor ID-2\",\"id\":\"Q02363\"},{\"label\":\"DNA-binding protein inhibitor ID-3\",\"id\":\"Q02535\"},{\"label\":\"DNA-binding protein inhibitor ID-4\",\"id\":\"P47928\"},{\"label\":\"Dynamin-2\",\"id\":\"P50570\"},{\"label\":\"E3 SUMO-protein ligase EGR2\",\"id\":\"P11161\"},{\"label\":\"ETS domain-containing protein Elk-1\",\"id\":\"P19419\"},{\"label\":\"Early growth response protein 1\",\"id\":\"P18146\"},{\"label\":\"Early growth response protein 3\",\"id\":\"Q06889\"},{\"label\":\"Early growth response protein 4\",\"id\":\"Q05215\"},{\"label\":\"Endophilin-A3\",\"id\":\"Q99963\"},{\"label\":\"Fos-related antigen 1\",\"id\":\"P15407\"},{\"label\":\"GTP-binding protein RAD\",\"id\":\"P55042\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Myocyte-specific enhancer factor 2D\",\"id\":\"Q14814\"},{\"label\":\"NGFI-A-binding protein 1\",\"id\":\"Q13506\"},{\"label\":\"NGFI-A-binding protein 2\",\"id\":\"Q15742\"},{\"label\":\"Neurosecretory protein VGF\",\"id\":\"O15240\"},{\"label\":\"Protein FosB\",\"id\":\"P53539\"},{\"label\":\"Protein c-Fos\",\"id\":\"P01100\"},{\"label\":\"Protein lyl-1\",\"id\":\"P12980\"},{\"label\":\"RE1-silencing transcription factor\",\"id\":\"Q13127\"},{\"label\":\"Serine/threonine-protein kinase Sgk1\",\"id\":\"O00141\"},{\"label\":\"Serum response factor\",\"id\":\"P11831\"},{\"label\":\"Tissue factor\",\"id\":\"P13726\"},{\"label\":\"Transcription factor 12\",\"id\":\"Q99081\"},{\"label\":\"Transcription factor JunB\",\"id\":\"P17275\"},{\"label\":\"Transcription factor JunD\",\"id\":\"P17535\"},{\"label\":\"Tribbles homolog 1\",\"id\":\"Q96RU8\"},{\"label\":\"Tryptophan 5-hydroxylase 1\",\"id\":\"P17752\"}]", "uniprot_id": "[\"O00141\",\"O15240\",\"P01100\",\"P11161\",\"P11831\",\"P12980\",\"P13726\",\"P15336\",\"P15407\",\"P17275\",\"P17535\",\"P17752\",\"P18146\",\"P18846\",\"P19419\",\"P41134\",\"P47928\",\"P50553\",\"P50570\",\"P53539\",\"P55042\",\"Q00535\",\"Q02363\",\"Q02535\",\"Q05215\",\"Q06889\",\"Q09472\",\"Q13127\",\"Q13319\",\"Q13506\",\"Q14814\",\"Q14839\",\"Q15078\",\"Q15742\",\"Q7LC44\",\"Q96RU8\",\"Q99081\",\"Q99963\"]", "gene_symbol": 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"gene_symbol": "[\"KIT\",\"SCFR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "DAG and IP3 signaling", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1\",\"id\":\"Q14643\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2\",\"id\":\"Q14571\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3\",\"id\":\"Q14573\"},{\"label\":\"Protein kinase C delta type\",\"id\":\"Q05655\"},{\"label\":\"Protein kinase C epsilon type\",\"id\":\"Q02156\"},{\"label\":\"S-adenosylhomocysteine hydrolase-like protein 1\",\"id\":\"O43865\"}]", "uniprot_id": "[\"O43865\",\"P19174\",\"Q02156\",\"Q05655\",\"Q14571\",\"Q14573\",\"Q14643\"]", "gene_symbol": "[\"AHCYL1\",\"DCAL\",\"INSP3R1\",\"IRBIT\",\"ITPR1\",\"ITPR2\",\"ITPR3\",\"PKCD\",\"PKCE\",\"PLC1\",\"PLCG1\",\"PRKCD\",\"PRKCE\",\"XPVKONA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcriptional activation of cell cycle inhibitor p21", "protein_name": "[{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Poly(rC)-binding protein 4\",\"id\":\"P57723\"},{\"label\":\"Zinc finger protein 385A\",\"id\":\"Q96PM9\"}]", "uniprot_id": "[\"P04637\",\"P38936\",\"P57723\",\"Q96PM9\"]", "gene_symbol": "[\"CAP20\",\"CDKN1\",\"CDKN1A\",\"CIP1\",\"HZF\",\"MDA6\",\"P53\",\"PCBP4\",\"PIC1\",\"RZF\",\"SDI1\",\"TP53\",\"WAF1\",\"ZNF385\",\"ZNF385A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CREB1 phosphorylation through the activation of Adenylate Cyclase", "protein_name": "[{\"label\":\"Adenylate cyclase type 1\",\"id\":\"Q08828\"},{\"label\":\"Adenylate cyclase type 8\",\"id\":\"P40145\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit PRKX\",\"id\":\"P51817\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"},{\"label\":\"cAMP-dependent protein kinase type I-alpha regulatory subunit\",\"id\":\"P10644\"},{\"label\":\"cAMP-dependent protein kinase type I-beta regulatory subunit\",\"id\":\"P31321\"},{\"label\":\"cAMP-dependent protein kinase type II-alpha regulatory subunit\",\"id\":\"P13861\"},{\"label\":\"cAMP-dependent protein kinase type II-beta regulatory subunit\",\"id\":\"P31323\"}]", "uniprot_id": "[\"P0DP23\",\"P10644\",\"P13861\",\"P17612\",\"P22612\",\"P22694\",\"P31321\",\"P31323\",\"P40145\",\"P51817\",\"Q08828\"]", "gene_symbol": "[\"ADCY1\",\"ADCY8\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"PKACA\",\"PKR1\",\"PKR2\",\"PKX1\",\"PRKACA\",\"PRKACB\",\"PRKACG\",\"PRKAR1\",\"PRKAR1A\",\"PRKAR1B\",\"PRKAR2\",\"PRKAR2A\",\"PRKAR2B\",\"PRKX\",\"TSE1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "crenolanib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of HMOX1 expression and activity", "protein_name": "[{\"label\":\"Heme oxygenase 1\",\"id\":\"P09601\"},{\"label\":\"Minor histocompatibility antigen H13\",\"id\":\"Q8TCT9\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"},{\"label\":\"Transcription factor MafK\",\"id\":\"O60675\"},{\"label\":\"Transcription regulator protein BACH1\",\"id\":\"O14867\"}]", "uniprot_id": "[\"O14867\",\"O60675\",\"P09601\",\"Q16236\",\"Q8TCT9\"]", "gene_symbol": "[\"BACH1\",\"H13\",\"HM13\",\"HMOX1\",\"HO\",\"HO1\",\"IMP1\",\"MAFK\",\"NFE2L2\",\"NRF2\",\"PSL3\",\"SPP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)", "protein_name": "[{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"Q9Y6K9\"]", "gene_symbol": "[\"CHUK\",\"FIP3\",\"IKBKB\",\"IKBKG\",\"IKKA\",\"IKKB\",\"NEMO\",\"TCF16\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Purinergic signaling in leishmaniasis infection", "protein_name": "[{\"label\":\"5'-nucleotidase\",\"id\":\"P21589\"},{\"label\":\"Apoptosis-associated speck-like protein containing a CARD\",\"id\":\"Q9ULZ3\"},{\"label\":\"C3a anaphylatoxin chemotactic receptor\",\"id\":\"Q16581\"},{\"label\":\"Caspase-1\",\"id\":\"P29466\"},{\"label\":\"Cathepsin G\",\"id\":\"P08311\"},{\"label\":\"Complement C3\",\"id\":\"P01024\"},{\"label\":\"Ectonucleoside triphosphate diphosphohydrolase 1\",\"id\":\"P49961\"},{\"label\":\"Gasdermin-D\",\"id\":\"P57764\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Heme oxygenase 1\",\"id\":\"P09601\"},{\"label\":\"Interleukin-1 alpha\",\"id\":\"P01583\"},{\"label\":\"Interleukin-1 beta\",\"id\":\"P01584\"},{\"label\":\"Interleukin-18\",\"id\":\"Q14116\"},{\"label\":\"NACHT, LRR and PYD domains-containing protein 3\",\"id\":\"Q96P20\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Nucleoside diphosphate phosphatase ENTPD5\",\"id\":\"O75356\"},{\"label\":\"P2X purinoceptor 4\",\"id\":\"Q99571\"},{\"label\":\"P2X purinoceptor 7\",\"id\":\"Q99572\"},{\"label\":\"Proline-serine-threonine phosphatase-interacting protein 1\",\"id\":\"O43586\"},{\"label\":\"Protein SGT1 homolog\",\"id\":\"Q9Y2Z0\"},{\"label\":\"Pyrin\",\"id\":\"O15553\"},{\"label\":\"Thioredoxin-interacting protein\",\"id\":\"Q9H3M7\"},{\"label\":\"Thioredoxin\",\"id\":\"P10599\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": "[\"O15553\",\"O43586\",\"O75356\",\"P01024\",\"P01583\",\"P01584\",\"P08238\",\"P08311\",\"P09601\",\"P10599\",\"P19838\",\"P21589\",\"P29466\",\"P49961\",\"P57764\",\"Q00653\",\"Q04206\",\"Q14116\",\"Q16581\",\"Q96P20\",\"Q99571\",\"Q99572\",\"Q9H3M7\",\"Q9ULZ3\",\"Q9Y2Z0\"]", "gene_symbol": "[\"ASC\",\"AZ3B\",\"C1orf7\",\"C3\",\"C3AR1\",\"C3R1\",\"CARD5\",\"CASP1\",\"CD2BP1\",\"CD39\",\"CD39L4\",\"CIAS1\",\"CPAMD1\",\"CTSG\",\"DFNA5L\",\"ENTPD1\",\"ENTPD5\",\"GSDMD\",\"GSDMDC1\",\"HMOX1\",\"HNFAG09\",\"HO\",\"HO1\",\"HSP90AB1\",\"HSP90B\",\"HSPC2\",\"HSPC3\",\"HSPCB\",\"IGIF\",\"IL18\",\"IL1A\",\"IL1B\",\"IL1BC\",\"IL1BCE\",\"IL1F1\",\"IL1F2\",\"IL1F4\",\"LYT10\",\"MEF\",\"MEFV\",\"NALP3\",\"NFKB1\",\"NFKB2\",\"NFKB3\",\"NLRP3\",\"NT5\",\"NT5E\",\"NTE\",\"P2RX4\",\"P2RX7\",\"PCPH\",\"PSTPIP1\",\"PYCARD\",\"PYPAF1\",\"RELA\",\"SUGT1\",\"TMS1\",\"TRDX\",\"TRIM20\",\"TRX\",\"TRX1\",\"TXN\",\"TXNIP\",\"VDUP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RHOT2 GTPase cycle", "protein_name": "[{\"label\":\"Mitochondrial Rho GTPase 2\",\"id\":\"Q8IXI1\"},{\"label\":\"Mitofusin-1\",\"id\":\"Q8IWA4\"},{\"label\":\"Mitofusin-2\",\"id\":\"O95140\"},{\"label\":\"Rap1 GTPase-GDP dissociation stimulator 1\",\"id\":\"P52306\"},{\"label\":\"Trafficking kinesin-binding protein 1\",\"id\":\"Q9UPV9\"},{\"label\":\"Trafficking kinesin-binding protein 2\",\"id\":\"O60296\"},{\"label\":\"Unconventional myosin-XIX\",\"id\":\"Q96H55\"}]", "uniprot_id": "[\"O60296\",\"O95140\",\"P52306\",\"Q8IWA4\",\"Q8IXI1\",\"Q96H55\",\"Q9UPV9\"]", "gene_symbol": "[\"ALS2CR3\",\"ARHT2\",\"C16orf39\",\"CPRP1\",\"KIAA0214\",\"KIAA0549\",\"KIAA1042\",\"MFN1\",\"MFN2\",\"MYO19\",\"MYOHD1\",\"OIP106\",\"RAP1GDS1\",\"RHOT2\",\"SMGGDS\",\"TRAK1\",\"TRAK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Plus-strand DNA synthesis", "protein_name": "[{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Protein Rev\",\"id\":\"P04618\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"P04585\",\"P04591\",\"P04618\",\"P05919\",\"P62937\",\"P69723\",\"P69726\"]", "gene_symbol": "[\"CYPA\",\"PPIA\",\"gag\",\"gag-pol\",\"rev\",\"vif\",\"vpr\",\"vpu\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Orexin and neuropeptides FF and QRFP bind to their respective receptors", "protein_name": "[{\"label\":\"Hypocretin neuropeptide precursor\",\"id\":\"O43612\"},{\"label\":\"Neuropeptide FF receptor 1\",\"id\":\"Q9GZQ6\"},{\"label\":\"Neuropeptide FF receptor 2\",\"id\":\"Q9Y5X5\"},{\"label\":\"Orexigenic neuropeptide QRFP\",\"id\":\"P83859\"},{\"label\":\"Orexin receptor type 2\",\"id\":\"O43614\"},{\"label\":\"Orexin/Hypocretin receptor type 1\",\"id\":\"O43613\"},{\"label\":\"Pro-FMRFamide-related neuropeptide FF\",\"id\":\"O15130\"},{\"label\":\"Pyroglutamylated RF-amide peptide receptor\",\"id\":\"Q96P65\"}]", "uniprot_id": "[\"O15130\",\"O43612\",\"O43613\",\"O43614\",\"P83859\",\"Q96P65\",\"Q9GZQ6\",\"Q9Y5X5\"]", "gene_symbol": "[\"GPR103\",\"GPR147\",\"GPR74\",\"HCRT\",\"HCRTR1\",\"HCRTR2\",\"NPFF\",\"NPFF1\",\"NPFF2\",\"NPFFR1\",\"NPFFR2\",\"NPGPR\",\"OX\",\"PPORX\",\"PPOX\",\"QRFP\",\"QRFPR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signal regulatory protein family interactions", "protein_name": "[{\"label\":\"FYN-binding protein 1\",\"id\":\"O15117\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Leukocyte surface antigen CD47\",\"id\":\"Q08722\"},{\"label\":\"Protein-tyrosine kinase 2-beta\",\"id\":\"Q14289\"},{\"label\":\"Signal-regulatory protein beta-1\",\"id\":\"O00241\"},{\"label\":\"Signal-regulatory protein gamma\",\"id\":\"Q9P1W8\"},{\"label\":\"Src kinase-associated phosphoprotein 2\",\"id\":\"O75563\"},{\"label\":\"TYRO protein tyrosine kinase-binding protein\",\"id\":\"O43914\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type substrate 1\",\"id\":\"P78324\"}]", "uniprot_id": "[\"O00241\",\"O15117\",\"O43914\",\"O75563\",\"P29350\",\"P78324\",\"Q05397\",\"Q06124\",\"Q08722\",\"Q14289\",\"Q9P1W8\"]", "gene_symbol": "[\"BIT\",\"CD47\",\"DAP12\",\"FAK\",\"FAK1\",\"FAK2\",\"FYB\",\"FYB1\",\"HCP\",\"KARAP\",\"MER6\",\"MFR\",\"MYD1\",\"PRAP\",\"PTK2\",\"PTK2B\",\"PTP1C\",\"PTP2C\",\"PTPN11\",\"PTPN6\",\"PTPNS1\",\"PYK2\",\"RA70\",\"RAFTK\",\"SAPS\",\"SCAP2\",\"SHPS1\",\"SHPTP2\",\"SIRP\",\"SIRPA\",\"SIRPB1\",\"SIRPB2\",\"SIRPG\",\"SKAP2\",\"SKAP55R\",\"SLAP130\",\"TYROBP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Lysosome Vesicle Biogenesis", "protein_name": "[{\"label\":\"ADP-ribosylation factor 1\",\"id\":\"P84077\"},{\"label\":\"AP-1 complex subunit beta-1\",\"id\":\"Q10567\"},{\"label\":\"AP-1 complex subunit gamma-1\",\"id\":\"O43747\"},{\"label\":\"AP-1 complex subunit gamma-like 2\",\"id\":\"O75843\"},{\"label\":\"AP-1 complex subunit mu-1\",\"id\":\"Q9BXS5\"},{\"label\":\"AP-1 complex subunit mu-2\",\"id\":\"Q9Y6Q5\"},{\"label\":\"AP-1 complex subunit sigma-1A\",\"id\":\"P61966\"},{\"label\":\"AP-1 complex subunit sigma-2\",\"id\":\"P56377\"},{\"label\":\"AP-1 complex subunit sigma-3\",\"id\":\"Q96PC3\"},{\"label\":\"AP-4 complex subunit beta-1\",\"id\":\"Q9Y6B7\"},{\"label\":\"AP-4 complex subunit epsilon-1\",\"id\":\"Q9UPM8\"},{\"label\":\"AP-4 complex subunit mu-1\",\"id\":\"O00189\"},{\"label\":\"AP-4 complex subunit sigma-1\",\"id\":\"Q9Y587\"},{\"label\":\"Amyloid-beta precursor protein\",\"id\":\"P05067\"},{\"label\":\"Auxilin\",\"id\":\"O75061\"},{\"label\":\"Beta-arrestin-1\",\"id\":\"P49407\"},{\"label\":\"Biogenesis of lysosome-related organelles complex 1 subunit 1\",\"id\":\"P78537\"},{\"label\":\"Cathepsin Z\",\"id\":\"Q9UBR2\"},{\"label\":\"Cation-dependent mannose-6-phosphate receptor\",\"id\":\"P20645\"},{\"label\":\"Charged multivesicular body protein 2a\",\"id\":\"O43633\"},{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Clathrin light chain A\",\"id\":\"P09496\"},{\"label\":\"Clathrin light chain B\",\"id\":\"P09497\"},{\"label\":\"Clavesin-1\",\"id\":\"Q8IUQ0\"},{\"label\":\"Clavesin-2\",\"id\":\"Q5SYC1\"},{\"label\":\"Deoxyribonuclease-2-alpha\",\"id\":\"O00115\"},{\"label\":\"Dynamin-2\",\"id\":\"P50570\"},{\"label\":\"Endophilin-A1\",\"id\":\"Q99962\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Hepatocyte growth factor-regulated tyrosine kinase substrate\",\"id\":\"O14964\"},{\"label\":\"N-acetylglucosamine-6-sulfatase\",\"id\":\"P15586\"},{\"label\":\"Thioredoxin domain-containing protein 5\",\"id\":\"Q8NBS9\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"},{\"label\":\"Vesicle-associated membrane protein 7\",\"id\":\"P51809\"},{\"label\":\"Vesicle-associated membrane protein 8\",\"id\":\"Q9BV40\"}]", "uniprot_id": "[\"O00115\",\"O00189\",\"O14964\",\"O43633\",\"O43747\",\"O75061\",\"O75843\",\"P05067\",\"P09496\",\"P09497\",\"P11142\",\"P15586\",\"P20645\",\"P49407\",\"P50570\",\"P51809\",\"P56377\",\"P61966\",\"P63027\",\"P78537\",\"P84077\",\"Q00610\",\"Q10567\",\"Q5SYC1\",\"Q8IUQ0\",\"Q8NBS9\",\"Q96PC3\",\"Q99962\",\"Q9BV40\",\"Q9BXS5\",\"Q9UBR2\",\"Q9UPM8\",\"Q9Y587\",\"Q9Y6B7\",\"Q9Y6Q5\"]", "gene_symbol": 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beta-2\",\"id\":\"O43741\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-2\",\"id\":\"Q9UGJ0\"},{\"label\":\"Carnitine O-palmitoyltransferase 1, liver isoform\",\"id\":\"P50416\"},{\"label\":\"Carnitine O-palmitoyltransferase 1, muscle isoform\",\"id\":\"Q92523\"},{\"label\":\"Carnitine O-palmitoyltransferase 2, mitochondrial\",\"id\":\"P23786\"},{\"label\":\"Mid1-interacting protein 1\",\"id\":\"Q9NPA3\"},{\"label\":\"Mitochondrial carnitine/acylcarnitine carrier protein\",\"id\":\"O43772\"},{\"label\":\"Organic cation/carnitine transporter 2\",\"id\":\"O76082\"},{\"label\":\"Peroxisome proliferator-activated receptor delta\",\"id\":\"Q03181\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Thyroid hormone-inducible hepatic protein\",\"id\":\"Q92748\"}]", "uniprot_id": "[\"O43741\",\"O43772\",\"O76082\",\"P19793\",\"P23786\",\"P50416\",\"P54646\",\"Q03181\",\"Q92523\",\"Q92748\",\"Q9NPA3\",\"Q9UGJ0\"]", "gene_symbol": 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3\",\"id\":\"Q15185\"},{\"label\":\"Serine/threonine-protein phosphatase 5\",\"id\":\"P53041\"}]", "uniprot_id": "[\"P03372\",\"P07900\",\"P08238\",\"P27361\",\"P28482\",\"P53041\",\"Q02790\",\"Q08752\",\"Q13451\",\"Q15185\",\"Q92731\"]", "gene_symbol": "[\"AIG6\",\"CYP40\",\"CYPD\",\"ERK1\",\"ERK2\",\"ESR\",\"ESR1\",\"ESR2\",\"ESTRB\",\"FKBP4\",\"FKBP5\",\"FKBP51\",\"FKBP52\",\"HSP90A\",\"HSP90AA1\",\"HSP90AB1\",\"HSP90B\",\"HSPC1\",\"HSPC2\",\"HSPC3\",\"HSPCA\",\"HSPCB\",\"MAPK1\",\"MAPK3\",\"NR3A1\",\"NR3A2\",\"P23\",\"PPID\",\"PPP5\",\"PPP5C\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"PTGES3\",\"TEBP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by LTK", "protein_name": "[{\"label\":\"ALK and LTK ligand 1\",\"id\":\"Q6UXT8\"},{\"label\":\"ALK and LTK ligand 2\",\"id\":\"Q6UX46\"},{\"label\":\"Activated CDC42 kinase 1\",\"id\":\"Q07912\"},{\"label\":\"Growth factor receptor-bound protein 2\",\"id\":\"P62993\"},{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Leukocyte tyrosine kinase receptor\",\"id\":\"P29376\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O00459\",\"P27986\",\"P29376\",\"P35568\",\"P42336\",\"P42338\",\"P62993\",\"Q07889\",\"Q07912\",\"Q6UX46\",\"Q6UXT8\"]", "gene_symbol": "[\"ACK1\",\"ALKAL1\",\"ALKAL2\",\"ASH\",\"FAM150A\",\"FAM150B\",\"GRB1\",\"GRB2\",\"IRS1\",\"LTK\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3R1\",\"PIK3R2\",\"SOS1\",\"TNK2\",\"TYK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NEP/NS2 Interacts with the Cellular Export Machinery", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"GTP-binding nuclear protein Ran\",\"id\":\"P62826\"},{\"label\":\"Matrix protein 1\",\"id\":\"P03485\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear export protein\",\"id\":\"P03508\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": "[\"A8CG34\",\"O14980\",\"O15504\",\"O75694\",\"P03428\",\"P03431\",\"P03433\",\"P03466\",\"P03485\",\"P03508\",\"P12270\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P55735\",\"P57740\",\"P62826\",\"P78406\",\"Q12769\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8N1F7\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q96HA1\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9NRG9\",\"Q9UKX7\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of insulin secretion", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 8\",\"id\":\"Q09428\"},{\"label\":\"ATP-sensitive inward rectifier potassium channel 11\",\"id\":\"Q14654\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-1\",\"id\":\"P63096\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-2\",\"id\":\"P04899\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1\",\"id\":\"Q14643\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2\",\"id\":\"Q14571\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3\",\"id\":\"Q14573\"},{\"label\":\"Insulin\",\"id\":\"P01308\"},{\"label\":\"Rap guanine nucleotide exchange factor 3\",\"id\":\"O95398\"},{\"label\":\"Rap guanine nucleotide exchange factor 4\",\"id\":\"Q8WZA2\"},{\"label\":\"S-adenosylhomocysteine hydrolase-like protein 1\",\"id\":\"O43865\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 1\",\"id\":\"P11166\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 2\",\"id\":\"P11168\"},{\"label\":\"Synaptosomal-associated protein 25\",\"id\":\"P60880\"},{\"label\":\"Synaptotagmin-5\",\"id\":\"O00445\"},{\"label\":\"Syntaxin-1A\",\"id\":\"Q16623\"},{\"label\":\"Syntaxin-binding protein 1\",\"id\":\"P61764\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit alpha-1C\",\"id\":\"Q13936\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit alpha-1D\",\"id\":\"Q01668\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-2\",\"id\":\"Q08289\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-3\",\"id\":\"P54284\"},{\"label\":\"Voltage-dependent P/Q-type calcium channel subunit alpha-1A\",\"id\":\"O00555\"},{\"label\":\"Voltage-dependent R-type calcium channel subunit alpha-1E\",\"id\":\"Q15878\"},{\"label\":\"Voltage-dependent calcium channel subunit alpha-2/delta-2\",\"id\":\"Q9NY47\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": "[\"O00445\",\"O00555\",\"O43865\",\"O95398\",\"P01308\",\"P04899\",\"P11166\",\"P11168\",\"P17612\",\"P22612\",\"P22694\",\"P54284\",\"P60880\",\"P61764\",\"P63027\",\"P63096\",\"Q01668\",\"Q08289\",\"Q09428\",\"Q13936\",\"Q14571\",\"Q14573\",\"Q14643\",\"Q14654\",\"Q15878\",\"Q16623\",\"Q8WZA2\",\"Q9NY47\"]", "gene_symbol": 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NUBP2\",\"id\":\"Q9Y5Y2\"},{\"label\":\"Cytosolic iron-sulfur assembly component 2B\",\"id\":\"Q9Y3D0\"},{\"label\":\"Cytosolic iron-sulfur assembly component 3\",\"id\":\"Q9H6Q4\"},{\"label\":\"DNA polymerase delta catalytic subunit\",\"id\":\"P28340\"},{\"label\":\"Fanconi anemia group J protein\",\"id\":\"Q9BX63\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"Iron-sulfur clusters transporter ABCB7, mitochondrial\",\"id\":\"O75027\"},{\"label\":\"MMS19 nucleotide excision repair protein homolog\",\"id\":\"Q96T76\"},{\"label\":\"NADPH-dependent diflavin oxidoreductase 1\",\"id\":\"Q9UHB4\"},{\"label\":\"Probable cytosolic iron-sulfur protein assembly protein CIAO1\",\"id\":\"O76071\"},{\"label\":\"Regulator of telomere elongation helicase 1\",\"id\":\"Q9NZ71\"}]", "uniprot_id": 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1\",\"id\":\"Q14914\"}]", "uniprot_id": "[\"P09917\",\"P15428\",\"P18054\",\"P20292\",\"Q14914\",\"Q16873\"]", "gene_symbol": "[\"12LO\",\"ALOX12\",\"ALOX5\",\"ALOX5AP\",\"FLAP\",\"HPGD\",\"LOG12\",\"LOG5\",\"LTB4DH\",\"LTC4S\",\"PGDH1\",\"PTGR1\",\"SDR36C1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Scavenging by Class F Receptors", "protein_name": "[{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Calreticulin\",\"id\":\"P27797\"},{\"label\":\"Heat shock protein 105 kDa\",\"id\":\"Q92598\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hypoxia up-regulated protein 1\",\"id\":\"Q9Y4L1\"},{\"label\":\"Major outer membrane protein P.IB\",\"id\":\"P18195\"},{\"label\":\"Scavenger receptor class F member 1\",\"id\":\"Q14162\"}]", "uniprot_id": "[\"P04114\",\"P07900\",\"P18195\",\"P27797\",\"Q14162\",\"Q92598\",\"Q9Y4L1\"]", "gene_symbol": "[\"APOB\",\"CALR\",\"CRTC\",\"GRP170\",\"HSP105\",\"HSP110\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"HSPH1\",\"HSPH4\",\"HYOU1\",\"KIAA0149\",\"KIAA0201\",\"ORP150\",\"SCARF1\",\"SREC\",\"porB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RHO GTPases activate IQGAPs", "protein_name": "[{\"label\":\"CAP-Gly domain-containing linker protein 1\",\"id\":\"P30622\"},{\"label\":\"Cadherin-1\",\"id\":\"P12830\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Catenin alpha-1\",\"id\":\"P35221\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Menin\",\"id\":\"O00255\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP1\",\"id\":\"P46940\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP2\",\"id\":\"Q13576\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP3\",\"id\":\"Q86VI3\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"}]", "uniprot_id": "[\"O00255\",\"P0DP23\",\"P12830\",\"P30622\",\"P35221\",\"P35222\",\"P46940\",\"P60953\",\"P63000\",\"Q13576\",\"Q86VI3\"]", "gene_symbol": "[\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CDC42\",\"CDH1\",\"CDHE\",\"CLIP1\",\"CTNNA1\",\"CTNNB\",\"CTNNB1\",\"CYLN1\",\"IQGAP1\",\"IQGAP2\",\"IQGAP3\",\"KIAA0051\",\"MEN1\",\"RAC1\",\"RSN\",\"SCG2\",\"TC25\",\"UVO\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of dolichyl-phosphate mannose", "protein_name": "[{\"label\":\"Dolichol phosphate-mannose biosynthesis regulatory protein\",\"id\":\"O94777\"},{\"label\":\"Dolichol-phosphate mannosyltransferase subunit 1\",\"id\":\"O60762\"},{\"label\":\"Dolichol-phosphate mannosyltransferase subunit 3\",\"id\":\"Q9P2X0\"}]", "uniprot_id": "[\"O60762\",\"O94777\",\"Q9P2X0\"]", "gene_symbol": "[\"DPM1\",\"DPM2\",\"DPM3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Translesion synthesis by REV1", "protein_name": "[{\"label\":\"DNA polymerase zeta catalytic subunit\",\"id\":\"O60673\"},{\"label\":\"DNA repair protein REV1\",\"id\":\"Q9UBZ9\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2B\",\"id\":\"Q9UI95\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Replication factor C subunit 1\",\"id\":\"P35251\"},{\"label\":\"Replication factor C subunit 2\",\"id\":\"P35250\"},{\"label\":\"Replication factor C subunit 3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O60673\",\"P0CG47\",\"P0CG48\",\"P12004\",\"P15927\",\"P27694\",\"P35244\",\"P35249\",\"P35250\",\"P35251\",\"P40937\",\"P40938\",\"P62979\",\"P62987\",\"Q9UBZ9\",\"Q9UI95\"]", "gene_symbol": "[\"MAD2B\",\"MAD2L2\",\"PCNA\",\"POLZ\",\"REPA1\",\"REPA2\",\"REPA3\",\"REV1\",\"REV1L\",\"REV3\",\"REV3L\",\"REV7\",\"RFC1\",\"RFC140\",\"RFC2\",\"RFC3\",\"RFC4\",\"RFC5\",\"RPA1\",\"RPA14\",\"RPA2\",\"RPA3\",\"RPA32\",\"RPA34\",\"RPA70\",\"RPS27A\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CD28 dependent PI3K/Akt signaling", "protein_name": "[{\"label\":\"3-phosphoinositide-dependent protein kinase 1\",\"id\":\"O15530\"},{\"label\":\"Acyl-coenzyme A thioesterase THEM4\",\"id\":\"Q5T1C6\"},{\"label\":\"Membrane protein\",\"id\":\"P0DTC5\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 14\",\"id\":\"Q99558\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 8\",\"id\":\"P41279\"},{\"label\":\"Nucleoprotein\",\"id\":\"P0DTC9\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Proline-rich protein 5\",\"id\":\"P85299\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Rapamycin-insensitive companion of mTOR\",\"id\":\"Q6R327\"},{\"label\":\"Serine/threonine-protein kinase mTOR\",\"id\":\"P42345\"},{\"label\":\"T-cell-specific surface glycoprotein CD28\",\"id\":\"P10747\"},{\"label\":\"T-lymphocyte activation antigen CD80\",\"id\":\"P33681\"},{\"label\":\"T-lymphocyte activation antigen CD86\",\"id\":\"P42081\"},{\"label\":\"Target of rapamycin complex 2 subunit MAPKAP1\",\"id\":\"Q9BPZ7\"},{\"label\":\"Target of rapamycin complex subunit LST8\",\"id\":\"Q9BVC4\"},{\"label\":\"Tribbles homolog 3\",\"id\":\"Q96RU7\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"}]", "uniprot_id": "[\"O00459\",\"O15530\",\"P06239\",\"P06241\",\"P0DTC5\",\"P0DTC9\",\"P10747\",\"P27986\",\"P31749\",\"P31751\",\"P33681\",\"P41279\",\"P42081\",\"P42336\",\"P42345\",\"P85299\",\"Q5T1C6\",\"Q6R327\",\"Q92569\",\"Q96RU7\",\"Q99558\",\"Q9BPZ7\",\"Q9BVC4\",\"Q9Y243\"]", "gene_symbol": 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"[\"P19793\",\"P28702\",\"P35558\",\"P48552\",\"Q13133\"]", "gene_symbol": "[\"LXRA\",\"NR1H3\",\"NR2B1\",\"NR2B2\",\"NRIP1\",\"PCK1\",\"PEPCK1\",\"RXRA\",\"RXRB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "p75NTR negatively regulates cell cycle via SC1", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone deacetylase 2\",\"id\":\"Q92769\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"PR domain zinc finger protein 4\",\"id\":\"Q9UKN5\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 16\",\"id\":\"P08138\"}]", "uniprot_id": "[\"O15379\",\"P01138\",\"P08138\",\"Q13547\",\"Q92769\",\"Q9UKN5\"]", "gene_symbol": "[\"HDAC1\",\"HDAC2\",\"HDAC3\",\"NGF\",\"NGFB\",\"NGFR\",\"PFM1\",\"PRDM4\",\"RPD3L1\",\"TNFRSF16\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "protein_name": 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polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"POU domain, class 2, transcription factor 1\",\"id\":\"P14859\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription factor IIIB 50 kDa subunit\",\"id\":\"Q9HAW0\"},{\"label\":\"Transcription factor TFIIIB component B'' homolog\",\"id\":\"A6H8Y1\"},{\"label\":\"Zinc finger protein 143\",\"id\":\"P52747\"},{\"label\":\"snRNA-activating protein complex subunit 1\",\"id\":\"Q16533\"},{\"label\":\"snRNA-activating protein complex subunit 2\",\"id\":\"Q13487\"},{\"label\":\"snRNA-activating protein complex subunit 3\",\"id\":\"Q92966\"},{\"label\":\"snRNA-activating protein complex subunit 4\",\"id\":\"Q5SXM2\"},{\"label\":\"snRNA-activating protein complex subunit 5\",\"id\":\"O75971\"}]", "uniprot_id": "[\"A6H8Y1\",\"O14802\",\"O15160\",\"O15318\",\"O75575\",\"O75971\",\"P05423\",\"P0DPB5\",\"P14859\",\"P19388\",\"P20226\",\"P52434\",\"P52747\",\"P53803\",\"P61218\",\"P62875\",\"Q13487\",\"Q16533\",\"Q5SXM2\",\"Q92966\",\"Q9BT43\",\"Q9BUI4\",\"Q9H1D9\",\"Q9HAW0\",\"Q9NVU0\",\"Q9NW08\",\"Q9Y2Y1\",\"Q9Y535\"]", "gene_symbol": 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subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O15169\",\"P25054\",\"P30153\",\"P30154\",\"P48729\",\"P49841\",\"P62714\",\"P67775\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\"]", "gene_symbol": "[\"AMER1\",\"APC\",\"AXIN\",\"AXIN1\",\"CSNK1A1\",\"DP2.5\",\"FAM123B\",\"GSK3B\",\"KIAA0044\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"WTX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Opioid Signalling", "protein_name": "[{\"label\":\"Mu-type opioid receptor\",\"id\":\"P35372\"},{\"label\":\"Pro-opiomelanocortin\",\"id\":\"P01189\"},{\"label\":\"Proenkephalin-B\",\"id\":\"P01213\"}]", "uniprot_id": "[\"P01189\",\"P01213\",\"P35372\"]", "gene_symbol": "[\"MOR1\",\"OPRM1\",\"PDYN\",\"POMC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "VEGFA-VEGFR2 Pathway", "protein_name": "[{\"label\":\"Abl interactor 1\",\"id\":\"Q8IZP0\"},{\"label\":\"Abl interactor 2\",\"id\":\"Q9NYB9\"},{\"label\":\"Actin-binding protein WASF1\",\"id\":\"Q92558\"},{\"label\":\"Actin-binding protein WASF2\",\"id\":\"Q9Y6W5\"},{\"label\":\"Actin-binding protein WASF3\",\"id\":\"Q9UPY6\"},{\"label\":\"Adapter molecule crk\",\"id\":\"P46108\"},{\"label\":\"BAR/IMD domain-containing adapter protein 2\",\"id\":\"Q9UQB8\"},{\"label\":\"Breast cancer anti-estrogen resistance protein 1\",\"id\":\"P56945\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Cytochrome b-245 heavy chain\",\"id\":\"P04839\"},{\"label\":\"Cytochrome b-245 light chain\",\"id\":\"P13498\"},{\"label\":\"Cytoplasmic FMR1-interacting protein 1\",\"id\":\"Q7L576\"},{\"label\":\"Cytoplasmic FMR1-interacting protein 2\",\"id\":\"Q96F07\"},{\"label\":\"Cytoplasmic protein NCK2\",\"id\":\"O43639\"},{\"label\":\"Dedicator of cytokinesis protein 1\",\"id\":\"Q14185\"},{\"label\":\"Engulfment and cell motility protein 1\",\"id\":\"Q92556\"},{\"label\":\"Engulfment and cell motility protein 2\",\"id\":\"Q96JJ3\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Guanine nucleotide exchange factor VAV3\",\"id\":\"Q9UKW4\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein beta-1\",\"id\":\"P04792\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"MAP kinase-activated protein kinase 2\",\"id\":\"P49137\"},{\"label\":\"MAP kinase-activated protein kinase 3\",\"id\":\"Q16644\"},{\"label\":\"Mitogen-activated protein kinase 11\",\"id\":\"Q15759\"},{\"label\":\"Mitogen-activated protein kinase 12\",\"id\":\"P53778\"},{\"label\":\"Mitogen-activated protein kinase 13\",\"id\":\"O15264\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Nck-associated protein 1-like\",\"id\":\"P55160\"},{\"label\":\"Nck-associated protein 1\",\"id\":\"Q9Y2A7\"},{\"label\":\"Neutrophil cytosol factor 1\",\"id\":\"P14598\"},{\"label\":\"Neutrophil cytosol factor 2\",\"id\":\"P19878\"},{\"label\":\"Neutrophil cytosol factor 4\",\"id\":\"Q15080\"},{\"label\":\"Paxillin\",\"id\":\"P49023\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Protein BRICK1\",\"id\":\"Q8WUW1\"},{\"label\":\"Protein-tyrosine kinase 2-beta\",\"id\":\"Q14289\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Rho-associated protein kinase 1\",\"id\":\"Q13464\"},{\"label\":\"Rho-associated protein kinase 2\",\"id\":\"O75116\"},{\"label\":\"SH2 domain-containing adapter protein B\",\"id\":\"Q15464\"},{\"label\":\"SH2 domain-containing protein 2A\",\"id\":\"Q9NP31\"},{\"label\":\"SH2/SH3 adapter protein NCK1\",\"id\":\"P16333\"},{\"label\":\"SHC-transforming protein 2\",\"id\":\"P98077\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase receptor UFO\",\"id\":\"P30530\"},{\"label\":\"Vascular endothelial growth factor receptor 2\",\"id\":\"P35968\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway", "protein_name": "[{\"label\":\"DNA polymerase beta\",\"id\":\"P06746\"},{\"label\":\"DNA repair nuclease/redox regulator APEX1\",\"id\":\"P27695\"}]", "uniprot_id": "[\"P06746\",\"P27695\"]", "gene_symbol": "[\"APE\",\"APE1\",\"APEX\",\"APEX1\",\"APX\",\"HAP1\",\"POLB\",\"REF1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Toxicity of botulinum toxin type D (botD)", "protein_name": "[{\"label\":\"Botulinum neurotoxin type D\",\"id\":\"P19321\"},{\"label\":\"Synaptic vesicle glycoprotein 2A\",\"id\":\"Q7L0J3\"},{\"label\":\"Synaptic vesicle glycoprotein 2B\",\"id\":\"Q7L1I2\"},{\"label\":\"Synaptic vesicle glycoprotein 2C\",\"id\":\"Q496J9\"},{\"label\":\"Vesicle-associated membrane protein 1\",\"id\":\"P23763\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"}]", "uniprot_id": "[\"P19321\",\"P23763\",\"P63027\",\"Q496J9\",\"Q7L0J3\",\"Q7L1I2\"]", "gene_symbol": "[\"KIAA0735\",\"KIAA0736\",\"KIAA1054\",\"SV2A\",\"SV2B\",\"SV2C\",\"SYB1\",\"SYB2\",\"VAMP1\",\"VAMP2\",\"botD\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Macroautophagy", "protein_name": "[{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-1\",\"id\":\"Q13131\"},{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-2\",\"id\":\"P54646\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-1\",\"id\":\"Q9Y478\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-2\",\"id\":\"O43741\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-1\",\"id\":\"P54619\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-2\",\"id\":\"Q9UGJ0\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-3\",\"id\":\"Q9UGI9\"},{\"label\":\"Activating molecule in BECN1-regulated autophagy protein 1\",\"id\":\"Q9C0C7\"},{\"label\":\"Autophagy protein 5\",\"id\":\"Q9H1Y0\"},{\"label\":\"Autophagy-related protein 101\",\"id\":\"Q9BSB4\"},{\"label\":\"Autophagy-related protein 13\",\"id\":\"O75143\"},{\"label\":\"Autophagy-related protein 16-1\",\"id\":\"Q676U5\"},{\"label\":\"Autophagy-related protein 9A\",\"id\":\"Q7Z3C6\"},{\"label\":\"Autophagy-related protein 9B\",\"id\":\"Q674R7\"},{\"label\":\"Beclin 1-associated autophagy-related key regulator\",\"id\":\"Q6ZNE5\"},{\"label\":\"Beclin-1\",\"id\":\"Q14457\"},{\"label\":\"Charged multivesicular body protein 2a\",\"id\":\"O43633\"},{\"label\":\"Charged multivesicular body protein 2b\",\"id\":\"Q9UQN3\"},{\"label\":\"Charged multivesicular body protein 3\",\"id\":\"Q9Y3E7\"},{\"label\":\"Charged multivesicular body protein 4a\",\"id\":\"Q9BY43\"},{\"label\":\"Charged multivesicular body protein 4b\",\"id\":\"Q9H444\"},{\"label\":\"Charged multivesicular body protein 4c\",\"id\":\"Q96CF2\"},{\"label\":\"Charged multivesicular body protein 6\",\"id\":\"Q96FZ7\"},{\"label\":\"Charged multivesicular body protein 7\",\"id\":\"Q8WUX9\"},{\"label\":\"Cysteine protease ATG4A\",\"id\":\"Q8WYN0\"},{\"label\":\"Cysteine protease ATG4B\",\"id\":\"Q9Y4P1\"},{\"label\":\"Cysteine protease ATG4C\",\"id\":\"Q96DT6\"},{\"label\":\"Cysteine protease ATG4D\",\"id\":\"Q86TL0\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"GTP-binding protein Rheb\",\"id\":\"Q15382\"},{\"label\":\"Gamma-aminobutyric acid receptor-associated protein-like 1\",\"id\":\"Q9H0R8\"},{\"label\":\"Gamma-aminobutyric acid receptor-associated protein-like 2\",\"id\":\"P60520\"},{\"label\":\"Gamma-aminobutyric acid receptor-associated protein-like 3\",\"id\":\"Q9BY60\"},{\"label\":\"Gamma-aminobutyric acid receptor-associated protein\",\"id\":\"O95166\"},{\"label\":\"Hamartin\",\"id\":\"Q92574\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 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"gtc_id": "[\"\"]" }, { "pathway_label": "Resistance of ERBB2 KD mutants to osimertinib", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P04626\",\"P07900\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "protein_name": "[{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"Amyloid-beta precursor protein\",\"id\":\"P05067\"},{\"label\":\"Bcl-2-like protein 11\",\"id\":\"O43521\"},{\"label\":\"Calpain small subunit 1\",\"id\":\"P04632\"},{\"label\":\"Calpain 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6\",\"id\":\"P48023\"}]", "uniprot_id": "[\"O43521\",\"O43524\",\"P04179\",\"P04632\",\"P05067\",\"P05412\",\"P07384\",\"P17655\",\"P20700\",\"P20810\",\"P30304\",\"P30305\",\"P30307\",\"P32119\",\"P48023\",\"P62258\",\"Q00535\",\"Q06830\",\"Q08379\",\"Q15078\",\"Q96L46\"]", "gene_symbol": "[\"A4\",\"AD1\",\"APP\",\"APT1LG1\",\"BCL2L11\",\"BIM\",\"CANPL1\",\"CANPL2\",\"CAPN1\",\"CAPN2\",\"CAPN4\",\"CAPNS\",\"CAPNS1\",\"CAPNS2\",\"CAST\",\"CD95L\",\"CDC25A\",\"CDC25B\",\"CDC25C\",\"CDC25HU2\",\"CDK5\",\"CDK5R\",\"CDK5R1\",\"CDKN5\",\"FASL\",\"FASLG\",\"FKHRL1\",\"FOXO3\",\"FOXO3A\",\"GOLGA2\",\"JUN\",\"LMN2\",\"LMNB\",\"LMNB1\",\"NCK5A\",\"NKEFB\",\"PAGA\",\"PAGB\",\"PRDX1\",\"PRDX2\",\"PSSALRE\",\"SOD2\",\"TDPX1\",\"TDPX2\",\"TNFSF6\",\"YWHAE\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Loss-of-function mutations in DBT cause MSUD2", "protein_name": "[{\"label\":\"2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial\",\"id\":\"P12694\"},{\"label\":\"2-oxoisovalerate dehydrogenase subunit beta, mitochondrial\",\"id\":\"P21953\"},{\"label\":\"Dihydrolipoyl dehydrogenase, mitochondrial\",\"id\":\"P09622\"},{\"label\":\"Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial\",\"id\":\"P11182\"}]", "uniprot_id": "[\"P09622\",\"P11182\",\"P12694\",\"P21953\"]", "gene_symbol": "[\"BCATE2\",\"BCKDHA\",\"BCKDHB\",\"BCKDHE2\",\"DBT\",\"DLD\",\"GCSL\",\"LAD\",\"PHE3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PINK1-PRKN Mediated Mitophagy", "protein_name": "[{\"label\":\"Autophagy protein 5\",\"id\":\"Q9H1Y0\"},{\"label\":\"Autophagy-related protein 9A\",\"id\":\"Q7Z3C6\"},{\"label\":\"E3 ubiquitin-protein ligase parkin\",\"id\":\"O60260\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 3A\",\"id\":\"Q9H492\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 3B\",\"id\":\"Q9GZQ8\"},{\"label\":\"Mitochondrial import receptor subunit TOM20 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kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit 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elongation factor SPT5\",\"id\":\"O00267\"},{\"label\":\"mRNA cap guanine-N7 methyltransferase\",\"id\":\"O43148\"},{\"label\":\"mRNA-capping enzyme\",\"id\":\"O60942\"}]", "uniprot_id": "[\"O00267\",\"O15514\",\"O43148\",\"O60942\",\"P13984\",\"P18074\",\"P19387\",\"P19388\",\"P19447\",\"P24928\",\"P30876\",\"P32780\",\"P35269\",\"P36954\",\"P50613\",\"P51946\",\"P51948\",\"P52434\",\"P52435\",\"P53803\",\"P61218\",\"P62487\",\"P62875\",\"Q13888\",\"Q13889\",\"Q6ZYL4\",\"Q92759\"]", "gene_symbol": 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epsilon\",\"id\":\"Q14164\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Optineurin\",\"id\":\"Q96CV9\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Serine/threonine-protein kinase TBK1\",\"id\":\"Q9UHD2\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"TIR domain-containing adapter molecule 2\",\"id\":\"Q86XR7\"},{\"label\":\"TNF receptor-associated factor 3\",\"id\":\"Q13114\"},{\"label\":\"TRAF family member-associated NF-kappa-B activator\",\"id\":\"Q92844\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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mitogen-activated protein kinase kinase 4\",\"id\":\"P45985\"},{\"label\":\"F-box/WD repeat-containing protein 11\",\"id\":\"Q9UKB1\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 8\",\"id\":\"P41279\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"TNFAIP3-interacting protein 2\",\"id\":\"Q8NFZ5\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion 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5B\",\"id\":\"Q9UGL1\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Transcription factor AP-2 gamma\",\"id\":\"Q92754\"},{\"label\":\"Transcription factor AP-2-alpha\",\"id\":\"P05549\"}]", "uniprot_id": "[\"P01106\",\"P05549\",\"P38936\",\"Q92754\",\"Q9UGL1\"]", "gene_symbol": "[\"AP2TF\",\"BHLHE39\",\"CAP20\",\"CDKN1\",\"CDKN1A\",\"CIP1\",\"JARID1B\",\"KDM5B\",\"MDA6\",\"MYC\",\"PIC1\",\"PLU1\",\"RBBP2H1\",\"SDI1\",\"TFAP2\",\"TFAP2A\",\"TFAP2C\",\"WAF1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RHOT1 GTPase cycle", "protein_name": "[{\"label\":\"Mitochondrial Rho GTPase 1\",\"id\":\"Q8IXI2\"},{\"label\":\"Rap1 GTPase-GDP dissociation stimulator 1\",\"id\":\"P52306\"},{\"label\":\"Trafficking kinesin-binding protein 1\",\"id\":\"Q9UPV9\"},{\"label\":\"Trafficking kinesin-binding protein 2\",\"id\":\"O60296\"},{\"label\":\"Unconventional myosin-XIX\",\"id\":\"Q96H55\"}]", "uniprot_id": "[\"O60296\",\"P52306\",\"Q8IXI2\",\"Q96H55\",\"Q9UPV9\"]", "gene_symbol": "[\"ALS2CR3\",\"ARHT1\",\"KIAA0549\",\"KIAA1042\",\"MYO19\",\"MYOHD1\",\"OIP106\",\"RAP1GDS1\",\"RHOT1\",\"SMGGDS\",\"TRAK1\",\"TRAK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Collagen degradation", "protein_name": "[{\"label\":\"5-phosphohydroxy-L-lysine phospho-lyase\",\"id\":\"Q8IUZ5\"},{\"label\":\"72 kDa type IV collagenase\",\"id\":\"P08253\"},{\"label\":\"Cathepsin B\",\"id\":\"P07858\"},{\"label\":\"Cathepsin D\",\"id\":\"P07339\"},{\"label\":\"Cathepsin K\",\"id\":\"P43235\"},{\"label\":\"Collagen alpha-1(IX) chain\",\"id\":\"P20849\"},{\"label\":\"Collagen alpha-1(XII) chain\",\"id\":\"Q99715\"},{\"label\":\"Collagen alpha-1(XIII) chain\",\"id\":\"Q5TAT6\"},{\"label\":\"Collagen alpha-1(XIV) chain\",\"id\":\"Q05707\"},{\"label\":\"Collagen alpha-1(XIX) chain\",\"id\":\"Q14993\"},{\"label\":\"Collagen alpha-1(XV) chain\",\"id\":\"P39059\"},{\"label\":\"Collagen alpha-1(XVI) chain\",\"id\":\"Q07092\"},{\"label\":\"Collagen alpha-1(XVII) chain\",\"id\":\"Q9UMD9\"},{\"label\":\"Collagen alpha-1(XVIII) chain\",\"id\":\"P39060\"},{\"label\":\"Collagen alpha-1(XXIII) chain\",\"id\":\"Q86Y22\"},{\"label\":\"Collagen alpha-1(XXV) chain\",\"id\":\"Q9BXS0\"},{\"label\":\"Collagen alpha-1(XXVI) chain\",\"id\":\"Q96A83\"},{\"label\":\"Collagen alpha-2(IX) chain\",\"id\":\"Q14055\"},{\"label\":\"Collagen alpha-3(IX) chain\",\"id\":\"Q14050\"},{\"label\":\"Collagenase 3\",\"id\":\"P45452\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 10\",\"id\":\"O14672\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 17\",\"id\":\"P78536\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 9\",\"id\":\"Q13443\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Interstitial collagenase\",\"id\":\"P03956\"},{\"label\":\"Macrophage metalloelastase\",\"id\":\"P39900\"},{\"label\":\"Matrilysin\",\"id\":\"P09237\"},{\"label\":\"Matrix metalloproteinase-14\",\"id\":\"P50281\"},{\"label\":\"Matrix metalloproteinase-15\",\"id\":\"P51511\"},{\"label\":\"Matrix metalloproteinase-19\",\"id\":\"Q99542\"},{\"label\":\"Matrix metalloproteinase-20\",\"id\":\"O60882\"},{\"label\":\"Matrix metalloproteinase-9\",\"id\":\"P14780\"},{\"label\":\"Neutrophil collagenase\",\"id\":\"P22894\"},{\"label\":\"Neutrophil elastase\",\"id\":\"P08246\"},{\"label\":\"Procathepsin L\",\"id\":\"P07711\"},{\"label\":\"Stromelysin-1\",\"id\":\"P08254\"},{\"label\":\"Stromelysin-2\",\"id\":\"P09238\"},{\"label\":\"Stromelysin-3\",\"id\":\"P24347\"},{\"label\":\"Transmembrane protease serine 6\",\"id\":\"Q8IU80\"},{\"label\":\"Trypsin-2\",\"id\":\"P07478\"}]", "uniprot_id": 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epimerase, mitochondrial\",\"id\":\"Q96PE7\"},{\"label\":\"Methylmalonyl-CoA mutase, mitochondrial\",\"id\":\"P22033\"},{\"label\":\"Propionyl-CoA carboxylase alpha chain, mitochondrial\",\"id\":\"P05165\"},{\"label\":\"Propionyl-CoA carboxylase beta chain, mitochondrial\",\"id\":\"P05166\"}]", "uniprot_id": "[\"P05165\",\"P05166\",\"P22033\",\"Q8IVH4\",\"Q96PE7\"]", "gene_symbol": "[\"MCEE\",\"MMAA\",\"MMUT\",\"MUT\",\"PCCA\",\"PCCB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Presynaptic depolarization and calcium channel opening", "protein_name": "[{\"label\":\"Dihydropyridine receptor alpha 2 subunit\",\"id\":\"Q9UIU0\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-1\",\"id\":\"Q02641\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-2\",\"id\":\"Q08289\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-3\",\"id\":\"P54284\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-4\",\"id\":\"O00305\"},{\"label\":\"Voltage-dependent N-type calcium channel subunit alpha-1B\",\"id\":\"Q00975\"},{\"label\":\"Voltage-dependent P/Q-type calcium channel subunit alpha-1A\",\"id\":\"O00555\"},{\"label\":\"Voltage-dependent R-type calcium channel subunit alpha-1E\",\"id\":\"Q15878\"},{\"label\":\"Voltage-dependent calcium channel gamma-2 subunit\",\"id\":\"Q9Y698\"},{\"label\":\"Voltage-dependent calcium channel gamma-4 subunit\",\"id\":\"Q9UBN1\"},{\"label\":\"Voltage-dependent calcium channel subunit alpha-2/delta-2\",\"id\":\"Q9NY47\"},{\"label\":\"Voltage-dependent calcium channel subunit alpha-2/delta-3\",\"id\":\"Q8IZS8\"}]", "uniprot_id": "[\"O00305\",\"O00555\",\"P54284\",\"Q00975\",\"Q02641\",\"Q08289\",\"Q15878\",\"Q8IZS8\",\"Q9NY47\",\"Q9UBN1\",\"Q9UIU0\",\"Q9Y698\"]", "gene_symbol": "[\"CACH4\",\"CACH5\",\"CACH6\",\"CACN3\",\"CACNA1A\",\"CACNA1B\",\"CACNA1E\",\"CACNA2D1\",\"CACNA2D2\",\"CACNA2D3\",\"CACNB1\",\"CACNB2\",\"CACNB3\",\"CACNB4\",\"CACNG2\",\"CACNG4\",\"CACNL1A4\",\"CACNL1A5\",\"CACNL1A6\",\"CACNLB1\",\"CACNLB2\",\"CACNLB3\",\"CACNLB4\",\"KIAA0558\",\"MYSB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interaction With Cumulus Cells And The Zona Pellucida", "protein_name": "[{\"label\":\"Beta-1,4-galactosyltransferase 1\",\"id\":\"P15291\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 20\",\"id\":\"O43506\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 21\",\"id\":\"Q9UKJ8\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 2\",\"id\":\"Q99965\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 30\",\"id\":\"Q9UKF2\"},{\"label\":\"Hyaluronidase PH-20\",\"id\":\"P38567\"},{\"label\":\"Oviduct-specific glycoprotein\",\"id\":\"Q12889\"},{\"label\":\"Zona pellucida sperm-binding protein 1\",\"id\":\"P60852\"},{\"label\":\"Zona pellucida sperm-binding protein 2\",\"id\":\"Q05996\"},{\"label\":\"Zona pellucida sperm-binding protein 3\",\"id\":\"P21754\"},{\"label\":\"Zona pellucida sperm-binding protein 4\",\"id\":\"Q12836\"}]", "uniprot_id": "[\"O43506\",\"P15291\",\"P21754\",\"P38567\",\"P60852\",\"Q05996\",\"Q12836\",\"Q12889\",\"Q99965\",\"Q9UKF2\",\"Q9UKJ8\"]", "gene_symbol": "[\"ADAM2\",\"ADAM20\",\"ADAM21\",\"ADAM30\",\"B4GALT1\",\"FTNB\",\"GGTB2\",\"HYAL3\",\"MUC9\",\"OGP\",\"OVGP1\",\"PH20\",\"SPAM1\",\"ZP1\",\"ZP2\",\"ZP3\",\"ZP3A\",\"ZP3B\",\"ZP4\",\"ZPA\",\"ZPB\",\"ZPC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Adenosine P1 receptors", "protein_name": "[{\"label\":\"Adenosine receptor A1\",\"id\":\"P30542\"},{\"label\":\"Adenosine receptor A2a\",\"id\":\"P29274\"},{\"label\":\"Adenosine receptor A2b\",\"id\":\"P29275\"},{\"label\":\"Adenosine receptor A3\",\"id\":\"P0DMS8\"}]", "uniprot_id": "[\"P0DMS8\",\"P29274\",\"P29275\",\"P30542\"]", "gene_symbol": "[\"ADORA1\",\"ADORA2\",\"ADORA2A\",\"ADORA2B\",\"ADORA3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC5A2 causes renal glucosuria (GLYS1)", "protein_name": "[{\"label\":\"Sodium/glucose cotransporter 2\",\"id\":\"P31639\"}]", "uniprot_id": "[\"P31639\"]", "gene_symbol": "[\"SGLT2\",\"SLC5A2\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "WNT5A-dependent internalization of FZD4", "protein_name": "[{\"label\":\"AP-2 complex subunit alpha-1\",\"id\":\"O95782\"},{\"label\":\"AP-2 complex subunit alpha-2\",\"id\":\"O94973\"},{\"label\":\"AP-2 complex subunit beta\",\"id\":\"P63010\"},{\"label\":\"AP-2 complex subunit mu\",\"id\":\"Q96CW1\"},{\"label\":\"AP-2 complex subunit sigma\",\"id\":\"P53680\"},{\"label\":\"Beta-arrestin-2\",\"id\":\"P32121\"},{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Clathrin light chain A\",\"id\":\"P09496\"},{\"label\":\"Clathrin light chain B\",\"id\":\"P09497\"},{\"label\":\"Frizzled-4\",\"id\":\"Q9ULV1\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Protein kinase C beta type\",\"id\":\"P05771\"},{\"label\":\"Protein kinase C gamma type\",\"id\":\"P05129\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-2\",\"id\":\"O14641\"}]", "uniprot_id": "[\"O14641\",\"O94973\",\"O95782\",\"P05129\",\"P05771\",\"P09496\",\"P09497\",\"P17252\",\"P32121\",\"P41221\",\"P53680\",\"P63010\",\"Q00610\",\"Q96CW1\",\"Q9ULV1\"]", "gene_symbol": "[\"ADTAA\",\"ADTAB\",\"ADTB2\",\"AP17\",\"AP2A1\",\"AP2A2\",\"AP2B1\",\"AP2M1\",\"AP2S1\",\"ARB2\",\"ARR2\",\"ARRB2\",\"CLAPA1\",\"CLAPA2\",\"CLAPB1\",\"CLAPM1\",\"CLAPS2\",\"CLH17\",\"CLTA\",\"CLTB\",\"CLTC\",\"CLTCL2\",\"DVL2\",\"FZD4\",\"HIP9\",\"HYPJ\",\"KIAA0034\",\"KIAA0109\",\"KIAA0899\",\"PKCA\",\"PKCB\",\"PKCG\",\"PRKACA\",\"PRKCA\",\"PRKCB\",\"PRKCB1\",\"PRKCG\",\"WNT5A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activated NTRK3 signals through RAS", "protein_name": "[{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"NT-3 growth factor receptor\",\"id\":\"Q16288\"},{\"label\":\"Neurotrophin-3\",\"id\":\"P20783\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P20783\",\"Q07889\",\"Q16288\"]", "gene_symbol": "[\"HRAS\",\"HRAS1\",\"NRAS\",\"NTF3\",\"NTRK3\",\"SOS1\",\"TRKC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of 5-eicosatetraenoic acids", "protein_name": "[{\"label\":\"Arachidonate 5-lipoxygenase-activating protein\",\"id\":\"P20292\"},{\"label\":\"Glutathione peroxidase 1\",\"id\":\"P07203\"},{\"label\":\"Glutathione peroxidase 2\",\"id\":\"P18283\"},{\"label\":\"Leukotriene C4 synthase\",\"id\":\"Q16873\"},{\"label\":\"Phospholipid hydroperoxide glutathione peroxidase GPX4\",\"id\":\"P36969\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"},{\"label\":\"Serum paraoxonase/arylesterase 1\",\"id\":\"P27169\"},{\"label\":\"Serum paraoxonase/arylesterase 2\",\"id\":\"Q15165\"},{\"label\":\"Serum paraoxonase/lactonase 3\",\"id\":\"Q15166\"}]", "uniprot_id": "[\"P07203\",\"P09917\",\"P18283\",\"P20292\",\"P27169\",\"P36969\",\"Q15165\",\"Q15166\",\"Q16873\"]", "gene_symbol": "[\"ALOX5\",\"ALOX5AP\",\"FLAP\",\"GPX1\",\"GPX2\",\"GPX4\",\"LOG5\",\"LTC4S\",\"PON\",\"PON1\",\"PON2\",\"PON3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "WNT5A-dependent internalization of FZD2, FZD5 and ROR2", "protein_name": "[{\"label\":\"AP-2 complex subunit alpha-1\",\"id\":\"O95782\"},{\"label\":\"AP-2 complex subunit alpha-2\",\"id\":\"O94973\"},{\"label\":\"AP-2 complex subunit beta\",\"id\":\"P63010\"},{\"label\":\"AP-2 complex subunit mu\",\"id\":\"Q96CW1\"},{\"label\":\"AP-2 complex subunit sigma\",\"id\":\"P53680\"},{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Clathrin light chain A\",\"id\":\"P09496\"},{\"label\":\"Clathrin light chain B\",\"id\":\"P09497\"},{\"label\":\"Frizzled-2\",\"id\":\"Q14332\"},{\"label\":\"Frizzled-5\",\"id\":\"Q13467\"},{\"label\":\"Inactive tyrosine-protein kinase transmembrane receptor ROR1\",\"id\":\"Q01973\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Tyrosine-protein kinase transmembrane receptor ROR2\",\"id\":\"Q01974\"}]", "uniprot_id": "[\"O94973\",\"O95782\",\"P09496\",\"P09497\",\"P41221\",\"P53680\",\"P63010\",\"Q00610\",\"Q01973\",\"Q01974\",\"Q13467\",\"Q14332\",\"Q96CW1\"]", "gene_symbol": "[\"ADTAA\",\"ADTAB\",\"ADTB2\",\"AP17\",\"AP2A1\",\"AP2A2\",\"AP2B1\",\"AP2M1\",\"AP2S1\",\"C2orf31\",\"CLAPA1\",\"CLAPA2\",\"CLAPB1\",\"CLAPM1\",\"CLAPS2\",\"CLH17\",\"CLTA\",\"CLTB\",\"CLTC\",\"CLTCL2\",\"FZD2\",\"FZD5\",\"HIP9\",\"HYPJ\",\"KIAA0034\",\"KIAA0109\",\"KIAA0899\",\"NTRKR1\",\"NTRKR2\",\"ROR1\",\"ROR2\",\"WNT5A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Resistance of ERBB2 KD mutants to lapatinib", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P04626\",\"P07900\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activated NTRK2 signals through RAS", "protein_name": "[{\"label\":\"BDNF/NT-3 growth factors receptor\",\"id\":\"Q16620\"},{\"label\":\"Brain-derived neurotrophic factor\",\"id\":\"P23560\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Neurotrophin-4\",\"id\":\"P34130\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P23560\",\"P34130\",\"Q07889\",\"Q16620\"]", "gene_symbol": "[\"BDNF\",\"HRAS\",\"HRAS1\",\"NRAS\",\"NTF4\",\"NTF5\",\"NTRK2\",\"SOS1\",\"TRKB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "trans-Golgi Network Vesicle Budding", "protein_name": "[{\"label\":\"ADP-ribosylation factor 1\",\"id\":\"P84077\"},{\"label\":\"Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1\",\"id\":\"Q92538\"},{\"label\":\"Synaptosomal-associated protein 23\",\"id\":\"O00161\"},{\"label\":\"Syntaxin-4\",\"id\":\"Q12846\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"},{\"label\":\"Vesicle-associated membrane protein 7\",\"id\":\"P51809\"},{\"label\":\"Vesicle-associated membrane protein 8\",\"id\":\"Q9BV40\"}]", "uniprot_id": "[\"O00161\",\"P51809\",\"P63027\",\"P84077\",\"Q12846\",\"Q92538\",\"Q9BV40\"]", "gene_symbol": "[\"ARF1\",\"GBF1\",\"KIAA0248\",\"SNAP23\",\"STX4\",\"STX4A\",\"SYB2\",\"SYBL1\",\"VAMP2\",\"VAMP7\",\"VAMP8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by FLT3 ITD and TKD mutants", "protein_name": "[{\"label\":\"GRB2-associated-binding protein 2\",\"id\":\"Q9UQC2\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Growth factor receptor-bound protein 2\",\"id\":\"P62993\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P27986\",\"P36888\",\"P42336\",\"P62993\",\"Q06124\",\"Q07889\",\"Q9UQC2\"]", "gene_symbol": "[\"ASH\",\"CD135\",\"FLK2\",\"FLT3\",\"GAB2\",\"GRB1\",\"GRB2\",\"HRAS\",\"HRAS1\",\"KIAA0571\",\"NRAS\",\"PIK3CA\",\"PIK3R1\",\"PTP2C\",\"PTPN11\",\"SHPTP2\",\"SOS1\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RHO GTPases activate CIT", "protein_name": "[{\"label\":\"Citron Rho-interacting kinase\",\"id\":\"O14578\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Kinesin-like protein KIF14\",\"id\":\"Q15058\"},{\"label\":\"Myosin light polypeptide 6\",\"id\":\"P60660\"},{\"label\":\"Myosin regulatory light chain 12B\",\"id\":\"O14950\"},{\"label\":\"Myosin regulatory light polypeptide 9\",\"id\":\"P24844\"},{\"label\":\"Myosin-10\",\"id\":\"P35580\"},{\"label\":\"Myosin-11\",\"id\":\"P35749\"},{\"label\":\"Myosin-14\",\"id\":\"Q7Z406\"},{\"label\":\"Myosin-9\",\"id\":\"P35579\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 12A\",\"id\":\"O14974\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 12B\",\"id\":\"O60237\"},{\"label\":\"Protein regulator of cytokinesis 1\",\"id\":\"O43663\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Rho-related GTP-binding protein RhoB\",\"id\":\"P62745\"},{\"label\":\"Rho-related GTP-binding protein RhoC\",\"id\":\"P08134\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-beta catalytic subunit\",\"id\":\"P62140\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"}]", "uniprot_id": "[\"O14578\",\"O14950\",\"O14974\",\"O43663\",\"O60237\",\"P08134\",\"P24844\",\"P35579\",\"P35580\",\"P35749\",\"P46527\",\"P60660\",\"P61586\",\"P62140\",\"P62745\",\"P63000\",\"P78352\",\"Q15058\",\"Q7Z406\"]", "gene_symbol": "[\"ARH12\",\"ARH6\",\"ARH9\",\"ARHA\",\"ARHB\",\"ARHC\",\"CDKN1B\",\"CIT\",\"CRIK\",\"DLG4\",\"KIAA0042\",\"KIAA0866\",\"KIAA0949\",\"KIAA2034\",\"KIF14\",\"KIP1\",\"MBS\",\"MLC2\",\"MRLC1\",\"MRLC2\",\"MYH10\",\"MYH11\",\"MYH14\",\"MYH9\",\"MYL12B\",\"MYL6\",\"MYL9\",\"MYLC2B\",\"MYPT1\",\"MYPT2\",\"MYRL2\",\"PPP1CB\",\"PPP1R12A\",\"PPP1R12B\",\"PRC1\",\"PSD95\",\"RAC1\",\"RHO12\",\"RHOA\",\"RHOB\",\"RHOC\",\"STK21\",\"TC25\",\"p27\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Generic Transcription Pathway", "protein_name": "[{\"label\":\"Cyclin-C\",\"id\":\"P24863\"},{\"label\":\"Cyclin-dependent kinase 8\",\"id\":\"P49336\"},{\"label\":\"Endothelial zinc finger protein induced by tumor necrosis factor alpha\",\"id\":\"Q9NQZ8\"},{\"label\":\"Histone-lysine N-methyltransferase PRDM7\",\"id\":\"Q9NQW5\"},{\"label\":\"KRAB domain-containing protein 4\",\"id\":\"Q5JUW0\"},{\"label\":\"KRAB domain-containing protein 5\",\"id\":\"Q7Z2F6\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 10\",\"id\":\"Q9BTT4\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 12\",\"id\":\"Q93074\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 13\",\"id\":\"Q9UHV7\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 14\",\"id\":\"O60244\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 15\",\"id\":\"Q96RN5\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 16\",\"id\":\"Q9Y2X0\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 17\",\"id\":\"Q9NVC6\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 1\",\"id\":\"Q15648\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 20\",\"id\":\"Q9H944\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 23\",\"id\":\"Q9ULK4\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 24\",\"id\":\"O75448\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 25\",\"id\":\"Q71SY5\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 26\",\"id\":\"O95402\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 27\",\"id\":\"Q6P2C8\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 30\",\"id\":\"Q96HR3\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 31\",\"id\":\"Q9Y3C7\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 4\",\"id\":\"Q9NPJ6\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 6\",\"id\":\"O75586\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 7\",\"id\":\"O43513\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 8\",\"id\":\"Q96G25\"},{\"label\":\"Neurotrophin receptor-interacting factor homolog\",\"id\":\"Q96GC6\"},{\"label\":\"Protein KRBA1\",\"id\":\"A5PL33\"},{\"label\":\"Protein ZNF767\",\"id\":\"Q75MW2\"},{\"label\":\"Putative zinc finger protein 702\",\"id\":\"Q9H963\"},{\"label\":\"Putative zinc finger protein 705EP\",\"id\":\"A8MWA4\"},{\"label\":\"Putative zinc finger protein 705G\",\"id\":\"A8MUZ8\"},{\"label\":\"Putative zinc finger protein 726P1\",\"id\":\"Q15940\"},{\"label\":\"Putative zinc finger protein 727\",\"id\":\"A8MUV8\"},{\"label\":\"Putative zinc finger protein 730\",\"id\":\"Q6ZMV8\"},{\"label\":\"Putative zinc finger protein 735\",\"id\":\"P0CB33\"},{\"label\":\"Putative zinc finger protein 75C\",\"id\":\"Q92670\"},{\"label\":\"Putative zinc finger protein 840\",\"id\":\"A6NDX5\"},{\"label\":\"Transcription intermediary factor 1-beta\",\"id\":\"Q13263\"},{\"label\":\"Transcriptional repressor RHIT\",\"id\":\"O95201\"},{\"label\":\"Zinc finger and SCAN domain-containing protein 25\",\"id\":\"Q6NSZ9\"},{\"label\":\"Zinc finger and SCAN domain-containing protein 32\",\"id\":\"Q9NX65\"},{\"label\":\"Zinc finger imprinted 2\",\"id\":\"Q9NZV7\"},{\"label\":\"Zinc finger imprinted 3\",\"id\":\"Q96PE6\"},{\"label\":\"Zinc finger protein 1 homolog\",\"id\":\"Q6P2D0\"},{\"label\":\"Zinc finger protein 100\",\"id\":\"Q8IYN0\"},{\"label\":\"Zinc finger protein 101\",\"id\":\"Q8IZC7\"},{\"label\":\"Zinc finger protein 10\",\"id\":\"P21506\"},{\"label\":\"Zinc finger protein 112\",\"id\":\"Q9UJU3\"},{\"label\":\"Zinc finger protein 114\",\"id\":\"Q8NC26\"},{\"label\":\"Zinc finger protein 124\",\"id\":\"Q15973\"},{\"label\":\"Zinc finger protein 12\",\"id\":\"P17014\"},{\"label\":\"Zinc finger protein 133\",\"id\":\"P52736\"},{\"label\":\"Zinc finger protein 135\",\"id\":\"P52742\"},{\"label\":\"Zinc finger protein 136\",\"id\":\"P52737\"},{\"label\":\"Zinc finger protein 138\",\"id\":\"P52744\"},{\"label\":\"Zinc finger protein 14 homolog\",\"id\":\"Q9HCL3\"},{\"label\":\"Zinc finger protein 140\",\"id\":\"P52738\"},{\"label\":\"Zinc finger protein 141\",\"id\":\"Q15928\"},{\"label\":\"Zinc finger protein 14\",\"id\":\"P17017\"},{\"label\":\"Zinc finger protein 154\",\"id\":\"Q13106\"},{\"label\":\"Zinc finger protein 155\",\"id\":\"Q12901\"},{\"label\":\"Zinc finger protein 157\",\"id\":\"P51786\"},{\"label\":\"Zinc finger protein 160\",\"id\":\"Q9HCG1\"},{\"label\":\"Zinc finger protein 169\",\"id\":\"Q14929\"},{\"label\":\"Zinc finger protein 175\",\"id\":\"Q9Y473\"},{\"label\":\"Zinc finger protein 17\",\"id\":\"P17021\"},{\"label\":\"Zinc finger protein 180\",\"id\":\"Q9UJW8\"},{\"label\":\"Zinc finger protein 184\",\"id\":\"Q99676\"},{\"label\":\"Zinc finger protein 189\",\"id\":\"O75820\"},{\"label\":\"Zinc finger protein 18\",\"id\":\"P17022\"},{\"label\":\"Zinc finger protein 195\",\"id\":\"O14628\"},{\"label\":\"Zinc finger protein 197\",\"id\":\"O14709\"},{\"label\":\"Zinc finger protein 19\",\"id\":\"P17023\"},{\"label\":\"Zinc finger protein 200\",\"id\":\"P98182\"},{\"label\":\"Zinc finger protein 202\",\"id\":\"O95125\"},{\"label\":\"Zinc finger protein 208\",\"id\":\"O43345\"},{\"label\":\"Zinc finger protein 20\",\"id\":\"P17024\"},{\"label\":\"Zinc finger protein 211\",\"id\":\"Q13398\"},{\"label\":\"Zinc finger protein 212\",\"id\":\"Q9UDV6\"},{\"label\":\"Zinc finger protein 213\",\"id\":\"O14771\"},{\"label\":\"Zinc finger protein 214\",\"id\":\"Q9UL59\"},{\"label\":\"Zinc finger protein 215\",\"id\":\"Q9UL58\"},{\"label\":\"Zinc finger protein 221\",\"id\":\"Q9UK13\"},{\"label\":\"Zinc finger protein 222\",\"id\":\"Q9UK12\"},{\"label\":\"Zinc finger protein 223\",\"id\":\"Q9UK11\"},{\"label\":\"Zinc finger protein 224\",\"id\":\"Q9NZL3\"},{\"label\":\"Zinc finger protein 225\",\"id\":\"Q9UK10\"},{\"label\":\"Zinc finger protein 226\",\"id\":\"Q9NYT6\"},{\"label\":\"Zinc finger protein 227\",\"id\":\"Q86WZ6\"},{\"label\":\"Zinc finger protein 230\",\"id\":\"Q9UIE0\"},{\"label\":\"Zinc finger protein 233\",\"id\":\"A6NK53\"},{\"label\":\"Zinc finger protein 234\",\"id\":\"Q14588\"},{\"label\":\"Zinc finger protein 235\",\"id\":\"Q14590\"},{\"label\":\"Zinc finger protein 23\",\"id\":\"P17027\"},{\"label\":\"Zinc finger protein 248\",\"id\":\"Q8NDW4\"},{\"label\":\"Zinc finger protein 250\",\"id\":\"P15622\"},{\"label\":\"Zinc finger protein 253\",\"id\":\"O75346\"},{\"label\":\"Zinc finger protein 254\",\"id\":\"O75437\"},{\"label\":\"Zinc finger protein 256\",\"id\":\"Q9Y2P7\"},{\"label\":\"Zinc finger protein 257\",\"id\":\"Q9Y2Q1\"},{\"label\":\"Zinc finger protein 25\",\"id\":\"P17030\"},{\"label\":\"Zinc finger protein 263\",\"id\":\"O14978\"},{\"label\":\"Zinc finger protein 264\",\"id\":\"O43296\"},{\"label\":\"Zinc finger protein 266\",\"id\":\"Q14584\"},{\"label\":\"Zinc finger protein 267\",\"id\":\"Q14586\"},{\"label\":\"Zinc finger protein 268\",\"id\":\"Q14587\"},{\"label\":\"Zinc finger protein 26\",\"id\":\"P17031\"},{\"label\":\"Zinc finger protein 273\",\"id\":\"Q14593\"},{\"label\":\"Zinc finger protein 28 homolog\",\"id\":\"Q8NHY6\"},{\"label\":\"Zinc finger protein 282\",\"id\":\"Q9UDV7\"},{\"label\":\"Zinc finger protein 285\",\"id\":\"Q96NJ3\"},{\"label\":\"Zinc finger protein 286A\",\"id\":\"Q9HBT8\"},{\"label\":\"Zinc finger protein 287\",\"id\":\"Q9HBT7\"},{\"label\":\"Zinc finger protein 28\",\"id\":\"P17035\"},{\"label\":\"Zinc finger protein 2\",\"id\":\"Q9BSG1\"},{\"label\":\"Zinc finger protein 30 homolog\",\"id\":\"Q9Y2G7\"},{\"label\":\"Zinc finger protein 300\",\"id\":\"Q96RE9\"},{\"label\":\"Zinc finger protein 302\",\"id\":\"Q9NR11\"},{\"label\":\"Zinc finger protein 304\",\"id\":\"Q9HCX3\"},{\"label\":\"Zinc finger protein 30\",\"id\":\"P17039\"},{\"label\":\"Zinc finger protein 311\",\"id\":\"Q5JNZ3\"},{\"label\":\"Zinc finger protein 317\",\"id\":\"Q96PQ6\"},{\"label\":\"Zinc finger protein 320\",\"id\":\"A2RRD8\"},{\"label\":\"Zinc finger protein 324A\",\"id\":\"O75467\"},{\"label\":\"Zinc finger protein 324B\",\"id\":\"Q6AW86\"},{\"label\":\"Zinc finger protein 331\",\"id\":\"Q9NQX6\"},{\"label\":\"Zinc finger protein 333\",\"id\":\"Q96JL9\"},{\"label\":\"Zinc finger protein 334\",\"id\":\"Q9HCZ1\"},{\"label\":\"Zinc finger protein 337\",\"id\":\"Q9Y3M9\"},{\"label\":\"Zinc finger protein 33A\",\"id\":\"Q06730\"},{\"label\":\"Zinc finger protein 33B\",\"id\":\"Q06732\"},{\"label\":\"Zinc finger protein 343\",\"id\":\"Q6P1L6\"},{\"label\":\"Zinc finger protein 347\",\"id\":\"Q96SE7\"},{\"label\":\"Zinc finger protein 34\",\"id\":\"Q8IZ26\"},{\"label\":\"Zinc finger protein 350\",\"id\":\"Q9GZX5\"},{\"label\":\"Zinc finger protein 354A\",\"id\":\"O60765\"},{\"label\":\"Zinc finger protein 354B\",\"id\":\"Q96LW1\"},{\"label\":\"Zinc finger protein 354C\",\"id\":\"Q86Y25\"},{\"label\":\"Zinc finger protein 37 homolog\",\"id\":\"Q9Y6Q3\"},{\"label\":\"Zinc finger protein 37A\",\"id\":\"P17032\"},{\"label\":\"Zinc finger protein 382\",\"id\":\"Q96SR6\"},{\"label\":\"Zinc finger protein 383\",\"id\":\"Q8NA42\"},{\"label\":\"Zinc finger protein 394\",\"id\":\"Q53GI3\"},{\"label\":\"Zinc finger protein 398\",\"id\":\"Q8TD17\"},{\"label\":\"Zinc finger protein 3\",\"id\":\"P17036\"},{\"label\":\"Zinc finger protein 415\",\"id\":\"Q09FC8\"},{\"label\":\"Zinc finger protein 416\",\"id\":\"Q9BWM5\"},{\"label\":\"Zinc finger protein 417\",\"id\":\"Q8TAU3\"},{\"label\":\"Zinc finger protein 418\",\"id\":\"Q8TF45\"},{\"label\":\"Zinc finger protein 419\",\"id\":\"Q96HQ0\"},{\"label\":\"Zinc finger protein 41\",\"id\":\"P51814\"},{\"label\":\"Zinc finger protein 420\",\"id\":\"Q8TAQ5\"},{\"label\":\"Zinc finger protein 425\",\"id\":\"Q6IV72\"},{\"label\":\"Zinc finger protein 426\",\"id\":\"Q9BUY5\"},{\"label\":\"Zinc finger protein 429\",\"id\":\"Q86V71\"},{\"label\":\"Zinc finger protein 430\",\"id\":\"Q9H8G1\"},{\"label\":\"Zinc finger protein 431\",\"id\":\"Q8TF32\"},{\"label\":\"Zinc finger protein 432\",\"id\":\"O94892\"},{\"label\":\"Zinc finger protein 433\",\"id\":\"Q8N7K0\"},{\"label\":\"Zinc finger protein 436\",\"id\":\"Q9C0F3\"},{\"label\":\"Zinc finger protein 439\",\"id\":\"Q8NDP4\"},{\"label\":\"Zinc finger protein 43\",\"id\":\"P17038\"},{\"label\":\"Zinc finger protein 440\",\"id\":\"Q8IYI8\"},{\"label\":\"Zinc finger protein 441\",\"id\":\"Q8N8Z8\"},{\"label\":\"Zinc finger protein 442\",\"id\":\"Q9H7R0\"},{\"label\":\"Zinc finger protein 443\",\"id\":\"Q9Y2A4\"},{\"label\":\"Zinc finger protein 445\",\"id\":\"P59923\"},{\"label\":\"Zinc finger protein 446\",\"id\":\"Q9NWS9\"},{\"label\":\"Zinc finger protein 454\",\"id\":\"Q8N9F8\"},{\"label\":\"Zinc finger protein 45\",\"id\":\"Q02386\"},{\"label\":\"Zinc finger protein 460\",\"id\":\"Q14592\"},{\"label\":\"Zinc finger protein 461\",\"id\":\"Q8TAF7\"},{\"label\":\"Zinc finger protein 468\",\"id\":\"Q5VIY5\"},{\"label\":\"Zinc finger protein 470\",\"id\":\"Q6ECI4\"},{\"label\":\"Zinc finger protein 471\",\"id\":\"Q9BX82\"},{\"label\":\"Zinc finger protein 473\",\"id\":\"Q8WTR7\"},{\"label\":\"Zinc finger protein 479\",\"id\":\"Q96JC4\"},{\"label\":\"Zinc finger protein 480\",\"id\":\"Q8WV37\"},{\"label\":\"Zinc finger protein 483\",\"id\":\"Q8TF39\"},{\"label\":\"Zinc finger protein 484\",\"id\":\"Q5JVG2\"},{\"label\":\"Zinc finger protein 485\",\"id\":\"Q8NCK3\"},{\"label\":\"Zinc finger protein 486\",\"id\":\"Q96H40\"},{\"label\":\"Zinc finger protein 490\",\"id\":\"Q9ULM2\"},{\"label\":\"Zinc finger protein 492\",\"id\":\"Q9P255\"},{\"label\":\"Zinc finger protein 493\",\"id\":\"Q6ZR52\"},{\"label\":\"Zinc finger protein 496\",\"id\":\"Q96IT1\"},{\"label\":\"Zinc finger protein 500\",\"id\":\"O60304\"},{\"label\":\"Zinc finger protein 506\",\"id\":\"Q5JVG8\"},{\"label\":\"Zinc finger protein 510\",\"id\":\"Q9Y2H8\"},{\"label\":\"Zinc finger protein 514\",\"id\":\"Q96K75\"},{\"label\":\"Zinc finger protein 517\",\"id\":\"Q6ZMY9\"},{\"label\":\"Zinc finger protein 519\",\"id\":\"Q8TB69\"},{\"label\":\"Zinc finger protein 528\",\"id\":\"Q3MIS6\"},{\"label\":\"Zinc finger protein 529\",\"id\":\"Q6P280\"},{\"label\":\"Zinc finger protein 530\",\"id\":\"Q6P9A1\"},{\"label\":\"Zinc finger protein 540\",\"id\":\"Q8NDQ6\"},{\"label\":\"Zinc finger protein 543\",\"id\":\"Q08ER8\"},{\"label\":\"Zinc finger protein 544\",\"id\":\"Q6NX49\"},{\"label\":\"Zinc finger protein 546\",\"id\":\"Q86UE3\"},{\"label\":\"Zinc finger protein 547\",\"id\":\"Q8IVP9\"},{\"label\":\"Zinc finger protein 548\",\"id\":\"Q8NEK5\"},{\"label\":\"Zinc finger protein 549\",\"id\":\"Q6P9A3\"},{\"label\":\"Zinc finger protein 550\",\"id\":\"Q7Z398\"},{\"label\":\"Zinc finger protein 551\",\"id\":\"Q7Z340\"},{\"label\":\"Zinc finger protein 552\",\"id\":\"Q9H707\"},{\"label\":\"Zinc finger protein 554\",\"id\":\"Q86TJ5\"},{\"label\":\"Zinc finger protein 555\",\"id\":\"Q8NEP9\"},{\"label\":\"Zinc finger protein 556\",\"id\":\"Q9HAH1\"},{\"label\":\"Zinc finger protein 557\",\"id\":\"Q8N988\"},{\"label\":\"Zinc finger protein 558\",\"id\":\"Q96NG5\"},{\"label\":\"Zinc finger protein 559\",\"id\":\"Q9BR84\"},{\"label\":\"Zinc finger protein 560\",\"id\":\"Q96MR9\"},{\"label\":\"Zinc finger protein 561\",\"id\":\"Q8N587\"},{\"label\":\"Zinc finger protein 562\",\"id\":\"Q6V9R5\"},{\"label\":\"Zinc finger protein 563\",\"id\":\"Q8TA94\"},{\"label\":\"Zinc finger protein 564\",\"id\":\"Q8TBZ8\"},{\"label\":\"Zinc finger protein 565\",\"id\":\"Q8N9K5\"},{\"label\":\"Zinc finger protein 566\",\"id\":\"Q969W8\"},{\"label\":\"Zinc finger protein 567\",\"id\":\"Q8N184\"},{\"label\":\"Zinc finger protein 568\",\"id\":\"Q3ZCX4\"},{\"label\":\"Zinc finger protein 569\",\"id\":\"Q5MCW4\"},{\"label\":\"Zinc finger protein 570\",\"id\":\"Q96NI8\"},{\"label\":\"Zinc finger protein 571\",\"id\":\"Q7Z3V5\"},{\"label\":\"Zinc finger protein 573\",\"id\":\"Q86YE8\"},{\"label\":\"Zinc finger protein 577\",\"id\":\"Q9BSK1\"},{\"label\":\"Zinc finger protein 582\",\"id\":\"Q96NG8\"},{\"label\":\"Zinc finger protein 583\",\"id\":\"Q96ND8\"},{\"label\":\"Zinc finger protein 584\",\"id\":\"Q8IVC4\"},{\"label\":\"Zinc finger protein 585A\",\"id\":\"Q6P3V2\"},{\"label\":\"Zinc finger protein 585B\",\"id\":\"Q52M93\"},{\"label\":\"Zinc finger protein 586\",\"id\":\"Q9NXT0\"},{\"label\":\"Zinc finger protein 587\",\"id\":\"Q96SQ5\"},{\"label\":\"Zinc finger protein 589\",\"id\":\"Q86UQ0\"},{\"label\":\"Zinc finger protein 595\",\"id\":\"Q8IYB9\"},{\"label\":\"Zinc finger protein 596\",\"id\":\"Q8TC21\"},{\"label\":\"Zinc finger protein 597\",\"id\":\"Q96LX8\"},{\"label\":\"Zinc finger protein 599\",\"id\":\"Q96NL3\"},{\"label\":\"Zinc finger protein 600\",\"id\":\"Q6ZNG1\"},{\"label\":\"Zinc finger protein 605\",\"id\":\"Q86T29\"},{\"label\":\"Zinc finger protein 606\",\"id\":\"Q8WXB4\"},{\"label\":\"Zinc finger protein 607\",\"id\":\"Q96SK3\"},{\"label\":\"Zinc finger protein 610\",\"id\":\"Q8N9Z0\"},{\"label\":\"Zinc finger protein 611\",\"id\":\"Q8N823\"},{\"label\":\"Zinc finger protein 613\",\"id\":\"Q6PF04\"},{\"label\":\"Zinc finger protein 614\",\"id\":\"Q8N883\"},{\"label\":\"Zinc finger protein 615\",\"id\":\"Q8N8J6\"},{\"label\":\"Zinc finger protein 616\",\"id\":\"Q08AN1\"},{\"label\":\"Zinc finger protein 619\",\"id\":\"Q8N2I2\"},{\"label\":\"Zinc finger protein 620\",\"id\":\"Q6ZNG0\"},{\"label\":\"Zinc finger protein 621\",\"id\":\"Q6ZSS3\"},{\"label\":\"Zinc finger protein 624\",\"id\":\"Q9P2J8\"},{\"label\":\"Zinc finger protein 625\",\"id\":\"Q96I27\"},{\"label\":\"Zinc finger protein 626\",\"id\":\"Q68DY1\"},{\"label\":\"Zinc finger protein 627\",\"id\":\"Q7L945\"},{\"label\":\"Zinc finger protein 641\",\"id\":\"Q96N77\"},{\"label\":\"Zinc finger protein 649\",\"id\":\"Q9BS31\"},{\"label\":\"Zinc finger protein 655\",\"id\":\"Q8N720\"},{\"label\":\"Zinc finger protein 658\",\"id\":\"Q5TYW1\"},{\"label\":\"Zinc finger protein 658B\",\"id\":\"Q4V348\"},{\"label\":\"Zinc finger protein 660\",\"id\":\"Q6AZW8\"},{\"label\":\"Zinc finger protein 662\",\"id\":\"Q6ZS27\"},{\"label\":\"Zinc finger protein 664\",\"id\":\"Q8N3J9\"},{\"label\":\"Zinc finger protein 665\",\"id\":\"Q9H7R5\"},{\"label\":\"Zinc finger protein 667\",\"id\":\"Q5HYK9\"},{\"label\":\"Zinc finger protein 668\",\"id\":\"Q96K58\"},{\"label\":\"Zinc finger protein 669\",\"id\":\"Q96BR6\"},{\"label\":\"Zinc finger protein 670\",\"id\":\"Q9BS34\"},{\"label\":\"Zinc finger protein 671\",\"id\":\"Q8TAW3\"},{\"label\":\"Zinc finger protein 675\",\"id\":\"Q8TD23\"},{\"label\":\"Zinc finger protein 676\",\"id\":\"Q8N7Q3\"},{\"label\":\"Zinc finger protein 677\",\"id\":\"Q86XU0\"},{\"label\":\"Zinc finger protein 678\",\"id\":\"Q5SXM1\"},{\"label\":\"Zinc finger protein 679\",\"id\":\"Q8IYX0\"},{\"label\":\"Zinc finger protein 680\",\"id\":\"Q8NEM1\"},{\"label\":\"Zinc finger protein 681\",\"id\":\"Q96N22\"},{\"label\":\"Zinc finger protein 682\",\"id\":\"O95780\"},{\"label\":\"Zinc finger protein 684\",\"id\":\"Q5T5D7\"},{\"label\":\"Zinc finger protein 688\",\"id\":\"P0C7X2\"},{\"label\":\"Zinc finger protein 689\",\"id\":\"Q96CS4\"},{\"label\":\"Zinc finger protein 69 homolog B\",\"id\":\"Q9UJL9\"},{\"label\":\"Zinc finger protein 69 homolog\",\"id\":\"Q49AA0\"},{\"label\":\"Zinc finger protein 691\",\"id\":\"Q5VV52\"},{\"label\":\"Zinc finger protein 692\",\"id\":\"Q9BU19\"},{\"label\":\"Zinc finger protein 696\",\"id\":\"Q9H7X3\"},{\"label\":\"Zinc finger protein 697\",\"id\":\"Q5TEC3\"},{\"label\":\"Zinc finger protein 699\",\"id\":\"Q32M78\"},{\"label\":\"Zinc finger protein 700\",\"id\":\"Q9H0M5\"},{\"label\":\"Zinc finger protein 701\",\"id\":\"Q9NV72\"},{\"label\":\"Zinc finger protein 703\",\"id\":\"Q9H7S9\"},{\"label\":\"Zinc finger protein 704\",\"id\":\"Q6ZNC4\"},{\"label\":\"Zinc finger protein 705A\",\"id\":\"Q6ZN79\"},{\"label\":\"Zinc finger protein 705D\",\"id\":\"P0CH99\"},{\"label\":\"Zinc finger protein 706\",\"id\":\"Q9Y5V0\"},{\"label\":\"Zinc finger protein 707\",\"id\":\"Q96C28\"},{\"label\":\"Zinc finger protein 708\",\"id\":\"P17019\"},{\"label\":\"Zinc finger protein 709\",\"id\":\"Q8N972\"},{\"label\":\"Zinc finger protein 70\",\"id\":\"Q9UC06\"},{\"label\":\"Zinc finger protein 710\",\"id\":\"Q8N1W2\"},{\"label\":\"Zinc finger protein 711\",\"id\":\"Q9Y462\"},{\"label\":\"Zinc finger protein 713\",\"id\":\"Q8N859\"},{\"label\":\"Zinc finger protein 714\",\"id\":\"Q96N38\"},{\"label\":\"Zinc finger protein 716\",\"id\":\"A6NP11\"},{\"label\":\"Zinc finger protein 717\",\"id\":\"Q9BY31\"},{\"label\":\"Zinc finger protein 718\",\"id\":\"Q3SXZ3\"},{\"label\":\"Zinc finger protein 721\",\"id\":\"Q8TF20\"},{\"label\":\"Zinc finger protein 724\",\"id\":\"A8MTY0\"},{\"label\":\"Zinc finger protein 726\",\"id\":\"A6NNF4\"},{\"label\":\"Zinc finger protein 729\",\"id\":\"A6NN14\"},{\"label\":\"Zinc finger protein 732\",\"id\":\"B4DXR9\"},{\"label\":\"Zinc finger protein 736\",\"id\":\"B4DX44\"},{\"label\":\"Zinc finger protein 737\",\"id\":\"O75373\"},{\"label\":\"Zinc finger protein 738\",\"id\":\"Q8NE65\"},{\"label\":\"Zinc finger protein 740\",\"id\":\"Q8NDX6\"},{\"label\":\"Zinc finger protein 746\",\"id\":\"Q6NUN9\"},{\"label\":\"Zinc finger protein 747\",\"id\":\"Q9BV97\"},{\"label\":\"Zinc finger protein 749\",\"id\":\"O43361\"},{\"label\":\"Zinc finger protein 74\",\"id\":\"Q16587\"},{\"label\":\"Zinc finger protein 750\",\"id\":\"Q32MQ0\"},{\"label\":\"Zinc finger protein 75A\",\"id\":\"Q96N20\"},{\"label\":\"Zinc finger protein 75D\",\"id\":\"P51815\"},{\"label\":\"Zinc finger protein 761\",\"id\":\"Q86XN6\"},{\"label\":\"Zinc finger protein 764\",\"id\":\"Q96H86\"},{\"label\":\"Zinc finger protein 770\",\"id\":\"Q6IQ21\"},{\"label\":\"Zinc finger protein 771\",\"id\":\"Q7L3S4\"},{\"label\":\"Zinc finger protein 772\",\"id\":\"Q68DY9\"},{\"label\":\"Zinc finger protein 773\",\"id\":\"Q6PK81\"},{\"label\":\"Zinc finger protein 774\",\"id\":\"Q6NX45\"},{\"label\":\"Zinc finger protein 775\",\"id\":\"Q96BV0\"},{\"label\":\"Zinc finger protein 776\",\"id\":\"Q68DI1\"},{\"label\":\"Zinc finger protein 777\",\"id\":\"Q9ULD5\"},{\"label\":\"Zinc finger protein 778\",\"id\":\"Q96MU6\"},{\"label\":\"Zinc finger protein 77\",\"id\":\"Q15935\"},{\"label\":\"Zinc finger protein 782\",\"id\":\"Q6ZMW2\"},{\"label\":\"Zinc finger protein 785\",\"id\":\"A8K8V0\"},{\"label\":\"Zinc finger protein 786\",\"id\":\"Q8N393\"},{\"label\":\"Zinc finger protein 790\",\"id\":\"Q6PG37\"},{\"label\":\"Zinc finger protein 791\",\"id\":\"Q3KP31\"},{\"label\":\"Zinc finger protein 792\",\"id\":\"Q3KQV3\"},{\"label\":\"Zinc finger protein 793\",\"id\":\"Q6ZN11\"},{\"label\":\"Zinc finger protein 799\",\"id\":\"Q96GE5\"},{\"label\":\"Zinc finger protein 79\",\"id\":\"Q15937\"},{\"label\":\"Zinc finger protein 804B\",\"id\":\"A4D1E1\"},{\"label\":\"Zinc finger protein 839\",\"id\":\"A8K0R7\"},{\"label\":\"Zinc finger protein 860\",\"id\":\"A6NHJ4\"},{\"label\":\"Zinc finger protein 875\",\"id\":\"P10072\"},{\"label\":\"Zinc finger protein 90 homolog\",\"id\":\"Q8TF47\"},{\"label\":\"Zinc finger protein 92\",\"id\":\"Q03936\"},{\"label\":\"Zinc finger protein 99\",\"id\":\"A8MXY4\"},{\"label\":\"Zinc finger protein ZFP2\",\"id\":\"Q6ZN57\"},{\"label\":\"Zinc finger protein 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protein\",\"id\":\"O94777\"},{\"label\":\"Dolichol-phosphate mannosyltransferase subunit 1\",\"id\":\"O60762\"},{\"label\":\"Dolichol-phosphate mannosyltransferase subunit 3\",\"id\":\"Q9P2X0\"}]", "uniprot_id": "[\"O60762\",\"O94777\",\"Q9P2X0\"]", "gene_symbol": "[\"DPM1\",\"DPM2\",\"DPM3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Maturation of protein M", "protein_name": "[{\"label\":\"Membrane protein\",\"id\":\"P59596\"}]", "uniprot_id": "[\"P59596\"]", "gene_symbol": "[\"M\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Serotonin receptors", "protein_name": "[{\"label\":\"5-hydroxytryptamine receptor 1A\",\"id\":\"P08908\"},{\"label\":\"5-hydroxytryptamine receptor 1B\",\"id\":\"P28222\"},{\"label\":\"5-hydroxytryptamine receptor 1D\",\"id\":\"P28221\"},{\"label\":\"5-hydroxytryptamine receptor 1E\",\"id\":\"P28566\"},{\"label\":\"5-hydroxytryptamine receptor 1F\",\"id\":\"P30939\"},{\"label\":\"5-hydroxytryptamine receptor 2A\",\"id\":\"P28223\"},{\"label\":\"5-hydroxytryptamine receptor 2B\",\"id\":\"P41595\"},{\"label\":\"5-hydroxytryptamine receptor 2C\",\"id\":\"P28335\"},{\"label\":\"5-hydroxytryptamine receptor 4\",\"id\":\"Q13639\"},{\"label\":\"5-hydroxytryptamine receptor 5A\",\"id\":\"P47898\"},{\"label\":\"5-hydroxytryptamine receptor 6\",\"id\":\"P50406\"},{\"label\":\"5-hydroxytryptamine receptor 7\",\"id\":\"P34969\"}]", "uniprot_id": "[\"P08908\",\"P28221\",\"P28222\",\"P28223\",\"P28335\",\"P28566\",\"P30939\",\"P34969\",\"P41595\",\"P47898\",\"P50406\",\"Q13639\"]", "gene_symbol": "[\"ADRB2RL1\",\"ADRBRL1\",\"HTR1A\",\"HTR1B\",\"HTR1C\",\"HTR1D\",\"HTR1DA\",\"HTR1DB\",\"HTR1E\",\"HTR1EL\",\"HTR1F\",\"HTR2\",\"HTR2A\",\"HTR2B\",\"HTR2C\",\"HTR4\",\"HTR5A\",\"HTR6\",\"HTR7\",\"HTRL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Class B/2 (Secretin family receptors)", "protein_name": "[{\"label\":\"Adhesion G protein-coupled receptor E1\",\"id\":\"Q14246\"},{\"label\":\"Adhesion G 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hedgehog protein\",\"id\":\"Q14623\"},{\"label\":\"Parathyroid hormone 2 receptor\",\"id\":\"P49190\"},{\"label\":\"Parathyroid hormone-related protein\",\"id\":\"P12272\"},{\"label\":\"Parathyroid hormone/parathyroid hormone-related peptide receptor\",\"id\":\"Q03431\"},{\"label\":\"Parathyroid hormone\",\"id\":\"P01270\"},{\"label\":\"Protein Wnt-10a\",\"id\":\"Q9GZT5\"},{\"label\":\"Protein Wnt-10b\",\"id\":\"O00744\"},{\"label\":\"Protein Wnt-11\",\"id\":\"O96014\"},{\"label\":\"Protein Wnt-16\",\"id\":\"Q9UBV4\"},{\"label\":\"Protein Wnt-2\",\"id\":\"P09544\"},{\"label\":\"Protein Wnt-2b\",\"id\":\"Q93097\"},{\"label\":\"Protein Wnt-3a\",\"id\":\"P56704\"},{\"label\":\"Protein Wnt-4\",\"id\":\"P56705\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Protein Wnt-6\",\"id\":\"Q9Y6F9\"},{\"label\":\"Protein Wnt-7a\",\"id\":\"O00755\"},{\"label\":\"Protein Wnt-7b\",\"id\":\"P56706\"},{\"label\":\"Protein Wnt-8a\",\"id\":\"Q9H1J5\"},{\"label\":\"Protein Wnt-8b\",\"id\":\"Q93098\"},{\"label\":\"Protein Wnt-9a\",\"id\":\"O14904\"},{\"label\":\"Protein Wnt-9b\",\"id\":\"O14905\"},{\"label\":\"Protein patched homolog 1\",\"id\":\"Q13635\"},{\"label\":\"Protein patched homolog 2\",\"id\":\"Q9Y6C5\"},{\"label\":\"Protein smoothened\",\"id\":\"Q99835\"},{\"label\":\"Proto-oncogene Wnt-1\",\"id\":\"P04628\"},{\"label\":\"Proto-oncogene Wnt-3\",\"id\":\"P56703\"},{\"label\":\"Sonic hedgehog protein\",\"id\":\"Q15465\"},{\"label\":\"Tuberoinfundibular peptide of 39 residues\",\"id\":\"Q96A98\"},{\"label\":\"Urocortin-2\",\"id\":\"Q96RP3\"},{\"label\":\"Urocortin-3\",\"id\":\"Q969E3\"},{\"label\":\"Urocortin\",\"id\":\"P55089\"}]", "uniprot_id": 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receptor\",\"id\":\"P00533\"},{\"label\":\"Epigen\",\"id\":\"Q6UW88\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"Paxillin\",\"id\":\"P49023\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphoprotein associated with glycosphingolipid-enriched microdomains 1\",\"id\":\"Q9NWQ8\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Protransforming growth factor alpha\",\"id\":\"P01135\"},{\"label\":\"Tyrosine-protein kinase CSK\",\"id\":\"P41240\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O14944\",\"P00533\",\"P01133\",\"P01135\",\"P12931\",\"P15514\",\"P27986\",\"P35070\",\"P41240\",\"P42336\",\"P49023\",\"Q06124\",\"Q13480\",\"Q6UW88\",\"Q99075\",\"Q9NWQ8\"]", "gene_symbol": "[\"AREG\",\"AREGB\",\"BTC\",\"CBP\",\"CSK\",\"DTR\",\"DTS\",\"EGF\",\"EGFR\",\"EPGN\",\"ERBB\",\"ERBB1\",\"EREG\",\"GAB1\",\"GRB1\",\"HBEGF\",\"HEGFL\",\"HER1\",\"PAG\",\"PAG1\",\"PIK3CA\",\"PIK3R1\",\"PTP2C\",\"PTPN11\",\"PXN\",\"SDGF\",\"SHPTP2\",\"SRC\",\"SRC1\",\"TGFA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MyD88 dependent cascade initiated on endosome", "protein_name": "[{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"Interleukin-1 receptor-associated kinase 4\",\"id\":\"Q9NWZ3\"},{\"label\":\"Interleukin-1 receptor-associated kinase-like 2\",\"id\":\"O43187\"},{\"label\":\"Myeloid differentiation primary response protein MyD88\",\"id\":\"Q99836\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Toll-like receptor 7\",\"id\":\"Q9NYK1\"},{\"label\":\"Toll-like receptor 9\",\"id\":\"Q9NR96\"}]", "uniprot_id": "[\"O43187\",\"P51617\",\"Q99836\",\"Q9NR96\",\"Q9NWZ3\",\"Q9NYK1\",\"Q9Y4K3\"]", "gene_symbol": "[\"IRAK\",\"IRAK1\",\"IRAK2\",\"IRAK4\",\"MYD88\",\"RNF85\",\"TLR7\",\"TLR9\",\"TRAF6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NTRK3 as a dependence receptor", "protein_name": "[{\"label\":\"Apoptosis regulator BAX\",\"id\":\"Q07812\"},{\"label\":\"NT-3 growth factor receptor\",\"id\":\"Q16288\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"}]", "uniprot_id": "[\"Q07812\",\"Q16288\",\"Q8WX92\"]", "gene_symbol": "[\"BAX\",\"BCL2L4\",\"COBRA1\",\"KIAA1182\",\"NELFB\",\"NTRK3\",\"TRKC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by RNF43 mutants", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase RNF43\",\"id\":\"Q68DV7\"},{\"label\":\"Frizzled-4\",\"id\":\"Q9ULV1\"},{\"label\":\"Frizzled-5\",\"id\":\"Q13467\"},{\"label\":\"Frizzled-6\",\"id\":\"O60353\"},{\"label\":\"Frizzled-8\",\"id\":\"Q9H461\"},{\"label\":\"Low-density lipoprotein receptor-related protein 5\",\"id\":\"O75197\"},{\"label\":\"Low-density lipoprotein receptor-related protein 6\",\"id\":\"O75581\"},{\"label\":\"Protein Wnt-3a\",\"id\":\"P56704\"}]", "uniprot_id": "[\"O60353\",\"O75197\",\"O75581\",\"P56704\",\"Q13467\",\"Q68DV7\",\"Q9H461\",\"Q9ULV1\"]", "gene_symbol": "[\"C2orf31\",\"FZD4\",\"FZD5\",\"FZD6\",\"FZD8\",\"LR3\",\"LRP5\",\"LRP6\",\"LRP7\",\"RNF43\",\"WNT3A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC6A5 causes hyperekplexia 3 (HKPX3)", "protein_name": "[{\"label\":\"Sodium- and chloride-dependent glycine transporter 2\",\"id\":\"Q9Y345\"}]", "uniprot_id": "[\"Q9Y345\"]", "gene_symbol": "[\"GLYT2\",\"NET1\",\"SLC6A5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Negative regulation of FGFR1 signaling", "protein_name": "[{\"label\":\"Anosmin-1\",\"id\":\"P23352\"},{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 22\",\"id\":\"Q9HCT0\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 3\",\"id\":\"P11487\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O15520\",\"P05230\",\"P08620\",\"P09038\",\"P0CG47\",\"P0CG48\",\"P10767\",\"P11487\",\"P22681\",\"P23352\",\"P27361\",\"P28482\",\"P31371\",\"P62979\",\"P62987\",\"Q06124\",\"Q8WU20\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", "gene_symbol": 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"[{\"label\":\"Kinesin-like protein KIF20A\",\"id\":\"O95235\"},{\"label\":\"Kinesin-like protein KIF23\",\"id\":\"Q02241\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"}]", "uniprot_id": "[\"O95235\",\"P53350\",\"Q02241\"]", "gene_symbol": "[\"KIF20A\",\"KIF23\",\"KNSL5\",\"MKLP1\",\"MKLP2\",\"PLK\",\"PLK1\",\"RAB6KIFL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin receptor SHC signaling", "protein_name": "[{\"label\":\"Cytokine receptor common subunit beta\",\"id\":\"P32927\"},{\"label\":\"Cytokine receptor common subunit gamma\",\"id\":\"P31785\"},{\"label\":\"GRB2-associated-binding protein 2\",\"id\":\"Q9UQC2\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor receptor subunit alpha\",\"id\":\"P15509\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor\",\"id\":\"P04141\"},{\"label\":\"Interleukin-2 receptor subunit alpha\",\"id\":\"P01589\"},{\"label\":\"Interleukin-2 receptor subunit beta\",\"id\":\"P14784\"},{\"label\":\"Interleukin-2\",\"id\":\"P60568\"},{\"label\":\"Interleukin-3 receptor subunit alpha\",\"id\":\"P26951\"},{\"label\":\"Interleukin-3\",\"id\":\"P08700\"},{\"label\":\"Interleukin-5 receptor subunit alpha\",\"id\":\"Q01344\"},{\"label\":\"Interleukin-5\",\"id\":\"P05113\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1\",\"id\":\"Q92835\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2\",\"id\":\"O15357\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform\",\"id\":\"O00329\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein kinase JAK3\",\"id\":\"P52333\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"}]", "uniprot_id": "[\"O00329\",\"O00459\",\"O15357\",\"O60674\",\"P01589\",\"P04141\",\"P05113\",\"P08700\",\"P14784\",\"P15509\",\"P23458\",\"P26951\",\"P27986\",\"P29350\",\"P29353\",\"P31785\",\"P32927\",\"P42336\",\"P42338\",\"P52333\",\"P60568\",\"Q01344\",\"Q07889\",\"Q92569\",\"Q92835\",\"Q9UQC2\"]", "gene_symbol": 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carboxyl-terminal hydrolase 7\",\"id\":\"Q93009\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"P0CG47\",\"P0CG48\",\"P29590\",\"P46934\",\"P60484\",\"P62979\",\"P62987\",\"P98170\",\"Q93009\"]", "gene_symbol": "[\"API3\",\"BIRC4\",\"HAUSP\",\"IAP3\",\"KIAA0093\",\"MMAC1\",\"MYL\",\"NEDD4\",\"NEDD4-1\",\"PML\",\"PP8675\",\"PTEN\",\"RNF71\",\"RPF1\",\"RPS27A\",\"TEP1\",\"TRIM19\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"USP7\",\"XIAP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ERBB2 Regulates Cell Motility", "protein_name": "[{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Protein MEMO1\",\"id\":\"Q9Y316\"},{\"label\":\"Protein diaphanous homolog 1\",\"id\":\"O60610\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"}]", "uniprot_id": "[\"O14511\",\"O14944\",\"O60610\",\"P00533\",\"P01133\",\"P04626\",\"P35070\",\"P56975\",\"P61586\",\"Q02297\",\"Q8WWG1\",\"Q99075\",\"Q9Y316\"]", "gene_symbol": 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collagenase\",\"id\":\"P03956\"},{\"label\":\"Kallikrein-2\",\"id\":\"P20151\"},{\"label\":\"Matrilysin\",\"id\":\"P09237\"},{\"label\":\"Matrix metalloproteinase-14\",\"id\":\"P50281\"},{\"label\":\"Matrix metalloproteinase-15\",\"id\":\"P51511\"},{\"label\":\"Matrix metalloproteinase-16\",\"id\":\"P51512\"},{\"label\":\"Matrix metalloproteinase-17\",\"id\":\"Q9ULZ9\"},{\"label\":\"Matrix metalloproteinase-24\",\"id\":\"Q9Y5R2\"},{\"label\":\"Matrix metalloproteinase-25\",\"id\":\"Q9NPA2\"},{\"label\":\"Matrix metalloproteinase-9\",\"id\":\"P14780\"},{\"label\":\"Metalloproteinase inhibitor 1\",\"id\":\"P01033\"},{\"label\":\"Metalloproteinase inhibitor 2\",\"id\":\"P16035\"},{\"label\":\"Neutrophil collagenase\",\"id\":\"P22894\"},{\"label\":\"Neutrophil elastase\",\"id\":\"P08246\"},{\"label\":\"Plasma kallikrein\",\"id\":\"P03952\"},{\"label\":\"Plasminogen\",\"id\":\"P00747\"},{\"label\":\"Serine protease 1\",\"id\":\"P07477\"},{\"label\":\"Stromelysin-1\",\"id\":\"P08254\"},{\"label\":\"Stromelysin-2\",\"id\":\"P09238\"},{\"label\":\"Stromelysin-3\",\"id\":\"P24347\"},{\"label\":\"Testican-3\",\"id\":\"Q9BQ16\"},{\"label\":\"Trypsin-2\",\"id\":\"P07478\"},{\"label\":\"Tryptase alpha/beta-1\",\"id\":\"Q15661\"}]", "uniprot_id": "[\"O60911\",\"P00747\",\"P01033\",\"P03952\",\"P03956\",\"P07477\",\"P07478\",\"P08246\",\"P08253\",\"P08254\",\"P08311\",\"P09237\",\"P09238\",\"P09958\",\"P14780\",\"P16035\",\"P17538\",\"P20151\",\"P22894\",\"P23946\",\"P24347\",\"P39060\",\"P43235\",\"P45452\",\"P50281\",\"P51511\",\"P51512\",\"Q15661\",\"Q6GPI1\",\"Q9BQ16\",\"Q9NPA2\",\"Q9ULZ9\",\"Q9Y5R2\"]", "gene_symbol": "[\"C8orf57\",\"CATL2\",\"CLG\",\"CLG1\",\"CLG4A\",\"CLG4B\",\"CLGI\",\"CMA1\",\"COL18A1\",\"CTRB\",\"CTRB1\",\"CTRB2\",\"CTSG\",\"CTSK\",\"CTSL2\",\"CTSO\",\"CTSO2\",\"CTSU\",\"CTSV\",\"CYH\",\"CYM\",\"ELA2\",\"ELANE\",\"FUR\",\"FURIN\",\"KLK2\",\"KLK3\",\"KLKB1\",\"MMP1\",\"MMP10\",\"MMP11\",\"MMP13\",\"MMP14\",\"MMP15\",\"MMP16\",\"MMP17\",\"MMP2\",\"MMP20\",\"MMP24\",\"MMP25\",\"MMP3\",\"MMP7\",\"MMP8\",\"MMP9\",\"MMPL1\",\"MMPX2\",\"MPSL1\",\"MT4MMP\",\"MT5MMP\",\"MT6MMP\",\"PACE\",\"PCSK3\",\"PLG\",\"PRSS1\",\"PRSS2\",\"PUMP1\",\"SPOCK3\",\"STMY1\",\"STMY2\",\"STMY3\",\"TICN3\",\"TIMP\",\"TIMP1\",\"TIMP2\",\"TPS1\",\"TPS2\",\"TPSAB1\",\"TPSB1\",\"TRP1\",\"TRY1\",\"TRY2\",\"TRYP1\",\"TRYP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcriptional Regulation by VENTX", "protein_name": "[{\"label\":\"Anaphase-promoting complex subunit 10\",\"id\":\"Q9UM13\"},{\"label\":\"Anaphase-promoting complex subunit 11\",\"id\":\"Q9NYG5\"},{\"label\":\"Anaphase-promoting complex subunit 15\",\"id\":\"P60006\"},{\"label\":\"Anaphase-promoting complex subunit 16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 5\",\"id\":\"Q9UJX4\"},{\"label\":\"Anaphase-promoting complex subunit 7\",\"id\":\"Q9UJX3\"},{\"label\":\"Anaphase-promoting complex subunit CDC26\",\"id\":\"Q8NHZ8\"},{\"label\":\"CCAAT/enhancer-binding protein beta\",\"id\":\"P17676\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Cell division cycle protein 16 homolog\",\"id\":\"Q13042\"},{\"label\":\"Cell division cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Cyclin-dependent kinase inhibitor 2A\",\"id\":\"P42771\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT1\",\"id\":\"Q9H9B1\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT2\",\"id\":\"Q96KQ7\"},{\"label\":\"Homeobox protein VENTX\",\"id\":\"O95231\"},{\"label\":\"Interleukin-6\",\"id\":\"P05231\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Macrophage colony-stimulating factor 1 receptor\",\"id\":\"P07333\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Transcription factor 7-like 2\",\"id\":\"Q9NQB0\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"}]", "uniprot_id": "[\"O00762\",\"O95231\",\"P04637\",\"P05231\",\"P07333\",\"P17676\",\"P19838\",\"P24385\",\"P30260\",\"P35222\",\"P42771\",\"P51668\",\"P51965\",\"P60006\",\"Q04206\",\"Q13042\",\"Q16763\",\"Q8NDV7\",\"Q8NHZ8\",\"Q96DE5\",\"Q96KQ7\",\"Q9H1A4\",\"Q9H9B1\",\"Q9H9G7\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9NQB0\",\"Q9NYG5\",\"Q9UJU2\",\"Q9UJX2\",\"Q9UJX3\",\"Q9UJX4\",\"Q9UJX5\",\"Q9UJX6\",\"Q9UL18\",\"Q9UM11\",\"Q9UM13\",\"Q9UPQ9\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Sialic acid metabolism", "protein_name": "[{\"label\":\"Alpha-2,8-sialyltransferase 8B\",\"id\":\"Q92186\"},{\"label\":\"Alpha-2,8-sialyltransferase 8E\",\"id\":\"O15466\"},{\"label\":\"Alpha-2,8-sialyltransferase 8F\",\"id\":\"P61647\"},{\"label\":\"Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase\",\"id\":\"Q9H4F1\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1\",\"id\":\"Q9NSC7\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2\",\"id\":\"Q9UJ37\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3\",\"id\":\"Q8NDV1\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5\",\"id\":\"Q9BVH7\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6\",\"id\":\"Q969X2\"},{\"label\":\"Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3\",\"id\":\"O43173\"},{\"label\":\"Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase\",\"id\":\"Q92185\"},{\"label\":\"Beta-galactosidase\",\"id\":\"P16278\"},{\"label\":\"Beta-galactoside alpha-2,6-sialyltransferase 1\",\"id\":\"P15907\"},{\"label\":\"Beta-galactoside alpha-2,6-sialyltransferase 2\",\"id\":\"Q96JF0\"},{\"label\":\"Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase\",\"id\":\"Q9Y223\"},{\"label\":\"CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase\",\"id\":\"Q11203\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1\",\"id\":\"Q11201\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2\",\"id\":\"Q16842\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4\",\"id\":\"Q11206\"},{\"label\":\"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase\",\"id\":\"Q92187\"},{\"label\":\"CMP-sialic acid transporter\",\"id\":\"P78382\"},{\"label\":\"Lactosylceramide alpha-2,3-sialyltransferase\",\"id\":\"Q9UNP4\"},{\"label\":\"Lysosomal protective protein\",\"id\":\"P10619\"},{\"label\":\"N-acetylneuraminate lyase\",\"id\":\"Q9BXD5\"},{\"label\":\"N-acylneuraminate cytidylyltransferase\",\"id\":\"Q8NFW8\"},{\"label\":\"N-acylneuraminate-9-phosphatase\",\"id\":\"Q8TBE9\"},{\"label\":\"Sialic acid synthase\",\"id\":\"Q9NR45\"},{\"label\":\"Sialidase-1\",\"id\":\"Q99519\"},{\"label\":\"Sialidase-2\",\"id\":\"Q9Y3R4\"},{\"label\":\"Sialidase-3\",\"id\":\"Q9UQ49\"},{\"label\":\"Sialidase-4\",\"id\":\"Q8WWR8\"},{\"label\":\"Sialin\",\"id\":\"Q9NRA2\"},{\"label\":\"Type 2 lactosamine alpha-2,3-sialyltransferase\",\"id\":\"Q9Y274\"}]", "uniprot_id": 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"[\"C1orf13\",\"C20orf147\",\"CGS23\",\"CMAS\",\"CTSA\",\"ELNR1\",\"GLB1\",\"GLCNE\",\"GNE\",\"HDHD4\",\"IBM2\",\"KIAA1877\",\"NANH\",\"NANP\",\"NANS\",\"NANTA3\",\"NEU1\",\"NEU2\",\"NEU3\",\"NEU4\",\"NPL\",\"PPGB\",\"PST\",\"PST1\",\"SAS\",\"SIAT1\",\"SIAT10\",\"SIAT2\",\"SIAT3C\",\"SIAT4\",\"SIAT4A\",\"SIAT4B\",\"SIAT4C\",\"SIAT6\",\"SIAT7A\",\"SIAT7B\",\"SIAT7C\",\"SIAT7D\",\"SIAT7E\",\"SIAT7F\",\"SIAT8\",\"SIAT8A\",\"SIAT8B\",\"SIAT8C\",\"SIAT8D\",\"SIAT8E\",\"SIAT8F\",\"SIAT9\",\"SIATL1\",\"SLC17A5\",\"SLC35A1\",\"ST3GAL1\",\"ST3GAL2\",\"ST3GAL3\",\"ST3GAL4\",\"ST3GAL5\",\"ST3GAL6\",\"ST6GAL1\",\"ST6GAL2\",\"ST6GALNAC1\",\"ST6GALNAC2\",\"ST6GALNAC3\",\"ST6GALNAC4\",\"ST6GALNAC5\",\"ST6GALNAC6\",\"ST8SIA1\",\"ST8SIA2\",\"ST8SIA3\",\"ST8SIA4\",\"ST8SIA5\",\"ST8SIA6\",\"STHM\",\"STX\",\"STZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by LRP5 mutants", "protein_name": "[{\"label\":\"Dickkopf-related protein 1\",\"id\":\"O94907\"},{\"label\":\"Dickkopf-related protein 2\",\"id\":\"Q9UBU2\"},{\"label\":\"Dickkopf-related protein 4\",\"id\":\"Q9UBT3\"},{\"label\":\"Kremen protein 1\",\"id\":\"Q96MU8\"},{\"label\":\"Kremen protein 2\",\"id\":\"Q8NCW0\"},{\"label\":\"Low-density lipoprotein receptor-related protein 5\",\"id\":\"O75197\"}]", "uniprot_id": "[\"O75197\",\"O94907\",\"Q8NCW0\",\"Q96MU8\",\"Q9UBT3\",\"Q9UBU2\"]", "gene_symbol": "[\"DKK1\",\"DKK2\",\"DKK4\",\"KREMEN\",\"KREMEN1\",\"KREMEN2\",\"KRM1\",\"KRM2\",\"LR3\",\"LRP5\",\"LRP7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NIK-->noncanonical NF-kB signaling", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"F-box/WD repeat-containing protein 11\",\"id\":\"Q9UKB1\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 14\",\"id\":\"Q99558\"},{\"label\":\"NEDD8-activating enzyme E1 catalytic subunit\",\"id\":\"Q8TBC4\"},{\"label\":\"NEDD8-conjugating enzyme Ubc12\",\"id\":\"P61081\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"Transcription factor RelB\",\"id\":\"Q01201\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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transcript 3 protein\",\"id\":\"P35638\"},{\"label\":\"Endoplasmic reticulum chaperone BiP\",\"id\":\"P11021\"},{\"label\":\"Endoplasmin\",\"id\":\"P14625\"},{\"label\":\"Nuclear transcription factor Y subunit alpha\",\"id\":\"P23511\"},{\"label\":\"Nuclear transcription factor Y subunit beta\",\"id\":\"P25208\"},{\"label\":\"Nuclear transcription factor Y subunit gamma\",\"id\":\"Q13952\"}]", "uniprot_id": "[\"P11021\",\"P14625\",\"P18848\",\"P18850\",\"P23511\",\"P25208\",\"P27797\",\"P35638\",\"Q13952\"]", "gene_symbol": "[\"ATF4\",\"ATF6\",\"CALR\",\"CHOP\",\"CHOP10\",\"CREB2\",\"CRTC\",\"DDIT3\",\"GADD153\",\"GRP78\",\"GRP94\",\"HAP3\",\"HSP90B1\",\"HSPA5\",\"HSPC4\",\"NFYA\",\"NFYB\",\"NFYC\",\"TRA1\",\"TXREB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "KW2449-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX1 regulates estrogen receptor mediated transcription", "protein_name": "[{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"BTB/POZ domain-containing protein KCTD6\",\"id\":\"Q8NC69\"},{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"Estrogen receptor\",\"id\":\"P03372\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 1, mitochondrial\",\"id\":\"Q9HCL2\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"}]", "uniprot_id": "[\"O15169\",\"P03372\",\"Q01196\",\"Q13951\",\"Q8NC69\",\"Q9HCL2\"]", "gene_symbol": "[\"AML1\",\"AXIN\",\"AXIN1\",\"CBFA2\",\"CBFB\",\"ESR\",\"ESR1\",\"GPAM\",\"GPAT1\",\"KCTD6\",\"KIAA1560\",\"NR3A1\",\"RUNX1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Erythropoietin activates Phospholipase C gamma (PLCG)", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2\",\"id\":\"P16885\"},{\"label\":\"Erythropoietin receptor\",\"id\":\"P19235\"},{\"label\":\"Erythropoietin\",\"id\":\"P01588\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"}]", "uniprot_id": "[\"O60674\",\"P01588\",\"P07948\",\"P16885\",\"P19174\",\"P19235\",\"Q9Y4H2\"]", "gene_symbol": "[\"EPO\",\"EPOR\",\"IRS2\",\"JAK2\",\"JTK8\",\"LYN\",\"PLC1\",\"PLCG1\",\"PLCG2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective VWF cleavage by ADAMTS13 variant", "protein_name": "[{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 13\",\"id\":\"Q76LX8\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"P04275\",\"Q76LX8\"]", "gene_symbol": "[\"ADAMTS13\",\"C9orf8\",\"F8VWF\",\"VWF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "LXRs regulate gene expression linked to lipogenesis", "protein_name": "[{\"label\":\"Angiopoietin-related protein 3\",\"id\":\"Q9Y5C1\"},{\"label\":\"Fatty acid synthase\",\"id\":\"P49327\"},{\"label\":\"Nuclear receptor-interacting protein 1\",\"id\":\"P48552\"},{\"label\":\"Oxysterols receptor LXR-alpha\",\"id\":\"Q13133\"},{\"label\":\"Oxysterols receptor LXR-beta\",\"id\":\"P55055\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Retinoic acid receptor RXR-beta\",\"id\":\"P28702\"},{\"label\":\"Stearoyl-CoA desaturase\",\"id\":\"O00767\"}]", "uniprot_id": "[\"O00767\",\"P19793\",\"P28702\",\"P48552\",\"P49327\",\"P55055\",\"Q13133\",\"Q9Y5C1\"]", "gene_symbol": "[\"ANGPT5\",\"ANGPTL3\",\"FADS5\",\"FAS\",\"FASN\",\"LXRA\",\"LXRB\",\"NER\",\"NR1H2\",\"NR1H3\",\"NR2B1\",\"NR2B2\",\"NRIP1\",\"RXRA\",\"RXRB\",\"SCD\",\"SCD1\",\"SCDOS\",\"UNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Suppression of autophagy", "protein_name": "[{\"label\":\"Dual specificity protein phosphatase 16\",\"id\":\"Q9BY84\"},{\"label\":\"N-acetyltransferase Eis\",\"id\":\"P9WFK7\"},{\"label\":\"Phosphatidylinositol-3-phosphatase\",\"id\":\"O53361\"},{\"label\":\"Ras-related protein Rab-7a\",\"id\":\"P51149\"}]", "uniprot_id": "[\"O53361\",\"P51149\",\"P9WFK7\",\"Q9BY84\"]", "gene_symbol": "[\"DUSP16\",\"KIAA1700\",\"MKP7\",\"RAB7\",\"RAB7A\",\"eis\",\"sapM\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Disinhibition of SNARE formation", "protein_name": "[{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Protein kinase C beta type\",\"id\":\"P05771\"},{\"label\":\"Protein kinase C gamma type\",\"id\":\"P05129\"},{\"label\":\"Syntaxin-4\",\"id\":\"Q12846\"},{\"label\":\"Syntaxin-binding protein 3\",\"id\":\"O00186\"}]", "uniprot_id": "[\"O00186\",\"P05129\",\"P05771\",\"P17252\",\"Q12846\"]", "gene_symbol": "[\"PKCA\",\"PKCB\",\"PKCG\",\"PRKACA\",\"PRKCA\",\"PRKCB\",\"PRKCB1\",\"PRKCG\",\"STX4\",\"STX4A\",\"STXBP3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": 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subunit\",\"id\":\"P10644\"},{\"label\":\"cAMP-dependent protein kinase type I-beta regulatory subunit\",\"id\":\"P31321\"},{\"label\":\"cAMP-dependent protein kinase type II-alpha regulatory subunit\",\"id\":\"P13861\"},{\"label\":\"cAMP-dependent protein kinase type II-beta regulatory subunit\",\"id\":\"P31323\"}]", "uniprot_id": "[\"O43306\",\"O60266\",\"O60503\",\"O95622\",\"P0DP23\",\"P10644\",\"P13861\",\"P17612\",\"P22612\",\"P22694\",\"P31321\",\"P31323\",\"P40145\",\"P51828\",\"Q08462\",\"Q08828\",\"Q8NFM4\",\"Q8NFP9\"]", "gene_symbol": "[\"ADCY1\",\"ADCY2\",\"ADCY3\",\"ADCY4\",\"ADCY5\",\"ADCY6\",\"ADCY7\",\"ADCY8\",\"ADCY9\",\"BCL8B\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"KIAA0037\",\"KIAA0422\",\"KIAA0511\",\"KIAA0520\",\"KIAA1060\",\"KIAA1544\",\"LYST2\",\"NBEA\",\"PKACA\",\"PKR1\",\"PKR2\",\"PRKACA\",\"PRKACB\",\"PRKACG\",\"PRKAR1\",\"PRKAR1A\",\"PRKAR1B\",\"PRKAR2\",\"PRKAR2A\",\"PRKAR2B\",\"TSE1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Adenylate cyclase activating pathway", "protein_name": "[{\"label\":\"Adenylate cyclase type 1\",\"id\":\"Q08828\"},{\"label\":\"Adenylate cyclase type 2\",\"id\":\"Q08462\"},{\"label\":\"Adenylate cyclase type 3\",\"id\":\"O60266\"},{\"label\":\"Adenylate cyclase type 4\",\"id\":\"Q8NFM4\"},{\"label\":\"Adenylate cyclase type 5\",\"id\":\"O95622\"},{\"label\":\"Adenylate cyclase type 6\",\"id\":\"O43306\"},{\"label\":\"Adenylate cyclase type 7\",\"id\":\"P51828\"},{\"label\":\"Adenylate cyclase type 8\",\"id\":\"P40145\"},{\"label\":\"Adenylate cyclase type 9\",\"id\":\"O60503\"},{\"label\":\"Guanine nucleotide-binding protein G(olf) subunit alpha\",\"id\":\"P38405\"}]", "uniprot_id": "[\"O43306\",\"O60266\",\"O60503\",\"O95622\",\"P38405\",\"P40145\",\"P51828\",\"Q08462\",\"Q08828\",\"Q8NFM4\"]", "gene_symbol": "[\"ADCY1\",\"ADCY2\",\"ADCY3\",\"ADCY4\",\"ADCY5\",\"ADCY6\",\"ADCY7\",\"ADCY8\",\"ADCY9\",\"GNAL\",\"KIAA0037\",\"KIAA0422\",\"KIAA0511\",\"KIAA0520\",\"KIAA1060\"]", "gtc_id": "[\"\"]" }, { 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channel 6\",\"id\":\"Q9Y210\"},{\"label\":\"Short transient receptor potential channel 7\",\"id\":\"Q9HCX4\"}]", "uniprot_id": "[\"O95631\",\"P19174\",\"P43146\",\"P48995\",\"Q00169\",\"Q13507\",\"Q9HCX4\",\"Q9UBN4\",\"Q9UL62\",\"Q9Y210\"]", "gene_symbol": "[\"DCC\",\"IGDCC1\",\"NTN1\",\"NTN1L\",\"PITPN\",\"PITPNA\",\"PLC1\",\"PLCG1\",\"TRP1\",\"TRP3\",\"TRP5\",\"TRP6\",\"TRP7\",\"TRPC1\",\"TRPC3\",\"TRPC4\",\"TRPC5\",\"TRPC6\",\"TRPC7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by PDGF", "protein_name": "[{\"label\":\"Collagen alpha-1(IV) chain\",\"id\":\"P02462\"},{\"label\":\"Collagen alpha-1(IX) chain\",\"id\":\"P20849\"},{\"label\":\"Collagen alpha-1(VI) chain\",\"id\":\"P12109\"},{\"label\":\"Collagen alpha-2(IV) chain\",\"id\":\"P08572\"},{\"label\":\"Collagen alpha-2(IX) chain\",\"id\":\"Q14055\"},{\"label\":\"Collagen alpha-2(VI) chain\",\"id\":\"P12110\"},{\"label\":\"Collagen alpha-3(IV) chain\",\"id\":\"Q01955\"},{\"label\":\"Collagen alpha-3(IX) chain\",\"id\":\"Q14050\"},{\"label\":\"Collagen alpha-3(VI) chain\",\"id\":\"P12111\"},{\"label\":\"Collagen alpha-4(IV) chain\",\"id\":\"P53420\"},{\"label\":\"Collagen alpha-5(IV) chain\",\"id\":\"P29400\"},{\"label\":\"Collagen alpha-5(VI) chain\",\"id\":\"A8TX70\"},{\"label\":\"Collagen alpha-6(VI) chain\",\"id\":\"A6NMZ7\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Osteopontin\",\"id\":\"P10451\"},{\"label\":\"Plasminogen\",\"id\":\"P00747\"},{\"label\":\"Platelet-derived growth factor D\",\"id\":\"Q9GZP0\"},{\"label\":\"Platelet-derived growth factor receptor alpha\",\"id\":\"P16234\"},{\"label\":\"Platelet-derived growth factor receptor beta\",\"id\":\"P09619\"},{\"label\":\"Platelet-derived growth factor subunit B\",\"id\":\"P01127\"},{\"label\":\"Thrombospondin-1\",\"id\":\"P07996\"},{\"label\":\"Thrombospondin-2\",\"id\":\"P35442\"},{\"label\":\"Thrombospondin-3\",\"id\":\"P49746\"},{\"label\":\"Thrombospondin-4\",\"id\":\"P35443\"},{\"label\":\"Tissue-type plasminogen activator\",\"id\":\"P00750\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 12\",\"id\":\"Q05209\"}]", "uniprot_id": "[\"A6NMZ7\",\"A8TX70\",\"P00747\",\"P00750\",\"P01127\",\"P02462\",\"P07996\",\"P08572\",\"P09619\",\"P09958\",\"P10451\",\"P12109\",\"P12110\",\"P12111\",\"P16234\",\"P20849\",\"P29400\",\"P35442\",\"P35443\",\"P49746\",\"P53420\",\"Q01955\",\"Q05209\",\"Q14050\",\"Q14055\",\"Q9GZP0\"]", "gene_symbol": "[\"BNSP\",\"COL29A1\",\"COL4A1\",\"COL4A2\",\"COL4A3\",\"COL4A4\",\"COL4A5\",\"COL6A1\",\"COL6A2\",\"COL6A3\",\"COL6A5\",\"COL6A6\",\"COL9A1\",\"COL9A2\",\"COL9A3\",\"FUR\",\"FURIN\",\"IEGF\",\"OPN\",\"PACE\",\"PCSK3\",\"PDGF2\",\"PDGFB\",\"PDGFD\",\"PDGFR\",\"PDGFR1\",\"PDGFR2\",\"PDGFRA\",\"PDGFRB\",\"PLAT\",\"PLG\",\"PTPN12\",\"RHEPDGFRA\",\"SCDGFB\",\"SIS\",\"SPP1\",\"THBS1\",\"THBS2\",\"THBS3\",\"THBS4\",\"TSP\",\"TSP1\",\"TSP2\",\"TSP3\",\"TSP4\",\"VWA4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MET activates PI3K/AKT signaling", 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F\",\"id\":\"Q13790\"},{\"label\":\"Apolipoprotein(a)\",\"id\":\"P08519\"},{\"label\":\"Cholesteryl ester transfer protein\",\"id\":\"P11597\"},{\"label\":\"Microsomal triglyceride transfer protein large subunit\",\"id\":\"P55157\"},{\"label\":\"Protein disulfide-isomerase\",\"id\":\"P07237\"}]", "uniprot_id": "[\"P04114\",\"P07237\",\"P08519\",\"P11597\",\"P55157\",\"Q13790\"]", "gene_symbol": "[\"APOB\",\"APOF\",\"CETP\",\"ERBA2L\",\"LPA\",\"MTP\",\"MTTP\",\"P4HB\",\"PDI\",\"PDIA1\",\"PO4DB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "GRB2 events in EGFR signaling", "protein_name": "[{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Epigen\",\"id\":\"Q6UW88\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Pro-epidermal growth 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protein\",\"id\":\"P59637\"},{\"label\":\"Protein PALS1\",\"id\":\"Q8N3R9\"}]", "uniprot_id": "[\"P59637\",\"Q8N3R9\"]", "gene_symbol": "[\"E\",\"MPP5\",\"PALS1\",\"sM\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activated NTRK2 signals through CDK5", "protein_name": "[{\"label\":\"BDNF/NT-3 growth factors receptor\",\"id\":\"Q16620\"},{\"label\":\"Brain-derived neurotrophic factor\",\"id\":\"P23560\"},{\"label\":\"Cyclin-dependent kinase 5 activator 1\",\"id\":\"Q15078\"},{\"label\":\"Cyclin-dependent kinase 5\",\"id\":\"Q00535\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM1\",\"id\":\"Q13009\"}]", "uniprot_id": "[\"P23560\",\"P63000\",\"Q00535\",\"Q13009\",\"Q15078\",\"Q16620\"]", "gene_symbol": "[\"BDNF\",\"CDK5\",\"CDK5R\",\"CDK5R1\",\"CDKN5\",\"NCK5A\",\"NTRK2\",\"PSSALRE\",\"RAC1\",\"TC25\",\"TIAM1\",\"TRKB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcriptional regulation by 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"gtc_id": "[\"\"]" }, { "pathway_label": "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "protein_name": "[{\"label\":\"Baculoviral IAP repeat-containing protein 2\",\"id\":\"Q13490\"},{\"label\":\"Baculoviral IAP repeat-containing protein 3\",\"id\":\"Q13489\"},{\"label\":\"CD40 ligand\",\"id\":\"P29965\"},{\"label\":\"Lymphotoxin-alpha\",\"id\":\"P01374\"},{\"label\":\"Lymphotoxin-beta\",\"id\":\"Q06643\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 14\",\"id\":\"Q99558\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"TNF receptor-associated factor 3\",\"id\":\"Q13114\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 11\",\"id\":\"O14788\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 12\",\"id\":\"O43508\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 13B\",\"id\":\"Q9Y275\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 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4,5-bisphosphate phosphodiesterase beta-4\",\"id\":\"Q15147\"},{\"label\":\"5-hydroxytryptamine receptor 2A\",\"id\":\"P28223\"},{\"label\":\"5-hydroxytryptamine receptor 2B\",\"id\":\"P41595\"},{\"label\":\"5-hydroxytryptamine receptor 2C\",\"id\":\"P28335\"},{\"label\":\"Alpha-1A adrenergic receptor\",\"id\":\"P35348\"},{\"label\":\"Alpha-1B adrenergic receptor\",\"id\":\"P35368\"},{\"label\":\"Alpha-1D adrenergic receptor\",\"id\":\"P25100\"},{\"label\":\"Amyloid-beta precursor protein\",\"id\":\"P05067\"},{\"label\":\"Angiotensinogen\",\"id\":\"P01019\"},{\"label\":\"Annexin A1\",\"id\":\"P04083\"},{\"label\":\"B1 bradykinin receptor\",\"id\":\"P46663\"},{\"label\":\"B2 bradykinin receptor\",\"id\":\"P30411\"},{\"label\":\"Beta-adrenergic receptor kinase 1\",\"id\":\"P25098\"},{\"label\":\"Bombesin receptor subtype-3\",\"id\":\"P32247\"},{\"label\":\"Chemokine XC receptor 1\",\"id\":\"P46094\"},{\"label\":\"Cholecystokinin receptor type A\",\"id\":\"P32238\"},{\"label\":\"Cholecystokinin\",\"id\":\"P06307\"},{\"label\":\"Cysteinyl leukotriene receptor 1\",\"id\":\"Q9Y271\"},{\"label\":\"Cysteinyl leukotriene receptor 2\",\"id\":\"Q9NS75\"},{\"label\":\"Cytokine SCM-1 beta\",\"id\":\"Q9UBD3\"},{\"label\":\"Endothelin receptor type B\",\"id\":\"P24530\"},{\"label\":\"Endothelin-1 receptor\",\"id\":\"P25101\"},{\"label\":\"Endothelin-1\",\"id\":\"P05305\"},{\"label\":\"Endothelin-2\",\"id\":\"P20800\"},{\"label\":\"Endothelin-3\",\"id\":\"P14138\"},{\"label\":\"Extracellular calcium-sensing receptor\",\"id\":\"P41180\"},{\"label\":\"Free fatty acid receptor 1\",\"id\":\"O14842\"},{\"label\":\"Free fatty acid receptor 2\",\"id\":\"O15552\"},{\"label\":\"Free fatty acid receptor 3\",\"id\":\"O14843\"},{\"label\":\"Free fatty acid receptor 4\",\"id\":\"Q5NUL3\"},{\"label\":\"G protein-coupled receptor kinase 5\",\"id\":\"P34947\"},{\"label\":\"G-protein coupled receptor 143\",\"id\":\"P51810\"},{\"label\":\"G-protein coupled receptor 39\",\"id\":\"O43194\"},{\"label\":\"G-protein coupled receptor 4\",\"id\":\"P46093\"},{\"label\":\"G-protein coupled receptor family C group 6 member A\",\"id\":\"Q5T6X5\"},{\"label\":\"Gastrin-releasing peptide receptor\",\"id\":\"P30550\"},{\"label\":\"Gastrin-releasing peptide\",\"id\":\"P07492\"},{\"label\":\"Gastrin/cholecystokinin type B receptor\",\"id\":\"P32239\"},{\"label\":\"Gastrin\",\"id\":\"P01350\"},{\"label\":\"Glucagon receptor\",\"id\":\"P47871\"},{\"label\":\"Gonadotropin-releasing hormone receptor\",\"id\":\"P30968\"},{\"label\":\"Growth hormone secretagogue receptor type 1\",\"id\":\"Q92847\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein 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"Interleukin-36 pathway", "protein_name": "[{\"label\":\"Interleukin-1 family member 10\",\"id\":\"Q8WWZ1\"},{\"label\":\"Interleukin-1 receptor-like 2\",\"id\":\"Q9HB29\"},{\"label\":\"Interleukin-36 alpha\",\"id\":\"Q9UHA7\"},{\"label\":\"Interleukin-36 beta\",\"id\":\"Q9NZH7\"},{\"label\":\"Interleukin-36 gamma\",\"id\":\"Q9NZH8\"},{\"label\":\"Interleukin-36 receptor antagonist protein\",\"id\":\"Q9UBH0\"}]", "uniprot_id": "[\"Q8WWZ1\",\"Q9HB29\",\"Q9NZH7\",\"Q9NZH8\",\"Q9UBH0\",\"Q9UHA7\"]", "gene_symbol": "[\"FIL1D\",\"FIL1E\",\"FIL1T\",\"IL1E\",\"IL1F10\",\"IL1F5\",\"IL1F6\",\"IL1F8\",\"IL1F9\",\"IL1H1\",\"IL1H2\",\"IL1HY1\",\"IL1HY2\",\"IL1L1\",\"IL1RL2\",\"IL1RP2\",\"IL1RP3\",\"IL1RRP2\",\"IL36A\",\"IL36B\",\"IL36G\",\"IL36RN\",\"IL38\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PI-3K cascade:FGFR4", "protein_name": "[{\"label\":\"Beta-klotho\",\"id\":\"Q86Z14\"},{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 19\",\"id\":\"O95750\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 4\",\"id\":\"P22455\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O43320\",\"O76093\",\"O95750\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P22455\",\"P27986\",\"P31371\",\"P42336\",\"Q06124\",\"Q13480\",\"Q86Z14\",\"Q8WU20\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF16\",\"FGF18\",\"FGF19\",\"FGF2\",\"FGF20\",\"FGF23\",\"FGF4\",\"FGF6\",\"FGF9\",\"FGFA\",\"FGFB\",\"FGFR4\",\"FRS2\",\"GAB1\",\"GRB1\",\"HST\",\"HST2\",\"HSTF1\",\"HSTF2\",\"HYPF\",\"JTK2\",\"KLB\",\"KS3\",\"PIK3CA\",\"PIK3R1\",\"PTP2C\",\"PTPN11\",\"SHPTP2\",\"TKF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective F8 accelerates dissociation of the A2 domain", "protein_name": "[{\"label\":\"Coagulation factor VIII\",\"id\":\"P00451\"}]", "uniprot_id": "[\"P00451\"]", "gene_symbol": "[\"F8\",\"F8C\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CTNNB1 S45 mutants aren't phosphorylated", "protein_name": "[{\"label\":\"APC membrane recruitment protein 1\",\"id\":\"Q5JTC6\"},{\"label\":\"Adenomatous polyposis coli protein\",\"id\":\"P25054\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Casein kinase I isoform alpha\",\"id\":\"P48729\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O15169\",\"P25054\",\"P30153\",\"P30154\",\"P35222\",\"P48729\",\"P49841\",\"P62714\",\"P67775\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\"]", "gene_symbol": "[\"AMER1\",\"APC\",\"AXIN\",\"AXIN1\",\"CSNK1A1\",\"CTNNB\",\"CTNNB1\",\"DP2.5\",\"FAM123B\",\"GSK3B\",\"KIAA0044\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"WTX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "AKT phosphorylates targets in the cytosol", "protein_name": "[{\"label\":\"Bcl2-associated agonist of cell death\",\"id\":\"Q92934\"},{\"label\":\"Caspase-9\",\"id\":\"P55211\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"E3 ubiquitin-protein ligase Mdm2\",\"id\":\"Q00987\"},{\"label\":\"E3 ubiquitin-protein ligase makorin-1\",\"id\":\"Q9UHC7\"},{\"label\":\"Glycogen synthase kinase-3 alpha\",\"id\":\"P49840\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Proline-rich AKT1 substrate 1\",\"id\":\"Q96B36\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Tuberin\",\"id\":\"P49815\"}]", "uniprot_id": "[\"O15111\",\"P31749\",\"P31751\",\"P38936\",\"P46527\",\"P49815\",\"P49840\",\"P49841\",\"P55211\",\"Q00987\",\"Q92934\",\"Q96B36\",\"Q9UHC7\",\"Q9Y243\"]", "gene_symbol": 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succinyl-coenzyme A thioesterase\",\"id\":\"Q8N9L9\"}]", "uniprot_id": "[\"O14734\",\"O14975\",\"P09110\",\"P33897\",\"P51659\",\"Q08426\",\"Q8N9L9\",\"Q9NUI1\"]", "gene_symbol": "[\"ABCD1\",\"ACAA\",\"ACAA1\",\"ACOT4\",\"ACOT8\",\"ACSVL1\",\"ACTEIII\",\"ALD\",\"DECR2\",\"ECHD\",\"EDH17B4\",\"EHHADH\",\"FACVL1\",\"FATP2\",\"HSD17B4\",\"PDCR\",\"PTE1\",\"PTE2B\",\"PTEIB\",\"PTHIO\",\"SDR17C1\",\"SDR8C1\",\"SLC27A2\",\"VLACS\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NEIL3-mediated resolution of ICLs", "protein_name": "[{\"label\":\"Endonuclease 8-like 3\",\"id\":\"Q8TAT5\"}]", "uniprot_id": "[\"Q8TAT5\"]", "gene_symbol": "[\"NEIL3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of Glucokinase by Glucokinase Regulatory Protein", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Glucokinase regulatory protein\",\"id\":\"Q14397\"},{\"label\":\"Hexokinase-4\",\"id\":\"P35557\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": 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1\",\"id\":\"Q05397\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 1\",\"id\":\"Q05586\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Intersectin-1\",\"id\":\"Q15811\"},{\"label\":\"Kalirin\",\"id\":\"O60229\"},{\"label\":\"LIM domain kinase 1\",\"id\":\"P53667\"},{\"label\":\"LIM domain kinase 2\",\"id\":\"P53671\"},{\"label\":\"Ras GTPase-activating protein 1\",\"id\":\"P20936\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Rho guanine nucleotide exchange factor 28\",\"id\":\"Q8N1W1\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM1\",\"id\":\"Q13009\"},{\"label\":\"Rho-associated protein kinase 1\",\"id\":\"Q13464\"},{\"label\":\"Rho-associated protein kinase 2\",\"id\":\"O75116\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase Yes\",\"id\":\"P07947\"}]", "uniprot_id": "[\"O00401\",\"O15143\",\"O15144\",\"O15145\",\"O15511\",\"O60229\",\"O75116\",\"P01112\",\"P06241\",\"P07947\",\"P07948\",\"P20936\",\"P23528\",\"P34741\",\"P53667\",\"P53671\",\"P59998\",\"P60709\",\"P60953\",\"P61158\",\"P61160\",\"P61586\",\"P63000\",\"P63261\",\"Q05397\",\"Q05586\",\"Q13009\",\"Q13153\",\"Q13224\",\"Q13464\",\"Q15811\",\"Q8N1W1\",\"Q92747\"]", "gene_symbol": 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domain-containing protein 17B\",\"id\":\"Q5VST6\"},{\"label\":\"Alpha/beta hydrolase domain-containing protein 17C\",\"id\":\"Q6PCB6\"},{\"label\":\"Bcl-2-like protein 1\",\"id\":\"Q07817\"},{\"label\":\"CAAX prenyl protease 2\",\"id\":\"Q9Y256\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase KRas\",\"id\":\"P01116\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Golgin subfamily A member 7\",\"id\":\"Q7Z5G4\"},{\"label\":\"Palmitoyltransferase ZDHHC9\",\"id\":\"Q9Y397\"},{\"label\":\"Protein farnesyltransferase subunit beta\",\"id\":\"P49356\"},{\"label\":\"Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha\",\"id\":\"P49354\"},{\"label\":\"Protein kinase C theta type\",\"id\":\"Q04759\"},{\"label\":\"Protein-S-isoprenylcysteine O-methyltransferase\",\"id\":\"O60725\"},{\"label\":\"Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta\",\"id\":\"O43924\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 17\",\"id\":\"Q6R6M4\"},{\"label\":\"cGMP-dependent protein kinase 2\",\"id\":\"Q13237\"}]", "uniprot_id": "[\"O43924\",\"O60725\",\"O75608\",\"P01111\",\"P01112\",\"P01116\",\"P0DP23\",\"P36404\",\"P49354\",\"P49356\",\"Q04759\",\"Q07817\",\"Q13237\",\"Q5VST6\",\"Q6PCB6\",\"Q6R6M4\",\"Q7Z5G4\",\"Q96GS6\",\"Q9Y256\",\"Q9Y397\"]", "gene_symbol": 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"protein_name": "[{\"label\":\"D-2-hydroxyglutarate dehydrogenase, mitochondrial\",\"id\":\"Q8N465\"},{\"label\":\"Hydroxyacid-oxoacid transhydrogenase, mitochondrial\",\"id\":\"Q8IWW8\"},{\"label\":\"L-2-hydroxyglutarate dehydrogenase, mitochondrial\",\"id\":\"Q9H9P8\"}]", "uniprot_id": "[\"Q8IWW8\",\"Q8N465\",\"Q9H9P8\"]", "gene_symbol": "[\"ADHFE1\",\"C14orf160\",\"D2HGD\",\"D2HGDH\",\"L2HGDH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Drug-mediated inhibition of ERBB2 signaling", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P04626\",\"P07900\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "EPH-Ephrin signaling", "protein_name": "[{\"label\":\"Ephrin type-A receptor 10\",\"id\":\"Q5JZY3\"},{\"label\":\"Ephrin type-A receptor 1\",\"id\":\"P21709\"},{\"label\":\"Ephrin type-A receptor 2\",\"id\":\"P29317\"},{\"label\":\"Ephrin type-A receptor 3\",\"id\":\"P29320\"},{\"label\":\"Ephrin type-A receptor 4\",\"id\":\"P54764\"},{\"label\":\"Ephrin type-A receptor 5\",\"id\":\"P54756\"},{\"label\":\"Ephrin type-A receptor 6\",\"id\":\"Q9UF33\"},{\"label\":\"Ephrin type-A receptor 7\",\"id\":\"Q15375\"},{\"label\":\"Ephrin type-A receptor 8\",\"id\":\"P29322\"},{\"label\":\"Ephrin type-B receptor 1\",\"id\":\"P54762\"},{\"label\":\"Ephrin type-B receptor 2\",\"id\":\"P29323\"},{\"label\":\"Ephrin type-B receptor 3\",\"id\":\"P54753\"},{\"label\":\"Ephrin type-B receptor 4\",\"id\":\"P54760\"},{\"label\":\"Ephrin type-B receptor 6\",\"id\":\"O15197\"},{\"label\":\"Ephrin-A1\",\"id\":\"P20827\"},{\"label\":\"Ephrin-A2\",\"id\":\"O43921\"},{\"label\":\"Ephrin-A3\",\"id\":\"P52797\"},{\"label\":\"Ephrin-A4\",\"id\":\"P52798\"},{\"label\":\"Ephrin-A5\",\"id\":\"P52803\"},{\"label\":\"Ephrin-B1\",\"id\":\"P98172\"},{\"label\":\"Ephrin-B2\",\"id\":\"P52799\"},{\"label\":\"Ephrin-B3\",\"id\":\"Q15768\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase Yes\",\"id\":\"P07947\"}]", "uniprot_id": "[\"O15197\",\"O43921\",\"P06241\",\"P07947\",\"P07948\",\"P20827\",\"P21709\",\"P29317\",\"P29320\",\"P29322\",\"P29323\",\"P52797\",\"P52798\",\"P52799\",\"P52803\",\"P54753\",\"P54756\",\"P54760\",\"P54762\",\"P54764\",\"P98172\",\"Q15375\",\"Q15768\",\"Q5JZY3\",\"Q9UF33\"]", "gene_symbol": 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mitochondrial\",\"id\":\"P56385\"},{\"label\":\"ATP synthase subunit epsilon, mitochondrial\",\"id\":\"P56381\"},{\"label\":\"ATP synthase subunit f, mitochondrial\",\"id\":\"P56134\"},{\"label\":\"ATP synthase subunit g, mitochondrial\",\"id\":\"O75964\"},{\"label\":\"ATP synthase subunit gamma, mitochondrial\",\"id\":\"P36542\"},{\"label\":\"ATP synthase subunit s, mitochondrial\",\"id\":\"Q99766\"},{\"label\":\"ATP synthase-coupling factor 6, mitochondrial\",\"id\":\"P18859\"}]", "uniprot_id": "[\"O75947\",\"O75964\",\"P00846\",\"P03928\",\"P05496\",\"P06576\",\"P18859\",\"P24539\",\"P25705\",\"P30049\",\"P36542\",\"P48047\",\"P48201\",\"P56134\",\"P56378\",\"P56381\",\"P56385\",\"Q06055\",\"Q96IX5\",\"Q99766\"]", "gene_symbol": 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RAE1\",\"id\":\"P78406\"},{\"label\":\"von Hippel-Lindau disease tumor suppressor\",\"id\":\"P40337\"}]", "uniprot_id": "[\"A8CG34\",\"O15504\",\"O75694\",\"O75925\",\"P12270\",\"P14373\",\"P29590\",\"P35658\",\"P37198\",\"P40337\",\"P49790\",\"P49792\",\"P55735\",\"P57740\",\"P63165\",\"P63279\",\"P78406\",\"Q00987\",\"Q12769\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8N1F7\",\"Q8N2W9\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q96HA1\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9NRG9\",\"Q9UKX7\"]", "gene_symbol": 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plakoglobin\",\"id\":\"P14923\"},{\"label\":\"Lamina-associated polypeptide 2, isoforms beta/gamma\",\"id\":\"P42167\"},{\"label\":\"MAGUK p55 subfamily member 7\",\"id\":\"Q5T2T1\"},{\"label\":\"Metalloreductase STEAP3\",\"id\":\"Q658P3\"},{\"label\":\"NEDD4-like E3 ubiquitin-protein ligase WWP2\",\"id\":\"O00308\"},{\"label\":\"Neutral amino acid transporter B(0)\",\"id\":\"Q15758\"},{\"label\":\"Oligophrenin-1\",\"id\":\"O60890\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Protein NipSnap homolog 2\",\"id\":\"O75323\"},{\"label\":\"Protein diaphanous homolog 3\",\"id\":\"Q9NSV4\"},{\"label\":\"Protein scribble homolog\",\"id\":\"Q14160\"},{\"label\":\"Ragulator complex protein LAMTOR1\",\"id\":\"Q6IAA8\"},{\"label\":\"Ras 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kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"Serine/threonine-protein kinase PAK 4\",\"id\":\"O96013\"},{\"label\":\"Sodium bicarbonate cotransporter 3\",\"id\":\"Q9Y6M7\"},{\"label\":\"Stomatin\",\"id\":\"P27105\"},{\"label\":\"Synaptosomal-associated protein 23\",\"id\":\"O00161\"},{\"label\":\"Transferrin receptor protein 1\",\"id\":\"P02786\"},{\"label\":\"Triple functional domain protein\",\"id\":\"O75962\"},{\"label\":\"Vang-like protein 1\",\"id\":\"Q8TAA9\"},{\"label\":\"Vesicle-associated membrane protein 3\",\"id\":\"Q15836\"},{\"label\":\"WAS/WASL-interacting protein family member 2\",\"id\":\"Q8TF74\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Cargo concentration in the ER", "protein_name": "[{\"label\":\"Alpha-1-antitrypsin\",\"id\":\"P01009\"},{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"CD59 glycoprotein\",\"id\":\"P13987\"},{\"label\":\"Cathepsin Z\",\"id\":\"Q9UBR2\"},{\"label\":\"Coagulation factor V\",\"id\":\"P12259\"},{\"label\":\"Coagulation factor VIII\",\"id\":\"P00451\"},{\"label\":\"Collagen alpha-1(VII) chain\",\"id\":\"Q02388\"},{\"label\":\"Dipeptidyl peptidase 1\",\"id\":\"P53634\"},{\"label\":\"Folate receptor alpha\",\"id\":\"P15328\"},{\"label\":\"Glutamate receptor 1\",\"id\":\"P42261\"},{\"label\":\"Golgi SNAP receptor complex member 2\",\"id\":\"O14653\"},{\"label\":\"Guanine nucleotide-exchange factor SEC12\",\"id\":\"Q9HCU5\"},{\"label\":\"Melanoma inhibitory activity protein 2\",\"id\":\"Q96PC5\"},{\"label\":\"Multiple coagulation factor deficiency protein 2\",\"id\":\"Q8NI22\"},{\"label\":\"Protein 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protein 1 homolog\",\"id\":\"Q5JRA6\"},{\"label\":\"VIP36-like protein\",\"id\":\"Q9H0V9\"},{\"label\":\"Vesicle-trafficking protein SEC22b\",\"id\":\"O75396\"},{\"label\":\"Vesicular integral-membrane protein VIP36\",\"id\":\"Q12907\"}]", "uniprot_id": "[\"O14653\",\"O75396\",\"O94855\",\"O95406\",\"O95486\",\"O95487\",\"P00451\",\"P01009\",\"P01135\",\"P12259\",\"P13987\",\"P15328\",\"P15514\",\"P42261\",\"P49257\",\"P49755\",\"P53634\",\"P53992\",\"Q02388\",\"Q12907\",\"Q13190\",\"Q15363\",\"Q15436\",\"Q5JRA6\",\"Q6PI25\",\"Q8NI22\",\"Q8TBE1\",\"Q96PC5\",\"Q9H0V9\",\"Q9HAT1\",\"Q9HCU5\",\"Q9UBR2\",\"Q9Y6B6\"]", "gene_symbol": 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circadian gene expression", "protein_name": "[{\"label\":\"3'-5' exoribonuclease HELZ2\",\"id\":\"Q9BYK8\"},{\"label\":\"Basic helix-loop-helix ARNT-like protein 1\",\"id\":\"O00327\"},{\"label\":\"Basic helix-loop-helix ARNT-like protein 2\",\"id\":\"Q8WYA1\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 9\",\"id\":\"Q3L8U1\"},{\"label\":\"Circadian locomoter output cycles protein kaput\",\"id\":\"O15516\"},{\"label\":\"Class E basic helix-loop-helix protein 40\",\"id\":\"O14503\"},{\"label\":\"Class E basic helix-loop-helix protein 41\",\"id\":\"Q9C0J9\"},{\"label\":\"Coagulation factor VII\",\"id\":\"P08709\"},{\"label\":\"D site-binding protein\",\"id\":\"Q10586\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Histone-arginine methyltransferase 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synthase\",\"id\":\"Q96RS0\"},{\"label\":\"Vasopressin-neurophysin 2-copeptin\",\"id\":\"P01185\"}]", "uniprot_id": "[\"O00327\",\"O14503\",\"O15516\",\"O60907\",\"P01185\",\"P05121\",\"P08709\",\"P19793\",\"P43490\",\"Q07869\",\"Q10586\",\"Q14686\",\"Q15596\",\"Q15648\",\"Q15788\",\"Q3L8U1\",\"Q6STE5\",\"Q86X55\",\"Q8WYA1\",\"Q92793\",\"Q96RS0\",\"Q99743\",\"Q9BYK8\",\"Q9BZK7\",\"Q9C0J9\",\"Q9UIH9\",\"Q9UK39\"]", "gene_symbol": 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4\",\"id\":\"P51582\"},{\"label\":\"P2Y purinoceptor 6\",\"id\":\"Q15077\"},{\"label\":\"Putative P2Y purinoceptor 10\",\"id\":\"O00398\"},{\"label\":\"Uracil nucleotide/cysteinyl leukotriene receptor\",\"id\":\"Q13304\"}]", "uniprot_id": "[\"O00398\",\"P41231\",\"P43657\",\"P47900\",\"P51582\",\"Q13304\",\"Q15077\",\"Q15391\",\"Q96G91\",\"Q99677\",\"Q9BPV8\",\"Q9H244\"]", "gene_symbol": "[\"GPR105\",\"GPR17\",\"GPR23\",\"GPR86\",\"GPR94\",\"HORK3\",\"KIAA0001\",\"LPA4\",\"LPAR4\",\"LPAR6\",\"NRU\",\"P2RU1\",\"P2RY1\",\"P2RY10\",\"P2RY11\",\"P2RY12\",\"P2RY13\",\"P2RY14\",\"P2RY2\",\"P2RY4\",\"P2RY5\",\"P2RY6\",\"P2RY9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Phosphorylation of CD3 and TCR zeta chains", "protein_name": "[{\"label\":\"HLA class II histocompatibility antigen, DP alpha 1 chain\",\"id\":\"P20036\"},{\"label\":\"HLA class II histocompatibility antigen, DP beta 1 chain\",\"id\":\"P04440\"},{\"label\":\"HLA class II histocompatibility antigen, DQ alpha 1 chain\",\"id\":\"P01909\"},{\"label\":\"HLA class II histocompatibility antigen, DQ alpha 2 chain\",\"id\":\"P01906\"},{\"label\":\"HLA class II histocompatibility antigen, DQ beta 1 chain\",\"id\":\"P01920\"},{\"label\":\"HLA class II histocompatibility antigen, DQ beta 2 chain\",\"id\":\"P05538\"},{\"label\":\"HLA class II histocompatibility antigen, DR alpha chain\",\"id\":\"P01903\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 3 chain\",\"id\":\"P79483\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 4 chain\",\"id\":\"P13762\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 5 chain\",\"id\":\"Q30154\"},{\"label\":\"HLA class II histocompatibility antigen, DRB1 beta chain\",\"id\":\"P01911\"},{\"label\":\"Phosphoprotein associated with glycosphingolipid-enriched microdomains 1\",\"id\":\"Q9NWQ8\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase C\",\"id\":\"P08575\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase eta\",\"id\":\"Q12913\"},{\"label\":\"T cell receptor alpha chain constant\",\"id\":\"P01848\"},{\"label\":\"T cell receptor alpha variable 19\",\"id\":\"A0A0A6YYK7\"},{\"label\":\"T cell receptor alpha variable 29/delta variable 5\",\"id\":\"P04437\"},{\"label\":\"T cell receptor alpha variable 8-4\",\"id\":\"P01737\"},{\"label\":\"T cell receptor beta constant 1\",\"id\":\"P01850\"},{\"label\":\"T cell receptor beta variable 12-3\",\"id\":\"P01733\"},{\"label\":\"T cell receptor beta variable 7-9\",\"id\":\"P04435\"},{\"label\":\"T-cell surface glycoprotein CD3 delta chain\",\"id\":\"P04234\"},{\"label\":\"T-cell surface glycoprotein CD3 epsilon chain\",\"id\":\"P07766\"},{\"label\":\"T-cell surface glycoprotein CD3 gamma chain\",\"id\":\"P09693\"},{\"label\":\"T-cell surface glycoprotein CD4\",\"id\":\"P01730\"},{\"label\":\"Tyrosine-protein kinase CSK\",\"id\":\"P41240\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein phosphatase 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mitochondrial\",\"id\":\"Q02338\"},{\"label\":\"Dehydrogenase/reductase SDR family member 6\",\"id\":\"Q9BUT1\"},{\"label\":\"Hydroxymethylglutaryl-CoA lyase, mitochondrial\",\"id\":\"P35914\"},{\"label\":\"Hydroxymethylglutaryl-CoA synthase, mitochondrial\",\"id\":\"P54868\"}]", "uniprot_id": "[\"P24752\",\"P35914\",\"P54868\",\"Q02338\",\"Q86V21\",\"Q8TB92\",\"Q9BUT1\",\"Q9H6R3\"]", "gene_symbol": "[\"AACS\",\"ACAT\",\"ACAT1\",\"ACSF1\",\"ACSS3\",\"BDH\",\"BDH1\",\"BDH2\",\"DHRS6\",\"HMGCL\",\"HMGCLL1\",\"HMGCS2\",\"MAT\",\"SDR15C1\",\"SDR9C1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nucleotide catabolism", "protein_name": "[{\"label\":\"Deoxynucleoside triphosphate triphosphohydrolase SAMHD1\",\"id\":\"Q9Y3Z3\"}]", "uniprot_id": "[\"Q9Y3Z3\"]", "gene_symbol": "[\"MOP5\",\"SAMHD1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Inhibition of TSC complex formation by PKB", "protein_name": "[{\"label\":\"Hamartin\",\"id\":\"Q92574\"},{\"label\":\"RAC-beta serine/threonine-protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)", "protein_name": "[{\"label\":\"Ferroportin\",\"id\":\"Q9NP59\"},{\"label\":\"Hephaestin\",\"id\":\"Q9BQS7\"}]", "uniprot_id": "[\"Q9BQS7\",\"Q9NP59\"]", "gene_symbol": "[\"FPN\",\"FPN1\",\"HEPH\",\"IREG1\",\"KIAA0698\",\"SLC11A3\",\"SLC40A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective pyroptosis", "protein_name": "[{\"label\":\"DNA (cytosine-5)-methyltransferase 1\",\"id\":\"P26358\"},{\"label\":\"DNA (cytosine-5)-methyltransferase 3A\",\"id\":\"Q9Y6K1\"},{\"label\":\"DNA (cytosine-5)-methyltransferase 3B\",\"id\":\"Q9UBC3\"},{\"label\":\"DNA polymerase alpha catalytic subunit\",\"id\":\"P09884\"},{\"label\":\"DNA polymerase alpha subunit B\",\"id\":\"Q14181\"},{\"label\":\"DNA primase large subunit\",\"id\":\"P49643\"},{\"label\":\"DNA primase small subunit\",\"id\":\"P49642\"},{\"label\":\"Gasdermin-E\",\"id\":\"O60443\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 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1\",\"id\":\"Q9H171\"}]", "uniprot_id": "[\"P0CG47\",\"P0CG48\",\"P19474\",\"P62979\",\"P62987\",\"Q13049\",\"Q14653\",\"Q86WV6\",\"Q96MN2\",\"Q9BRZ2\",\"Q9H171\",\"Q9UHD2\",\"Q9UJV9\",\"Q9Y2E6\"]", "gene_symbol": "[\"ABS\",\"C20orf183\",\"DDX41\",\"DLM1\",\"DTX4\",\"ERIS\",\"HT2A\",\"IRF3\",\"KIAA0937\",\"MITA\",\"NAK\",\"NALP4\",\"NLRP4\",\"PAN2\",\"PYPAF4\",\"RNF109\",\"RNF155\",\"RNF81\",\"RNH2\",\"RO52\",\"RPS27A\",\"SSA1\",\"STING\",\"STING1\",\"TBK1\",\"TMEM173\",\"TRIM21\",\"TRIM32\",\"TRIM56\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"ZBP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcriptional and post-translational regulation of MITF-M expression and activity", "protein_name": "[{\"label\":\"Adenosine 5'-monophosphoramidase HINT1\",\"id\":\"P49773\"},{\"label\":\"Aminoacyl tRNA synthase complex-interacting multifunctional protein 1\",\"id\":\"Q12904\"},{\"label\":\"Aminoacyl tRNA synthase complex-interacting multifunctional protein 2\",\"id\":\"Q13155\"},{\"label\":\"Arginine--tRNA ligase, cytoplasmic\",\"id\":\"P54136\"},{\"label\":\"Aspartate--tRNA ligase, cytoplasmic\",\"id\":\"P14868\"},{\"label\":\"Bifunctional glutamate/proline--tRNA ligase\",\"id\":\"P07814\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Cadherin-1\",\"id\":\"P12830\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"DNA-binding protein inhibitor ID-1\",\"id\":\"P41134\"},{\"label\":\"Endothelin receptor type B\",\"id\":\"P24530\"},{\"label\":\"Endothelin-1\",\"id\":\"P05305\"},{\"label\":\"Endothelin-3\",\"id\":\"P14138\"},{\"label\":\"Eukaryotic translation elongation factor 1 epsilon-1\",\"id\":\"O43324\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"Forkhead box protein D3\",\"id\":\"Q9UJU5\"},{\"label\":\"Glutamine--tRNA ligase\",\"id\":\"P47897\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Homeobox protein aristaless-like 3\",\"id\":\"O95076\"},{\"label\":\"Isoleucine--tRNA ligase, cytoplasmic\",\"id\":\"P41252\"},{\"label\":\"Leucine--tRNA ligase, cytoplasmic\",\"id\":\"Q9P2J5\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Lysine--tRNA ligase\",\"id\":\"Q15046\"},{\"label\":\"Mast/stem cell growth factor receptor Kit\",\"id\":\"P10721\"},{\"label\":\"Melanocortin receptor 3\",\"id\":\"P41968\"},{\"label\":\"Melanocortin receptor 4\",\"id\":\"P32245\"},{\"label\":\"Melanocortin receptor 5\",\"id\":\"P33032\"},{\"label\":\"Melanocyte-stimulating hormone receptor\",\"id\":\"Q01726\"},{\"label\":\"Methionine--tRNA ligase, cytoplasmic\",\"id\":\"P56192\"},{\"label\":\"Microphthalmia-associated transcription factor\",\"id\":\"O75030\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"NAD-dependent protein deacetylase sirtuin-1\",\"id\":\"Q96EB6\"},{\"label\":\"POU domain, class 3, transcription factor 2\",\"id\":\"P20265\"},{\"label\":\"Paired box protein Pax-3\",\"id\":\"P23760\"},{\"label\":\"Pro-opiomelanocortin\",\"id\":\"P01189\"},{\"label\":\"Protein Wnt-3a\",\"id\":\"P56704\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Ribosomal protein S6 kinase alpha-1\",\"id\":\"Q15418\"},{\"label\":\"T-box transcription factor TBX3\",\"id\":\"O15119\"},{\"label\":\"Transcription factor E3\",\"id\":\"P19532\"},{\"label\":\"Transcription factor EB\",\"id\":\"P19484\"},{\"label\":\"Transcription factor EC\",\"id\":\"O14948\"},{\"label\":\"Transcription factor SOX-10\",\"id\":\"P56693\"},{\"label\":\"Transcription factor SOX-2\",\"id\":\"P48431\"},{\"label\":\"Transcription factor SOX-9\",\"id\":\"P48436\"},{\"label\":\"Zinc finger protein SNAI2\",\"id\":\"O43623\"},{\"label\":\"Zinc finger protein ZIC 1\",\"id\":\"Q15915\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Ligand-receptor interactions", "protein_name": "[{\"label\":\"Brother of CDO\",\"id\":\"Q9BWV1\"},{\"label\":\"Cell adhesion molecule-related/down-regulated by oncogenes\",\"id\":\"Q4KMG0\"},{\"label\":\"Desert hedgehog protein\",\"id\":\"O43323\"},{\"label\":\"Growth arrest-specific protein 1\",\"id\":\"P54826\"},{\"label\":\"Hedgehog-interacting protein\",\"id\":\"Q96QV1\"},{\"label\":\"Indian hedgehog protein\",\"id\":\"Q14623\"},{\"label\":\"Protein patched homolog 1\",\"id\":\"Q13635\"},{\"label\":\"Sonic hedgehog protein\",\"id\":\"Q15465\"}]", "uniprot_id": "[\"O43323\",\"P54826\",\"Q13635\",\"Q14623\",\"Q15465\",\"Q4KMG0\",\"Q96QV1\",\"Q9BWV1\"]", "gene_symbol": "[\"BOC\",\"CDO\",\"CDON\",\"DHH\",\"GAS1\",\"HHIP\",\"HIP\",\"IHH\",\"PTCH\",\"PTCH1\",\"SHH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective gamma-carboxylation of F9", "protein_name": "[{\"label\":\"Coagulation factor IX\",\"id\":\"P00740\"},{\"label\":\"Vitamin K-dependent gamma-carboxylase\",\"id\":\"P38435\"}]", "uniprot_id": "[\"P00740\",\"P38435\"]", "gene_symbol": "[\"F9\",\"GC\",\"GGCX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ceritinib-resistant ALK mutants", "protein_name": "[{\"label\":\"ALK tyrosine kinase receptor\",\"id\":\"Q9UM73\"}]", "uniprot_id": "[\"Q9UM73\"]", "gene_symbol": "[\"ALK\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Eukaryotic Translation Termination", "protein_name": "[{\"label\":\"Acylamino-acid-releasing enzyme\",\"id\":\"P13798\"},{\"label\":\"Eukaryotic peptide chain release factor GTP-binding subunit ERF3A\",\"id\":\"P15170\"},{\"label\":\"Eukaryotic peptide chain release factor GTP-binding subunit ERF3B\",\"id\":\"Q8IYD1\"},{\"label\":\"Eukaryotic peptide chain release factor subunit 1\",\"id\":\"P62495\"},{\"label\":\"Large ribosomal subunit protein P1\",\"id\":\"P05386\"},{\"label\":\"Large ribosomal subunit protein P2\",\"id\":\"P05387\"},{\"label\":\"Large ribosomal subunit protein 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eL32\",\"id\":\"P62910\"},{\"label\":\"Large ribosomal subunit protein eL33\",\"id\":\"P18077\"},{\"label\":\"Large ribosomal subunit protein eL34\",\"id\":\"P49207\"},{\"label\":\"Large ribosomal subunit protein eL36\",\"id\":\"Q9Y3U8\"},{\"label\":\"Large ribosomal subunit protein eL37\",\"id\":\"P61927\"},{\"label\":\"Large ribosomal subunit protein eL38\",\"id\":\"P63173\"},{\"label\":\"Large ribosomal subunit protein eL39\",\"id\":\"P62891\"},{\"label\":\"Large ribosomal subunit protein eL42\",\"id\":\"P83881\"},{\"label\":\"Large ribosomal subunit protein eL43\",\"id\":\"P61513\"},{\"label\":\"Large ribosomal subunit protein eL6\",\"id\":\"Q02878\"},{\"label\":\"Large ribosomal subunit protein eL8\",\"id\":\"P62424\"},{\"label\":\"Large ribosomal subunit protein uL10\",\"id\":\"P05388\"},{\"label\":\"Large ribosomal subunit protein uL11\",\"id\":\"P30050\"},{\"label\":\"Large ribosomal subunit protein uL13\",\"id\":\"P40429\"},{\"label\":\"Large ribosomal subunit protein uL14\",\"id\":\"P62829\"},{\"label\":\"Large ribosomal subunit protein uL15\",\"id\":\"P46776\"},{\"label\":\"Large ribosomal subunit protein uL16\",\"id\":\"P27635\"},{\"label\":\"Large ribosomal subunit protein uL18\",\"id\":\"P46777\"},{\"label\":\"Large ribosomal subunit protein uL1\",\"id\":\"P62906\"},{\"label\":\"Large ribosomal subunit protein uL22\",\"id\":\"P18621\"},{\"label\":\"Large ribosomal subunit protein uL23\",\"id\":\"P62750\"},{\"label\":\"Large ribosomal subunit protein uL24\",\"id\":\"P61254\"},{\"label\":\"Large ribosomal subunit protein uL29\",\"id\":\"P42766\"},{\"label\":\"Large ribosomal subunit protein uL2\",\"id\":\"P62917\"},{\"label\":\"Large ribosomal subunit protein uL30\",\"id\":\"P18124\"},{\"label\":\"Large ribosomal subunit protein uL3\",\"id\":\"P39023\"},{\"label\":\"Large ribosomal subunit protein uL4\",\"id\":\"P36578\"},{\"label\":\"Large ribosomal subunit protein uL5\",\"id\":\"P62913\"},{\"label\":\"Large ribosomal subunit protein uL6\",\"id\":\"P32969\"},{\"label\":\"Methyltransferase N6AMT1\",\"id\":\"Q9Y5N5\"},{\"label\":\"Multifunctional methyltransferase subunit TRM112-like protein\",\"id\":\"Q9UI30\"},{\"label\":\"Ribosomal protein eL22-like\",\"id\":\"Q6P5R6\"},{\"label\":\"Ribosomal protein eL39-like 2\",\"id\":\"Q96EH5\"},{\"label\":\"Ribosomal protein eL42-like\",\"id\":\"Q969Q0\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Ribosomal protein uL16-like\",\"id\":\"Q96L21\"},{\"label\":\"Ribosomal protein uL24-like\",\"id\":\"Q9UNX3\"},{\"label\":\"Ribosomal protein uL3-like\",\"id\":\"Q92901\"},{\"label\":\"Small ribosomal subunit protein eS10\",\"id\":\"P46783\"},{\"label\":\"Small ribosomal subunit protein eS12\",\"id\":\"P25398\"},{\"label\":\"Small ribosomal subunit protein eS17\",\"id\":\"P08708\"},{\"label\":\"Small ribosomal subunit protein eS19\",\"id\":\"P39019\"},{\"label\":\"Small ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS32\",\"id\":\"P62945\"},{\"label\":\"Small ribosomal subunit protein eS4, X isoform\",\"id\":\"P62701\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 1\",\"id\":\"P22090\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 2\",\"id\":\"Q8TD47\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein eS7\",\"id\":\"P62081\"},{\"label\":\"Small ribosomal subunit protein eS8\",\"id\":\"P62241\"},{\"label\":\"Small ribosomal subunit protein 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uS9\",\"id\":\"P62249\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective ST3GAL3 causes MCT12 and EIEE15", "protein_name": "[{\"label\":\"Aggrecan core protein\",\"id\":\"P16112\"},{\"label\":\"CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase\",\"id\":\"Q11203\"},{\"label\":\"Fibromodulin\",\"id\":\"Q06828\"},{\"label\":\"Keratocan\",\"id\":\"O60938\"},{\"label\":\"Lumican\",\"id\":\"P51884\"},{\"label\":\"Mimecan\",\"id\":\"P20774\"},{\"label\":\"Osteomodulin\",\"id\":\"Q99983\"},{\"label\":\"Prolargin\",\"id\":\"P51888\"}]", "uniprot_id": "[\"O60938\",\"P16112\",\"P20774\",\"P51884\",\"P51888\",\"Q06828\",\"Q11203\",\"Q99983\"]", "gene_symbol": "[\"ACAN\",\"AGC1\",\"CSPG1\",\"FM\",\"FMOD\",\"KERA\",\"LDC\",\"LUM\",\"MSK16\",\"OGN\",\"OIF\",\"OMD\",\"PRELP\",\"SIAT6\",\"SLRR2A\",\"SLRR2B\",\"SLRR2C\",\"SLRR2D\",\"SLRR2E\",\"SLRR3A\",\"ST3GAL3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3", "protein_name": "[{\"label\":\"Dystroglycan 1\",\"id\":\"Q14118\"},{\"label\":\"Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1\",\"id\":\"Q8WZA1\"}]", "uniprot_id": "[\"Q14118\",\"Q8WZA1\"]", "gene_symbol": "[\"DAG1\",\"MGAT1.2\",\"POMGNT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "protein_name": "[{\"label\":\"Annexin A2\",\"id\":\"P07355\"},{\"label\":\"Calpain small subunit 1\",\"id\":\"P04632\"},{\"label\":\"Calpain small subunit 2\",\"id\":\"Q96L46\"},{\"label\":\"Calpain-2 catalytic subunit\",\"id\":\"P17655\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Guanine nucleotide-binding protein G(q) subunit alpha\",\"id\":\"P50148\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-11\",\"id\":\"P29992\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit epsilon\",\"id\":\"Q14164\"},{\"label\":\"Integrin alpha-5\",\"id\":\"P08648\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"NF-kappa-B inhibitor alpha\",\"id\":\"P25963\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Piezo-type mechanosensitive ion channel component 1\",\"id\":\"Q92508\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform\",\"id\":\"P63151\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"},{\"label\":\"Transcriptional coactivator YAP1\",\"id\":\"P46937\"},{\"label\":\"Tyrosine-protein kinase ABL1\",\"id\":\"P00519\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 1\",\"id\":\"P18031\"},{\"label\":\"Vinculin\",\"id\":\"P18206\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"P00519\",\"P04632\",\"P05106\",\"P05556\",\"P06756\",\"P07355\",\"P08648\",\"P17655\",\"P18031\",\"P18206\",\"P19838\",\"P25963\",\"P29992\",\"P30153\",\"P30154\",\"P42224\",\"P46937\",\"P50148\",\"P63151\",\"P67775\",\"Q04206\",\"Q05397\",\"Q14164\",\"Q92508\",\"Q96L46\",\"Q9Y6K9\"]", "gene_symbol": 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6A2, mitochondrial\",\"id\":\"Q02221\"},{\"label\":\"Cytochrome c oxidase subunit 6B1\",\"id\":\"P14854\"},{\"label\":\"Cytochrome c oxidase subunit 6B2\",\"id\":\"Q6YFQ2\"},{\"label\":\"Cytochrome c oxidase subunit 6C\",\"id\":\"P09669\"},{\"label\":\"Cytochrome c oxidase subunit 7A-related protein, mitochondrial\",\"id\":\"O14548\"},{\"label\":\"Cytochrome c oxidase subunit 7A1, mitochondrial\",\"id\":\"P24310\"},{\"label\":\"Cytochrome c oxidase subunit 7A2, mitochondrial\",\"id\":\"P14406\"},{\"label\":\"Cytochrome c oxidase subunit 7B, mitochondrial\",\"id\":\"P24311\"},{\"label\":\"Cytochrome c oxidase subunit 7C, mitochondrial\",\"id\":\"P15954\"},{\"label\":\"Cytochrome c oxidase subunit 8A, mitochondrial\",\"id\":\"P10176\"},{\"label\":\"Cytochrome c oxidase subunit 8C, mitochondrial\",\"id\":\"Q7Z4L0\"},{\"label\":\"Cytochrome c oxidase subunit NDUFA4\",\"id\":\"O00483\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Fatty acid-binding protein, liver\",\"id\":\"P07148\"},{\"label\":\"Flavin reductase (NADPH)\",\"id\":\"P30043\"},{\"label\":\"HIG1 domain family member 1C\",\"id\":\"A8MV81\"},{\"label\":\"Heme oxygenase 1\",\"id\":\"P09601\"},{\"label\":\"Heme oxygenase 2\",\"id\":\"P30519\"},{\"label\":\"Hemoglobin subunit alpha\",\"id\":\"P69905\"},{\"label\":\"Hemoglobin subunit beta\",\"id\":\"P68871\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone-arginine methyltransferase CARM1\",\"id\":\"Q86X55\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 1\",\"id\":\"Q15648\"},{\"label\":\"Multidrug resistance-associated protein 1\",\"id\":\"P33527\"},{\"label\":\"NACHT, LRR and PYD domains-containing protein 3\",\"id\":\"Q96P20\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Nuclear receptor coactivator 6\",\"id\":\"Q14686\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Paired amphipathic helix protein Sin3a\",\"id\":\"Q96ST3\"},{\"label\":\"Peroxisome proliferator-activated receptor alpha\",\"id\":\"Q07869\"},{\"label\":\"Protein-tyrosine kinase 6\",\"id\":\"Q13882\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3\",\"id\":\"Q6STE5\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal-transducing adaptor protein 2\",\"id\":\"Q9UGK3\"},{\"label\":\"Thioredoxin-interacting protein\",\"id\":\"Q9H3M7\"},{\"label\":\"Trimethylguanosine synthase\",\"id\":\"Q96RS0\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "MyD88 deficiency (TLR5)", "protein_name": "[{\"label\":\"Flagellin\",\"id\":\"P04949\"},{\"label\":\"Myeloid differentiation primary response protein MyD88\",\"id\":\"Q99836\"},{\"label\":\"Toll-like receptor 5\",\"id\":\"O60602\"}]", "uniprot_id": "[\"O60602\",\"P04949\",\"Q99836\"]", "gene_symbol": "[\"MYD88\",\"TIL3\",\"TLR5\",\"flaF\",\"fliC\",\"hag\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence", "protein_name": "[{\"label\":\"DNA ligase 1\",\"id\":\"P18858\"},{\"label\":\"Telomerase reverse transcriptase\",\"id\":\"O14746\"}]", "uniprot_id": "[\"O14746\",\"P18858\"]", "gene_symbol": "[\"EST2\",\"LIG1\",\"TCS1\",\"TERT\",\"TRT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cobalamin (Cbl) metabolism", "protein_name": "[{\"label\":\"Cobalamin trafficking protein CblD\",\"id\":\"Q9H3L0\"},{\"label\":\"Corrinoid adenosyltransferase MMAB\",\"id\":\"Q96EY8\"},{\"label\":\"Cyanocobalamin reductase / alkylcobalamin dealkylase\",\"id\":\"Q9Y4U1\"},{\"label\":\"Methionine synthase reductase\",\"id\":\"Q9UBK8\"},{\"label\":\"Methionine synthase\",\"id\":\"Q99707\"},{\"label\":\"Methylmalonic aciduria type A protein, mitochondrial\",\"id\":\"Q8IVH4\"},{\"label\":\"Methylmalonyl-CoA mutase, mitochondrial\",\"id\":\"P22033\"}]", "uniprot_id": "[\"P22033\",\"Q8IVH4\",\"Q96EY8\",\"Q99707\",\"Q9H3L0\",\"Q9UBK8\",\"Q9Y4U1\"]", "gene_symbol": "[\"C2orf25\",\"CL25022\",\"MMAA\",\"MMAB\",\"MMACHC\",\"MMADHC\",\"MMUT\",\"MTR\",\"MTRR\",\"MUT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of RNA Pol II elongation complex", "protein_name": "[{\"label\":\"AF4/FMR2 family member 4\",\"id\":\"Q9UHB7\"},{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-K\",\"id\":\"O75909\"},{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-T2\",\"id\":\"O60583\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"ELL-associated factor 1\",\"id\":\"Q96JC9\"},{\"label\":\"ELL-associated factor 2\",\"id\":\"Q96CJ1\"},{\"label\":\"Elongin-A2\",\"id\":\"Q8IYF1\"},{\"label\":\"Elongin-A\",\"id\":\"Q14241\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"FACT complex subunit SPT16\",\"id\":\"Q9Y5B9\"},{\"label\":\"FACT complex subunit SSRP1\",\"id\":\"Q08945\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Negative elongation factor A\",\"id\":\"Q9H3P2\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"},{\"label\":\"Negative elongation factor C/D\",\"id\":\"Q8IXH7\"},{\"label\":\"Negative elongation factor E\",\"id\":\"P18615\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Parafibromin\",\"id\":\"Q6P1J9\"},{\"label\":\"Protein 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incorporator 4\",\"id\":\"A6NH21\"},{\"label\":\"Serine incorporator 5\",\"id\":\"Q86VE9\"},{\"label\":\"Serine racemase\",\"id\":\"Q9GZT4\"}]", "uniprot_id": "[\"A6NH21\",\"O43175\",\"P78330\",\"Q13530\",\"Q86VE9\",\"Q96SA4\",\"Q9GZT4\",\"Q9NRX5\",\"Q9Y617\"]", "gene_symbol": "[\"C5orf12\",\"DIFF33\",\"KIAA1253\",\"PGDH3\",\"PHGDH\",\"PSA\",\"PSAT1\",\"PSPH\",\"SERINC1\",\"SERINC2\",\"SERINC3\",\"SERINC4\",\"SERINC5\",\"SRR\",\"TDE1\",\"TDE1L\",\"TDE2\",\"TDE2L\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PKR-mediated signaling", "protein_name": "[{\"label\":\"ATP-dependent RNA helicase A\",\"id\":\"Q08211\"},{\"label\":\"Alpha-synuclein\",\"id\":\"P37840\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Centromere protein S\",\"id\":\"Q8N2Z9\"},{\"label\":\"Centromere protein X\",\"id\":\"A8MT69\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"DnaJ homolog subfamily C member 3\",\"id\":\"Q13217\"},{\"label\":\"Double-stranded 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protein\",\"id\":\"O15360\"},{\"label\":\"Fanconi anemia group B protein\",\"id\":\"Q8NB91\"},{\"label\":\"Fanconi anemia group C protein\",\"id\":\"Q00597\"},{\"label\":\"Fanconi anemia group E protein\",\"id\":\"Q9HB96\"},{\"label\":\"Fanconi anemia group F protein\",\"id\":\"Q9NPI8\"},{\"label\":\"Fanconi anemia group G protein\",\"id\":\"O15287\"},{\"label\":\"Fanconi anemia group M protein\",\"id\":\"Q8IYD8\"},{\"label\":\"Heat shock 70 kDa protein 1-like\",\"id\":\"P34931\"},{\"label\":\"Heat shock 70 kDa protein 1A\",\"id\":\"P0DMV8\"},{\"label\":\"Heat shock 70 kDa protein 1B\",\"id\":\"P0DMV9\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Heat shock-related 70 kDa protein 2\",\"id\":\"P54652\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Interferon-induced, double-stranded RNA-activated protein kinase\",\"id\":\"P19525\"},{\"label\":\"Interferon-inducible double-stranded RNA-dependent protein kinase activator A\",\"id\":\"O75569\"},{\"label\":\"Interleukin enhancer-binding factor 2\",\"id\":\"Q12905\"},{\"label\":\"Interleukin enhancer-binding factor 3\",\"id\":\"Q12906\"},{\"label\":\"Mitochondrial antiviral-signaling protein\",\"id\":\"Q7Z434\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"Non-structural protein 1\",\"id\":\"P03496\"},{\"label\":\"Nucleophosmin\",\"id\":\"P06748\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03418\"},{\"label\":\"Protein TRS1\",\"id\":\"Q6SVX2\"},{\"label\":\"Protein Tat\",\"id\":\"P04609\"},{\"label\":\"RISC-loading complex subunit TARBP2\",\"id\":\"Q15633\"},{\"label\":\"SH2/SH3 adapter protein NCK1\",\"id\":\"P16333\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 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"gtc_id": "[\"\"]" }, { "pathway_label": "Sensory perception of salty taste", "protein_name": "[{\"label\":\"Amiloride-sensitive sodium channel subunit alpha\",\"id\":\"P37088\"},{\"label\":\"Amiloride-sensitive sodium channel subunit beta\",\"id\":\"P51168\"},{\"label\":\"Amiloride-sensitive sodium channel subunit delta\",\"id\":\"P51172\"},{\"label\":\"Amiloride-sensitive sodium channel subunit gamma\",\"id\":\"P51170\"},{\"label\":\"Calcium homeostasis modulator protein 1\",\"id\":\"Q8IU99\"},{\"label\":\"Calcium homeostasis modulator protein 3\",\"id\":\"Q86XJ0\"}]", "uniprot_id": "[\"P37088\",\"P51168\",\"P51170\",\"P51172\",\"Q86XJ0\",\"Q8IU99\"]", "gene_symbol": "[\"CALHM1\",\"CALHM3\",\"DNACH\",\"FAM26A\",\"FAM26C\",\"SCNN1\",\"SCNN1A\",\"SCNN1B\",\"SCNN1D\",\"SCNN1G\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "XBP1(S) activates chaperone genes", "protein_name": "[{\"label\":\"ADP-ribosylation factor GTPase-activating protein 1\",\"id\":\"Q8N6T3\"},{\"label\":\"ATP-dependent DNA helicase DDX11\",\"id\":\"Q96FC9\"},{\"label\":\"Alpha-adducin\",\"id\":\"P35611\"},{\"label\":\"CXXC-type zinc finger protein 1\",\"id\":\"Q9P0U4\"},{\"label\":\"Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2\",\"id\":\"O14595\"},{\"label\":\"Cullin-7\",\"id\":\"Q14999\"},{\"label\":\"Cytosolic phospholipase A2 beta\",\"id\":\"P0C869\"},{\"label\":\"DnaJ homolog subfamily B member 11\",\"id\":\"Q9UBS4\"},{\"label\":\"DnaJ homolog subfamily B member 9\",\"id\":\"Q9UBS3\"},{\"label\":\"DnaJ homolog subfamily C member 3\",\"id\":\"Q13217\"},{\"label\":\"Dynactin subunit 1\",\"id\":\"Q14203\"},{\"label\":\"E3 ubiquitin-protein ligase synoviolin\",\"id\":\"Q86TM6\"},{\"label\":\"ER degradation-enhancing alpha-mannosidase-like protein 1\",\"id\":\"Q92611\"},{\"label\":\"ER lumen protein-retaining receptor 3\",\"id\":\"O43731\"},{\"label\":\"Exostosin-like 1\",\"id\":\"Q92935\"},{\"label\":\"Exostosin-like 2\",\"id\":\"Q9UBQ6\"},{\"label\":\"Exostosin-like 3\",\"id\":\"O43909\"},{\"label\":\"Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1\",\"id\":\"Q06210\"},{\"label\":\"Glycogen synthase kinase-3 alpha\",\"id\":\"P49840\"},{\"label\":\"Golgi SNAP receptor complex member 2\",\"id\":\"O14653\"},{\"label\":\"Guanine nucleotide-exchange factor SEC12\",\"id\":\"Q9HCU5\"},{\"label\":\"Hepatoma-derived growth factor\",\"id\":\"P51858\"},{\"label\":\"Hypoxia up-regulated protein 1\",\"id\":\"Q9Y4L1\"},{\"label\":\"Kelch domain-containing protein 3\",\"id\":\"Q9BQ90\"},{\"label\":\"Myeloid-derived growth factor\",\"id\":\"Q969H8\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase FKBP14\",\"id\":\"Q9NWM8\"},{\"label\":\"Prelamin-A/C\",\"id\":\"P02545\"},{\"label\":\"Protein YIF1A\",\"id\":\"O95070\"},{\"label\":\"Protein disulfide-isomerase A5\",\"id\":\"Q14554\"},{\"label\":\"Protein disulfide-isomerase A6\",\"id\":\"Q15084\"},{\"label\":\"Protein transport protein Sec31A\",\"id\":\"O94979\"},{\"label\":\"Putative deoxyribonuclease TATDN2\",\"id\":\"Q93075\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Signal recognition particle receptor subunit alpha\",\"id\":\"P08240\"},{\"label\":\"Signal recognition particle receptor subunit beta\",\"id\":\"Q9Y5M8\"},{\"label\":\"Stress-associated endoplasmic reticulum protein 1\",\"id\":\"Q9Y6X1\"},{\"label\":\"Sulfotransferase 1A3\",\"id\":\"P0DMM9\"},{\"label\":\"Talin-1\",\"id\":\"Q9Y490\"},{\"label\":\"Testis-specific Y-encoded-like protein 2\",\"id\":\"Q9H2G4\"},{\"label\":\"Translocon-associated protein subunit alpha\",\"id\":\"P43307\"},{\"label\":\"Tripeptidyl-peptidase 1\",\"id\":\"O14773\"},{\"label\":\"V-type proton ATPase subunit d 1\",\"id\":\"P61421\"},{\"label\":\"Very long-chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P49748\"},{\"label\":\"WD repeat domain phosphoinositide-interacting protein 1\",\"id\":\"Q5MNZ9\"},{\"label\":\"Wolframin\",\"id\":\"O76024\"},{\"label\":\"Zinc finger and BTB domain-containing protein 17\",\"id\":\"Q13105\"}]", "uniprot_id": "[\"O14595\",\"O14653\",\"O14773\",\"O43731\",\"O43909\",\"O76024\",\"O94979\",\"O95070\",\"P02545\",\"P08240\",\"P0C869\",\"P0DMM9\",\"P29353\",\"P35611\",\"P43307\",\"P49748\",\"P49840\",\"P51858\",\"P61421\",\"Q06210\",\"Q13105\",\"Q13217\",\"Q14203\",\"Q14554\",\"Q14999\",\"Q15084\",\"Q15173\",\"Q5MNZ9\",\"Q86TM6\",\"Q8N6T3\",\"Q92611\",\"Q92935\",\"Q93075\",\"Q969H8\",\"Q96FC9\",\"Q9BQ90\",\"Q9H2G4\",\"Q9HCU5\",\"Q9NWM8\",\"Q9P0U4\",\"Q9UBQ6\",\"Q9UBS3\",\"Q9UBS4\",\"Q9Y490\",\"Q9Y4L1\",\"Q9Y5M8\",\"Q9Y6X1\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCB6 causes MCOPCB7", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family B member 6\",\"id\":\"Q9NP58\"}]", "uniprot_id": "[\"Q9NP58\"]", "gene_symbol": "[\"ABCB6\",\"MTABC3\",\"PRP\",\"UMAT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Tandem pore domain halothane-inhibited K+ channel (THIK)", "protein_name": "[{\"label\":\"Potassium channel subfamily K member 13\",\"id\":\"Q9HB14\"}]", "uniprot_id": "[\"Q9HB14\"]", "gene_symbol": "[\"KCNK13\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "GSD II", "protein_name": "[{\"label\":\"Glycogenin-1\",\"id\":\"P46976\"},{\"label\":\"Lysosomal alpha-glucosidase\",\"id\":\"P10253\"}]", "uniprot_id": "[\"P10253\",\"P46976\"]", "gene_symbol": "[\"GAA\",\"GYG\",\"GYG1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Translesion synthesis by POLK", "protein_name": "[{\"label\":\"DNA polymerase kappa\",\"id\":\"Q9UBT6\"},{\"label\":\"DNA polymerase zeta catalytic subunit\",\"id\":\"O60673\"},{\"label\":\"DNA repair protein REV1\",\"id\":\"Q9UBZ9\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2B\",\"id\":\"Q9UI95\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Replication factor C subunit 1\",\"id\":\"P35251\"},{\"label\":\"Replication factor C subunit 2\",\"id\":\"P35250\"},{\"label\":\"Replication factor C subunit 3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O60673\",\"P0CG47\",\"P0CG48\",\"P12004\",\"P15927\",\"P27694\",\"P35244\",\"P35249\",\"P35250\",\"P35251\",\"P40937\",\"P40938\",\"P62979\",\"P62987\",\"Q9UBT6\",\"Q9UBZ9\",\"Q9UI95\"]", "gene_symbol": "[\"DINB1\",\"MAD2B\",\"MAD2L2\",\"PCNA\",\"POLK\",\"POLZ\",\"REPA1\",\"REPA2\",\"REPA3\",\"REV1\",\"REV1L\",\"REV3\",\"REV3L\",\"REV7\",\"RFC1\",\"RFC140\",\"RFC2\",\"RFC3\",\"RFC4\",\"RFC5\",\"RPA1\",\"RPA14\",\"RPA2\",\"RPA3\",\"RPA32\",\"RPA34\",\"RPA70\",\"RPS27A\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of C3 and C5", "protein_name": "[{\"label\":\"Complement C2\",\"id\":\"P06681\"},{\"label\":\"Complement C3\",\"id\":\"P01024\"},{\"label\":\"Complement C4-A\",\"id\":\"P0C0L4\"},{\"label\":\"Complement C4-B\",\"id\":\"P0C0L5\"},{\"label\":\"Complement C5\",\"id\":\"P01031\"},{\"label\":\"Complement factor B\",\"id\":\"P00751\"}]", "uniprot_id": "[\"P00751\",\"P01024\",\"P01031\",\"P06681\",\"P0C0L4\",\"P0C0L5\"]", "gene_symbol": "[\"BF\",\"BFD\",\"C2\",\"C3\",\"C4A\",\"C4B\",\"C4B_2\",\"C5\",\"CFB\",\"CO4\",\"CPAMD1\",\"CPAMD2\",\"CPAMD3\",\"CPAMD4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Integration of provirus", "protein_name": "[{\"label\":\"Barrier-to-autointegration factor\",\"id\":\"O75531\"},{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"High mobility group protein HMG-I/HMG-Y\",\"id\":\"P17096\"},{\"label\":\"Importin subunit alpha-5\",\"id\":\"P52294\"},{\"label\":\"PC4 and SFRS1-interacting protein\",\"id\":\"O75475\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Protein Rev\",\"id\":\"P04618\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"O75475\",\"O75531\",\"P04585\",\"P04591\",\"P04618\",\"P05919\",\"P17096\",\"P52294\",\"P62937\",\"P69723\",\"P69726\"]", "gene_symbol": "[\"BAF\",\"BANF1\",\"BCRG1\",\"CYPA\",\"DFS70\",\"HMGA1\",\"HMGIY\",\"KPNA1\",\"LEDGF\",\"PPIA\",\"PSIP1\",\"PSIP2\",\"RCH2\",\"gag\",\"gag-pol\",\"rev\",\"vif\",\"vpr\",\"vpu\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "protein_name": "[{\"label\":\"Interleukin-1 receptor-associated kinase-like 2\",\"id\":\"O43187\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 7\",\"id\":\"O43318\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 1\",\"id\":\"Q15750\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2\",\"id\":\"Q9NYJ8\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 3\",\"id\":\"Q8N5C8\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"TIR domain-containing adapter molecule 2\",\"id\":\"Q86XR7\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00206\",\"O43187\",\"O43318\",\"P08571\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q15750\",\"Q86XR7\",\"Q8IUC6\",\"Q8N5C8\",\"Q9NYJ8\",\"Q9Y4K3\",\"Q9Y6Y9\"]", "gene_symbol": 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M2-1\",\"id\":\"P04545\"},{\"label\":\"Protein M2-2\",\"id\":\"P88812\"},{\"label\":\"RNA-directed RNA polymerase L\",\"id\":\"P28887\"}]", "uniprot_id": "[\"P03418\",\"P03421\",\"P04545\",\"P11142\",\"P28887\",\"P88812\"]", "gene_symbol": "[\"HSC70\",\"HSP73\",\"HSPA10\",\"HSPA8\",\"L\",\"M2-1\",\"M2-2\",\"N\",\"P\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of signaling by CBL", "protein_name": "[{\"label\":\"Adapter molecule crk\",\"id\":\"P46108\"},{\"label\":\"B-cell linker protein\",\"id\":\"Q8WV28\"},{\"label\":\"Crk-like protein\",\"id\":\"P46109\"},{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha 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"gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of diphthamide-EEF2", "protein_name": "[{\"label\":\"2-(3-amino-3-carboxypropyl)histidine synthase subunit 1\",\"id\":\"Q9BZG8\"},{\"label\":\"2-(3-amino-3-carboxypropyl)histidine synthase subunit 2\",\"id\":\"Q9BQC3\"},{\"label\":\"Diphthamide biosynthesis protein 3\",\"id\":\"Q96FX2\"},{\"label\":\"Diphthine methyl ester synthase\",\"id\":\"Q9H2P9\"},{\"label\":\"Diphthine methyltransferase\",\"id\":\"Q9BTV6\"},{\"label\":\"Diphthine--ammonia ligase\",\"id\":\"Q7L8W6\"},{\"label\":\"DnaJ homolog subfamily C member 24\",\"id\":\"Q6P3W2\"},{\"label\":\"Elongation factor 2\",\"id\":\"P13639\"}]", "uniprot_id": "[\"P13639\",\"Q6P3W2\",\"Q7L8W6\",\"Q96FX2\",\"Q9BQC3\",\"Q9BTV6\",\"Q9BZG8\",\"Q9H2P9\"]", "gene_symbol": "[\"ATPBD4\",\"C9orf112\",\"DESR1\",\"DNAJC24\",\"DPH1\",\"DPH2\",\"DPH2L\",\"DPH2L1\",\"DPH2L2\",\"DPH3\",\"DPH4\",\"DPH5\",\"DPH6\",\"DPH7\",\"EEF2\",\"EF2\",\"OVCA1\",\"WDR85\",\"ZCSL2\",\"ZCSL3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PTK6 Down-Regulation", "protein_name": "[{\"label\":\"Protein-tyrosine kinase 6\",\"id\":\"Q13882\"},{\"label\":\"Tyrosine-protein kinase Srms\",\"id\":\"Q9H3Y6\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 1\",\"id\":\"P18031\"}]", "uniprot_id": "[\"P18031\",\"Q13882\",\"Q9H3Y6\"]", "gene_symbol": "[\"BRK\",\"C20orf148\",\"PTK6\",\"PTP1B\",\"PTPN1\",\"SRMS\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Muscarinic acetylcholine receptors", "protein_name": "[{\"label\":\"Muscarinic acetylcholine receptor M1\",\"id\":\"P11229\"},{\"label\":\"Muscarinic acetylcholine receptor M2\",\"id\":\"P08172\"},{\"label\":\"Muscarinic acetylcholine receptor M3\",\"id\":\"P20309\"},{\"label\":\"Muscarinic acetylcholine receptor M4\",\"id\":\"P08173\"},{\"label\":\"Muscarinic acetylcholine receptor M5\",\"id\":\"P08912\"}]", "uniprot_id": "[\"P08172\",\"P08173\",\"P08912\",\"P11229\",\"P20309\"]", "gene_symbol": "[\"CHRM1\",\"CHRM2\",\"CHRM3\",\"CHRM4\",\"CHRM5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transferrin endocytosis and recycling", "protein_name": "[{\"label\":\"Hereditary hemochromatosis protein\",\"id\":\"Q30201\"},{\"label\":\"Metalloreductase STEAP3\",\"id\":\"Q658P3\"},{\"label\":\"Metalloreductase STEAP4\",\"id\":\"Q687X5\"},{\"label\":\"Mucolipin-1\",\"id\":\"Q9GZU1\"},{\"label\":\"Serotransferrin\",\"id\":\"P02787\"},{\"label\":\"Transferrin receptor protein 1\",\"id\":\"P02786\"},{\"label\":\"Transferrin receptor protein 2\",\"id\":\"Q9UP52\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 1\",\"id\":\"Q93050\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 2\",\"id\":\"Q9Y487\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 3\",\"id\":\"Q13488\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 4\",\"id\":\"Q9HBG4\"},{\"label\":\"V-type proton ATPase 16 kDa proteolipid subunit c\",\"id\":\"P27449\"},{\"label\":\"V-type proton ATPase 21 kDa proteolipid subunit c''\",\"id\":\"Q99437\"},{\"label\":\"V-type proton ATPase catalytic subunit A\",\"id\":\"P38606\"},{\"label\":\"V-type proton ATPase subunit B, brain isoform\",\"id\":\"P21281\"},{\"label\":\"V-type proton ATPase subunit B, kidney isoform\",\"id\":\"P15313\"},{\"label\":\"V-type proton ATPase subunit C 1\",\"id\":\"P21283\"},{\"label\":\"V-type proton ATPase subunit C 2\",\"id\":\"Q8NEY4\"},{\"label\":\"V-type proton ATPase subunit D\",\"id\":\"Q9Y5K8\"},{\"label\":\"V-type proton ATPase subunit E 1\",\"id\":\"P36543\"},{\"label\":\"V-type proton ATPase subunit E 2\",\"id\":\"Q96A05\"},{\"label\":\"V-type proton ATPase subunit F\",\"id\":\"Q16864\"},{\"label\":\"V-type proton ATPase subunit G 1\",\"id\":\"O75348\"},{\"label\":\"V-type proton ATPase subunit G 2\",\"id\":\"O95670\"},{\"label\":\"V-type proton ATPase subunit G 3\",\"id\":\"Q96LB4\"},{\"label\":\"V-type proton ATPase subunit H\",\"id\":\"Q9UI12\"},{\"label\":\"V-type proton ATPase subunit S1\",\"id\":\"Q15904\"},{\"label\":\"V-type proton ATPase subunit d 1\",\"id\":\"P61421\"},{\"label\":\"V-type proton ATPase subunit d 2\",\"id\":\"Q8N8Y2\"},{\"label\":\"V-type proton ATPase subunit e 1\",\"id\":\"O15342\"},{\"label\":\"V-type proton ATPase subunit e 2\",\"id\":\"Q8NHE4\"}]", "uniprot_id": "[\"O15342\",\"O75348\",\"O95670\",\"P02786\",\"P02787\",\"P15313\",\"P21281\",\"P21283\",\"P27449\",\"P36543\",\"P38606\",\"P61421\",\"Q13488\",\"Q15904\",\"Q16864\",\"Q30201\",\"Q658P3\",\"Q687X5\",\"Q8N8Y2\",\"Q8NEY4\",\"Q8NHE4\",\"Q93050\",\"Q96A05\",\"Q96LB4\",\"Q99437\",\"Q9GZU1\",\"Q9HBG4\",\"Q9UI12\",\"Q9UP52\",\"Q9Y487\",\"Q9Y5K8\"]", "gene_symbol": 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"protein_name": "[{\"label\":\"5-oxoprolinase\",\"id\":\"O14841\"},{\"label\":\"Cytosolic non-specific dipeptidase\",\"id\":\"Q96KP4\"},{\"label\":\"Gamma-glutamylcyclotransferase\",\"id\":\"O75223\"},{\"label\":\"Glutamate--cysteine ligase catalytic subunit\",\"id\":\"P48506\"},{\"label\":\"Glutamate--cysteine ligase regulatory subunit\",\"id\":\"P48507\"},{\"label\":\"Glutathione hydrolase 1 proenzyme\",\"id\":\"P19440\"},{\"label\":\"Glutathione hydrolase 5 proenzyme\",\"id\":\"P36269\"},{\"label\":\"Glutathione hydrolase 6\",\"id\":\"Q6P531\"},{\"label\":\"Glutathione hydrolase 7\",\"id\":\"Q9UJ14\"},{\"label\":\"Glutathione synthetase\",\"id\":\"P48637\"},{\"label\":\"Glutathione-specific gamma-glutamylcyclotransferase 1\",\"id\":\"Q9BUX1\"},{\"label\":\"Glutathione-specific gamma-glutamylcyclotransferase 2\",\"id\":\"Q8WUX2\"},{\"label\":\"Putative glutathione hydrolase 3 proenzyme\",\"id\":\"A6NGU5\"}]", "uniprot_id": 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kinase\",\"id\":\"Q9Y243\"}]", "uniprot_id": "[\"O95965\",\"P08648\",\"P31749\",\"P31751\",\"P45452\",\"Q13951\",\"Q9Y243\"]", "gene_symbol": "[\"AKT1\",\"AKT2\",\"AKT3\",\"CBFB\",\"FNRA\",\"ITGA5\",\"ITGBL1\",\"MMP13\",\"OSCP\",\"PKB\",\"PKBG\",\"RAC\",\"TIED\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Insulin effects increased synthesis of Xylulose-5-Phosphate", "protein_name": "[{\"label\":\"Transaldolase\",\"id\":\"P37837\"},{\"label\":\"Transketolase\",\"id\":\"P29401\"}]", "uniprot_id": "[\"P29401\",\"P37837\"]", "gene_symbol": "[\"TAL\",\"TALDO\",\"TALDO1\",\"TALDOR\",\"TKT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TRIF-mediated programmed cell death", "protein_name": "[{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"FAS-associated death domain protein\",\"id\":\"Q13158\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 3\",\"id\":\"Q9Y572\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"TIR domain-containing adapter molecule 2\",\"id\":\"Q86XR7\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"}]", "uniprot_id": "[\"O00206\",\"P08571\",\"Q13158\",\"Q13546\",\"Q14790\",\"Q86XR7\",\"Q8IUC6\",\"Q9Y572\",\"Q9Y6Y9\"]", "gene_symbol": "[\"CASP8\",\"CD14\",\"ESOP1\",\"FADD\",\"LY96\",\"MCH5\",\"MD2\",\"MORT1\",\"PRVTIRB\",\"RIP\",\"RIP1\",\"RIP3\",\"RIPK1\",\"RIPK3\",\"TICAM1\",\"TICAM2\",\"TIRAP3\",\"TIRP\",\"TLR4\",\"TRAM\",\"TRIF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Sunitinib-resistant KIT mutants", "protein_name": "[{\"label\":\"Mast/stem cell growth factor receptor Kit\",\"id\":\"P10721\"}]", "uniprot_id": "[\"P10721\"]", "gene_symbol": "[\"KIT\",\"SCFR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Phospholipase C-mediated cascade; FGFR2", 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"protein_name": "[{\"label\":\"Apoptotic protease-activating factor 1\",\"id\":\"O14727\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"},{\"label\":\"Cell division cycle 7-related protein kinase\",\"id\":\"O00311\"},{\"label\":\"Chromobox protein homolog 3\",\"id\":\"Q13185\"},{\"label\":\"Chromobox protein homolog 5\",\"id\":\"P45973\"},{\"label\":\"DNA endonuclease RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA repair protein RAD51 homolog 1\",\"id\":\"Q06609\"},{\"label\":\"E3 ubiquitin-protein ligase RING1\",\"id\":\"Q06587\"},{\"label\":\"E3 ubiquitin-protein ligase RING2\",\"id\":\"Q99496\"},{\"label\":\"Enhancer of polycomb homolog 1\",\"id\":\"Q9H2F5\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Histone-binding protein RBBP7\",\"id\":\"Q16576\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT1\",\"id\":\"Q9H9B1\"},{\"label\":\"Histone-lysine N-methyltransferase 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alpha-1\",\"id\":\"P25391\"},{\"label\":\"Laminin subunit alpha-2\",\"id\":\"P24043\"},{\"label\":\"Laminin subunit alpha-3\",\"id\":\"Q16787\"},{\"label\":\"Laminin subunit alpha-4\",\"id\":\"Q16363\"},{\"label\":\"Laminin subunit alpha-5\",\"id\":\"O15230\"},{\"label\":\"Laminin subunit beta-1\",\"id\":\"P07942\"},{\"label\":\"Laminin subunit beta-2\",\"id\":\"P55268\"},{\"label\":\"Laminin subunit beta-3\",\"id\":\"Q13751\"},{\"label\":\"Laminin subunit gamma-1\",\"id\":\"P11047\"},{\"label\":\"Laminin subunit gamma-2\",\"id\":\"Q13753\"},{\"label\":\"Laminin subunit gamma-3\",\"id\":\"Q9Y6N6\"},{\"label\":\"Netrin-4\",\"id\":\"Q9HB63\"},{\"label\":\"Neurexin-1\",\"id\":\"Q9ULB1\"},{\"label\":\"Platelet-derived growth factor subunit A\",\"id\":\"P04085\"},{\"label\":\"Platelet-derived growth factor subunit B\",\"id\":\"P01127\"},{\"label\":\"Transthyretin\",\"id\":\"P02766\"}]", "uniprot_id": 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beta-1\",\"id\":\"P05556\"},{\"label\":\"Plexin-A1\",\"id\":\"Q9UIW2\"},{\"label\":\"Plexin-A2\",\"id\":\"O75051\"},{\"label\":\"Plexin-A4\",\"id\":\"Q9HCM2\"},{\"label\":\"Plexin-B3\",\"id\":\"Q9ULL4\"},{\"label\":\"Plexin-C1\",\"id\":\"O60486\"},{\"label\":\"Plexin-D1\",\"id\":\"Q9Y4D7\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase C\",\"id\":\"P08575\"},{\"label\":\"Semaphorin-3E\",\"id\":\"O15041\"},{\"label\":\"Semaphorin-4A\",\"id\":\"Q9H3S1\"},{\"label\":\"Semaphorin-4D\",\"id\":\"Q92854\"},{\"label\":\"Semaphorin-5A\",\"id\":\"Q13591\"},{\"label\":\"Semaphorin-6A\",\"id\":\"Q9H2E6\"},{\"label\":\"Semaphorin-6D\",\"id\":\"Q8NFY4\"},{\"label\":\"Semaphorin-7A\",\"id\":\"O75326\"},{\"label\":\"TYRO protein tyrosine kinase-binding protein\",\"id\":\"O43914\"},{\"label\":\"Triggering receptor expressed on myeloid cells 2\",\"id\":\"Q9NZC2\"}]", "uniprot_id": 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apparatus protein 1\",\"id\":\"Q14980\"}]", "uniprot_id": "[\"P06493\",\"P14635\",\"Q14980\"]", "gene_symbol": "[\"CCNB\",\"CCNB1\",\"CDC2\",\"CDC28A\",\"CDK1\",\"CDKN1\",\"NMP22\",\"NUMA\",\"NUMA1\",\"P34CDC2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Long-term potentiation", "protein_name": "[{\"label\":\"Alpha-actinin-2\",\"id\":\"P35609\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Disks large homolog 1\",\"id\":\"Q12959\"},{\"label\":\"Disks large homolog 2\",\"id\":\"Q15700\"},{\"label\":\"Disks large homolog 3\",\"id\":\"Q92796\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Glutamate receptor 1\",\"id\":\"P42261\"},{\"label\":\"Glutamate receptor 2\",\"id\":\"P42262\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 1\",\"id\":\"Q05586\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2A\",\"id\":\"Q12879\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2C\",\"id\":\"Q14957\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2D\",\"id\":\"O15399\"},{\"label\":\"Leucine-rich repeat-containing protein 7\",\"id\":\"Q96NW7\"},{\"label\":\"Neurofilament light polypeptide\",\"id\":\"P07196\"},{\"label\":\"Neurogranin\",\"id\":\"Q92686\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"}]", "uniprot_id": "[\"O15399\",\"P07196\",\"P0DP23\",\"P12931\",\"P35609\",\"P42261\",\"P42262\",\"P78352\",\"Q02297\",\"Q05586\",\"Q12879\",\"Q12959\",\"Q13224\",\"Q13554\",\"Q13555\",\"Q13557\",\"Q14957\",\"Q15700\",\"Q92686\",\"Q92796\",\"Q96NW7\",\"Q9UQM7\"]", "gene_symbol": "[\"ACTN2\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAM2\",\"CAMK\",\"CAMK-II\",\"CAMK2\",\"CAMK2A\",\"CAMK2B\",\"CAMK2D\",\"CAMK2G\",\"CAMKA\",\"CAMKB\",\"CAMKD\",\"CAMKG\",\"DLG1\",\"DLG2\",\"DLG3\",\"DLG4\",\"GGF\",\"GLUA1\",\"GLUH1\",\"GLUR1\",\"GLUR2\",\"GRIA1\",\"GRIA2\",\"GRIN1\",\"GRIN2A\",\"GRIN2B\",\"GRIN2C\",\"GRIN2D\",\"GluA2\",\"GluN2D\",\"HGL\",\"HRGA\",\"KIAA0968\",\"KIAA1232\",\"KIAA1365\",\"LAP1\",\"LRRC7\",\"NDF\",\"NEFL\",\"NF68\",\"NFL\",\"NMDAR1\",\"NMDAR2A\",\"NMDAR2B\",\"NMDAR2C\",\"NMDAR2D\",\"NRG1\",\"NRGN\",\"PSD95\",\"SMDF\",\"SRC\",\"SRC1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Asparagine N-linked glycosylation", "protein_name": "[{\"label\":\"Asialoglycoprotein receptor 1\",\"id\":\"P07306\"},{\"label\":\"Asialoglycoprotein receptor 2\",\"id\":\"P07307\"},{\"label\":\"Beta-1,4 N-acetylgalactosaminyltransferase 2\",\"id\":\"Q8NHY0\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit\",\"id\":\"P39656\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1\",\"id\":\"P04843\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2\",\"id\":\"P04844\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1\",\"id\":\"P61803\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A\",\"id\":\"P46977\"},{\"label\":\"Magnesium transporter protein 1\",\"id\":\"Q9H0U3\"},{\"label\":\"Tumor suppressor candidate 3\",\"id\":\"Q13454\"},{\"label\":\"Uromodulin\",\"id\":\"P07911\"}]", "uniprot_id": 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2\",\"id\":\"Q9BSI4\"},{\"label\":\"Telomeric repeat-binding factor 1\",\"id\":\"P54274\"},{\"label\":\"Telomeric repeat-binding factor 2-interacting protein 1\",\"id\":\"Q9NYB0\"},{\"label\":\"Telomeric repeat-binding factor 2\",\"id\":\"Q15554\"}]", "uniprot_id": "[\"P09884\",\"P0CG13\",\"P12004\",\"P28340\",\"P35249\",\"P35250\",\"P35251\",\"P40937\",\"P40938\",\"P49005\",\"P49642\",\"P49643\",\"P54274\",\"Q14181\",\"Q15054\",\"Q15554\",\"Q2NKJ3\",\"Q86WV5\",\"Q8WVB6\",\"Q96AP0\",\"Q9BSI4\",\"Q9BVC3\",\"Q9H668\",\"Q9HCU8\",\"Q9NUX5\",\"Q9NYB0\"]", "gene_symbol": 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carrier family 2, facilitated glucose transporter member 2\",\"id\":\"P11168\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 3\",\"id\":\"P11169\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 4\",\"id\":\"P14672\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 6\",\"id\":\"Q9UGQ3\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 7\",\"id\":\"Q6PXP3\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 8\",\"id\":\"Q9NY64\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 9\",\"id\":\"Q9NRM0\"},{\"label\":\"Solute carrier family 45 member 3\",\"id\":\"Q96JT2\"},{\"label\":\"Sugar transporter SWEET1\",\"id\":\"Q9BRV3\"}]", "uniprot_id": 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"[{\"label\":\"Coagulation factor IX\",\"id\":\"P00740\"},{\"label\":\"Coagulation factor VII\",\"id\":\"P08709\"},{\"label\":\"Coagulation factor X\",\"id\":\"P00742\"},{\"label\":\"Tissue factor pathway inhibitor\",\"id\":\"P10646\"},{\"label\":\"Tissue factor\",\"id\":\"P13726\"}]", "uniprot_id": "[\"P00740\",\"P00742\",\"P08709\",\"P10646\",\"P13726\"]", "gene_symbol": "[\"F10\",\"F3\",\"F7\",\"F9\",\"LACI\",\"TFPI\",\"TFPI1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G2/M DNA damage checkpoint", "protein_name": "[{\"label\":\"ATR-interacting protein\",\"id\":\"Q8WXE1\"},{\"label\":\"BRCA1-A complex subunit Abraxas 1\",\"id\":\"Q6UWZ7\"},{\"label\":\"BRCA1-A complex subunit RAP80\",\"id\":\"Q96RL1\"},{\"label\":\"BRCA1-associated RING domain protein 1\",\"id\":\"Q99728\"},{\"label\":\"BRISC and BRCA1-A complex member 1\",\"id\":\"Q9NWV8\"},{\"label\":\"BRISC and BRCA1-A complex member 2\",\"id\":\"Q9NXR7\"},{\"label\":\"Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN\",\"id\":\"Q14191\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"},{\"label\":\"Cell cycle checkpoint control protein RAD9A\",\"id\":\"Q99638\"},{\"label\":\"Cell cycle checkpoint control protein RAD9B\",\"id\":\"Q6WBX8\"},{\"label\":\"Cell cycle checkpoint protein RAD17\",\"id\":\"O75943\"},{\"label\":\"Cell cycle checkpoint protein RAD1\",\"id\":\"O60671\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Checkpoint protein HUS1\",\"id\":\"O60921\"},{\"label\":\"DNA endonuclease RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA replication ATP-dependent helicase/nuclease DNA2\",\"id\":\"P51530\"},{\"label\":\"DNA topoisomerase 2-binding protein 1\",\"id\":\"Q92547\"},{\"label\":\"DNA topoisomerase 3-alpha\",\"id\":\"Q13472\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"E3 SUMO-protein ligase PIAS4\",\"id\":\"Q8N2W9\"},{\"label\":\"E3 ubiquitin-protein ligase HERC2\",\"id\":\"O95714\"},{\"label\":\"E3 ubiquitin-protein ligase RNF168\",\"id\":\"Q8IYW5\"},{\"label\":\"E3 ubiquitin-protein ligase RNF8\",\"id\":\"O76064\"},{\"label\":\"Exonuclease 1\",\"id\":\"Q9UQ84\"},{\"label\":\"Fanconi anemia group J protein\",\"id\":\"Q9BX63\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1t\",\"id\":\"Q16695\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Histone-lysine N-methyltransferase NSD2\",\"id\":\"O96028\"},{\"label\":\"Lys-63-specific deubiquitinase BRCC36\",\"id\":\"P46736\"},{\"label\":\"Mediator of DNA damage checkpoint protein 1\",\"id\":\"Q14676\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"RAD9, HUS1, RAD1-interacting nuclear orphan protein 1\",\"id\":\"Q9BSD3\"},{\"label\":\"RecQ-like DNA helicase BLM\",\"id\":\"P54132\"},{\"label\":\"RecQ-mediated genome instability protein 1\",\"id\":\"Q9H9A7\"},{\"label\":\"RecQ-mediated genome instability protein 2\",\"id\":\"Q96E14\"},{\"label\":\"Replication factor C subunit 2\",\"id\":\"P35250\"},{\"label\":\"Replication factor C subunit 3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"Serine/threonine-protein kinase ATR\",\"id\":\"Q13535\"},{\"label\":\"Serine/threonine-protein kinase Chk1\",\"id\":\"O14757\"},{\"label\":\"Serine/threonine-protein kinase Chk2\",\"id\":\"O96017\"},{\"label\":\"TP53-binding protein 1\",\"id\":\"Q12888\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 2\",\"id\":\"Q15819\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Vasopressin-like receptors", "protein_name": "[{\"label\":\"Oxytocin receptor\",\"id\":\"P30559\"},{\"label\":\"Oxytocin-neurophysin 1\",\"id\":\"P01178\"},{\"label\":\"Vasopressin V1a receptor\",\"id\":\"P37288\"},{\"label\":\"Vasopressin V1b receptor\",\"id\":\"P47901\"},{\"label\":\"Vasopressin V2 receptor\",\"id\":\"P30518\"},{\"label\":\"Vasopressin-neurophysin 2-copeptin\",\"id\":\"P01185\"}]", "uniprot_id": "[\"P01178\",\"P01185\",\"P30518\",\"P30559\",\"P37288\",\"P47901\"]", "gene_symbol": "[\"ADHR\",\"ARVP\",\"AVP\",\"AVPR1\",\"AVPR1A\",\"AVPR1B\",\"AVPR2\",\"AVPR3\",\"DIR\",\"DIR3\",\"OT\",\"OXT\",\"OXTR\",\"V2R\",\"VP\",\"VPR3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations", "protein_name": "[{\"label\":\"Death domain-associated protein 6\",\"id\":\"Q9UER7\"},{\"label\":\"Transcriptional regulator ATRX\",\"id\":\"P46100\"}]", "uniprot_id": "[\"P46100\",\"Q9UER7\"]", "gene_symbol": "[\"ATRX\",\"BING2\",\"DAP6\",\"DAXX\",\"RAD54L\",\"XH2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCC2 causes DJS", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 2\",\"id\":\"Q92887\"}]", "uniprot_id": "[\"Q92887\"]", "gene_symbol": "[\"ABCC2\",\"CMOAT\",\"CMOAT1\",\"CMRP\",\"MRP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"5'-3' exoribonuclease 1\",\"id\":\"Q8IZH2\"},{\"label\":\"Exosome complex component CSL4\",\"id\":\"Q9Y3B2\"},{\"label\":\"Exosome complex component MTR3\",\"id\":\"Q5RKV6\"},{\"label\":\"Exosome complex component RRP40\",\"id\":\"Q9NQT5\"},{\"label\":\"Exosome complex component RRP41\",\"id\":\"Q9NPD3\"},{\"label\":\"Exosome complex component RRP42\",\"id\":\"Q15024\"},{\"label\":\"Exosome complex component RRP43\",\"id\":\"Q96B26\"},{\"label\":\"Exosome complex component RRP45\",\"id\":\"Q06265\"},{\"label\":\"Exosome complex component RRP46\",\"id\":\"Q9NQT4\"},{\"label\":\"Exosome complex component RRP4\",\"id\":\"Q13868\"},{\"label\":\"Exosome complex exonuclease RRP44\",\"id\":\"Q9Y2L1\"},{\"label\":\"MAP kinase-activated protein kinase 2\",\"id\":\"P49137\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"m7GpppN-mRNA hydrolase\",\"id\":\"Q8IU60\"},{\"label\":\"mRNA decay activator protein ZFP36L1\",\"id\":\"Q07352\"},{\"label\":\"mRNA-decapping enzyme 1A\",\"id\":\"Q9NPI6\"}]", "uniprot_id": "[\"P31749\",\"P31946\",\"P49137\",\"Q06265\",\"Q07352\",\"Q13868\",\"Q15024\",\"Q5RKV6\",\"Q8IU60\",\"Q8IZH2\",\"Q96B26\",\"Q9NPD3\",\"Q9NPI6\",\"Q9NQT4\",\"Q9NQT5\",\"Q9Y2L1\",\"Q9Y3B2\"]", "gene_symbol": "[\"AKT1\",\"BERG36\",\"BRF1\",\"CML28\",\"CSL4\",\"DCP1A\",\"DCP2\",\"DIS3\",\"ERF1\",\"EXOSC1\",\"EXOSC2\",\"EXOSC3\",\"EXOSC4\",\"EXOSC5\",\"EXOSC6\",\"EXOSC7\",\"EXOSC8\",\"EXOSC9\",\"KIAA0116\",\"KIAA1008\",\"MAPKAPK2\",\"MTR3\",\"NUDT20\",\"OIP2\",\"PKB\",\"PMSCL1\",\"RAC\",\"RNF162B\",\"RRP4\",\"RRP40\",\"RRP41\",\"RRP42\",\"RRP43\",\"RRP44\",\"RRP46\",\"SEP1\",\"SKI6\",\"SMIF\",\"TIS11B\",\"XRN1\",\"YWHAB\",\"ZFP36L1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Inactivation of APC/C via direct inhibition of the APC/C complex", "protein_name": "[{\"label\":\"Anaphase-promoting complex subunit 10\",\"id\":\"Q9UM13\"},{\"label\":\"Anaphase-promoting complex subunit 11\",\"id\":\"Q9NYG5\"},{\"label\":\"Anaphase-promoting complex subunit 15\",\"id\":\"P60006\"},{\"label\":\"Anaphase-promoting complex subunit 16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 5\",\"id\":\"Q9UJX4\"},{\"label\":\"Anaphase-promoting complex subunit 7\",\"id\":\"Q9UJX3\"},{\"label\":\"Anaphase-promoting complex subunit CDC26\",\"id\":\"Q8NHZ8\"},{\"label\":\"Cell division cycle protein 16 homolog\",\"id\":\"Q13042\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Cell division cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Mitotic checkpoint protein BUB3\",\"id\":\"O43684\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta\",\"id\":\"O60566\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2A\",\"id\":\"Q13257\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"}]", "uniprot_id": "[\"O00762\",\"O43684\",\"O60566\",\"P30260\",\"P51668\",\"P51965\",\"P60006\",\"Q12834\",\"Q13042\",\"Q13257\",\"Q16763\",\"Q8NHZ8\",\"Q96DE5\",\"Q9H1A4\",\"Q9NYG5\",\"Q9UJX2\",\"Q9UJX3\",\"Q9UJX4\",\"Q9UJX5\",\"Q9UJX6\",\"Q9UM13\"]", "gene_symbol": "[\"ANAPC1\",\"ANAPC10\",\"ANAPC11\",\"ANAPC12\",\"ANAPC15\",\"ANAPC16\",\"ANAPC2\",\"ANAPC3\",\"ANAPC4\",\"ANAPC5\",\"ANAPC6\",\"ANAPC7\",\"ANAPC8\",\"APC10\",\"APC2\",\"APC4\",\"APC5\",\"APC7\",\"BUB1B\",\"BUB3\",\"BUBR1\",\"C10orf104\",\"C11orf51\",\"C9orf17\",\"CDC16\",\"CDC20\",\"CDC23\",\"CDC26\",\"CDC27\",\"CENP-27\",\"D0S1430E\",\"D17S978E\",\"E2EPF\",\"KIAA1406\",\"MAD2\",\"MAD2L1\",\"MAD3L\",\"SFT\",\"SSK1\",\"TSG24\",\"UBC5A\",\"UBCH10\",\"UBCH5\",\"UBCH5A\",\"UBCH6\",\"UBE2C\",\"UBE2D1\",\"UBE2E1\",\"UBE2S\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by FGFR1 in disease", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"BAG family molecular chaperone regulator 4\",\"id\":\"O95429\"},{\"label\":\"Breakpoint cluster region protein\",\"id\":\"P11274\"},{\"label\":\"Centrosomal protein 43\",\"id\":\"O95684\"},{\"label\":\"Cleavage and polyadenylation specificity factor subunit 6\",\"id\":\"Q16630\"},{\"label\":\"Erlin-2\",\"id\":\"O94905\"},{\"label\":\"FGFR1 oncogene partner 2\",\"id\":\"Q9NVK5\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 1\",\"id\":\"P11362\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Homeobox protein cut-like 1\",\"id\":\"P39880\"},{\"label\":\"Leucine-rich repeat flightless-interacting protein 1\",\"id\":\"Q32MZ4\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Transcription intermediary factor 1-alpha\",\"id\":\"O15164\"},{\"label\":\"Unconventional myosin-XVIIIa\",\"id\":\"Q92614\"},{\"label\":\"Zinc finger MYM-type protein 2\",\"id\":\"Q9UBW7\"}]", "uniprot_id": 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"Na+/Cl- dependent neurotransmitter transporters", "protein_name": "[{\"label\":\"Chromaffin granule amine transporter\",\"id\":\"P54219\"},{\"label\":\"Inactive sodium-dependent neutral amino acid transporter B(0)AT3\",\"id\":\"Q96N87\"},{\"label\":\"Sodium- and chloride-dependent GABA transporter 1\",\"id\":\"P30531\"},{\"label\":\"Sodium- and chloride-dependent GABA transporter 2\",\"id\":\"Q9NSD5\"},{\"label\":\"Sodium- and chloride-dependent GABA transporter 3\",\"id\":\"P48066\"},{\"label\":\"Sodium- and chloride-dependent betaine transporter\",\"id\":\"P48065\"},{\"label\":\"Sodium- and chloride-dependent glycine transporter 1\",\"id\":\"P48067\"},{\"label\":\"Sodium- and chloride-dependent glycine transporter 2\",\"id\":\"Q9Y345\"},{\"label\":\"Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)\",\"id\":\"Q9UN76\"},{\"label\":\"Sodium- and chloride-dependent taurine transporter\",\"id\":\"P31641\"},{\"label\":\"Sodium- and chloride-dependent transporter XTRP3\",\"id\":\"Q9NP91\"},{\"label\":\"Sodium-dependent dopamine transporter\",\"id\":\"Q01959\"},{\"label\":\"Sodium-dependent neutral amino acid transporter B(0)AT1\",\"id\":\"Q695T7\"},{\"label\":\"Sodium-dependent neutral amino acid transporter B(0)AT2\",\"id\":\"Q9H2J7\"},{\"label\":\"Sodium-dependent noradrenaline transporter\",\"id\":\"P23975\"},{\"label\":\"Sodium-dependent proline transporter\",\"id\":\"Q99884\"},{\"label\":\"Solute carrier family 22 member 1\",\"id\":\"O15245\"},{\"label\":\"Solute carrier family 22 member 2\",\"id\":\"O15244\"},{\"label\":\"Synaptic vesicular amine transporter\",\"id\":\"Q05940\"}]", "uniprot_id": "[\"O15244\",\"O15245\",\"P23975\",\"P30531\",\"P31641\",\"P48065\",\"P48066\",\"P48067\",\"P54219\",\"Q01959\",\"Q05940\",\"Q695T7\",\"Q96N87\",\"Q99884\",\"Q9H2J7\",\"Q9NP91\",\"Q9NSD5\",\"Q9UN76\",\"Q9Y345\"]", "gene_symbol": 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protein\",\"id\":\"Q92793\"},{\"label\":\"Hepatocyte nuclear factor 1-beta\",\"id\":\"P35680\"},{\"label\":\"Hepatocyte nuclear factor 6\",\"id\":\"Q9UBC0\"},{\"label\":\"Histone acetyltransferase KAT2A\",\"id\":\"Q92830\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Mastermind-like domain-containing protein 1\",\"id\":\"Q13495\"},{\"label\":\"Mastermind-like protein 1\",\"id\":\"Q92585\"},{\"label\":\"Mastermind-like protein 2\",\"id\":\"Q8IZL2\"},{\"label\":\"Mastermind-like protein 3\",\"id\":\"Q96JK9\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Neurogenin-3\",\"id\":\"Q9Y4Z2\"},{\"label\":\"One cut domain family member 3\",\"id\":\"O60422\"},{\"label\":\"Recombining binding protein suppressor of hairless\",\"id\":\"Q06330\"},{\"label\":\"SNW domain-containing protein 1\",\"id\":\"Q13573\"},{\"label\":\"Transcription factor HES-1\",\"id\":\"Q14469\"}]", "uniprot_id": "[\"O60422\",\"P35680\",\"P46531\",\"Q06330\",\"Q09472\",\"Q13495\",\"Q13573\",\"Q14469\",\"Q8IZL2\",\"Q92585\",\"Q92793\",\"Q92830\",\"Q92831\",\"Q96JK9\",\"Q9UBC0\",\"Q9Y4Z2\"]", "gene_symbol": "[\"ATOH5\",\"BHLHA7\",\"BHLHB39\",\"CBP\",\"CG1\",\"CREBBP\",\"CXorf6\",\"EP300\",\"GCN5\",\"GCN5L2\",\"HES1\",\"HL\",\"HNF1B\",\"HNF6\",\"HNF6A\",\"HRY\",\"IGKJRB\",\"IGKJRB1\",\"KAT2A\",\"KAT2B\",\"KIAA0200\",\"KIAA1816\",\"KIAA1819\",\"MAML1\",\"MAML2\",\"MAML3\",\"MAMLD1\",\"NEUROG3\",\"NGN3\",\"NOTCH1\",\"ONECUT1\",\"ONECUT3\",\"P300\",\"PCAF\",\"RBPJ\",\"RBPJK\",\"RBPSUH\",\"SKIIP\",\"SKIP\",\"SNW1\",\"TAN1\",\"TCF2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Scavenging by Class B Receptors", "protein_name": "[{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Platelet glycoprotein 4\",\"id\":\"P16671\"},{\"label\":\"Serum amyloid A-1 protein\",\"id\":\"P0DJI8\"},{\"label\":\"Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D\",\"id\":\"A1L4H1\"}]", "uniprot_id": "[\"A1L4H1\",\"P02647\",\"P04114\",\"P0DJI8\",\"P16671\"]", "gene_symbol": "[\"APOA1\",\"APOB\",\"CD36\",\"GP3B\",\"GP4\",\"SAA1\",\"SSC5D\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Packaging Of Telomere Ends", "protein_name": "[{\"label\":\"Adrenocortical dysplasia protein homolog\",\"id\":\"Q96AP0\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1t\",\"id\":\"Q16695\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Protection of telomeres protein 1\",\"id\":\"Q9NUX5\"},{\"label\":\"TERF1-interacting nuclear factor 2\",\"id\":\"Q9BSI4\"},{\"label\":\"Telomeric repeat-binding factor 1\",\"id\":\"P54274\"},{\"label\":\"Telomeric repeat-binding factor 2-interacting protein 1\",\"id\":\"Q9NYB0\"},{\"label\":\"Telomeric repeat-binding factor 2\",\"id\":\"Q15554\"}]", "uniprot_id": "[\"O60814\",\"P04908\",\"P06899\",\"P0C5Y9\",\"P16104\",\"P20671\",\"P23527\",\"P33778\",\"P54274\",\"P57053\",\"P58876\",\"P62805\",\"P62807\",\"Q15554\",\"Q16695\",\"Q16777\",\"Q16778\",\"Q6FI13\",\"Q71UI9\",\"Q8N257\",\"Q93077\",\"Q93079\",\"Q96A08\",\"Q96AP0\",\"Q99877\",\"Q99878\",\"Q99879\",\"Q99880\",\"Q9BSI4\",\"Q9BTM1\",\"Q9NUX5\",\"Q9NYB0\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "ERKs are inactivated", "protein_name": "[{\"label\":\"Dual specificity protein phosphatase 3\",\"id\":\"P51452\"},{\"label\":\"Dual specificity protein phosphatase 4\",\"id\":\"Q13115\"},{\"label\":\"Dual specificity protein phosphatase 6\",\"id\":\"Q16828\"},{\"label\":\"Dual specificity protein phosphatase 7\",\"id\":\"Q16829\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Mitogen-activated protein kinase 7\",\"id\":\"Q13164\"},{\"label\":\"Serine/threonine-protein kinase VRK3\",\"id\":\"Q8IV63\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"P27361\",\"P28482\",\"P30153\",\"P30154\",\"P51452\",\"P62714\",\"P67775\",\"Q13115\",\"Q13164\",\"Q14738\",\"Q16828\",\"Q16829\",\"Q8IV63\"]", "gene_symbol": "[\"BMK1\",\"DUSP3\",\"DUSP4\",\"DUSP6\",\"DUSP7\",\"ERK1\",\"ERK2\",\"ERK5\",\"MAPK1\",\"MAPK3\",\"MAPK7\",\"MKP2\",\"MKP3\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5D\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"PRKM7\",\"PYST1\",\"PYST2\",\"VH2\",\"VHR\",\"VRK3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "protein_name": "[{\"label\":\"DNA-directed RNA polymerase III subunit RPC10\",\"id\":\"Q9Y2Y1\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC1\",\"id\":\"O14802\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC2\",\"id\":\"Q9NW08\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC3\",\"id\":\"Q9BUI4\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC4\",\"id\":\"P05423\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC5\",\"id\":\"Q9NVU0\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC6\",\"id\":\"Q9H1D9\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7-like\",\"id\":\"Q9BT43\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7\",\"id\":\"O15318\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC8\",\"id\":\"Q9Y535\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC9\",\"id\":\"O75575\"},{\"label\":\"DNA-directed RNA polymerases I and III subunit RPAC1\",\"id\":\"O15160\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription factor 3C polypeptide 1\",\"id\":\"Q12789\"},{\"label\":\"General transcription factor 3C polypeptide 2\",\"id\":\"Q8WUA4\"},{\"label\":\"General transcription factor 3C polypeptide 3\",\"id\":\"Q9Y5Q9\"},{\"label\":\"General transcription factor 3C polypeptide 4\",\"id\":\"Q9UKN8\"},{\"label\":\"General transcription factor 3C polypeptide 5\",\"id\":\"Q9Y5Q8\"},{\"label\":\"General transcription factor 3C polypeptide 6\",\"id\":\"Q969F1\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription factor IIIA\",\"id\":\"Q92664\"},{\"label\":\"Transcription factor IIIB 90 kDa subunit\",\"id\":\"Q92994\"},{\"label\":\"Transcription factor TFIIIB component B'' homolog\",\"id\":\"A6H8Y1\"}]", "uniprot_id": "[\"A6H8Y1\",\"O14802\",\"O15160\",\"O15318\",\"O75575\",\"P05423\",\"P0DPB5\",\"P19388\",\"P20226\",\"P52434\",\"P53803\",\"P61218\",\"P62875\",\"Q12789\",\"Q8WUA4\",\"Q92664\",\"Q92994\",\"Q969F1\",\"Q9BT43\",\"Q9BUI4\",\"Q9H1D9\",\"Q9NVU0\",\"Q9NW08\",\"Q9UKN8\",\"Q9Y2Y1\",\"Q9Y535\",\"Q9Y5Q8\",\"Q9Y5Q9\"]", "gene_symbol": "[\"BDP1\",\"BN51\",\"BN51T\",\"BRF\",\"BRF1\",\"C6orf51\",\"CRCP\",\"GTF2D1\",\"GTF3A\",\"GTF3B\",\"GTF3C1\",\"GTF3C2\",\"GTF3C3\",\"GTF3C4\",\"GTF3C5\",\"GTF3C6\",\"KIAA0011\",\"KIAA1241\",\"KIAA1452\",\"KIAA1665\",\"KIAA1689\",\"POLR1C\",\"POLR1D\",\"POLR1E\",\"POLR2E\",\"POLR2F\",\"POLR2H\",\"POLR2K\",\"POLR2L\",\"POLR3A\",\"POLR3B\",\"POLR3C\",\"POLR3D\",\"POLR3E\",\"POLR3F\",\"POLR3G\",\"POLR3GL\",\"POLR3H\",\"POLR3K\",\"POLRF\",\"RPC11\",\"RPC8\",\"TAF3B2\",\"TAF3C\",\"TBP\",\"TF2D\",\"TFIID\",\"TFNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-3, Interleukin-5 and GM-CSF signaling", "protein_name": "[{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"Cytokine receptor common subunit beta\",\"id\":\"P32927\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor receptor subunit alpha\",\"id\":\"P15509\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor\",\"id\":\"P04141\"},{\"label\":\"Interleukin-3 receptor subunit alpha\",\"id\":\"P26951\"},{\"label\":\"Interleukin-3\",\"id\":\"P08700\"},{\"label\":\"Interleukin-5 receptor subunit alpha\",\"id\":\"Q01344\"},{\"label\":\"Interleukin-5\",\"id\":\"P05113\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform\",\"id\":\"O00329\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein kinase Tec\",\"id\":\"P42680\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"}]", "uniprot_id": "[\"O00329\",\"O00459\",\"O60674\",\"P04141\",\"P05113\",\"P08700\",\"P15498\",\"P15509\",\"P17612\",\"P26951\",\"P27986\",\"P29350\",\"P29353\",\"P32927\",\"P42229\",\"P42336\",\"P42338\",\"P42680\",\"P51692\",\"P63104\",\"Q01344\",\"Q06124\",\"Q92569\"]", "gene_symbol": "[\"CSF2\",\"CSF2R\",\"CSF2RA\",\"CSF2RB\",\"CSF2RY\",\"GMCSF\",\"GRB1\",\"HCP\",\"IL3\",\"IL3R\",\"IL3RA\",\"IL3RB\",\"IL5\",\"IL5R\",\"IL5RA\",\"IL5RB\",\"JAK2\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3CD\",\"PIK3R1\",\"PIK3R2\",\"PIK3R3\",\"PKACA\",\"PRKACA\",\"PSCTK4\",\"PTP1C\",\"PTP2C\",\"PTPN11\",\"PTPN6\",\"SHC\",\"SHC1\",\"SHCA\",\"SHPTP2\",\"STAT5\",\"STAT5A\",\"STAT5B\",\"TEC\",\"VAV\",\"VAV1\",\"YWHAZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by ERBB2 ECD mutants", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"P00533\",\"P01111\",\"P01112\",\"P01133\",\"P04626\",\"P07900\",\"P19174\",\"P27986\",\"P29353\",\"P42336\",\"Q07889\",\"Q13480\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"EGF\",\"EGFR\",\"ERBB\",\"ERBB1\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"GAB1\",\"GRB1\",\"HER1\",\"HER2\",\"HRAS\",\"HRAS1\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\",\"NRAS\",\"PIK3CA\",\"PIK3R1\",\"PLC1\",\"PLCG1\",\"SHC\",\"SHC1\",\"SHCA\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MPS IX - Natowicz syndrome", "protein_name": "[{\"label\":\"Hyaluronidase-1\",\"id\":\"Q12794\"}]", "uniprot_id": "[\"Q12794\"]", "gene_symbol": "[\"HYAL1\",\"LUCA1\"]", "gtc_id": "[\"G35674CY\"]" }, { "pathway_label": "MPS IIID - Sanfilippo syndrome D", "protein_name": "[{\"label\":\"N-acetylglucosamine-6-sulfatase\",\"id\":\"P15586\"}]", "uniprot_id": "[\"P15586\"]", "gene_symbol": "[\"GNS\"]", "gtc_id": "[\"G80016QC\"]" }, { "pathway_label": "Assembly and release of respiratory syncytial virus (RSV) virions", "protein_name": "[{\"label\":\"Fusion glycoprotein F0\",\"id\":\"P03420\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Matrix protein\",\"id\":\"P0DOE7\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03418\"},{\"label\":\"Phosphoprotein\",\"id\":\"P03421\"},{\"label\":\"Protein M2-1\",\"id\":\"P04545\"},{\"label\":\"RNA-directed RNA polymerase L\",\"id\":\"P28887\"}]", "uniprot_id": "[\"P03418\",\"P03420\",\"P03421\",\"P04545\",\"P07900\",\"P08238\",\"P0DOE7\",\"P28887\"]", "gene_symbol": "[\"F\",\"HSP90A\",\"HSP90AA1\",\"HSP90AB1\",\"HSP90B\",\"HSPC1\",\"HSPC2\",\"HSPC3\",\"HSPCA\",\"HSPCB\",\"L\",\"M\",\"M2-1\",\"N\",\"P\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ca2+ pathway", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1\",\"id\":\"Q9NQ66\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2\",\"id\":\"Q00722\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3\",\"id\":\"Q01970\"},{\"label\":\"Calcineurin subunit B type 1\",\"id\":\"P63098\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Frizzled-2\",\"id\":\"Q14332\"},{\"label\":\"Frizzled-3\",\"id\":\"Q9NPG1\"},{\"label\":\"Frizzled-4\",\"id\":\"Q9ULV1\"},{\"label\":\"Frizzled-5\",\"id\":\"Q13467\"},{\"label\":\"Frizzled-6\",\"id\":\"O60353\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(o) subunit alpha\",\"id\":\"P09471\"},{\"label\":\"Guanine nucleotide-binding protein G(t) subunit alpha-2\",\"id\":\"P19087\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1\",\"id\":\"Q14643\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2\",\"id\":\"Q14571\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3\",\"id\":\"Q14573\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 7\",\"id\":\"O43318\"},{\"label\":\"Nuclear factor of activated T-cells, cytoplasmic 1\",\"id\":\"O95644\"},{\"label\":\"Protein Wnt-11\",\"id\":\"O96014\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Protein phosphatase 3 catalytic subunit alpha\",\"id\":\"Q08209\"},{\"label\":\"Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma\",\"id\":\"P18545\"},{\"label\":\"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha\",\"id\":\"P16499\"},{\"label\":\"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta\",\"id\":\"P35913\"},{\"label\":\"Serine/threonine-protein kinase NLK\",\"id\":\"Q9UBE8\"},{\"label\":\"Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform\",\"id\":\"P16298\"},{\"label\":\"Transcription factor 7-like 1\",\"id\":\"Q9HCS4\"},{\"label\":\"Transcription factor 7-like 2\",\"id\":\"Q9NQB0\"},{\"label\":\"Transcription factor 7\",\"id\":\"P36402\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"},{\"label\":\"cGMP-dependent protein kinase 1\",\"id\":\"Q13976\"},{\"label\":\"cGMP-dependent protein kinase 2\",\"id\":\"Q13237\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O43318\",\"O60262\",\"O60353\",\"O95644\",\"O96014\",\"P09471\",\"P0DP23\",\"P16298\",\"P16499\",\"P16520\",\"P17252\",\"P18545\",\"P19087\",\"P35222\",\"P35913\",\"P36402\",\"P41221\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63098\",\"P63211\",\"P63215\",\"P63218\",\"Q00722\",\"Q01970\",\"Q08209\",\"Q13237\",\"Q13467\",\"Q13976\",\"Q14332\",\"Q14571\",\"Q14573\",\"Q14643\",\"Q8NDV7\",\"Q9H9G7\",\"Q9HAV0\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9HCS4\",\"Q9NPG1\",\"Q9NQ66\",\"Q9NQB0\",\"Q9P2W3\",\"Q9UBE8\",\"Q9UBI6\",\"Q9UJU2\",\"Q9UK08\",\"Q9UKV8\",\"Q9UL18\",\"Q9ULV1\",\"Q9UPQ9\",\"Q9UQM7\"]", "gene_symbol": "[\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"C2orf31\",\"CAGH26\",\"CALM\",\"CALM1\",\"CALNA\",\"CALNA2\",\"CALNB\",\"CAM\",\"CAM1\",\"CAMK2A\",\"CAMKA\",\"CNA\",\"CNA2\",\"CNB\",\"CTNNB\",\"CTNNB1\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"FZD2\",\"FZD3\",\"FZD4\",\"FZD5\",\"FZD6\",\"GNAO1\",\"GNAT2\",\"GNATC\",\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNB5\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT1\",\"GNGT10\",\"GNGT11\",\"GNGT2\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT8\",\"GNGT9\",\"INSP3R1\",\"ITPR1\",\"ITPR2\",\"ITPR3\",\"KIAA0581\",\"KIAA0968\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"KIAA1631\",\"LAK1\",\"LEF1\",\"MAP3K7\",\"MOV10\",\"NFAT2\",\"NFATC\",\"NFATC1\",\"NLK\",\"PDE6A\",\"PDE6B\",\"PDE6G\",\"PDEA\",\"PDEB\",\"PDEG\",\"PKCA\",\"PLCB1\",\"PLCB2\",\"PLCB3\",\"PPP3CA\",\"PPP3CB\",\"PPP3R1\",\"PRKACA\",\"PRKCA\",\"PRKG1\",\"PRKG1B\",\"PRKG2\",\"PRKGR1A\",\"PRKGR1B\",\"PRKGR2\",\"TAK1\",\"TCF1\",\"TCF3\",\"TCF4\",\"TCF7\",\"TCF7L1\",\"TCF7L2\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\",\"WNT11\",\"WNT5A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Neurotransmitter clearance", "protein_name": "[{\"label\":\"Acetylcholinesterase\",\"id\":\"P22303\"},{\"label\":\"Cholinesterase\",\"id\":\"P06276\"},{\"label\":\"Solute carrier family 22 member 1\",\"id\":\"O15245\"},{\"label\":\"Solute carrier family 22 member 2\",\"id\":\"O15244\"}]", "uniprot_id": "[\"O15244\",\"O15245\",\"P06276\",\"P22303\"]", "gene_symbol": "[\"ACHE\",\"BCHE\",\"CHE1\",\"OCT1\",\"OCT2\",\"SLC22A1\",\"SLC22A2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective CHST6 causes MCDC1", "protein_name": "[{\"label\":\"Aggrecan core protein\",\"id\":\"P16112\"},{\"label\":\"Carbohydrate sulfotransferase 6\",\"id\":\"Q9GZX3\"},{\"label\":\"Fibromodulin\",\"id\":\"Q06828\"},{\"label\":\"Keratocan\",\"id\":\"O60938\"},{\"label\":\"Lumican\",\"id\":\"P51884\"},{\"label\":\"Mimecan\",\"id\":\"P20774\"},{\"label\":\"Osteomodulin\",\"id\":\"Q99983\"},{\"label\":\"Prolargin\",\"id\":\"P51888\"}]", "uniprot_id": "[\"O60938\",\"P16112\",\"P20774\",\"P51884\",\"P51888\",\"Q06828\",\"Q99983\",\"Q9GZX3\"]", "gene_symbol": "[\"ACAN\",\"AGC1\",\"CHST6\",\"CSPG1\",\"FM\",\"FMOD\",\"KERA\",\"LDC\",\"LUM\",\"MSK16\",\"OGN\",\"OIF\",\"OMD\",\"PRELP\",\"SLRR2A\",\"SLRR2B\",\"SLRR2C\",\"SLRR2D\",\"SLRR2E\",\"SLRR3A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective CFTR causes cystic fibrosis", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Cystic fibrosis transmembrane conductance regulator\",\"id\":\"P13569\"},{\"label\":\"Derlin-1\",\"id\":\"Q9BUN8\"},{\"label\":\"Derlin-2\",\"id\":\"Q9GZP9\"},{\"label\":\"Derlin-3\",\"id\":\"Q96Q80\"},{\"label\":\"E3 ubiquitin-protein ligase RNF185\",\"id\":\"Q96GF1\"},{\"label\":\"E3 ubiquitin-protein ligase RNF5\",\"id\":\"Q99942\"},{\"label\":\"Endoplasmic reticulum lectin 1\",\"id\":\"Q96DZ1\"},{\"label\":\"Erlin-1\",\"id\":\"O75477\"},{\"label\":\"Erlin-2\",\"id\":\"O94905\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta 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"gtc_id": "[\"\"]" }, { "pathway_label": "ZBP1(DAI) mediated induction of type I IFNs", "protein_name": "[{\"label\":\"Z-DNA-binding protein 1\",\"id\":\"Q9H171\"}]", "uniprot_id": "[\"Q9H171\"]", "gene_symbol": "[\"C20orf183\",\"DLM1\",\"ZBP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Vpr-mediated nuclear import of PICs", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Barrier-to-autointegration factor\",\"id\":\"O75531\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"High mobility group protein HMG-I/HMG-Y\",\"id\":\"P17096\"},{\"label\":\"Importin subunit alpha-5\",\"id\":\"P52294\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein 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receptor\",\"id\":\"Q13018\"}]", "uniprot_id": "[\"O15496\",\"P04054\",\"P14555\",\"P39877\",\"P47712\",\"P53816\",\"Q13018\",\"Q3MJ16\",\"Q68DD2\",\"Q6P4A8\",\"Q86XP0\",\"Q96N66\",\"Q9BZM1\",\"Q9BZM2\",\"Q9NZK7\",\"Q9UNK4\",\"Q9UP65\"]", "gene_symbol": "[\"BB1\",\"CLEC13C\",\"CPLA2\",\"HRASLS3\",\"HREV107\",\"LENG4\",\"MBOAT7\",\"OACT7\",\"PLA2\",\"PLA2A\",\"PLA2B\",\"PLA2G10\",\"PLA2G12\",\"PLA2G12A\",\"PLA2G16\",\"PLA2G1B\",\"PLA2G2A\",\"PLA2G2D\",\"PLA2G2E\",\"PLA2G2F\",\"PLA2G4\",\"PLA2G4A\",\"PLA2G4C\",\"PLA2G4D\",\"PLA2G4E\",\"PLA2G4F\",\"PLA2G5\",\"PLA2L\",\"PLA2R1\",\"PLAAT3\",\"PLBD1\",\"PPLA2\",\"RASF-A\",\"SPLASH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HDL clearance", "protein_name": "[{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Cubilin\",\"id\":\"O60494\"},{\"label\":\"Protein amnionless\",\"id\":\"Q9BXJ7\"},{\"label\":\"Vigilin\",\"id\":\"Q00341\"}]", "uniprot_id": "[\"O60494\",\"P02647\",\"Q00341\",\"Q9BXJ7\"]", "gene_symbol": "[\"AMN\",\"APOA1\",\"CUBN\",\"HBP\",\"HDLBP\",\"IFCR\",\"VGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G-protein activation", "protein_name": "[{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(q) subunit alpha\",\"id\":\"P50148\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-11\",\"id\":\"P29992\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-14\",\"id\":\"O95837\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-15\",\"id\":\"P30679\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Mu-type opioid receptor\",\"id\":\"P35372\"},{\"label\":\"Pro-opiomelanocortin\",\"id\":\"P01189\"},{\"label\":\"Proenkephalin-B\",\"id\":\"P01213\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O60262\",\"O95837\",\"P01189\",\"P01213\",\"P16520\",\"P29992\",\"P30679\",\"P35372\",\"P50148\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63211\",\"P63215\",\"P63218\",\"Q9HAV0\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": 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multivesicular body protein 6\",\"id\":\"Q96FZ7\"},{\"label\":\"Charged multivesicular body protein 7\",\"id\":\"Q8WUX9\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 3B\",\"id\":\"Q9GZQ8\"},{\"label\":\"Phosphatidylinositol 3-kinase catalytic subunit type 3\",\"id\":\"Q8NEB9\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 4\",\"id\":\"Q99570\"},{\"label\":\"Replicase polyprotein 1a\",\"id\":\"P0DTC1\"},{\"label\":\"Replicase polyprotein 1ab\",\"id\":\"P0DTD1\"},{\"label\":\"UV radiation resistance-associated gene protein\",\"id\":\"Q9P2Y5\"}]", "uniprot_id": "[\"O43633\",\"P0DTC1\",\"P0DTD1\",\"Q14457\",\"Q8NEB9\",\"Q8WUX9\",\"Q96CF2\",\"Q96FZ7\",\"Q99570\",\"Q9BY43\",\"Q9GZQ8\",\"Q9H444\",\"Q9P2Y5\",\"Q9UQN3\",\"Q9Y3E7\"]", "gene_symbol": 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arrest-specific protein 6\",\"id\":\"Q14393\"},{\"label\":\"Osteocalcin\",\"id\":\"P02818\"},{\"label\":\"Prothrombin\",\"id\":\"P00734\"},{\"label\":\"Vitamin K-dependent protein C\",\"id\":\"P04070\"},{\"label\":\"Vitamin K-dependent protein S\",\"id\":\"P07225\"},{\"label\":\"Vitamin K-dependent protein Z\",\"id\":\"P22891\"}]", "uniprot_id": "[\"P00734\",\"P00740\",\"P00742\",\"P02818\",\"P04070\",\"P07225\",\"P08709\",\"P09958\",\"P22891\",\"Q14393\"]", "gene_symbol": "[\"AXLLG\",\"BGLAP\",\"F10\",\"F2\",\"F7\",\"F9\",\"FUR\",\"FURIN\",\"GAS6\",\"PACE\",\"PCSK3\",\"PROC\",\"PROS\",\"PROS1\",\"PROZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CD163 mediating an anti-inflammatory response", "protein_name": "[{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 17\",\"id\":\"P78536\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Inactive rhomboid protein 2\",\"id\":\"Q6PJF5\"},{\"label\":\"Interleukin-10\",\"id\":\"P22301\"},{\"label\":\"Interleukin-6\",\"id\":\"P05231\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Myosin-9\",\"id\":\"P35579\"},{\"label\":\"Scavenger receptor cysteine-rich type 1 protein M130\",\"id\":\"Q86VB7\"},{\"label\":\"Serine/threonine-protein kinase PLK2\",\"id\":\"Q9NYY3\"}]", "uniprot_id": "[\"P05231\",\"P09958\",\"P22301\",\"P35579\",\"P78536\",\"Q16539\",\"Q6PJF5\",\"Q86VB7\",\"Q9NYY3\"]", "gene_symbol": "[\"ADAM17\",\"CD163\",\"CSBP\",\"CSBP1\",\"CSBP2\",\"CSPB1\",\"CSVP\",\"FUR\",\"FURIN\",\"IFNB2\",\"IL10\",\"IL6\",\"IRHOM2\",\"M130\",\"MAPK14\",\"MXI2\",\"MYH9\",\"PACE\",\"PCSK3\",\"PLK2\",\"RHBDF2\",\"RHBDL5\",\"RHBDL6\",\"SAPK2A\",\"SNK\",\"TACE\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MicroRNA (miRNA) biogenesis", "protein_name": "[{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Endoribonuclease Dicer\",\"id\":\"Q9UPY3\"},{\"label\":\"Exportin-5\",\"id\":\"Q9HAV4\"},{\"label\":\"GTP-binding nuclear protein Ran\",\"id\":\"P62826\"},{\"label\":\"Interferon-inducible double-stranded RNA-dependent protein kinase activator A\",\"id\":\"O75569\"},{\"label\":\"Microprocessor complex subunit DGCR8\",\"id\":\"Q8WYQ5\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"RISC-loading complex subunit TARBP2\",\"id\":\"Q15633\"},{\"label\":\"RNA 5'-monophosphate methyltransferase\",\"id\":\"Q7Z5W3\"},{\"label\":\"Ribonuclease 3\",\"id\":\"Q9NRR4\"}]", "uniprot_id": 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protein\",\"id\":\"Q13158\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 6\",\"id\":\"P48023\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 6\",\"id\":\"P25445\"}]", "uniprot_id": "[\"P25445\",\"P48023\",\"Q13158\",\"Q14790\",\"Q92851\"]", "gene_symbol": "[\"APT1\",\"APT1LG1\",\"CASP10\",\"CASP8\",\"CD95L\",\"FADD\",\"FAS\",\"FAS1\",\"FASL\",\"FASLG\",\"MCH4\",\"MCH5\",\"MORT1\",\"TNFRSF6\",\"TNFSF6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)", "protein_name": "[{\"label\":\"Ammonium transporter Rh type A\",\"id\":\"Q02094\"}]", "uniprot_id": "[\"Q02094\"]", "gene_symbol": "[\"RH50\",\"RHAG\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX2 regulates osteoblast differentiation", "protein_name": "[{\"label\":\"Androgen receptor\",\"id\":\"P10275\"},{\"label\":\"Collagen alpha-1(I) chain\",\"id\":\"P02452\"},{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"DNA-binding protein SATB2\",\"id\":\"Q9UPW6\"},{\"label\":\"Hairy/enhancer-of-split related with YRPW motif protein 1\",\"id\":\"Q9Y5J3\"},{\"label\":\"Hairy/enhancer-of-split related with YRPW motif protein 2\",\"id\":\"Q9UBP5\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone deacetylase 6\",\"id\":\"Q9UBN7\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Osteocalcin\",\"id\":\"P02818\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Transcription factor HES-1\",\"id\":\"Q14469\"},{\"label\":\"Transcription factor Maf\",\"id\":\"O75444\"},{\"label\":\"Transcription factor Sp7\",\"id\":\"Q8TDD2\"},{\"label\":\"Transcriptional activator GLI3\",\"id\":\"P10071\"},{\"label\":\"Transcriptional coactivator YAP1\",\"id\":\"P46937\"},{\"label\":\"Tyrosine-protein kinase ABL1\",\"id\":\"P00519\"},{\"label\":\"Tyrosine-protein kinase Yes\",\"id\":\"P07947\"},{\"label\":\"Unique cartilage matrix-associated protein\",\"id\":\"Q8WVF2\"},{\"label\":\"WW domain-containing transcription regulator protein 1\",\"id\":\"Q9GZV5\"},{\"label\":\"Zinc finger protein 521\",\"id\":\"Q96K83\"}]", "uniprot_id": "[\"O15379\",\"O75444\",\"P00519\",\"P02452\",\"P02818\",\"P06400\",\"P07947\",\"P10071\",\"P10275\",\"P12931\",\"P27361\",\"P28482\",\"P46937\",\"Q13951\",\"Q14469\",\"Q8TDD2\",\"Q8WVF2\",\"Q96K83\",\"Q9GZV5\",\"Q9UBN7\",\"Q9UBP5\",\"Q9UPW6\",\"Q9Y5J3\"]", "gene_symbol": 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bL19m\",\"id\":\"P49406\"},{\"label\":\"Large ribosomal subunit protein bL20m\",\"id\":\"Q9BYC9\"},{\"label\":\"Large ribosomal subunit protein bL21m\",\"id\":\"Q7Z2W9\"},{\"label\":\"Large ribosomal subunit protein bL27m\",\"id\":\"Q9P0M9\"},{\"label\":\"Large ribosomal subunit protein bL28m\",\"id\":\"Q13084\"},{\"label\":\"Large ribosomal subunit protein bL32m\",\"id\":\"Q9BYC8\"},{\"label\":\"Large ribosomal subunit protein bL33m\",\"id\":\"O75394\"},{\"label\":\"Large ribosomal subunit protein bL34m\",\"id\":\"Q9BQ48\"},{\"label\":\"Large ribosomal subunit protein bL35m\",\"id\":\"Q9NZE8\"},{\"label\":\"Large ribosomal subunit protein bL36m\",\"id\":\"Q9P0J6\"},{\"label\":\"Large ribosomal subunit protein bL9m\",\"id\":\"Q9BYD2\"},{\"label\":\"Large ribosomal subunit protein mL37\",\"id\":\"Q9BZE1\"},{\"label\":\"Large ribosomal subunit protein mL38\",\"id\":\"Q96DV4\"},{\"label\":\"Large ribosomal subunit protein mL39\",\"id\":\"Q9NYK5\"},{\"label\":\"Large ribosomal subunit protein mL40\",\"id\":\"Q9NQ50\"},{\"label\":\"Large ribosomal subunit protein mL41\",\"id\":\"Q8IXM3\"},{\"label\":\"Large ribosomal subunit protein mL42\",\"id\":\"Q9Y6G3\"},{\"label\":\"Large ribosomal subunit protein mL43\",\"id\":\"Q8N983\"},{\"label\":\"Large ribosomal subunit protein mL44\",\"id\":\"Q9H9J2\"},{\"label\":\"Large ribosomal subunit protein mL45\",\"id\":\"Q9BRJ2\"},{\"label\":\"Large ribosomal subunit protein mL46\",\"id\":\"Q9H2W6\"},{\"label\":\"Large ribosomal subunit protein mL48\",\"id\":\"Q96GC5\"},{\"label\":\"Large ribosomal subunit protein mL49\",\"id\":\"Q13405\"},{\"label\":\"Large ribosomal subunit protein mL50\",\"id\":\"Q8N5N7\"},{\"label\":\"Large ribosomal subunit protein mL51\",\"id\":\"Q4U2R6\"},{\"label\":\"Large ribosomal subunit protein mL52\",\"id\":\"Q86TS9\"},{\"label\":\"Large ribosomal subunit protein mL53\",\"id\":\"Q96EL3\"},{\"label\":\"Large ribosomal subunit protein mL54\",\"id\":\"Q6P161\"},{\"label\":\"Large ribosomal subunit protein mL55\",\"id\":\"Q7Z7F7\"},{\"label\":\"Large ribosomal subunit protein mL62\",\"id\":\"Q14197\"},{\"label\":\"Large ribosomal subunit protein mL63\",\"id\":\"Q9BQC6\"},{\"label\":\"Large ribosomal subunit protein mL64\",\"id\":\"Q8TAE8\"},{\"label\":\"Large ribosomal subunit protein mL65\",\"id\":\"Q9NP92\"},{\"label\":\"Large ribosomal subunit protein mL66\",\"id\":\"Q9NVS2\"},{\"label\":\"Large ribosomal subunit protein uL10m\",\"id\":\"Q7Z7H8\"},{\"label\":\"Large ribosomal subunit protein uL11m\",\"id\":\"Q9Y3B7\"},{\"label\":\"Large ribosomal subunit protein uL13m\",\"id\":\"Q9BYD1\"},{\"label\":\"Large ribosomal subunit protein uL14m\",\"id\":\"Q6P1L8\"},{\"label\":\"Large ribosomal subunit protein uL15m\",\"id\":\"Q9P015\"},{\"label\":\"Large ribosomal subunit protein uL16m\",\"id\":\"Q9NX20\"},{\"label\":\"Large ribosomal subunit protein uL18m\",\"id\":\"Q9H0U6\"},{\"label\":\"Large ribosomal subunit protein uL1m\",\"id\":\"Q9BYD6\"},{\"label\":\"Large ribosomal subunit protein uL22m\",\"id\":\"Q9NWU5\"},{\"label\":\"Large ribosomal subunit protein uL23m\",\"id\":\"Q16540\"},{\"label\":\"Large ribosomal subunit protein uL24m\",\"id\":\"Q96A35\"},{\"label\":\"Large ribosomal subunit protein uL29m\",\"id\":\"Q9HD33\"},{\"label\":\"Large ribosomal subunit protein uL2m\",\"id\":\"Q5T653\"},{\"label\":\"Large ribosomal subunit protein uL30m\",\"id\":\"Q8TCC3\"},{\"label\":\"Large ribosomal subunit protein uL3m\",\"id\":\"P09001\"},{\"label\":\"Large ribosomal subunit protein uL4m\",\"id\":\"Q9BYD3\"},{\"label\":\"Mitochondrial inner membrane protein OXA1L\",\"id\":\"Q15070\"},{\"label\":\"Peptide chain release factor 1-like, mitochondrial\",\"id\":\"Q9UGC7\"},{\"label\":\"Ribosome-recycling factor, mitochondrial\",\"id\":\"Q96E11\"},{\"label\":\"Ribosome-releasing factor 2, mitochondrial\",\"id\":\"Q969S9\"},{\"label\":\"Small ribosomal subunit protein bS16m\",\"id\":\"Q9Y3D3\"},{\"label\":\"Small ribosomal subunit protein 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uS9m\",\"id\":\"P82933\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Transcriptional regulation by small RNAs", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"GTP-binding nuclear protein Ran\",\"id\":\"P62826\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H3.3\",\"id\":\"P84243\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Importin-8\",\"id\":\"O15397\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin 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2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa 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p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 11\",\"id\":\"Q96DB2\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone deacetylase 2\",\"id\":\"Q92769\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone deacetylase 4\",\"id\":\"P56524\"},{\"label\":\"Histone deacetylase 5\",\"id\":\"Q9UQL6\"},{\"label\":\"Histone deacetylase 6\",\"id\":\"Q9UBN7\"},{\"label\":\"Histone deacetylase 7\",\"id\":\"Q8WUI4\"},{\"label\":\"Histone deacetylase 8\",\"id\":\"Q9BY41\"},{\"label\":\"Histone deacetylase 9\",\"id\":\"Q9UKV0\"},{\"label\":\"Mastermind-like domain-containing protein 1\",\"id\":\"Q13495\"},{\"label\":\"Mastermind-like protein 1\",\"id\":\"Q92585\"},{\"label\":\"Mastermind-like protein 2\",\"id\":\"Q8IZL2\"},{\"label\":\"Mastermind-like protein 3\",\"id\":\"Q96JK9\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Nicastrin\",\"id\":\"Q92542\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Polyamine deacetylase HDAC10\",\"id\":\"Q969S8\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Presenilin-1\",\"id\":\"P49768\"},{\"label\":\"Presenilin-2\",\"id\":\"P49810\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Protein jagged-2\",\"id\":\"Q9Y219\"},{\"label\":\"Recombining binding protein suppressor of hairless\",\"id\":\"Q06330\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"SNW domain-containing protein 1\",\"id\":\"Q13573\"},{\"label\":\"Transcription factor HES-1\",\"id\":\"Q14469\"},{\"label\":\"Transcription factor HES-5\",\"id\":\"Q5TA89\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"A8MQ27\",\"O00548\",\"O14672\",\"O15379\",\"O60907\",\"O75376\",\"O76050\",\"P01106\",\"P0CG47\",\"P0CG48\",\"P24863\",\"P46531\",\"P49336\",\"P49768\",\"P49810\",\"P56524\",\"P62877\",\"P62979\",\"P62987\",\"P63208\",\"P78504\",\"P78536\",\"Q06330\",\"Q09472\",\"Q13495\",\"Q13547\",\"Q13573\",\"Q13616\",\"Q14469\",\"Q5TA89\",\"Q86YT6\",\"Q8IZL2\",\"Q8WUI4\",\"Q8WW43\",\"Q92542\",\"Q92585\",\"Q92769\",\"Q92793\",\"Q92830\",\"Q92831\",\"Q969S8\",\"Q96AX9\",\"Q96BI3\",\"Q96DB2\",\"Q96JK9\",\"Q9BY41\",\"Q9BZK7\",\"Q9NQ87\",\"Q9NR61\",\"Q9NZ42\",\"Q9UBN7\",\"Q9UBP5\",\"Q9UKV0\",\"Q9UQL6\",\"Q9Y219\",\"Q9Y5J3\",\"Q9Y618\"]", "gene_symbol": 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translation initiation", "protein_name": "[{\"label\":\"Alpha-ketoglutarate dehydrogenase component 4\",\"id\":\"P82909\"},{\"label\":\"GTPase Era, mitochondrial\",\"id\":\"O75616\"},{\"label\":\"Large ribosomal subunit protein bL12m\",\"id\":\"P52815\"},{\"label\":\"Large ribosomal subunit protein bL17m\",\"id\":\"Q9NRX2\"},{\"label\":\"Large ribosomal subunit protein bL19m\",\"id\":\"P49406\"},{\"label\":\"Large ribosomal subunit protein bL20m\",\"id\":\"Q9BYC9\"},{\"label\":\"Large ribosomal subunit protein bL21m\",\"id\":\"Q7Z2W9\"},{\"label\":\"Large ribosomal subunit protein bL27m\",\"id\":\"Q9P0M9\"},{\"label\":\"Large ribosomal subunit protein bL28m\",\"id\":\"Q13084\"},{\"label\":\"Large ribosomal subunit protein bL32m\",\"id\":\"Q9BYC8\"},{\"label\":\"Large ribosomal subunit protein bL33m\",\"id\":\"O75394\"},{\"label\":\"Large ribosomal subunit protein bL34m\",\"id\":\"Q9BQ48\"},{\"label\":\"Large ribosomal subunit protein bL35m\",\"id\":\"Q9NZE8\"},{\"label\":\"Large ribosomal subunit protein bL36m\",\"id\":\"Q9P0J6\"},{\"label\":\"Large ribosomal subunit protein bL9m\",\"id\":\"Q9BYD2\"},{\"label\":\"Large ribosomal subunit protein mL37\",\"id\":\"Q9BZE1\"},{\"label\":\"Large ribosomal subunit protein mL38\",\"id\":\"Q96DV4\"},{\"label\":\"Large ribosomal subunit protein mL39\",\"id\":\"Q9NYK5\"},{\"label\":\"Large ribosomal subunit protein mL40\",\"id\":\"Q9NQ50\"},{\"label\":\"Large ribosomal subunit protein mL41\",\"id\":\"Q8IXM3\"},{\"label\":\"Large ribosomal subunit protein mL42\",\"id\":\"Q9Y6G3\"},{\"label\":\"Large ribosomal subunit protein mL43\",\"id\":\"Q8N983\"},{\"label\":\"Large ribosomal subunit protein mL44\",\"id\":\"Q9H9J2\"},{\"label\":\"Large ribosomal subunit protein mL45\",\"id\":\"Q9BRJ2\"},{\"label\":\"Large ribosomal subunit protein mL46\",\"id\":\"Q9H2W6\"},{\"label\":\"Large ribosomal subunit protein mL48\",\"id\":\"Q96GC5\"},{\"label\":\"Large ribosomal subunit protein mL49\",\"id\":\"Q13405\"},{\"label\":\"Large ribosomal subunit protein mL50\",\"id\":\"Q8N5N7\"},{\"label\":\"Large ribosomal subunit protein mL51\",\"id\":\"Q4U2R6\"},{\"label\":\"Large ribosomal subunit protein mL52\",\"id\":\"Q86TS9\"},{\"label\":\"Large ribosomal subunit protein mL53\",\"id\":\"Q96EL3\"},{\"label\":\"Large ribosomal subunit protein mL54\",\"id\":\"Q6P161\"},{\"label\":\"Large ribosomal subunit protein mL55\",\"id\":\"Q7Z7F7\"},{\"label\":\"Large ribosomal subunit protein mL62\",\"id\":\"Q14197\"},{\"label\":\"Large ribosomal subunit protein mL63\",\"id\":\"Q9BQC6\"},{\"label\":\"Large ribosomal subunit protein mL64\",\"id\":\"Q8TAE8\"},{\"label\":\"Large ribosomal subunit protein mL65\",\"id\":\"Q9NP92\"},{\"label\":\"Large ribosomal subunit protein mL66\",\"id\":\"Q9NVS2\"},{\"label\":\"Large ribosomal subunit protein uL10m\",\"id\":\"Q7Z7H8\"},{\"label\":\"Large ribosomal subunit protein uL11m\",\"id\":\"Q9Y3B7\"},{\"label\":\"Large ribosomal subunit protein uL13m\",\"id\":\"Q9BYD1\"},{\"label\":\"Large 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1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"Serine/threonine-protein kinase PAK 4\",\"id\":\"O96013\"},{\"label\":\"Signal transducing adapter molecule 1\",\"id\":\"Q92783\"},{\"label\":\"Signal transducing adapter molecule 2\",\"id\":\"O75886\"},{\"label\":\"Spectrin alpha chain, non-erythrocytic 1\",\"id\":\"Q13813\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 1\",\"id\":\"Q01082\"},{\"label\":\"Thioredoxin-like protein 1\",\"id\":\"O43396\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 9X\",\"id\":\"Q93008\"},{\"label\":\"Unconventional myosin-VI\",\"id\":\"Q9UM54\"},{\"label\":\"Vang-like protein 1\",\"id\":\"Q8TAA9\"},{\"label\":\"tRNA (34-2'-O)-methyltransferase regulator WDR6\",\"id\":\"Q9NNW5\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Cardiogenesis", "protein_name": "[{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Eomesodermin homolog\",\"id\":\"O95936\"},{\"label\":\"Forkhead box protein O4\",\"id\":\"P98177\"},{\"label\":\"Hairy/enhancer-of-split related with YRPW motif protein 1\",\"id\":\"Q9Y5J3\"},{\"label\":\"Hairy/enhancer-of-split related with YRPW motif protein 2\",\"id\":\"Q9UBP5\"},{\"label\":\"Heart- and neural crest derivatives-expressed protein 1\",\"id\":\"O96004\"},{\"label\":\"Heart- and neural crest derivatives-expressed protein 2\",\"id\":\"P61296\"},{\"label\":\"Histone acetyltransferase KAT2A\",\"id\":\"Q92830\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Histone-lysine N-methyltransferase SMYD1\",\"id\":\"Q8NB12\"},{\"label\":\"Homeobox protein Nkx-2.5\",\"id\":\"P52952\"},{\"label\":\"Insulin gene enhancer protein ISL-1\",\"id\":\"P61371\"},{\"label\":\"LIM domain-binding protein 1\",\"id\":\"Q86U70\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Mesoderm posterior protein 1\",\"id\":\"Q9BRJ9\"},{\"label\":\"Mothers against decapentaplegic homolog 1\",\"id\":\"Q15797\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"Myocardin\",\"id\":\"Q8IZQ8\"},{\"label\":\"Myocyte-specific enhancer factor 2C\",\"id\":\"Q06413\"},{\"label\":\"Serum response factor\",\"id\":\"P11831\"},{\"label\":\"T-box transcription factor T\",\"id\":\"O15178\"},{\"label\":\"T-box transcription factor TBX1\",\"id\":\"O43435\"},{\"label\":\"T-box transcription factor TBX20\",\"id\":\"Q9UMR3\"},{\"label\":\"T-box transcription factor TBX5\",\"id\":\"Q99593\"},{\"label\":\"Transcription factor GATA-4\",\"id\":\"P43694\"},{\"label\":\"Transcription factor GATA-6\",\"id\":\"Q92908\"},{\"label\":\"WD repeat-containing protein 5\",\"id\":\"P61964\"}]", "uniprot_id": 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cytosolic FGFR1 fusion mutants", "protein_name": "[{\"label\":\"Breakpoint cluster region protein\",\"id\":\"P11274\"},{\"label\":\"Centrosomal protein 43\",\"id\":\"O95684\"},{\"label\":\"Cleavage and polyadenylation specificity factor subunit 6\",\"id\":\"Q16630\"},{\"label\":\"FGFR1 oncogene partner 2\",\"id\":\"Q9NVK5\"},{\"label\":\"GRB2-associated-binding protein 2\",\"id\":\"Q9UQC2\"},{\"label\":\"Homeobox protein cut-like 1\",\"id\":\"P39880\"},{\"label\":\"Leucine-rich repeat flightless-interacting protein 1\",\"id\":\"Q32MZ4\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Transcription intermediary factor 1-alpha\",\"id\":\"O15164\"},{\"label\":\"Unconventional myosin-XVIIIa\",\"id\":\"Q92614\"},{\"label\":\"Zinc finger MYM-type protein 2\",\"id\":\"Q9UBW7\"}]", "uniprot_id": "[\"O15164\",\"O95684\",\"P11274\",\"P27986\",\"P39880\",\"P40763\",\"P42224\",\"P42229\",\"P42336\",\"P51692\",\"Q16630\",\"Q32MZ4\",\"Q92614\",\"Q9NVK5\",\"Q9UBW7\",\"Q9UQC2\"]", "gene_symbol": "[\"APRF\",\"BCR\",\"BCR1\",\"CD245\",\"CEP43\",\"CFIM68\",\"CPSF6\",\"CUTL1\",\"CUX1\",\"D22S11\",\"FGFR1OP\",\"FGFR1OP2\",\"FIM\",\"FOP\",\"GAB2\",\"GCF2\",\"GRB1\",\"KIAA0216\",\"KIAA0571\",\"LRRFIP1\",\"MYO18A\",\"MYSPDZ\",\"PIK3CA\",\"PIK3R1\",\"RAMP\",\"RNF82\",\"STAT1\",\"STAT3\",\"STAT5\",\"STAT5A\",\"STAT5B\",\"TIAF1\",\"TIF1\",\"TIF1A\",\"TRIM24\",\"TRIP\",\"ZMYM2\",\"ZNF198\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interconversion of nucleotide di- and triphosphates", "protein_name": "[{\"label\":\"Adenylate kinase 2, mitochondrial\",\"id\":\"P54819\"},{\"label\":\"Adenylate kinase 4, mitochondrial\",\"id\":\"P27144\"},{\"label\":\"Adenylate kinase 7\",\"id\":\"Q96M32\"},{\"label\":\"Adenylate kinase 8\",\"id\":\"Q96MA6\"},{\"label\":\"Adenylate kinase 9\",\"id\":\"Q5TCS8\"},{\"label\":\"Adenylate kinase isoenzyme 1\",\"id\":\"P00568\"},{\"label\":\"Adenylate kinase isoenzyme 5\",\"id\":\"Q9Y6K8\"},{\"label\":\"Adenylate kinase isoenzyme 6\",\"id\":\"Q9Y3D8\"},{\"label\":\"CTP synthase 1\",\"id\":\"P17812\"},{\"label\":\"CTP synthase 2\",\"id\":\"Q9NRF8\"},{\"label\":\"Deoxycytidylate deaminase\",\"id\":\"P32321\"},{\"label\":\"Glutaredoxin-1\",\"id\":\"P35754\"},{\"label\":\"Guanylate kinase\",\"id\":\"Q16774\"},{\"label\":\"NAD(P)H pyrophosphatase NUDT13, mitochondrial\",\"id\":\"Q86X67\"},{\"label\":\"Nucleoside diphosphate kinase 3\",\"id\":\"Q13232\"},{\"label\":\"Nucleoside diphosphate kinase A\",\"id\":\"P15531\"},{\"label\":\"Nucleoside diphosphate kinase B\",\"id\":\"P22392\"},{\"label\":\"Nucleoside diphosphate kinase, mitochondrial\",\"id\":\"O00746\"},{\"label\":\"Putative nucleoside diphosphate kinase\",\"id\":\"O60361\"},{\"label\":\"Ribonucleoside-diphosphate reductase large subunit\",\"id\":\"P23921\"},{\"label\":\"Ribonucleoside-diphosphate reductase subunit M2 B\",\"id\":\"Q7LG56\"},{\"label\":\"Ribonucleoside-diphosphate reductase subunit M2\",\"id\":\"P31350\"},{\"label\":\"Thioredoxin reductase 1, cytoplasmic\",\"id\":\"Q16881\"},{\"label\":\"Thioredoxin\",\"id\":\"P10599\"},{\"label\":\"Thymidylate kinase\",\"id\":\"P23919\"},{\"label\":\"Thymidylate synthase\",\"id\":\"P04818\"},{\"label\":\"UMP-CMP kinase\",\"id\":\"P30085\"},{\"label\":\"dCTP pyrophosphatase 1\",\"id\":\"Q9H773\"}]", "uniprot_id": 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and CHDS", "protein_name": "[{\"label\":\"Agrin\",\"id\":\"O00468\"},{\"label\":\"Basement membrane-specific heparan sulfate proteoglycan core protein\",\"id\":\"P98160\"},{\"label\":\"Exostosin-1\",\"id\":\"Q16394\"},{\"label\":\"Exostosin-2\",\"id\":\"Q93063\"},{\"label\":\"Glypican-1\",\"id\":\"P35052\"},{\"label\":\"Glypican-2\",\"id\":\"Q8N158\"},{\"label\":\"Glypican-3\",\"id\":\"P51654\"},{\"label\":\"Glypican-4\",\"id\":\"O75487\"},{\"label\":\"Glypican-5\",\"id\":\"P78333\"},{\"label\":\"Glypican-6\",\"id\":\"Q9Y625\"},{\"label\":\"Syndecan-1\",\"id\":\"P18827\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Syndecan-3\",\"id\":\"O75056\"},{\"label\":\"Syndecan-4\",\"id\":\"P31431\"}]", "uniprot_id": "[\"O00468\",\"O75056\",\"O75487\",\"P18827\",\"P31431\",\"P34741\",\"P35052\",\"P51654\",\"P78333\",\"P98160\",\"Q16394\",\"Q8N158\",\"Q93063\",\"Q9Y625\"]", "gene_symbol": 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catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O15169\",\"P25054\",\"P30153\",\"P30154\",\"P35222\",\"P48729\",\"P49841\",\"P62714\",\"P67775\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\"]", "gene_symbol": "[\"AMER1\",\"APC\",\"AXIN\",\"AXIN1\",\"CSNK1A1\",\"CTNNB\",\"CTNNB1\",\"DP2.5\",\"FAM123B\",\"GSK3B\",\"KIAA0044\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"WTX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Polymerase I Transcription Termination", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Caveolae-associated protein 1\",\"id\":\"Q6NZI2\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA-directed RNA polymerase I subunit 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transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Nucleolar transcription factor 1\",\"id\":\"P17480\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit A\",\"id\":\"Q15573\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit B\",\"id\":\"Q53T94\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit C\",\"id\":\"Q15572\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit D\",\"id\":\"Q9H5J8\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription termination factor 1\",\"id\":\"Q15361\"}]", "uniprot_id": "[\"O15160\",\"O15446\",\"O95602\",\"P0DPB5\",\"P17480\",\"P18074\",\"P19388\",\"P19447\",\"P20226\",\"P32780\",\"P50613\",\"P51946\",\"P51948\",\"P52434\",\"P53803\",\"P61218\",\"P62875\",\"Q13888\",\"Q13889\",\"Q15361\",\"Q15572\",\"Q15573\",\"Q3B726\",\"Q53T94\",\"Q6NZI2\",\"Q6ZYL4\",\"Q92759\",\"Q9GZS1\",\"Q9H5J8\",\"Q9H9Y6\",\"Q9P1U0\"]", "gene_symbol": 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"[{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"FAS-associated death domain protein\",\"id\":\"Q13158\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"Tumor necrosis factor receptor type 1-associated DEATH domain protein\",\"id\":\"Q15628\"}]", "uniprot_id": "[\"Q12933\",\"Q13158\",\"Q13546\",\"Q14790\",\"Q15628\"]", "gene_symbol": "[\"CASP8\",\"FADD\",\"MCH5\",\"MORT1\",\"RIP\",\"RIP1\",\"RIPK1\",\"TRADD\",\"TRAF2\",\"TRAP3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of MITF-M dependent genes involved in invasion", "protein_name": "[{\"label\":\"Carcinoembryonic antigen-related cell adhesion molecule 1\",\"id\":\"P13688\"},{\"label\":\"GMP reductase 1\",\"id\":\"P36959\"},{\"label\":\"Protein diaphanous homolog 1\",\"id\":\"O60610\"}]", "uniprot_id": "[\"O60610\",\"P13688\",\"P36959\"]", "gene_symbol": "[\"BGP\",\"BGP1\",\"CEACAM1\",\"DIAP1\",\"DIAPH1\",\"GMPR\",\"GMPR1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TRAIL signaling", "protein_name": "[{\"label\":\"CASP8 and FADD-like apoptosis regulator\",\"id\":\"O15519\"},{\"label\":\"Caspase-10\",\"id\":\"Q92851\"},{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"FAS-associated death domain protein\",\"id\":\"Q13158\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 10\",\"id\":\"P50591\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10A\",\"id\":\"O00220\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10B\",\"id\":\"O14763\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10D\",\"id\":\"Q9UBN6\"}]", "uniprot_id": "[\"O00220\",\"O14763\",\"O15519\",\"P50591\",\"Q13158\",\"Q14790\",\"Q92851\",\"Q9UBN6\"]", "gene_symbol": 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4\",\"id\":\"P54764\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Mesoderm posterior protein 2\",\"id\":\"Q0VG99\"},{\"label\":\"Mesogenin-1\",\"id\":\"A6NI15\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta 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by phosphorylation", "protein_name": "[{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-2\",\"id\":\"P54646\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-1\",\"id\":\"Q9Y478\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-2\",\"id\":\"O43741\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-1\",\"id\":\"P54619\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-2\",\"id\":\"Q9UGJ0\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-3\",\"id\":\"Q9UGI9\"},{\"label\":\"Mitogen-activated protein kinase 11\",\"id\":\"Q15759\"},{\"label\":\"Mitogen-activated protein kinase 12\",\"id\":\"P53778\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha\",\"id\":\"Q9UBK2\"}]", "uniprot_id": "[\"O43741\",\"P53778\",\"P54619\",\"P54646\",\"Q15759\",\"Q16539\",\"Q9UBK2\",\"Q9UGI9\",\"Q9UGJ0\",\"Q9Y478\"]", "gene_symbol": 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Src\",\"id\":\"P12931\"}]", "uniprot_id": "[\"P12931\",\"P20783\",\"P27986\",\"P35568\",\"P42336\",\"Q16288\"]", "gene_symbol": "[\"GRB1\",\"IRS1\",\"NTF3\",\"NTRK3\",\"PIK3CA\",\"PIK3R1\",\"SRC\",\"SRC1\",\"TRKC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "protein_name": "[{\"label\":\"Coagulation factor VIII\",\"id\":\"P00451\"},{\"label\":\"Fructosamine-3-kinase\",\"id\":\"Q9H479\"},{\"label\":\"Ketosamine-3-kinase\",\"id\":\"Q9HA64\"},{\"label\":\"Protein-S-isoprenylcysteine O-methyltransferase\",\"id\":\"O60725\"},{\"label\":\"Protein-tyrosine sulfotransferase 1\",\"id\":\"O60507\"},{\"label\":\"Protein-tyrosine sulfotransferase 2\",\"id\":\"O60704\"}]", "uniprot_id": "[\"O60507\",\"O60704\",\"O60725\",\"P00451\",\"Q9H479\",\"Q9HA64\"]", "gene_symbol": "[\"F8\",\"F8C\",\"FN3K\",\"FN3KRP\",\"ICMT\",\"PCCMT\",\"TPST1\",\"TPST2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective OPLAH causes OPLAHD", "protein_name": "[{\"label\":\"5-oxoprolinase\",\"id\":\"O14841\"}]", "uniprot_id": "[\"O14841\"]", "gene_symbol": "[\"OPLAH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Polymerase I Transcription Initiation", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 3\",\"id\":\"Q12873\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 4\",\"id\":\"Q14839\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA excision repair protein ERCC-6\",\"id\":\"Q03468\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA12\",\"id\":\"Q9P1U0\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA1\",\"id\":\"O95602\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA2\",\"id\":\"Q9H9Y6\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA34\",\"id\":\"O15446\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA43\",\"id\":\"Q3B726\"},{\"label\":\"DNA-directed RNA polymerase I subunit RPA49\",\"id\":\"Q9GZS1\"},{\"label\":\"DNA-directed RNA polymerases I and III subunit RPAC1\",\"id\":\"O15160\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Histone acetyltransferase KAT2A\",\"id\":\"Q92830\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone deacetylase 2\",\"id\":\"Q92769\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Histone-binding protein RBBP7\",\"id\":\"Q16576\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT2\",\"id\":\"Q96KQ7\"},{\"label\":\"Metastasis-associated protein MTA1\",\"id\":\"Q13330\"},{\"label\":\"Metastasis-associated protein MTA2\",\"id\":\"O94776\"},{\"label\":\"Metastasis-associated protein MTA3\",\"id\":\"Q9BTC8\"},{\"label\":\"Methyl-CpG-binding domain protein 3\",\"id\":\"O95983\"},{\"label\":\"Nucleolar transcription factor 1\",\"id\":\"P17480\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"},{\"label\":\"RNA polymerase I-specific transcription initiation factor RRN3\",\"id\":\"Q9NYV6\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit A\",\"id\":\"Q15573\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit B\",\"id\":\"Q53T94\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit C\",\"id\":\"Q15572\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit D\",\"id\":\"Q9H5J8\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription termination factor 1\",\"id\":\"Q15361\"},{\"label\":\"Transcriptional repressor p66-alpha\",\"id\":\"Q86YP4\"},{\"label\":\"Transcriptional repressor p66-beta\",\"id\":\"Q8WXI9\"}]", "uniprot_id": 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CBL\",\"id\":\"P22681\"},{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 22\",\"id\":\"Q9HCT0\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 3\",\"id\":\"P11487\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 7\",\"id\":\"P21781\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O15520\",\"O43320\",\"O76093\",\"P05230\",\"P08620\",\"P09038\",\"P0CG47\",\"P0CG48\",\"P10767\",\"P11487\",\"P21781\",\"P22681\",\"P27361\",\"P28482\",\"P31371\",\"P62979\",\"P62987\",\"Q06124\",\"Q8WU20\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", "gene_symbol": 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beta\",\"id\":\"O60566\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2A\",\"id\":\"Q13257\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Serine/threonine-protein kinase Nek2\",\"id\":\"P51955\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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proliferation", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"3-phosphoinositide-dependent protein kinase 1\",\"id\":\"O15530\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1\",\"id\":\"Q14643\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2\",\"id\":\"Q14571\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3\",\"id\":\"Q14573\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Protein kinase C beta type\",\"id\":\"P05771\"},{\"label\":\"Protein kinase C delta type\",\"id\":\"Q05655\"},{\"label\":\"Protein kinase C zeta type\",\"id\":\"Q05513\"},{\"label\":\"Ras GTPase-activating protein 1\",\"id\":\"P20936\"},{\"label\":\"S-adenosylhomocysteine hydrolase-like protein 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2\",\"id\":\"Q496F6\"},{\"label\":\"CMRF35-like molecule 7\",\"id\":\"A8K4G0\"},{\"label\":\"HLA class I histocompatibility antigen, B alpha chain\",\"id\":\"P01889\"},{\"label\":\"HLA class I histocompatibility antigen, C alpha chain\",\"id\":\"P10321\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain E\",\"id\":\"P13747\"},{\"label\":\"Killer cell immunoglobulin-like receptor 2DS2\",\"id\":\"P43631\"},{\"label\":\"Killer cell immunoglobulin-like receptor 2DS4\",\"id\":\"P43632\"},{\"label\":\"Killer cell immunoglobulin-like receptor 2DS5\",\"id\":\"Q14953\"},{\"label\":\"Killer cell immunoglobulin-like receptor 3DS1\",\"id\":\"Q14943\"},{\"label\":\"NKG2-C type II integral membrane protein\",\"id\":\"P26717\"},{\"label\":\"NKG2-D type II integral membrane protein\",\"id\":\"P26718\"},{\"label\":\"Natural cytotoxicity triggering receptor 2\",\"id\":\"O95944\"},{\"label\":\"Natural killer cells antigen CD94\",\"id\":\"Q13241\"},{\"label\":\"Sialic acid-binding Ig-like lectin 14\",\"id\":\"Q08ET2\"},{\"label\":\"Sialic acid-binding Ig-like lectin 15\",\"id\":\"Q6ZMC9\"},{\"label\":\"Sialic acid-binding Ig-like lectin 16\",\"id\":\"A6NMB1\"},{\"label\":\"Signal-regulatory protein beta-1\",\"id\":\"O00241\"},{\"label\":\"TYRO protein tyrosine kinase-binding protein\",\"id\":\"O43914\"},{\"label\":\"Triggering receptor expressed on myeloid cells 1\",\"id\":\"Q9NP99\"},{\"label\":\"Triggering receptor expressed on myeloid cells 2\",\"id\":\"Q9NZC2\"}]", "uniprot_id": "[\"A6NMB1\",\"A8K4G0\",\"O00241\",\"O43914\",\"O95944\",\"P01889\",\"P10321\",\"P13747\",\"P26717\",\"P26718\",\"P43631\",\"P43632\",\"P61769\",\"Q08ET2\",\"Q13241\",\"Q14943\",\"Q14953\",\"Q496F6\",\"Q6ZMC9\",\"Q9NP99\",\"Q9NY25\",\"Q9NZC2\"]", "gene_symbol": 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2\",\"id\":\"Q92769\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Hypoxia-inducible factor 1-alpha\",\"id\":\"Q16665\"},{\"label\":\"PR domain zinc finger protein 1\",\"id\":\"O75626\"},{\"label\":\"Paired amphipathic helix protein Sin3a\",\"id\":\"Q96ST3\"},{\"label\":\"Programmed cell death 1 ligand 1\",\"id\":\"Q9NZQ7\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"}]", "uniprot_id": "[\"O15379\",\"O75626\",\"P26358\",\"P31785\",\"P40763\",\"Q09472\",\"Q13547\",\"Q16665\",\"Q92769\",\"Q96ST3\",\"Q9NZQ7\"]", "gene_symbol": "[\"AIM\",\"APRF\",\"B7H1\",\"BHLHE78\",\"BLIMP1\",\"CD274\",\"CXXC9\",\"DNMT\",\"DNMT1\",\"EP300\",\"HDAC1\",\"HDAC2\",\"HDAC3\",\"HIF1A\",\"IL2RG\",\"MOP1\",\"P300\",\"PASD8\",\"PDCD1L1\",\"PDCD1LG1\",\"PDL1\",\"PRDM1\",\"RPD3L1\",\"SIN3A\",\"STAT3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Organic anion transport", "protein_name": "[{\"label\":\"Organic anion transporter 3\",\"id\":\"Q8TCC7\"},{\"label\":\"Solute carrier family 22 member 11\",\"id\":\"Q9NSA0\"},{\"label\":\"Solute carrier family 22 member 12\",\"id\":\"Q96S37\"},{\"label\":\"Solute carrier family 22 member 6\",\"id\":\"Q4U2R8\"},{\"label\":\"Solute carrier family 22 member 7\",\"id\":\"Q9Y694\"}]", "uniprot_id": "[\"Q4U2R8\",\"Q8TCC7\",\"Q96S37\",\"Q9NSA0\",\"Q9Y694\"]", "gene_symbol": "[\"NLT\",\"OAT1\",\"OAT2\",\"OAT3\",\"OAT4\",\"OATL4\",\"PAHT\",\"SLC22A11\",\"SLC22A12\",\"SLC22A6\",\"SLC22A7\",\"SLC22A8\",\"URAT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-1 signaling", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 6\",\"id\":\"P52564\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 1\",\"id\":\"Q96FA3\"},{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 2\",\"id\":\"Q9HAT8\"},{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 3\",\"id\":\"Q8N2H9\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Interleukin-1 alpha\",\"id\":\"P01583\"},{\"label\":\"Interleukin-1 beta\",\"id\":\"P01584\"},{\"label\":\"Interleukin-1 receptor antagonist protein\",\"id\":\"P18510\"},{\"label\":\"Interleukin-1 receptor type 1\",\"id\":\"P14778\"},{\"label\":\"Interleukin-1 receptor type 2\",\"id\":\"P27930\"},{\"label\":\"Interleukin-1 receptor-associated kinase 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7\",\"id\":\"P36402\"},{\"label\":\"Transducin-like enhancer protein 1\",\"id\":\"Q04724\"},{\"label\":\"Transducin-like enhancer protein 2\",\"id\":\"Q04725\"},{\"label\":\"Transducin-like enhancer protein 3\",\"id\":\"Q04726\"},{\"label\":\"Transducin-like enhancer protein 4\",\"id\":\"Q04727\"}]", "uniprot_id": "[\"P36402\",\"P56545\",\"Q04724\",\"Q04725\",\"Q04726\",\"Q04727\",\"Q08117\",\"Q13363\",\"Q13547\",\"Q9HCS4\",\"Q9NQB0\",\"Q9UJU2\"]", "gene_symbol": "[\"AES\",\"CTBP\",\"CTBP1\",\"CTBP2\",\"GRG\",\"GRG4\",\"GRG5\",\"HDAC1\",\"KIAA1261\",\"KIAA1547\",\"LEF1\",\"RPD3L1\",\"TCF1\",\"TCF3\",\"TCF4\",\"TCF7\",\"TCF7L1\",\"TCF7L2\",\"TLE1\",\"TLE2\",\"TLE3\",\"TLE4\",\"TLE5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SIRT1 negatively regulates rRNA expression", "protein_name": "[{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 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2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H3.3\",\"id\":\"P84243\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone-lysine N-methyltransferase SUV39H1\",\"id\":\"O43463\"},{\"label\":\"NAD-dependent protein deacetylase sirtuin-1\",\"id\":\"Q96EB6\"},{\"label\":\"Ribosomal RNA-processing protein 8\",\"id\":\"O43159\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit A\",\"id\":\"Q15573\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit B\",\"id\":\"Q53T94\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit C\",\"id\":\"Q15572\"},{\"label\":\"TATA box-binding protein-associated factor RNA polymerase I subunit D\",\"id\":\"Q9H5J8\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"}]", "uniprot_id": "[\"O43159\",\"O43463\",\"O60814\",\"P04908\",\"P06899\",\"P0C5Y9\",\"P16104\",\"P20226\",\"P20671\",\"P23527\",\"P33778\",\"P57053\",\"P58876\",\"P62805\",\"P62807\",\"P68431\",\"P84243\",\"Q15572\",\"Q15573\",\"Q16777\",\"Q16778\",\"Q53T94\",\"Q6FI13\",\"Q71DI3\",\"Q71UI9\",\"Q8N257\",\"Q93077\",\"Q93079\",\"Q96A08\",\"Q96EB6\",\"Q99877\",\"Q99878\",\"Q99879\",\"Q99880\",\"Q9BTM1\",\"Q9H5J8\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "PTEN Loss of Function in Cancer", "protein_name": "[{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN\",\"id\":\"P60484\"}]", "uniprot_id": "[\"P60484\"]", "gene_symbol": "[\"MMAC1\",\"PTEN\",\"TEP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FLT3 Signaling", "protein_name": "[{\"label\":\"Bcl-2-like protein 11\",\"id\":\"O43521\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"Fms-related tyrosine kinase 3 ligand\",\"id\":\"P49771\"},{\"label\":\"Forkhead box protein O3\",\"id\":\"O43524\"},{\"label\":\"GRB2-associated-binding protein 2\",\"id\":\"Q9UQC2\"},{\"label\":\"GRB2-related adapter protein 2\",\"id\":\"O75791\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Growth factor receptor-bound protein 10\",\"id\":\"Q13322\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O43521\",\"O43524\",\"O75791\",\"P01111\",\"P01112\",\"P27986\",\"P31749\",\"P31751\",\"P36888\",\"P42336\",\"P46527\",\"P49771\",\"Q06124\",\"Q07889\",\"Q13322\",\"Q9UQC2\",\"Q9Y243\"]", "gene_symbol": "[\"AKT1\",\"AKT2\",\"AKT3\",\"BCL2L11\",\"BIM\",\"CD135\",\"CDKN1B\",\"FKHRL1\",\"FLK2\",\"FLT3\",\"FLT3LG\",\"FOXO3\",\"FOXO3A\",\"GAB2\",\"GADS\",\"GRAP2\",\"GRB1\",\"GRB10\",\"GRB2L\",\"GRBIR\",\"GRID\",\"HRAS\",\"HRAS1\",\"KIAA0207\",\"KIAA0571\",\"KIP1\",\"NRAS\",\"PIK3CA\",\"PIK3R1\",\"PKB\",\"PKBG\",\"PTP2C\",\"PTPN11\",\"RAC\",\"SHPTP2\",\"SOS1\",\"STK1\",\"p27\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of PTEN mRNA translation", "protein_name": "[{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN\",\"id\":\"P60484\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"}]", "uniprot_id": "[\"P60484\",\"Q8NDV7\",\"Q9H9G7\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9UPQ9\"]", "gene_symbol": "[\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"CAGH26\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"KIAA1631\",\"MMAC1\",\"MOV10\",\"PTEN\",\"TEP1\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "mRNA Capping", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Transcription elongation factor SPT5\",\"id\":\"O00267\"},{\"label\":\"mRNA cap guanine-N7 methyltransferase\",\"id\":\"O43148\"},{\"label\":\"mRNA-capping enzyme\",\"id\":\"O60942\"}]", "uniprot_id": "[\"O00267\",\"O15514\",\"O43148\",\"O60942\",\"P13984\",\"P18074\",\"P19387\",\"P19388\",\"P19447\",\"P24928\",\"P30876\",\"P32780\",\"P35269\",\"P36954\",\"P50613\",\"P51946\",\"P51948\",\"P52298\",\"P52434\",\"P52435\",\"P53803\",\"P61218\",\"P62487\",\"P62875\",\"Q09161\",\"Q13888\",\"Q13889\",\"Q6ZYL4\",\"Q92759\"]", "gene_symbol": "[\"BTF2\",\"BTF2P44\",\"C6orf175\",\"CAK\",\"CAK1\",\"CAP1A\",\"CAP35\",\"CBP20\",\"CBP80\",\"CCNH\",\"CDK7\",\"CDKN7\",\"ERCC2\",\"ERCC3\",\"GTF2F1\",\"GTF2F2\",\"GTF2H1\",\"GTF2H2\",\"GTF2H3\",\"GTF2H4\",\"GTF2H5\",\"KIAA0398\",\"MAT1\",\"MNAT1\",\"MO15\",\"NCBP\",\"NCBP1\",\"NCBP2\",\"POLR2\",\"POLR2A\",\"POLR2B\",\"POLR2C\",\"POLR2D\",\"POLR2E\",\"POLR2F\",\"POLR2G\",\"POLR2H\",\"POLR2I\",\"POLR2J\",\"POLR2J1\",\"POLR2K\",\"POLR2L\",\"POLRF\",\"RAP30\",\"RAP74\",\"RNF66\",\"RNGTT\",\"RNMT\",\"RPB7\",\"SPT5\",\"SPT5H\",\"STK1\",\"SUPT5H\",\"TTDA\",\"XPB\",\"XPBC\",\"XPD\",\"XPDC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Pre-NOTCH Processing in the Endoplasmic Reticulum", "protein_name": "[{\"label\":\"GDP-fucose protein O-fucosyltransferase 1\",\"id\":\"Q9H488\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Neurogenic locus notch homolog protein 2\",\"id\":\"Q04721\"},{\"label\":\"Neurogenic locus notch homolog protein 3\",\"id\":\"Q9UM47\"},{\"label\":\"Neurogenic locus notch homolog protein 4\",\"id\":\"Q99466\"},{\"label\":\"Protein O-glucosyltransferase 1\",\"id\":\"Q8NBL1\"}]", "uniprot_id": "[\"P46531\",\"Q04721\",\"Q8NBL1\",\"Q99466\",\"Q9H488\",\"Q9UM47\"]", "gene_symbol": "[\"C3orf9\",\"CLP46\",\"FUT12\",\"INT3\",\"KIAA0180\",\"KTELC1\",\"MDSRP\",\"NOTCH1\",\"NOTCH2\",\"NOTCH3\",\"NOTCH4\",\"POFUT1\",\"POGLUT1\",\"TAN1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "protein_name": "[{\"label\":\"High affinity choline transporter 1\",\"id\":\"Q9GZV3\"}]", "uniprot_id": "[\"Q9GZV3\"]", "gene_symbol": "[\"CHT1\",\"SLC5A7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SLBP independent Processing of Histone Pre-mRNAs", "protein_name": "[{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Small nuclear ribonucleoprotein E\",\"id\":\"P62304\"},{\"label\":\"Small nuclear ribonucleoprotein F\",\"id\":\"P62306\"},{\"label\":\"Small nuclear ribonucleoprotein G\",\"id\":\"P62308\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D3\",\"id\":\"P62318\"},{\"label\":\"Small nuclear ribonucleoprotein-associated proteins B and B'\",\"id\":\"P14678\"},{\"label\":\"U7 snRNA-associated Sm-like protein LSm10\",\"id\":\"Q969L4\"},{\"label\":\"U7 snRNA-associated Sm-like protein LSm11\",\"id\":\"P83369\"},{\"label\":\"Zinc finger protein 473\",\"id\":\"Q8WTR7\"}]", "uniprot_id": "[\"P14678\",\"P52298\",\"P62304\",\"P62306\",\"P62308\",\"P62318\",\"P83369\",\"Q09161\",\"Q8WTR7\",\"Q969L4\"]", "gene_symbol": "[\"CBP20\",\"CBP80\",\"COD\",\"KIAA1141\",\"LSM10\",\"LSM11\",\"NCBP\",\"NCBP1\",\"NCBP2\",\"PBSCF\",\"PBSCG\",\"SNRPB\",\"SNRPB1\",\"SNRPD3\",\"SNRPE\",\"SNRPF\",\"SNRPG\",\"ZFP100\",\"ZNF473\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of PLK1 Activity at G2/M Transition", "protein_name": "[{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"14-3-3 protein gamma\",\"id\":\"P61981\"},{\"label\":\"A-kinase anchor protein 9\",\"id\":\"Q99996\"},{\"label\":\"Alpha-centractin\",\"id\":\"P61163\"},{\"label\":\"Aurora kinase A\",\"id\":\"O14965\"},{\"label\":\"CDK5 regulatory subunit-associated protein 2\",\"id\":\"Q96SN8\"},{\"label\":\"CLIP-associating protein 1\",\"id\":\"Q7Z460\"},{\"label\":\"Casein kinase I isoform delta\",\"id\":\"P48730\"},{\"label\":\"Casein kinase I isoform epsilon\",\"id\":\"P49674\"},{\"label\":\"Centrin-2\",\"id\":\"P41208\"},{\"label\":\"Centriolar coiled-coil protein of 110 kDa\",\"id\":\"O43303\"},{\"label\":\"Centriole and centriolar satellite protein OFD1\",\"id\":\"O75665\"},{\"label\":\"Centriolin\",\"id\":\"Q7Z7A1\"},{\"label\":\"Centromere protein J\",\"id\":\"Q9HC77\"},{\"label\":\"Centrosomal protein 43\",\"id\":\"O95684\"},{\"label\":\"Centrosomal protein of 131 kDa\",\"id\":\"Q9UPN4\"},{\"label\":\"Centrosomal protein of 135 kDa\",\"id\":\"Q66GS9\"},{\"label\":\"Centrosomal protein of 152 kDa\",\"id\":\"O94986\"},{\"label\":\"Centrosomal protein of 164 kDa\",\"id\":\"Q9UPV0\"},{\"label\":\"Centrosomal protein of 192 kDa\",\"id\":\"Q8TEP8\"},{\"label\":\"Centrosomal protein of 290 kDa\",\"id\":\"O15078\"},{\"label\":\"Centrosomal protein of 41 kDa\",\"id\":\"Q9BYV8\"},{\"label\":\"Centrosomal protein of 57 kDa\",\"id\":\"Q86XR8\"},{\"label\":\"Centrosomal protein of 63 kDa\",\"id\":\"Q96MT8\"},{\"label\":\"Centrosomal protein of 70 kDa\",\"id\":\"Q8NHQ1\"},{\"label\":\"Centrosomal protein of 72 kDa\",\"id\":\"Q9P209\"},{\"label\":\"Centrosomal protein of 76 kDa\",\"id\":\"Q8TAP6\"},{\"label\":\"Centrosomal protein of 78 kDa\",\"id\":\"Q5JTW2\"},{\"label\":\"Centrosome-associated protein ALMS1\",\"id\":\"Q8TCU4\"},{\"label\":\"Centrosome-associated protein CEP250\",\"id\":\"Q9BV73\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoskeleton-associated protein 5\",\"id\":\"Q14008\"},{\"label\":\"Dynactin subunit 2\",\"id\":\"Q13561\"},{\"label\":\"Dynactin subunit 3\",\"id\":\"O75935\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"F-box/WD repeat-containing protein 11\",\"id\":\"Q9UKB1\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"G2/mitotic-specific cyclin-B2\",\"id\":\"O95067\"},{\"label\":\"HAUS augmin-like complex subunit 1\",\"id\":\"Q96CS2\"},{\"label\":\"HAUS augmin-like complex subunit 2\",\"id\":\"Q9NVX0\"},{\"label\":\"HAUS augmin-like complex subunit 3\",\"id\":\"Q68CZ6\"},{\"label\":\"HAUS augmin-like complex subunit 4\",\"id\":\"Q9H6D7\"},{\"label\":\"HAUS augmin-like complex subunit 5\",\"id\":\"O94927\"},{\"label\":\"HAUS augmin-like complex subunit 6\",\"id\":\"Q7Z4H7\"},{\"label\":\"HAUS augmin-like complex subunit 7\",\"id\":\"Q99871\"},{\"label\":\"HAUS augmin-like complex subunit 8\",\"id\":\"Q9BT25\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"LIM domain-containing protein ajuba\",\"id\":\"Q96IF1\"},{\"label\":\"Microtubule nucleation factor SSNA1\",\"id\":\"O43805\"},{\"label\":\"Microtubule-associated protein RP/EB family member 1\",\"id\":\"Q15691\"},{\"label\":\"Ninein-like protein\",\"id\":\"Q9Y2I6\"},{\"label\":\"Nuclear distribution protein nudE homolog 1\",\"id\":\"Q9NXR1\"},{\"label\":\"Optineurin\",\"id\":\"Q96CV9\"},{\"label\":\"Outer dense fiber protein 2\",\"id\":\"Q5BJF6\"},{\"label\":\"Pericentrin\",\"id\":\"O95613\"},{\"label\":\"Pericentriolar material 1 protein\",\"id\":\"Q15154\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit beta\",\"id\":\"P43034\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein NEDD1\",\"id\":\"Q8NHV4\"},{\"label\":\"Protein SFI1 homolog\",\"id\":\"A8K8P3\"},{\"label\":\"Protein aurora borealis\",\"id\":\"Q6PGQ7\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 12A\",\"id\":\"O14974\"},{\"label\":\"Ras-related protein Rab-8A\",\"id\":\"P61006\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"Serine/threonine-protein kinase Nek2\",\"id\":\"P51955\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"},{\"label\":\"Serine/threonine-protein kinase 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"gtc_id": "[\"\"]" }, { "pathway_label": "Vitamin B5 (pantothenate) metabolism", "protein_name": "[{\"label\":\"4'-phosphopantetheine phosphatase\",\"id\":\"Q9NVE7\"},{\"label\":\"Autotaxin\",\"id\":\"Q13822\"},{\"label\":\"Ectonucleotide pyrophosphatase/phosphodiesterase family member 1\",\"id\":\"P22413\"},{\"label\":\"Ectonucleotide pyrophosphatase/phosphodiesterase family member 3\",\"id\":\"O14638\"},{\"label\":\"Fatty acid synthase\",\"id\":\"P49327\"},{\"label\":\"L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase\",\"id\":\"Q9NRN7\"},{\"label\":\"Mitochondrial coenzyme A diphosphatase NUDT8\",\"id\":\"Q8WV74\"},{\"label\":\"Mitochondrial coenzyme A transporter SLC25A42\",\"id\":\"Q86VD7\"},{\"label\":\"PDZ domain-containing protein 11\",\"id\":\"Q5EBL8\"},{\"label\":\"Pantetheinase\",\"id\":\"O95497\"},{\"label\":\"Pantetheine hydrolase VNN2\",\"id\":\"O95498\"},{\"label\":\"Sodium-dependent multivitamin transporter\",\"id\":\"Q9Y289\"},{\"label\":\"Solute carrier family 25 member 16\",\"id\":\"P16260\"}]", "uniprot_id": "[\"O14638\",\"O95497\",\"O95498\",\"P16260\",\"P22413\",\"P49327\",\"Q13822\",\"Q5EBL8\",\"Q86VD7\",\"Q8WV74\",\"Q9NRN7\",\"Q9NVE7\",\"Q9Y289\"]", "gene_symbol": "[\"AASDHPPT\",\"AIPP1\",\"ATX\",\"ENPP1\",\"ENPP2\",\"ENPP3\",\"FAS\",\"FASN\",\"GDA\",\"M6S1\",\"NPPS\",\"NUDT8\",\"PANK4\",\"PC1\",\"PDNP1\",\"PDNP2\",\"PDNP3\",\"PDZD11\",\"PDZK11\",\"PISP\",\"SLC25A16\",\"SLC25A42\",\"SLC5A6\",\"SMVT\",\"VNN1\",\"VNN2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein", "protein_name": "[{\"label\":\"Alpha-1,2-mannosyltransferase ALG9\",\"id\":\"Q9H6U8\"},{\"label\":\"Alpha-1,3/1,6-mannosyltransferase ALG2\",\"id\":\"Q9H553\"},{\"label\":\"Chitobiosyldiphosphodolichol beta-mannosyltransferase\",\"id\":\"Q9BT22\"},{\"label\":\"Dol-P-Glc\",\"id\":\"Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase:Q5BKT4\"},{\"label\":\"Dol-P-Glc\",\"id\":\"Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase:Q5I7T1\"},{\"label\":\"Dol-P-Man\",\"id\":\"Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase:Q92685\"},{\"label\":\"Dol-P-Man\",\"id\":\"Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase:Q9BV10\"},{\"label\":\"Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase\",\"id\":\"Q9BVK2\"},{\"label\":\"Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase\",\"id\":\"Q9Y672\"},{\"label\":\"GDP-Man\",\"id\":\"Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase:Q2TAA5\"},{\"label\":\"Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1\",\"id\":\"Q96AA3\"},{\"label\":\"Mannose-P-dolichol utilization defect 1 protein\",\"id\":\"O75352\"},{\"label\":\"UDP-N-acetylglucosamine transferase subunit ALG13\",\"id\":\"Q9NP73\"},{\"label\":\"UDP-N-acetylglucosamine transferase subunit ALG14\",\"id\":\"Q96F25\"},{\"label\":\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase\",\"id\":\"Q9H3H5\"}]", "uniprot_id": "[\"O75352\",\"Q2TAA5\",\"Q5BKT4\",\"Q5I7T1\",\"Q92685\",\"Q96AA3\",\"Q96F25\",\"Q9BT22\",\"Q9BV10\",\"Q9BVK2\",\"Q9H3H5\",\"Q9H553\",\"Q9H6U8\",\"Q9NP73\",\"Q9Y672\"]", "gene_symbol": "[\"ALG1\",\"ALG10\",\"ALG10A\",\"ALG10B\",\"ALG11\",\"ALG12\",\"ALG13\",\"ALG14\",\"ALG2\",\"ALG3\",\"ALG6\",\"ALG8\",\"ALG9\",\"CXorf45\",\"DIBD1\",\"DPAGT1\",\"DPAGT2\",\"GLT28D1\",\"GT8\",\"HMAT1\",\"HMT1\",\"KCR1\",\"MPDU1\",\"NOT\",\"NOT56L\",\"RFT1\"]", "gtc_id": "[\"G59406KS\"]" }, { "pathway_label": "TNFR1-induced NF-kappa-B signaling pathway", "protein_name": "[{\"label\":\"Baculoviral IAP repeat-containing protein 2\",\"id\":\"Q13490\"},{\"label\":\"Baculoviral IAP repeat-containing protein 3\",\"id\":\"Q13489\"},{\"label\":\"E3 ubiquitin-protein ligase RNF31\",\"id\":\"Q96EP0\"},{\"label\":\"E3 ubiquitin-protein ligase XIAP\",\"id\":\"P98170\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 7\",\"id\":\"O43318\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"OTU domain-containing protein 1\",\"id\":\"Q5VV17\"},{\"label\":\"OTU domain-containing protein 7B\",\"id\":\"Q6GQQ9\"},{\"label\":\"Optineurin\",\"id\":\"Q96CV9\"},{\"label\":\"RanBP-type and C3HC4-type zinc finger-containing protein 1\",\"id\":\"Q9BYM8\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"Sharpin\",\"id\":\"Q9H0F6\"},{\"label\":\"Small ribosomal subunit protein RACK1\",\"id\":\"P63244\"},{\"label\":\"Spermatogenesis-associated protein 2\",\"id\":\"Q9UM82\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 1\",\"id\":\"Q15750\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2\",\"id\":\"Q9NYJ8\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 3\",\"id\":\"Q8N5C8\"},{\"label\":\"TNF receptor-associated factor 1\",\"id\":\"Q13077\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"Tumor necrosis factor alpha-induced protein 3\",\"id\":\"P21580\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 1A\",\"id\":\"P19438\"},{\"label\":\"Tumor necrosis factor receptor type 1-associated DEATH domain protein\",\"id\":\"Q15628\"},{\"label\":\"Tumor necrosis factor\",\"id\":\"P01375\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 21\",\"id\":\"Q9UK80\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 2\",\"id\":\"O75604\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 4\",\"id\":\"Q13107\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase CYLD\",\"id\":\"Q9NQC7\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"O43318\",\"O75604\",\"P01375\",\"P19438\",\"P21580\",\"P63244\",\"P98170\",\"Q12933\",\"Q13077\",\"Q13107\",\"Q13489\",\"Q13490\",\"Q13546\",\"Q15628\",\"Q15750\",\"Q5VV17\",\"Q6GQQ9\",\"Q8N5C8\",\"Q96CV9\",\"Q96EP0\",\"Q9BYM8\",\"Q9H0F6\",\"Q9NQC7\",\"Q9NYJ8\",\"Q9UK80\",\"Q9UM82\",\"Q9Y6K9\"]", "gene_symbol": 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chain\",\"id\":\"P04839\"},{\"label\":\"Cytochrome b-245 light chain\",\"id\":\"P13498\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin beta-5\",\"id\":\"P18084\"},{\"label\":\"Neutrophil cytosol factor 1\",\"id\":\"P14598\"},{\"label\":\"Neutrophil cytosol factor 2\",\"id\":\"P19878\"},{\"label\":\"Neutrophil cytosol factor 4\",\"id\":\"Q15080\"},{\"label\":\"Platelet glycoprotein 4\",\"id\":\"P16671\"}]", "uniprot_id": "[\"P04839\",\"P06756\",\"P13498\",\"P14598\",\"P16671\",\"P18084\",\"P19878\",\"Q15080\"]", "gene_symbol": "[\"CD36\",\"CYBA\",\"CYBB\",\"GP3B\",\"GP4\",\"ITGAV\",\"ITGB5\",\"MSK8\",\"NCF1\",\"NCF2\",\"NCF4\",\"NOX2\",\"NOXA2\",\"NOXO2\",\"P67PHOX\",\"SH3PXD1A\",\"SH3PXD4\",\"VNRA\",\"VTNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NS1 Mediated Effects on Host Pathways", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Importin subunit alpha-1\",\"id\":\"P52292\"},{\"label\":\"Importin subunit alpha-3\",\"id\":\"O00629\"},{\"label\":\"Importin subunit alpha-4\",\"id\":\"O00505\"},{\"label\":\"Importin subunit alpha-5\",\"id\":\"P52294\"},{\"label\":\"Importin subunit alpha-6\",\"id\":\"O15131\"},{\"label\":\"Importin subunit alpha-8\",\"id\":\"A9QM74\"},{\"label\":\"Importin subunit beta-1\",\"id\":\"Q14974\"},{\"label\":\"Non-structural protein 1\",\"id\":\"P03496\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Ubiquitin-like protein ISG15\",\"id\":\"P05161\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": "[\"A8CG34\",\"A9QM74\",\"O00505\",\"O00629\",\"O15131\",\"O15504\",\"O75694\",\"P03496\",\"P05161\",\"P12270\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P52292\",\"P52294\",\"P55735\",\"P57740\",\"P78406\",\"Q12769\",\"Q14974\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8N1F7\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q96HA1\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9NRG9\",\"Q9UKX7\"]", "gene_symbol": "[\"AAAS\",\"ADRACALA\",\"C7orf14\",\"CAIN\",\"CAN\",\"CG1\",\"D3S1231E\",\"G1P2\",\"ISG15\",\"KIAA0023\",\"KIAA0095\",\"KIAA0169\",\"KIAA0197\",\"KIAA0225\",\"KIAA0618\",\"KIAA0791\",\"KIAA0906\",\"KPNA1\",\"KPNA2\",\"KPNA3\",\"KPNA4\",\"KPNA5\",\"KPNA7\",\"KPNB1\",\"MP44\",\"MRNP41\",\"NDC1\",\"NPAP60L\",\"NS\",\"NTF97\",\"NUP107\",\"NUP120\",\"NUP121\",\"NUP133\",\"NUP153\",\"NUP155\",\"NUP160\",\"NUP188\",\"NUP205\",\"NUP210\",\"NUP214\",\"NUP35\",\"NUP358\",\"NUP37\",\"NUP42\",\"NUP43\",\"NUP50\",\"NUP53\",\"NUP54\",\"NUP62\",\"NUP75\",\"NUP85\",\"NUP88\",\"NUP93\",\"NUPL2\",\"PCNT1\",\"POM121\",\"POM121A\",\"POM121C\",\"QIP1\",\"QIP2\",\"RAE1\",\"RANBP2\",\"RCH1\",\"RCH2\",\"SEC13\",\"SEC13A\",\"SEC13L1\",\"SEC13R\",\"SRP1\",\"TMEM48\",\"TPR\",\"UCRP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane", "protein_name": "[{\"label\":\"Gap junction alpha-1 protein\",\"id\":\"P17302\"}]", "uniprot_id": "[\"P17302\"]", "gene_symbol": "[\"GJA1\",\"GJAL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ADP signalling through P2Y purinoceptor 1", "protein_name": "[{\"label\":\"Cytosolic phospholipase A2\",\"id\":\"P47712\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(q) subunit alpha\",\"id\":\"P50148\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-11\",\"id\":\"P29992\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-14\",\"id\":\"O95837\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-15\",\"id\":\"P30679\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"P2Y purinoceptor 1\",\"id\":\"P47900\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O60262\",\"O95837\",\"P16520\",\"P29992\",\"P30679\",\"P47712\",\"P47900\",\"P50148\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63211\",\"P63215\",\"P63218\",\"Q16539\",\"Q9HAV0\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": 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"[\"P23526\",\"Q00266\",\"Q93088\",\"Q99707\",\"Q9H2M3\",\"Q9UBK8\"]", "gene_symbol": "[\"AHCY\",\"AMS1\",\"BHMT\",\"BHMT2\",\"MAT1A\",\"MATA1\",\"MTR\",\"MTRR\",\"SAHH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HCMV Early Events", "protein_name": "[{\"label\":\"65 kDa phosphoprotein\",\"id\":\"Q6SW59\"},{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Alkaline nuclease\",\"id\":\"F5HF49\"},{\"label\":\"Apoptosis inhibitor UL38\",\"id\":\"F5HG98\"},{\"label\":\"Capsid vertex component 1\",\"id\":\"Q6SW50\"},{\"label\":\"Capsid vertex component 2\",\"id\":\"Q6SW65\"},{\"label\":\"Chromobox protein homolog 1\",\"id\":\"P83916\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 1\",\"id\":\"O14576\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 2\",\"id\":\"O43237\"},{\"label\":\"Cytoplasmic envelopment protein 1\",\"id\":\"F5HA10\"},{\"label\":\"Cytoplasmic envelopment protein 2\",\"id\":\"F5HAC7\"},{\"label\":\"Cytoplasmic envelopment protein 3\",\"id\":\"F5HI87\"},{\"label\":\"DNA helicase/primase complex-associated protein\",\"id\":\"F5HIG1\"},{\"label\":\"DNA polymerase catalytic subunit\",\"id\":\"Q6SW77\"},{\"label\":\"DNA polymerase processivity factor\",\"id\":\"F5HC97\"},{\"label\":\"DNA replication helicase\",\"id\":\"F5HEN8\"},{\"label\":\"Death domain-associated protein 6\",\"id\":\"Q9UER7\"},{\"label\":\"Deoxyuridine 5'-triphosphate nucleotidohydrolase\",\"id\":\"Q6SW70\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"ETS domain-containing protein Elk-1\",\"id\":\"P19419\"},{\"label\":\"Early phosphoprotein p84\",\"id\":\"Q6SW37\"},{\"label\":\"Envelope glycoprotein B\",\"id\":\"F5HB53\"},{\"label\":\"Envelope glycoprotein H\",\"id\":\"Q6SW67\"},{\"label\":\"Envelope glycoprotein L\",\"id\":\"F5HCH8\"},{\"label\":\"Envelope glycoprotein M\",\"id\":\"Q6SW43\"},{\"label\":\"Envelope glycoprotein N\",\"id\":\"F5HHQ0\"},{\"label\":\"Envelope glycoprotein O\",\"id\":\"F5HGP1\"},{\"label\":\"Envelope glycoprotein UL130\",\"id\":\"F5HCP3\"},{\"label\":\"Envelope glycoprotein UL132\",\"id\":\"F5HGU6\"},{\"label\":\"Envelope glycoprotein UL4\",\"id\":\"Q6SWC6\"},{\"label\":\"Envelope glycoprotein US27\",\"id\":\"F5HDK1\"},{\"label\":\"Envelope protein US28\",\"id\":\"F5HF62\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"G protein pathway suppressor 2\",\"id\":\"Q13227\"},{\"label\":\"Histone H2A type 1-A\",\"id\":\"Q96QV6\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-H\",\"id\":\"Q96KK5\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 1\",\"id\":\"P0C0S8\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-B\",\"id\":\"Q8IUE6\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A type 3\",\"id\":\"Q7L7L0\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 2-F\",\"id\":\"Q5QNW6\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Histone-binding protein RBBP7\",\"id\":\"Q16576\"},{\"label\":\"Histone-lysine N-methyltransferase EZH2\",\"id\":\"Q15910\"},{\"label\":\"Immediate early protein IE1\",\"id\":\"F5HCM1\"},{\"label\":\"Inner tegument protein\",\"id\":\"Q6SW85\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Large tegument protein deneddylase\",\"id\":\"Q6SW84\"},{\"label\":\"Major DNA-binding protein\",\"id\":\"F5HDQ6\"},{\"label\":\"Major capsid protein\",\"id\":\"F5HGT1\"},{\"label\":\"Membrane glycoprotein RL11\",\"id\":\"Q6SWD1\"},{\"label\":\"Membrane glycoprotein US10\",\"id\":\"F5HFJ7\"},{\"label\":\"Membrane glycoprotein US11\",\"id\":\"Q6SVZ5\"},{\"label\":\"Membrane glycoprotein US3\",\"id\":\"F5HEU0\"},{\"label\":\"Membrane glycoprotein US8\",\"id\":\"F5HB52\"},{\"label\":\"Membrane glycoprotein US9\",\"id\":\"F5HC33\"},{\"label\":\"Membrane protein US13\",\"id\":\"F5H9I4\"},{\"label\":\"Membrane protein US14\",\"id\":\"F5HD92\"},{\"label\":\"Membrane protein US20\",\"id\":\"F5HGH8\"},{\"label\":\"Nuclear egress protein 1\",\"id\":\"F5HFZ4\"},{\"label\":\"Nuclear egress protein 2\",\"id\":\"Q6SW81\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Phosphoprotein 85\",\"id\":\"F5HGJ4\"},{\"label\":\"Polycomb protein EED\",\"id\":\"O75530\"},{\"label\":\"Polycomb protein SUZ12\",\"id\":\"Q15022\"},{\"label\":\"Portal protein\",\"id\":\"F5HBR4\"},{\"label\":\"Protein IRL10\",\"id\":\"F5HI32\"},{\"label\":\"Protein IRS1\",\"id\":\"Q6SW04\"},{\"label\":\"Protein PML\",\"id\":\"P29590\"},{\"label\":\"Protein RL1\",\"id\":\"Q6SWD5\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Protein TRS1\",\"id\":\"Q6SVX2\"},{\"label\":\"Protein UL11\",\"id\":\"Q6SWB9\"},{\"label\":\"Protein UL131A\",\"id\":\"F5HET4\"},{\"label\":\"Protein UL133\",\"id\":\"Q6SW10\"},{\"label\":\"Protein UL138\",\"id\":\"F5HGQ8\"},{\"label\":\"Protein UL16\",\"id\":\"F5HG68\"},{\"label\":\"Protein UL17\",\"id\":\"F5HHT4\"},{\"label\":\"Protein UL27\",\"id\":\"Q6SWA4\"},{\"label\":\"Protein UL5\",\"id\":\"Q6SWC5\"},{\"label\":\"Protein UL76\",\"id\":\"Q6SW66\"},{\"label\":\"Protein UL78\",\"id\":\"F5HET1\"},{\"label\":\"Protein UL79\",\"id\":\"Q6SW63\"},{\"label\":\"Protein UL84\",\"id\":\"F5HB40\"},{\"label\":\"Protein UL88\",\"id\":\"F5H9F9\"},{\"label\":\"Protein UL95\",\"id\":\"Q6SW48\"},{\"label\":\"Protein UL96\",\"id\":\"F5H8R6\"},{\"label\":\"Protein US16\",\"id\":\"Q6SVZ0\"},{\"label\":\"Protein US17\",\"id\":\"F5H9N9\"},{\"label\":\"Protein US23\",\"id\":\"F5HAZ3\"},{\"label\":\"Protein US26\",\"id\":\"F5H991\"},{\"label\":\"Protein US34\",\"id\":\"F5HEF3\"},{\"label\":\"Protein pp71\",\"id\":\"F5HBC6\"},{\"label\":\"Ribonucleoside-diphosphate reductase large subunit-like protein\",\"id\":\"Q6SW87\"},{\"label\":\"Serine/threonine protein kinase UL97\",\"id\":\"Q6SW46\"},{\"label\":\"Small capsomere-interacting protein\",\"id\":\"F5HEN7\"},{\"label\":\"Tegument protein UL23\",\"id\":\"F5HDM3\"},{\"label\":\"Tegument protein UL24\",\"id\":\"F5H9N4\"},{\"label\":\"Tegument protein UL26\",\"id\":\"F5HGG3\"},{\"label\":\"Tegument protein UL35\",\"id\":\"F5HE12\"},{\"label\":\"Tegument protein UL43\",\"id\":\"Q6SW89\"},{\"label\":\"Tegument protein UL51 homolog\",\"id\":\"F5HEA3\"},{\"label\":\"Tegument protein US22\",\"id\":\"F5HDC7\"},{\"label\":\"Tegument protein US24\",\"id\":\"F5H8S6\"},{\"label\":\"Tegument protein pp150\",\"id\":\"Q6SW99\"},{\"label\":\"Transcription intermediary factor 1-beta\",\"id\":\"Q13263\"},{\"label\":\"Transcriptional regulator UL34\",\"id\":\"F5HC16\"},{\"label\":\"Transmembrane protein US18\",\"id\":\"F5HE69\"},{\"label\":\"Transmembrane protein US19\",\"id\":\"F5HAR3\"},{\"label\":\"Triplex capsid protein 1\",\"id\":\"F5HA93\"},{\"label\":\"Triplex capsid protein 2\",\"id\":\"F5HIN9\"},{\"label\":\"UL37 immediate early glycoprotein\",\"id\":\"Q6SW94\"},{\"label\":\"Uncharacterized protein UL124\",\"id\":\"F5HHS3\"},{\"label\":\"Uncharacterized protein UL13\",\"id\":\"Q6SWB8\"},{\"label\":\"Uncharacterized protein UL21A\",\"id\":\"F5HH39\"},{\"label\":\"Uncharacterized protein US12\",\"id\":\"F5HE44\"},{\"label\":\"Uncharacterized protein US30\",\"id\":\"F5HB41\"},{\"label\":\"Uncharacterized protein US33A\",\"id\":\"F7V999\"},{\"label\":\"Uncharacterized protein US34A\",\"id\":\"Q6SVX3\"},{\"label\":\"Unique short US2 glycoprotein\",\"id\":\"F5HE05\"},{\"label\":\"Uracil-DNA glycosylase\",\"id\":\"F5HI85\"},{\"label\":\"Viral Fc-gamma receptor-like protein UL119\",\"id\":\"F5HC14\"},{\"label\":\"Viral inhibitor of caspase-8-induced apoptosis\",\"id\":\"F5HAY6\"},{\"label\":\"Viral interleukin-10 homolog\",\"id\":\"F5HC71\"},{\"label\":\"Viral transcription factor IE2\",\"id\":\"Q6SW29\"},{\"label\":\"mRNA export factor ICP27 homolog\",\"id\":\"Q6SW73\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": 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factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 22\",\"id\":\"Q9HCT0\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 3\",\"id\":\"P11487\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 7\",\"id\":\"P21781\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 2\",\"id\":\"P21802\"}]", "uniprot_id": "[\"O15520\",\"O43320\",\"O76093\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11487\",\"P21781\",\"P21802\",\"P31371\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", "gene_symbol": 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3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Collagen alpha-5(IV) chain\",\"id\":\"P29400\"},{\"label\":\"Cullin-2\",\"id\":\"Q13617\"},{\"label\":\"Dystroglycan 1\",\"id\":\"Q14118\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"Eukaryotic initiation factor 4A-III\",\"id\":\"P38919\"},{\"label\":\"Eukaryotic peptide chain release factor GTP-binding subunit ERF3A\",\"id\":\"P15170\"},{\"label\":\"Eukaryotic peptide chain release factor GTP-binding subunit ERF3B\",\"id\":\"Q8IYD1\"},{\"label\":\"Eukaryotic peptide chain release factor subunit 1\",\"id\":\"P62495\"},{\"label\":\"Eukaryotic translation initiation factor 4 gamma 1\",\"id\":\"Q04637\"},{\"label\":\"Homeobox protein Hox-A2\",\"id\":\"O43364\"},{\"label\":\"Insulin gene enhancer protein ISL-1\",\"id\":\"P61371\"},{\"label\":\"LIM domain-binding protein 1\",\"id\":\"Q86U70\"},{\"label\":\"LIM/homeobox protein Lhx2\",\"id\":\"P50458\"},{\"label\":\"LIM/homeobox protein Lhx3\",\"id\":\"Q9UBR4\"},{\"label\":\"LIM/homeobox protein Lhx4\",\"id\":\"Q969G2\"},{\"label\":\"LIM/homeobox protein Lhx9\",\"id\":\"Q9NQ69\"},{\"label\":\"Large ribosomal subunit protein P1\",\"id\":\"P05386\"},{\"label\":\"Large ribosomal subunit protein P2\",\"id\":\"P05387\"},{\"label\":\"Large ribosomal subunit protein eL13\",\"id\":\"P26373\"},{\"label\":\"Large ribosomal subunit protein eL14\",\"id\":\"P50914\"},{\"label\":\"Large ribosomal subunit protein eL15\",\"id\":\"P61313\"},{\"label\":\"Large ribosomal subunit protein eL18\",\"id\":\"Q07020\"},{\"label\":\"Large ribosomal subunit protein eL19\",\"id\":\"P84098\"},{\"label\":\"Large ribosomal subunit protein eL20\",\"id\":\"Q02543\"},{\"label\":\"Large ribosomal subunit protein eL21\",\"id\":\"P46778\"},{\"label\":\"Large ribosomal subunit protein eL22\",\"id\":\"P35268\"},{\"label\":\"Large ribosomal subunit protein eL24\",\"id\":\"P83731\"},{\"label\":\"Large ribosomal subunit protein eL27\",\"id\":\"P61353\"},{\"label\":\"Large ribosomal subunit protein eL28\",\"id\":\"P46779\"},{\"label\":\"Large ribosomal subunit protein 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2\",\"id\":\"Q9HAU5\"},{\"label\":\"Regulator of nonsense transcripts 3A\",\"id\":\"Q9H1J1\"},{\"label\":\"Regulator of nonsense transcripts 3B\",\"id\":\"Q9BZI7\"},{\"label\":\"Ribosomal protein eL22-like\",\"id\":\"Q6P5R6\"},{\"label\":\"Ribosomal protein eL39-like 2\",\"id\":\"Q96EH5\"},{\"label\":\"Ribosomal protein eL42-like\",\"id\":\"Q969Q0\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Ribosomal protein uL16-like\",\"id\":\"Q96L21\"},{\"label\":\"Ribosomal protein uL24-like\",\"id\":\"Q9UNX3\"},{\"label\":\"Ribosomal protein uL3-like\",\"id\":\"Q92901\"},{\"label\":\"Roundabout homolog 1\",\"id\":\"Q9Y6N7\"},{\"label\":\"Roundabout homolog 2\",\"id\":\"Q9HCK4\"},{\"label\":\"Slit homolog 1 protein\",\"id\":\"O75093\"},{\"label\":\"Slit homolog 2 protein\",\"id\":\"O94813\"},{\"label\":\"Small ribosomal subunit protein eS10\",\"id\":\"P46783\"},{\"label\":\"Small ribosomal subunit protein eS12\",\"id\":\"P25398\"},{\"label\":\"Small ribosomal subunit protein eS17\",\"id\":\"P08708\"},{\"label\":\"Small ribosomal subunit protein eS19\",\"id\":\"P39019\"},{\"label\":\"Small ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS32\",\"id\":\"P62945\"},{\"label\":\"Small ribosomal subunit protein eS4, X isoform\",\"id\":\"P62701\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 1\",\"id\":\"P22090\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 2\",\"id\":\"Q8TD47\"},{\"label\":\"Small ribosomal subunit protein 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"gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Metalloprotease DUBs", "protein_name": "[{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"AMSH-like protease\",\"id\":\"Q96FJ0\"},{\"label\":\"BRCA1-A complex subunit Abraxas 1\",\"id\":\"Q6UWZ7\"},{\"label\":\"BRCA1-A complex subunit RAP80\",\"id\":\"Q96RL1\"},{\"label\":\"BRCA1-associated RING domain protein 1\",\"id\":\"Q99728\"},{\"label\":\"BRISC and BRCA1-A complex member 1\",\"id\":\"Q9NWV8\"},{\"label\":\"BRISC and BRCA1-A complex member 2\",\"id\":\"Q9NXR7\"},{\"label\":\"BRISC complex subunit Abraxas 2\",\"id\":\"Q15018\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"},{\"label\":\"Deubiquitinase MYSM1\",\"id\":\"Q5VVJ2\"},{\"label\":\"Histone H2A type 1-A\",\"id\":\"Q96QV6\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-H\",\"id\":\"Q96KK5\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 1\",\"id\":\"P0C0S8\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-B\",\"id\":\"Q8IUE6\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A type 3\",\"id\":\"Q7L7L0\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Lys-63-specific deubiquitinase BRCC36\",\"id\":\"P46736\"},{\"label\":\"NACHT, LRR and PYD domains-containing protein 3\",\"id\":\"Q96P20\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"STAM-binding protein\",\"id\":\"O95630\"},{\"label\":\"Signal transducing adapter molecule 1\",\"id\":\"Q92783\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00487\",\"O95630\",\"P04908\",\"P0C0S8\",\"P0CG47\",\"P0CG48\",\"P20671\",\"P38398\",\"P46736\",\"P62979\",\"P62987\",\"Q09472\",\"Q15018\",\"Q16777\",\"Q5VVJ2\",\"Q6FI13\",\"Q6UWZ7\",\"Q7L7L0\",\"Q8IUE6\",\"Q92783\",\"Q92831\",\"Q93077\",\"Q96FJ0\",\"Q96KK5\",\"Q96P20\",\"Q96QV6\",\"Q96RL1\",\"Q99728\",\"Q99878\",\"Q9NWV8\",\"Q9NXR7\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective MPDU1 causes CDG-1f", "protein_name": "[{\"label\":\"Mannose-P-dolichol utilization defect 1 protein\",\"id\":\"O75352\"}]", "uniprot_id": "[\"O75352\"]", "gene_symbol": "[\"MPDU1\"]", "gtc_id": "[\"G59406KS\"]" }, { "pathway_label": "Downregulation of ERBB4 signaling", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase Itchy homolog\",\"id\":\"Q96J02\"},{\"label\":\"E3 ubiquitin-protein ligase NEDD4\",\"id\":\"P46934\"},{\"label\":\"NEDD4-like E3 ubiquitin-protein ligase WWP1\",\"id\":\"Q9H0M0\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1t\",\"id\":\"Q16695\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Methyl-CpG-binding domain protein 4\",\"id\":\"O95243\"},{\"label\":\"N-glycosylase/DNA lyase\",\"id\":\"O15527\"},{\"label\":\"Protection of telomeres protein 1\",\"id\":\"Q9NUX5\"},{\"label\":\"Single-strand selective monofunctional uracil DNA glycosylase\",\"id\":\"Q53HV7\"},{\"label\":\"TERF1-interacting nuclear factor 2\",\"id\":\"Q9BSI4\"},{\"label\":\"Telomeric repeat-binding factor 1\",\"id\":\"P54274\"},{\"label\":\"Telomeric repeat-binding factor 2-interacting protein 1\",\"id\":\"Q9NYB0\"},{\"label\":\"Telomeric repeat-binding factor 2\",\"id\":\"Q15554\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Endosomal/Vacuolar pathway", "protein_name": "[{\"label\":\"Beta-2-microglobulin\",\"id\":\"P61769\"},{\"label\":\"Cathepsin L2\",\"id\":\"O60911\"},{\"label\":\"Cathepsin S\",\"id\":\"P25774\"},{\"label\":\"HLA class I histocompatibility antigen, A alpha chain\",\"id\":\"P04439\"},{\"label\":\"HLA class I histocompatibility antigen, B alpha chain\",\"id\":\"P01889\"},{\"label\":\"HLA class I histocompatibility antigen, C alpha chain\",\"id\":\"P10321\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain E\",\"id\":\"P13747\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain F\",\"id\":\"P30511\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain G\",\"id\":\"P17693\"},{\"label\":\"Leucyl-cystinyl aminopeptidase\",\"id\":\"Q9UIQ6\"},{\"label\":\"Procathepsin L\",\"id\":\"P07711\"},{\"label\":\"Putative HLA class I histocompatibility antigen, alpha chain H\",\"id\":\"P01893\"}]", "uniprot_id": 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I\",\"id\":\"P12314\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant gamma 1\",\"id\":\"P01857\"},{\"label\":\"Immunoglobulin heavy constant gamma 2\",\"id\":\"P01859\"},{\"label\":\"Immunoglobulin heavy constant gamma 3\",\"id\":\"P01860\"},{\"label\":\"Immunoglobulin heavy constant gamma 4\",\"id\":\"P01861\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 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hydrolase-like protein 1\",\"id\":\"O43865\"},{\"label\":\"T-cell surface glycoprotein CD3 gamma chain\",\"id\":\"P09693\"},{\"label\":\"Tyrosine-protein kinase SYK\",\"id\":\"P43405\"},{\"label\":\"UGa8H (Fragment)\",\"id\":\"A2KUC3\"},{\"label\":\"V1-11 protein (Fragment)\",\"id\":\"Q5NV67\"},{\"label\":\"V1-13 protein (Fragment)\",\"id\":\"Q5NV69\"},{\"label\":\"V1-16 protein (Fragment)\",\"id\":\"Q5NV81\"},{\"label\":\"V1-20 protein (Fragment)\",\"id\":\"Q5NV86\"},{\"label\":\"V1-3 protein (Fragment)\",\"id\":\"Q5NV84\"},{\"label\":\"V1-5 protein (Fragment)\",\"id\":\"Q5NV65\"},{\"label\":\"V1-7 protein (Fragment)\",\"id\":\"Q5NV89\"},{\"label\":\"V1-9 protein (Fragment)\",\"id\":\"Q5NV66\"},{\"label\":\"V2-11 protein (Fragment)\",\"id\":\"Q5NV64\"},{\"label\":\"V2-15 protein (Fragment)\",\"id\":\"Q5NV75\"},{\"label\":\"V2-17 protein (Fragment)\",\"id\":\"Q5NV90\"},{\"label\":\"V2-19 protein (Fragment)\",\"id\":\"Q5NV91\"},{\"label\":\"V2-8 protein (Fragment)\",\"id\":\"Q5NV85\"},{\"label\":\"V3-2 protein (Fragment)\",\"id\":\"Q5NV80\"},{\"label\":\"V3-3 protein (Fragment)\",\"id\":\"Q5NV83\"},{\"label\":\"V3-4 protein (Fragment)\",\"id\":\"Q5NV62\"},{\"label\":\"V4-1 protein (Fragment)\",\"id\":\"Q5NV68\"},{\"label\":\"V4-2 protein (Fragment)\",\"id\":\"Q5NV82\"},{\"label\":\"V4-6 protein (Fragment)\",\"id\":\"Q5NV87\"},{\"label\":\"V5-1 protein (Fragment)\",\"id\":\"Q5NV61\"},{\"label\":\"V5-4 protein (Fragment)\",\"id\":\"Q5NV79\"},{\"label\":\"V5-6 protein (Fragment)\",\"id\":\"Q5NV92\"}]", "uniprot_id": 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mitochondrial\",\"id\":\"Q8IYU8\"},{\"label\":\"Citrate synthase, mitochondrial\",\"id\":\"O75390\"},{\"label\":\"Coiled-coil-helix-coiled-coil-helix domain-containing protein 2\",\"id\":\"Q9Y6H1\"},{\"label\":\"Cytochrome b-c1 complex subunit 2, mitochondrial\",\"id\":\"P22695\"},{\"label\":\"Cytochrome b-c1 complex subunit 8\",\"id\":\"O14949\"},{\"label\":\"Cytochrome c oxidase subunit 1\",\"id\":\"P00395\"},{\"label\":\"Cytochrome c oxidase subunit 2\",\"id\":\"P00403\"},{\"label\":\"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial\",\"id\":\"P13073\"},{\"label\":\"Cytochrome c oxidase subunit 5A, mitochondrial\",\"id\":\"P20674\"},{\"label\":\"Cytochrome c oxidase subunit 5B, mitochondrial\",\"id\":\"P10606\"},{\"label\":\"D-beta-hydroxybutyrate dehydrogenase, mitochondrial\",\"id\":\"Q02338\"},{\"label\":\"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial\",\"id\":\"Q13011\"},{\"label\":\"Delta-1-pyrroline-5-carboxylate synthase\",\"id\":\"P54886\"},{\"label\":\"Dihydrolipoyl dehydrogenase, mitochondrial\",\"id\":\"P09622\"},{\"label\":\"Dynamin-like GTPase OPA1, mitochondrial\",\"id\":\"O60313\"},{\"label\":\"Enoyl-CoA delta isomerase 1, mitochondrial\",\"id\":\"P42126\"},{\"label\":\"Essential MCU regulator, mitochondrial\",\"id\":\"Q9H4I9\"},{\"label\":\"Ferrochelatase, mitochondrial\",\"id\":\"P22830\"},{\"label\":\"Fumarate hydratase, mitochondrial\",\"id\":\"P07954\"},{\"label\":\"Glutamate dehydrogenase 1, mitochondrial\",\"id\":\"P00367\"},{\"label\":\"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial\",\"id\":\"Q16836\"},{\"label\":\"Hydroxymethylglutaryl-CoA synthase, mitochondrial\",\"id\":\"P54868\"},{\"label\":\"Isobutyryl-CoA dehydrogenase, mitochondrial\",\"id\":\"Q9UKU7\"},{\"label\":\"Isocitrate dehydrogenase [NADP], mitochondrial\",\"id\":\"P48735\"},{\"label\":\"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial\",\"id\":\"P50213\"},{\"label\":\"Isoleucine--tRNA ligase, mitochondrial\",\"id\":\"Q9NSE4\"},{\"label\":\"Large ribosomal subunit protein bL12m\",\"id\":\"P52815\"},{\"label\":\"Large ribosomal subunit protein bL32m\",\"id\":\"Q9BYC8\"},{\"label\":\"Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial\",\"id\":\"P11182\"},{\"label\":\"Lon protease homolog, mitochondrial\",\"id\":\"P36776\"},{\"label\":\"Malate dehydrogenase, mitochondrial\",\"id\":\"P40926\"},{\"label\":\"Metalloendopeptidase OMA1, mitochondrial\",\"id\":\"Q96E52\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim10\",\"id\":\"P62072\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim17-A\",\"id\":\"Q99595\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim22\",\"id\":\"Q9Y584\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim9\",\"id\":\"Q9Y5J7\"},{\"label\":\"Mitochondrial inner membrane m-AAA protease component AFG3L2\",\"id\":\"Q9Y4W6\"},{\"label\":\"Mitochondrial inner membrane m-AAA protease component paraplegin\",\"id\":\"Q9UQ90\"},{\"label\":\"Mitochondrial-processing peptidase subunit alpha\",\"id\":\"Q10713\"},{\"label\":\"NAD kinase 2, mitochondrial\",\"id\":\"Q4G0N4\"},{\"label\":\"NAD-dependent malic enzyme, mitochondrial\",\"id\":\"P23368\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13\",\"id\":\"Q9P0J0\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2\",\"id\":\"O43678\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6\",\"id\":\"O95139\"},{\"label\":\"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial\",\"id\":\"P49821\"},{\"label\":\"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial\",\"id\":\"P56181\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial\",\"id\":\"O75489\"},{\"label\":\"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial\",\"id\":\"P28331\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 1\",\"id\":\"P03886\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 2\",\"id\":\"P03891\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 5\",\"id\":\"P03915\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 6\",\"id\":\"P03923\"},{\"label\":\"PRELI domain-containing protein 1, mitochondrial\",\"id\":\"Q9Y255\"},{\"label\":\"Probable D-lactate dehydrogenase, mitochondrial\",\"id\":\"Q86WU2\"},{\"label\":\"Propionyl-CoA carboxylase beta chain, mitochondrial\",\"id\":\"P05166\"},{\"label\":\"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial\",\"id\":\"P08559\"},{\"label\":\"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial\",\"id\":\"P11177\"},{\"label\":\"Serine hydroxymethyltransferase, mitochondrial\",\"id\":\"P34897\"},{\"label\":\"Serine protease HTRA2, mitochondrial\",\"id\":\"O43464\"},{\"label\":\"Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P45954\"},{\"label\":\"Single-stranded DNA-binding protein, mitochondrial\",\"id\":\"Q04837\"},{\"label\":\"Small ribosomal subunit protein uS10m\",\"id\":\"P82664\"},{\"label\":\"Small ribosomal subunit protein uS2m\",\"id\":\"Q9Y399\"},{\"label\":\"StAR-related lipid transfer protein 7, mitochondrial\",\"id\":\"Q9NQZ5\"},{\"label\":\"Steroidogenic acute regulatory protein, mitochondrial\",\"id\":\"P49675\"},{\"label\":\"Stress-70 protein, mitochondrial\",\"id\":\"P38646\"},{\"label\":\"Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial\",\"id\":\"Q96I99\"},{\"label\":\"Succinyl-CoA\",\"id\":\"3-ketoacid coenzyme A transferase 1, mitochondrial:P55809\"},{\"label\":\"TP53-regulated inhibitor of apoptosis 1\",\"id\":\"O43715\"},{\"label\":\"Transcription factor A, mitochondrial\",\"id\":\"Q00059\"},{\"label\":\"Twinkle mtDNA helicase\",\"id\":\"Q96RR1\"},{\"label\":\"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, 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"gtc_id": "[\"\"]" }, { "pathway_label": "Mineralocorticoid biosynthesis", "protein_name": "[{\"label\":\"3 beta-hydroxysteroid dehydrogenase/Delta 5--\\u003e4-isomerase type 1\",\"id\":\"P14060\"},{\"label\":\"3 beta-hydroxysteroid dehydrogenase/Delta 5--\\u003e4-isomerase type 2\",\"id\":\"P26439\"},{\"label\":\"Cytochrome P450 11B2, mitochondrial\",\"id\":\"P19099\"},{\"label\":\"Glycoprotein hormones alpha chain\",\"id\":\"P01215\"},{\"label\":\"Lutropin subunit beta\",\"id\":\"P01229\"},{\"label\":\"Steroid 21-hydroxylase\",\"id\":\"P08686\"}]", "uniprot_id": "[\"P01215\",\"P01229\",\"P08686\",\"P14060\",\"P19099\",\"P26439\"]", "gene_symbol": "[\"3BH\",\"CGA\",\"CYP11B2\",\"CYP21\",\"CYP21A2\",\"CYP21B\",\"HSD3B1\",\"HSD3B2\",\"HSDB3A\",\"HSDB3B\",\"LHB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cation-coupled Chloride cotransporters", "protein_name": "[{\"label\":\"Solute carrier family 12 member 1\",\"id\":\"Q13621\"},{\"label\":\"Solute carrier family 12 member 2\",\"id\":\"P55011\"},{\"label\":\"Solute carrier family 12 member 3\",\"id\":\"P55017\"},{\"label\":\"Solute carrier family 12 member 4\",\"id\":\"Q9UP95\"},{\"label\":\"Solute carrier family 12 member 5\",\"id\":\"Q9H2X9\"},{\"label\":\"Solute carrier family 12 member 6\",\"id\":\"Q9UHW9\"},{\"label\":\"Solute carrier family 12 member 7\",\"id\":\"Q9Y666\"}]", "uniprot_id": "[\"P55011\",\"P55017\",\"Q13621\",\"Q9H2X9\",\"Q9UHW9\",\"Q9UP95\",\"Q9Y666\"]", "gene_symbol": "[\"KCC1\",\"KCC2\",\"KCC3\",\"KCC4\",\"KIAA1176\",\"NCC\",\"NKCC1\",\"NKCC2\",\"SLC12A1\",\"SLC12A2\",\"SLC12A3\",\"SLC12A4\",\"SLC12A5\",\"SLC12A6\",\"SLC12A7\",\"TSC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CLEC7A/inflammasome pathway", "protein_name": "[{\"label\":\"Apoptosis-associated speck-like protein containing a CARD\",\"id\":\"Q9ULZ3\"},{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"Interleukin-1 beta\",\"id\":\"P01584\"},{\"label\":\"Mucosa-associated lymphoid tissue lymphoma translocation protein 1\",\"id\":\"Q9UDY8\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": "[\"P01584\",\"P19838\",\"Q04206\",\"Q14790\",\"Q9UDY8\",\"Q9ULZ3\"]", "gene_symbol": "[\"ASC\",\"CARD5\",\"CASP8\",\"IL1B\",\"IL1F2\",\"MALT1\",\"MCH5\",\"MLT\",\"NFKB1\",\"NFKB3\",\"PYCARD\",\"RELA\",\"TMS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives", "protein_name": "[{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"},{\"label\":\"Prostaglandin G/H synthase 2\",\"id\":\"P35354\"}]", "uniprot_id": "[\"P09917\",\"P35354\"]", "gene_symbol": "[\"ALOX5\",\"COX2\",\"LOG5\",\"PTGS2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "protein_name": "[{\"label\":\"65 kDa phosphoprotein\",\"id\":\"P06725\"},{\"label\":\"Antigen-presenting glycoprotein CD1d\",\"id\":\"P15813\"},{\"label\":\"B-cell receptor CD22\",\"id\":\"P20273\"},{\"label\":\"B-lymphocyte antigen CD19\",\"id\":\"P15391\"},{\"label\":\"Beta-2-microglobulin\",\"id\":\"P61769\"},{\"label\":\"C-type lectin domain family 2 member B\",\"id\":\"Q92478\"},{\"label\":\"C-type lectin domain family 2 member D\",\"id\":\"Q9UHP7\"},{\"label\":\"C-type lectin domain family 4 member G\",\"id\":\"Q6UXB4\"},{\"label\":\"CD160 antigen\",\"id\":\"O95971\"},{\"label\":\"CD21 protein (Fragment)\",\"id\":\"O15181\"},{\"label\":\"CD226 antigen\",\"id\":\"Q15762\"},{\"label\":\"CD40 ligand\",\"id\":\"P29965\"},{\"label\":\"CD81 antigen\",\"id\":\"P60033\"},{\"label\":\"CD99 antigen\",\"id\":\"P14209\"},{\"label\":\"CMRF35-like molecule 1\",\"id\":\"Q8TDQ1\"},{\"label\":\"CMRF35-like molecule 2\",\"id\":\"Q496F6\"},{\"label\":\"CMRF35-like molecule 5\",\"id\":\"Q6UXZ3\"},{\"label\":\"CMRF35-like molecule 6\",\"id\":\"Q08708\"},{\"label\":\"CMRF35-like molecule 7\",\"id\":\"A8K4G0\"},{\"label\":\"CMRF35-like molecule 8\",\"id\":\"Q9UGN4\"},{\"label\":\"CMRF35-like molecule 9\",\"id\":\"Q6UXG3\"},{\"label\":\"Cadherin-1\",\"id\":\"P12830\"},{\"label\":\"Cell surface glycoprotein CD200 receptor 1\",\"id\":\"Q8TD46\"},{\"label\":\"Collectin-12\",\"id\":\"Q5KU26\"},{\"label\":\"Complement C3\",\"id\":\"P01024\"},{\"label\":\"Coxsackievirus and adenovirus receptor\",\"id\":\"P78310\"},{\"label\":\"Cytotoxic and regulatory T-cell molecule\",\"id\":\"O95727\"},{\"label\":\"HLA class I histocompatibility antigen, A alpha chain\",\"id\":\"P04439\"},{\"label\":\"HLA class I histocompatibility antigen, B alpha chain\",\"id\":\"P01889\"},{\"label\":\"HLA class I histocompatibility antigen, C alpha chain\",\"id\":\"P10321\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain E\",\"id\":\"P13747\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain F\",\"id\":\"P30511\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain G\",\"id\":\"P17693\"},{\"label\":\"Hemagglutinin-neuraminidase\",\"id\":\"P04853\"},{\"label\":\"Hemagglutinin\",\"id\":\"P03452\"},{\"label\":\"Hematopoietic cell signal transducer\",\"id\":\"Q9UBK5\"},{\"label\":\"High affinity immunoglobulin gamma Fc receptor I\",\"id\":\"P12314\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy 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endogenous ligand", "protein_name": "[{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Fibrinogen alpha chain\",\"id\":\"P02671\"},{\"label\":\"Fibrinogen beta chain\",\"id\":\"P02675\"},{\"label\":\"Fibrinogen gamma chain\",\"id\":\"P02679\"},{\"label\":\"Gasdermin-D\",\"id\":\"P57764\"},{\"label\":\"Gasdermin-E\",\"id\":\"O60443\"},{\"label\":\"High mobility group protein B1\",\"id\":\"P09429\"},{\"label\":\"Lipopolysaccharide-binding protein\",\"id\":\"P18428\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Platelet glycoprotein 4\",\"id\":\"P16671\"},{\"label\":\"Protein S100-A1\",\"id\":\"P23297\"},{\"label\":\"Protein S100-A8\",\"id\":\"P05109\"},{\"label\":\"Protein S100-A9\",\"id\":\"P06702\"},{\"label\":\"Toll-like receptor 1\",\"id\":\"Q15399\"},{\"label\":\"Toll-like receptor 2\",\"id\":\"O60603\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Toll-like receptor 6\",\"id\":\"Q9Y2C9\"},{\"label\":\"Toll-like receptor 7\",\"id\":\"Q9NYK1\"}]", "uniprot_id": "[\"O00206\",\"O60443\",\"O60603\",\"P02671\",\"P02675\",\"P02679\",\"P04114\",\"P05109\",\"P06702\",\"P08571\",\"P09429\",\"P16671\",\"P18428\",\"P23297\",\"P57764\",\"Q15399\",\"Q9NYK1\",\"Q9Y2C9\",\"Q9Y6Y9\"]", "gene_symbol": "[\"APOB\",\"CAGA\",\"CAGB\",\"CD14\",\"CD36\",\"CFAG\",\"DFNA5\",\"DFNA5L\",\"ESOP1\",\"FGA\",\"FGB\",\"FGG\",\"GP3B\",\"GP4\",\"GSDMD\",\"GSDMDC1\",\"GSDME\",\"HMG1\",\"HMGB1\",\"ICERE1\",\"KIAA0012\",\"LBP\",\"LY96\",\"MD2\",\"MRP14\",\"MRP8\",\"S100A\",\"S100A1\",\"S100A8\",\"S100A9\",\"TIL4\",\"TLR1\",\"TLR2\",\"TLR4\",\"TLR6\",\"TLR7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Frs2-mediated activation", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"Crk-like protein\",\"id\":\"P46109\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 1\",\"id\":\"Q02750\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 2\",\"id\":\"P36507\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Rap guanine nucleotide exchange factor 1\",\"id\":\"Q13905\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"}]", "uniprot_id": "[\"P01138\",\"P15056\",\"P27361\",\"P28482\",\"P31946\",\"P36507\",\"P46109\",\"P62834\",\"Q02750\",\"Q13905\",\"Q8WU20\"]", "gene_symbol": "[\"BRAF\",\"BRAF1\",\"CRKL\",\"ERK1\",\"ERK2\",\"FRS2\",\"GRF2\",\"KREV1\",\"MAP2K1\",\"MAP2K2\",\"MAPK1\",\"MAPK3\",\"MEK1\",\"MEK2\",\"MKK2\",\"NGF\",\"NGFB\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"PRKMK1\",\"PRKMK2\",\"RAFB1\",\"RAP1A\",\"RAPGEF1\",\"YWHAB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Maturation of spike protein", "protein_name": "[{\"label\":\"Alpha-(1,6)-fucosyltransferase\",\"id\":\"Q9BYC5\"},{\"label\":\"Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\",\"id\":\"P26572\"},{\"label\":\"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A\",\"id\":\"Q9UM21\"},{\"label\":\"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B\",\"id\":\"Q9UQ53\"},{\"label\":\"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C\",\"id\":\"Q9UBM8\"},{\"label\":\"Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\",\"id\":\"Q10469\"},{\"label\":\"Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A\",\"id\":\"Q09328\"},{\"label\":\"Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase\",\"id\":\"Q9H4F1\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2\",\"id\":\"Q9UJ37\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3\",\"id\":\"Q8NDV1\"},{\"label\":\"Alpha-mannosidase 2\",\"id\":\"Q16706\"},{\"label\":\"Beta-galactoside alpha-2,6-sialyltransferase 1\",\"id\":\"P15907\"},{\"label\":\"CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase\",\"id\":\"Q11203\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1\",\"id\":\"Q11201\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2\",\"id\":\"Q16842\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4\",\"id\":\"Q11206\"},{\"label\":\"Calnexin\",\"id\":\"P27824\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit\",\"id\":\"P39656\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1\",\"id\":\"P04843\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2\",\"id\":\"P04844\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1\",\"id\":\"P61803\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A\",\"id\":\"P46977\"},{\"label\":\"ER degradation-enhancing alpha-mannosidase-like protein 2\",\"id\":\"Q9BV94\"},{\"label\":\"Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase\",\"id\":\"Q9UKM7\"},{\"label\":\"Glucosidase 2 subunit beta\",\"id\":\"P14314\"},{\"label\":\"Golgin subfamily A member 7\",\"id\":\"Q7Z5G4\"},{\"label\":\"Magnesium transporter protein 1\",\"id\":\"Q9H0U3\"},{\"label\":\"Mannosyl-oligosaccharide glucosidase\",\"id\":\"Q13724\"},{\"label\":\"Neutral alpha-glucosidase AB\",\"id\":\"Q14697\"},{\"label\":\"Palmitoyltransferase ZDHHC11\",\"id\":\"Q9H8X9\"},{\"label\":\"Palmitoyltransferase ZDHHC20\",\"id\":\"Q5W0Z9\"},{\"label\":\"Palmitoyltransferase ZDHHC2\",\"id\":\"Q9UIJ5\"},{\"label\":\"Palmitoyltransferase ZDHHC3\",\"id\":\"Q9NYG2\"},{\"label\":\"Palmitoyltransferase ZDHHC5\",\"id\":\"Q9C0B5\"},{\"label\":\"Palmitoyltransferase ZDHHC8\",\"id\":\"Q9ULC8\"},{\"label\":\"Palmitoyltransferase ZDHHC9\",\"id\":\"Q9Y397\"},{\"label\":\"Spike glycoprotein\",\"id\":\"P0DTC2\"},{\"label\":\"Tumor suppressor candidate 3\",\"id\":\"Q13454\"}]", "uniprot_id": 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"[\"C20orf31\",\"C20orf49\",\"CANX\",\"CGS23\",\"CXorf11\",\"DAD1\",\"DDOST\",\"EDEM2\",\"FUT8\",\"G19P1\",\"G2AN\",\"GANAB\",\"GCP16\",\"GCS1\",\"GGNT1\",\"GGNT5\",\"GLCT1\",\"GLYT1\",\"GOLGA7\",\"IAG2\",\"ITM1\",\"KIAA0088\",\"KIAA0115\",\"KIAA1292\",\"KIAA1748\",\"MAGT1\",\"MAN1B1\",\"MAN2A1\",\"MANA2\",\"MGAT\",\"MGAT1\",\"MGAT2\",\"MGAT4A\",\"MGAT4B\",\"MGAT4C\",\"MGAT5\",\"MOGS\",\"N33\",\"NANTA3\",\"OST48\",\"PRKCSH\",\"REAM\",\"REC\",\"RPN1\",\"RPN2\",\"S\",\"SIAT1\",\"SIAT3C\",\"SIAT4\",\"SIAT4A\",\"SIAT4B\",\"SIAT4C\",\"SIAT6\",\"SIAT7B\",\"SIAT7C\",\"SIAT7D\",\"SIATL1\",\"ST3GAL1\",\"ST3GAL2\",\"ST3GAL3\",\"ST3GAL4\",\"ST6GAL1\",\"ST6GALNAC2\",\"ST6GALNAC3\",\"ST6GALNAC4\",\"STHM\",\"STT3A\",\"STZ\",\"TMC\",\"TUSC3\",\"ZDHHC10\",\"ZDHHC11\",\"ZDHHC2\",\"ZDHHC20\",\"ZDHHC3\",\"ZDHHC5\",\"ZDHHC8\",\"ZDHHC9\",\"ZDHHCL1\",\"ZNF372\",\"ZNF375\",\"ZNF378\",\"ZNF379\",\"ZNF380\",\"ZNF399\"]", "gtc_id": "[\"G71142DF\"]" }, { "pathway_label": "Postmitotic nuclear pore complex (NPC) reformation", "protein_name": "[{\"label\":\"GTP-binding nuclear protein Ran\",\"id\":\"P62826\"},{\"label\":\"Importin subunit beta-1\",\"id\":\"Q14974\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Protein ELYS\",\"id\":\"Q8WYP5\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Ran GTPase-activating protein 1\",\"id\":\"P46060\"},{\"label\":\"Regulator of chromosome condensation\",\"id\":\"P18754\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"},{\"label\":\"Transportin-1\",\"id\":\"Q92973\"}]", "uniprot_id": "[\"O75694\",\"P18754\",\"P37198\",\"P46060\",\"P55735\",\"P57740\",\"P62826\",\"P63165\",\"P63279\",\"Q12769\",\"Q14974\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8N1F7\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8WUM0\",\"Q8WYP5\",\"Q92621\",\"Q92973\",\"Q96HA1\",\"Q9BTX1\",\"Q9BW27\"]", "gene_symbol": 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3\",\"id\":\"Q12873\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 4\",\"id\":\"Q14839\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H3.3\",\"id\":\"P84243\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone deacetylase 2\",\"id\":\"Q92769\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Histone-binding protein RBBP7\",\"id\":\"Q16576\"},{\"label\":\"Histone-lysine N-methyltransferase SETDB1\",\"id\":\"Q15047\"},{\"label\":\"Metastasis-associated protein MTA1\",\"id\":\"Q13330\"},{\"label\":\"Metastasis-associated protein MTA2\",\"id\":\"O94776\"},{\"label\":\"Metastasis-associated protein MTA3\",\"id\":\"Q9BTC8\"},{\"label\":\"Methyl-CpG-binding domain protein 3\",\"id\":\"O95983\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 2\",\"id\":\"P61956\"},{\"label\":\"Transcription intermediary factor 1-beta\",\"id\":\"Q13263\"},{\"label\":\"Transcriptional repressor p66-alpha\",\"id\":\"Q86YP4\"},{\"label\":\"Transcriptional repressor p66-beta\",\"id\":\"Q8WXI9\"},{\"label\":\"Zinc finger protein 136\",\"id\":\"P52737\"},{\"label\":\"Zinc finger protein 141\",\"id\":\"Q15928\"},{\"label\":\"Zinc finger protein 224\",\"id\":\"Q9NZL3\"},{\"label\":\"Zinc finger protein 257\",\"id\":\"Q9Y2Q1\"},{\"label\":\"Zinc finger protein 264\",\"id\":\"O43296\"},{\"label\":\"Zinc finger protein 273\",\"id\":\"Q14593\"},{\"label\":\"Zinc finger protein 28\",\"id\":\"P17035\"},{\"label\":\"Zinc finger protein 30\",\"id\":\"P17039\"},{\"label\":\"Zinc finger protein 317\",\"id\":\"Q96PQ6\"},{\"label\":\"Zinc finger protein 320\",\"id\":\"A2RRD8\"},{\"label\":\"Zinc finger protein 324A\",\"id\":\"O75467\"},{\"label\":\"Zinc finger protein 331\",\"id\":\"Q9NQX6\"},{\"label\":\"Zinc finger protein 33A\",\"id\":\"Q06730\"},{\"label\":\"Zinc finger protein 354A\",\"id\":\"O60765\"},{\"label\":\"Zinc finger protein 382\",\"id\":\"Q96SR6\"},{\"label\":\"Zinc finger protein 418\",\"id\":\"Q8TF45\"},{\"label\":\"Zinc finger protein 425\",\"id\":\"Q6IV72\"},{\"label\":\"Zinc finger protein 454\",\"id\":\"Q8N9F8\"},{\"label\":\"Zinc finger protein 519\",\"id\":\"Q8TB69\"},{\"label\":\"Zinc finger protein 534\",\"id\":\"Q76KX8\"},{\"label\":\"Zinc finger protein 547\",\"id\":\"Q8IVP9\"},{\"label\":\"Zinc finger protein 610\",\"id\":\"Q8N9Z0\"},{\"label\":\"Zinc finger protein 649\",\"id\":\"Q9BS31\"},{\"label\":\"Zinc finger protein 669\",\"id\":\"Q96BR6\"},{\"label\":\"Zinc finger protein 680\",\"id\":\"Q8NEM1\"},{\"label\":\"Zinc finger protein 708\",\"id\":\"P17019\"},{\"label\":\"Zinc finger protein 765\",\"id\":\"Q7L2R6\"},{\"label\":\"Zinc finger protein 778\",\"id\":\"Q96MU6\"},{\"label\":\"Zinc finger protein 816\",\"id\":\"Q0VGE8\"},{\"label\":\"Zinc finger protein 93\",\"id\":\"P35789\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by FGFR3 fusions in cancer", "protein_name": "[{\"label\":\"Fibroblast growth factor receptor 3\",\"id\":\"P22607\"}]", "uniprot_id": "[\"P22607\"]", "gene_symbol": "[\"FGFR3\",\"JTK4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Classical antibody-mediated complement activation", "protein_name": "[{\"label\":\"C-reactive protein\",\"id\":\"P02741\"},{\"label\":\"Complement C1q subcomponent subunit A\",\"id\":\"P02745\"},{\"label\":\"Complement C1q subcomponent subunit B\",\"id\":\"P02746\"},{\"label\":\"Complement C1q subcomponent subunit C\",\"id\":\"P02747\"},{\"label\":\"Complement C1r subcomponent\",\"id\":\"P00736\"},{\"label\":\"Complement C1s subcomponent\",\"id\":\"P09871\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant gamma 1\",\"id\":\"P01857\"},{\"label\":\"Immunoglobulin heavy constant gamma 2\",\"id\":\"P01859\"},{\"label\":\"Immunoglobulin heavy constant gamma 3\",\"id\":\"P01860\"},{\"label\":\"Immunoglobulin heavy constant gamma 4\",\"id\":\"P01861\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 3-20\",\"id\":\"P01619\"},{\"label\":\"Immunoglobulin kappa variable 3D-20\",\"id\":\"A0A0C4DH25\"},{\"label\":\"Immunoglobulin kappa variable 4-1\",\"id\":\"P06312\"},{\"label\":\"Immunoglobulin kappa variable 5-2\",\"id\":\"P06315\"},{\"label\":\"Immunoglobulin lambda constant 1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 3\",\"id\":\"P0DOY3\"},{\"label\":\"Immunoglobulin lambda constant 6\",\"id\":\"P0CF74\"},{\"label\":\"Immunoglobulin lambda constant 7\",\"id\":\"A0M8Q6\"},{\"label\":\"Immunoglobulin lambda variable 1-40\",\"id\":\"P01703\"},{\"label\":\"Immunoglobulin lambda variable 1-44\",\"id\":\"P01699\"},{\"label\":\"Immunoglobulin lambda variable 1-47\",\"id\":\"P01700\"},{\"label\":\"Immunoglobulin lambda variable 1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 2-8\",\"id\":\"P01709\"},{\"label\":\"Immunoglobulin lambda variable 3-19\",\"id\":\"P01714\"},{\"label\":\"Immunoglobulin lambda variable 3-1\",\"id\":\"P01715\"},{\"label\":\"Immunoglobulin lambda variable 3-21\",\"id\":\"P80748\"},{\"label\":\"Immunoglobulin lambda variable 3-25\",\"id\":\"P01717\"},{\"label\":\"Immunoglobulin lambda variable 3-27\",\"id\":\"P01718\"},{\"label\":\"Immunoglobulin lambda variable 6-57\",\"id\":\"P01721\"},{\"label\":\"Immunoglobulin lambda variable 7-43\",\"id\":\"P04211\"},{\"label\":\"Immunolglobulin kappa light chain variable region L22 (Fragment)\",\"id\":\"A2NXD2\"},{\"label\":\"UGa8H (Fragment)\",\"id\":\"A2KUC3\"},{\"label\":\"V1-11 protein (Fragment)\",\"id\":\"Q5NV67\"},{\"label\":\"V1-13 protein (Fragment)\",\"id\":\"Q5NV69\"},{\"label\":\"V1-16 protein (Fragment)\",\"id\":\"Q5NV81\"},{\"label\":\"V1-20 protein (Fragment)\",\"id\":\"Q5NV86\"},{\"label\":\"V1-3 protein (Fragment)\",\"id\":\"Q5NV84\"},{\"label\":\"V1-5 protein (Fragment)\",\"id\":\"Q5NV65\"},{\"label\":\"V1-7 protein (Fragment)\",\"id\":\"Q5NV89\"},{\"label\":\"V1-9 protein (Fragment)\",\"id\":\"Q5NV66\"},{\"label\":\"V2-11 protein (Fragment)\",\"id\":\"Q5NV64\"},{\"label\":\"V2-15 protein (Fragment)\",\"id\":\"Q5NV75\"},{\"label\":\"V2-17 protein (Fragment)\",\"id\":\"Q5NV90\"},{\"label\":\"V2-19 protein (Fragment)\",\"id\":\"Q5NV91\"},{\"label\":\"V2-8 protein (Fragment)\",\"id\":\"Q5NV85\"},{\"label\":\"V3-2 protein (Fragment)\",\"id\":\"Q5NV80\"},{\"label\":\"V3-3 protein (Fragment)\",\"id\":\"Q5NV83\"},{\"label\":\"V3-4 protein (Fragment)\",\"id\":\"Q5NV62\"},{\"label\":\"V4-1 protein (Fragment)\",\"id\":\"Q5NV68\"},{\"label\":\"V4-2 protein (Fragment)\",\"id\":\"Q5NV82\"},{\"label\":\"V4-6 protein (Fragment)\",\"id\":\"Q5NV87\"},{\"label\":\"V5-1 protein (Fragment)\",\"id\":\"Q5NV61\"},{\"label\":\"V5-4 protein (Fragment)\",\"id\":\"Q5NV79\"},{\"label\":\"V5-6 protein (Fragment)\",\"id\":\"Q5NV92\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Loss of phosphorylation of MECP2 at T308", "protein_name": "[{\"label\":\"Calcium/calmodulin-dependent protein kinase type IV\",\"id\":\"Q16566\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"}]", "uniprot_id": "[\"P0DP23\",\"P17612\",\"Q16566\"]", "gene_symbol": "[\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAMK\",\"CAMK-GR\",\"CAMK4\",\"CAMKIV\",\"PKACA\",\"PRKACA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IKBKB deficiency causes SCID", "protein_name": "[{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"Q9Y6K9\"]", "gene_symbol": "[\"CHUK\",\"FIP3\",\"IKBKB\",\"IKBKG\",\"IKKA\",\"IKKB\",\"NEMO\",\"TCF16\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Polymerase III Abortive And Retractive Initiation", "protein_name": "[{\"label\":\"DNA-directed RNA polymerase III subunit RPC10\",\"id\":\"Q9Y2Y1\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC1\",\"id\":\"O14802\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC2\",\"id\":\"Q9NW08\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC3\",\"id\":\"Q9BUI4\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC4\",\"id\":\"P05423\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC5\",\"id\":\"Q9NVU0\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC6\",\"id\":\"Q9H1D9\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7-like\",\"id\":\"Q9BT43\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7\",\"id\":\"O15318\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC8\",\"id\":\"Q9Y535\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC9\",\"id\":\"O75575\"},{\"label\":\"DNA-directed RNA polymerases I and III subunit RPAC1\",\"id\":\"O15160\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription factor 3C polypeptide 1\",\"id\":\"Q12789\"},{\"label\":\"General transcription factor 3C polypeptide 2\",\"id\":\"Q8WUA4\"},{\"label\":\"General transcription factor 3C polypeptide 3\",\"id\":\"Q9Y5Q9\"},{\"label\":\"General transcription factor 3C polypeptide 4\",\"id\":\"Q9UKN8\"},{\"label\":\"General transcription factor 3C polypeptide 5\",\"id\":\"Q9Y5Q8\"},{\"label\":\"General transcription factor 3C polypeptide 6\",\"id\":\"Q969F1\"},{\"label\":\"Lupus La protein\",\"id\":\"P05455\"},{\"label\":\"Nuclear factor 1 A-type\",\"id\":\"Q12857\"},{\"label\":\"Nuclear factor 1 B-type\",\"id\":\"O00712\"},{\"label\":\"Nuclear factor 1 C-type\",\"id\":\"P08651\"},{\"label\":\"Nuclear factor 1 X-type\",\"id\":\"Q14938\"},{\"label\":\"POU domain, class 2, transcription factor 1\",\"id\":\"P14859\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription factor IIIA\",\"id\":\"Q92664\"},{\"label\":\"Transcription factor IIIB 50 kDa subunit\",\"id\":\"Q9HAW0\"},{\"label\":\"Transcription factor IIIB 90 kDa subunit\",\"id\":\"Q92994\"},{\"label\":\"Transcription factor TFIIIB component B'' homolog\",\"id\":\"A6H8Y1\"},{\"label\":\"Zinc finger protein 143\",\"id\":\"P52747\"},{\"label\":\"snRNA-activating protein complex subunit 1\",\"id\":\"Q16533\"},{\"label\":\"snRNA-activating protein complex subunit 2\",\"id\":\"Q13487\"},{\"label\":\"snRNA-activating protein complex subunit 3\",\"id\":\"Q92966\"},{\"label\":\"snRNA-activating protein complex subunit 4\",\"id\":\"Q5SXM2\"},{\"label\":\"snRNA-activating protein complex subunit 5\",\"id\":\"O75971\"}]", "uniprot_id": "[\"A6H8Y1\",\"O00712\",\"O14802\",\"O15160\",\"O15318\",\"O75575\",\"O75971\",\"P05423\",\"P05455\",\"P08651\",\"P0DPB5\",\"P14859\",\"P19388\",\"P20226\",\"P52434\",\"P52747\",\"P53803\",\"P61218\",\"P62875\",\"Q12789\",\"Q12857\",\"Q13487\",\"Q14938\",\"Q16533\",\"Q5SXM2\",\"Q8WUA4\",\"Q92664\",\"Q92966\",\"Q92994\",\"Q969F1\",\"Q9BT43\",\"Q9BUI4\",\"Q9H1D9\",\"Q9HAW0\",\"Q9NVU0\",\"Q9NW08\",\"Q9UKN8\",\"Q9Y2Y1\",\"Q9Y535\",\"Q9Y5Q8\",\"Q9Y5Q9\"]", "gene_symbol": 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chain\",\"id\":\"P02671\"},{\"label\":\"Fibrinogen beta chain\",\"id\":\"P02675\"},{\"label\":\"Fibrinogen gamma chain\",\"id\":\"P02679\"},{\"label\":\"Fibronectin\",\"id\":\"P02751\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Integrin alpha-IIb\",\"id\":\"P08514\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAS guanyl-releasing protein 1\",\"id\":\"O95267\"},{\"label\":\"RAS guanyl-releasing protein 2\",\"id\":\"Q7LDG7\"},{\"label\":\"Rap guanine nucleotide exchange factor 3\",\"id\":\"O95398\"},{\"label\":\"Rap guanine nucleotide exchange factor 4\",\"id\":\"Q8WZA2\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"},{\"label\":\"SHC-transforming protein 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1\",\"id\":\"Q13285\"},{\"label\":\"Transcription factor GATA-4\",\"id\":\"P43694\"},{\"label\":\"Transcription factor SOX-9\",\"id\":\"P48436\"},{\"label\":\"Wilms tumor protein\",\"id\":\"P19544\"},{\"label\":\"Zinc finger protein ZFPM2\",\"id\":\"Q8WW38\"}]", "uniprot_id": "[\"O43323\",\"P03971\",\"P19544\",\"P31371\",\"P41222\",\"P43694\",\"P48436\",\"Q05066\",\"Q13285\",\"Q8WW38\",\"Q9Y5R6\"]", "gene_symbol": "[\"AD4BP\",\"AMH\",\"DHH\",\"DMRT1\",\"DMT1\",\"FGF9\",\"FOG2\",\"FTZF1\",\"GATA4\",\"MIF\",\"NR5A1\",\"PDS\",\"PTGDS\",\"SF1\",\"SOX9\",\"SRY\",\"TDF\",\"WT1\",\"ZFPM2\",\"ZNF89B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RND2 GTPase cycle", "protein_name": "[{\"label\":\"Aldehyde dehydrogenase family 3 member A2\",\"id\":\"P51648\"},{\"label\":\"Ankyrin repeat domain-containing protein 26\",\"id\":\"Q9UPS8\"},{\"label\":\"BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1\",\"id\":\"Q8WZ19\"},{\"label\":\"BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2\",\"id\":\"Q13829\"},{\"label\":\"Bridge-like lipid transfer protein family member 3B\",\"id\":\"A0JNW5\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Cytoskeleton-associated protein 4\",\"id\":\"Q07065\"},{\"label\":\"DEP domain-containing protein 1B\",\"id\":\"Q8WUY9\"},{\"label\":\"Desmoglein-1\",\"id\":\"Q02413\"},{\"label\":\"Disks large homolog 5\",\"id\":\"Q8TDM6\"},{\"label\":\"Dystonin\",\"id\":\"Q03001\"},{\"label\":\"Ephrin type-A receptor 2\",\"id\":\"P29317\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Fibroblast growth factor receptor substrate 3\",\"id\":\"O43559\"},{\"label\":\"Formin-binding protein 1\",\"id\":\"Q96RU3\"},{\"label\":\"Golgin subfamily A member 3\",\"id\":\"Q08378\"},{\"label\":\"Inactive tyrosine-protein kinase PRAG1\",\"id\":\"Q86YV5\"},{\"label\":\"Inner nuclear membrane protein Man1\",\"id\":\"Q9Y2U8\"},{\"label\":\"Kinase D-interacting substrate of 220 kDa\",\"id\":\"Q9ULH0\"},{\"label\":\"Kinectin\",\"id\":\"Q86UP2\"},{\"label\":\"Kinesin-like protein KIF14\",\"id\":\"Q15058\"},{\"label\":\"Leucine-rich repeat-containing protein 1\",\"id\":\"Q9BTT6\"},{\"label\":\"Mucin-13\",\"id\":\"Q9H3R2\"},{\"label\":\"Nischarin\",\"id\":\"Q9Y2I1\"},{\"label\":\"Nuclear migration protein nudC\",\"id\":\"Q9Y266\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Plakophilin-4\",\"id\":\"Q99569\"},{\"label\":\"Plexin-D1\",\"id\":\"Q9Y4D7\"},{\"label\":\"Protein FAM83B\",\"id\":\"Q5T0W9\"},{\"label\":\"Protein scribble homolog\",\"id\":\"Q14160\"},{\"label\":\"RNA-binding motif protein, X chromosome\",\"id\":\"P38159\"},{\"label\":\"Rho GTPase-activating protein 1\",\"id\":\"Q07960\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho GTPase-activating protein 5\",\"id\":\"Q13017\"},{\"label\":\"Rho-related GTP-binding protein RhoN\",\"id\":\"P52198\"},{\"label\":\"Thioredoxin-like protein 1\",\"id\":\"O43396\"},{\"label\":\"Transferrin receptor protein 1\",\"id\":\"P02786\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 13\",\"id\":\"Q12923\"},{\"label\":\"UBX domain-containing protein 11\",\"id\":\"Q5T124\"},{\"label\":\"Vang-like protein 1\",\"id\":\"Q8TAA9\"},{\"label\":\"Vang-like protein 2\",\"id\":\"Q9ULK5\"},{\"label\":\"tRNA (34-2'-O)-methyltransferase regulator WDR6\",\"id\":\"Q9NNW5\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Activation of the pre-replicative complex", "protein_name": "[{\"label\":\"Cell division control protein 45 homolog\",\"id\":\"O75419\"},{\"label\":\"Cell division control protein 6 homolog\",\"id\":\"Q99741\"},{\"label\":\"Cell division cycle 7-related protein kinase\",\"id\":\"O00311\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"DNA helicase MCM8\",\"id\":\"Q9UJA3\"},{\"label\":\"DNA polymerase alpha catalytic subunit\",\"id\":\"P09884\"},{\"label\":\"DNA polymerase alpha subunit B\",\"id\":\"Q14181\"},{\"label\":\"DNA polymerase epsilon catalytic subunit A\",\"id\":\"Q07864\"},{\"label\":\"DNA polymerase epsilon subunit 2\",\"id\":\"P56282\"},{\"label\":\"DNA polymerase epsilon subunit 3\",\"id\":\"Q9NRF9\"},{\"label\":\"DNA polymerase epsilon subunit 4\",\"id\":\"Q9NR33\"},{\"label\":\"DNA primase large subunit\",\"id\":\"P49643\"},{\"label\":\"DNA primase small subunit\",\"id\":\"P49642\"},{\"label\":\"DNA replication factor Cdt1\",\"id\":\"Q9H211\"},{\"label\":\"DNA replication licensing factor MCM2\",\"id\":\"P49736\"},{\"label\":\"DNA replication licensing factor MCM3\",\"id\":\"P25205\"},{\"label\":\"DNA replication licensing factor MCM4\",\"id\":\"P33991\"},{\"label\":\"DNA replication licensing factor MCM5\",\"id\":\"P33992\"},{\"label\":\"DNA replication licensing factor MCM6\",\"id\":\"Q14566\"},{\"label\":\"DNA replication licensing factor MCM7\",\"id\":\"P33993\"},{\"label\":\"Geminin\",\"id\":\"O75496\"},{\"label\":\"Origin recognition complex subunit 1\",\"id\":\"Q13415\"},{\"label\":\"Origin recognition complex subunit 2\",\"id\":\"Q13416\"},{\"label\":\"Origin recognition complex subunit 3\",\"id\":\"Q9UBD5\"},{\"label\":\"Origin recognition complex subunit 4\",\"id\":\"O43929\"},{\"label\":\"Origin recognition complex subunit 5\",\"id\":\"O43913\"},{\"label\":\"Origin recognition complex subunit 6\",\"id\":\"Q9Y5N6\"},{\"label\":\"Protein DBF4 homolog A\",\"id\":\"Q9UBU7\"},{\"label\":\"Protein MCM10 homolog\",\"id\":\"Q7L590\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 30 kDa subunit\",\"id\":\"Q13156\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"}]", "uniprot_id": "[\"O00311\",\"O43913\",\"O43929\",\"O75419\",\"O75496\",\"P09884\",\"P15927\",\"P24941\",\"P25205\",\"P27694\",\"P33991\",\"P33992\",\"P33993\",\"P35244\",\"P49642\",\"P49643\",\"P49736\",\"P56282\",\"Q07864\",\"Q13156\",\"Q13415\",\"Q13416\",\"Q14181\",\"Q14566\",\"Q7L590\",\"Q99741\",\"Q9H211\",\"Q9NR33\",\"Q9NRF9\",\"Q9UBD5\",\"Q9UBU7\",\"Q9UJA3\",\"Q9Y5N6\"]", "gene_symbol": "[\"ASK\",\"BM28\",\"C20orf154\",\"CCNL1\",\"CDC18L\",\"CDC21\",\"CDC45\",\"CDC45L\",\"CDC45L2\",\"CDC46\",\"CDC47\",\"CDC6\",\"CDC7\",\"CDC7L1\",\"CDCL1\",\"CDK2\",\"CDKN2\",\"CDT1\",\"CHRAC17\",\"DBF4\",\"DBF4A\",\"DPE2\",\"GMNN\",\"KIAA0030\",\"LATHEO\",\"MCM10\",\"MCM2\",\"MCM3\",\"MCM4\",\"MCM5\",\"MCM6\",\"MCM7\",\"MCM8\",\"ORC1\",\"ORC1L\",\"ORC2\",\"ORC2L\",\"ORC3\",\"ORC3L\",\"ORC4\",\"ORC4L\",\"ORC5\",\"ORC5L\",\"ORC6\",\"ORC6L\",\"PARC1\",\"POLA\",\"POLA1\",\"POLA2\",\"POLE\",\"POLE1\",\"POLE2\",\"POLE3\",\"POLE4\",\"PRIM1\",\"PRIM2\",\"PRIM2A\",\"REPA1\",\"REPA2\",\"REPA3\",\"RPA1\",\"RPA14\",\"RPA2\",\"RPA3\",\"RPA32\",\"RPA34\",\"RPA4\",\"RPA70\",\"ZDBF1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ASP-3026-resistant ALK mutants", "protein_name": "[{\"label\":\"ALK tyrosine kinase receptor\",\"id\":\"Q9UM73\"}]", "uniprot_id": "[\"Q9UM73\"]", "gene_symbol": "[\"ALK\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Apoptotic cleavage of cell adhesion proteins", "protein_name": "[{\"label\":\"Cadherin-1\",\"id\":\"P12830\"},{\"label\":\"Caspase-3\",\"id\":\"P42574\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Desmoglein-1\",\"id\":\"Q02413\"},{\"label\":\"Desmoglein-2\",\"id\":\"Q14126\"},{\"label\":\"Desmoglein-3\",\"id\":\"P32926\"},{\"label\":\"Desmoplakin\",\"id\":\"P15924\"},{\"label\":\"Occludin\",\"id\":\"Q16625\"},{\"label\":\"Plakophilin-1\",\"id\":\"Q13835\"},{\"label\":\"Tight junction protein ZO-1\",\"id\":\"Q07157\"},{\"label\":\"Tight junction protein ZO-2\",\"id\":\"Q9UDY2\"}]", "uniprot_id": "[\"P12830\",\"P15924\",\"P32926\",\"P35222\",\"P42574\",\"Q02413\",\"Q07157\",\"Q13835\",\"Q14126\",\"Q16625\",\"Q9UDY2\"]", "gene_symbol": "[\"CASP3\",\"CDH1\",\"CDHE\",\"CDHF4\",\"CDHF5\",\"CDHF6\",\"CPP32\",\"CTNNB\",\"CTNNB1\",\"DSG1\",\"DSG2\",\"DSG3\",\"DSP\",\"OCLN\",\"PKP1\",\"TJP1\",\"TJP2\",\"UVO\",\"X104\",\"ZO1\",\"ZO2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TWIK-related alkaline pH activated K+ channel (TALK)", "protein_name": "[{\"label\":\"Potassium channel subfamily K member 16\",\"id\":\"Q96T55\"},{\"label\":\"Potassium channel subfamily K member 17\",\"id\":\"Q96T54\"}]", "uniprot_id": "[\"Q96T54\",\"Q96T55\"]", "gene_symbol": "[\"KCNK16\",\"KCNK17\",\"TALK1\",\"TALK2\",\"TASK4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation", "protein_name": "[{\"label\":\"6-pyruvoyl tetrahydrobiopterin synthase\",\"id\":\"Q03393\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Dihydrofolate reductase\",\"id\":\"P00374\"},{\"label\":\"GTP cyclohydrolase 1 feedback regulatory protein\",\"id\":\"P30047\"},{\"label\":\"GTP cyclohydrolase 1\",\"id\":\"P30793\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Nitric oxide synthase 3\",\"id\":\"P29474\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"Sepiapterin reductase\",\"id\":\"P35270\"},{\"label\":\"cGMP-dependent protein kinase 2\",\"id\":\"Q13237\"}]", "uniprot_id": "[\"P00374\",\"P07900\",\"P0DP23\",\"P29474\",\"P30047\",\"P30793\",\"P31749\",\"P35270\",\"Q03393\",\"Q13237\"]", "gene_symbol": "[\"AKT1\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"DHFR\",\"DYT5\",\"GCH\",\"GCH1\",\"GCHFR\",\"GFRP\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"NOS3\",\"PKB\",\"PRKG2\",\"PRKGR2\",\"PTS\",\"RAC\",\"SPR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NGF-independant TRKA activation", "protein_name": "[{\"label\":\"Adenosine receptor A2a\",\"id\":\"P29274\"},{\"label\":\"BDNF/NT-3 growth factors receptor\",\"id\":\"Q16620\"},{\"label\":\"High affinity nerve growth factor receptor\",\"id\":\"P04629\"},{\"label\":\"Pituitary adenylate cyclase-activating polypeptide type I receptor\",\"id\":\"P41586\"},{\"label\":\"Pituitary adenylate cyclase-activating polypeptide\",\"id\":\"P18509\"}]", "uniprot_id": "[\"P04629\",\"P18509\",\"P29274\",\"P41586\",\"Q16620\"]", "gene_symbol": "[\"ADCYAP1\",\"ADCYAP1R1\",\"ADORA2\",\"ADORA2A\",\"MTC\",\"NTRK1\",\"NTRK2\",\"TRK\",\"TRKA\",\"TRKB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "protein_name": "[{\"label\":\"Cytochrome P450 1A1\",\"id\":\"P04798\"},{\"label\":\"Cytochrome P450 1A2\",\"id\":\"P05177\"},{\"label\":\"Cytochrome P450 1B1\",\"id\":\"Q16678\"},{\"label\":\"Cytochrome P450 2C19\",\"id\":\"P33261\"},{\"label\":\"Cytochrome P450 2C8\",\"id\":\"P10632\"},{\"label\":\"Cytochrome P450 2C9\",\"id\":\"P11712\"},{\"label\":\"Cytochrome P450 2U1\",\"id\":\"Q7Z449\"},{\"label\":\"Cytochrome P450 4A11\",\"id\":\"Q02928\"},{\"label\":\"Cytochrome P450 4F2\",\"id\":\"P78329\"}]", "uniprot_id": "[\"P04798\",\"P05177\",\"P10632\",\"P11712\",\"P33261\",\"P78329\",\"Q02928\",\"Q16678\",\"Q7Z449\"]", "gene_symbol": "[\"CYP1A1\",\"CYP1A2\",\"CYP1B1\",\"CYP2C10\",\"CYP2C19\",\"CYP2C8\",\"CYP2C9\",\"CYP2U1\",\"CYP4A11\",\"CYP4A2\",\"CYP4F2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Translation initiation complex formation", "protein_name": "[{\"label\":\"Eukaryotic initiation factor 4A-I\",\"id\":\"P60842\"},{\"label\":\"Eukaryotic initiation factor 4A-II\",\"id\":\"Q14240\"},{\"label\":\"Eukaryotic translation initiation factor 1A, X-chromosomal\",\"id\":\"P47813\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 1\",\"id\":\"P05198\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 2\",\"id\":\"P20042\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 3\",\"id\":\"P41091\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit A\",\"id\":\"Q14152\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit B\",\"id\":\"P55884\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit C\",\"id\":\"Q99613\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit D\",\"id\":\"O15371\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit E\",\"id\":\"P60228\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit F\",\"id\":\"O00303\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit G\",\"id\":\"O75821\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit H\",\"id\":\"O15372\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit I\",\"id\":\"Q13347\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit J\",\"id\":\"O75822\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit K\",\"id\":\"Q9UBQ5\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit L\",\"id\":\"Q9Y262\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit M\",\"id\":\"Q7L2H7\"},{\"label\":\"Eukaryotic translation initiation factor 4 gamma 1\",\"id\":\"Q04637\"},{\"label\":\"Eukaryotic translation initiation factor 4B\",\"id\":\"P23588\"},{\"label\":\"Eukaryotic translation initiation factor 4E\",\"id\":\"P06730\"},{\"label\":\"Eukaryotic translation initiation factor 4H\",\"id\":\"Q15056\"},{\"label\":\"Polyadenylate-binding protein 1\",\"id\":\"P11940\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Small ribosomal subunit protein eS10\",\"id\":\"P46783\"},{\"label\":\"Small ribosomal subunit protein eS12\",\"id\":\"P25398\"},{\"label\":\"Small ribosomal subunit protein eS17\",\"id\":\"P08708\"},{\"label\":\"Small ribosomal subunit protein eS19\",\"id\":\"P39019\"},{\"label\":\"Small ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS4, X isoform\",\"id\":\"P62701\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 1\",\"id\":\"P22090\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 2\",\"id\":\"Q8TD47\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein eS7\",\"id\":\"P62081\"},{\"label\":\"Small ribosomal subunit protein eS8\",\"id\":\"P62241\"},{\"label\":\"Small ribosomal subunit protein uS10\",\"id\":\"P60866\"},{\"label\":\"Small ribosomal subunit protein uS11\",\"id\":\"P62263\"},{\"label\":\"Small ribosomal subunit protein uS12\",\"id\":\"P62266\"},{\"label\":\"Small ribosomal subunit protein uS13\",\"id\":\"P62269\"},{\"label\":\"Small ribosomal subunit protein uS14\",\"id\":\"P62273\"},{\"label\":\"Small ribosomal subunit protein uS15\",\"id\":\"P62277\"},{\"label\":\"Small ribosomal subunit protein uS17\",\"id\":\"P62280\"},{\"label\":\"Small ribosomal subunit protein uS19\",\"id\":\"P62841\"},{\"label\":\"Small ribosomal subunit protein uS2\",\"id\":\"P08865\"},{\"label\":\"Small ribosomal subunit protein uS3\",\"id\":\"P23396\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small ribosomal subunit protein uS7\",\"id\":\"P46782\"},{\"label\":\"Small ribosomal subunit protein uS8\",\"id\":\"P62244\"},{\"label\":\"Small ribosomal subunit protein uS9\",\"id\":\"P62249\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Activation of gene expression by SREBF (SREBP)", "protein_name": "[{\"label\":\"3'-5' exoribonuclease HELZ2\",\"id\":\"Q9BYK8\"},{\"label\":\"7-dehydrocholesterol reductase\",\"id\":\"Q9UBM7\"},{\"label\":\"Acetyl-CoA carboxylase 1\",\"id\":\"Q13085\"},{\"label\":\"Acetyl-CoA carboxylase 2\",\"id\":\"O00763\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 9\",\"id\":\"Q3L8U1\"},{\"label\":\"Delta(14)-sterol reductase TM7SF2\",\"id\":\"O76062\"},{\"label\":\"Diphosphomevalonate decarboxylase\",\"id\":\"P53602\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Farnesyl pyrophosphate synthase\",\"id\":\"P14324\"},{\"label\":\"Fatty acid synthase\",\"id\":\"P49327\"},{\"label\":\"Geranylgeranyl pyrophosphate synthase\",\"id\":\"O95749\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 1, mitochondrial\",\"id\":\"Q9HCL2\"},{\"label\":\"Histone-arginine methyltransferase CARM1\",\"id\":\"Q86X55\"},{\"label\":\"Hydroxymethylglutaryl-CoA synthase, cytoplasmic\",\"id\":\"Q01581\"},{\"label\":\"Isopentenyl-diphosphate Delta-isomerase 1\",\"id\":\"Q13907\"},{\"label\":\"Lanosterol 14-alpha demethylase\",\"id\":\"Q16850\"},{\"label\":\"Lanosterol synthase\",\"id\":\"P48449\"},{\"label\":\"Lathosterol oxidase\",\"id\":\"O75845\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 1\",\"id\":\"Q15648\"},{\"label\":\"Metal regulatory transcription factor 1\",\"id\":\"Q14872\"},{\"label\":\"Mevalonate kinase\",\"id\":\"Q03426\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Nuclear receptor coactivator 6\",\"id\":\"Q14686\"},{\"label\":\"Nuclear transcription factor Y subunit alpha\",\"id\":\"P23511\"},{\"label\":\"Nuclear transcription factor Y subunit beta\",\"id\":\"P25208\"},{\"label\":\"Nuclear transcription factor Y subunit gamma\",\"id\":\"Q13952\"},{\"label\":\"Peroxisome proliferator-activated receptor alpha\",\"id\":\"Q07869\"},{\"label\":\"Phosphomevalonate kinase\",\"id\":\"Q15126\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3\",\"id\":\"Q6STE5\"},{\"label\":\"Squalene monooxygenase\",\"id\":\"Q14534\"},{\"label\":\"Squalene synthase\",\"id\":\"P37268\"},{\"label\":\"Stearoyl-CoA desaturase\",\"id\":\"O00767\"},{\"label\":\"Sterol regulatory element-binding protein 2\",\"id\":\"Q12772\"},{\"label\":\"Transcription factor Sp1\",\"id\":\"P08047\"},{\"label\":\"Trimethylguanosine synthase\",\"id\":\"Q96RS0\"},{\"label\":\"Very long chain fatty acid elongase 6\",\"id\":\"Q9H5J4\"}]", "uniprot_id": "[\"O00763\",\"O00767\",\"O60907\",\"O75845\",\"O76062\",\"O95749\",\"P08047\",\"P14324\",\"P19793\",\"P23511\",\"P25208\",\"P37268\",\"P48449\",\"P49327\",\"P53602\",\"Q01581\",\"Q03426\",\"Q07869\",\"Q12772\",\"Q13085\",\"Q13907\",\"Q13952\",\"Q14534\",\"Q14686\",\"Q14872\",\"Q15126\",\"Q15596\",\"Q15648\",\"Q15788\",\"Q16850\",\"Q3L8U1\",\"Q6STE5\",\"Q86X55\",\"Q92793\",\"Q96RS0\",\"Q9BYK8\",\"Q9BZK7\",\"Q9H5J4\",\"Q9HCL2\",\"Q9UBM7\"]", "gene_symbol": "[\"ACAC\",\"ACACA\",\"ACACB\",\"ACC1\",\"ACC2\",\"ACCA\",\"ACCB\",\"AIB3\",\"ANG1\",\"ARC205\",\"BAF60C\",\"BHLHD2\",\"BHLHE74\",\"BHLHE75\",\"CARM1\",\"CBP\",\"CHD9\",\"CREBBP\",\"CRSP1\",\"CRSP200\",\"CYP51\",\"CYP51A1\",\"D7SR\",\"DHCR7\",\"DRIP205\",\"DRIP230\",\"ELOVL6\",\"ERG1\",\"FACE\",\"FADS5\",\"FAS\",\"FASN\",\"FDFT1\",\"FDPS\",\"FPS\",\"GGPS1\",\"GPAM\",\"GPAT1\",\"HAP3\",\"HCA137\",\"HELZ2\",\"HMGCS\",\"HMGCS1\",\"IDI1\",\"IRA1\",\"KIAA0181\",\"KIAA0308\",\"KIAA1293\",\"KIAA1560\",\"KIAA1769\",\"KISH2\",\"LCE\",\"LSS\",\"MED1\",\"MPD\",\"MTF1\",\"MVD\",\"MVK\",\"NCOA1\",\"NCOA2\",\"NCOA6\",\"NCOA6IP\",\"NFYA\",\"NFYB\",\"NFYC\",\"NR1C1\",\"NR2B1\",\"OSC\",\"PBP\",\"PIMT\",\"PMKI\",\"PMVK\",\"PPAR\",\"PPARA\",\"PPARBP\",\"PPARGBP\",\"PRIC285\",\"PRIC320\",\"PRMT4\",\"RAP250\",\"RB18A\",\"RXRA\",\"SC5D\",\"SC5DL\",\"SCD\",\"SCD1\",\"SCDOS\",\"SMARCD3\",\"SP1\",\"SQLE\",\"SRC1\",\"SRC2\",\"SREBF2\",\"SREBP2\",\"TBL1\",\"TBL1X\",\"TBL1XR1\",\"TBLR1\",\"TGS1\",\"TIF2\",\"TM7SF2\",\"TRAP220\",\"TRBP\",\"TRIP2\",\"TSFP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ribosomal scanning and start codon recognition", "protein_name": "[{\"label\":\"Eukaryotic initiation factor 4A-I\",\"id\":\"P60842\"},{\"label\":\"Eukaryotic initiation factor 4A-II\",\"id\":\"Q14240\"},{\"label\":\"Eukaryotic translation initiation factor 1A, X-chromosomal\",\"id\":\"P47813\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 1\",\"id\":\"P05198\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 2\",\"id\":\"P20042\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 3\",\"id\":\"P41091\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit A\",\"id\":\"Q14152\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit B\",\"id\":\"P55884\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit C\",\"id\":\"Q99613\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit D\",\"id\":\"O15371\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit E\",\"id\":\"P60228\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit F\",\"id\":\"O00303\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit G\",\"id\":\"O75821\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit H\",\"id\":\"O15372\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit I\",\"id\":\"Q13347\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit J\",\"id\":\"O75822\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit K\",\"id\":\"Q9UBQ5\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit L\",\"id\":\"Q9Y262\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit M\",\"id\":\"Q7L2H7\"},{\"label\":\"Eukaryotic translation initiation factor 4 gamma 1\",\"id\":\"Q04637\"},{\"label\":\"Eukaryotic translation initiation factor 4B\",\"id\":\"P23588\"},{\"label\":\"Eukaryotic translation initiation factor 4E\",\"id\":\"P06730\"},{\"label\":\"Eukaryotic translation initiation factor 4H\",\"id\":\"Q15056\"},{\"label\":\"Eukaryotic translation initiation factor 5\",\"id\":\"P55010\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Small ribosomal subunit protein eS10\",\"id\":\"P46783\"},{\"label\":\"Small ribosomal subunit protein eS12\",\"id\":\"P25398\"},{\"label\":\"Small ribosomal subunit protein eS17\",\"id\":\"P08708\"},{\"label\":\"Small ribosomal subunit protein eS19\",\"id\":\"P39019\"},{\"label\":\"Small ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS4, X isoform\",\"id\":\"P62701\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 1\",\"id\":\"P22090\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 2\",\"id\":\"Q8TD47\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein eS7\",\"id\":\"P62081\"},{\"label\":\"Small ribosomal subunit protein eS8\",\"id\":\"P62241\"},{\"label\":\"Small ribosomal subunit protein uS10\",\"id\":\"P60866\"},{\"label\":\"Small ribosomal subunit protein uS11\",\"id\":\"P62263\"},{\"label\":\"Small ribosomal subunit protein uS12\",\"id\":\"P62266\"},{\"label\":\"Small ribosomal subunit protein uS13\",\"id\":\"P62269\"},{\"label\":\"Small ribosomal subunit protein uS14\",\"id\":\"P62273\"},{\"label\":\"Small ribosomal subunit protein uS15\",\"id\":\"P62277\"},{\"label\":\"Small ribosomal subunit protein uS17\",\"id\":\"P62280\"},{\"label\":\"Small ribosomal subunit protein uS19\",\"id\":\"P62841\"},{\"label\":\"Small ribosomal subunit protein uS2\",\"id\":\"P08865\"},{\"label\":\"Small ribosomal subunit protein uS3\",\"id\":\"P23396\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small ribosomal subunit protein uS7\",\"id\":\"P46782\"},{\"label\":\"Small ribosomal subunit protein uS8\",\"id\":\"P62244\"},{\"label\":\"Small ribosomal subunit protein uS9\",\"id\":\"P62249\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00303\",\"O15371\",\"O15372\",\"O75821\",\"O75822\",\"P05198\",\"P06730\",\"P08708\",\"P08865\",\"P15880\",\"P20042\",\"P22090\",\"P23396\",\"P23588\",\"P25398\",\"P39019\",\"P41091\",\"P42677\",\"P46781\",\"P46782\",\"P46783\",\"P47813\",\"P55010\",\"P55884\",\"P60228\",\"P60842\",\"P60866\",\"P61247\",\"P62081\",\"P62241\",\"P62244\",\"P62249\",\"P62263\",\"P62266\",\"P62269\",\"P62273\",\"P62277\",\"P62280\",\"P62701\",\"P62753\",\"P62841\",\"P62847\",\"P62851\",\"P62854\",\"P62857\",\"P62861\",\"P62979\",\"P63220\",\"Q04637\",\"Q13347\",\"Q14152\",\"Q14240\",\"Q15056\",\"Q71UM5\",\"Q7L2H7\",\"Q8TD47\",\"Q99613\",\"Q9UBQ5\",\"Q9Y262\"]", "gene_symbol": "[\"CCG2\",\"D6S218E\",\"DDX2A\",\"DDX2B\",\"EIF1A\",\"EIF1AX\",\"EIF2A\",\"EIF2B\",\"EIF2G\",\"EIF2S1\",\"EIF2S2\",\"EIF2S3\",\"EIF3A\",\"EIF3B\",\"EIF3C\",\"EIF3D\",\"EIF3E\",\"EIF3EIP\",\"EIF3F\",\"EIF3G\",\"EIF3H\",\"EIF3I\",\"EIF3J\",\"EIF3K\",\"EIF3L\",\"EIF3M\",\"EIF3S1\",\"EIF3S10\",\"EIF3S12\",\"EIF3S2\",\"EIF3S3\",\"EIF3S4\",\"EIF3S5\",\"EIF3S6\",\"EIF3S6IP\",\"EIF3S7\",\"EIF3S8\",\"EIF3S9\",\"EIF4A\",\"EIF4A1\",\"EIF4A2\",\"EIF4B\",\"EIF4C\",\"EIF4E\",\"EIF4EL1\",\"EIF4F\",\"EIF4G\",\"EIF4G1\",\"EIF4GI\",\"EIF4H\",\"EIF5\",\"FAU\",\"FTE1\",\"HFLB5\",\"INT6\",\"KIAA0038\",\"KIAA0139\",\"LAMBR\",\"LAMR1\",\"MFTL\",\"MPS1\",\"PCID1\",\"RIG\",\"RPS10\",\"RPS11\",\"RPS12\",\"RPS13\",\"RPS14\",\"RPS15\",\"RPS15A\",\"RPS16\",\"RPS17\",\"RPS17L\",\"RPS18\",\"RPS19\",\"RPS2\",\"RPS20\",\"RPS21\",\"RPS23\",\"RPS24\",\"RPS25\",\"RPS26\",\"RPS27\",\"RPS27A\",\"RPS27L\",\"RPS28\",\"RPS29\",\"RPS3\",\"RPS3A\",\"RPS4\",\"RPS4X\",\"RPS4Y\",\"RPS4Y1\",\"RPS4Y2\",\"RPS4Y2P\",\"RPS5\",\"RPS6\",\"RPS7\",\"RPS8\",\"RPS9\",\"RPSA\",\"SCAR\",\"TRIP1\",\"UBA80\",\"UBCEP1\",\"WBSCR1\",\"WSCR1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SUMO is proteolytically processed", "protein_name": "[{\"label\":\"Sentrin-specific protease 1\",\"id\":\"Q9P0U3\"},{\"label\":\"Sentrin-specific protease 2\",\"id\":\"Q9HC62\"},{\"label\":\"Sentrin-specific protease 5\",\"id\":\"Q96HI0\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"},{\"label\":\"Small ubiquitin-related modifier 2\",\"id\":\"P61956\"},{\"label\":\"Small ubiquitin-related modifier 3\",\"id\":\"P55854\"}]", "uniprot_id": "[\"P55854\",\"P61956\",\"P63165\",\"Q96HI0\",\"Q9HC62\",\"Q9P0U3\"]", "gene_symbol": "[\"KIAA1331\",\"SENP1\",\"SENP2\",\"SENP5\",\"SMT3A\",\"SMT3B\",\"SMT3C\",\"SMT3H1\",\"SMT3H2\",\"SMT3H3\",\"SUMO1\",\"SUMO2\",\"SUMO3\",\"UBL1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective CSF2RB causes SMDP5", "protein_name": "[{\"label\":\"Cytokine receptor common subunit beta\",\"id\":\"P32927\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor receptor subunit alpha\",\"id\":\"P15509\"},{\"label\":\"Pulmonary surfactant-associated protein A1\",\"id\":\"Q8IWL2\"},{\"label\":\"Pulmonary surfactant-associated protein A2\",\"id\":\"Q8IWL1\"},{\"label\":\"Pulmonary surfactant-associated protein B\",\"id\":\"P07988\"},{\"label\":\"Pulmonary surfactant-associated protein D\",\"id\":\"P35247\"},{\"label\":\"Surfactant protein C\",\"id\":\"P11686\"},{\"label\":\"Surfactant-associated protein 3\",\"id\":\"P0C7M3\"}]", "uniprot_id": "[\"P07988\",\"P0C7M3\",\"P11686\",\"P15509\",\"P32927\",\"P35247\",\"Q8IWL1\",\"Q8IWL2\"]", "gene_symbol": "[\"COLEC4\",\"COLEC5\",\"COLEC7\",\"CSF2R\",\"CSF2RA\",\"CSF2RB\",\"CSF2RY\",\"IL3RB\",\"IL5RB\",\"PSAP\",\"PSPD\",\"SFTA3\",\"SFTP1\",\"SFTP2\",\"SFTP3\",\"SFTP4\",\"SFTPA\",\"SFTPA1\",\"SFTPA1B\",\"SFTPA2\",\"SFTPA2B\",\"SFTPB\",\"SFTPC\",\"SFTPD\",\"SFTPH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Glucokinase regulatory protein\",\"id\":\"Q14397\"},{\"label\":\"Hexokinase-4\",\"id\":\"P35557\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": 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"pathway_label": "Regulation of NF-kappa B signaling", "protein_name": "[{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase-interacting protein\",\"id\":\"Q70UQ0\"},{\"label\":\"Leucine-rich repeat-containing protein 14\",\"id\":\"Q15048\"},{\"label\":\"NEDD4-binding protein 1\",\"id\":\"O75113\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"NLR family member X1\",\"id\":\"Q86UT6\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein NLRC5\",\"id\":\"Q86WI3\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 14\",\"id\":\"P54578\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Ubl carboxyl-terminal hydrolase 18\",\"id\":\"Q9UMW8\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"O75113\",\"P04637\",\"P0CG47\",\"P0CG48\",\"P54578\",\"P62979\",\"P62987\",\"Q12933\",\"Q14790\",\"Q15048\",\"Q70UQ0\",\"Q86UT6\",\"Q86WI3\",\"Q9UMW8\",\"Q9Y4K3\",\"Q9Y6K9\"]", "gene_symbol": "[\"CASP8\",\"CHUK\",\"FIP3\",\"IKBIP\",\"IKBKB\",\"IKBKG\",\"IKIP\",\"IKKA\",\"IKKB\",\"ISG43\",\"KIAA0014\",\"KIAA0615\",\"LRRC14\",\"MCH5\",\"N4BP1\",\"NEMO\",\"NLRC5\",\"NLRX1\",\"NOD27\",\"NOD4\",\"NOD5\",\"NOD9\",\"P53\",\"RNF85\",\"RPS27A\",\"TCF16\",\"TGT\",\"TP53\",\"TRAF2\",\"TRAF6\",\"TRAP3\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"USP14\",\"USP18\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Aberrant regulation of mitotic exit in cancer due to RB1 defects", "protein_name": "[{\"label\":\"Anaphase-promoting complex subunit 10\",\"id\":\"Q9UM13\"},{\"label\":\"Anaphase-promoting complex subunit 11\",\"id\":\"Q9NYG5\"},{\"label\":\"Anaphase-promoting complex subunit 15\",\"id\":\"P60006\"},{\"label\":\"Anaphase-promoting complex subunit 16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 5\",\"id\":\"Q9UJX4\"},{\"label\":\"Anaphase-promoting complex subunit 7\",\"id\":\"Q9UJX3\"},{\"label\":\"Anaphase-promoting complex subunit CDC26\",\"id\":\"Q8NHZ8\"},{\"label\":\"Cell division cycle protein 16 homolog\",\"id\":\"Q13042\"},{\"label\":\"Cell division cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"S-phase kinase-associated protein 2\",\"id\":\"Q13309\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"}]", "uniprot_id": "[\"O00762\",\"P06400\",\"P30260\",\"P51668\",\"P51965\",\"P60006\",\"Q13042\",\"Q13309\",\"Q16763\",\"Q8NHZ8\",\"Q96DE5\",\"Q9H1A4\",\"Q9NYG5\",\"Q9UJX2\",\"Q9UJX3\",\"Q9UJX4\",\"Q9UJX5\",\"Q9UJX6\",\"Q9UM11\",\"Q9UM13\"]", "gene_symbol": 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"[\"A2BP\",\"A2BP1\",\"FOX1\",\"HRNBP1\",\"MEF2C\",\"NR1C3\",\"PPARG\",\"RBFOX1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Asymmetric localization of PCP proteins", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"E3 ubiquitin-protein ligase SMURF1\",\"id\":\"Q9HCE7\"},{\"label\":\"E3 ubiquitin-protein ligase SMURF2\",\"id\":\"Q9HAU4\"},{\"label\":\"Frizzled-1\",\"id\":\"Q9UP38\"},{\"label\":\"Frizzled-2\",\"id\":\"Q14332\"},{\"label\":\"Frizzled-3\",\"id\":\"Q9NPG1\"},{\"label\":\"Frizzled-4\",\"id\":\"Q9ULV1\"},{\"label\":\"Frizzled-5\",\"id\":\"Q13467\"},{\"label\":\"Frizzled-7\",\"id\":\"O75084\"},{\"label\":\"Frizzled-8\",\"id\":\"Q9H461\"},{\"label\":\"Partitioning defective 6 homolog alpha\",\"id\":\"Q9NPB6\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Prickle-like protein 1\",\"id\":\"Q96MT3\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Protein scribble homolog\",\"id\":\"Q14160\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-2\",\"id\":\"O14641\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Vang-like protein 2\",\"id\":\"Q9ULK5\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "MPS IIIC - Sanfilippo syndrome C", "protein_name": "[{\"label\":\"Heparan-alpha-glucosaminide N-acetyltransferase\",\"id\":\"Q68CP4\"}]", "uniprot_id": "[\"Q68CP4\"]", "gene_symbol": "[\"HGSNAT\",\"TMEM76\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Vpu mediated degradation of CD4", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"T-cell surface glycoprotein CD4\",\"id\":\"P01730\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00231\",\"O00232\",\"O00487\",\"O14818\",\"O43242\",\"P01730\",\"P05919\",\"P0CG47\",\"P0CG48\",\"P17980\",\"P20618\",\"P25786\",\"P25787\",\"P25788\",\"P25789\",\"P28066\",\"P28070\",\"P28072\",\"P28074\",\"P35998\",\"P43686\",\"P48556\",\"P49720\",\"P49721\",\"P51665\",\"P60896\",\"P60900\",\"P62191\",\"P62195\",\"P62333\",\"P62979\",\"P62987\",\"P63208\",\"Q13200\",\"Q15008\",\"Q16186\",\"Q99436\",\"Q99460\",\"Q9UNM6\",\"Q9Y297\"]", "gene_symbol": 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Kit\",\"id\":\"P10721\"}]", "uniprot_id": "[\"P10721\"]", "gene_symbol": "[\"KIT\",\"SCFR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transport of inorganic cations/anions and amino acids/oligopeptides", "protein_name": "[{\"label\":\"Cystinosin\",\"id\":\"O60931\"},{\"label\":\"Excitatory amino acid transporter 1\",\"id\":\"P43003\"},{\"label\":\"Excitatory amino acid transporter 2\",\"id\":\"P43004\"},{\"label\":\"Excitatory amino acid transporter 3\",\"id\":\"P43005\"},{\"label\":\"Excitatory amino acid transporter 4\",\"id\":\"P48664\"},{\"label\":\"Excitatory amino acid transporter 5\",\"id\":\"O00341\"},{\"label\":\"Mitochondrial S-adenosylmethionine carrier protein\",\"id\":\"Q70HW3\"},{\"label\":\"Vesicular inhibitory amino acid transporter\",\"id\":\"Q9H598\"}]", "uniprot_id": "[\"O00341\",\"O60931\",\"P43003\",\"P43004\",\"P43005\",\"P48664\",\"Q70HW3\",\"Q9H598\"]", "gene_symbol": "[\"CTNS\",\"EAAC1\",\"EAAT1\",\"EAAT2\",\"EAAT3\",\"EAAT4\",\"EAAT5\",\"GLAST\",\"GLAST1\",\"GLT1\",\"HEAAC1\",\"SAMC\",\"SLC1A1\",\"SLC1A2\",\"SLC1A3\",\"SLC1A6\",\"SLC1A7\",\"SLC25A26\",\"SLC32A1\",\"VGAT\",\"VIAAT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Breakdown of the nuclear lamina", "protein_name": "[{\"label\":\"Caspase-6\",\"id\":\"P55212\"},{\"label\":\"Lamin-B1\",\"id\":\"P20700\"}]", "uniprot_id": "[\"P20700\",\"P55212\"]", "gene_symbol": "[\"CASP6\",\"LMN2\",\"LMNB\",\"LMNB1\",\"MCH2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Choline catabolism", "protein_name": "[{\"label\":\"Alpha-aminoadipic semialdehyde dehydrogenase\",\"id\":\"P49419\"},{\"label\":\"Betaine--homocysteine S-methyltransferase 1\",\"id\":\"Q93088\"},{\"label\":\"Choline dehydrogenase, mitochondrial\",\"id\":\"Q8NE62\"},{\"label\":\"Choline transporter-like protein 1\",\"id\":\"Q8WWI5\"},{\"label\":\"Dimethylglycine dehydrogenase, mitochondrial\",\"id\":\"Q9UI17\"},{\"label\":\"Sarcosine dehydrogenase, mitochondrial\",\"id\":\"Q9UL12\"}]", "uniprot_id": "[\"P49419\",\"Q8NE62\",\"Q8WWI5\",\"Q93088\",\"Q9UI17\",\"Q9UL12\"]", "gene_symbol": "[\"ALDH7A1\",\"ATQ1\",\"BHMT\",\"CD92\",\"CDW92\",\"CHDH\",\"CTL1\",\"DMGDH\",\"DMGDHL1\",\"SARDH\",\"SLC44A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MET activates RAP1 and RAC1", "protein_name": "[{\"label\":\"Adapter molecule crk\",\"id\":\"P46108\"},{\"label\":\"Crk-like protein\",\"id\":\"P46109\"},{\"label\":\"Dedicator of cytokinesis protein 7\",\"id\":\"Q96N67\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"Hepatocyte growth factor receptor\",\"id\":\"P08581\"},{\"label\":\"Hepatocyte growth factor\",\"id\":\"P14210\"},{\"label\":\"Rap guanine nucleotide exchange factor 1\",\"id\":\"Q13905\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"}]", "uniprot_id": "[\"P08581\",\"P14210\",\"P46108\",\"P46109\",\"P61224\",\"P62834\",\"P63000\",\"Q13480\",\"Q13905\",\"Q96N67\"]", "gene_symbol": "[\"CRK\",\"CRKL\",\"DOCK7\",\"GAB1\",\"GRF2\",\"HGF\",\"HPTA\",\"KIAA1771\",\"KREV1\",\"MET\",\"RAC1\",\"RAP1A\",\"RAP1B\",\"RAPGEF1\",\"TC25\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transport of the SLBP Dependant Mature mRNA", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Eukaryotic translation initiation factor 4E\",\"id\":\"P06730\"},{\"label\":\"Histone RNA hairpin-binding protein\",\"id\":\"Q14493\"},{\"label\":\"Nuclear RNA export factor 1\",\"id\":\"Q9UBU9\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"THO complex subunit 4\",\"id\":\"Q86V81\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": "[\"A8CG34\",\"O15504\",\"O75694\",\"P06730\",\"P12270\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P52298\",\"P55735\",\"P57740\",\"P78406\",\"Q09161\",\"Q12769\",\"Q14493\",\"Q5SRE5\",\"Q7Z3B4\",\"Q86V81\",\"Q8N1F7\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q96HA1\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9NRG9\",\"Q9UBU9\",\"Q9UKX7\"]", "gene_symbol": 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protein 2\",\"id\":\"Q6P589\"},{\"label\":\"Tumor necrosis factor alpha-induced protein 8-like protein 3\",\"id\":\"Q5GJ75\"},{\"label\":\"Tumor necrosis factor alpha-induced protein 8\",\"id\":\"O95379\"}]", "uniprot_id": "[\"O95379\",\"Q5GJ75\",\"Q6P589\",\"Q8WVP5\"]", "gene_symbol": "[\"TIPE3\",\"TNFAIP8\",\"TNFAIP8L1\",\"TNFAIP8L2\",\"TNFAIP8L3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of the ureteric bud", "protein_name": "[{\"label\":\"Bone morphogenetic protein 4\",\"id\":\"P12644\"},{\"label\":\"Eyes absent homolog 1\",\"id\":\"Q99502\"},{\"label\":\"Forkhead box protein C1\",\"id\":\"Q12948\"},{\"label\":\"Forkhead box protein C2\",\"id\":\"Q99958\"},{\"label\":\"GDNF family receptor alpha-1\",\"id\":\"P56159\"},{\"label\":\"Glial cell line-derived neurotrophic factor\",\"id\":\"P39905\"},{\"label\":\"Gremlin-1\",\"id\":\"O60565\"},{\"label\":\"Homeobox protein Hox-A11\",\"id\":\"P31270\"},{\"label\":\"Homeobox protein Hox-C11\",\"id\":\"O43248\"},{\"label\":\"Homeobox protein Hox-D11\",\"id\":\"P31277\"},{\"label\":\"Homeobox protein SIX1\",\"id\":\"Q15475\"},{\"label\":\"Homeobox protein SIX2\",\"id\":\"Q9NPC8\"},{\"label\":\"Integrin alpha-8\",\"id\":\"P53708\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Nephronectin\",\"id\":\"Q6UXI9\"},{\"label\":\"Paired box protein Pax-2\",\"id\":\"Q02962\"},{\"label\":\"Protein Wnt-11\",\"id\":\"O96014\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase receptor Ret\",\"id\":\"P07949\"},{\"label\":\"Roundabout homolog 2\",\"id\":\"Q9HCK4\"},{\"label\":\"Sal-like protein 1\",\"id\":\"Q9NSC2\"},{\"label\":\"Slit homolog 2 protein\",\"id\":\"O94813\"}]", "uniprot_id": "[\"O43248\",\"O60565\",\"O94813\",\"O96014\",\"P05556\",\"P07949\",\"P12644\",\"P31270\",\"P31277\",\"P39905\",\"P53708\",\"P56159\",\"Q02962\",\"Q12948\",\"Q15475\",\"Q6UXI9\",\"Q99502\",\"Q99958\",\"Q9HCK4\",\"Q9NPC8\",\"Q9NSC2\"]", "gene_symbol": "[\"BMP2B\",\"BMP4\",\"CDHF12\",\"CDHR16\",\"CKTSF1B1\",\"DAND2\",\"DRM\",\"DVR4\",\"EGFL6L\",\"EYA1\",\"FKHL14\",\"FKHL7\",\"FNRB\",\"FOXC1\",\"FOXC2\",\"FREAC3\",\"GDNF\",\"GDNFRA\",\"GFRA1\",\"GREM1\",\"HOX1I\",\"HOX3H\",\"HOX4F\",\"HOXA11\",\"HOXC11\",\"HOXD11\",\"ITGA8\",\"ITGB1\",\"KIAA1568\",\"MDF2\",\"MFH1\",\"MSK12\",\"NPNT\",\"PAX2\",\"POEM\",\"PTC\",\"RET\",\"RETL1\",\"ROBO2\",\"SAL1\",\"SALL1\",\"SIX1\",\"SIX2\",\"SLIL3\",\"SLIT2\",\"TRNR1\",\"WNT11\",\"ZNF794\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Striated Muscle Contraction", "protein_name": "[{\"label\":\"Alpha-actinin-2\",\"id\":\"P35609\"},{\"label\":\"Alpha-actinin-3\",\"id\":\"Q08043\"},{\"label\":\"Desmin\",\"id\":\"P17661\"},{\"label\":\"Dystrophin\",\"id\":\"P11532\"},{\"label\":\"Myosin light chain 1/3, skeletal muscle isoform\",\"id\":\"P05976\"},{\"label\":\"Myosin light chain 3\",\"id\":\"P08590\"},{\"label\":\"Myosin light chain 4\",\"id\":\"P12829\"},{\"label\":\"Myosin regulatory light chain 2, ventricular/cardiac muscle isoform\",\"id\":\"P10916\"},{\"label\":\"Myosin-3\",\"id\":\"P11055\"},{\"label\":\"Myosin-6\",\"id\":\"P13533\"},{\"label\":\"Myosin-8\",\"id\":\"P13535\"},{\"label\":\"Myosin-binding protein C, cardiac-type\",\"id\":\"Q14896\"},{\"label\":\"Myosin-binding protein C, fast-type\",\"id\":\"Q14324\"},{\"label\":\"Myosin-binding protein C, slow-type\",\"id\":\"Q00872\"},{\"label\":\"Nebulin\",\"id\":\"P20929\"},{\"label\":\"Telethonin\",\"id\":\"O15273\"},{\"label\":\"Titin\",\"id\":\"Q8WZ42\"},{\"label\":\"Tropomodulin-1\",\"id\":\"P28289\"},{\"label\":\"Tropomodulin-2\",\"id\":\"Q9NZR1\"},{\"label\":\"Tropomodulin-3\",\"id\":\"Q9NYL9\"},{\"label\":\"Tropomodulin-4\",\"id\":\"Q9NZQ9\"},{\"label\":\"Tropomyosin alpha-1 chain\",\"id\":\"P09493\"},{\"label\":\"Tropomyosin alpha-3 chain\",\"id\":\"P06753\"},{\"label\":\"Tropomyosin alpha-4 chain\",\"id\":\"P67936\"},{\"label\":\"Tropomyosin beta chain\",\"id\":\"P07951\"},{\"label\":\"Troponin C, skeletal muscle\",\"id\":\"P02585\"},{\"label\":\"Troponin C, slow skeletal and cardiac muscles\",\"id\":\"P63316\"},{\"label\":\"Troponin I, cardiac muscle\",\"id\":\"P19429\"},{\"label\":\"Troponin I, fast skeletal muscle\",\"id\":\"P48788\"},{\"label\":\"Troponin I, slow skeletal muscle\",\"id\":\"P19237\"},{\"label\":\"Troponin T, cardiac muscle\",\"id\":\"P45379\"},{\"label\":\"Troponin T, fast skeletal muscle\",\"id\":\"P45378\"},{\"label\":\"Troponin T, slow skeletal muscle\",\"id\":\"P13805\"},{\"label\":\"Vimentin\",\"id\":\"P08670\"}]", "uniprot_id": "[\"O15273\",\"P02585\",\"P05976\",\"P06753\",\"P07951\",\"P08590\",\"P08670\",\"P09493\",\"P10916\",\"P11055\",\"P11532\",\"P12829\",\"P13533\",\"P13535\",\"P13805\",\"P17661\",\"P19237\",\"P19429\",\"P20929\",\"P28289\",\"P35609\",\"P45378\",\"P45379\",\"P48788\",\"P63316\",\"P67936\",\"Q00872\",\"Q08043\",\"Q14324\",\"Q14896\",\"Q8WZ42\",\"Q9NYL9\",\"Q9NZQ9\",\"Q9NZR1\"]", "gene_symbol": "[\"ACTN2\",\"ACTN3\",\"C15orf13\",\"D9S57E\",\"DES\",\"DMD\",\"MLC1\",\"MLC2\",\"MYBPC1\",\"MYBPC2\",\"MYBPC3\",\"MYBPCF\",\"MYBPCS\",\"MYH3\",\"MYH6\",\"MYH8\",\"MYHCA\",\"MYL1\",\"MYL2\",\"MYL3\",\"MYL4\",\"NEB\",\"NTMOD\",\"TCAP\",\"TMOD\",\"TMOD1\",\"TMOD2\",\"TMOD3\",\"TMOD4\",\"TMSA\",\"TMSB\",\"TNNC\",\"TNNC1\",\"TNNC2\",\"TNNI1\",\"TNNI2\",\"TNNI3\",\"TNNT1\",\"TNNT2\",\"TNNT3\",\"TNT\",\"TPM1\",\"TPM2\",\"TPM3\",\"TPM4\",\"TTN\",\"VIM\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Chylomicron clearance", "protein_name": "[{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Apolipoprotein E\",\"id\":\"P02649\"},{\"label\":\"Hepatic triacylglycerol lipase\",\"id\":\"P11150\"},{\"label\":\"Low density lipoprotein receptor adapter protein 1\",\"id\":\"Q5SW96\"},{\"label\":\"Low-density lipoprotein receptor\",\"id\":\"P01130\"}]", "uniprot_id": "[\"P01130\",\"P02649\",\"P04114\",\"P11150\",\"Q5SW96\"]", "gene_symbol": "[\"APOB\",\"APOE\",\"ARH\",\"HTGL\",\"LDLR\",\"LDLRAP1\",\"LIPC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by RAS GTPase mutants", "protein_name": "[{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase KRas\",\"id\":\"P01116\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P01116\"]", "gene_symbol": "[\"HRAS\",\"HRAS1\",\"KRAS\",\"KRAS2\",\"NRAS\",\"RASK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by activated point mutants of FGFR1", "protein_name": "[{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 1\",\"id\":\"P11362\"}]", "uniprot_id": "[\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11362\",\"P31371\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": "[\"BFGFR\",\"CEK\",\"FGF1\",\"FGF2\",\"FGF20\",\"FGF23\",\"FGF4\",\"FGF6\",\"FGF9\",\"FGFA\",\"FGFB\",\"FGFBR\",\"FGFR1\",\"FLG\",\"FLT2\",\"HBGFR\",\"HST\",\"HST2\",\"HSTF1\",\"HSTF2\",\"HYPF\",\"KS3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Toxicity of botulinum toxin type C (botC)", "protein_name": "[{\"label\":\"Botulinum neurotoxin type C\",\"id\":\"P18640\"},{\"label\":\"Synaptosomal-associated protein 25\",\"id\":\"P60880\"},{\"label\":\"Syntaxin-1A\",\"id\":\"Q16623\"},{\"label\":\"Syntaxin-1B\",\"id\":\"P61266\"}]", "uniprot_id": "[\"P18640\",\"P60880\",\"P61266\",\"Q16623\"]", "gene_symbol": "[\"SNAP\",\"SNAP25\",\"STX1\",\"STX1A\",\"STX1B\",\"STX1B1\",\"STX1B2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HIV elongation arrest and recovery", "protein_name": "[{\"label\":\"Cyclin-K\",\"id\":\"O75909\"},{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-T2\",\"id\":\"O60583\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Elongin-A2\",\"id\":\"Q8IYF1\"},{\"label\":\"Elongin-A\",\"id\":\"Q14241\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"FACT complex subunit SPT16\",\"id\":\"Q9Y5B9\"},{\"label\":\"FACT complex subunit SSRP1\",\"id\":\"Q08945\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"Negative elongation factor A\",\"id\":\"Q9H3P2\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"},{\"label\":\"Negative elongation factor C/D\",\"id\":\"Q8IXH7\"},{\"label\":\"Negative elongation factor E\",\"id\":\"P18615\"},{\"label\":\"RNA polymerase II elongation factor ELL\",\"id\":\"P55199\"},{\"label\":\"RNA polymerase II subunit A C-terminal domain phosphatase\",\"id\":\"Q9Y5B0\"},{\"label\":\"Transcription elongation factor A protein 1\",\"id\":\"P23193\"},{\"label\":\"Transcription elongation factor SPT4\",\"id\":\"P63272\"},{\"label\":\"Transcription elongation factor SPT5\",\"id\":\"O00267\"}]", "uniprot_id": "[\"O00267\",\"O15514\",\"O60563\",\"O60583\",\"O75909\",\"P13984\",\"P18615\",\"P19387\",\"P19388\",\"P23193\",\"P24928\",\"P30876\",\"P35269\",\"P36954\",\"P50750\",\"P52434\",\"P52435\",\"P53803\",\"P55199\",\"P61218\",\"P62487\",\"P62875\",\"P63272\",\"Q08945\",\"Q14241\",\"Q15369\",\"Q15370\",\"Q8IXH7\",\"Q8IYF1\",\"Q8WX92\",\"Q9H3P2\",\"Q9Y5B0\",\"Q9Y5B9\"]", "gene_symbol": "[\"C19orf17\",\"CCNK\",\"CCNT1\",\"CCNT2\",\"CDC2L4\",\"CDK9\",\"COBRA1\",\"CPR4\",\"CTDP1\",\"ELL\",\"ELOA\",\"ELOA2\",\"ELOB\",\"ELOC\",\"FACT140\",\"FACT80\",\"FACTP140\",\"FCP1\",\"GTF2F1\",\"GTF2F2\",\"GTF2S\",\"KIAA1182\",\"NELFA\",\"NELFB\",\"NELFCD\",\"NELFD\",\"NELFE\",\"POLR2\",\"POLR2A\",\"POLR2B\",\"POLR2C\",\"POLR2D\",\"POLR2E\",\"POLR2F\",\"POLR2G\",\"POLR2H\",\"POLR2I\",\"POLR2J\",\"POLR2J1\",\"POLR2K\",\"POLR2L\",\"POLRF\",\"RAP30\",\"RAP74\",\"RD\",\"RDBP\",\"RPB7\",\"SPT4H\",\"SPT5\",\"SPT5H\",\"SSRP1\",\"SUPT16H\",\"SUPT4H\",\"SUPT4H1\",\"SUPT5H\",\"TAK\",\"TCEA1\",\"TCEB1\",\"TCEB2\",\"TCEB3\",\"TCEB3B\",\"TCEB3L\",\"TFIIS\",\"TH1\",\"TH1L\",\"WHSC2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Unblocking of NMDA receptors, glutamate binding and activation", "protein_name": "[{\"label\":\"Alpha-actinin-2\",\"id\":\"P35609\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Disks large homolog 1\",\"id\":\"Q12959\"},{\"label\":\"Disks large homolog 2\",\"id\":\"Q15700\"},{\"label\":\"Disks large homolog 3\",\"id\":\"Q92796\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Glutamate receptor 1\",\"id\":\"P42261\"},{\"label\":\"Glutamate receptor 2\",\"id\":\"P42262\"},{\"label\":\"Glutamate receptor 3\",\"id\":\"P42263\"},{\"label\":\"Glutamate receptor 4\",\"id\":\"P48058\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 1\",\"id\":\"Q05586\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2A\",\"id\":\"Q12879\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Glutamate receptor 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2\",\"id\":\"O75886\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O14964\",\"O75886\",\"P08581\",\"P0CG47\",\"P0CG48\",\"P0DQD2\",\"P0DQD3\",\"P22681\",\"P42566\",\"P62979\",\"P62987\",\"Q92783\",\"Q96B97\",\"Q99961\",\"Q99962\",\"Q99963\"]", "gene_symbol": "[\"AF1P\",\"CBL\",\"CBL2\",\"CIN85\",\"CNSA1\",\"CNSA2\",\"CNSA3\",\"EPS15\",\"HBP\",\"HGS\",\"HRS\",\"MET\",\"RNF55\",\"RPS27A\",\"SH3D2A\",\"SH3D2B\",\"SH3D2C\",\"SH3GL1\",\"SH3GL2\",\"SH3GL3\",\"SH3KBP1\",\"STAM\",\"STAM1\",\"STAM2\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"inlB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Serotonin and melatonin biosynthesis", "protein_name": "[{\"label\":\"Acetylserotonin O-methyltransferase\",\"id\":\"P46597\"},{\"label\":\"Aromatic-L-amino-acid decarboxylase\",\"id\":\"P20711\"},{\"label\":\"Serotonin N-acetyltransferase\",\"id\":\"Q16613\"},{\"label\":\"Tryptophan 5-hydroxylase 1\",\"id\":\"P17752\"},{\"label\":\"Tryptophan 5-hydroxylase 2\",\"id\":\"Q8IWU9\"}]", "uniprot_id": "[\"P17752\",\"P20711\",\"P46597\",\"Q16613\",\"Q8IWU9\"]", "gene_symbol": "[\"AADC\",\"AANAT\",\"ASMT\",\"DDC\",\"NTPH\",\"SNAT\",\"TPH\",\"TPH1\",\"TPH2\",\"TPRH\",\"TRPH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RPIA deficiency: failed conversion of RU5P to R5P", "protein_name": "[{\"label\":\"Ribose-5-phosphate isomerase\",\"id\":\"P49247\"}]", "uniprot_id": "[\"P49247\"]", "gene_symbol": "[\"RPI\",\"RPIA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TP53 Regulates Transcription of Death Receptors and Ligands", "protein_name": "[{\"label\":\"Apoptosis-stimulating of p53 protein 1\",\"id\":\"Q96KQ4\"},{\"label\":\"Apoptosis-stimulating of p53 protein 2\",\"id\":\"Q13625\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Insulin-like growth factor-binding protein 3 receptor\",\"id\":\"Q86XT9\"},{\"label\":\"Insulin-like growth factor-binding protein 3\",\"id\":\"P17936\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10A\",\"id\":\"O00220\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10B\",\"id\":\"O14763\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10C\",\"id\":\"O14798\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10D\",\"id\":\"Q9UBN6\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 6\",\"id\":\"P25445\"},{\"label\":\"Tumor protein 63\",\"id\":\"Q9H3D4\"},{\"label\":\"Tumor protein p73\",\"id\":\"O15350\"}]", "uniprot_id": "[\"O00220\",\"O14763\",\"O14798\",\"O15350\",\"P04637\",\"P17936\",\"P25445\",\"Q13625\",\"Q86XT9\",\"Q96KQ4\",\"Q9H3D4\",\"Q9UBN6\"]", "gene_symbol": 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RAD9B\",\"id\":\"Q6WBX8\"},{\"label\":\"Cell cycle checkpoint protein RAD17\",\"id\":\"O75943\"},{\"label\":\"Cell cycle checkpoint protein RAD1\",\"id\":\"O60671\"},{\"label\":\"Checkpoint protein HUS1\",\"id\":\"O60921\"},{\"label\":\"DNA endonuclease RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA excision repair protein ERCC-1\",\"id\":\"P07992\"},{\"label\":\"DNA repair endonuclease XPF\",\"id\":\"Q92889\"},{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA repair protein RAD51 homolog 1\",\"id\":\"Q06609\"},{\"label\":\"DNA repair protein RAD52 homolog\",\"id\":\"P43351\"},{\"label\":\"DNA replication ATP-dependent helicase/nuclease DNA2\",\"id\":\"P51530\"},{\"label\":\"DNA topoisomerase 2-binding protein 1\",\"id\":\"Q92547\"},{\"label\":\"DNA topoisomerase 3-alpha\",\"id\":\"Q13472\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Exonuclease 1\",\"id\":\"Q9UQ84\"},{\"label\":\"Fanconi anemia group J protein\",\"id\":\"Q9BX63\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"RAD9, HUS1, RAD1-interacting nuclear orphan protein 1\",\"id\":\"Q9BSD3\"},{\"label\":\"RecQ-like DNA helicase BLM\",\"id\":\"P54132\"},{\"label\":\"RecQ-mediated genome instability protein 1\",\"id\":\"Q9H9A7\"},{\"label\":\"RecQ-mediated genome instability protein 2\",\"id\":\"Q96E14\"},{\"label\":\"Replication factor C subunit 2\",\"id\":\"P35250\"},{\"label\":\"Replication factor C subunit 3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"Serine/threonine-protein kinase ATR\",\"id\":\"Q13535\"},{\"label\":\"Tyrosine-protein kinase ABL1\",\"id\":\"P00519\"}]", "uniprot_id": "[\"O60671\",\"O60921\",\"O60934\",\"O75943\",\"P00519\",\"P07992\",\"P15927\",\"P27694\",\"P35244\",\"P35249\",\"P35250\",\"P38398\",\"P40937\",\"P40938\",\"P43351\",\"P49959\",\"P51530\",\"P54132\",\"Q06609\",\"Q13315\",\"Q13472\",\"Q13535\",\"Q14191\",\"Q6WBX8\",\"Q8WXE1\",\"Q92547\",\"Q92878\",\"Q92889\",\"Q92993\",\"Q96E14\",\"Q99638\",\"Q99708\",\"Q99728\",\"Q9BSD3\",\"Q9BX63\",\"Q9H9A7\",\"Q9UQ84\"]", "gene_symbol": "[\"ABL\",\"ABL1\",\"AGS1\",\"ATM\",\"ATR\",\"ATRIP\",\"BACH1\",\"BARD1\",\"BLM\",\"BRCA1\",\"BRIP1\",\"C12orf32\",\"C16orf75\",\"C9orf76\",\"CTIP\",\"DNA2\",\"DNA2L\",\"ERCC1\",\"ERCC11\",\"ERCC4\",\"EXO1\",\"EXOI\",\"FANCJ\",\"FRP1\",\"HEX1\",\"HNGS1\",\"HTATIP\",\"HUS1\",\"JTK7\",\"KAT5\",\"KIAA0083\",\"KIAA0259\",\"MRE11\",\"MRE11A\",\"NBN\",\"NBS\",\"NBS1\",\"P95\",\"R24L\",\"RAD1\",\"RAD17\",\"RAD50\",\"RAD51\",\"RAD51A\",\"RAD52\",\"RAD9A\",\"RAD9B\",\"RBBP8\",\"REC1\",\"RECA\",\"RECQ2\",\"RECQ3\",\"RECQL2\",\"RECQL3\",\"REPA1\",\"REPA2\",\"REPA3\",\"RFC2\",\"RFC3\",\"RFC4\",\"RFC5\",\"RHINO\",\"RHNO1\",\"RMI1\",\"RMI2\",\"RNF53\",\"RPA1\",\"RPA14\",\"RPA2\",\"RPA3\",\"RPA32\",\"RPA34\",\"RPA70\",\"TIP60\",\"TOP3\",\"TOP3A\",\"TOPBP1\",\"WRN\",\"XPF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC6A19 causes Hartnup disorder (HND)", "protein_name": "[{\"label\":\"Sodium-dependent neutral amino acid transporter B(0)AT1\",\"id\":\"Q695T7\"}]", "uniprot_id": "[\"Q695T7\"]", "gene_symbol": "[\"B0AT1\",\"SLC6A19\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HDR through Homologous Recombination (HRR)", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"BRCA1-associated RING domain protein 1\",\"id\":\"Q99728\"},{\"label\":\"Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN\",\"id\":\"Q14191\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"},{\"label\":\"Breast cancer type 2 susceptibility protein\",\"id\":\"P51587\"},{\"label\":\"DNA endonuclease RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA polymerase delta catalytic subunit\",\"id\":\"P28340\"},{\"label\":\"DNA polymerase delta subunit 2\",\"id\":\"P49005\"},{\"label\":\"DNA polymerase delta subunit 3\",\"id\":\"Q15054\"},{\"label\":\"DNA polymerase delta subunit 4\",\"id\":\"Q9HCU8\"},{\"label\":\"DNA polymerase epsilon catalytic subunit A\",\"id\":\"Q07864\"},{\"label\":\"DNA polymerase epsilon subunit 2\",\"id\":\"P56282\"},{\"label\":\"DNA polymerase epsilon subunit 3\",\"id\":\"Q9NRF9\"},{\"label\":\"DNA polymerase epsilon subunit 4\",\"id\":\"Q9NR33\"},{\"label\":\"DNA polymerase eta\",\"id\":\"Q9Y253\"},{\"label\":\"DNA polymerase kappa\",\"id\":\"Q9UBT6\"},{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA repair protein RAD51 homolog 1\",\"id\":\"Q06609\"},{\"label\":\"DNA repair protein RAD51 homolog 2\",\"id\":\"O15315\"},{\"label\":\"DNA repair protein RAD51 homolog 3\",\"id\":\"O43502\"},{\"label\":\"DNA repair protein RAD51 homolog 4\",\"id\":\"O75771\"},{\"label\":\"DNA repair protein XRCC2\",\"id\":\"O43543\"},{\"label\":\"DNA repair protein XRCC3\",\"id\":\"O43542\"},{\"label\":\"DNA replication ATP-dependent helicase/nuclease DNA2\",\"id\":\"P51530\"},{\"label\":\"DNA topoisomerase 3-alpha\",\"id\":\"Q13472\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Exonuclease 1\",\"id\":\"Q9UQ84\"},{\"label\":\"Fanconi anemia group J protein\",\"id\":\"Q9BX63\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"Partner and localizer of BRCA2\",\"id\":\"Q86YC2\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"RAD51-associated protein 1\",\"id\":\"Q96B01\"},{\"label\":\"RecQ-like DNA helicase BLM\",\"id\":\"P54132\"},{\"label\":\"RecQ-mediated genome instability protein 1\",\"id\":\"Q9H9A7\"},{\"label\":\"RecQ-mediated genome instability protein 2\",\"id\":\"Q96E14\"},{\"label\":\"Replication factor C subunit 1\",\"id\":\"P35251\"},{\"label\":\"Replication factor C subunit 2\",\"id\":\"P35250\"},{\"label\":\"Replication factor C subunit 3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O15315\",\"O43502\",\"O43542\",\"O43543\",\"O60934\",\"O75771\",\"P0CG47\",\"P0CG48\",\"P12004\",\"P15927\",\"P27694\",\"P28340\",\"P35244\",\"P35249\",\"P35250\",\"P35251\",\"P38398\",\"P40937\",\"P40938\",\"P49005\",\"P49959\",\"P51530\",\"P51587\",\"P54132\",\"P56282\",\"P60896\",\"P62979\",\"P62987\",\"Q06609\",\"Q07864\",\"Q13315\",\"Q13472\",\"Q14191\",\"Q15054\",\"Q86YC2\",\"Q92878\",\"Q92993\",\"Q96B01\",\"Q96E14\",\"Q99708\",\"Q99728\",\"Q9BX63\",\"Q9H9A7\",\"Q9HCU8\",\"Q9NR33\",\"Q9NRF9\",\"Q9UBT6\",\"Q9UQ84\",\"Q9Y253\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1\",\"id\":\"Q9NQ66\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2\",\"id\":\"Q00722\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3\",\"id\":\"Q01970\"},{\"label\":\"Free fatty acid receptor 1\",\"id\":\"O14842\"},{\"label\":\"Guanine nucleotide-binding protein G(q) subunit alpha\",\"id\":\"P50148\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-11\",\"id\":\"P29992\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-14\",\"id\":\"O95837\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-15\",\"id\":\"P30679\"}]", "uniprot_id": "[\"O14842\",\"O95837\",\"P29992\",\"P30679\",\"P50148\",\"Q00722\",\"Q01970\",\"Q9NQ66\"]", "gene_symbol": "[\"FFAR1\",\"GA11\",\"GAQ\",\"GNA11\",\"GNA14\",\"GNA15\",\"GNA16\",\"GNAQ\",\"GPR40\",\"KIAA0581\",\"PLCB1\",\"PLCB2\",\"PLCB3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-35 Signalling", "protein_name": "[{\"label\":\"Calnexin\",\"id\":\"P27824\"},{\"label\":\"Interleukin-12 receptor subunit beta-2\",\"id\":\"Q99665\"},{\"label\":\"Interleukin-12 subunit alpha\",\"id\":\"P29459\"},{\"label\":\"Interleukin-27 receptor subunit alpha\",\"id\":\"Q6UWB1\"},{\"label\":\"Interleukin-27 subunit beta\",\"id\":\"Q14213\"},{\"label\":\"Interleukin-6 receptor subunit beta\",\"id\":\"P40189\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 4\",\"id\":\"Q14765\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"}]", "uniprot_id": "[\"O60674\",\"P23458\",\"P27824\",\"P29459\",\"P29597\",\"P40189\",\"P40763\",\"P42224\",\"Q14213\",\"Q14765\",\"Q6UWB1\",\"Q99665\"]", "gene_symbol": "[\"APRF\",\"CANX\",\"CRL1\",\"EBI3\",\"IL12A\",\"IL12RB2\",\"IL27B\",\"IL27RA\",\"IL6ST\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"JAK2\",\"NKSF1\",\"STAT1\",\"STAT3\",\"STAT4\",\"TCCR\",\"TYK2\",\"WSX1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nef and signal transduction", "protein_name": "[{\"label\":\"Dedicator of cytokinesis protein 2\",\"id\":\"Q92608\"},{\"label\":\"Engulfment and cell motility protein 1\",\"id\":\"Q92556\"},{\"label\":\"Protein Nef\",\"id\":\"P04601\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase HCK\",\"id\":\"P08631\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"}]", "uniprot_id": "[\"P04601\",\"P06239\",\"P06241\",\"P08631\",\"P63000\",\"Q13177\",\"Q92556\",\"Q92608\"]", "gene_symbol": "[\"DOCK2\",\"ELMO1\",\"FYN\",\"HCK\",\"KIAA0209\",\"KIAA0281\",\"LCK\",\"PAK2\",\"RAC1\",\"TC25\",\"nef\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ABO blood group biosynthesis", "protein_name": "[{\"label\":\"Galactoside alpha-(1,2)-fucosyltransferase 1\",\"id\":\"P19526\"},{\"label\":\"Galactoside alpha-(1,2)-fucosyltransferase 2\",\"id\":\"Q10981\"},{\"label\":\"Histo-blood group ABO system transferase\",\"id\":\"P16442\"}]", "uniprot_id": "[\"P16442\",\"P19526\",\"Q10981\"]", "gene_symbol": "[\"ABO\",\"FUT1\",\"FUT2\",\"H\",\"HSC\",\"SEC2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-27 signaling", "protein_name": "[{\"label\":\"Calnexin\",\"id\":\"P27824\"},{\"label\":\"Cytokine receptor-like factor 1\",\"id\":\"O75462\"},{\"label\":\"Interleukin-27 receptor subunit alpha\",\"id\":\"Q6UWB1\"},{\"label\":\"Interleukin-27 subunit alpha\",\"id\":\"Q8NEV9\"},{\"label\":\"Interleukin-27 subunit beta\",\"id\":\"Q14213\"},{\"label\":\"Interleukin-6 receptor subunit beta\",\"id\":\"P40189\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"}]", "uniprot_id": "[\"O60674\",\"O75462\",\"P23458\",\"P27824\",\"P29597\",\"P40189\",\"P40763\",\"P42224\",\"Q14213\",\"Q6UWB1\",\"Q8NEV9\"]", "gene_symbol": "[\"APRF\",\"CANX\",\"CRL1\",\"CRLF1\",\"EBI3\",\"IL27\",\"IL27A\",\"IL27B\",\"IL27RA\",\"IL30\",\"IL6ST\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"JAK2\",\"STAT1\",\"STAT3\",\"TCCR\",\"TYK2\",\"WSX1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "protein_name": "[{\"label\":\"Aggrecan core protein\",\"id\":\"P16112\"},{\"label\":\"Beta-1,4-galactosyltransferase 1\",\"id\":\"P15291\"},{\"label\":\"Fibromodulin\",\"id\":\"Q06828\"},{\"label\":\"Keratocan\",\"id\":\"O60938\"},{\"label\":\"Lumican\",\"id\":\"P51884\"},{\"label\":\"Mimecan\",\"id\":\"P20774\"},{\"label\":\"Osteomodulin\",\"id\":\"Q99983\"},{\"label\":\"Prolargin\",\"id\":\"P51888\"}]", "uniprot_id": "[\"O60938\",\"P15291\",\"P16112\",\"P20774\",\"P51884\",\"P51888\",\"Q06828\",\"Q99983\"]", "gene_symbol": "[\"ACAN\",\"AGC1\",\"B4GALT1\",\"CSPG1\",\"FM\",\"FMOD\",\"GGTB2\",\"KERA\",\"LDC\",\"LUM\",\"MSK16\",\"OGN\",\"OIF\",\"OMD\",\"PRELP\",\"SLRR2A\",\"SLRR2B\",\"SLRR2C\",\"SLRR2D\",\"SLRR2E\",\"SLRR3A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of PUMA and translocation to mitochondria", "protein_name": "[{\"label\":\"Apoptosis-stimulating of p53 protein 1\",\"id\":\"Q96KQ4\"},{\"label\":\"Apoptosis-stimulating of p53 protein 2\",\"id\":\"Q13625\"},{\"label\":\"Bcl-2-binding component 3, isoforms 1/2\",\"id\":\"Q9BXH1\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Tumor protein 63\",\"id\":\"Q9H3D4\"},{\"label\":\"Tumor protein p73\",\"id\":\"O15350\"}]", "uniprot_id": "[\"O15350\",\"P04637\",\"Q01094\",\"Q13625\",\"Q14186\",\"Q14188\",\"Q96KQ4\",\"Q9BXH1\",\"Q9H3D4\"]", "gene_symbol": "[\"ASPP1\",\"ASPP2\",\"BBC3\",\"BBP\",\"DP1\",\"DP2\",\"E2F1\",\"KET\",\"KIAA0771\",\"P53\",\"P63\",\"P73\",\"P73H\",\"P73L\",\"PPP1R13B\",\"PUMA\",\"RBBP3\",\"TFDP1\",\"TFDP2\",\"TP53\",\"TP53BP2\",\"TP63\",\"TP73\",\"TP73L\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nuclear Pore Complex (NPC) Disassembly", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"G2/mitotic-specific cyclin-B2\",\"id\":\"O95067\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Serine/threonine-protein kinase Nek6\",\"id\":\"Q9HC98\"},{\"label\":\"Serine/threonine-protein kinase Nek7\",\"id\":\"Q8TDX7\"},{\"label\":\"Serine/threonine-protein kinase Nek9\",\"id\":\"Q8TD19\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": "[\"A8CG34\",\"O15504\",\"O75694\",\"O95067\",\"P06493\",\"P12270\",\"P14635\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P55735\",\"P57740\",\"P78406\",\"Q12769\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8N1F7\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TD19\",\"Q8TDX7\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q96HA1\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9HC98\",\"Q9NRG9\",\"Q9UKX7\"]", "gene_symbol": 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R\",\"id\":\"Q13352\"},{\"label\":\"Centromere protein S\",\"id\":\"Q8N2Z9\"},{\"label\":\"Centromere protein T\",\"id\":\"Q96BT3\"},{\"label\":\"Centromere protein U\",\"id\":\"Q71F23\"},{\"label\":\"Centromere-associated protein E\",\"id\":\"Q02224\"},{\"label\":\"Centromere/kinetochore protein zw10 homolog\",\"id\":\"O43264\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 1\",\"id\":\"O14576\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 2\",\"id\":\"O43237\"},{\"label\":\"Cytoskeleton-associated protein 5\",\"id\":\"Q14008\"},{\"label\":\"DNA excision repair protein ERCC-6-like\",\"id\":\"Q2NKX8\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, 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1\",\"id\":\"P50748\"},{\"label\":\"Kinetochore-associated protein DSN1 homolog\",\"id\":\"Q9H410\"},{\"label\":\"Kinetochore-associated protein NSL1 homolog\",\"id\":\"Q96IY1\"},{\"label\":\"Microtubule-associated protein RP/EB family member 1\",\"id\":\"Q15691\"},{\"label\":\"Mitotic checkpoint protein BUB3\",\"id\":\"O43684\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta\",\"id\":\"O60566\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1\",\"id\":\"O43683\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD1\",\"id\":\"Q9Y6D9\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2A\",\"id\":\"Q13257\"},{\"label\":\"Nuclear distribution protein nudE homolog 1\",\"id\":\"Q9NXR1\"},{\"label\":\"Nuclear distribution protein nudE-like 1\",\"id\":\"Q9GZM8\"},{\"label\":\"Nuclear migration protein nudC\",\"id\":\"Q9Y266\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore 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subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-gamma catalytic subunit\",\"id\":\"P36873\"},{\"label\":\"Shugoshin 1\",\"id\":\"Q5FBB7\"},{\"label\":\"Shugoshin 2\",\"id\":\"Q562F6\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Spindle and kinetochore-associated protein 2\",\"id\":\"Q8WVK7\"},{\"label\":\"ZW10 interactor\",\"id\":\"O95229\"}]", "uniprot_id": 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"gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "M-decay: degradation of maternal mRNAs by maternally stored factors", "protein_name": "[{\"label\":\"182 kDa tankyrase-1-binding protein\",\"id\":\"Q9C0C2\"},{\"label\":\"CCR4-NOT transcription complex subunit 10\",\"id\":\"Q9H9A5\"},{\"label\":\"CCR4-NOT transcription complex subunit 11\",\"id\":\"Q9UKZ1\"},{\"label\":\"CCR4-NOT transcription complex subunit 1\",\"id\":\"A5YKK6\"},{\"label\":\"CCR4-NOT transcription complex subunit 2\",\"id\":\"Q9NZN8\"},{\"label\":\"CCR4-NOT transcription complex subunit 3\",\"id\":\"O75175\"},{\"label\":\"CCR4-NOT transcription complex subunit 4\",\"id\":\"O95628\"},{\"label\":\"CCR4-NOT transcription complex subunit 6-like\",\"id\":\"Q96LI5\"},{\"label\":\"CCR4-NOT transcription complex subunit 6\",\"id\":\"Q9ULM6\"},{\"label\":\"CCR4-NOT transcription complex subunit 7\",\"id\":\"Q9UIV1\"},{\"label\":\"CCR4-NOT transcription complex subunit 8\",\"id\":\"Q9UFF9\"},{\"label\":\"CCR4-NOT transcription complex subunit 9\",\"id\":\"Q92600\"},{\"label\":\"Embryonic polyadenylate-binding protein 2\",\"id\":\"A6NDY0\"},{\"label\":\"Endoribonuclease Dicer\",\"id\":\"Q9UPY3\"},{\"label\":\"Eukaryotic initiation factor 4A-I\",\"id\":\"P60842\"},{\"label\":\"Eukaryotic initiation factor 4A-II\",\"id\":\"Q14240\"},{\"label\":\"Eukaryotic initiation factor 4A-III\",\"id\":\"P38919\"},{\"label\":\"Eukaryotic translation initiation factor 4 gamma 1\",\"id\":\"Q04637\"},{\"label\":\"Eukaryotic translation initiation factor 4B\",\"id\":\"P23588\"},{\"label\":\"Eukaryotic translation initiation factor 4E\",\"id\":\"P06730\"},{\"label\":\"Polyadenylate-binding protein 1\",\"id\":\"P11940\"},{\"label\":\"Polyadenylate-binding protein-interacting protein 1\",\"id\":\"Q9H074\"},{\"label\":\"Protein BTG4\",\"id\":\"Q9NY30\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"mRNA decay activator protein ZFP36L2\",\"id\":\"P47974\"}]", "uniprot_id": "[\"A5YKK6\",\"A6NDY0\",\"O75175\",\"O95628\",\"P06730\",\"P11940\",\"P23588\",\"P38919\",\"P47974\",\"P60842\",\"Q04637\",\"Q14240\",\"Q92600\",\"Q96LI5\",\"Q9C0C2\",\"Q9H074\",\"Q9H9A5\",\"Q9NY30\",\"Q9NZN8\",\"Q9UFF9\",\"Q9UIV1\",\"Q9UKV8\",\"Q9UKZ1\",\"Q9ULM6\",\"Q9UPY3\"]", "gene_symbol": "[\"AGO2\",\"BTG4\",\"C2orf29\",\"CAF1\",\"CALIF\",\"CCR4\",\"CCR4B\",\"CCR4a\",\"CDC36\",\"CDC39\",\"CNOT1\",\"CNOT10\",\"CNOT11\",\"CNOT2\",\"CNOT3\",\"CNOT4\",\"CNOT6\",\"CNOT6L\",\"CNOT7\",\"CNOT8\",\"CNOT9\",\"DDX2A\",\"DDX2B\",\"DDX48\",\"DICER\",\"DICER1\",\"EIF2C2\",\"EIF4A\",\"EIF4A1\",\"EIF4A2\",\"EIF4A3\",\"EIF4B\",\"EIF4E\",\"EIF4EL1\",\"EIF4F\",\"EIF4G\",\"EIF4G1\",\"EIF4GI\",\"EPABP2\",\"ERF2\",\"HERNA\",\"KIAA0111\",\"KIAA0691\",\"KIAA0928\",\"KIAA1007\",\"KIAA1194\",\"KIAA1741\",\"LENG2\",\"NOT1\",\"NOT2\",\"NOT3\",\"NOT4\",\"PAB1\",\"PABP\",\"PABP1\",\"PABPC1\",\"PABPC2\",\"PABPN1L\",\"PABPNL1\",\"PAIP1\",\"PC3B\",\"POP2\",\"RCD1\",\"RNF162C\",\"RQCD1\",\"TAB182\",\"TIS11D\",\"TNKS1BP1\",\"ZFP36L2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RA biosynthesis pathway", "protein_name": "[{\"label\":\"2-aminomuconic semialdehyde dehydrogenase\",\"id\":\"Q9H2A2\"},{\"label\":\"Alcohol dehydrogenase 1A\",\"id\":\"P07327\"},{\"label\":\"Alcohol dehydrogenase 1C\",\"id\":\"P00326\"},{\"label\":\"Aldehyde dehydrogenase 1A1\",\"id\":\"P00352\"},{\"label\":\"Aldo-keto reductase family 1 member C3\",\"id\":\"P42330\"},{\"label\":\"All-trans-retinol dehydrogenase [NAD(+)] ADH4\",\"id\":\"P08319\"},{\"label\":\"Cellular retinoic acid-binding protein 1\",\"id\":\"P29762\"},{\"label\":\"Cytochrome P450 26A1\",\"id\":\"O43174\"},{\"label\":\"Cytochrome P450 26B1\",\"id\":\"Q9NR63\"},{\"label\":\"Cytochrome P450 26C1\",\"id\":\"Q6V0L0\"},{\"label\":\"Dehydrogenase/reductase SDR family member 4\",\"id\":\"Q9BTZ2\"},{\"label\":\"Dehydrogenase/reductase SDR family member 9\",\"id\":\"Q9BPW9\"},{\"label\":\"Epidermal retinol dehydrogenase 2\",\"id\":\"Q8N3Y7\"},{\"label\":\"Retinal dehydrogenase 2\",\"id\":\"O94788\"},{\"label\":\"Retinaldehyde dehydrogenase 3\",\"id\":\"P47895\"},{\"label\":\"Retinol dehydrogenase 10\",\"id\":\"Q8IZV5\"},{\"label\":\"Retinol dehydrogenase 11\",\"id\":\"Q8TC12\"},{\"label\":\"Retinol dehydrogenase 13\",\"id\":\"Q8NBN7\"},{\"label\":\"Retinol dehydrogenase 14\",\"id\":\"Q9HBH5\"},{\"label\":\"Retinol dehydrogenase 16\",\"id\":\"O75452\"},{\"label\":\"Retinol dehydrogenase 5\",\"id\":\"Q92781\"},{\"label\":\"Short-chain dehydrogenase/reductase 3\",\"id\":\"O75911\"}]", "uniprot_id": "[\"O43174\",\"O75452\",\"O75911\",\"O94788\",\"P00326\",\"P00352\",\"P07327\",\"P08319\",\"P29762\",\"P42330\",\"P47895\",\"Q6V0L0\",\"Q8IZV5\",\"Q8N3Y7\",\"Q8NBN7\",\"Q8TC12\",\"Q92781\",\"Q9BPW9\",\"Q9BTZ2\",\"Q9H2A2\",\"Q9HBH5\",\"Q9NR63\"]", "gene_symbol": 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"[\"COMT\",\"COMT2\",\"LRTOMT\",\"MAOA\",\"TOMT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IRS-mediated signalling", "protein_name": "[{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"}]", "uniprot_id": "[\"O00459\",\"P27986\",\"P35568\",\"P42336\",\"P42338\",\"Q9Y4H2\"]", "gene_symbol": "[\"GRB1\",\"IRS1\",\"IRS2\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3R1\",\"PIK3R2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Beta-catenin phosphorylation cascade", "protein_name": "[{\"label\":\"APC membrane recruitment protein 1\",\"id\":\"Q5JTC6\"},{\"label\":\"Adenomatous polyposis coli protein\",\"id\":\"P25054\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Casein kinase I isoform alpha\",\"id\":\"P48729\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"GSK-3-binding protein FRAT2\",\"id\":\"O75474\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Proto-oncogene FRAT1\",\"id\":\"Q92837\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma 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"gtc_id": "[\"\"]" }, { "pathway_label": "CD22 mediated BCR regulation", "protein_name": "[{\"label\":\"B-cell antigen receptor complex-associated protein alpha chain\",\"id\":\"P11912\"},{\"label\":\"B-cell antigen receptor complex-associated protein beta chain\",\"id\":\"P40259\"},{\"label\":\"B-cell receptor CD22\",\"id\":\"P20273\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant delta\",\"id\":\"P01880\"},{\"label\":\"Immunoglobulin heavy constant mu\",\"id\":\"P01871\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 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1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 2-8\",\"id\":\"P01709\"},{\"label\":\"Immunoglobulin lambda variable 3-19\",\"id\":\"P01714\"},{\"label\":\"Immunoglobulin lambda variable 3-1\",\"id\":\"P01715\"},{\"label\":\"Immunoglobulin lambda variable 3-21\",\"id\":\"P80748\"},{\"label\":\"Immunoglobulin lambda variable 3-25\",\"id\":\"P01717\"},{\"label\":\"Immunoglobulin lambda variable 3-27\",\"id\":\"P01718\"},{\"label\":\"Immunoglobulin lambda variable 6-57\",\"id\":\"P01721\"},{\"label\":\"Immunoglobulin lambda variable 7-43\",\"id\":\"P04211\"},{\"label\":\"Immunolglobulin kappa light chain variable region L22 (Fragment)\",\"id\":\"A2NXD2\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"},{\"label\":\"UGa8H (Fragment)\",\"id\":\"A2KUC3\"}]", "uniprot_id": "[\"A0A075B6P5\",\"A0A075B6S6\",\"A0A0C4DH25\",\"A0A0C4DH73\",\"A0M8Q6\",\"A2KUC3\",\"A2NJV5\",\"A2NXD2\",\"P01593\",\"P01594\",\"P01597\",\"P01599\",\"P01601\",\"P01602\",\"P01611\",\"P01614\",\"P01615\",\"P01619\",\"P01624\",\"P01699\",\"P01700\",\"P01701\",\"P01703\",\"P01704\",\"P01705\",\"P01706\",\"P01709\",\"P01714\",\"P01715\",\"P01717\",\"P01718\",\"P01721\",\"P01742\",\"P01743\",\"P01762\",\"P01763\",\"P01764\",\"P01766\",\"P01767\",\"P01768\",\"P01772\",\"P01780\",\"P01782\",\"P01814\",\"P01817\",\"P01824\",\"P01825\",\"P01834\",\"P01871\",\"P01880\",\"P04211\",\"P04430\",\"P04432\",\"P04433\",\"P06310\",\"P06312\",\"P06315\",\"P06331\",\"P07948\",\"P0CF74\",\"P0CG04\",\"P0DOY2\",\"P0DOY3\",\"P11912\",\"P20273\",\"P23083\",\"P29350\",\"P40259\",\"P80748\",\"Q6PIL0\"]", "gene_symbol": 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mitochondrial:A6NK58\"}]", "uniprot_id": "[\"A6NK58\",\"O14561\",\"O43766\",\"P10109\",\"P10515\",\"P11182\",\"P23434\",\"P36957\",\"Q9UMS0\",\"Q9Y234\"]", "gene_symbol": "[\"ADX\",\"BCATE2\",\"BCKDHE2\",\"DBT\",\"DLAT\",\"DLST\",\"DLTA\",\"DLTS\",\"FDX1\",\"GCSH\",\"HIRIP5\",\"LAS\",\"LIAS\",\"LIPT1\",\"LIPT2\",\"NDUFAB1\",\"NFU1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Keratan sulfate degradation", "protein_name": "[{\"label\":\"Aggrecan core protein\",\"id\":\"P16112\"},{\"label\":\"Beta-galactosidase-1-like protein 2\",\"id\":\"Q8IW92\"},{\"label\":\"Beta-galactosidase-1-like protein 3\",\"id\":\"Q8NCI6\"},{\"label\":\"Beta-galactosidase-1-like protein\",\"id\":\"Q6UWU2\"},{\"label\":\"Beta-galactosidase\",\"id\":\"P16278\"},{\"label\":\"Beta-hexosaminidase subunit alpha\",\"id\":\"P06865\"},{\"label\":\"Beta-hexosaminidase subunit beta\",\"id\":\"P07686\"},{\"label\":\"Fibromodulin\",\"id\":\"Q06828\"},{\"label\":\"Keratocan\",\"id\":\"O60938\"},{\"label\":\"Lumican\",\"id\":\"P51884\"},{\"label\":\"Mimecan\",\"id\":\"P20774\"},{\"label\":\"N-acetylglucosamine-6-sulfatase\",\"id\":\"P15586\"},{\"label\":\"Osteomodulin\",\"id\":\"Q99983\"},{\"label\":\"Prolargin\",\"id\":\"P51888\"}]", "uniprot_id": "[\"O60938\",\"P06865\",\"P07686\",\"P15586\",\"P16112\",\"P16278\",\"P20774\",\"P51884\",\"P51888\",\"Q06828\",\"Q6UWU2\",\"Q8IW92\",\"Q8NCI6\",\"Q99983\"]", "gene_symbol": "[\"ACAN\",\"AGC1\",\"CSPG1\",\"ELNR1\",\"FM\",\"FMOD\",\"GLB1\",\"GLB1L\",\"GLB1L2\",\"GLB1L3\",\"GNS\",\"HEXA\",\"HEXB\",\"KERA\",\"LDC\",\"LUM\",\"MSK16\",\"OGN\",\"OIF\",\"OMD\",\"PRELP\",\"SLRR2A\",\"SLRR2B\",\"SLRR2C\",\"SLRR2D\",\"SLRR2E\",\"SLRR3A\"]", "gtc_id": "[\"G09546QO\",\"G20239CJ\",\"G27025MB\",\"G50451AA\",\"G80016QC\",\"G82768YB\",\"G85384LV\"]" }, { "pathway_label": "Leukotriene receptors", "protein_name": 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acetylcholine receptor subunit alpha-9\",\"id\":\"Q9UGM1\"},{\"label\":\"Small conductance calcium-activated potassium channel protein 2\",\"id\":\"Q9H2S1\"}]", "uniprot_id": "[\"Q12791\",\"Q16558\",\"Q9GZZ6\",\"Q9H2S1\",\"Q9UGM1\"]", "gene_symbol": "[\"CHRNA10\",\"CHRNA9\",\"KCNMA\",\"KCNMA1\",\"KCNMB1\",\"KCNN2\",\"NACHRA10\",\"NACHRA9\",\"SLO\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA", "protein_name": "[{\"label\":\"Enoyl-CoA hydratase, mitochondrial\",\"id\":\"P30084\"},{\"label\":\"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial\",\"id\":\"Q16836\"},{\"label\":\"Long-chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P28330\"},{\"label\":\"Trifunctional enzyme subunit alpha, mitochondrial\",\"id\":\"P40939\"},{\"label\":\"Trifunctional enzyme subunit beta, mitochondrial\",\"id\":\"P55084\"}]", "uniprot_id": "[\"P28330\",\"P30084\",\"P40939\",\"P55084\",\"Q16836\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "COPI-independent Golgi-to-ER retrograde traffic", "protein_name": "[{\"label\":\"1-acyl-sn-glycerol-3-phosphate acyltransferase gamma\",\"id\":\"Q9NRZ7\"},{\"label\":\"85/88 kDa calcium-independent phospholipase A2\",\"id\":\"O60733\"},{\"label\":\"Actin-related protein 10\",\"id\":\"Q9NZ32\"},{\"label\":\"Alpha-centractin\",\"id\":\"P61163\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 1\",\"id\":\"O14576\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 2\",\"id\":\"O43237\"},{\"label\":\"Cytosolic phospholipase A2\",\"id\":\"P47712\"},{\"label\":\"Dynactin subunit 1\",\"id\":\"Q14203\"},{\"label\":\"Dynactin subunit 2\",\"id\":\"Q13561\"},{\"label\":\"Dynactin subunit 3\",\"id\":\"O75935\"},{\"label\":\"Dynactin subunit 4\",\"id\":\"Q9UJW0\"},{\"label\":\"Dynactin subunit 5\",\"id\":\"Q9BTE1\"},{\"label\":\"Dynactin subunit 6\",\"id\":\"O00399\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"F-actin-capping protein subunit alpha-1\",\"id\":\"P52907\"},{\"label\":\"F-actin-capping protein subunit alpha-2\",\"id\":\"P47755\"},{\"label\":\"F-actin-capping protein subunit alpha-3\",\"id\":\"Q96KX2\"},{\"label\":\"F-actin-capping protein subunit beta\",\"id\":\"P47756\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit alpha1\",\"id\":\"Q15102\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit alpha2\",\"id\":\"P68402\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit beta\",\"id\":\"P43034\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 1\",\"id\":\"Q10472\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 2\",\"id\":\"Q10471\"},{\"label\":\"Protein bicaudal D homolog 1\",\"id\":\"Q96G01\"},{\"label\":\"Protein bicaudal D homolog 2\",\"id\":\"Q8TD16\"},{\"label\":\"Rab3 GTPase-activating protein catalytic subunit\",\"id\":\"Q15042\"},{\"label\":\"Rab3 GTPase-activating protein non-catalytic subunit\",\"id\":\"Q9H2M9\"},{\"label\":\"Ras-related protein Rab-18\",\"id\":\"Q9NP72\"},{\"label\":\"Ras-related protein Rab-6A\",\"id\":\"P20340\"},{\"label\":\"Ras-related protein Rab-6B\",\"id\":\"Q9NRW1\"}]", "uniprot_id": "[\"O00399\",\"O14576\",\"O43237\",\"O60733\",\"O75935\",\"P20340\",\"P43034\",\"P47712\",\"P47755\",\"P47756\",\"P52907\",\"P61163\",\"P63167\",\"P68402\",\"Q10471\",\"Q10472\",\"Q13409\",\"Q13561\",\"Q14203\",\"Q14204\",\"Q15042\",\"Q15102\",\"Q8TD16\",\"Q96FJ2\",\"Q96G01\",\"Q96KX2\",\"Q9BTE1\",\"Q9H2M9\",\"Q9NP72\",\"Q9NRW1\",\"Q9NRZ7\",\"Q9NZ32\",\"Q9UJW0\",\"Q9Y6G9\"]", "gene_symbol": 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2\",\"id\":\"O76082\"},{\"label\":\"Regulatory solute carrier protein family 1 member 1\",\"id\":\"Q92681\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"},{\"label\":\"Solute carrier family 22 member 15\",\"id\":\"Q8IZD6\"},{\"label\":\"Solute carrier family 22 member 16\",\"id\":\"Q86VW1\"},{\"label\":\"Solute carrier family 22 member 18\",\"id\":\"Q96BI1\"},{\"label\":\"Solute carrier family 22 member 1\",\"id\":\"O15245\"},{\"label\":\"Solute carrier family 22 member 2\",\"id\":\"O15244\"},{\"label\":\"Solute carrier family 22 member 3\",\"id\":\"O75751\"},{\"label\":\"Solute carrier family 22 member 4\",\"id\":\"Q9H015\"}]", "uniprot_id": "[\"O15244\",\"O15245\",\"O75751\",\"O76082\",\"Q01196\",\"Q86VW1\",\"Q8IZD6\",\"Q92681\",\"Q96BI1\",\"Q9H015\"]", "gene_symbol": "[\"AML1\",\"BWR1A\",\"BWSCR1A\",\"CBFA2\",\"EMTH\",\"ETT\",\"FLIPT1\",\"HET\",\"IMPT1\",\"ITM\",\"OCT1\",\"OCT2\",\"OCT3\",\"OCT6\",\"OCTN1\",\"OCTN2\",\"ORCTL2\",\"RSC1A1\",\"RUNX1\",\"SLC22A1\",\"SLC22A15\",\"SLC22A16\",\"SLC22A18\",\"SLC22A1L\",\"SLC22A2\",\"SLC22A3\",\"SLC22A4\",\"SLC22A5\",\"TSSC5\",\"UT2H\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Attenuation phase", "protein_name": "[{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"DnaJ homolog subfamily B member 1\",\"id\":\"P25685\"},{\"label\":\"Heat shock 70 kDa protein 1-like\",\"id\":\"P34931\"},{\"label\":\"Heat shock 70 kDa protein 1A\",\"id\":\"P0DMV8\"},{\"label\":\"Heat shock 70 kDa protein 1B\",\"id\":\"P0DMV9\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Heat shock factor protein 1\",\"id\":\"Q00613\"},{\"label\":\"Heat shock factor-binding protein 1\",\"id\":\"O75506\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Heat shock-related 70 kDa protein 2\",\"id\":\"P54652\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase FKBP4\",\"id\":\"Q02790\"},{\"label\":\"Prostaglandin E synthase 3\",\"id\":\"Q15185\"}]", "uniprot_id": "[\"O75506\",\"P07900\",\"P08238\",\"P0DMV8\",\"P0DMV9\",\"P11142\",\"P25685\",\"P34931\",\"P54652\",\"Q00613\",\"Q02790\",\"Q09472\",\"Q15185\",\"Q92793\"]", "gene_symbol": "[\"CBP\",\"CREBBP\",\"DNAJ1\",\"DNAJB1\",\"EP300\",\"FKBP4\",\"FKBP52\",\"HDJ1\",\"HSBP1\",\"HSC70\",\"HSF1\",\"HSF1BP\",\"HSP72\",\"HSP73\",\"HSP90A\",\"HSP90AA1\",\"HSP90AB1\",\"HSP90B\",\"HSPA1\",\"HSPA10\",\"HSPA1A\",\"HSPA1B\",\"HSPA1L\",\"HSPA2\",\"HSPA8\",\"HSPC1\",\"HSPC2\",\"HSPC3\",\"HSPCA\",\"HSPCB\",\"HSPF1\",\"HSTF1\",\"HSX70\",\"P23\",\"P300\",\"PTGES3\",\"TEBP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Tat-mediated elongation of the HIV-1 transcript", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Elongin-A2\",\"id\":\"Q8IYF1\"},{\"label\":\"Elongin-A\",\"id\":\"Q14241\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"FACT complex subunit SPT16\",\"id\":\"Q9Y5B9\"},{\"label\":\"FACT complex subunit SSRP1\",\"id\":\"Q08945\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Negative elongation factor A\",\"id\":\"Q9H3P2\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"},{\"label\":\"Negative elongation factor C/D\",\"id\":\"Q8IXH7\"},{\"label\":\"Negative elongation factor E\",\"id\":\"P18615\"},{\"label\":\"Protein Tat\",\"id\":\"P04608\"},{\"label\":\"RNA polymerase II elongation factor ELL\",\"id\":\"P55199\"},{\"label\":\"RNA polymerase II subunit A C-terminal domain phosphatase\",\"id\":\"Q9Y5B0\"},{\"label\":\"Transcription elongation factor A protein 1\",\"id\":\"P23193\"},{\"label\":\"Transcription elongation factor SPT4\",\"id\":\"P63272\"},{\"label\":\"Transcription elongation factor SPT5\",\"id\":\"O00267\"}]", "uniprot_id": "[\"O00267\",\"O15514\",\"O60563\",\"P04608\",\"P13984\",\"P18074\",\"P18615\",\"P19387\",\"P19388\",\"P19447\",\"P23193\",\"P24928\",\"P30876\",\"P32780\",\"P35269\",\"P36954\",\"P50613\",\"P50750\",\"P51946\",\"P51948\",\"P52434\",\"P52435\",\"P53803\",\"P55199\",\"P61218\",\"P62487\",\"P62875\",\"P63272\",\"Q08945\",\"Q13888\",\"Q13889\",\"Q14241\",\"Q15369\",\"Q15370\",\"Q6ZYL4\",\"Q8IXH7\",\"Q8IYF1\",\"Q8WX92\",\"Q92759\",\"Q9H3P2\",\"Q9Y5B0\",\"Q9Y5B9\"]", "gene_symbol": 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Initiation From Type 2 Promoter", "protein_name": "[{\"label\":\"DNA-directed RNA polymerase III subunit RPC10\",\"id\":\"Q9Y2Y1\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC1\",\"id\":\"O14802\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC2\",\"id\":\"Q9NW08\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC3\",\"id\":\"Q9BUI4\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC4\",\"id\":\"P05423\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC5\",\"id\":\"Q9NVU0\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC6\",\"id\":\"Q9H1D9\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7-like\",\"id\":\"Q9BT43\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7\",\"id\":\"O15318\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC8\",\"id\":\"Q9Y535\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC9\",\"id\":\"O75575\"},{\"label\":\"DNA-directed RNA polymerases I and III subunit RPAC1\",\"id\":\"O15160\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription factor 3C polypeptide 1\",\"id\":\"Q12789\"},{\"label\":\"General transcription factor 3C polypeptide 2\",\"id\":\"Q8WUA4\"},{\"label\":\"General transcription factor 3C polypeptide 3\",\"id\":\"Q9Y5Q9\"},{\"label\":\"General transcription factor 3C polypeptide 4\",\"id\":\"Q9UKN8\"},{\"label\":\"General transcription factor 3C polypeptide 5\",\"id\":\"Q9Y5Q8\"},{\"label\":\"General transcription factor 3C polypeptide 6\",\"id\":\"Q969F1\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription factor IIIB 90 kDa subunit\",\"id\":\"Q92994\"},{\"label\":\"Transcription factor TFIIIB component B'' homolog\",\"id\":\"A6H8Y1\"}]", "uniprot_id": "[\"A6H8Y1\",\"O14802\",\"O15160\",\"O15318\",\"O75575\",\"P05423\",\"P0DPB5\",\"P19388\",\"P20226\",\"P52434\",\"P53803\",\"P61218\",\"P62875\",\"Q12789\",\"Q8WUA4\",\"Q92994\",\"Q969F1\",\"Q9BT43\",\"Q9BUI4\",\"Q9H1D9\",\"Q9NVU0\",\"Q9NW08\",\"Q9UKN8\",\"Q9Y2Y1\",\"Q9Y535\",\"Q9Y5Q8\",\"Q9Y5Q9\"]", "gene_symbol": "[\"BDP1\",\"BN51\",\"BN51T\",\"BRF\",\"BRF1\",\"C6orf51\",\"CRCP\",\"GTF2D1\",\"GTF3B\",\"GTF3C1\",\"GTF3C2\",\"GTF3C3\",\"GTF3C4\",\"GTF3C5\",\"GTF3C6\",\"KIAA0011\",\"KIAA1241\",\"KIAA1452\",\"KIAA1665\",\"KIAA1689\",\"POLR1C\",\"POLR1D\",\"POLR1E\",\"POLR2E\",\"POLR2F\",\"POLR2H\",\"POLR2K\",\"POLR2L\",\"POLR3A\",\"POLR3B\",\"POLR3C\",\"POLR3D\",\"POLR3E\",\"POLR3F\",\"POLR3G\",\"POLR3GL\",\"POLR3H\",\"POLR3K\",\"POLRF\",\"RPC11\",\"RPC8\",\"TAF3B2\",\"TAF3C\",\"TBP\",\"TF2D\",\"TFIID\",\"TFNR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Sema3A PAK dependent Axon repulsion", "protein_name": "[{\"label\":\"Cofilin-1\",\"id\":\"P23528\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"LIM domain kinase 1\",\"id\":\"P53667\"},{\"label\":\"Neuropilin-1\",\"id\":\"O14786\"},{\"label\":\"Plexin-A1\",\"id\":\"Q9UIW2\"},{\"label\":\"Plexin-A2\",\"id\":\"O75051\"},{\"label\":\"Plexin-A3\",\"id\":\"P51805\"},{\"label\":\"Plexin-A4\",\"id\":\"Q9HCM2\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Semaphorin-3A\",\"id\":\"Q14563\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"Tyrosine-protein kinase Fes/Fps\",\"id\":\"P07332\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"}]", "uniprot_id": "[\"O14786\",\"O75051\",\"O75914\",\"P06241\",\"P07332\",\"P07900\",\"P08238\",\"P23528\",\"P51805\",\"P53667\",\"P63000\",\"Q13153\",\"Q13177\",\"Q14563\",\"Q9HCM2\",\"Q9UIW2\"]", "gene_symbol": "[\"CFL\",\"CFL1\",\"FES\",\"FPS\",\"FYN\",\"HSP90A\",\"HSP90AA1\",\"HSP90AB1\",\"HSP90B\",\"HSPC1\",\"HSPC2\",\"HSPC3\",\"HSPCA\",\"HSPCB\",\"KIAA0463\",\"KIAA1550\",\"LIMK\",\"LIMK1\",\"NOV\",\"NRP\",\"NRP1\",\"OCT\",\"OPHN3\",\"PAK1\",\"PAK2\",\"PAK3\",\"PLXN1\",\"PLXN2\",\"PLXN4\",\"PLXNA1\",\"PLXNA2\",\"PLXNA3\",\"PLXNA4\",\"PLXNA4A\",\"PLXNA4B\",\"RAC1\",\"SEMA3A\",\"SEMAD\",\"SEX\",\"TC25\",\"VEGF165R\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "O-linked glycosylation of mucins", "protein_name": "[{\"label\":\"Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\",\"id\":\"Q6ZMB0\"},{\"label\":\"Alpha-1,4-N-acetylglucosaminyltransferase\",\"id\":\"Q9UNA3\"},{\"label\":\"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3\",\"id\":\"O95395\"},{\"label\":\"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4\",\"id\":\"Q9P109\"},{\"label\":\"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7\",\"id\":\"Q6ZNI0\"},{\"label\":\"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\",\"id\":\"Q02742\"},{\"label\":\"Beta-1,4-galactosyltransferase 5\",\"id\":\"O43286\"},{\"label\":\"Beta-1,4-galactosyltransferase 6\",\"id\":\"Q9UBX8\"},{\"label\":\"C1GALT1-specific chaperone 1\",\"id\":\"Q96EU7\"},{\"label\":\"Carbohydrate sulfotransferase 4\",\"id\":\"Q8NCG5\"},{\"label\":\"Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1\",\"id\":\"Q9NS00\"},{\"label\":\"Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5\",\"id\":\"Q7Z4T8\"},{\"label\":\"Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase\",\"id\":\"Q9BYG0\"},{\"label\":\"Mucin-12\",\"id\":\"Q9UKN1\"},{\"label\":\"Mucin-13\",\"id\":\"Q9H3R2\"},{\"label\":\"Mucin-15\",\"id\":\"Q8N387\"},{\"label\":\"Mucin-16\",\"id\":\"Q8WXI7\"},{\"label\":\"Mucin-17\",\"id\":\"Q685J3\"},{\"label\":\"Mucin-19\",\"id\":\"Q7Z5P9\"},{\"label\":\"Mucin-1\",\"id\":\"P15941\"},{\"label\":\"Mucin-20\",\"id\":\"Q8N307\"},{\"label\":\"Mucin-21\",\"id\":\"Q5SSG8\"},{\"label\":\"Mucin-2\",\"id\":\"Q02817\"},{\"label\":\"Mucin-3A\",\"id\":\"Q02505\"},{\"label\":\"Mucin-3B\",\"id\":\"Q9H195\"},{\"label\":\"Mucin-4\",\"id\":\"Q99102\"},{\"label\":\"Mucin-5AC\",\"id\":\"P98088\"},{\"label\":\"Mucin-5B\",\"id\":\"Q9HC84\"},{\"label\":\"Mucin-6\",\"id\":\"Q6W4X9\"},{\"label\":\"Mucin-7\",\"id\":\"Q8TAX7\"},{\"label\":\"Mucin-like protein 1\",\"id\":\"Q96DR8\"},{\"label\":\"N-acetylgalactosaminyltransferase 7\",\"id\":\"Q86SF2\"},{\"label\":\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2\",\"id\":\"Q9NY97\"},{\"label\":\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3\",\"id\":\"Q9Y2A9\"},{\"label\":\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4\",\"id\":\"Q9C0J1\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 10\",\"id\":\"Q86SR1\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 11\",\"id\":\"Q8NCW6\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 12\",\"id\":\"Q8IXK2\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 13\",\"id\":\"Q8IUC8\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 14\",\"id\":\"Q96FL9\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 15\",\"id\":\"Q8N3T1\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 16\",\"id\":\"Q8N428\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 17\",\"id\":\"Q6IS24\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 18\",\"id\":\"Q6P9A2\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 1\",\"id\":\"Q10472\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 2\",\"id\":\"Q10471\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 3\",\"id\":\"Q14435\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 4\",\"id\":\"Q8N4A0\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 5\",\"id\":\"Q7Z7M9\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 6\",\"id\":\"Q8NCL4\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 9\",\"id\":\"Q9HCQ5\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase-like 6\",\"id\":\"Q49A17\"},{\"label\":\"Probable polypeptide N-acetylgalactosaminyltransferase 8\",\"id\":\"Q9NY28\"},{\"label\":\"Queuosine-tRNA galactosyltransferase\",\"id\":\"Q67FW5\"},{\"label\":\"UDP-GlcNAc\",\"id\":\"betaGal beta-1,3-N-acetylglucosaminyltransferase 7:Q8NFL0\"},{\"label\":\"UDP-GlcNAc\",\"id\":\"betaGal beta-1,3-N-acetylglucosaminyltransferase 8:Q7Z7M8\"},{\"label\":\"UDP-GlcNAc\",\"id\":\"betaGal beta-1,3-N-acetylglucosaminyltransferase 9:Q6UX72\"}]", "uniprot_id": "[\"O43286\",\"O95395\",\"P15941\",\"P98088\",\"Q02505\",\"Q02742\",\"Q02817\",\"Q10471\",\"Q10472\",\"Q14435\",\"Q49A17\",\"Q5SSG8\",\"Q67FW5\",\"Q685J3\",\"Q6IS24\",\"Q6P9A2\",\"Q6UX72\",\"Q6W4X9\",\"Q6ZMB0\",\"Q6ZNI0\",\"Q7Z4T8\",\"Q7Z5P9\",\"Q7Z7M8\",\"Q7Z7M9\",\"Q86SF2\",\"Q86SR1\",\"Q8IUC8\",\"Q8IXK2\",\"Q8N307\",\"Q8N387\",\"Q8N3T1\",\"Q8N428\",\"Q8N4A0\",\"Q8NCG5\",\"Q8NCL4\",\"Q8NCW6\",\"Q8NFL0\",\"Q8TAX7\",\"Q8WXI7\",\"Q96DR8\",\"Q96EU7\",\"Q96FL9\",\"Q99102\",\"Q9BYG0\",\"Q9C0J1\",\"Q9H195\",\"Q9H3R2\",\"Q9HC84\",\"Q9HCQ5\",\"Q9NS00\",\"Q9NY28\",\"Q9NY97\",\"Q9P109\",\"Q9UBX8\",\"Q9UKN1\",\"Q9UNA3\",\"Q9Y2A9\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Glutathione conjugation", "protein_name": "[{\"label\":\"Aldo-keto reductase family 1 member A1\",\"id\":\"P14550\"},{\"label\":\"Glutathione S-transferase 3, mitochondrial\",\"id\":\"O14880\"},{\"label\":\"Glutathione S-transferase A1\",\"id\":\"P08263\"},{\"label\":\"Glutathione S-transferase A2\",\"id\":\"P09210\"},{\"label\":\"Glutathione S-transferase A3\",\"id\":\"Q16772\"},{\"label\":\"Glutathione S-transferase A4\",\"id\":\"O15217\"},{\"label\":\"Glutathione S-transferase A5\",\"id\":\"Q7RTV2\"},{\"label\":\"Glutathione S-transferase Mu 1\",\"id\":\"P09488\"},{\"label\":\"Glutathione S-transferase Mu 2\",\"id\":\"P28161\"},{\"label\":\"Glutathione S-transferase Mu 3\",\"id\":\"P21266\"},{\"label\":\"Glutathione S-transferase Mu 4\",\"id\":\"Q03013\"},{\"label\":\"Glutathione S-transferase Mu 5\",\"id\":\"P46439\"},{\"label\":\"Glutathione S-transferase P\",\"id\":\"P09211\"},{\"label\":\"Glutathione S-transferase kappa 1\",\"id\":\"Q9Y2Q3\"},{\"label\":\"Glutathione S-transferase omega-1\",\"id\":\"P78417\"},{\"label\":\"Glutathione S-transferase omega-2\",\"id\":\"Q9H4Y5\"},{\"label\":\"Glutathione S-transferase theta-1\",\"id\":\"P30711\"},{\"label\":\"Glutathione S-transferase theta-2\",\"id\":\"P0CG29\"},{\"label\":\"Glutathione S-transferase theta-2B\",\"id\":\"P0CG30\"},{\"label\":\"Hematopoietic prostaglandin D synthase\",\"id\":\"O60760\"},{\"label\":\"Maleylacetoacetate isomerase\",\"id\":\"O43708\"},{\"label\":\"Microsomal glutathione S-transferase 1\",\"id\":\"P10620\"},{\"label\":\"Microsomal glutathione S-transferase 2\",\"id\":\"Q99735\"},{\"label\":\"S-formylglutathione hydrolase\",\"id\":\"P10768\"}]", "uniprot_id": "[\"O14880\",\"O15217\",\"O43708\",\"O60760\",\"P08263\",\"P09210\",\"P09211\",\"P09488\",\"P0CG29\",\"P0CG30\",\"P10620\",\"P10768\",\"P14550\",\"P21266\",\"P28161\",\"P30711\",\"P46439\",\"P78417\",\"Q03013\",\"Q16772\",\"Q7RTV2\",\"Q99735\",\"Q9H4Y5\",\"Q9Y2Q3\"]", "gene_symbol": "[\"AKR1A1\",\"ALDR1\",\"ALR\",\"ESD\",\"FAEES3\",\"GST1\",\"GST12\",\"GST2\",\"GST3\",\"GST4\",\"GST5\",\"GSTA1\",\"GSTA2\",\"GSTA3\",\"GSTA4\",\"GSTA5\",\"GSTK1\",\"GSTM1\",\"GSTM2\",\"GSTM3\",\"GSTM4\",\"GSTM5\",\"GSTO1\",\"GSTO2\",\"GSTP1\",\"GSTS\",\"GSTT1\",\"GSTT2\",\"GSTT2B\",\"GSTTLP28\",\"GSTZ1\",\"HPGDS\",\"MAAI\",\"MGST\",\"MGST1\",\"MGST2\",\"MGST3\",\"PGDS\",\"PTGDS2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Pyruvate metabolism", "protein_name": "[{\"label\":\"Alanine aminotransferase 1\",\"id\":\"P24298\"},{\"label\":\"L-lactate dehydrogenase A chain\",\"id\":\"P00338\"},{\"label\":\"L-lactate dehydrogenase A-like 6A\",\"id\":\"Q6ZMR3\"},{\"label\":\"L-lactate dehydrogenase A-like 6B\",\"id\":\"Q9BYZ2\"},{\"label\":\"L-lactate dehydrogenase B chain\",\"id\":\"P07195\"},{\"label\":\"L-lactate dehydrogenase C chain\",\"id\":\"P07864\"},{\"label\":\"Lactoylglutathione lyase\",\"id\":\"Q04760\"},{\"label\":\"Mitochondrial pyruvate carrier 1-like protein\",\"id\":\"P0DKB6\"},{\"label\":\"Mitochondrial pyruvate carrier 1\",\"id\":\"Q9Y5U8\"},{\"label\":\"Mitochondrial pyruvate carrier 2\",\"id\":\"O95563\"},{\"label\":\"NAD-dependent malic enzyme, mitochondrial\",\"id\":\"P23368\"},{\"label\":\"NADP-dependent malic enzyme, mitochondrial\",\"id\":\"Q16798\"},{\"label\":\"NADP-dependent malic enzyme\",\"id\":\"P48163\"},{\"label\":\"Non-selective voltage-gated ion channel VDAC1\",\"id\":\"P21796\"},{\"label\":\"Oxaloacetate tautomerase FAHD1, mitochondrial\",\"id\":\"Q6P587\"},{\"label\":\"Pyruvate carboxylase, mitochondrial\",\"id\":\"P11498\"}]", "uniprot_id": "[\"O95563\",\"P00338\",\"P07195\",\"P07864\",\"P0DKB6\",\"P11498\",\"P21796\",\"P23368\",\"P24298\",\"P48163\",\"Q04760\",\"Q16798\",\"Q6P587\",\"Q6ZMR3\",\"Q9BYZ2\",\"Q9Y5U8\"]", "gene_symbol": 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AP9-7\",\"KRTAP9-8\",\"KRTAP9-9\",\"KRTAP9.1\",\"KRTAP9.2\",\"KRTAP9.3\",\"KRTAP9.4\",\"KRTAP9.5\",\"KRTAP9.6\",\"KRTAP9.7\",\"KRTAP9.8\",\"KRTAP9.9\",\"KRTAP9L1\",\"KRTAP9L2\",\"KRTAP9L3\",\"KRTB\",\"KRTHA1\",\"KRTHA2\",\"KRTHA3A\",\"KRTHA3B\",\"KRTHA4\",\"KRTHA5\",\"KRTHA6\",\"KRTHA7\",\"KRTHA8\",\"KRTHB1\",\"KRTHB2\",\"KRTHB3\",\"KRTHB4\",\"KRTHB5\",\"KRTHB6\",\"KRTL1\",\"MLN137\",\"PKP1\",\"PKP2\",\"PKP3\",\"PKP4\",\"SCL\",\"UHSK1\",\"UHSKB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "AKT phosphorylates targets in the nucleus", "protein_name": "[{\"label\":\"Forkhead box protein O1\",\"id\":\"Q12778\"},{\"label\":\"Forkhead box protein O3\",\"id\":\"O43524\"},{\"label\":\"Forkhead box protein O4\",\"id\":\"P98177\"},{\"label\":\"Forkhead box protein O6\",\"id\":\"A8MYZ6\"},{\"label\":\"Nuclear receptor subfamily 4immunitygroup A member 1\",\"id\":\"P22736\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Ribosomal protein S6 kinase beta-2\",\"id\":\"Q9UBS0\"}]", "uniprot_id": "[\"A8MYZ6\",\"O43524\",\"P22736\",\"P31749\",\"P31751\",\"P98177\",\"Q12778\",\"Q9UBS0\",\"Q9Y243\"]", "gene_symbol": "[\"AFX\",\"AFX1\",\"AKT1\",\"AKT2\",\"AKT3\",\"FKHR\",\"FKHRL1\",\"FOXO1\",\"FOXO1A\",\"FOXO3\",\"FOXO3A\",\"FOXO4\",\"FOXO6\",\"GFRP1\",\"HMR\",\"MLLT7\",\"NAK1\",\"NR4A1\",\"PKB\",\"PKBG\",\"RAC\",\"RPS6KB2\",\"STK14B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cholesterol biosynthesis", "protein_name": "[{\"label\":\"3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7\",\"id\":\"P56937\"},{\"label\":\"Acetyl-CoA acetyltransferase, cytosolic\",\"id\":\"Q9BWD1\"},{\"label\":\"Delta(14)-sterol reductase LBR\",\"id\":\"Q14739\"},{\"label\":\"Delta(14)-sterol reductase TM7SF2\",\"id\":\"O76062\"},{\"label\":\"Delta(24)-sterol reductase\",\"id\":\"Q15392\"},{\"label\":\"Diphosphomevalonate decarboxylase\",\"id\":\"P53602\"},{\"label\":\"Farnesyl pyrophosphate synthase\",\"id\":\"P14324\"},{\"label\":\"Geranylgeranyl pyrophosphate synthase\",\"id\":\"O95749\"},{\"label\":\"Hydroxymethylglutaryl-CoA synthase, cytoplasmic\",\"id\":\"Q01581\"},{\"label\":\"Isopentenyl-diphosphate Delta-isomerase 1\",\"id\":\"Q13907\"},{\"label\":\"Isopentenyl-diphosphate delta-isomerase 2\",\"id\":\"Q9BXS1\"},{\"label\":\"Lanosterol 14-alpha demethylase\",\"id\":\"Q16850\"},{\"label\":\"Lanosterol synthase\",\"id\":\"P48449\"},{\"label\":\"Methylsterol monooxygenase 1\",\"id\":\"Q15800\"},{\"label\":\"Mevalonate kinase\",\"id\":\"Q03426\"},{\"label\":\"Phosphomevalonate kinase\",\"id\":\"Q15126\"},{\"label\":\"Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6\",\"id\":\"Q8IY26\"},{\"label\":\"Protein ARV1\",\"id\":\"Q9H2C2\"},{\"label\":\"Squalene monooxygenase\",\"id\":\"Q14534\"},{\"label\":\"Squalene synthase\",\"id\":\"P37268\"},{\"label\":\"Sterol regulatory element-binding protein 1\",\"id\":\"P36956\"},{\"label\":\"Sterol regulatory element-binding protein 2\",\"id\":\"Q12772\"},{\"label\":\"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating\",\"id\":\"Q15738\"}]", "uniprot_id": "[\"O76062\",\"O95749\",\"P14324\",\"P36956\",\"P37268\",\"P48449\",\"P53602\",\"P56937\",\"Q01581\",\"Q03426\",\"Q12772\",\"Q13907\",\"Q14534\",\"Q14739\",\"Q15126\",\"Q15392\",\"Q15738\",\"Q15800\",\"Q16850\",\"Q8IY26\",\"Q9BWD1\",\"Q9BXS1\",\"Q9H2C2\"]", "gene_symbol": "[\"17HSD7\",\"ACAT2\",\"ACTL\",\"ANG1\",\"ARV1\",\"BHLHD1\",\"BHLHD2\",\"CYP51\",\"CYP51A1\",\"DESP4\",\"DHCR24\",\"ERG1\",\"ERG25\",\"FDFT1\",\"FDPS\",\"FPS\",\"GGPS1\",\"H105E3\",\"HMGCS\",\"HMGCS1\",\"HSD17B7\",\"IDI1\",\"IDI2\",\"KIAA0018\",\"KIAA1293\",\"LBR\",\"LSS\",\"MPD\",\"MSMO1\",\"MVD\",\"MVK\",\"NSDHL\",\"OSC\",\"PDP1\",\"PLPP6\",\"PMKI\",\"PMVK\",\"PPAPDC2\",\"SC4MOL\",\"SDR37C1\",\"SQLE\",\"SREBF1\",\"SREBF2\",\"SREBP1\",\"SREBP2\",\"TM7SF2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MTF1 activates gene expression", "protein_name": "[{\"label\":\"Beta-synuclein\",\"id\":\"Q16143\"},{\"label\":\"Cysteine and glycine-rich protein 1\",\"id\":\"P21291\"},{\"label\":\"Metal regulatory transcription factor 1\",\"id\":\"Q14872\"}]", "uniprot_id": "[\"P21291\",\"Q14872\",\"Q16143\"]", "gene_symbol": "[\"CSRP\",\"CSRP1\",\"CYRP\",\"MTF1\",\"SNCB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Presynaptic function of Kainate receptors", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1\",\"id\":\"Q9NQ66\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2\",\"id\":\"Q00722\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3\",\"id\":\"Q01970\"},{\"label\":\"Glutamate receptor ionotropic, kainate 3\",\"id\":\"Q13003\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O60262\",\"P16520\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63211\",\"P63215\",\"P63218\",\"Q00722\",\"Q01970\",\"Q13003\",\"Q9HAV0\",\"Q9NQ66\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": "[\"GLUR7\",\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNB5\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT1\",\"GNGT10\",\"GNGT11\",\"GNGT2\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT8\",\"GNGT9\",\"GRIK3\",\"KIAA0581\",\"PLCB1\",\"PLCB2\",\"PLCB3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Myogenesis", "protein_name": "[{\"label\":\"BCL2/adenovirus E1B 19 kDa protein-interacting protein 2\",\"id\":\"Q12982\"},{\"label\":\"C-Jun-amino-terminal kinase-interacting protein 4\",\"id\":\"O60271\"},{\"label\":\"Cadherin-15\",\"id\":\"P55291\"},{\"label\":\"Cadherin-2\",\"id\":\"P19022\"},{\"label\":\"Cadherin-4\",\"id\":\"P55283\"},{\"label\":\"Catenin alpha-1\",\"id\":\"P35221\"},{\"label\":\"Catenin alpha-2\",\"id\":\"P26232\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Cell adhesion molecule-related/down-regulated by oncogenes\",\"id\":\"Q4KMG0\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 6\",\"id\":\"P52564\"},{\"label\":\"Mitogen-activated protein kinase 11\",\"id\":\"Q15759\"},{\"label\":\"Mitogen-activated protein kinase 12\",\"id\":\"P53778\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Myoblast determination protein 1\",\"id\":\"P15172\"},{\"label\":\"Myocyte-specific enhancer factor 2A\",\"id\":\"Q02078\"},{\"label\":\"Myocyte-specific enhancer factor 2B\",\"id\":\"Q02080\"},{\"label\":\"Myocyte-specific enhancer factor 2C\",\"id\":\"Q06413\"},{\"label\":\"Myocyte-specific enhancer factor 2D\",\"id\":\"Q14814\"},{\"label\":\"Myogenic factor 5\",\"id\":\"P13349\"},{\"label\":\"Myogenic factor 6\",\"id\":\"P23409\"},{\"label\":\"Myogenin\",\"id\":\"P15173\"},{\"label\":\"Neogenin\",\"id\":\"Q92859\"},{\"label\":\"Netrin-3\",\"id\":\"O00634\"},{\"label\":\"Transcription factor 12\",\"id\":\"Q99081\"},{\"label\":\"Transcription factor 4\",\"id\":\"P15884\"},{\"label\":\"Transcription factor E2-alpha\",\"id\":\"P15923\"},{\"label\":\"Tyrosine-protein kinase ABL1\",\"id\":\"P00519\"}]", "uniprot_id": 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receptor type-2B\",\"id\":\"Q13705\"},{\"label\":\"Anti-Muellerian hormone type-2 receptor\",\"id\":\"Q16671\"},{\"label\":\"Bone morphogenetic protein 10\",\"id\":\"O95393\"},{\"label\":\"Bone morphogenetic protein 2\",\"id\":\"P12643\"},{\"label\":\"Bone morphogenetic protein receptor type-1A\",\"id\":\"P36894\"},{\"label\":\"Bone morphogenetic protein receptor type-1B\",\"id\":\"O00238\"},{\"label\":\"Bone morphogenetic protein receptor type-2\",\"id\":\"Q13873\"},{\"label\":\"Cerberus\",\"id\":\"O95813\"},{\"label\":\"Chordin-like protein 1\",\"id\":\"Q9BU40\"},{\"label\":\"E3 ubiquitin-protein ligase SMURF1\",\"id\":\"Q9HCE7\"},{\"label\":\"E3 ubiquitin-protein ligase SMURF2\",\"id\":\"Q9HAU4\"},{\"label\":\"Follistatin-related protein 1\",\"id\":\"Q12841\"},{\"label\":\"Gremlin-2\",\"id\":\"Q9H772\"},{\"label\":\"Growth/differentiation factor 2\",\"id\":\"Q9UK05\"},{\"label\":\"Inhibin alpha chain\",\"id\":\"P05111\"},{\"label\":\"Inhibin beta A chain\",\"id\":\"P08476\"},{\"label\":\"Mothers against decapentaplegic homolog 1\",\"id\":\"Q15797\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"Mothers against decapentaplegic homolog 5\",\"id\":\"Q99717\"},{\"label\":\"Mothers against decapentaplegic homolog 6\",\"id\":\"O43541\"},{\"label\":\"Mothers against decapentaplegic homolog 7\",\"id\":\"O15105\"},{\"label\":\"Mothers against decapentaplegic homolog 9\",\"id\":\"O15198\"},{\"label\":\"Muellerian-inhibiting factor\",\"id\":\"P03971\"},{\"label\":\"Noggin\",\"id\":\"Q13253\"},{\"label\":\"Ski oncogene\",\"id\":\"P12755\"},{\"label\":\"Transforming growth factor beta receptor type 3\",\"id\":\"Q03167\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D3\",\"id\":\"P61077\"},{\"label\":\"Zinc finger FYVE domain-containing protein 16\",\"id\":\"Q7Z3T8\"}]", "uniprot_id": "[\"O00238\",\"O15105\",\"O15198\",\"O43541\",\"O95393\",\"O95813\",\"P03971\",\"P05111\",\"P08476\",\"P12643\",\"P12755\",\"P27037\",\"P36894\",\"P37023\",\"P51668\",\"P61077\",\"Q03167\",\"Q12841\",\"Q13253\",\"Q13485\",\"Q13705\",\"Q13873\",\"Q15797\",\"Q16671\",\"Q7Z3T8\",\"Q99717\",\"Q9BU40\",\"Q9H772\",\"Q9HAU4\",\"Q9HCE7\",\"Q9UK05\"]", "gene_symbol": "[\"ACVR2\",\"ACVR2A\",\"ACVR2B\",\"ACVRL1\",\"ACVRLK1\",\"ACVRLK3\",\"ALK1\",\"ALK3\",\"AMH\",\"AMHR\",\"AMHR2\",\"BMP10\",\"BMP2\",\"BMP2A\",\"BMP9\",\"BMPR1A\",\"BMPR1B\",\"BMPR2\",\"BSP1\",\"CER1\",\"CHRDL1\",\"CKTSF1B2\",\"DAND3\",\"DAND4\",\"DPC4\",\"FRP\",\"FSTL1\",\"GDF2\",\"GREM2\",\"INHA\",\"INHBA\",\"KIAA0305\",\"KIAA1625\",\"MADH1\",\"MADH4\",\"MADH5\",\"MADH6\",\"MADH7\",\"MADH8\",\"MADH9\",\"MADR1\",\"MIF\",\"MISR2\",\"NOG\",\"NRLN1\",\"PPH1\",\"PRDC\",\"SFT\",\"SKI\",\"SMAD1\",\"SMAD4\",\"SMAD5\",\"SMAD6\",\"SMAD7\",\"SMAD8\",\"SMAD9\",\"SMURF1\",\"SMURF2\",\"TGFBR3\",\"UBC5A\",\"UBC5C\",\"UBCH5\",\"UBCH5A\",\"UBCH5C\",\"UBE2D1\",\"UBE2D3\",\"ZFYVE16\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)", "protein_name": "[{\"label\":\"Sodium/potassium/calcium exchanger 4\",\"id\":\"Q8NFF2\"}]", "uniprot_id": "[\"Q8NFF2\"]", "gene_symbol": "[\"NCKX4\",\"SLC24A4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SUMOylation of nuclear envelope proteins", "protein_name": "[{\"label\":\"Ran GTPase-activating protein 1\",\"id\":\"P46060\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"}]", "uniprot_id": "[\"P46060\",\"P63165\",\"P63279\"]", "gene_symbol": "[\"KIAA1835\",\"RANGAP1\",\"SD\",\"SMT3C\",\"SMT3H3\",\"SUMO1\",\"UBC9\",\"UBCE9\",\"UBE2I\",\"UBL1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PKA-mediated phosphorylation of key metabolic factors", "protein_name": "[{\"label\":\"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1\",\"id\":\"P16118\"},{\"label\":\"Carbohydrate-responsive element-binding protein\",\"id\":\"Q9NP71\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": "[\"P16118\",\"P17612\",\"P22612\",\"P22694\",\"Q9NP71\"]", "gene_symbol": "[\"BHLHD14\",\"F6PK\",\"MIO\",\"MLXIPL\",\"PFKFB1\",\"PFRX\",\"PKACA\",\"PRKACA\",\"PRKACB\",\"PRKACG\",\"WBSCR14\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G alpha (12/13) signalling events", "protein_name": "[{\"label\":\"A-kinase anchor protein 13\",\"id\":\"Q12802\"},{\"label\":\"Active breakpoint cluster region-related protein\",\"id\":\"Q12979\"},{\"label\":\"Alpha-1A adrenergic receptor\",\"id\":\"P35348\"},{\"label\":\"Alpha-1B adrenergic receptor\",\"id\":\"P35368\"},{\"label\":\"Alpha-1D adrenergic receptor\",\"id\":\"P25100\"},{\"label\":\"Ephexin-1\",\"id\":\"Q8N5V2\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 1\",\"id\":\"P98174\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 2\",\"id\":\"Q7Z6J4\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 3\",\"id\":\"Q5JSP0\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 4\",\"id\":\"Q96M96\"},{\"label\":\"Guanine nucleotide exchange factor DBS\",\"id\":\"O15068\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Guanine nucleotide exchange factor VAV3\",\"id\":\"Q9UKW4\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-12\",\"id\":\"Q03113\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-13\",\"id\":\"Q14344\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Intersectin-1\",\"id\":\"Q15811\"},{\"label\":\"Kalirin\",\"id\":\"O60229\"},{\"label\":\"Neuroepithelial cell-transforming gene 1 protein\",\"id\":\"Q7Z628\"},{\"label\":\"Obscurin\",\"id\":\"Q5VST9\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Pleckstrin homology domain-containing family G member 2\",\"id\":\"Q9H7P9\"},{\"label\":\"Pleckstrin homology domain-containing family G member 5\",\"id\":\"O94827\"},{\"label\":\"Plexin-B1\",\"id\":\"O43157\"},{\"label\":\"Protein ECT2\",\"id\":\"Q9H8V3\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"Ras-specific guanine nucleotide-releasing factor 2\",\"id\":\"O14827\"},{\"label\":\"Rho guanine nucleotide exchange factor 10-like protein\",\"id\":\"Q9HCE6\"},{\"label\":\"Rho guanine nucleotide exchange factor 10\",\"id\":\"O15013\"},{\"label\":\"Rho guanine nucleotide exchange factor 11\",\"id\":\"O15085\"},{\"label\":\"Rho guanine nucleotide exchange factor 12\",\"id\":\"Q9NZN5\"},{\"label\":\"Rho guanine nucleotide exchange factor 15\",\"id\":\"O94989\"},{\"label\":\"Rho guanine nucleotide exchange factor 16\",\"id\":\"Q5VV41\"},{\"label\":\"Rho guanine nucleotide exchange factor 17\",\"id\":\"Q96PE2\"},{\"label\":\"Rho guanine nucleotide exchange factor 18\",\"id\":\"Q6ZSZ5\"},{\"label\":\"Rho guanine nucleotide exchange factor 19\",\"id\":\"Q8IW93\"},{\"label\":\"Rho guanine nucleotide exchange factor 1\",\"id\":\"Q92888\"},{\"label\":\"Rho guanine nucleotide exchange factor 26\",\"id\":\"Q96DR7\"},{\"label\":\"Rho guanine nucleotide exchange factor 2\",\"id\":\"Q92974\"},{\"label\":\"Rho guanine nucleotide exchange factor 33\",\"id\":\"A8MVX0\"},{\"label\":\"Rho guanine nucleotide exchange factor 35\",\"id\":\"A5YM69\"},{\"label\":\"Rho guanine nucleotide exchange factor 37\",\"id\":\"A1IGU5\"},{\"label\":\"Rho guanine nucleotide exchange factor 38\",\"id\":\"Q9NXL2\"},{\"label\":\"Rho guanine nucleotide exchange factor 39\",\"id\":\"Q8N4T4\"},{\"label\":\"Rho guanine nucleotide exchange factor 3\",\"id\":\"Q9NR81\"},{\"label\":\"Rho guanine nucleotide exchange factor 40\",\"id\":\"Q8TER5\"},{\"label\":\"Rho guanine nucleotide exchange factor 4\",\"id\":\"Q9NR80\"},{\"label\":\"Rho guanine nucleotide exchange factor 5\",\"id\":\"Q12774\"},{\"label\":\"Rho guanine nucleotide exchange factor 6\",\"id\":\"Q15052\"},{\"label\":\"Rho guanine nucleotide exchange factor 7\",\"id\":\"Q14155\"},{\"label\":\"Rho guanine nucleotide exchange factor 9\",\"id\":\"O43307\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM1\",\"id\":\"Q13009\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM2\",\"id\":\"Q8IVF5\"},{\"label\":\"Rho-associated protein kinase 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"gtc_id": "[\"\"]" }, { "pathway_label": "GSD XV", "protein_name": "[{\"label\":\"Glycogen [starch] synthase, muscle\",\"id\":\"P13807\"},{\"label\":\"Glycogenin-1\",\"id\":\"P46976\"}]", "uniprot_id": "[\"P13807\",\"P46976\"]", "gene_symbol": "[\"GYG\",\"GYG1\",\"GYS\",\"GYS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Gap-filling DNA repair synthesis and ligation in GG-NER", "protein_name": "[{\"label\":\"DNA ligase 1\",\"id\":\"P18858\"},{\"label\":\"DNA ligase 3\",\"id\":\"P49916\"},{\"label\":\"DNA polymerase delta catalytic subunit\",\"id\":\"P28340\"},{\"label\":\"DNA polymerase delta subunit 2\",\"id\":\"P49005\"},{\"label\":\"DNA polymerase delta subunit 3\",\"id\":\"Q15054\"},{\"label\":\"DNA polymerase delta subunit 4\",\"id\":\"Q9HCU8\"},{\"label\":\"DNA polymerase epsilon catalytic subunit A\",\"id\":\"Q07864\"},{\"label\":\"DNA polymerase epsilon subunit 2\",\"id\":\"P56282\"},{\"label\":\"DNA polymerase epsilon subunit 3\",\"id\":\"Q9NRF9\"},{\"label\":\"DNA 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protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"P0CG47\",\"P0CG48\",\"P12004\",\"P15927\",\"P18858\",\"P18887\",\"P27694\",\"P28340\",\"P35244\",\"P35249\",\"P35250\",\"P35251\",\"P40937\",\"P40938\",\"P49005\",\"P49916\",\"P56282\",\"P62979\",\"P62987\",\"Q07864\",\"Q15054\",\"Q9HCU8\",\"Q9NR33\",\"Q9NRF9\",\"Q9UBT6\"]", "gene_symbol": "[\"CHRAC17\",\"DINB1\",\"DPE2\",\"KIAA0039\",\"LIG1\",\"LIG3\",\"PCNA\",\"POLD\",\"POLD1\",\"POLD2\",\"POLD3\",\"POLD4\",\"POLDS\",\"POLE\",\"POLE1\",\"POLE2\",\"POLE3\",\"POLE4\",\"POLK\",\"REPA1\",\"REPA2\",\"REPA3\",\"RFC1\",\"RFC140\",\"RFC2\",\"RFC3\",\"RFC4\",\"RFC5\",\"RPA1\",\"RPA14\",\"RPA2\",\"RPA3\",\"RPA32\",\"RPA34\",\"RPA70\",\"RPS27A\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"XRCC1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Rev-mediated nuclear export of HIV RNA", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase 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4\",\"id\":\"Q14839\"},{\"label\":\"DNA excision repair protein ERCC-6\",\"id\":\"Q03468\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H3.3\",\"id\":\"P84243\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone deacetylase 2\",\"id\":\"Q92769\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Histone-binding protein RBBP7\",\"id\":\"Q16576\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT2\",\"id\":\"Q96KQ7\"},{\"label\":\"Metastasis-associated protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Dual Incision in GG-NER", "protein_name": "[{\"label\":\"Chromodomain-helicase-DNA-binding protein 1-like\",\"id\":\"Q86WJ1\"},{\"label\":\"Cullin-4A\",\"id\":\"Q13619\"},{\"label\":\"Cullin-4B\",\"id\":\"Q13620\"},{\"label\":\"DNA damage-binding protein 1\",\"id\":\"Q16531\"},{\"label\":\"DNA damage-binding protein 2\",\"id\":\"Q92466\"},{\"label\":\"DNA excision repair protein ERCC-1\",\"id\":\"P07992\"},{\"label\":\"DNA excision repair protein ERCC-5\",\"id\":\"P28715\"},{\"label\":\"DNA polymerase delta catalytic subunit\",\"id\":\"P28340\"},{\"label\":\"DNA polymerase delta subunit 2\",\"id\":\"P49005\"},{\"label\":\"DNA polymerase delta subunit 3\",\"id\":\"Q15054\"},{\"label\":\"DNA polymerase delta subunit 4\",\"id\":\"Q9HCU8\"},{\"label\":\"DNA polymerase epsilon catalytic subunit A\",\"id\":\"Q07864\"},{\"label\":\"DNA polymerase epsilon subunit 2\",\"id\":\"P56282\"},{\"label\":\"DNA polymerase epsilon subunit 3\",\"id\":\"Q9NRF9\"},{\"label\":\"DNA polymerase epsilon subunit 4\",\"id\":\"Q9NR33\"},{\"label\":\"DNA polymerase kappa\",\"id\":\"Q9UBT6\"},{\"label\":\"DNA repair endonuclease XPF\",\"id\":\"Q92889\"},{\"label\":\"DNA repair protein complementing XP-A cells\",\"id\":\"P23025\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Poly [ADP-ribose] polymerase 1\",\"id\":\"P09874\"},{\"label\":\"Poly [ADP-ribose] polymerase 2\",\"id\":\"Q9UGN5\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Replication factor C subunit 1\",\"id\":\"P35251\"},{\"label\":\"Replication factor C subunit 2\",\"id\":\"P35250\"},{\"label\":\"Replication factor C subunit 3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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1\",\"id\":\"O14727\"},{\"label\":\"Caspase-3\",\"id\":\"P42574\"},{\"label\":\"Caspase-7\",\"id\":\"P55210\"},{\"label\":\"Caspase-9\",\"id\":\"P55211\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"Diablo IAP-binding mitochondrial protein\",\"id\":\"Q9NR28\"},{\"label\":\"E3 ubiquitin-protein ligase XIAP\",\"id\":\"P98170\"}]", "uniprot_id": "[\"O14727\",\"P42574\",\"P55210\",\"P55211\",\"P98170\",\"P99999\",\"Q9NR28\"]", "gene_symbol": "[\"APAF1\",\"API3\",\"BIRC4\",\"CASP3\",\"CASP7\",\"CASP9\",\"CPP32\",\"CYC\",\"CYCS\",\"DIABLO\",\"IAP3\",\"KIAA0413\",\"MCH3\",\"MCH6\",\"SMAC\",\"XIAP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "sunitinib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TRAF6 mediated NF-kB activation", "protein_name": "[{\"label\":\"Advanced glycosylation end product-specific receptor\",\"id\":\"Q15109\"},{\"label\":\"Amyloid-beta precursor protein\",\"id\":\"P05067\"},{\"label\":\"Antiviral innate immune response receptor RIG-I\",\"id\":\"O95786\"},{\"label\":\"E3 ubiquitin-protein ligase RNF135\",\"id\":\"Q8IUD6\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM4\",\"id\":\"Q9C037\"},{\"label\":\"E3 ubiquitin/ISG15 ligase TRIM25\",\"id\":\"Q14258\"},{\"label\":\"High mobility group protein B1\",\"id\":\"P09429\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Interferon-induced helicase C domain-containing protein 1\",\"id\":\"Q9BYX4\"},{\"label\":\"Mitochondrial antiviral-signaling protein\",\"id\":\"Q7Z434\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 1\",\"id\":\"Q13233\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"NF-kappa-B inhibitor alpha\",\"id\":\"P25963\"},{\"label\":\"NF-kappa-B inhibitor beta\",\"id\":\"Q15653\"},{\"label\":\"NF-kappa-B inhibitor-interacting Ras-like protein 1\",\"id\":\"Q9NYS0\"},{\"label\":\"NF-kappa-B inhibitor-interacting Ras-like protein 2\",\"id\":\"Q9NYR9\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Protein S100-A12\",\"id\":\"P80511\"},{\"label\":\"Protein S100-B\",\"id\":\"P04271\"},{\"label\":\"Serum amyloid A-1 protein\",\"id\":\"P0DJI8\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": 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the Golgi Apparatus", "protein_name": "[{\"label\":\"Hemagglutinin\",\"id\":\"P03452\"},{\"label\":\"Matrix protein 2\",\"id\":\"P06821\"},{\"label\":\"Neuraminidase\",\"id\":\"P03468\"}]", "uniprot_id": "[\"P03452\",\"P03468\",\"P06821\"]", "gene_symbol": "[\"HA\",\"M\",\"NA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Beta-ketothiolase deficiency", "protein_name": "[{\"label\":\"Acetyl-CoA acetyltransferase, mitochondrial\",\"id\":\"P24752\"}]", "uniprot_id": "[\"P24752\"]", "gene_symbol": "[\"ACAT\",\"ACAT1\",\"MAT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RSK activation", "protein_name": "[{\"label\":\"3-phosphoinositide-dependent protein kinase 1\",\"id\":\"O15530\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Ribosomal protein S6 kinase alpha-1\",\"id\":\"Q15418\"},{\"label\":\"Ribosomal protein S6 kinase alpha-2\",\"id\":\"Q15349\"},{\"label\":\"Ribosomal protein S6 kinase alpha-3\",\"id\":\"P51812\"},{\"label\":\"Ribosomal protein S6 kinase alpha-6\",\"id\":\"Q9UK32\"}]", "uniprot_id": "[\"O15530\",\"P27361\",\"P28482\",\"P51812\",\"Q15349\",\"Q15418\",\"Q9UK32\"]", "gene_symbol": "[\"ERK1\",\"ERK2\",\"ISPK1\",\"MAPK1\",\"MAPK3\",\"MAPKAPK1A\",\"MAPKAPK1B\",\"MAPKAPK1C\",\"PDK1\",\"PDPK1\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"RPS6KA1\",\"RPS6KA2\",\"RPS6KA3\",\"RPS6KA6\",\"RSK1\",\"RSK2\",\"RSK3\",\"RSK4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of E-series 18(S)-resolvins", "protein_name": "[{\"label\":\"15-hydroxyprostaglandin dehydrogenase [NAD(+)]\",\"id\":\"P15428\"},{\"label\":\"Leukotriene A-4 hydrolase\",\"id\":\"P09960\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"},{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX15\",\"id\":\"P16050\"}]", "uniprot_id": "[\"P09917\",\"P09960\",\"P15428\",\"P16050\"]", "gene_symbol": "[\"ALOX15\",\"ALOX5\",\"HPGD\",\"LOG15\",\"LOG5\",\"LTA4\",\"LTA4H\",\"PGDH1\",\"SDR36C1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCA1 causes TGD", "protein_name": "[{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Phospholipid-transporting ATPase ABCA1\",\"id\":\"O95477\"}]", "uniprot_id": "[\"O95477\",\"P02647\"]", "gene_symbol": "[\"ABC1\",\"ABCA1\",\"APOA1\",\"CERP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signalling to RAS", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"High affinity nerve growth factor receptor\",\"id\":\"P04629\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"SHC-transforming protein 2\",\"id\":\"P98077\"},{\"label\":\"SHC-transforming protein 3\",\"id\":\"Q92529\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P01138\",\"P04629\",\"P29353\",\"P98077\",\"Q07889\",\"Q92529\"]", "gene_symbol": "[\"HRAS\",\"HRAS1\",\"MTC\",\"NGF\",\"NGFB\",\"NRAS\",\"NSHC\",\"NTRK1\",\"SCK\",\"SHC\",\"SHC1\",\"SHC2\",\"SHC3\",\"SHCA\",\"SHCB\",\"SHCC\",\"SOS1\",\"TRK\",\"TRKA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Constitutive Signaling by Overexpressed ERBB2", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 12\",\"id\":\"Q05209\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P04626\",\"P07900\",\"P29353\",\"Q05209\",\"Q07889\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HRAS\",\"HRAS1\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\",\"NRAS\",\"PTPN12\",\"SHC\",\"SHC1\",\"SHCA\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of CDH11 function", "protein_name": "[{\"label\":\"Angiopoietin-related protein 4\",\"id\":\"Q9BY76\"},{\"label\":\"Cadherin-11\",\"id\":\"P55287\"},{\"label\":\"Catenin alpha-1\",\"id\":\"P35221\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Catenin delta-1\",\"id\":\"O60716\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 19\",\"id\":\"Q9H013\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 33\",\"id\":\"Q9BZ11\"},{\"label\":\"Junction plakoglobin\",\"id\":\"P14923\"}]", "uniprot_id": "[\"O60716\",\"P14923\",\"P35221\",\"P35222\",\"P55287\",\"Q9BY76\",\"Q9BZ11\",\"Q9H013\"]", "gene_symbol": "[\"ADAM19\",\"ADAM33\",\"ANGPTL4\",\"ARP4\",\"C20orf153\",\"CDH11\",\"CTNNA1\",\"CTNNB\",\"CTNNB1\",\"CTNND1\",\"CTNNG\",\"DP3\",\"HFARP\",\"JUP\",\"KIAA0384\",\"MLTNB\",\"PGAR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"P00533\",\"P01111\",\"P01112\",\"P01133\",\"P07900\",\"P0CG47\",\"P0CG48\",\"P19174\",\"P22681\",\"P27986\",\"P29353\",\"P42336\",\"P62979\",\"P62987\",\"Q07889\",\"Q13480\",\"Q16543\"]", "gene_symbol": "[\"CBL\",\"CBL2\",\"CDC37\",\"CDC37A\",\"EGF\",\"EGFR\",\"ERBB\",\"ERBB1\",\"GAB1\",\"GRB1\",\"HER1\",\"HRAS\",\"HRAS1\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"NRAS\",\"PIK3CA\",\"PIK3R1\",\"PLC1\",\"PLCG1\",\"RNF55\",\"RPS27A\",\"SHC\",\"SHC1\",\"SHCA\",\"SOS1\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective VWF binding to collagen type I", "protein_name": "[{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"P04275\"]", "gene_symbol": "[\"F8VWF\",\"VWF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"BRCA1-associated RING domain protein 1\",\"id\":\"Q99728\"},{\"label\":\"Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN\",\"id\":\"Q14191\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"},{\"label\":\"Breast cancer type 2 susceptibility protein\",\"id\":\"P51587\"},{\"label\":\"DNA endonuclease RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA repair protein RAD51 homolog 1\",\"id\":\"Q06609\"},{\"label\":\"DNA repair protein RAD51 homolog 2\",\"id\":\"O15315\"},{\"label\":\"DNA repair protein RAD51 homolog 3\",\"id\":\"O43502\"},{\"label\":\"DNA repair protein RAD51 homolog 4\",\"id\":\"O75771\"},{\"label\":\"DNA repair protein XRCC2\",\"id\":\"O43543\"},{\"label\":\"DNA replication ATP-dependent helicase/nuclease DNA2\",\"id\":\"P51530\"},{\"label\":\"DNA topoisomerase 3-alpha\",\"id\":\"Q13472\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Exonuclease 1\",\"id\":\"Q9UQ84\"},{\"label\":\"Fanconi anemia group J protein\",\"id\":\"Q9BX63\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"Partner and localizer of BRCA2\",\"id\":\"Q86YC2\"},{\"label\":\"RAD51-associated protein 1\",\"id\":\"Q96B01\"},{\"label\":\"RecQ-like DNA helicase BLM\",\"id\":\"P54132\"},{\"label\":\"RecQ-mediated genome instability protein 1\",\"id\":\"Q9H9A7\"},{\"label\":\"RecQ-mediated genome instability protein 2\",\"id\":\"Q96E14\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"}]", "uniprot_id": "[\"O15315\",\"O43502\",\"O43543\",\"O60934\",\"O75771\",\"P38398\",\"P49959\",\"P51530\",\"P51587\",\"P54132\",\"P60896\",\"Q06609\",\"Q13315\",\"Q13472\",\"Q14191\",\"Q86YC2\",\"Q92878\",\"Q92993\",\"Q96B01\",\"Q96E14\",\"Q99708\",\"Q99728\",\"Q9BX63\",\"Q9H9A7\",\"Q9UQ84\"]", "gene_symbol": 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16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 5\",\"id\":\"Q9UJX4\"},{\"label\":\"Anaphase-promoting complex subunit 7\",\"id\":\"Q9UJX3\"},{\"label\":\"Anaphase-promoting complex subunit CDC26\",\"id\":\"Q8NHZ8\"},{\"label\":\"CCAAT/enhancer-binding protein beta\",\"id\":\"P17676\"},{\"label\":\"Cell division cycle protein 16 homolog\",\"id\":\"Q13042\"},{\"label\":\"Cell division cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Cyclin-A1\",\"id\":\"P78396\"},{\"label\":\"Cyclin-A2\",\"id\":\"P20248\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor B\",\"id\":\"P42772\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor C\",\"id\":\"P42773\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor D\",\"id\":\"P55273\"},{\"label\":\"Cyclin-dependent kinase 4\",\"id\":\"P11802\"},{\"label\":\"Cyclin-dependent kinase 6\",\"id\":\"Q00534\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"Cyclin-dependent kinase inhibitor 2A\",\"id\":\"P42771\"},{\"label\":\"Fizzy-related protein homolog\",\"id\":\"Q9UM11\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone 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alpha-1\",\"id\":\"Q15418\"},{\"label\":\"Ribosomal protein S6 kinase alpha-2\",\"id\":\"Q15349\"},{\"label\":\"Ribosomal protein S6 kinase alpha-3\",\"id\":\"P51812\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Transcription factor Jun\",\"id\":\"P05412\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "protein_name": "[{\"label\":\"Adapter molecule crk\",\"id\":\"P46108\"},{\"label\":\"Breast cancer anti-estrogen resistance protein 1\",\"id\":\"P56945\"},{\"label\":\"Dedicator of cytokinesis protein 1\",\"id\":\"Q14185\"},{\"label\":\"Engulfment and cell motility protein 1\",\"id\":\"Q92556\"},{\"label\":\"Engulfment and cell motility protein 2\",\"id\":\"Q96JJ3\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Paxillin\",\"id\":\"P49023\"},{\"label\":\"Protein-tyrosine kinase 6\",\"id\":\"Q13882\"},{\"label\":\"Ras GTPase-activating protein 1\",\"id\":\"P20936\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"}]", "uniprot_id": "[\"P01111\",\"P01112\",\"P20936\",\"P46108\",\"P49023\",\"P56945\",\"P61586\",\"P63000\",\"Q13882\",\"Q14185\",\"Q92556\",\"Q96JJ3\",\"Q9NRY4\"]", "gene_symbol": "[\"ARH12\",\"ARHA\",\"ARHGAP35\",\"BCAR1\",\"BRK\",\"CAS\",\"CASS1\",\"CED12A\",\"CRK\",\"CRKAS\",\"DOCK1\",\"ELMO1\",\"ELMO2\",\"GAP\",\"GRF1\",\"GRLF1\",\"HRAS\",\"HRAS1\",\"KIAA0281\",\"KIAA1722\",\"KIAA1834\",\"NRAS\",\"P190A\",\"PTK6\",\"PXN\",\"RAC1\",\"RASA\",\"RASA1\",\"RHO12\",\"RHOA\",\"TC25\",\"p190ARHOGAP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SDK interactions", "protein_name": "[{\"label\":\"Protein sidekick-1\",\"id\":\"Q7Z5N4\"},{\"label\":\"Protein sidekick-2\",\"id\":\"Q58EX2\"}]", "uniprot_id": "[\"Q58EX2\",\"Q7Z5N4\"]", "gene_symbol": "[\"KIAA1514\",\"SDK1\",\"SDK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ACTH causes obesity and POMCD", "protein_name": "[{\"label\":\"Adrenocorticotropic hormone receptor\",\"id\":\"Q01718\"},{\"label\":\"Pro-opiomelanocortin\",\"id\":\"P01189\"}]", "uniprot_id": "[\"P01189\",\"Q01718\"]", "gene_symbol": "[\"ACTHR\",\"MC2R\",\"POMC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Anaphase-promoting complex subunit 10\",\"id\":\"Q9UM13\"},{\"label\":\"Anaphase-promoting complex subunit 11\",\"id\":\"Q9NYG5\"},{\"label\":\"Anaphase-promoting complex subunit 15\",\"id\":\"P60006\"},{\"label\":\"Anaphase-promoting complex subunit 16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 5\",\"id\":\"Q9UJX4\"},{\"label\":\"Anaphase-promoting complex subunit 7\",\"id\":\"Q9UJX3\"},{\"label\":\"Anaphase-promoting complex subunit CDC26\",\"id\":\"Q8NHZ8\"},{\"label\":\"Cell division cycle protein 16 homolog\",\"id\":\"Q13042\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Cell division cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Cyclin-A1\",\"id\":\"P78396\"},{\"label\":\"Cyclin-A2\",\"id\":\"P20248\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Mitotic checkpoint protein BUB3\",\"id\":\"O43684\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta\",\"id\":\"O60566\"},{\"label\":\"Mitotic spindle assembly checkpoint protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective Mismatch Repair Associated With MLH1", "protein_name": "[{\"label\":\"DNA mismatch repair protein Mlh1\",\"id\":\"P40692\"},{\"label\":\"Mismatch repair endonuclease PMS2\",\"id\":\"P54278\"}]", "uniprot_id": "[\"P40692\",\"P54278\"]", "gene_symbol": "[\"COCA2\",\"MLH1\",\"PMS2\",\"PMSL2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ERBB2 Activates PTK6 Signaling", "protein_name": "[{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Protein-tyrosine kinase 6\",\"id\":\"Q13882\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"O14511\",\"O14944\",\"P00533\",\"P01133\",\"P04626\",\"P35070\",\"P56975\",\"Q02297\",\"Q13882\",\"Q8WWG1\",\"Q99075\"]", "gene_symbol": "[\"BRK\",\"BTC\",\"DTR\",\"DTS\",\"EGF\",\"EGFR\",\"ERBB\",\"ERBB1\",\"ERBB2\",\"EREG\",\"GGF\",\"HBEGF\",\"HEGFL\",\"HER1\",\"HER2\",\"HGL\",\"HRGA\",\"MLN19\",\"NDF\",\"NEU\",\"NGL\",\"NRG1\",\"NRG2\",\"NRG3\",\"NRG4\",\"NTAK\",\"PTK6\",\"SMDF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)", "protein_name": "[{\"label\":\"Sodium-dependent phosphate transport protein 2A\",\"id\":\"Q06495\"}]", "uniprot_id": "[\"Q06495\"]", "gene_symbol": "[\"NPT2\",\"SLC17A2\",\"SLC34A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Selenoamino acid metabolism", "protein_name": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of gene expression in beta cells", "protein_name": "[{\"label\":\"DNA-binding protein RFX6\",\"id\":\"Q8HWS3\"},{\"label\":\"Forkhead box protein O1\",\"id\":\"Q12778\"},{\"label\":\"Hepatocyte nuclear factor 1-alpha\",\"id\":\"P20823\"},{\"label\":\"Hepatocyte nuclear factor 3-beta\",\"id\":\"Q9Y261\"},{\"label\":\"Hepatocyte nuclear factor 3-gamma\",\"id\":\"P55318\"},{\"label\":\"Hepatocyte nuclear factor 4-gamma\",\"id\":\"Q14541\"},{\"label\":\"Hexokinase-4\",\"id\":\"P35557\"},{\"label\":\"Homeobox protein Nkx-2.2\",\"id\":\"O95096\"},{\"label\":\"Homeobox protein Nkx-6.1\",\"id\":\"P78426\"},{\"label\":\"Insulin\",\"id\":\"P01308\"},{\"label\":\"Islet amyloid polypeptide\",\"id\":\"P10997\"},{\"label\":\"Neurogenic differentiation factor 1\",\"id\":\"Q13562\"},{\"label\":\"Paired box protein Pax-6\",\"id\":\"P26367\"},{\"label\":\"Pancreas/duodenum homeobox protein 1\",\"id\":\"P52945\"},{\"label\":\"Solute carrier family 2, 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modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"NF-kappa-B inhibitor alpha\",\"id\":\"P25963\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"P19838\",\"P25963\",\"Q00653\",\"Q04206\",\"Q9Y6K9\"]", "gene_symbol": "[\"CHUK\",\"FIP3\",\"IKBA\",\"IKBKB\",\"IKBKG\",\"IKKA\",\"IKKB\",\"LYT10\",\"MAD3\",\"NEMO\",\"NFKB1\",\"NFKB2\",\"NFKB3\",\"NFKBI\",\"NFKBIA\",\"RELA\",\"TCF16\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of AMPK downstream of NMDARs", "protein_name": "[{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-1\",\"id\":\"Q13131\"},{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-2\",\"id\":\"P54646\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-1\",\"id\":\"Q9Y478\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-2\",\"id\":\"O43741\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-1\",\"id\":\"P54619\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-2\",\"id\":\"Q9UGJ0\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-3\",\"id\":\"Q9UGI9\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase kinase 2\",\"id\":\"Q96RR4\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"}]", "uniprot_id": "[\"O43741\",\"P0DP23\",\"P54619\",\"P54646\",\"Q13131\",\"Q96RR4\",\"Q9UGI9\",\"Q9UGJ0\",\"Q9Y478\"]", "gene_symbol": "[\"AMPK\",\"AMPK1\",\"AMPK2\",\"AMPKG3\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAMKK2\",\"CAMKKB\",\"KIAA0787\",\"PRKAA1\",\"PRKAA2\",\"PRKAB1\",\"PRKAB2\",\"PRKAG1\",\"PRKAG2\",\"PRKAG3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MAPK1 (ERK2) activation", "protein_name": "[{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 2\",\"id\":\"P36507\"},{\"label\":\"Interleukin-6 receptor subunit alpha\",\"id\":\"P08887\"},{\"label\":\"Interleukin-6\",\"id\":\"P05231\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O60674\",\"P05231\",\"P08887\",\"P23458\",\"P28482\",\"P29597\",\"P36507\",\"Q06124\"]", "gene_symbol": "[\"ERK2\",\"IFNB2\",\"IL6\",\"IL6R\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"JAK2\",\"MAP2K2\",\"MAPK1\",\"MEK2\",\"MKK2\",\"PRKM1\",\"PRKM2\",\"PRKMK2\",\"PTP2C\",\"PTPN11\",\"SHPTP2\",\"TYK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by FGFR3 in disease", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 3\",\"id\":\"P22607\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O43320\",\"O76093\",\"P01111\",\"P01112\",\"P05230\",\"P08620\",\"P09038\",\"P19174\",\"P22607\",\"P27986\",\"P31371\",\"P42336\",\"Q07889\",\"Q13480\",\"Q8WU20\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF16\",\"FGF18\",\"FGF2\",\"FGF20\",\"FGF23\",\"FGF4\",\"FGF9\",\"FGFA\",\"FGFB\",\"FGFR3\",\"FRS2\",\"GAB1\",\"GRB1\",\"HRAS\",\"HRAS1\",\"HST\",\"HSTF1\",\"HYPF\",\"JTK4\",\"KS3\",\"NRAS\",\"PIK3CA\",\"PIK3R1\",\"PLC1\",\"PLCG1\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Alpha-defensins", "protein_name": "[{\"label\":\"Defensin alpha 4\",\"id\":\"P12838\"},{\"label\":\"Defensin alpha 5\",\"id\":\"Q01523\"},{\"label\":\"Defensin-6\",\"id\":\"Q01524\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04578\"},{\"label\":\"GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1\",\"id\":\"P52961\"},{\"label\":\"Neutrophil defensin 1\",\"id\":\"P59665\"},{\"label\":\"Neutrophil defensin 3\",\"id\":\"P59666\"},{\"label\":\"T-cell surface glycoprotein CD4\",\"id\":\"P01730\"},{\"label\":\"Trypsin-2\",\"id\":\"P07478\"},{\"label\":\"Trypsin-3\",\"id\":\"P35030\"}]", "uniprot_id": "[\"P01730\",\"P04578\",\"P07478\",\"P12838\",\"P35030\",\"P52961\",\"P59665\",\"P59666\",\"Q01523\",\"Q01524\"]", "gene_symbol": "[\"ART1\",\"CD4\",\"DEF1\",\"DEF3\",\"DEF4\",\"DEF5\",\"DEF6\",\"DEFA1\",\"DEFA1B\",\"DEFA2\",\"DEFA3\",\"DEFA4\",\"DEFA5\",\"DEFA6\",\"MRS\",\"PRSS2\",\"PRSS3\",\"PRSS4\",\"TRY2\",\"TRY3\",\"TRY4\",\"TRYP2\",\"env\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Molybdenum cofactor biosynthesis", "protein_name": "[{\"label\":\"Adenylyltransferase and sulfurtransferase MOCS3\",\"id\":\"O95396\"},{\"label\":\"Gephyrin\",\"id\":\"Q9NQX3\"},{\"label\":\"Molybdenum cofactor sulfurase\",\"id\":\"Q96EN8\"},{\"label\":\"Molybdopterin synthase catalytic subunit\",\"id\":\"O96007\"},{\"label\":\"Molybdopterin synthase sulfur carrier subunit\",\"id\":\"O96033\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy", "protein_name": "[{\"label\":\"Acid ceramidase\",\"id\":\"Q13510\"},{\"label\":\"V-type proton ATPase 16 kDa proteolipid subunit c\",\"id\":\"P27449\"},{\"label\":\"V-type proton ATPase 21 kDa proteolipid subunit c''\",\"id\":\"Q99437\"},{\"label\":\"V-type proton ATPase catalytic subunit A\",\"id\":\"P38606\"},{\"label\":\"V-type proton ATPase subunit B, brain isoform\",\"id\":\"P21281\"},{\"label\":\"V-type proton ATPase subunit C 1\",\"id\":\"P21283\"},{\"label\":\"V-type proton ATPase subunit E 1\",\"id\":\"P36543\"},{\"label\":\"V-type proton ATPase subunit G 1\",\"id\":\"O75348\"},{\"label\":\"V-type proton ATPase subunit H\",\"id\":\"Q9UI12\"},{\"label\":\"V-type proton ATPase subunit d 1\",\"id\":\"P61421\"},{\"label\":\"V-type proton ATPase subunit e 1\",\"id\":\"O15342\"}]", "uniprot_id": 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"protein_name": "[{\"label\":\"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1\",\"id\":\"P16118\"},{\"label\":\"Carbohydrate-responsive element-binding protein\",\"id\":\"Q9NP71\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"P16118\",\"P30153\",\"P30154\",\"P62714\",\"P67775\",\"Q14738\",\"Q9NP71\"]", "gene_symbol": "[\"BHLHD14\",\"F6PK\",\"MIO\",\"MLXIPL\",\"PFKFB1\",\"PFRX\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5D\",\"WBSCR14\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Gastrin-CREB signalling pathway via PKC and MAPK", "protein_name": "[{\"label\":\"Gastrin/cholecystokinin type B receptor\",\"id\":\"P32239\"},{\"label\":\"Gastrin\",\"id\":\"P01350\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Mitogen-activated protein kinase 7\",\"id\":\"Q13164\"},{\"label\":\"Ribosomal protein S6 kinase alpha-1\",\"id\":\"Q15418\"},{\"label\":\"Ribosomal protein S6 kinase alpha-2\",\"id\":\"Q15349\"},{\"label\":\"Ribosomal protein S6 kinase alpha-3\",\"id\":\"P51812\"}]", "uniprot_id": "[\"P01350\",\"P27361\",\"P28482\",\"P32239\",\"P51812\",\"Q13164\",\"Q15349\",\"Q15418\"]", "gene_symbol": "[\"BMK1\",\"CCKBR\",\"CCKRB\",\"ERK1\",\"ERK2\",\"ERK5\",\"GAS\",\"GAST\",\"ISPK1\",\"MAPK1\",\"MAPK3\",\"MAPK7\",\"MAPKAPK1A\",\"MAPKAPK1B\",\"MAPKAPK1C\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"PRKM7\",\"RPS6KA1\",\"RPS6KA2\",\"RPS6KA3\",\"RSK1\",\"RSK2\",\"RSK3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "protein_name": "[{\"label\":\"Apoptosis facilitator Bcl-2-like protein 14\",\"id\":\"Q9BZR8\"},{\"label\":\"Apoptosis-stimulating of p53 protein 1\",\"id\":\"Q96KQ4\"},{\"label\":\"Apoptosis-stimulating of p53 protein 2\",\"id\":\"Q13625\"},{\"label\":\"B-cell lymphoma 6 protein\",\"id\":\"P41182\"},{\"label\":\"Baculoviral IAP repeat-containing protein 5\",\"id\":\"O15392\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Geranylgeranyl transferase type-2 subunit alpha\",\"id\":\"Q92696\"},{\"label\":\"Geranylgeranyl transferase type-2 subunit beta\",\"id\":\"P53611\"},{\"label\":\"Protein NDRG1\",\"id\":\"Q92597\"},{\"label\":\"Quinone oxidoreductase PIG3\",\"id\":\"Q53FA7\"},{\"label\":\"Rab proteins geranylgeranyltransferase component A 1\",\"id\":\"P24386\"},{\"label\":\"Tumor protein 63\",\"id\":\"Q9H3D4\"},{\"label\":\"Tumor protein p73\",\"id\":\"O15350\"},{\"label\":\"p53 apoptosis effector related to PMP-22\",\"id\":\"Q96FX8\"}]", "uniprot_id": "[\"O15350\",\"O15392\",\"P04637\",\"P24386\",\"P41182\",\"P53611\",\"Q13625\",\"Q53FA7\",\"Q92597\",\"Q92696\",\"Q96FX8\",\"Q96KQ4\",\"Q9BZR8\",\"Q9H3D4\"]", "gene_symbol": 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RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA repair protein XRCC4\",\"id\":\"Q13426\"},{\"label\":\"DNA-dependent protein kinase catalytic subunit\",\"id\":\"P78527\"},{\"label\":\"DNA-directed DNA/RNA polymerase mu\",\"id\":\"Q9NP87\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"E3 SUMO-protein ligase PIAS4\",\"id\":\"Q8N2W9\"},{\"label\":\"E3 ubiquitin-protein ligase HERC2\",\"id\":\"O95714\"},{\"label\":\"E3 ubiquitin-protein ligase RNF168\",\"id\":\"Q8IYW5\"},{\"label\":\"E3 ubiquitin-protein ligase RNF8\",\"id\":\"O76064\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1t\",\"id\":\"Q16695\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Histone-lysine N-methyltransferase NSD2\",\"id\":\"O96028\"},{\"label\":\"Lys-63-specific deubiquitinase BRCC36\",\"id\":\"P46736\"},{\"label\":\"Mediator of DNA damage checkpoint protein 1\",\"id\":\"Q14676\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"Non-homologous end-joining factor 1\",\"id\":\"Q9H9Q4\"},{\"label\":\"PAX-interacting protein 1\",\"id\":\"Q6ZW49\"},{\"label\":\"Protein artemis\",\"id\":\"Q96SD1\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"TP53-binding protein 1\",\"id\":\"Q12888\"},{\"label\":\"Telomere-associated protein RIF1\",\"id\":\"Q5UIP0\"},{\"label\":\"Tyrosyl-DNA phosphodiesterase 1\",\"id\":\"Q9NUW8\"},{\"label\":\"Tyrosyl-DNA phosphodiesterase 2\",\"id\":\"O95551\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 2\",\"id\":\"Q15819\"},{\"label\":\"X-ray repair cross-complementing protein 5\",\"id\":\"P13010\"},{\"label\":\"X-ray repair cross-complementing protein 6\",\"id\":\"P12956\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective GALNT12 causes CRCS1", "protein_name": "[{\"label\":\"Mucin-12\",\"id\":\"Q9UKN1\"},{\"label\":\"Mucin-13\",\"id\":\"Q9H3R2\"},{\"label\":\"Mucin-15\",\"id\":\"Q8N387\"},{\"label\":\"Mucin-16\",\"id\":\"Q8WXI7\"},{\"label\":\"Mucin-17\",\"id\":\"Q685J3\"},{\"label\":\"Mucin-19\",\"id\":\"Q7Z5P9\"},{\"label\":\"Mucin-1\",\"id\":\"P15941\"},{\"label\":\"Mucin-20\",\"id\":\"Q8N307\"},{\"label\":\"Mucin-21\",\"id\":\"Q5SSG8\"},{\"label\":\"Mucin-2\",\"id\":\"Q02817\"},{\"label\":\"Mucin-3A\",\"id\":\"Q02505\"},{\"label\":\"Mucin-3B\",\"id\":\"Q9H195\"},{\"label\":\"Mucin-4\",\"id\":\"Q99102\"},{\"label\":\"Mucin-5AC\",\"id\":\"P98088\"},{\"label\":\"Mucin-5B\",\"id\":\"Q9HC84\"},{\"label\":\"Mucin-6\",\"id\":\"Q6W4X9\"},{\"label\":\"Mucin-7\",\"id\":\"Q8TAX7\"},{\"label\":\"Mucin-like protein 1\",\"id\":\"Q96DR8\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 12\",\"id\":\"Q8IXK2\"}]", "uniprot_id": "[\"P15941\",\"P98088\",\"Q02505\",\"Q02817\",\"Q5SSG8\",\"Q685J3\",\"Q6W4X9\",\"Q7Z5P9\",\"Q8IXK2\",\"Q8N307\",\"Q8N387\",\"Q8TAX7\",\"Q8WXI7\",\"Q96DR8\",\"Q99102\",\"Q9H195\",\"Q9H3R2\",\"Q9HC84\",\"Q9UKN1\"]", "gene_symbol": "[\"C6orf205\",\"CA125\",\"DRCC1\",\"GALNT12\",\"KIAA1359\",\"MG2\",\"MUC1\",\"MUC11\",\"MUC12\",\"MUC13\",\"MUC15\",\"MUC16\",\"MUC17\",\"MUC19\",\"MUC2\",\"MUC20\",\"MUC21\",\"MUC3\",\"MUC3A\",\"MUC3B\",\"MUC4\",\"MUC5\",\"MUC5AC\",\"MUC5B\",\"MUC6\",\"MUC7\",\"MUCL1\",\"PUM\",\"RECC\",\"SBEM\",\"SMUC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX2 regulates chondrocyte maturation", "protein_name": "[{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"Histone deacetylase 4\",\"id\":\"P56524\"},{\"label\":\"Indian hedgehog protein\",\"id\":\"Q14623\"},{\"label\":\"Zinc finger protein GLI2\",\"id\":\"P10070\"}]", "uniprot_id": "[\"P10070\",\"P56524\",\"Q13951\",\"Q14623\"]", "gene_symbol": "[\"CBFB\",\"GLI2\",\"HDAC4\",\"IHH\",\"KIAA0288\",\"THP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2", "protein_name": "[{\"label\":\"Dystroglycan 1\",\"id\":\"Q14118\"},{\"label\":\"Protein O-mannosyl-transferase 1\",\"id\":\"Q9Y6A1\"},{\"label\":\"Protein O-mannosyl-transferase 2\",\"id\":\"Q9UKY4\"}]", "uniprot_id": "[\"Q14118\",\"Q9UKY4\",\"Q9Y6A1\"]", "gene_symbol": "[\"DAG1\",\"POMT1\",\"POMT2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Processing of SMDT1", "protein_name": "[{\"label\":\"ATP-dependent zinc metalloprotease YME1L1\",\"id\":\"Q96TA2\"},{\"label\":\"Calcium uniporter protein, mitochondrial\",\"id\":\"Q8NE86\"},{\"label\":\"Calcium uniporter regulatory subunit MCUb, mitochondrial\",\"id\":\"Q9NWR8\"},{\"label\":\"Calcium uptake protein 1, mitochondrial\",\"id\":\"Q9BPX6\"},{\"label\":\"Calcium uptake protein 2, mitochondrial\",\"id\":\"Q8IYU8\"},{\"label\":\"Calcium uptake protein 3, mitochondrial\",\"id\":\"Q86XE3\"},{\"label\":\"Essential MCU regulator, mitochondrial\",\"id\":\"Q9H4I9\"},{\"label\":\"Mitochondrial inner membrane m-AAA protease component AFG3L2\",\"id\":\"Q9Y4W6\"},{\"label\":\"Mitochondrial inner membrane m-AAA protease component paraplegin\",\"id\":\"Q9UQ90\"},{\"label\":\"Mitochondrial-processing peptidase subunit alpha\",\"id\":\"Q10713\"},{\"label\":\"Mitochondrial-processing peptidase subunit beta\",\"id\":\"O75439\"},{\"label\":\"Presenilin-associated rhomboid-like protein, mitochondrial\",\"id\":\"Q9H300\"},{\"label\":\"Prohibitin 1\",\"id\":\"P35232\"},{\"label\":\"Prohibitin-2\",\"id\":\"Q99623\"},{\"label\":\"Stomatin-like protein 2, mitochondrial\",\"id\":\"Q9UJZ1\"},{\"label\":\"m-AAA protease-interacting protein 1, mitochondrial\",\"id\":\"Q8WWC4\"}]", "uniprot_id": 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2\",\"id\":\"Q99967\"},{\"label\":\"Endothelial PAS domain-containing protein 1\",\"id\":\"Q99814\"},{\"label\":\"Erythropoietin\",\"id\":\"P01588\"},{\"label\":\"HIG1 domain family member 1A, mitochondrial\",\"id\":\"Q9Y241\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Hypoxia-inducible factor 1-alpha\",\"id\":\"Q16665\"},{\"label\":\"Vascular endothelial growth factor A, long form\",\"id\":\"P15692\"}]", "uniprot_id": "[\"P01588\",\"P15692\",\"P27540\",\"Q09472\",\"Q16665\",\"Q16790\",\"Q92793\",\"Q99814\",\"Q99967\",\"Q9Y241\"]", "gene_symbol": "[\"ARNT\",\"BHLHE2\",\"BHLHE73\",\"BHLHE78\",\"CA9\",\"CBP\",\"CITED2\",\"CREBBP\",\"EP300\",\"EPAS1\",\"EPO\",\"G250\",\"HIF1A\",\"HIF2A\",\"HIG1\",\"HIGD1A\",\"MN\",\"MOP1\",\"MOP2\",\"MRG1\",\"P300\",\"PASD2\",\"PASD8\",\"VEGF\",\"VEGFA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective cofactor function of FVIIIa variant", "protein_name": "[{\"label\":\"Coagulation factor 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glycoprotein\",\"id\":\"P20916\"},{\"label\":\"NGFI-A-binding protein 1\",\"id\":\"Q13506\"},{\"label\":\"NGFI-A-binding protein 2\",\"id\":\"Q15742\"},{\"label\":\"POU domain, class 3, transcription factor 1\",\"id\":\"Q03052\"},{\"label\":\"POU domain, class 3, transcription factor 2\",\"id\":\"P20265\"},{\"label\":\"Periaxin\",\"id\":\"Q9BXM0\"},{\"label\":\"Peripheral myelin protein 22\",\"id\":\"Q01453\"},{\"label\":\"Stearoyl-CoA desaturase 5\",\"id\":\"Q86SK9\"},{\"label\":\"Sterol regulatory element-binding protein 2\",\"id\":\"Q12772\"},{\"label\":\"Transcription activator BRG1\",\"id\":\"P51532\"},{\"label\":\"Transcription factor SOX-10\",\"id\":\"P56693\"},{\"label\":\"Transcriptional coactivator YAP1\",\"id\":\"P46937\"},{\"label\":\"Transcriptional enhancer factor TEF-1\",\"id\":\"P28347\"},{\"label\":\"Utrophin\",\"id\":\"P46939\"},{\"label\":\"WW domain-containing transcription regulator protein 1\",\"id\":\"Q9GZV5\"}]", "uniprot_id": 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"pathway_label": "Toll Like Receptor 9 (TLR9) Cascade", "protein_name": "[{\"label\":\"Early endosome antigen 1\",\"id\":\"Q15075\"},{\"label\":\"Phosphatidylinositol 3-kinase catalytic subunit type 3\",\"id\":\"Q8NEB9\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 4\",\"id\":\"Q99570\"},{\"label\":\"Rabenosyn-5\",\"id\":\"Q9H1K0\"},{\"label\":\"Toll-like receptor 9\",\"id\":\"Q9NR96\"}]", "uniprot_id": "[\"Q15075\",\"Q8NEB9\",\"Q99570\",\"Q9H1K0\",\"Q9NR96\"]", "gene_symbol": "[\"EEA1\",\"PIK3C3\",\"PIK3R4\",\"RBSN\",\"TLR9\",\"VPS15\",\"VPS34\",\"ZFYVE2\",\"ZFYVE20\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signal attenuation", "protein_name": "[{\"label\":\"Growth factor receptor-bound protein 10\",\"id\":\"Q13322\"},{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Insulin receptor\",\"id\":\"P06213\"},{\"label\":\"Insulin\",\"id\":\"P01308\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"P01308\",\"P06213\",\"P27361\",\"P28482\",\"P29353\",\"P35568\",\"Q07889\",\"Q13322\",\"Q9Y4H2\"]", "gene_symbol": "[\"ERK1\",\"ERK2\",\"GRB10\",\"GRBIR\",\"INS\",\"INSR\",\"IRS1\",\"IRS2\",\"KIAA0207\",\"MAPK1\",\"MAPK3\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"SHC\",\"SHC1\",\"SHCA\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)", "protein_name": "[{\"label\":\"Vesicular glutamate transporter 3\",\"id\":\"Q8NDX2\"}]", "uniprot_id": "[\"Q8NDX2\"]", "gene_symbol": "[\"SLC17A8\",\"VGLUT3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Degradation of GLI2 by the proteasome", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Casein kinase I isoform alpha\",\"id\":\"P48729\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"Suppressor of fused homolog\",\"id\":\"Q9UMX1\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Zinc finger protein GLI2\",\"id\":\"P10070\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": "[\"O00231\",\"O00232\",\"O00487\",\"O14818\",\"O43242\",\"P0CG47\",\"P0CG48\",\"P10070\",\"P17612\",\"P17980\",\"P20618\",\"P22612\",\"P22694\",\"P25786\",\"P25787\",\"P25788\",\"P25789\",\"P28066\",\"P28070\",\"P28072\",\"P28074\",\"P35998\",\"P43686\",\"P48556\",\"P48729\",\"P49720\",\"P49721\",\"P49841\",\"P51665\",\"P60896\",\"P60900\",\"P62191\",\"P62195\",\"P62333\",\"P62877\",\"P62979\",\"P62987\",\"P63208\",\"Q13200\",\"Q13616\",\"Q15008\",\"Q16186\",\"Q99436\",\"Q99460\",\"Q9UMX1\",\"Q9UNM6\",\"Q9Y297\"]", "gene_symbol": 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regulate gene expression linked to cholesterol transport and efflux", "protein_name": "[{\"label\":\"ADP-ribosylation factor-like protein 4C\",\"id\":\"P56559\"},{\"label\":\"ATP-binding cassette sub-family G member 1\",\"id\":\"P45844\"},{\"label\":\"ATP-binding cassette sub-family G member 5\",\"id\":\"Q9H222\"},{\"label\":\"ATP-binding cassette sub-family G member 8\",\"id\":\"Q9H221\"},{\"label\":\"Apolipoprotein C-I\",\"id\":\"P02654\"},{\"label\":\"Apolipoprotein C-II\",\"id\":\"P02655\"},{\"label\":\"Apolipoprotein C-IV\",\"id\":\"P55056\"},{\"label\":\"Apolipoprotein D\",\"id\":\"P05090\"},{\"label\":\"Apolipoprotein E\",\"id\":\"P02649\"},{\"label\":\"Cholesteryl ester transfer protein\",\"id\":\"P11597\"},{\"label\":\"Endonuclease/exonuclease/phosphatase family domain-containing protein 1\",\"id\":\"Q7L9B9\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"G protein pathway suppressor 2\",\"id\":\"Q13227\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Lysine-specific demethylase 3A\",\"id\":\"Q9Y4C1\"},{\"label\":\"Lysine-specific demethylase 4A\",\"id\":\"O75164\"},{\"label\":\"Lysine-specific histone demethylase 1A\",\"id\":\"O60341\"},{\"label\":\"Lysine-specific histone demethylase 2\",\"id\":\"Q8NB78\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Oxysterols receptor LXR-alpha\",\"id\":\"Q13133\"},{\"label\":\"Oxysterols receptor LXR-beta\",\"id\":\"P55055\"},{\"label\":\"Phospholipid-transporting ATPase ABCA1\",\"id\":\"O95477\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Retinoic acid receptor RXR-beta\",\"id\":\"P28702\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"}]", "uniprot_id": "[\"O15379\",\"O60341\",\"O60907\",\"O75164\",\"O75376\",\"O95477\",\"P02649\",\"P02654\",\"P02655\",\"P05090\",\"P11597\",\"P19793\",\"P28702\",\"P45844\",\"P55055\",\"P55056\",\"P56559\",\"Q09472\",\"Q13133\",\"Q13227\",\"Q15788\",\"Q7L9B9\",\"Q8NB78\",\"Q8NDV7\",\"Q9BZK7\",\"Q9H221\",\"Q9H222\",\"Q9H9G7\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9UPQ9\",\"Q9Y4C1\",\"Q9Y618\"]", "gene_symbol": "[\"ABC1\",\"ABC8\",\"ABCA1\",\"ABCG1\",\"ABCG5\",\"ABCG8\",\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"AOF1\",\"AOF2\",\"APC2\",\"APOC1\",\"APOC2\",\"APOC4\",\"APOD\",\"APOE\",\"ARL4C\",\"ARL7\",\"BHLHE74\",\"C6orf193\",\"CAGH26\",\"CERP\",\"CETP\",\"CTG26\",\"EEPD1\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"EP300\",\"GPS2\",\"HDAC3\",\"IRA1\",\"JHDM2A\",\"JHDM3A\",\"JMJD1\",\"JMJD1A\",\"JMJD2\",\"JMJD2A\",\"KDM1\",\"KDM1A\",\"KDM1B\",\"KDM3A\",\"KDM4A\",\"KIAA0601\",\"KIAA0677\",\"KIAA0742\",\"KIAA1047\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"KIAA1631\",\"KIAA1706\",\"LSD1\",\"LSD2\",\"LXRA\",\"LXRB\",\"MOV10\",\"NCOA1\",\"NCOR1\",\"NCOR2\",\"NER\",\"NR1H2\",\"NR1H3\",\"NR2B1\",\"NR2B2\",\"P300\",\"RXRA\",\"RXRB\",\"SRC1\",\"TBL1\",\"TBL1X\",\"TBL1XR1\",\"TBLR1\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\",\"TSGA\",\"UNR\",\"WHT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transport of Mature mRNA Derived from an Intronless Transcript", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Cleavage and polyadenylation specificity factor subunit 1\",\"id\":\"Q10570\"},{\"label\":\"Cleavage and polyadenylation specificity factor subunit 2\",\"id\":\"Q9P2I0\"},{\"label\":\"Cleavage and polyadenylation specificity factor subunit 3\",\"id\":\"Q9UKF6\"},{\"label\":\"Cleavage and polyadenylation specificity factor subunit 4\",\"id\":\"O95639\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Eukaryotic translation initiation factor 4E\",\"id\":\"P06730\"},{\"label\":\"Nuclear RNA export factor 1\",\"id\":\"Q9UBU9\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Pre-mRNA 3'-end-processing factor FIP1\",\"id\":\"Q6UN15\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Symplekin\",\"id\":\"Q92797\"},{\"label\":\"THO complex subunit 4\",\"id\":\"Q86V81\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"},{\"label\":\"pre-mRNA 3' end processing protein WDR33\",\"id\":\"Q9C0J8\"}]", "uniprot_id": "[\"A8CG34\",\"O15504\",\"O75694\",\"O95639\",\"P06730\",\"P12270\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P52298\",\"P55735\",\"P57740\",\"P78406\",\"Q09161\",\"Q10570\",\"Q12769\",\"Q5SRE5\",\"Q6UN15\",\"Q7Z3B4\",\"Q86V81\",\"Q8N1F7\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q92797\",\"Q96HA1\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9C0J8\",\"Q9NRG9\",\"Q9P2I0\",\"Q9UBU9\",\"Q9UKF6\",\"Q9UKX7\"]", "gene_symbol": "[\"AAAS\",\"ADRACALA\",\"ALY\",\"ALYREF\",\"BEF\",\"C7orf14\",\"CAIN\",\"CAN\",\"CBP20\",\"CBP80\",\"CG1\",\"CPSF1\",\"CPSF100\",\"CPSF160\",\"CPSF2\",\"CPSF3\",\"CPSF30\",\"CPSF4\",\"CPSF73\",\"D3S1231E\",\"EIF4E\",\"EIF4EL1\",\"EIF4F\",\"FIP1\",\"FIP1L1\",\"KIAA0023\",\"KIAA0095\",\"KIAA0169\",\"KIAA0197\",\"KIAA0225\",\"KIAA0618\",\"KIAA0791\",\"KIAA0906\",\"KIAA1367\",\"MP44\",\"MRNP41\",\"NAR\",\"NCBP\",\"NCBP1\",\"NCBP2\",\"NDC1\",\"NEB1\",\"NPAP60L\",\"NUP107\",\"NUP120\",\"NUP121\",\"NUP133\",\"NUP153\",\"NUP155\",\"NUP160\",\"NUP188\",\"NUP205\",\"NUP210\",\"NUP214\",\"NUP35\",\"NUP358\",\"NUP37\",\"NUP42\",\"NUP43\",\"NUP50\",\"NUP53\",\"NUP54\",\"NUP62\",\"NUP75\",\"NUP85\",\"NUP88\",\"NUP93\",\"NUPL2\",\"NXF1\",\"PCNT1\",\"POM121\",\"POM121A\",\"POM121C\",\"RAE1\",\"RANBP2\",\"RHE\",\"SEC13\",\"SEC13A\",\"SEC13L1\",\"SEC13R\",\"SPK\",\"SYMPK\",\"TAP\",\"THOC4\",\"TMEM48\",\"TPR\",\"WDC146\",\"WDR33\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "BDNF activates NTRK2 (TRKB) signaling", "protein_name": "[{\"label\":\"BDNF/NT-3 growth factors receptor\",\"id\":\"Q16620\"},{\"label\":\"Brain-derived neurotrophic factor\",\"id\":\"P23560\"}]", "uniprot_id": "[\"P23560\",\"Q16620\"]", "gene_symbol": "[\"BDNF\",\"NTRK2\",\"TRKB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation by c-FLIP", "protein_name": "[{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"FAS-associated death domain protein\",\"id\":\"Q13158\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 10\",\"id\":\"P50591\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 6\",\"id\":\"P48023\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10A\",\"id\":\"O00220\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10B\",\"id\":\"O14763\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 6\",\"id\":\"P25445\"},{\"label\":\"Tumor necrosis factor receptor type 1-associated DEATH domain protein\",\"id\":\"Q15628\"}]", "uniprot_id": "[\"O00220\",\"O14763\",\"P25445\",\"P48023\",\"P50591\",\"Q12933\",\"Q13158\",\"Q13546\",\"Q14790\",\"Q15628\"]", "gene_symbol": "[\"APO2\",\"APO2L\",\"APT1\",\"APT1LG1\",\"CASP8\",\"CD95L\",\"DR4\",\"DR5\",\"FADD\",\"FAS\",\"FAS1\",\"FASL\",\"FASLG\",\"KILLER\",\"MCH5\",\"MORT1\",\"RIP\",\"RIP1\",\"RIPK1\",\"TNFRSF10A\",\"TNFRSF10B\",\"TNFRSF6\",\"TNFSF10\",\"TNFSF6\",\"TRADD\",\"TRAF2\",\"TRAIL\",\"TRAILR1\",\"TRAILR2\",\"TRAP3\",\"TRICK2\",\"ZTNFR9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SARS-CoV-2 targets PDZ proteins in cell-cell junction", "protein_name": "[{\"label\":\"Envelope small membrane protein\",\"id\":\"P0DTC4\"},{\"label\":\"Gap junction alpha-1 protein\",\"id\":\"P17302\"},{\"label\":\"InaD-like protein\",\"id\":\"Q8NI35\"},{\"label\":\"Protein PALS1\",\"id\":\"Q8N3R9\"},{\"label\":\"Protein crumbs homolog 3\",\"id\":\"Q9BUF7\"},{\"label\":\"Tight junction protein ZO-1\",\"id\":\"Q07157\"}]", "uniprot_id": "[\"P0DTC4\",\"P17302\",\"Q07157\",\"Q8N3R9\",\"Q8NI35\",\"Q9BUF7\"]", "gene_symbol": "[\"CIPP\",\"CRB3\",\"E\",\"GJA1\",\"GJAL\",\"INADL\",\"MPP5\",\"PALS1\",\"PATJ\",\"TJP1\",\"ZO1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G beta:gamma signalling through BTK", "protein_name": "[{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Tyrosine-protein kinase BTK\",\"id\":\"Q06187\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O60262\",\"P16520\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63211\",\"P63215\",\"P63218\",\"Q06187\",\"Q9HAV0\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": "[\"AGMX1\",\"ATK\",\"BPK\",\"BTK\",\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNB5\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT1\",\"GNGT10\",\"GNGT11\",\"GNGT2\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT8\",\"GNGT9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TICAM1,TRAF6-dependent induction of TAK1 complex", "protein_name": "[{\"label\":\"Mitogen-activated protein kinase kinase kinase 7\",\"id\":\"O43318\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 1\",\"id\":\"Q15750\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2\",\"id\":\"Q9NYJ8\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 3\",\"id\":\"Q8N5C8\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O15455\",\"O43318\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q15750\",\"Q8IUC6\",\"Q8N5C8\",\"Q9NYJ8\",\"Q9Y4K3\"]", "gene_symbol": "[\"KIAA0733\",\"MAP3K7\",\"MAP3K7IP1\",\"MAP3K7IP2\",\"MAP3K7IP3\",\"PRVTIRB\",\"RNF85\",\"RPS27A\",\"TAB1\",\"TAB2\",\"TAB3\",\"TAK1\",\"TICAM1\",\"TLR3\",\"TRAF6\",\"TRIF\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2\",\"id\":\"P16885\"},{\"label\":\"B-cell antigen receptor complex-associated protein alpha chain\",\"id\":\"P11912\"},{\"label\":\"B-cell antigen receptor complex-associated protein beta chain\",\"id\":\"P40259\"},{\"label\":\"B-cell linker protein\",\"id\":\"Q8WV28\"},{\"label\":\"B-cell receptor CD22\",\"id\":\"P20273\"},{\"label\":\"B-lymphocyte antigen CD19\",\"id\":\"P15391\"},{\"label\":\"Calcium release-activated calcium channel protein 1\",\"id\":\"Q96D31\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide\",\"id\":\"Q9UN19\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant delta\",\"id\":\"P01880\"},{\"label\":\"Immunoglobulin heavy constant mu\",\"id\":\"P01871\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 3-20\",\"id\":\"P01619\"},{\"label\":\"Immunoglobulin kappa variable 3D-20\",\"id\":\"A0A0C4DH25\"},{\"label\":\"Immunoglobulin kappa variable 4-1\",\"id\":\"P06312\"},{\"label\":\"Immunoglobulin kappa variable 5-2\",\"id\":\"P06315\"},{\"label\":\"Immunoglobulin lambda constant 1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 3\",\"id\":\"P0DOY3\"},{\"label\":\"Immunoglobulin lambda constant 6\",\"id\":\"P0CF74\"},{\"label\":\"Immunoglobulin lambda constant 7\",\"id\":\"A0M8Q6\"},{\"label\":\"Immunoglobulin lambda variable 1-40\",\"id\":\"P01703\"},{\"label\":\"Immunoglobulin lambda variable 1-44\",\"id\":\"P01699\"},{\"label\":\"Immunoglobulin lambda variable 1-47\",\"id\":\"P01700\"},{\"label\":\"Immunoglobulin lambda variable 1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 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alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform\",\"id\":\"O00329\"},{\"label\":\"Phosphoinositide 3-kinase adapter protein 1\",\"id\":\"Q6ZUJ8\"},{\"label\":\"Protein orai-2\",\"id\":\"Q96SN7\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"S-adenosylhomocysteine hydrolase-like protein 1\",\"id\":\"O43865\"},{\"label\":\"SH2/SH3 adapter protein NCK1\",\"id\":\"P16333\"},{\"label\":\"SH3 domain-containing kinase-binding protein 1\",\"id\":\"Q96B97\"},{\"label\":\"Short transient receptor potential channel 1\",\"id\":\"P48995\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Stromal interaction molecule 1\",\"id\":\"Q13586\"},{\"label\":\"Tyrosine-protein kinase BTK\",\"id\":\"Q06187\"},{\"label\":\"Tyrosine-protein kinase Blk\",\"id\":\"P51451\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase SYK\",\"id\":\"P43405\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"},{\"label\":\"UGa8H (Fragment)\",\"id\":\"A2KUC3\"}]", "uniprot_id": 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"gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Beta oxidation of myristoyl-CoA to lauroyl-CoA", "protein_name": "[{\"label\":\"Long-chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P28330\"},{\"label\":\"Trifunctional enzyme subunit alpha, mitochondrial\",\"id\":\"P40939\"},{\"label\":\"Trifunctional enzyme subunit beta, mitochondrial\",\"id\":\"P55084\"}]", "uniprot_id": "[\"P28330\",\"P40939\",\"P55084\"]", "gene_symbol": "[\"ACADL\",\"HADH\",\"HADHA\",\"HADHB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Trafficking of GluR2-containing AMPA receptors", "protein_name": "[{\"label\":\"AP-2 complex subunit alpha-1\",\"id\":\"O95782\"},{\"label\":\"Glutamate receptor 1\",\"id\":\"P42261\"},{\"label\":\"Glutamate receptor 2\",\"id\":\"P42262\"},{\"label\":\"Glutamate receptor 3\",\"id\":\"P42263\"},{\"label\":\"Glutamate receptor 4\",\"id\":\"P48058\"},{\"label\":\"Glutamate receptor-interacting protein 1\",\"id\":\"Q9Y3R0\"},{\"label\":\"Glutamate receptor-interacting protein 2\",\"id\":\"Q9C0E4\"},{\"label\":\"PRKCA-binding protein\",\"id\":\"Q9NRD5\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Protein kinase C beta type\",\"id\":\"P05771\"},{\"label\":\"Protein kinase C gamma type\",\"id\":\"P05129\"},{\"label\":\"Tetraspanin-7\",\"id\":\"P41732\"},{\"label\":\"Vesicle-fusing ATPase\",\"id\":\"P46459\"}]", "uniprot_id": "[\"O95782\",\"P05129\",\"P05771\",\"P17252\",\"P41732\",\"P42261\",\"P42262\",\"P42263\",\"P46459\",\"P48058\",\"Q9C0E4\",\"Q9NRD5\",\"Q9Y3R0\"]", "gene_symbol": "[\"A15\",\"ADTAA\",\"AP2A1\",\"CLAPA1\",\"DXS1692E\",\"GLUA1\",\"GLUH1\",\"GLUR1\",\"GLUR2\",\"GLUR3\",\"GLUR4\",\"GLURC\",\"GRIA1\",\"GRIA2\",\"GRIA3\",\"GRIA4\",\"GRIP1\",\"GRIP2\",\"GluA2\",\"GluA3\",\"GluA4\",\"KIAA1719\",\"MXS1\",\"NSF\",\"PICK1\",\"PKCA\",\"PKCB\",\"PKCG\",\"PRKACA\",\"PRKCA\",\"PRKCABP\",\"PRKCB\",\"PRKCB1\",\"PRKCG\",\"TM4SF2\",\"TSPAN7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Tryptophan catabolism", "protein_name": "[{\"label\":\"2-amino-3-carboxymuconate-6-semialdehyde decarboxylase\",\"id\":\"Q8TDX5\"},{\"label\":\"3-hydroxyanthranilate 3,4-dioxygenase\",\"id\":\"P46952\"},{\"label\":\"Amino acid transporter heavy chain SLC3A2\",\"id\":\"P08195\"},{\"label\":\"Indoleamine 2,3-dioxygenase 1\",\"id\":\"P14902\"},{\"label\":\"Indoleamine 2,3-dioxygenase 2\",\"id\":\"Q6ZQW0\"},{\"label\":\"Kynureninase\",\"id\":\"Q16719\"},{\"label\":\"Kynurenine 3-monooxygenase\",\"id\":\"O15229\"},{\"label\":\"Kynurenine formamidase\",\"id\":\"Q63HM1\"},{\"label\":\"Kynurenine--oxoglutarate transaminase 1\",\"id\":\"Q16773\"},{\"label\":\"Kynurenine--oxoglutarate transaminase 3\",\"id\":\"Q6YP21\"},{\"label\":\"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial\",\"id\":\"Q8N5Z0\"},{\"label\":\"Large neutral amino acids transporter small subunit 1\",\"id\":\"Q01650\"},{\"label\":\"Neutral amino acid uniporter 4\",\"id\":\"Q6YBV0\"},{\"label\":\"Tryptophan 2,3-dioxygenase\",\"id\":\"P48775\"}]", "uniprot_id": "[\"O15229\",\"P08195\",\"P14902\",\"P46952\",\"P48775\",\"Q01650\",\"Q16719\",\"Q16773\",\"Q63HM1\",\"Q6YBV0\",\"Q6YP21\",\"Q6ZQW0\",\"Q8N5Z0\",\"Q8TDX5\"]", "gene_symbol": "[\"AADAT\",\"ACMSD\",\"AFMID\",\"CCBL1\",\"CCBL2\",\"CD98LC\",\"HAAO\",\"IDO\",\"IDO1\",\"IDO2\",\"INDO\",\"INDOL1\",\"KAT2\",\"KAT3\",\"KMO\",\"KYAT1\",\"KYAT2\",\"KYAT3\",\"KYNU\",\"LAT1\",\"MDU1\",\"MPE16\",\"PAT4\",\"SLC36A4\",\"SLC3A2\",\"SLC7A5\",\"TDO\",\"TDO2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "GLI3 is processed to GLI3R by the proteasome", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Casein kinase I isoform 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1\",\"id\":\"Q8IZL8\"},{\"label\":\"Protein-tyrosine kinase 6\",\"id\":\"Q13882\"}]", "uniprot_id": "[\"P04150\",\"Q13882\",\"Q16665\",\"Q8IZL8\",\"Q99814\"]", "gene_symbol": "[\"BHLHE73\",\"BHLHE78\",\"BRK\",\"EPAS1\",\"GRL\",\"HIF1A\",\"HIF2A\",\"HMX3\",\"MNAR\",\"MOP1\",\"MOP2\",\"NR3C1\",\"PASD2\",\"PASD8\",\"PELP1\",\"PTK6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Thyroxine biosynthesis", "protein_name": "[{\"label\":\"Dual oxidase 1\",\"id\":\"Q9NRD9\"},{\"label\":\"Dual oxidase 2\",\"id\":\"Q9NRD8\"},{\"label\":\"Glycoprotein hormones alpha chain\",\"id\":\"P01215\"},{\"label\":\"Iodotyrosine deiodinase 1\",\"id\":\"Q6PHW0\"},{\"label\":\"Sodium/iodide cotransporter\",\"id\":\"Q92911\"},{\"label\":\"Thyroid peroxidase\",\"id\":\"P07202\"},{\"label\":\"Thyrotropin subunit beta\",\"id\":\"P01222\"}]", "uniprot_id": "[\"P01215\",\"P01222\",\"P07202\",\"Q6PHW0\",\"Q92911\",\"Q9NRD8\",\"Q9NRD9\"]", "gene_symbol": 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3\",\"id\":\"A6NHL2\"},{\"label\":\"Tubulin alpha-1A chain\",\"id\":\"Q71U36\"},{\"label\":\"Tubulin alpha-1B chain\",\"id\":\"P68363\"},{\"label\":\"Tubulin alpha-1C chain\",\"id\":\"Q9BQE3\"},{\"label\":\"Tubulin alpha-3C chain\",\"id\":\"P0DPH7\"},{\"label\":\"Tubulin alpha-3D chain\",\"id\":\"P0DPH8\"},{\"label\":\"Tubulin alpha-3E chain\",\"id\":\"Q6PEY2\"},{\"label\":\"Tubulin alpha-4A chain\",\"id\":\"P68366\"},{\"label\":\"Tubulin alpha-8 chain\",\"id\":\"Q9NY65\"},{\"label\":\"Tubulin beta-1 chain\",\"id\":\"Q9H4B7\"},{\"label\":\"Tubulin beta-2A chain\",\"id\":\"Q13885\"},{\"label\":\"Tubulin beta-2B chain\",\"id\":\"Q9BVA1\"},{\"label\":\"Tubulin beta-3 chain\",\"id\":\"Q13509\"},{\"label\":\"Tubulin beta-4A chain\",\"id\":\"P04350\"},{\"label\":\"Tubulin beta-4B chain\",\"id\":\"P68371\"},{\"label\":\"Tubulin beta-6 chain\",\"id\":\"Q9BUF5\"}]", "uniprot_id": 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4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 22\",\"id\":\"Q9HCT0\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 3\",\"id\":\"P11487\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"}]", "uniprot_id": "[\"O15520\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11487\",\"P19174\",\"P31371\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", "gene_symbol": 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1\",\"id\":\"Q9GZV3\"},{\"label\":\"Multidrug and toxin extrusion protein 1\",\"id\":\"Q96FL8\"},{\"label\":\"Multidrug and toxin extrusion protein 2\",\"id\":\"Q86VL8\"},{\"label\":\"Sodium-dependent organic anion transporter\",\"id\":\"Q3KNW5\"},{\"label\":\"Urea transporter 1\",\"id\":\"Q13336\"},{\"label\":\"Urea transporter 2\",\"id\":\"Q15849\"}]", "uniprot_id": "[\"Q13336\",\"Q15849\",\"Q3KNW5\",\"Q53GD3\",\"Q86VL8\",\"Q8IWA5\",\"Q8N4M1\",\"Q8NCS7\",\"Q8WWI5\",\"Q96FL8\",\"Q9GZV3\"]", "gene_symbol": "[\"C6orf29\",\"CD92\",\"CDW92\",\"CHT1\",\"CTL1\",\"CTL2\",\"CTL3\",\"CTL4\",\"CTL5\",\"HUT11\",\"HUT2\",\"JK\",\"MATE1\",\"MATE2\",\"NG22\",\"RACH1\",\"SLC10A6\",\"SLC14A1\",\"SLC14A2\",\"SLC44A1\",\"SLC44A2\",\"SLC44A3\",\"SLC44A4\",\"SLC44A5\",\"SLC47A1\",\"SLC47A2\",\"SLC5A7\",\"SOAT\",\"TPPT1\",\"UT1\",\"UT2\",\"UTE\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CRMPs in Sema3A signaling", "protein_name": "[{\"label\":\"Cyclin-dependent kinase 5 activator 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"gene_symbol": "[\"C6orf68\",\"DHDDS\",\"HDS\",\"NGBR\",\"NUS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Specification of the neural plate border", "protein_name": "[{\"label\":\"Bone morphogenetic protein 4\",\"id\":\"P12644\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Homeobox protein DLX-5\",\"id\":\"P56178\"},{\"label\":\"Homeobox protein GBX-2\",\"id\":\"P52951\"},{\"label\":\"Homeobox protein MSX-1\",\"id\":\"P28360\"},{\"label\":\"POU domain, class 5, transcription factor 1\",\"id\":\"Q01860\"},{\"label\":\"Paired box protein Pax-3\",\"id\":\"P23760\"},{\"label\":\"Paired box protein Pax-7\",\"id\":\"P23759\"},{\"label\":\"Protein Wnt-3a\",\"id\":\"P56704\"},{\"label\":\"Transcription factor 7-like 1\",\"id\":\"Q9HCS4\"},{\"label\":\"Transcription factor AP-2 gamma\",\"id\":\"Q92754\"},{\"label\":\"Transcription factor AP-2-alpha\",\"id\":\"P05549\"},{\"label\":\"Transcription factor AP-2-beta\",\"id\":\"Q92481\"},{\"label\":\"Transcription factor SOX-2\",\"id\":\"P48431\"},{\"label\":\"Transcriptional activator Myb\",\"id\":\"P10242\"},{\"label\":\"Zinc finger protein ZIC 1\",\"id\":\"Q15915\"}]", "uniprot_id": "[\"P05549\",\"P08620\",\"P10242\",\"P12644\",\"P23759\",\"P23760\",\"P28360\",\"P35222\",\"P48431\",\"P52951\",\"P56178\",\"P56704\",\"Q01860\",\"Q15915\",\"Q92481\",\"Q92754\",\"Q9HCS4\"]", "gene_symbol": "[\"AP2TF\",\"BMP2B\",\"BMP4\",\"CTNNB\",\"CTNNB1\",\"DLX5\",\"DVR4\",\"FGF4\",\"GBX2\",\"HOX7\",\"HST\",\"HSTF1\",\"HUP1\",\"HUP2\",\"KS3\",\"MSX1\",\"MYB\",\"OCT3\",\"OCT4\",\"OTF3\",\"PAX3\",\"PAX7\",\"POU5F1\",\"SOX2\",\"TCF3\",\"TCF7L1\",\"TFAP2\",\"TFAP2A\",\"TFAP2B\",\"TFAP2C\",\"WNT3A\",\"ZIC\",\"ZIC1\",\"ZNF201\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Resistance of ERBB2 KD mutants to AEE788", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P04626\",\"P07900\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Pyroptosis", "protein_name": "[{\"label\":\"Apoptosis regulator BAX\",\"id\":\"Q07812\"},{\"label\":\"Bcl-2 homologous antagonist/killer\",\"id\":\"Q16611\"},{\"label\":\"Caspase-1\",\"id\":\"P29466\"},{\"label\":\"Caspase-3\",\"id\":\"P42574\"},{\"label\":\"Caspase-4\",\"id\":\"P49662\"},{\"label\":\"Caspase-5\",\"id\":\"P51878\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Charged multivesicular body protein 2a\",\"id\":\"O43633\"},{\"label\":\"Charged multivesicular body protein 2b\",\"id\":\"Q9UQN3\"},{\"label\":\"Charged multivesicular body protein 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protein 63\",\"id\":\"Q9H3D4\"}]", "uniprot_id": "[\"O43633\",\"O60443\",\"P01583\",\"P01584\",\"P04637\",\"P08246\",\"P09429\",\"P10144\",\"P10914\",\"P14316\",\"P29466\",\"P42574\",\"P49662\",\"P51878\",\"P57764\",\"P99999\",\"Q07812\",\"Q14116\",\"Q16611\",\"Q8WUX9\",\"Q96CF2\",\"Q96FZ7\",\"Q9BY43\",\"Q9H3D4\",\"Q9H444\",\"Q9UQN3\",\"Q9Y3E7\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Peroxisomal lipid metabolism", "protein_name": "[{\"label\":\"2-Hydroxyacid oxidase 2\",\"id\":\"Q9NYQ3\"},{\"label\":\"Acyl-CoA-binding domain-containing protein 4\",\"id\":\"Q8NC06\"},{\"label\":\"Acyl-CoA-binding domain-containing protein 5\",\"id\":\"Q5T8D3\"},{\"label\":\"Acyl-coenzyme A diphosphatase NUDT19\",\"id\":\"A8MXV4\"},{\"label\":\"Peroxisomal coenzyme A diphosphatase NUDT7\",\"id\":\"P0C024\"}]", "uniprot_id": "[\"A8MXV4\",\"P0C024\",\"Q5T8D3\",\"Q8NC06\",\"Q9NYQ3\"]", "gene_symbol": "[\"ACBD4\",\"ACBD5\",\"HAO2\",\"HAOX2\",\"KIAA1996\",\"NUDT19\",\"NUDT7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TYSND1 cleaves peroxisomal proteins", "protein_name": "[{\"label\":\"3-ketoacyl-CoA thiolase, peroxisomal\",\"id\":\"P09110\"},{\"label\":\"Alkyldihydroxyacetonephosphate synthase, peroxisomal\",\"id\":\"O00116\"},{\"label\":\"Peroxisomal acyl-coenzyme A oxidase 1\",\"id\":\"Q15067\"},{\"label\":\"Peroxisomal leader peptide-processing protease\",\"id\":\"Q2T9J0\"},{\"label\":\"Peroxisomal multifunctional enzyme type 2\",\"id\":\"P51659\"},{\"label\":\"Phytanoyl-CoA dioxygenase, peroxisomal\",\"id\":\"O14832\"},{\"label\":\"Sterol carrier protein 2\",\"id\":\"P22307\"}]", "uniprot_id": "[\"O00116\",\"O14832\",\"P09110\",\"P22307\",\"P51659\",\"Q15067\",\"Q2T9J0\"]", "gene_symbol": "[\"ACAA\",\"ACAA1\",\"ACOX\",\"ACOX1\",\"AGPS\",\"EDH17B4\",\"HSD17B4\",\"PAHX\",\"PHYH\",\"PTHIO\",\"SCP2\",\"SDR8C1\",\"TYSND1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Glycerophospholipid catabolism", "protein_name": "[{\"label\":\"Glycerophosphocholine cholinephosphodiesterase ENPP6\",\"id\":\"Q6UWR7\"},{\"label\":\"Glycerophosphodiester phosphodiesterase 1\",\"id\":\"Q9NZC3\"},{\"label\":\"Glycerophosphodiester phosphodiesterase domain-containing protein 5\",\"id\":\"Q8WTR4\"},{\"label\":\"Lysophospholipase D GDPD1\",\"id\":\"Q8N9F7\"},{\"label\":\"Lysophospholipase D GDPD3\",\"id\":\"Q7L5L3\"},{\"label\":\"Patatin-like phospholipase domain-containing protein 6\",\"id\":\"Q8IY17\"},{\"label\":\"Patatin-like phospholipase domain-containing protein 7\",\"id\":\"Q6ZV29\"}]", "uniprot_id": "[\"Q6UWR7\",\"Q6ZV29\",\"Q7L5L3\",\"Q8IY17\",\"Q8N9F7\",\"Q8WTR4\",\"Q9NZC3\"]", "gene_symbol": "[\"C9orf111\",\"ENPP6\",\"GDE1\",\"GDE2\",\"GDE4\",\"GDE7\",\"GDPD1\",\"GDPD3\",\"GDPD5\",\"MIR16\",\"NTE\",\"PNPLA6\",\"PNPLA7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Calcineurin activates NFAT", "protein_name": "[{\"label\":\"Calcineurin subunit B type 1\",\"id\":\"P63098\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Nuclear factor of activated T-cells, cytoplasmic 1\",\"id\":\"O95644\"},{\"label\":\"Nuclear factor of activated T-cells, cytoplasmic 2\",\"id\":\"Q13469\"},{\"label\":\"Nuclear factor of activated T-cells, cytoplasmic 3\",\"id\":\"Q12968\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase FKBP1A\",\"id\":\"P62942\"},{\"label\":\"Protein phosphatase 3 catalytic subunit alpha\",\"id\":\"Q08209\"},{\"label\":\"Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform\",\"id\":\"P16298\"}]", "uniprot_id": "[\"O95644\",\"P0DP23\",\"P16298\",\"P62937\",\"P62942\",\"P63098\",\"Q08209\",\"Q12968\",\"Q13469\"]", "gene_symbol": "[\"CALM\",\"CALM1\",\"CALNA\",\"CALNA2\",\"CALNB\",\"CAM\",\"CAM1\",\"CNA\",\"CNA2\",\"CNB\",\"CYPA\",\"FKBP1\",\"FKBP12\",\"FKBP1A\",\"NFAT1\",\"NFAT2\",\"NFAT4\",\"NFATC\",\"NFATC1\",\"NFATC2\",\"NFATC3\",\"NFATP\",\"PPIA\",\"PPP3CA\",\"PPP3CB\",\"PPP3R1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Loss of MECP2 binding ability to 5mC-DNA", "protein_name": "[{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Paired amphipathic helix protein Sin3a\",\"id\":\"Q96ST3\"}]", "uniprot_id": "[\"Q13547\",\"Q96ST3\"]", "gene_symbol": "[\"HDAC1\",\"RPD3L1\",\"SIN3A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Negative feedback regulation of MAPK pathway", "protein_name": "[{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 1\",\"id\":\"Q02750\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 2\",\"id\":\"P36507\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"}]", "uniprot_id": "[\"P04049\",\"P15056\",\"P27361\",\"P28482\",\"P36507\",\"Q02750\"]", "gene_symbol": "[\"BRAF\",\"BRAF1\",\"ERK1\",\"ERK2\",\"MAP2K1\",\"MAP2K2\",\"MAPK1\",\"MAPK3\",\"MEK1\",\"MEK2\",\"MKK2\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"PRKMK1\",\"PRKMK2\",\"RAF\",\"RAF1\",\"RAFB1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Stimuli-sensing channels", "protein_name": "[{\"label\":\"Acid-sensing ion channel 1\",\"id\":\"P78348\"},{\"label\":\"Acid-sensing ion channel 2\",\"id\":\"Q16515\"},{\"label\":\"Acid-sensing ion channel 3\",\"id\":\"Q9UHC3\"},{\"label\":\"Acid-sensing ion channel 4\",\"id\":\"Q96FT7\"},{\"label\":\"Acid-sensing ion channel 5\",\"id\":\"Q9NY37\"},{\"label\":\"Amiloride-sensitive sodium channel subunit alpha\",\"id\":\"P37088\"},{\"label\":\"Amiloride-sensitive sodium channel subunit beta\",\"id\":\"P51168\"},{\"label\":\"Amiloride-sensitive sodium channel subunit delta\",\"id\":\"P51172\"},{\"label\":\"Amiloride-sensitive sodium channel subunit 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"gtc_id": "[\"\"]" }, { "pathway_label": "Interactions of Tat with host cellular proteins", "protein_name": "[{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"Protein Tat\",\"id\":\"P04608\"}]", "uniprot_id": "[\"O60563\",\"P04608\",\"P50750\"]", "gene_symbol": "[\"CCNT1\",\"CDC2L4\",\"CDK9\",\"TAK\",\"tat\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of Ca-permeable Kainate Receptor", "protein_name": "[{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Disks large homolog 1\",\"id\":\"Q12959\"},{\"label\":\"Disks large homolog 3\",\"id\":\"Q92796\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Glutamate receptor ionotropic, kainate 1\",\"id\":\"P39086\"},{\"label\":\"Glutamate receptor ionotropic, kainate 2\",\"id\":\"Q13002\"},{\"label\":\"Glutamate receptor ionotropic, kainate 3\",\"id\":\"Q13003\"},{\"label\":\"Glutamate receptor ionotropic, kainate 4\",\"id\":\"Q16099\"},{\"label\":\"Glutamate receptor ionotropic, kainate 5\",\"id\":\"Q16478\"},{\"label\":\"Neurocalcin-delta\",\"id\":\"P61601\"}]", "uniprot_id": "[\"P0DP23\",\"P39086\",\"P61601\",\"P78352\",\"Q12959\",\"Q13002\",\"Q13003\",\"Q16099\",\"Q16478\",\"Q92796\"]", "gene_symbol": "[\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"DLG1\",\"DLG3\",\"DLG4\",\"GLUR5\",\"GLUR6\",\"GLUR7\",\"GRIK\",\"GRIK1\",\"GRIK2\",\"GRIK3\",\"GRIK4\",\"GRIK5\",\"KIAA1232\",\"NCALD\",\"PSD95\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective HK1 causes hexokinase deficiency (HK deficiency)", "protein_name": "[{\"label\":\"Hexokinase-1\",\"id\":\"P19367\"}]", "uniprot_id": "[\"P19367\"]", "gene_symbol": "[\"HK1\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)", "protein_name": "[{\"label\":\"Excitatory amino acid transporter 3\",\"id\":\"P43005\"}]", "uniprot_id": "[\"P43005\"]", "gene_symbol": "[\"EAAC1\",\"EAAT3\",\"HEAAC1\",\"SLC1A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX1 regulates transcription of genes involved in WNT signaling", "protein_name": "[{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"Estrogen receptor\",\"id\":\"P03372\"},{\"label\":\"Forkhead box protein P3\",\"id\":\"Q9BZS1\"},{\"label\":\"R-spondin-3\",\"id\":\"Q9BXY4\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"}]", "uniprot_id": "[\"O15169\",\"P03372\",\"Q01196\",\"Q13951\",\"Q9BXY4\",\"Q9BZS1\"]", "gene_symbol": "[\"AML1\",\"AXIN\",\"AXIN1\",\"CBFA2\",\"CBFB\",\"ESR\",\"ESR1\",\"FOXP3\",\"IPEX\",\"NR3A1\",\"PWTSR\",\"RSPO3\",\"RUNX1\",\"THSD2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of Dolichyl-phosphate", "protein_name": "[{\"label\":\"Dehydrodolichyl diphosphate synthase complex subunit DHDDS\",\"id\":\"Q86SQ9\"},{\"label\":\"Dehydrodolichyl diphosphate synthase complex subunit NUS1\",\"id\":\"Q96E22\"},{\"label\":\"Diphosphomevalonate decarboxylase\",\"id\":\"P53602\"},{\"label\":\"Dolichol kinase\",\"id\":\"Q9UPQ8\"},{\"label\":\"Dolichyldiphosphatase 1\",\"id\":\"Q86YN1\"},{\"label\":\"Polyprenal reductase\",\"id\":\"Q9H8P0\"}]", "uniprot_id": "[\"P53602\",\"Q86SQ9\",\"Q86YN1\",\"Q96E22\",\"Q9H8P0\",\"Q9UPQ8\"]", "gene_symbol": "[\"C6orf68\",\"DHDDS\",\"DOLK\",\"DOLPP1\",\"HDS\",\"KIAA1094\",\"LSFR2\",\"MPD\",\"MVD\",\"NGBR\",\"NUS1\",\"SRD5A2L\",\"SRD5A3\",\"TMEM15\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Stimulation of the cell death response by PAK-2p34", "protein_name": "[{\"label\":\"Caspase-3\",\"id\":\"P42574\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"}]", "uniprot_id": "[\"P42574\",\"Q13177\"]", "gene_symbol": "[\"CASP3\",\"CPP32\",\"PAK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Enhanced binding of GP1BA variant to VWF multimer:collagen", "protein_name": "[{\"label\":\"Platelet glycoprotein IX\",\"id\":\"P14770\"},{\"label\":\"Platelet glycoprotein Ib alpha chain\",\"id\":\"P07359\"},{\"label\":\"Platelet glycoprotein Ib beta chain\",\"id\":\"P13224\"},{\"label\":\"Platelet glycoprotein V\",\"id\":\"P40197\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"P04275\",\"P07359\",\"P13224\",\"P14770\",\"P40197\"]", "gene_symbol": "[\"F8VWF\",\"GP1BA\",\"GP1BB\",\"GP5\",\"GP9\",\"VWF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TLR3 deficiency - HSE", "protein_name": "[{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"}]", "uniprot_id": "[\"O15455\"]", "gene_symbol": "[\"TLR3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by Insulin receptor", "protein_name": "[{\"label\":\"Insulin receptor\",\"id\":\"P06213\"},{\"label\":\"Insulin\",\"id\":\"P01308\"}]", "uniprot_id": "[\"P01308\",\"P06213\"]", "gene_symbol": "[\"INS\",\"INSR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Estrogen-stimulated signaling through PRKCZ", "protein_name": "[{\"label\":\"3-phosphoinositide-dependent protein kinase 1\",\"id\":\"O15530\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Protein kinase C zeta type\",\"id\":\"Q05513\"}]", "uniprot_id": "[\"O15530\",\"P01111\",\"P01112\",\"P28482\",\"Q05513\"]", "gene_symbol": "[\"ERK2\",\"HRAS\",\"HRAS1\",\"MAPK1\",\"NRAS\",\"PDK1\",\"PDPK1\",\"PKC2\",\"PRKCZ\",\"PRKM1\",\"PRKM2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by NODAL", "protein_name": "[{\"label\":\"Activin receptor type-1B\",\"id\":\"P36896\"},{\"label\":\"Activin receptor type-1C\",\"id\":\"Q8NER5\"},{\"label\":\"Activin receptor type-2A\",\"id\":\"P27037\"},{\"label\":\"Activin receptor type-2B\",\"id\":\"Q13705\"},{\"label\":\"Cerberus\",\"id\":\"O95813\"},{\"label\":\"Cryptic protein\",\"id\":\"P0CG37\"},{\"label\":\"DAN domain family member 5\",\"id\":\"Q8N907\"},{\"label\":\"Dr1-associated corepressor\",\"id\":\"Q14919\"},{\"label\":\"Embryonic growth/differentiation factor 1\",\"id\":\"P27539\"},{\"label\":\"Forkhead box protein H1\",\"id\":\"O75593\"},{\"label\":\"Forkhead box protein O3\",\"id\":\"O43524\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Left-right determination factor 1\",\"id\":\"O75610\"},{\"label\":\"Left-right determination factor 2\",\"id\":\"O00292\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Mothers against decapentaplegic homolog 2\",\"id\":\"Q15796\"},{\"label\":\"Mothers against decapentaplegic homolog 3\",\"id\":\"P84022\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"Nodal homolog\",\"id\":\"Q96S42\"},{\"label\":\"Proprotein convertase subtilisin/kexin type 6\",\"id\":\"P29122\"},{\"label\":\"Protein Cripto\",\"id\":\"P13385\"},{\"label\":\"Putative protein CRIPTO3\",\"id\":\"P51864\"}]", "uniprot_id": "[\"O00292\",\"O43524\",\"O75593\",\"O75610\",\"O95813\",\"P09958\",\"P0CG37\",\"P13385\",\"P27037\",\"P27361\",\"P27539\",\"P28482\",\"P29122\",\"P36896\",\"P51864\",\"P84022\",\"Q13485\",\"Q13705\",\"Q14919\",\"Q15796\",\"Q8N907\",\"Q8NER5\",\"Q96S42\"]", "gene_symbol": "[\"ACVR1B\",\"ACVR1C\",\"ACVR2\",\"ACVR2A\",\"ACVR2B\",\"ACVRLK4\",\"ALK4\",\"ALK7\",\"CER1\",\"CER2\",\"CFC1\",\"CKTSF1B3\",\"CRIPTO\",\"CRIPTO-1\",\"CRIPTO-3\",\"CRIPTO3\",\"DAND4\",\"DAND5\",\"DPC4\",\"DRAP1\",\"EBAF\",\"ERK1\",\"ERK2\",\"FAST1\",\"FAST2\",\"FKHRL1\",\"FOXH1\",\"FOXO3\",\"FOXO3A\",\"FUR\",\"FURIN\",\"GDF1\",\"GREM3\",\"LEFTA\",\"LEFTB\",\"LEFTY1\",\"LEFTY2\",\"LEFTYA\",\"LEFTYB\",\"MADH2\",\"MADH3\",\"MADH4\",\"MADR2\",\"MAPK1\",\"MAPK3\",\"NODAL\",\"PACE\",\"PACE4\",\"PCSK3\",\"PCSK6\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"SMAD2\",\"SMAD3\",\"SMAD4\",\"SP1\",\"TDGF1\",\"TDGF1P3\",\"TDGF2\",\"TDGF3\",\"TGFB4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of HSF1-mediated heat shock response", "protein_name": "[{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"Active regulator of SIRT1\",\"id\":\"Q86WX3\"},{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"BAG family molecular chaperone regulator 1\",\"id\":\"Q99933\"},{\"label\":\"BAG family molecular chaperone regulator 2\",\"id\":\"O95816\"},{\"label\":\"BAG family molecular chaperone regulator 3\",\"id\":\"O95817\"},{\"label\":\"BAG family molecular chaperone regulator 4\",\"id\":\"O95429\"},{\"label\":\"BAG family molecular chaperone regulator 5\",\"id\":\"Q9UL15\"},{\"label\":\"Cell cycle and apoptosis regulator protein 2\",\"id\":\"Q8N163\"},{\"label\":\"DnaJ homolog subfamily B member 1\",\"id\":\"P25685\"},{\"label\":\"DnaJ homolog subfamily B member 6\",\"id\":\"O75190\"},{\"label\":\"DnaJ homolog subfamily C member 2\",\"id\":\"Q99543\"},{\"label\":\"DnaJ homolog subfamily C member 7\",\"id\":\"Q99615\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Endoplasmic reticulum chaperone BiP\",\"id\":\"P11021\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Heat shock 70 kDa protein 1-like\",\"id\":\"P34931\"},{\"label\":\"Heat shock 70 kDa protein 12A\",\"id\":\"O43301\"},{\"label\":\"Heat shock 70 kDa protein 12B\",\"id\":\"Q96MM6\"},{\"label\":\"Heat shock 70 kDa protein 13\",\"id\":\"P48723\"},{\"label\":\"Heat shock 70 kDa protein 14\",\"id\":\"Q0VDF9\"},{\"label\":\"Heat shock 70 kDa protein 1A\",\"id\":\"P0DMV8\"},{\"label\":\"Heat shock 70 kDa protein 1B\",\"id\":\"P0DMV9\"},{\"label\":\"Heat shock 70 kDa protein 4\",\"id\":\"P34932\"},{\"label\":\"Heat shock 70 kDa protein 4L\",\"id\":\"O95757\"},{\"label\":\"Heat shock 70 kDa protein 6\",\"id\":\"P17066\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Heat shock factor protein 1\",\"id\":\"Q00613\"},{\"label\":\"Heat shock protein 105 kDa\",\"id\":\"Q92598\"},{\"label\":\"Heat shock-related 70 kDa protein 2\",\"id\":\"P54652\"},{\"label\":\"Hsc70-interacting protein\",\"id\":\"P50502\"},{\"label\":\"MAP kinase-activated protein kinase 2\",\"id\":\"P49137\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"NAD-dependent protein deacetylase sirtuin-1\",\"id\":\"Q96EB6\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex 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subunit\",\"id\":\"P27694\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"Serine/threonine-protein kinase ATR\",\"id\":\"Q13535\"},{\"label\":\"Stress-70 protein, mitochondrial\",\"id\":\"P38646\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Organic anion transporters", "protein_name": "[{\"label\":\"Mitochondrial 2-oxoglutarate/malate carrier protein\",\"id\":\"Q02978\"},{\"label\":\"Mitochondrial dicarboxylate carrier\",\"id\":\"Q9UBX3\"},{\"label\":\"Mitochondrial glutamate carrier 1\",\"id\":\"Q9H936\"},{\"label\":\"Mitochondrial glutamate carrier 2\",\"id\":\"Q9H1K4\"},{\"label\":\"Sialin\",\"id\":\"Q9NRA2\"},{\"label\":\"Sodium-coupled monocarboxylate transporter 1\",\"id\":\"Q8N695\"},{\"label\":\"Sodium-dependent phosphate transport protein 1\",\"id\":\"Q14916\"},{\"label\":\"Sodium/iodide cotransporter\",\"id\":\"Q92911\"},{\"label\":\"Tricarboxylate transport protein, mitochondrial\",\"id\":\"P53007\"},{\"label\":\"Vesicular glutamate transporter 1\",\"id\":\"Q9P2U7\"},{\"label\":\"Vesicular glutamate transporter 2\",\"id\":\"Q9P2U8\"},{\"label\":\"Vesicular glutamate transporter 3\",\"id\":\"Q8NDX2\"}]", "uniprot_id": "[\"P53007\",\"Q02978\",\"Q14916\",\"Q8N695\",\"Q8NDX2\",\"Q92911\",\"Q9H1K4\",\"Q9H936\",\"Q9NRA2\",\"Q9P2U7\",\"Q9P2U8\",\"Q9UBX3\"]", "gene_symbol": "[\"AIT\",\"BNPI\",\"DIC\",\"DNPI\",\"GC1\",\"GC2\",\"NIS\",\"NPT1\",\"SLC17A1\",\"SLC17A5\",\"SLC17A6\",\"SLC17A7\",\"SLC17A8\",\"SLC20A3\",\"SLC20A4\",\"SLC25A1\",\"SLC25A10\",\"SLC25A11\",\"SLC25A18\",\"SLC25A22\",\"SLC5A5\",\"SLC5A8\",\"SMCT\",\"SMCT1\",\"VGLUT1\",\"VGLUT2\",\"VGLUT3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PDH complex synthesizes acetyl-CoA from PYR", "protein_name": "[{\"label\":\"Dihydrolipoyl dehydrogenase, mitochondrial\",\"id\":\"P09622\"},{\"label\":\"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial\",\"id\":\"P10515\"},{\"label\":\"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial\",\"id\":\"P08559\"},{\"label\":\"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial\",\"id\":\"P29803\"},{\"label\":\"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial\",\"id\":\"P11177\"},{\"label\":\"Pyruvate dehydrogenase protein X component, mitochondrial\",\"id\":\"O00330\"}]", "uniprot_id": "[\"O00330\",\"P08559\",\"P09622\",\"P10515\",\"P11177\",\"P29803\"]", "gene_symbol": "[\"DLAT\",\"DLD\",\"DLTA\",\"GCSL\",\"LAD\",\"PDHA1\",\"PDHA2\",\"PDHAL\",\"PDHB\",\"PDHX\",\"PDX1\",\"PHE1A\",\"PHE1B\",\"PHE3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ALKBH2 mediated reversal of alkylation damage", "protein_name": "[{\"label\":\"DNA oxidative demethylase ALKBH2\",\"id\":\"Q6NS38\"}]", "uniprot_id": "[\"Q6NS38\"]", "gene_symbol": "[\"ABH2\",\"ALKBH2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MET activates PTK2 signaling", "protein_name": "[{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Hepatocyte growth factor receptor\",\"id\":\"P08581\"},{\"label\":\"Hepatocyte growth factor\",\"id\":\"P14210\"},{\"label\":\"Integrin alpha-2\",\"id\":\"P17301\"},{\"label\":\"Integrin alpha-3\",\"id\":\"P26006\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Laminin subunit alpha-1\",\"id\":\"P25391\"},{\"label\":\"Laminin subunit alpha-2\",\"id\":\"P24043\"},{\"label\":\"Laminin subunit alpha-3\",\"id\":\"Q16787\"},{\"label\":\"Laminin subunit alpha-4\",\"id\":\"Q16363\"},{\"label\":\"Laminin subunit alpha-5\",\"id\":\"O15230\"},{\"label\":\"Laminin subunit beta-1\",\"id\":\"P07942\"},{\"label\":\"Laminin subunit beta-2\",\"id\":\"P55268\"},{\"label\":\"Laminin subunit beta-3\",\"id\":\"Q13751\"},{\"label\":\"Laminin subunit gamma-1\",\"id\":\"P11047\"},{\"label\":\"Laminin subunit gamma-2\",\"id\":\"Q13753\"},{\"label\":\"Laminin subunit gamma-3\",\"id\":\"Q9Y6N6\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"}]", "uniprot_id": 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protein\",\"id\":\"Q9NYM9\"},{\"label\":\"Beta-soluble NSF attachment protein\",\"id\":\"Q9H115\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 1\",\"id\":\"Q8WTW3\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 2\",\"id\":\"Q14746\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 3\",\"id\":\"Q96JB2\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 4\",\"id\":\"Q9H9E3\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 5\",\"id\":\"Q9UP83\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 6\",\"id\":\"Q9Y2V7\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 7\",\"id\":\"P83436\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 8\",\"id\":\"Q96MW5\"},{\"label\":\"Cytohesin-1\",\"id\":\"Q15438\"},{\"label\":\"Cytohesin-2\",\"id\":\"Q99418\"},{\"label\":\"Cytohesin-3\",\"id\":\"O43739\"},{\"label\":\"Cytohesin-4\",\"id\":\"Q9UIA0\"},{\"label\":\"Gamma-soluble NSF attachment 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Rab-39A\",\"id\":\"Q14964\"},{\"label\":\"Ras-related protein Rab-41\",\"id\":\"Q5JT25\"},{\"label\":\"Synaptobrevin homolog YKT6\",\"id\":\"O15498\"},{\"label\":\"Synaptosomal-associated protein 29\",\"id\":\"O95721\"},{\"label\":\"Syntaxin-16\",\"id\":\"O14662\"},{\"label\":\"Syntaxin-5\",\"id\":\"Q13190\"},{\"label\":\"Syntaxin-6\",\"id\":\"O43752\"},{\"label\":\"Thyroid receptor-interacting protein 11\",\"id\":\"Q15643\"},{\"label\":\"Vacuolar protein sorting-associated protein 45\",\"id\":\"Q9NRW7\"},{\"label\":\"Vesicle transport through interaction with t-SNAREs homolog 1A\",\"id\":\"Q96AJ9\"},{\"label\":\"Vesicle-fusing ATPase\",\"id\":\"P46459\"}]", "uniprot_id": 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"[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"14-3-3 protein eta\",\"id\":\"Q04917\"},{\"label\":\"14-3-3 protein gamma\",\"id\":\"P61981\"},{\"label\":\"14-3-3 protein sigma\",\"id\":\"P31947\"},{\"label\":\"14-3-3 protein theta\",\"id\":\"P27348\"},{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"Apoptosis regulator Bcl-2\",\"id\":\"P10415\"},{\"label\":\"BH3-interacting domain death agonist\",\"id\":\"P55957\"},{\"label\":\"Bcl2-associated agonist of cell death\",\"id\":\"Q92934\"},{\"label\":\"Calcineurin subunit B type 1\",\"id\":\"P63098\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform\",\"id\":\"P48454\"}]", "uniprot_id": "[\"P10415\",\"P27348\",\"P31749\",\"P31751\",\"P31946\",\"P31947\",\"P48454\",\"P55957\",\"P61981\",\"P62258\",\"P63098\",\"P63104\",\"Q04917\",\"Q92934\",\"Q9Y243\"]", "gene_symbol": "[\"AKT1\",\"AKT2\",\"AKT3\",\"BAD\",\"BBC6\",\"BCL2\",\"BCL2L8\",\"BID\",\"CALNA3\",\"CNA2\",\"CNA3\",\"CNB\",\"HME1\",\"PKB\",\"PKBG\",\"PPP3CC\",\"PPP3R1\",\"RAC\",\"SFN\",\"YWHA1\",\"YWHAB\",\"YWHAE\",\"YWHAG\",\"YWHAH\",\"YWHAQ\",\"YWHAZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Trafficking of myristoylated proteins to the cilium", "protein_name": "[{\"label\":\"ADP-ribosylation factor-like protein 3\",\"id\":\"P36405\"},{\"label\":\"Cystin-1\",\"id\":\"Q717R9\"},{\"label\":\"Nephrocystin-3\",\"id\":\"Q7Z494\"},{\"label\":\"Protein XRP2\",\"id\":\"O75695\"},{\"label\":\"Protein unc-119 homolog B\",\"id\":\"A6NIH7\"}]", "uniprot_id": "[\"A6NIH7\",\"O75695\",\"P36405\",\"Q717R9\",\"Q7Z494\"]", "gene_symbol": "[\"ARFL3\",\"ARL3\",\"CYS1\",\"KIAA2000\",\"NPHP3\",\"RP2\",\"UNC119B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IRS-related events triggered by IGF1R", "protein_name": "[{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Insulin receptor substrate 4\",\"id\":\"O14654\"},{\"label\":\"Insulin-like growth factor 1 receptor\",\"id\":\"P08069\"},{\"label\":\"Insulin-like growth factor I\",\"id\":\"P05019\"},{\"label\":\"Insulin-like growth factor II\",\"id\":\"P01344\"}]", "uniprot_id": "[\"O14654\",\"P01344\",\"P05019\",\"P08069\",\"P35568\",\"Q9Y4H2\"]", "gene_symbol": "[\"IBP1\",\"IGF1\",\"IGF1R\",\"IGF2\",\"IRS1\",\"IRS2\",\"IRS4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Linoleic acid (LA) metabolism", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family D member 1\",\"id\":\"P33897\"},{\"label\":\"Acyl-CoA (8-3)-desaturase\",\"id\":\"O60427\"},{\"label\":\"Acyl-CoA 6-desaturase\",\"id\":\"O95864\"},{\"label\":\"Long-chain-fatty-acid--CoA ligase 1\",\"id\":\"P33121\"},{\"label\":\"Very long chain fatty acid elongase 1\",\"id\":\"Q9BW60\"},{\"label\":\"Very long chain fatty acid elongase 2\",\"id\":\"Q9NXB9\"},{\"label\":\"Very long chain fatty acid elongase 3\",\"id\":\"Q9HB03\"},{\"label\":\"Very long chain fatty acid elongase 5\",\"id\":\"Q9NYP7\"}]", "uniprot_id": "[\"O60427\",\"O95864\",\"P33121\",\"P33897\",\"Q9BW60\",\"Q9HB03\",\"Q9NXB9\",\"Q9NYP7\"]", "gene_symbol": "[\"ABCD1\",\"ACSL1\",\"ALD\",\"CIG30\",\"ELG3\",\"ELOVL1\",\"ELOVL2\",\"ELOVL3\",\"ELOVL5\",\"FACL1\",\"FACL2\",\"FADS1\",\"FADS2\",\"FADSD5\",\"LACS\",\"LACS1\",\"LACS2\",\"SSC1\",\"SSC2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "protein_name": "[{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Platelet-derived growth factor receptor alpha\",\"id\":\"P16234\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O00459\",\"P01111\",\"P01112\",\"P16234\",\"P27986\",\"P40763\",\"P42224\",\"P42336\",\"P42338\",\"Q07889\"]", "gene_symbol": "[\"APRF\",\"GRB1\",\"HRAS\",\"HRAS1\",\"NRAS\",\"PDGFR2\",\"PDGFRA\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3R1\",\"PIK3R2\",\"RHEPDGFRA\",\"SOS1\",\"STAT1\",\"STAT3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transport of glycerol from adipocytes to the liver by Aquaporins", "protein_name": "[{\"label\":\"Aquaporin-7\",\"id\":\"O14520\"},{\"label\":\"Aquaporin-9\",\"id\":\"O43315\"}]", "uniprot_id": "[\"O14520\",\"O43315\"]", "gene_symbol": "[\"AQP7\",\"AQP7L\",\"AQP9\",\"SSC1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Erythrocytes take up carbon dioxide and release oxygen", "protein_name": "[{\"label\":\"Ammonium transporter Rh type A\",\"id\":\"Q02094\"},{\"label\":\"Aquaporin-1\",\"id\":\"P29972\"},{\"label\":\"Band 3 anion transport protein\",\"id\":\"P02730\"},{\"label\":\"Carbonic anhydrase 1\",\"id\":\"P00915\"},{\"label\":\"Carbonic anhydrase 2\",\"id\":\"P00918\"},{\"label\":\"Carbonic anhydrase 4\",\"id\":\"P22748\"},{\"label\":\"Cytochrome b5 reductase 4\",\"id\":\"Q7L1T6\"},{\"label\":\"Hemoglobin subunit alpha\",\"id\":\"P69905\"},{\"label\":\"Hemoglobin subunit beta\",\"id\":\"P68871\"},{\"label\":\"NADH-cytochrome b5 reductase 1\",\"id\":\"Q9UHQ9\"},{\"label\":\"NADH-cytochrome b5 reductase 2\",\"id\":\"Q6BCY4\"},{\"label\":\"NADH-cytochrome b5 reductase-like\",\"id\":\"Q6IPT4\"}]", "uniprot_id": "[\"P00915\",\"P00918\",\"P02730\",\"P22748\",\"P29972\",\"P68871\",\"P69905\",\"Q02094\",\"Q6BCY4\",\"Q6IPT4\",\"Q7L1T6\",\"Q9UHQ9\"]", "gene_symbol": "[\"AE1\",\"AQP1\",\"CA1\",\"CA2\",\"CA4\",\"CHIP28\",\"CYB5R1\",\"CYB5R2\",\"CYB5R4\",\"CYB5RL\",\"DI\",\"EPB3\",\"HBA1\",\"HBA2\",\"HBB\",\"NCB5OR\",\"NQO3A2\",\"RH50\",\"RHAG\",\"SLC4A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "protein_name": "[{\"label\":\"Apolipoprotein E\",\"id\":\"P02649\"},{\"label\":\"Protein DEK\",\"id\":\"P35659\"},{\"label\":\"Transcription factor AP-2-alpha\",\"id\":\"P05549\"}]", "uniprot_id": "[\"P02649\",\"P05549\",\"P35659\"]", "gene_symbol": "[\"AP2TF\",\"APOE\",\"DEK\",\"TFAP2\",\"TFAP2A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Adrenaline,noradrenaline inhibits insulin secretion", "protein_name": 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G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-1\",\"id\":\"P63096\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-2\",\"id\":\"P04899\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit alpha-1C\",\"id\":\"Q13936\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit alpha-1D\",\"id\":\"Q01668\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-2\",\"id\":\"Q08289\"},{\"label\":\"Voltage-dependent L-type calcium channel subunit beta-3\",\"id\":\"P54284\"},{\"label\":\"Voltage-dependent calcium channel subunit alpha-2/delta-2\",\"id\":\"Q9NY47\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O43306\",\"O60262\",\"O95622\",\"P04899\",\"P08913\",\"P16520\",\"P18825\",\"P50150\",\"P50151\",\"P54284\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63096\",\"P63211\",\"P63215\",\"P63218\",\"Q01668\",\"Q08289\",\"Q13936\",\"Q9HAV0\",\"Q9NY47\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": "[\"ADCY5\",\"ADCY6\",\"ADRA2A\",\"ADRA2C\",\"ADRA2L2\",\"ADRA2R\",\"ADRA2RL2\",\"ADRAR\",\"CACH2\",\"CACH3\",\"CACN2\",\"CACN4\",\"CACNA1C\",\"CACNA1D\",\"CACNA2D2\",\"CACNB2\",\"CACNB3\",\"CACNL1A1\",\"CACNL1A2\",\"CACNLB2\",\"CACNLB3\",\"CCHL1A1\",\"CCHL1A2\",\"GNAI1\",\"GNAI2\",\"GNAI2B\",\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNB5\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT1\",\"GNGT10\",\"GNGT11\",\"GNGT2\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT8\",\"GNGT9\",\"KIAA0422\",\"KIAA0558\",\"MYSB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TP53 Regulates Metabolic Genes", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"14-3-3 protein eta\",\"id\":\"Q04917\"},{\"label\":\"14-3-3 protein gamma\",\"id\":\"P61981\"},{\"label\":\"14-3-3 protein sigma\",\"id\":\"P31947\"},{\"label\":\"14-3-3 protein theta\",\"id\":\"P27348\"},{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-1\",\"id\":\"Q13131\"},{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-2\",\"id\":\"P54646\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-1\",\"id\":\"Q9Y478\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-2\",\"id\":\"O43741\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-1\",\"id\":\"P54619\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-2\",\"id\":\"Q9UGJ0\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-3\",\"id\":\"Q9UGI9\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Cytochrome c oxidase subunit 1\",\"id\":\"P00395\"},{\"label\":\"Cytochrome c oxidase subunit 2\",\"id\":\"P00403\"},{\"label\":\"Cytochrome c oxidase subunit 3\",\"id\":\"P00414\"},{\"label\":\"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial\",\"id\":\"P13073\"},{\"label\":\"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial\",\"id\":\"Q96KJ9\"},{\"label\":\"Cytochrome c oxidase subunit 5A, mitochondrial\",\"id\":\"P20674\"},{\"label\":\"Cytochrome c oxidase subunit 5B, mitochondrial\",\"id\":\"P10606\"},{\"label\":\"Cytochrome c oxidase subunit 6A1, mitochondrial\",\"id\":\"P12074\"},{\"label\":\"Cytochrome c oxidase subunit 6A2, mitochondrial\",\"id\":\"Q02221\"},{\"label\":\"Cytochrome c oxidase subunit 6B1\",\"id\":\"P14854\"},{\"label\":\"Cytochrome c oxidase subunit 6B2\",\"id\":\"Q6YFQ2\"},{\"label\":\"Cytochrome c oxidase subunit 6C\",\"id\":\"P09669\"},{\"label\":\"Cytochrome c oxidase subunit 7A-related protein, mitochondrial\",\"id\":\"O14548\"},{\"label\":\"Cytochrome c oxidase subunit 7A1, mitochondrial\",\"id\":\"P24310\"},{\"label\":\"Cytochrome c oxidase subunit 7A2, mitochondrial\",\"id\":\"P14406\"},{\"label\":\"Cytochrome c oxidase subunit 7B, mitochondrial\",\"id\":\"P24311\"},{\"label\":\"Cytochrome c oxidase subunit 7C, mitochondrial\",\"id\":\"P15954\"},{\"label\":\"Cytochrome c oxidase subunit 8A, mitochondrial\",\"id\":\"P10176\"},{\"label\":\"Cytochrome c oxidase subunit 8C, mitochondrial\",\"id\":\"Q7Z4L0\"},{\"label\":\"Cytochrome c oxidase subunit NDUFA4\",\"id\":\"O00483\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"DNA damage-inducible transcript 4 protein\",\"id\":\"Q9NX09\"},{\"label\":\"Fructose-2,6-bisphosphatase TIGAR\",\"id\":\"Q9NQ88\"},{\"label\":\"GTP-binding protein Rheb\",\"id\":\"Q15382\"},{\"label\":\"Glucose-6-phosphate 1-dehydrogenase\",\"id\":\"P11413\"},{\"label\":\"Glucose-6-phosphate isomerase\",\"id\":\"P06744\"},{\"label\":\"Glutaminase kidney isoform, mitochondrial\",\"id\":\"O94925\"},{\"label\":\"Glutaminase liver isoform, mitochondrial\",\"id\":\"Q9UI32\"},{\"label\":\"Glutathione peroxidase 2\",\"id\":\"P18283\"},{\"label\":\"HIG1 domain family member 1C\",\"id\":\"A8MV81\"},{\"label\":\"Hamartin\",\"id\":\"Q92574\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Neutral amino acid transporter 9\",\"id\":\"Q8NBW4\"},{\"label\":\"Peroxiredoxin-1\",\"id\":\"Q06830\"},{\"label\":\"Peroxiredoxin-2\",\"id\":\"P32119\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN\",\"id\":\"P60484\"},{\"label\":\"Protein SCO2 homolog, mitochondrial\",\"id\":\"O43819\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Ragulator complex protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective UGT1A4 causes hyperbilirubinemia", "protein_name": "[{\"label\":\"UDP-glucuronosyltransferase 1A4\",\"id\":\"P22310\"}]", "uniprot_id": "[\"P22310\"]", "gene_symbol": "[\"GNT1\",\"UGT1\",\"UGT1A4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "protein_name": "[{\"label\":\"AT-rich interactive domain-containing protein 3A\",\"id\":\"Q99856\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Cyclin-A1\",\"id\":\"P78396\"},{\"label\":\"Cyclin-A2\",\"id\":\"P20248\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"G1/S-specific cyclin-E1\",\"id\":\"P24864\"},{\"label\":\"G1/S-specific cyclin-E2\",\"id\":\"O96020\"},{\"label\":\"Poly(rC)-binding protein 4\",\"id\":\"P57723\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Transcription factor E2F7\",\"id\":\"Q96AV8\"},{\"label\":\"Transcription factor E2F8\",\"id\":\"A0AVK6\"},{\"label\":\"Zinc finger protein 385A\",\"id\":\"Q96PM9\"}]", "uniprot_id": "[\"A0AVK6\",\"O96020\",\"P04637\",\"P20248\",\"P24864\",\"P24941\",\"P38936\",\"P46527\",\"P57723\",\"P78396\",\"Q01094\",\"Q96AV8\",\"Q96PM9\",\"Q99856\"]", "gene_symbol": "[\"ARID3A\",\"CAP20\",\"CCN1\",\"CCNA\",\"CCNA1\",\"CCNA2\",\"CCNE\",\"CCNE1\",\"CCNE2\",\"CDK2\",\"CDKN1\",\"CDKN1A\",\"CDKN1B\",\"CDKN2\",\"CIP1\",\"DRIL1\",\"DRIL3\",\"DRX\",\"E2F1\",\"E2F7\",\"E2F8\",\"E2FBP1\",\"HZF\",\"KIP1\",\"MDA6\",\"P53\",\"PCBP4\",\"PIC1\",\"RBBP3\",\"RZF\",\"SDI1\",\"TP53\",\"WAF1\",\"ZNF385\",\"ZNF385A\",\"p27\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Expression and translocation of olfactory receptors", "protein_name": "[{\"label\":\"LIM domain-binding protein 1\",\"id\":\"Q86U70\"},{\"label\":\"LIM/homeobox protein Lhx2\",\"id\":\"P50458\"},{\"label\":\"Olfactory receptor 10A2\",\"id\":\"Q9H208\"},{\"label\":\"Olfactory receptor 10A3\",\"id\":\"P58181\"},{\"label\":\"Olfactory receptor 10A4\",\"id\":\"Q9H209\"},{\"label\":\"Olfactory receptor 10A5\",\"id\":\"Q9H207\"},{\"label\":\"Olfactory receptor 10A6\",\"id\":\"Q8NH74\"},{\"label\":\"Olfactory receptor 10A7\",\"id\":\"Q8NGE5\"},{\"label\":\"Olfactory receptor 10AC1\",\"id\":\"Q8NH08\"},{\"label\":\"Olfactory receptor 10AD1\",\"id\":\"Q8NGE0\"},{\"label\":\"Olfactory receptor 10AG1\",\"id\":\"Q8NH19\"},{\"label\":\"Olfactory receptor 10C1\",\"id\":\"Q96KK4\"},{\"label\":\"Olfactory receptor 10D3\",\"id\":\"Q8NH80\"},{\"label\":\"Olfactory receptor 10G2\",\"id\":\"Q8NGC3\"},{\"label\":\"Olfactory receptor 10G3\",\"id\":\"Q8NGC4\"},{\"label\":\"Olfactory receptor 10G4\",\"id\":\"Q8NGN3\"},{\"label\":\"Olfactory receptor 10G6\",\"id\":\"Q8NH81\"},{\"label\":\"Olfactory receptor 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1A1\",\"id\":\"Q9P1Q5\"},{\"label\":\"Olfactory receptor 1A2\",\"id\":\"Q9Y585\"},{\"label\":\"Olfactory receptor 1B1\",\"id\":\"Q8NGR6\"},{\"label\":\"Olfactory receptor 1C1\",\"id\":\"Q15619\"},{\"label\":\"Olfactory receptor 1D2\",\"id\":\"P34982\"},{\"label\":\"Olfactory receptor 1D4\",\"id\":\"P47884\"},{\"label\":\"Olfactory receptor 1D5\",\"id\":\"P58170\"},{\"label\":\"Olfactory receptor 1E1\",\"id\":\"P30953\"},{\"label\":\"Olfactory receptor 1E2\",\"id\":\"P47887\"},{\"label\":\"Olfactory receptor 1E3\",\"id\":\"Q8WZA6\"},{\"label\":\"Olfactory receptor 1F1\",\"id\":\"O43749\"},{\"label\":\"Olfactory receptor 1G1\",\"id\":\"P47890\"},{\"label\":\"Olfactory receptor 1I1\",\"id\":\"O60431\"},{\"label\":\"Olfactory receptor 1J1\",\"id\":\"Q8NGS3\"},{\"label\":\"Olfactory receptor 1J2\",\"id\":\"Q8NGS2\"},{\"label\":\"Olfactory receptor 1J4\",\"id\":\"Q8NGS1\"},{\"label\":\"Olfactory receptor 1K1\",\"id\":\"Q8NGR3\"},{\"label\":\"Olfactory receptor 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2A4\",\"id\":\"O95047\"},{\"label\":\"Olfactory receptor 2A5\",\"id\":\"Q96R48\"},{\"label\":\"Olfactory receptor 2A7\",\"id\":\"Q96R45\"},{\"label\":\"Olfactory receptor 2AE1\",\"id\":\"Q8NHA4\"},{\"label\":\"Olfactory receptor 2AG1\",\"id\":\"Q9H205\"},{\"label\":\"Olfactory receptor 2AG2\",\"id\":\"A6NM03\"},{\"label\":\"Olfactory receptor 2AJ1\",\"id\":\"Q8NGZ0\"},{\"label\":\"Olfactory receptor 2AK2\",\"id\":\"Q8NG84\"},{\"label\":\"Olfactory receptor 2AP1\",\"id\":\"Q8NGE2\"},{\"label\":\"Olfactory receptor 2AT4\",\"id\":\"A6NND4\"},{\"label\":\"Olfactory receptor 2B11\",\"id\":\"Q5JQS5\"},{\"label\":\"Olfactory receptor 2B2\",\"id\":\"Q9GZK3\"},{\"label\":\"Olfactory receptor 2B6\",\"id\":\"P58173\"},{\"label\":\"Olfactory receptor 2C1\",\"id\":\"O95371\"},{\"label\":\"Olfactory receptor 2C3\",\"id\":\"Q8N628\"},{\"label\":\"Olfactory receptor 2D2\",\"id\":\"Q9H210\"},{\"label\":\"Olfactory receptor 2D3\",\"id\":\"Q8NGH3\"},{\"label\":\"Olfactory receptor 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2M3\",\"id\":\"Q8NG83\"},{\"label\":\"Olfactory receptor 2M4\",\"id\":\"Q96R27\"},{\"label\":\"Olfactory receptor 2M5\",\"id\":\"A3KFT3\"},{\"label\":\"Olfactory receptor 2M7\",\"id\":\"Q8NG81\"},{\"label\":\"Olfactory receptor 2S2\",\"id\":\"Q9NQN1\"},{\"label\":\"Olfactory receptor 2T10\",\"id\":\"Q8NGZ9\"},{\"label\":\"Olfactory receptor 2T11\",\"id\":\"Q8NH01\"},{\"label\":\"Olfactory receptor 2T12\",\"id\":\"Q8NG77\"},{\"label\":\"Olfactory receptor 2T1\",\"id\":\"O43869\"},{\"label\":\"Olfactory receptor 2T27\",\"id\":\"Q8NH04\"},{\"label\":\"Olfactory receptor 2T29\",\"id\":\"Q8NH02\"},{\"label\":\"Olfactory receptor 2T2\",\"id\":\"Q6IF00\"},{\"label\":\"Olfactory receptor 2T33\",\"id\":\"Q8NG76\"},{\"label\":\"Olfactory receptor 2T34\",\"id\":\"Q8NGX1\"},{\"label\":\"Olfactory receptor 2T35\",\"id\":\"Q8NGX2\"},{\"label\":\"Olfactory receptor 2T3\",\"id\":\"Q8NH03\"},{\"label\":\"Olfactory receptor 2T4\",\"id\":\"Q8NH00\"},{\"label\":\"Olfactory receptor 2T5\",\"id\":\"Q6IEZ7\"},{\"label\":\"Olfactory receptor 2T6\",\"id\":\"Q8NHC8\"},{\"label\":\"Olfactory receptor 2T7\",\"id\":\"P0C7T2\"},{\"label\":\"Olfactory receptor 2T8\",\"id\":\"A6NH00\"},{\"label\":\"Olfactory receptor 2V1\",\"id\":\"Q8NHB1\"},{\"label\":\"Olfactory receptor 2V2\",\"id\":\"Q96R30\"},{\"label\":\"Olfactory receptor 2W1\",\"id\":\"Q9Y3N9\"},{\"label\":\"Olfactory receptor 2W3\",\"id\":\"Q7Z3T1\"},{\"label\":\"Olfactory receptor 2Y1\",\"id\":\"Q8NGV0\"},{\"label\":\"Olfactory receptor 2Z1\",\"id\":\"Q8NG97\"},{\"label\":\"Olfactory receptor 3A1\",\"id\":\"P47881\"},{\"label\":\"Olfactory receptor 3A2\",\"id\":\"P47893\"},{\"label\":\"Olfactory receptor 3A3\",\"id\":\"P47888\"},{\"label\":\"Olfactory receptor 4A15\",\"id\":\"Q8NGL6\"},{\"label\":\"Olfactory receptor 4A16\",\"id\":\"Q8NH70\"},{\"label\":\"Olfactory receptor 4A47\",\"id\":\"Q6IF82\"},{\"label\":\"Olfactory receptor 4A5\",\"id\":\"Q8NH83\"},{\"label\":\"Olfactory receptor 4A8\",\"id\":\"P0C604\"},{\"label\":\"Olfactory receptor 4B1\",\"id\":\"Q8NGF8\"},{\"label\":\"Olfactory receptor 4C11\",\"id\":\"Q6IEV9\"},{\"label\":\"Olfactory receptor 4C12\",\"id\":\"Q96R67\"},{\"label\":\"Olfactory receptor 4C13\",\"id\":\"Q8NGP0\"},{\"label\":\"Olfactory receptor 4C15\",\"id\":\"Q8NGM1\"},{\"label\":\"Olfactory receptor 4C16\",\"id\":\"Q8NGL9\"},{\"label\":\"Olfactory receptor 4C3\",\"id\":\"Q8NH37\"},{\"label\":\"Olfactory receptor 4C45\",\"id\":\"A6NMZ5\"},{\"label\":\"Olfactory receptor 4C46\",\"id\":\"A6NHA9\"},{\"label\":\"Olfactory receptor 4C5\",\"id\":\"Q8NGB2\"},{\"label\":\"Olfactory receptor 4C6\",\"id\":\"Q8NH72\"},{\"label\":\"Olfactory receptor 4D10\",\"id\":\"Q8NGI6\"},{\"label\":\"Olfactory receptor 4D11\",\"id\":\"Q8NGI4\"},{\"label\":\"Olfactory receptor 4D1\",\"id\":\"Q15615\"},{\"label\":\"Olfactory receptor 4D2\",\"id\":\"P58180\"},{\"label\":\"Olfactory receptor 4D5\",\"id\":\"Q8NGN0\"},{\"label\":\"Olfactory receptor 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3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"E3 ubiquitin-protein ligase Mdm2\",\"id\":\"Q00987\"},{\"label\":\"E3 ubiquitin-protein ligase SMURF1\",\"id\":\"Q9HCE7\"},{\"label\":\"E3 ubiquitin-protein ligase SMURF2\",\"id\":\"Q9HAU4\"},{\"label\":\"Histone acetyltransferase 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activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Somatotropin\",\"id\":\"P01241\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O60674\",\"P01236\",\"P01241\",\"P01242\",\"P0DML2\",\"P10912\",\"P16471\",\"P42229\",\"P51692\",\"P62877\",\"P63208\",\"Q06124\",\"Q13616\",\"Q9Y297\"]", "gene_symbol": "[\"BTRC\",\"BTRCP\",\"CSH1\",\"CUL1\",\"EMC19\",\"FBW1A\",\"FBXW1A\",\"GH1\",\"GH2\",\"GHR\",\"JAK2\",\"OCP2\",\"PRL\",\"PRLR\",\"PTP2C\",\"PTPN11\",\"RBX1\",\"RNF75\",\"ROC1\",\"SHPTP2\",\"SKP1\",\"SKP1A\",\"STAT5\",\"STAT5A\",\"STAT5B\",\"TCEB1L\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Apoptotic factor-mediated response", "protein_name": "[{\"label\":\"Complement component 1 Q subcomponent-binding protein, mitochondrial\",\"id\":\"Q07021\"},{\"label\":\"Tumor suppressor ARF\",\"id\":\"Q8N726\"}]", "uniprot_id": "[\"Q07021\",\"Q8N726\"]", "gene_symbol": "[\"C1QBP\",\"CDKN2\",\"CDKN2A\",\"GC1QBP\",\"HABP1\",\"MLM\",\"SF2P32\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "WNT ligand biogenesis and trafficking", "protein_name": "[{\"label\":\"Protein Wnt-10a\",\"id\":\"Q9GZT5\"},{\"label\":\"Protein Wnt-10b\",\"id\":\"O00744\"},{\"label\":\"Protein Wnt-11\",\"id\":\"O96014\"},{\"label\":\"Protein Wnt-16\",\"id\":\"Q9UBV4\"},{\"label\":\"Protein Wnt-2\",\"id\":\"P09544\"},{\"label\":\"Protein Wnt-2b\",\"id\":\"Q93097\"},{\"label\":\"Protein Wnt-3a\",\"id\":\"P56704\"},{\"label\":\"Protein Wnt-4\",\"id\":\"P56705\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Protein Wnt-5b\",\"id\":\"Q9H1J7\"},{\"label\":\"Protein Wnt-6\",\"id\":\"Q9Y6F9\"},{\"label\":\"Protein Wnt-7a\",\"id\":\"O00755\"},{\"label\":\"Protein Wnt-7b\",\"id\":\"P56706\"},{\"label\":\"Protein Wnt-8a\",\"id\":\"Q9H1J5\"},{\"label\":\"Protein 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transporter\",\"id\":\"Q05940\"},{\"label\":\"Synaptosomal-associated protein 25\",\"id\":\"P60880\"},{\"label\":\"Synaptotagmin-1\",\"id\":\"P21579\"},{\"label\":\"Syntaxin-1A\",\"id\":\"Q16623\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"}]", "uniprot_id": "[\"O14795\",\"O14810\",\"O14910\",\"O14936\",\"O14994\",\"O75145\",\"O75334\",\"O75335\",\"O95153\",\"P17600\",\"P20336\",\"P21579\",\"P60880\",\"P63027\",\"Q02410\",\"Q05940\",\"Q13136\",\"Q16623\",\"Q86UR5\",\"Q92777\",\"Q9HAP6\",\"Q9NUP9\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Intestinal hexose absorption", "protein_name": "[{\"label\":\"Regulatory solute carrier protein family 1 member 1\",\"id\":\"Q92681\"},{\"label\":\"Sodium/glucose cotransporter 1\",\"id\":\"P13866\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 2\",\"id\":\"P11168\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 5\",\"id\":\"P22732\"}]", "uniprot_id": "[\"P11168\",\"P13866\",\"P22732\",\"Q92681\"]", "gene_symbol": "[\"GLUT2\",\"GLUT5\",\"NAGT\",\"RSC1A1\",\"SGLT1\",\"SLC2A2\",\"SLC2A5\",\"SLC5A1\"]", "gtc_id": "[\"G58161NS\",\"G93924TT\"]" }, { "pathway_label": "Ubiquinol biosynthesis", "protein_name": "[{\"label\":\"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial\",\"id\":\"Q5HYK3\"},{\"label\":\"4-hydroxybenzoate polyprenyltransferase, mitochondrial\",\"id\":\"Q96H96\"},{\"label\":\"4-hydroxyphenylpyruvate dioxygenase-like 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protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00141\",\"O15151\",\"O15530\",\"O75604\",\"O96017\",\"P04637\",\"P06493\",\"P0CG47\",\"P0CG48\",\"P20248\",\"P24941\",\"P30153\",\"P30154\",\"P31749\",\"P31751\",\"P42345\",\"P51959\",\"P62714\",\"P62979\",\"P62987\",\"P67775\",\"P78396\",\"P85299\",\"Q00987\",\"Q13315\",\"Q13362\",\"Q6R327\",\"Q8N726\",\"Q8WZ73\",\"Q93009\",\"Q969K3\",\"Q9BPZ7\",\"Q9BVC4\",\"Q9BVI0\",\"Q9UER7\",\"Q9Y243\"]", "gene_symbol": 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HINT2\",\"id\":\"Q9BX68\"},{\"label\":\"Alpha-actinin-1\",\"id\":\"P12814\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Cell surface glycoprotein MUC18\",\"id\":\"P43121\"},{\"label\":\"Copine-8\",\"id\":\"Q86YQ8\"},{\"label\":\"DEP domain-containing protein 1B\",\"id\":\"Q8WUY9\"},{\"label\":\"Delta(14)-sterol reductase LBR\",\"id\":\"Q14739\"},{\"label\":\"Drebrin\",\"id\":\"Q16643\"},{\"label\":\"EF-hand domain-containing protein D2\",\"id\":\"Q96C19\"},{\"label\":\"Emerin\",\"id\":\"P50402\"},{\"label\":\"Extended synaptotagmin-1\",\"id\":\"Q9BSJ8\"},{\"label\":\"F-actin-capping protein subunit beta\",\"id\":\"P47756\"},{\"label\":\"Filamin-A-interacting protein 1\",\"id\":\"Q7Z7B0\"},{\"label\":\"Gamma-adducin\",\"id\":\"Q9UEY8\"},{\"label\":\"Golgin subfamily A member 8R\",\"id\":\"I6L899\"},{\"label\":\"Inner nuclear membrane protein Man1\",\"id\":\"Q9Y2U8\"},{\"label\":\"Lamin-B1\",\"id\":\"P20700\"},{\"label\":\"Lamina-associated polypeptide 2, isoforms beta/gamma\",\"id\":\"P42167\"},{\"label\":\"Membrane-associated progesterone receptor component 2\",\"id\":\"O15173\"},{\"label\":\"Metalloreductase STEAP3\",\"id\":\"Q658P3\"},{\"label\":\"Motile sperm domain-containing protein 2\",\"id\":\"Q8NHP6\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Plexin-A1\",\"id\":\"Q9UIW2\"},{\"label\":\"Plexin-B1\",\"id\":\"O43157\"},{\"label\":\"Protein ERGIC-53\",\"id\":\"P49257\"},{\"label\":\"Protein diaphanous homolog 1\",\"id\":\"O60610\"},{\"label\":\"Protein diaphanous homolog 3\",\"id\":\"Q9NSV4\"},{\"label\":\"Rabankyrin-5\",\"id\":\"Q9P2R3\"},{\"label\":\"Rac GTPase-activating protein 1\",\"id\":\"Q9H0H5\"},{\"label\":\"Ras-related protein Rab-7a\",\"id\":\"P51149\"},{\"label\":\"Rho GTPase-activating protein 12\",\"id\":\"Q8IWW6\"},{\"label\":\"Rho GTPase-activating protein 17\",\"id\":\"Q68EM7\"},{\"label\":\"Rho GTPase-activating protein 1\",\"id\":\"Q07960\"},{\"label\":\"Rho GTPase-activating protein 21\",\"id\":\"Q5T5U3\"},{\"label\":\"Rho GTPase-activating protein 26\",\"id\":\"Q9UNA1\"},{\"label\":\"Rho GTPase-activating protein 32\",\"id\":\"A7KAX9\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho GTPase-activating protein 39\",\"id\":\"Q9C0H5\"},{\"label\":\"Rho GTPase-activating protein 5\",\"id\":\"Q13017\"},{\"label\":\"Rho-related GTP-binding protein RhoD\",\"id\":\"O00212\"},{\"label\":\"Serine/threonine-protein kinase PAK 5\",\"id\":\"Q9P286\"},{\"label\":\"Serine/threonine-protein kinase PAK 6\",\"id\":\"Q9NQU5\"},{\"label\":\"Serine/threonine-protein kinase VRK2\",\"id\":\"Q86Y07\"},{\"label\":\"Sodium bicarbonate cotransporter 3\",\"id\":\"Q9Y6M7\"},{\"label\":\"Starch-binding domain-containing protein 1\",\"id\":\"O95210\"},{\"label\":\"Torsin-1A-interacting protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)", "protein_name": "[{\"label\":\"Vasopressin V1a receptor\",\"id\":\"P37288\"},{\"label\":\"Vasopressin V1b receptor\",\"id\":\"P47901\"},{\"label\":\"Vasopressin-neurophysin 2-copeptin\",\"id\":\"P01185\"}]", "uniprot_id": "[\"P01185\",\"P37288\",\"P47901\"]", "gene_symbol": "[\"ARVP\",\"AVP\",\"AVPR1\",\"AVPR1A\",\"AVPR1B\",\"AVPR3\",\"VP\",\"VPR3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Intestinal saccharidase deficiencies", "protein_name": "[{\"label\":\"Lactase/phlorizin hydrolase\",\"id\":\"P09848\"},{\"label\":\"Sucrase-isomaltase, intestinal\",\"id\":\"P14410\"}]", "uniprot_id": "[\"P09848\",\"P14410\"]", "gene_symbol": "[\"LCT\",\"LPH\",\"SI\"]", "gtc_id": "[\"G74621DY\",\"G96370VA\"]" }, { "pathway_label": "Release of apoptotic factors from the mitochondria", "protein_name": "[{\"label\":\"Apoptosis regulator BAX\",\"id\":\"Q07812\"},{\"label\":\"Bcl-2 homologous antagonist/killer\",\"id\":\"Q16611\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"Diablo IAP-binding mitochondrial protein\",\"id\":\"Q9NR28\"},{\"label\":\"Gasdermin-D\",\"id\":\"P57764\"},{\"label\":\"Gasdermin-E\",\"id\":\"O60443\"}]", "uniprot_id": "[\"O60443\",\"P57764\",\"P99999\",\"Q07812\",\"Q16611\",\"Q9NR28\"]", "gene_symbol": "[\"BAK\",\"BAK1\",\"BAX\",\"BCL2L4\",\"BCL2L7\",\"CDN1\",\"CYC\",\"CYCS\",\"DFNA5\",\"DFNA5L\",\"DIABLO\",\"GSDMD\",\"GSDMDC1\",\"GSDME\",\"ICERE1\",\"SMAC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Oncogene Induced Senescence", "protein_name": "[{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor B\",\"id\":\"P42772\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor C\",\"id\":\"P42773\"},{\"label\":\"Cyclin-dependent kinase 4 inhibitor D\",\"id\":\"P55273\"},{\"label\":\"Cyclin-dependent kinase 4\",\"id\":\"P11802\"},{\"label\":\"Cyclin-dependent kinase 6\",\"id\":\"Q00534\"},{\"label\":\"Cyclin-dependent kinase inhibitor 2A\",\"id\":\"P42771\"},{\"label\":\"DNA-binding protein inhibitor ID-1\",\"id\":\"P41134\"},{\"label\":\"E3 ubiquitin-protein ligase Mdm2\",\"id\":\"Q00987\"},{\"label\":\"ETS domain-containing transcription factor ERF\",\"id\":\"P50548\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein C-ets-1\",\"id\":\"P14921\"},{\"label\":\"Protein C-ets-2\",\"id\":\"P15036\"},{\"label\":\"Protein Mdm4\",\"id\":\"O15151\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Transcription factor E2F2\",\"id\":\"Q14209\"},{\"label\":\"Transcription factor E2F3\",\"id\":\"O00716\"},{\"label\":\"Transcription factor Sp1\",\"id\":\"P08047\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"},{\"label\":\"Tumor suppressor ARF\",\"id\":\"Q8N726\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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"[\"AGO1\",\"AGO3\",\"AGO4\",\"BHLHB24\",\"CAGH26\",\"CDK4\",\"CDK6\",\"CDKN2\",\"CDKN2A\",\"CDKN2B\",\"CDKN2C\",\"CDKN2D\",\"CDKN6\",\"DP1\",\"DP2\",\"E2F1\",\"E2F2\",\"E2F3\",\"EIF2C1\",\"EIF2C3\",\"EIF2C4\",\"ERF\",\"ERK1\",\"ERK2\",\"ETS1\",\"ETS2\",\"EWSR2\",\"ID\",\"ID1\",\"KIAA0075\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"KIAA1631\",\"MAPK1\",\"MAPK3\",\"MDM2\",\"MDM4\",\"MDMX\",\"MLM\",\"MOV10\",\"MTS1\",\"MTS2\",\"P53\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"RB1\",\"RBBP3\",\"RPS27A\",\"SP1\",\"TFDP1\",\"TFDP2\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\",\"TP53\",\"TSFP1\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "UNC93B1 deficiency - HSE", "protein_name": "[{\"label\":\"Protein unc-93 homolog B1\",\"id\":\"Q9H1C4\"},{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"}]", "uniprot_id": "[\"O15455\",\"Q9H1C4\"]", "gene_symbol": "[\"TLR3\",\"UNC93\",\"UNC93B\",\"UNC93B1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NGF processing", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Proprotein convertase subtilisin/kexin type 5\",\"id\":\"Q92824\"},{\"label\":\"Proprotein convertase subtilisin/kexin type 6\",\"id\":\"P29122\"}]", "uniprot_id": "[\"P01138\",\"P09958\",\"P29122\",\"Q92824\"]", "gene_symbol": "[\"FUR\",\"FURIN\",\"NGF\",\"NGFB\",\"PACE\",\"PACE4\",\"PC5\",\"PC6\",\"PCSK3\",\"PCSK5\",\"PCSK6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Constitutive Signaling by EGFRvIII", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"P00533\",\"P01111\",\"P01112\",\"P01133\",\"P07900\",\"P19174\",\"P22681\",\"P27986\",\"P29353\",\"P42336\",\"Q07889\",\"Q13480\",\"Q16543\"]", "gene_symbol": "[\"CBL\",\"CBL2\",\"CDC37\",\"CDC37A\",\"EGF\",\"EGFR\",\"ERBB\",\"ERBB1\",\"GAB1\",\"GRB1\",\"HER1\",\"HRAS\",\"HRAS1\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"NRAS\",\"PIK3CA\",\"PIK3R1\",\"PLC1\",\"PLCG1\",\"RNF55\",\"SHC\",\"SHC1\",\"SHCA\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SLC15A4:TASL-dependent IRF5 activation", "protein_name": "[{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Interferon regulatory factor 5\",\"id\":\"Q13568\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"Solute carrier family 15 member 4\",\"id\":\"Q8N697\"},{\"label\":\"TLR adapter interacting with SLC15A4 on the lysosome\",\"id\":\"Q9HAI6\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"Q13568\",\"Q8N697\",\"Q9HAI6\",\"Q9Y6K9\"]", "gene_symbol": "[\"CHUK\",\"CXorf21\",\"FIP3\",\"IKBKB\",\"IKBKG\",\"IKKA\",\"IKKB\",\"IRF5\",\"NEMO\",\"PHT1\",\"PTR4\",\"SLC15A4\",\"TASL\",\"TCF16\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PI3K events in ERBB4 signaling", "protein_name": "[{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"}]", "uniprot_id": "[\"O14511\",\"O14944\",\"P27986\",\"P35070\",\"P42336\",\"P56975\",\"Q02297\",\"Q8WWG1\",\"Q99075\"]", "gene_symbol": "[\"BTC\",\"DTR\",\"DTS\",\"EREG\",\"GGF\",\"GRB1\",\"HBEGF\",\"HEGFL\",\"HGL\",\"HRGA\",\"NDF\",\"NRG1\",\"NRG2\",\"NRG3\",\"NRG4\",\"NTAK\",\"PIK3CA\",\"PIK3R1\",\"SMDF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-12 signaling", "protein_name": "[{\"label\":\"Interleukin-12 receptor subunit beta-1\",\"id\":\"P42701\"},{\"label\":\"Interleukin-12 receptor subunit beta-2\",\"id\":\"Q99665\"},{\"label\":\"Interleukin-12 subunit alpha\",\"id\":\"P29459\"},{\"label\":\"Interleukin-12 subunit beta\",\"id\":\"P29460\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Protein disulfide-isomerase\",\"id\":\"P07237\"},{\"label\":\"Signal transducer and activator of transcription 4\",\"id\":\"Q14765\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Vesicle-associated membrane protein 7\",\"id\":\"P51809\"}]", "uniprot_id": "[\"O60674\",\"P07237\",\"P23458\",\"P29459\",\"P29460\",\"P29597\",\"P42701\",\"P51809\",\"Q14765\",\"Q99665\"]", "gene_symbol": 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5\",\"id\":\"Q8TDM6\"},{\"label\":\"Dystonin\",\"id\":\"Q03001\"},{\"label\":\"E3 ubiquitin-protein ligase SH3RF1\",\"id\":\"Q7Z6J0\"},{\"label\":\"Ephrin type-A receptor 2\",\"id\":\"P29317\"},{\"label\":\"Inactive tyrosine-protein kinase PEAK1\",\"id\":\"Q9H792\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 11\",\"id\":\"Q16584\"},{\"label\":\"Partitioning defective 6 homolog alpha\",\"id\":\"Q9NPB6\"},{\"label\":\"Partitioning defective 6 homolog beta\",\"id\":\"Q9BYG5\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP1\",\"id\":\"P46940\"},{\"label\":\"Rho GTPase-activating protein 12\",\"id\":\"Q8IWW6\"},{\"label\":\"Rho guanine nucleotide exchange factor 7\",\"id\":\"Q14155\"},{\"label\":\"Rho-related GTP-binding protein RhoV\",\"id\":\"Q96L33\"},{\"label\":\"SH2/SH3 adapter protein NCK1\",\"id\":\"P16333\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 4\",\"id\":\"O96013\"},{\"label\":\"Serine/threonine-protein kinase PAK 6\",\"id\":\"Q9NQU5\"},{\"label\":\"Spectrin alpha chain, non-erythrocytic 1\",\"id\":\"Q13813\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 1\",\"id\":\"Q01082\"},{\"label\":\"Thioredoxin-like protein 1\",\"id\":\"O43396\"},{\"label\":\"Tropomyosin alpha-3 chain\",\"id\":\"P06753\"},{\"label\":\"Tropomyosin alpha-4 chain\",\"id\":\"P67936\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 9X\",\"id\":\"Q93008\"},{\"label\":\"Unconventional myosin-IXa\",\"id\":\"B2RTY4\"},{\"label\":\"Vang-like protein 1\",\"id\":\"Q8TAA9\"},{\"label\":\"Zinc finger protein 512B\",\"id\":\"Q96KM6\"},{\"label\":\"tRNA (34-2'-O)-methyltransferase regulator WDR6\",\"id\":\"Q9NNW5\"}]", "uniprot_id": 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signaling", "protein_name": "[{\"label\":\"Beta-arrestin-1\",\"id\":\"P49407\"},{\"label\":\"Beta-arrestin-2\",\"id\":\"P32121\"},{\"label\":\"PDZ domain-containing protein GIPC1\",\"id\":\"O14908\"},{\"label\":\"TGF-beta receptor type-1\",\"id\":\"P36897\"},{\"label\":\"TGF-beta receptor type-2\",\"id\":\"P37173\"},{\"label\":\"Transforming growth factor beta receptor type 3\",\"id\":\"Q03167\"},{\"label\":\"Transforming growth factor beta-1 proprotein\",\"id\":\"P01137\"},{\"label\":\"Transforming growth factor beta-2 proprotein\",\"id\":\"P61812\"}]", "uniprot_id": "[\"O14908\",\"P01137\",\"P32121\",\"P36897\",\"P37173\",\"P49407\",\"P61812\",\"Q03167\"]", "gene_symbol": "[\"ALK5\",\"ARB2\",\"ARR1\",\"ARR2\",\"ARRB1\",\"ARRB2\",\"C19orf3\",\"GIPC\",\"GIPC1\",\"RGS19IP1\",\"SKR4\",\"TGFB\",\"TGFB1\",\"TGFB2\",\"TGFBR1\",\"TGFBR2\",\"TGFBR3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Sealing of the nuclear envelope (NE) by ESCRT-III", "protein_name": "[{\"label\":\"Charged multivesicular body protein 2a\",\"id\":\"O43633\"},{\"label\":\"Charged multivesicular body protein 2b\",\"id\":\"Q9UQN3\"},{\"label\":\"Charged multivesicular body protein 3\",\"id\":\"Q9Y3E7\"},{\"label\":\"Charged multivesicular body protein 4a\",\"id\":\"Q9BY43\"},{\"label\":\"Charged multivesicular body protein 4b\",\"id\":\"Q9H444\"},{\"label\":\"Charged multivesicular body protein 4c\",\"id\":\"Q96CF2\"},{\"label\":\"Charged multivesicular body protein 6\",\"id\":\"Q96FZ7\"},{\"label\":\"Charged multivesicular body protein 7\",\"id\":\"Q8WUX9\"},{\"label\":\"Coiled-coil and C2 domain-containing protein 1B\",\"id\":\"Q5T0F9\"},{\"label\":\"IST1 homolog\",\"id\":\"P53990\"},{\"label\":\"LEM domain-containing protein 2\",\"id\":\"Q8NC56\"},{\"label\":\"Putative tubulin-like protein alpha-4B\",\"id\":\"Q9H853\"},{\"label\":\"Spastin\",\"id\":\"Q9UBP0\"},{\"label\":\"Tubulin alpha chain-like 3\",\"id\":\"A6NHL2\"},{\"label\":\"Tubulin alpha-1A chain\",\"id\":\"Q71U36\"},{\"label\":\"Tubulin alpha-1B chain\",\"id\":\"P68363\"},{\"label\":\"Tubulin alpha-1C chain\",\"id\":\"Q9BQE3\"},{\"label\":\"Tubulin alpha-3C chain\",\"id\":\"P0DPH7\"},{\"label\":\"Tubulin alpha-3D chain\",\"id\":\"P0DPH8\"},{\"label\":\"Tubulin alpha-3E chain\",\"id\":\"Q6PEY2\"},{\"label\":\"Tubulin alpha-4A chain\",\"id\":\"P68366\"},{\"label\":\"Tubulin alpha-8 chain\",\"id\":\"Q9NY65\"},{\"label\":\"Tubulin beta 8B\",\"id\":\"A6NNZ2\"},{\"label\":\"Tubulin beta-1 chain\",\"id\":\"Q9H4B7\"},{\"label\":\"Tubulin beta-2A chain\",\"id\":\"Q13885\"},{\"label\":\"Tubulin beta-2B chain\",\"id\":\"Q9BVA1\"},{\"label\":\"Tubulin beta-3 chain\",\"id\":\"Q13509\"},{\"label\":\"Tubulin beta-4A chain\",\"id\":\"P04350\"},{\"label\":\"Tubulin beta-4B chain\",\"id\":\"P68371\"},{\"label\":\"Tubulin beta-6 chain\",\"id\":\"Q9BUF5\"},{\"label\":\"Tubulin beta-8 chain\",\"id\":\"Q3ZCM7\"},{\"label\":\"Vacuolar protein sorting-associated protein 4A\",\"id\":\"Q9UN37\"}]", "uniprot_id": "[\"A6NHL2\",\"A6NNZ2\",\"O43633\",\"P04350\",\"P0DPH7\",\"P0DPH8\",\"P53990\",\"P68363\",\"P68366\",\"P68371\",\"Q13509\",\"Q13885\",\"Q3ZCM7\",\"Q5T0F9\",\"Q6PEY2\",\"Q71U36\",\"Q8NC56\",\"Q8WUX9\",\"Q96CF2\",\"Q96FZ7\",\"Q9BQE3\",\"Q9BUF5\",\"Q9BVA1\",\"Q9BY43\",\"Q9H444\",\"Q9H4B7\",\"Q9H853\",\"Q9NY65\",\"Q9UBP0\",\"Q9UN37\",\"Q9UQN3\",\"Q9Y3E7\"]", "gene_symbol": 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6\",\"id\":\"Q8N139\"},{\"label\":\"ATP-binding cassette sub-family A member 9\",\"id\":\"Q8IUA7\"},{\"label\":\"ATP-binding cassette sub-family D member 1\",\"id\":\"P33897\"},{\"label\":\"ATP-binding cassette sub-family D member 2\",\"id\":\"Q9UBJ2\"},{\"label\":\"ATP-binding cassette sub-family D member 3\",\"id\":\"P28288\"},{\"label\":\"ATP-binding cassette sub-family G member 1\",\"id\":\"P45844\"},{\"label\":\"ATP-binding cassette sub-family G member 4\",\"id\":\"Q9H172\"},{\"label\":\"ATP-binding cassette sub-family G member 5\",\"id\":\"Q9H222\"},{\"label\":\"ATP-binding cassette sub-family G member 8\",\"id\":\"Q9H221\"},{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Cholesterol transporter ABCA5\",\"id\":\"Q8WWZ7\"},{\"label\":\"Glucosylceramide transporter ABCA12\",\"id\":\"Q86UK0\"},{\"label\":\"Peroxisomal biogenesis factor 19\",\"id\":\"P40855\"},{\"label\":\"Peroxisomal biogenesis factor 3\",\"id\":\"P56589\"},{\"label\":\"Phospholipid-transporting ATPase ABCA3\",\"id\":\"Q99758\"},{\"label\":\"Phospholipid-transporting ATPase ABCA7\",\"id\":\"Q8IZY2\"}]", "uniprot_id": "[\"P02647\",\"P28288\",\"P33897\",\"P40855\",\"P45844\",\"P56589\",\"Q86UK0\",\"Q8IUA7\",\"Q8IZY2\",\"Q8N139\",\"Q8WWZ4\",\"Q8WWZ7\",\"Q99758\",\"Q9BZC7\",\"Q9H172\",\"Q9H221\",\"Q9H222\",\"Q9UBJ2\"]", "gene_symbol": "[\"ABC12\",\"ABC2\",\"ABC3\",\"ABC8\",\"ABCA10\",\"ABCA12\",\"ABCA2\",\"ABCA3\",\"ABCA5\",\"ABCA6\",\"ABCA7\",\"ABCA9\",\"ABCD1\",\"ABCD2\",\"ABCD3\",\"ABCG1\",\"ABCG4\",\"ABCG5\",\"ABCG8\",\"ALD\",\"ALD1\",\"ALDL1\",\"ALDR\",\"ALDRP\",\"APOA1\",\"HK33\",\"KIAA1062\",\"KIAA1888\",\"PEX19\",\"PEX3\",\"PMP70\",\"PXF\",\"PXMP1\",\"WHITE2\",\"WHT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activated NTRK2 signals through FYN", "protein_name": "[{\"label\":\"BDNF/NT-3 growth factors receptor\",\"id\":\"Q16620\"},{\"label\":\"Brain-derived neurotrophic factor\",\"id\":\"P23560\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"}]", "uniprot_id": "[\"P12931\",\"P23560\",\"Q13224\",\"Q16620\"]", "gene_symbol": "[\"BDNF\",\"GRIN2B\",\"NMDAR2B\",\"NTRK2\",\"SRC\",\"SRC1\",\"TRKB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of IPs in the nucleus", "protein_name": "[{\"label\":\"Inositol hexakisphosphate kinase 1\",\"id\":\"Q92551\"},{\"label\":\"Inositol hexakisphosphate kinase 2\",\"id\":\"Q9UHH9\"},{\"label\":\"Inositol polyphosphate multikinase\",\"id\":\"Q8NFU5\"},{\"label\":\"Inositol-pentakisphosphate 2-kinase\",\"id\":\"Q9H8X2\"}]", "uniprot_id": "[\"Q8NFU5\",\"Q92551\",\"Q9H8X2\",\"Q9UHH9\"]", "gene_symbol": "[\"C9orf12\",\"IHPK1\",\"IHPK2\",\"IMPK\",\"IP6K1\",\"IP6K2\",\"IPMK\",\"IPPK\",\"KIAA0263\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "protein_name": "[{\"label\":\"Adrenocortical dysplasia protein homolog\",\"id\":\"Q96AP0\"},{\"label\":\"Endonuclease 8-like 1\",\"id\":\"Q96FI4\"},{\"label\":\"Endonuclease 8-like 2\",\"id\":\"Q969S2\"},{\"label\":\"Endonuclease 8-like 3\",\"id\":\"Q8TAT5\"},{\"label\":\"Endonuclease III-like protein 1\",\"id\":\"P78549\"},{\"label\":\"G/T mismatch-specific thymine DNA glycosylase\",\"id\":\"Q13569\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1t\",\"id\":\"Q16695\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Methyl-CpG-binding domain protein 4\",\"id\":\"O95243\"},{\"label\":\"N-glycosylase/DNA lyase\",\"id\":\"O15527\"},{\"label\":\"Protection of telomeres protein 1\",\"id\":\"Q9NUX5\"},{\"label\":\"Single-strand selective monofunctional uracil DNA glycosylase\",\"id\":\"Q53HV7\"},{\"label\":\"TERF1-interacting nuclear factor 2\",\"id\":\"Q9BSI4\"},{\"label\":\"Telomeric repeat-binding factor 1\",\"id\":\"P54274\"},{\"label\":\"Telomeric repeat-binding factor 2-interacting protein 1\",\"id\":\"Q9NYB0\"},{\"label\":\"Telomeric repeat-binding factor 2\",\"id\":\"Q15554\"}]", "uniprot_id": "[\"O15527\",\"O60814\",\"O95243\",\"P04908\",\"P06899\",\"P0C5Y9\",\"P16104\",\"P20671\",\"P23527\",\"P33778\",\"P54274\",\"P57053\",\"P58876\",\"P62805\",\"P62807\",\"P78549\",\"Q13569\",\"Q15554\",\"Q16695\",\"Q16777\",\"Q16778\",\"Q53HV7\",\"Q6FI13\",\"Q71UI9\",\"Q8N257\",\"Q8TAT5\",\"Q93077\",\"Q93079\",\"Q969S2\",\"Q96A08\",\"Q96AP0\",\"Q96FI4\",\"Q99877\",\"Q99878\",\"Q99879\",\"Q99880\",\"Q9BSI4\",\"Q9BTM1\",\"Q9NUX5\",\"Q9NYB0\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Antagonism of Activin by Follistatin", "protein_name": "[{\"label\":\"Follistatin-related protein 3\",\"id\":\"O95633\"},{\"label\":\"Follistatin\",\"id\":\"P19883\"},{\"label\":\"Inhibin beta A chain\",\"id\":\"P08476\"},{\"label\":\"Inhibin beta B chain\",\"id\":\"P09529\"}]", "uniprot_id": "[\"O95633\",\"P08476\",\"P09529\",\"P19883\"]", "gene_symbol": "[\"FLRG\",\"FST\",\"FSTL3\",\"INHBA\",\"INHBB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "snRNP Assembly", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Gem-associated protein 2\",\"id\":\"O14893\"},{\"label\":\"Gem-associated protein 4\",\"id\":\"P57678\"},{\"label\":\"Gem-associated protein 5\",\"id\":\"Q8TEQ6\"},{\"label\":\"Gem-associated protein 6\",\"id\":\"Q8WXD5\"},{\"label\":\"Gem-associated protein 7\",\"id\":\"Q9H840\"},{\"label\":\"Gem-associated protein 8\",\"id\":\"Q9NWZ8\"},{\"label\":\"Methylosome protein WDR77\",\"id\":\"Q9BQA1\"},{\"label\":\"Methylosome subunit pICln\",\"id\":\"P54105\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Phosphorylated adapter RNA export protein\",\"id\":\"Q9H814\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX20\",\"id\":\"Q9UHI6\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Protein arginine N-methyltransferase 5\",\"id\":\"O14744\"},{\"label\":\"Small nuclear ribonucleoprotein E\",\"id\":\"P62304\"},{\"label\":\"Small nuclear ribonucleoprotein F\",\"id\":\"P62306\"},{\"label\":\"Small nuclear ribonucleoprotein G\",\"id\":\"P62308\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D1\",\"id\":\"P62314\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D2\",\"id\":\"P62316\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D3\",\"id\":\"P62318\"},{\"label\":\"Small nuclear ribonucleoprotein-associated proteins B and B'\",\"id\":\"P14678\"},{\"label\":\"Snurportin-1\",\"id\":\"O95149\"},{\"label\":\"Survival motor neuron protein\",\"id\":\"Q16637\"},{\"label\":\"Trimethylguanosine synthase\",\"id\":\"Q96RS0\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": "[\"A8CG34\",\"O14744\",\"O14893\",\"O15504\",\"O75694\",\"O95149\",\"P12270\",\"P14678\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P52298\",\"P54105\",\"P55735\",\"P57678\",\"P57740\",\"P62304\",\"P62306\",\"P62308\",\"P62314\",\"P62316\",\"P62318\",\"P78406\",\"Q09161\",\"Q12769\",\"Q16637\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8N1F7\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8TEQ6\",\"Q8WUM0\",\"Q8WXD5\",\"Q92621\",\"Q96HA1\",\"Q96RS0\",\"Q99567\",\"Q9BQA1\",\"Q9BTX1\",\"Q9BW27\",\"Q9H814\",\"Q9H840\",\"Q9NRG9\",\"Q9NWZ8\",\"Q9UHI6\",\"Q9UKX7\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "SRP-dependent cotranslational protein targeting to membrane", "protein_name": "[{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit\",\"id\":\"P39656\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1\",\"id\":\"P04843\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2\",\"id\":\"P04844\"},{\"label\":\"Large ribosomal subunit protein P1\",\"id\":\"P05386\"},{\"label\":\"Large ribosomal subunit protein P2\",\"id\":\"P05387\"},{\"label\":\"Large ribosomal subunit protein eL13\",\"id\":\"P26373\"},{\"label\":\"Large ribosomal subunit protein eL14\",\"id\":\"P50914\"},{\"label\":\"Large ribosomal subunit protein eL15\",\"id\":\"P61313\"},{\"label\":\"Large ribosomal subunit protein eL18\",\"id\":\"Q07020\"},{\"label\":\"Large ribosomal subunit protein eL19\",\"id\":\"P84098\"},{\"label\":\"Large ribosomal subunit protein eL20\",\"id\":\"Q02543\"},{\"label\":\"Large ribosomal subunit protein eL21\",\"id\":\"P46778\"},{\"label\":\"Large ribosomal subunit protein eL22\",\"id\":\"P35268\"},{\"label\":\"Large ribosomal subunit protein eL24\",\"id\":\"P83731\"},{\"label\":\"Large ribosomal subunit protein eL27\",\"id\":\"P61353\"},{\"label\":\"Large ribosomal subunit protein eL28\",\"id\":\"P46779\"},{\"label\":\"Large ribosomal subunit protein eL29\",\"id\":\"P47914\"},{\"label\":\"Large ribosomal subunit protein eL30\",\"id\":\"P62888\"},{\"label\":\"Large ribosomal subunit protein eL31\",\"id\":\"P62899\"},{\"label\":\"Large ribosomal subunit protein eL32\",\"id\":\"P62910\"},{\"label\":\"Large ribosomal subunit protein eL33\",\"id\":\"P18077\"},{\"label\":\"Large ribosomal subunit protein eL34\",\"id\":\"P49207\"},{\"label\":\"Large ribosomal subunit protein eL36\",\"id\":\"Q9Y3U8\"},{\"label\":\"Large ribosomal subunit protein eL37\",\"id\":\"P61927\"},{\"label\":\"Large ribosomal subunit protein eL38\",\"id\":\"P63173\"},{\"label\":\"Large ribosomal subunit protein eL39\",\"id\":\"P62891\"},{\"label\":\"Large ribosomal subunit protein eL42\",\"id\":\"P83881\"},{\"label\":\"Large ribosomal subunit protein eL43\",\"id\":\"P61513\"},{\"label\":\"Large ribosomal subunit protein eL6\",\"id\":\"Q02878\"},{\"label\":\"Large ribosomal subunit protein eL8\",\"id\":\"P62424\"},{\"label\":\"Large ribosomal subunit protein uL10\",\"id\":\"P05388\"},{\"label\":\"Large ribosomal subunit protein uL11\",\"id\":\"P30050\"},{\"label\":\"Large ribosomal subunit protein uL13\",\"id\":\"P40429\"},{\"label\":\"Large ribosomal subunit protein uL14\",\"id\":\"P62829\"},{\"label\":\"Large ribosomal subunit protein uL15\",\"id\":\"P46776\"},{\"label\":\"Large ribosomal subunit protein uL16\",\"id\":\"P27635\"},{\"label\":\"Large ribosomal subunit protein uL18\",\"id\":\"P46777\"},{\"label\":\"Large ribosomal subunit protein uL1\",\"id\":\"P62906\"},{\"label\":\"Large ribosomal subunit protein uL22\",\"id\":\"P18621\"},{\"label\":\"Large ribosomal subunit protein uL23\",\"id\":\"P62750\"},{\"label\":\"Large ribosomal subunit protein uL24\",\"id\":\"P61254\"},{\"label\":\"Large ribosomal subunit protein uL29\",\"id\":\"P42766\"},{\"label\":\"Large ribosomal subunit protein uL2\",\"id\":\"P62917\"},{\"label\":\"Large ribosomal subunit protein uL30\",\"id\":\"P18124\"},{\"label\":\"Large ribosomal subunit protein uL3\",\"id\":\"P39023\"},{\"label\":\"Large ribosomal subunit protein uL4\",\"id\":\"P36578\"},{\"label\":\"Large ribosomal subunit protein uL5\",\"id\":\"P62913\"},{\"label\":\"Large ribosomal subunit protein uL6\",\"id\":\"P32969\"},{\"label\":\"Protein transport protein Sec61 subunit alpha isoform 1\",\"id\":\"P61619\"},{\"label\":\"Protein transport protein Sec61 subunit alpha isoform 2\",\"id\":\"Q9H9S3\"},{\"label\":\"Protein transport protein Sec61 subunit beta\",\"id\":\"P60468\"},{\"label\":\"Protein transport protein Sec61 subunit gamma\",\"id\":\"P60059\"},{\"label\":\"Ribosomal protein eL22-like\",\"id\":\"Q6P5R6\"},{\"label\":\"Ribosomal protein eL39-like 2\",\"id\":\"Q96EH5\"},{\"label\":\"Ribosomal protein eL42-like\",\"id\":\"Q969Q0\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Ribosomal protein uL16-like\",\"id\":\"Q96L21\"},{\"label\":\"Ribosomal protein uL24-like\",\"id\":\"Q9UNX3\"},{\"label\":\"Ribosomal protein uL3-like\",\"id\":\"Q92901\"},{\"label\":\"Signal peptidase complex catalytic subunit SEC11A\",\"id\":\"P67812\"},{\"label\":\"Signal peptidase complex catalytic subunit SEC11C\",\"id\":\"Q9BY50\"},{\"label\":\"Signal peptidase complex subunit 1\",\"id\":\"Q9Y6A9\"},{\"label\":\"Signal peptidase complex subunit 2\",\"id\":\"Q15005\"},{\"label\":\"Signal peptidase complex subunit 3\",\"id\":\"P61009\"},{\"label\":\"Signal recognition particle 14 kDa protein\",\"id\":\"P37108\"},{\"label\":\"Signal recognition particle 19 kDa 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muscle\",\"id\":\"P13807\"},{\"label\":\"Glycogenin-1\",\"id\":\"P46976\"},{\"label\":\"Glycogenin-2\",\"id\":\"O15488\"},{\"label\":\"Laforin\",\"id\":\"O95278\"},{\"label\":\"Phosphoglucomutase-1\",\"id\":\"P36871\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 3C\",\"id\":\"Q9UQK1\"},{\"label\":\"UTP--glucose-1-phosphate uridylyltransferase\",\"id\":\"Q16851\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O15488\",\"O95278\",\"P0CG47\",\"P0CG48\",\"P13807\",\"P36871\",\"P46976\",\"P54840\",\"P62979\",\"P62987\",\"Q04446\",\"Q16851\",\"Q6VVB1\",\"Q9UQK1\"]", "gene_symbol": 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mitochondrial\",\"id\":\"Q9Y2D0\"},{\"label\":\"Carbonic anhydrase 6\",\"id\":\"P23280\"},{\"label\":\"Carbonic anhydrase 7\",\"id\":\"P43166\"},{\"label\":\"Carbonic anhydrase 9\",\"id\":\"Q16790\"}]", "uniprot_id": "[\"O43570\",\"P00915\",\"P00918\",\"P07451\",\"P22748\",\"P23280\",\"P35218\",\"P43166\",\"Q16790\",\"Q8N1Q1\",\"Q9ULX7\",\"Q9Y2D0\"]", "gene_symbol": "[\"CA1\",\"CA12\",\"CA13\",\"CA14\",\"CA2\",\"CA3\",\"CA4\",\"CA5\",\"CA5A\",\"CA5B\",\"CA6\",\"CA7\",\"CA9\",\"G250\",\"MN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Hyaluronan uptake and degradation", "protein_name": "[{\"label\":\"Beta-glucuronidase\",\"id\":\"P08236\"},{\"label\":\"Beta-hexosaminidase subunit alpha\",\"id\":\"P06865\"},{\"label\":\"Beta-hexosaminidase subunit beta\",\"id\":\"P07686\"},{\"label\":\"CD44 antigen\",\"id\":\"P16070\"},{\"label\":\"Calcineurin B homologous protein 1\",\"id\":\"Q99653\"},{\"label\":\"Hyaluronan mediated motility 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ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Transcription factor JunB\",\"id\":\"P17275\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"},{\"label\":\"Twist-related protein 1\",\"id\":\"Q15672\"},{\"label\":\"Tyrosine-protein kinase ZAP-70\",\"id\":\"P43403\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"},{\"label\":\"Zinc finger C3HC-type protein 1\",\"id\":\"Q86WB0\"}]", "uniprot_id": "[\"P06400\",\"P06748\",\"P10144\",\"P14222\",\"P14635\",\"P17275\",\"P17676\",\"P26358\",\"P27361\",\"P28482\",\"P29350\",\"P40763\",\"P42229\",\"P43403\",\"P62753\",\"P62877\",\"P63208\",\"Q08050\",\"Q13547\",\"Q13616\",\"Q13651\",\"Q15306\",\"Q15672\",\"Q16548\",\"Q86WB0\",\"Q9H9G7\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9Y6W8\"]", "gene_symbol": 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subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-1\",\"id\":\"P63096\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-2\",\"id\":\"P04899\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-3\",\"id\":\"P08754\"},{\"label\":\"Guanine nucleotide-binding protein G(t) subunit alpha-3\",\"id\":\"A8MTJ3\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"P2Y purinoceptor 12\",\"id\":\"Q9H244\"}]", "uniprot_id": "[\"A8MTJ3\",\"O14610\",\"O14775\",\"O60262\",\"P04899\",\"P08754\",\"P16520\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63096\",\"P63211\",\"P63215\",\"P63218\",\"Q9H244\",\"Q9HAV0\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": "[\"GNAI1\",\"GNAI2\",\"GNAI2B\",\"GNAI3\",\"GNAT3\",\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNB5\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT1\",\"GNGT10\",\"GNGT11\",\"GNGT2\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT8\",\"GNGT9\",\"HORK3\",\"P2RY12\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by FGFR2 in disease", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 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subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O15520\",\"O43320\",\"O76093\",\"P01111\",\"P01112\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11487\",\"P19174\",\"P21781\",\"P21802\",\"P27986\",\"P31371\",\"P42336\",\"Q07889\",\"Q13480\",\"Q8WU20\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", "gene_symbol": "[\"BEK\",\"FGF1\",\"FGF10\",\"FGF16\",\"FGF18\",\"FGF2\",\"FGF20\",\"FGF22\",\"FGF23\",\"FGF3\",\"FGF4\",\"FGF6\",\"FGF7\",\"FGF9\",\"FGFA\",\"FGFB\",\"FGFR2\",\"FRS2\",\"GAB1\",\"GRB1\",\"HRAS\",\"HRAS1\",\"HST\",\"HST2\",\"HSTF1\",\"HSTF2\",\"HYPF\",\"INT2\",\"KGF\",\"KGFR\",\"KS3\",\"KSAM\",\"NRAS\",\"PIK3CA\",\"PIK3R1\",\"PLC1\",\"PLCG1\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective CBLIF causes IFD", "protein_name": "[{\"label\":\"Cobalamin binding intrinsic factor\",\"id\":\"P27352\"}]", "uniprot_id": "[\"P27352\"]", "gene_symbol": "[\"CBLIF\",\"GIF\",\"IFMH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HATs acetylate histones", "protein_name": "[{\"label\":\"Actin, cytoplasmic 1\",\"id\":\"P60709\"},{\"label\":\"Actin-like protein 6A\",\"id\":\"O96019\"},{\"label\":\"Ataxin-7-like protein 3\",\"id\":\"Q14CW9\"},{\"label\":\"Ataxin-7\",\"id\":\"O15265\"},{\"label\":\"Bromodomain and PHD finger-containing protein 3\",\"id\":\"Q9ULD4\"},{\"label\":\"Bromodomain-containing protein 1\",\"id\":\"O95696\"},{\"label\":\"Bromodomain-containing protein 8\",\"id\":\"Q9H0E9\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Chromatin modification-related protein MEAF6\",\"id\":\"Q9HAF1\"},{\"label\":\"Circadian locomoter output cycles protein kaput\",\"id\":\"O15516\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-2\",\"id\":\"P15336\"},{\"label\":\"Cysteine-rich protein 2-binding 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"gtc_id": "[\"\"]" }, { "pathway_label": "Formation of definitive endoderm", "protein_name": "[{\"label\":\"C-X-C chemokine receptor type 4\",\"id\":\"P61073\"},{\"label\":\"Cadherin-1\",\"id\":\"P12830\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Eomesodermin homolog\",\"id\":\"O95936\"},{\"label\":\"Hepatocyte nuclear factor 3-beta\",\"id\":\"Q9Y261\"},{\"label\":\"Homeobox protein MIXL1\",\"id\":\"Q9H2W2\"},{\"label\":\"Homeobox protein goosecoid\",\"id\":\"P56915\"},{\"label\":\"Mothers against decapentaplegic homolog 2\",\"id\":\"Q15796\"},{\"label\":\"Mothers against decapentaplegic homolog 3\",\"id\":\"P84022\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"T-box transcription factor T\",\"id\":\"O15178\"},{\"label\":\"Transcription factor 7-like 2\",\"id\":\"Q9NQB0\"},{\"label\":\"Transcription factor GATA-4\",\"id\":\"P43694\"},{\"label\":\"Transcription factor GATA-6\",\"id\":\"Q92908\"},{\"label\":\"Transcription factor SOX-17\",\"id\":\"Q9H6I2\"}]", "uniprot_id": "[\"O15178\",\"O95936\",\"P12830\",\"P35222\",\"P43694\",\"P56915\",\"P61073\",\"P84022\",\"Q13485\",\"Q15796\",\"Q92908\",\"Q9H2W2\",\"Q9H6I2\",\"Q9NQB0\",\"Q9Y261\"]", "gene_symbol": "[\"CDH1\",\"CDHE\",\"CTNNB\",\"CTNNB1\",\"CXCR4\",\"DPC4\",\"EOMES\",\"FOXA2\",\"GATA4\",\"GATA6\",\"GSC\",\"HNF3B\",\"MADH2\",\"MADH3\",\"MADH4\",\"MADR2\",\"MIXL\",\"MIXL1\",\"SMAD2\",\"SMAD3\",\"SMAD4\",\"SOX17\",\"T\",\"TBR2\",\"TBXT\",\"TCF3B\",\"TCF4\",\"TCF7L2\",\"UVO\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcription-Coupled Nucleotide Excision Repair (TC-NER)", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cullin-4A\",\"id\":\"Q13619\"},{\"label\":\"Cullin-4B\",\"id\":\"Q13620\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA damage-binding protein 1\",\"id\":\"Q16531\"},{\"label\":\"DNA excision repair protein ERCC-6\",\"id\":\"Q03468\"},{\"label\":\"DNA excision repair protein ERCC-8\",\"id\":\"Q13216\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase E\",\"id\":\"Q9UNP9\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Pre-mRNA-processing factor 19\",\"id\":\"Q9UMS4\"},{\"label\":\"Pre-mRNA-splicing factor ISY1 homolog\",\"id\":\"Q9ULR0\"},{\"label\":\"Pre-mRNA-splicing factor SYF1\",\"id\":\"Q9HCS7\"},{\"label\":\"RNA helicase aquarius\",\"id\":\"O60306\"},{\"label\":\"RNA polymerase II elongation factor ELL\",\"id\":\"P55199\"},{\"label\":\"Transcription elongation factor A protein 1\",\"id\":\"P23193\"},{\"label\":\"UV-stimulated scaffold protein A\",\"id\":\"Q2YD98\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 7\",\"id\":\"Q93009\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Zinc finger protein 830\",\"id\":\"Q96NB3\"}]", "uniprot_id": 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surface", "protein_name": "[{\"label\":\"Ficolin-1\",\"id\":\"O00602\"},{\"label\":\"Ficolin-2\",\"id\":\"Q15485\"},{\"label\":\"Ficolin-3\",\"id\":\"O75636\"},{\"label\":\"Mannan-binding lectin serine protease 1\",\"id\":\"P48740\"}]", "uniprot_id": "[\"O00602\",\"O75636\",\"P48740\",\"Q15485\"]", "gene_symbol": "[\"CRARF\",\"CRARF1\",\"FCN1\",\"FCN2\",\"FCN3\",\"FCNH\",\"FCNL\",\"FCNM\",\"HAKA1\",\"MASP1\",\"PRSS5\"]", "gtc_id": "[\"G49108TO\",\"G57321FI\"]" }, { "pathway_label": "Signaling by Leptin", "protein_name": "[{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Leptin\",\"id\":\"P41159\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Suppressor of cytokine signaling 3\",\"id\":\"O14543\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O14543\",\"O60674\",\"P35568\",\"P40763\",\"P41159\",\"P42229\",\"P51692\",\"Q06124\",\"Q9Y4H2\"]", "gene_symbol": "[\"APRF\",\"CIS3\",\"IRS1\",\"IRS2\",\"JAK2\",\"LEP\",\"OB\",\"OBS\",\"PTP2C\",\"PTPN11\",\"SHPTP2\",\"SOCS3\",\"SSI3\",\"STAT3\",\"STAT5\",\"STAT5A\",\"STAT5B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Entry of Influenza Virion into Host Cell via Endocytosis", "protein_name": "[{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Clathrin light chain A\",\"id\":\"P09496\"},{\"label\":\"Hemagglutinin\",\"id\":\"P03452\"},{\"label\":\"Matrix protein 1\",\"id\":\"P03485\"},{\"label\":\"Matrix protein 2\",\"id\":\"P06821\"},{\"label\":\"Neuraminidase\",\"id\":\"P03468\"},{\"label\":\"Nuclear export protein\",\"id\":\"P03508\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"}]", "uniprot_id": "[\"P03428\",\"P03431\",\"P03433\",\"P03452\",\"P03466\",\"P03468\",\"P03485\",\"P03508\",\"P06821\",\"P09496\",\"Q00610\"]", "gene_symbol": "[\"CLH17\",\"CLTA\",\"CLTC\",\"CLTCL2\",\"HA\",\"KIAA0034\",\"M\",\"NA\",\"NP\",\"NS\",\"PA\",\"PB1\",\"PB2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RHOA GTPase cycle", "protein_name": "[{\"label\":\"A-kinase anchor protein 13\",\"id\":\"Q12802\"},{\"label\":\"ATP-binding cassette sub-family D member 3\",\"id\":\"P28288\"},{\"label\":\"Actin, alpha cardiac muscle 1\",\"id\":\"P68032\"},{\"label\":\"Active breakpoint cluster region-related protein\",\"id\":\"Q12979\"},{\"label\":\"Acyl-CoA-binding domain-containing protein 5\",\"id\":\"Q5T8D3\"},{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Anillin\",\"id\":\"Q9NQW6\"},{\"label\":\"Ankyrin repeat domain-containing protein SOWAHC\",\"id\":\"Q53LP3\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1\",\"id\":\"Q96P48\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2\",\"id\":\"Q8WZ64\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3\",\"id\":\"Q8WWN8\"},{\"label\":\"B-cell receptor-associated protein 31\",\"id\":\"P51572\"},{\"label\":\"Breakpoint cluster region protein\",\"id\":\"P11274\"},{\"label\":\"Caveolae-associated protein 1\",\"id\":\"Q6NZI2\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Cell surface glycoprotein MUC18\",\"id\":\"P43121\"},{\"label\":\"Citron Rho-interacting kinase\",\"id\":\"O14578\"},{\"label\":\"Coiled-coil domain-containing protein 115\",\"id\":\"Q96NT0\"},{\"label\":\"Complement component 1 Q subcomponent-binding protein, mitochondrial\",\"id\":\"Q07021\"},{\"label\":\"DDRGK domain-containing protein 1\",\"id\":\"Q96HY6\"},{\"label\":\"DEP domain-containing protein 1B\",\"id\":\"Q8WUY9\"},{\"label\":\"Dedicator of cytokinesis protein 2\",\"id\":\"Q92608\"},{\"label\":\"Delta(14)-sterol reductase LBR\",\"id\":\"Q14739\"},{\"label\":\"Differentially expressed in FDCP 6 homolog\",\"id\":\"Q9H4E7\"},{\"label\":\"Disheveled-associated activator of morphogenesis 1\",\"id\":\"Q9Y4D1\"},{\"label\":\"ER membrane protein complex subunit 3\",\"id\":\"Q9P0I2\"},{\"label\":\"Ephexin-1\",\"id\":\"Q8N5V2\"},{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"FAS-associated factor 2\",\"id\":\"Q96CS3\"},{\"label\":\"FERM, ARHGEF and pleckstrin domain-containing protein 1\",\"id\":\"Q9Y4F1\"},{\"label\":\"Flotillin-1\",\"id\":\"O75955\"},{\"label\":\"Flotillin-2\",\"id\":\"Q14254\"},{\"label\":\"Formin-like protein 3\",\"id\":\"Q8IVF7\"},{\"label\":\"GEM-interacting protein\",\"id\":\"Q9P107\"},{\"label\":\"Guanine nucleotide exchange factor DBS\",\"id\":\"O15068\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Guanine nucleotide exchange factor VAV3\",\"id\":\"Q9UKW4\"},{\"label\":\"Heme oxygenase 2\",\"id\":\"P30519\"},{\"label\":\"Inactive Rho GTPase-activating protein 11B\",\"id\":\"Q3KRB8\"},{\"label\":\"Junction plakoglobin\",\"id\":\"P14923\"},{\"label\":\"Kalirin\",\"id\":\"O60229\"},{\"label\":\"Kinectin\",\"id\":\"Q86UP2\"},{\"label\":\"Lamina-associated polypeptide 2, isoforms beta/gamma\",\"id\":\"P42167\"},{\"label\":\"Macoilin\",\"id\":\"Q8N5G2\"},{\"label\":\"Membrane-associated progesterone receptor component 2\",\"id\":\"O15173\"},{\"label\":\"Neuroepithelial cell-transforming gene 1 protein\",\"id\":\"Q7Z628\"},{\"label\":\"Obscurin\",\"id\":\"Q5VST9\"},{\"label\":\"Oligophrenin-1\",\"id\":\"O60890\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein\",\"id\":\"Q70Z35\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phospholipase D1\",\"id\":\"Q13393\"},{\"label\":\"Pleckstrin homology domain-containing family G member 3\",\"id\":\"A1L390\"},{\"label\":\"Pleckstrin homology domain-containing family G member 5\",\"id\":\"O94827\"},{\"label\":\"Pleckstrin homology domain-containing family G member 6\",\"id\":\"Q3KR16\"},{\"label\":\"Protein ECT2\",\"id\":\"Q9H8V3\"},{\"label\":\"Protein ERGIC-53\",\"id\":\"P49257\"},{\"label\":\"Protein FAM13A\",\"id\":\"O94988\"},{\"label\":\"Protein diaphanous homolog 1\",\"id\":\"O60610\"},{\"label\":\"Protein diaphanous homolog 3\",\"id\":\"Q9NSV4\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Proto-oncogene 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"gtc_id": "[\"\"]" }, { "pathway_label": "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs", "protein_name": "[{\"label\":\"Histone RNA hairpin-binding protein\",\"id\":\"Q14493\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Small nuclear ribonucleoprotein E\",\"id\":\"P62304\"},{\"label\":\"Small nuclear ribonucleoprotein F\",\"id\":\"P62306\"},{\"label\":\"Small nuclear ribonucleoprotein G\",\"id\":\"P62308\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D3\",\"id\":\"P62318\"},{\"label\":\"Small nuclear ribonucleoprotein-associated proteins B and B'\",\"id\":\"P14678\"},{\"label\":\"U7 snRNA-associated Sm-like protein LSm10\",\"id\":\"Q969L4\"},{\"label\":\"U7 snRNA-associated Sm-like protein LSm11\",\"id\":\"P83369\"},{\"label\":\"Zinc finger protein 473\",\"id\":\"Q8WTR7\"}]", "uniprot_id": 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1\",\"id\":\"Q01082\"},{\"label\":\"Stereocilin\",\"id\":\"Q7RTU9\"},{\"label\":\"Taperin\",\"id\":\"Q4KMQ1\"},{\"label\":\"Transmembrane channel-like protein 1\",\"id\":\"Q8TDI8\"},{\"label\":\"Transmembrane channel-like protein 2\",\"id\":\"Q8TDI7\"},{\"label\":\"Transmembrane inner ear expressed protein\",\"id\":\"Q8NEW7\"},{\"label\":\"Twinfilin-1\",\"id\":\"Q12792\"},{\"label\":\"Twinfilin-2\",\"id\":\"Q6IBS0\"},{\"label\":\"Unconventional myosin-Ic\",\"id\":\"O00159\"},{\"label\":\"Unconventional myosin-VIIa\",\"id\":\"Q13402\"},{\"label\":\"Unconventional myosin-XV\",\"id\":\"Q9UKN7\"},{\"label\":\"Whirlin\",\"id\":\"Q9P202\"},{\"label\":\"Xin actin-binding repeat-containing protein 2\",\"id\":\"A4UGR9\"},{\"label\":\"pre-mRNA splicing regulator USH1G\",\"id\":\"Q495M9\"}]", "uniprot_id": 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nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas\",\"id\":\"Q5JWF2\"},{\"label\":\"Guanine nucleotide-binding protein G(s) subunit alpha isoforms short\",\"id\":\"P63092\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Prostacyclin receptor\",\"id\":\"P43119\"}]", "uniprot_id": 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2-beta-N-acetylglucosaminyltransferase\",\"id\":\"P26572\"},{\"label\":\"Calnexin\",\"id\":\"P27824\"},{\"label\":\"Glucosidase 2 subunit beta\",\"id\":\"P14314\"},{\"label\":\"Mannosyl-oligosaccharide glucosidase\",\"id\":\"Q13724\"},{\"label\":\"Neutral alpha-glucosidase AB\",\"id\":\"Q14697\"},{\"label\":\"Spike glycoprotein\",\"id\":\"P59594\"}]", "uniprot_id": "[\"P14314\",\"P26572\",\"P27824\",\"P59594\",\"Q13724\",\"Q14697\"]", "gene_symbol": "[\"CANX\",\"G19P1\",\"G2AN\",\"GANAB\",\"GCS1\",\"GGNT1\",\"GLCT1\",\"GLYT1\",\"KIAA0088\",\"MGAT\",\"MGAT1\",\"MOGS\",\"PRKCSH\",\"S\"]", "gtc_id": "[\"G71142DF\"]" }, { "pathway_label": "lestaurtinib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "APC/C:Cdc20 mediated degradation of Cyclin B", "protein_name": 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homolog\",\"id\":\"P30260\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 C\",\"id\":\"O00762\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 E1\",\"id\":\"P51965\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 S\",\"id\":\"Q16763\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00762\",\"P06493\",\"P0CG47\",\"P0CG48\",\"P14635\",\"P30260\",\"P51668\",\"P51965\",\"P60006\",\"P62979\",\"P62987\",\"Q12834\",\"Q13042\",\"Q16763\",\"Q8NHZ8\",\"Q96DE5\",\"Q9H1A4\",\"Q9NYG5\",\"Q9UJX2\",\"Q9UJX3\",\"Q9UJX4\",\"Q9UJX5\",\"Q9UJX6\",\"Q9UM13\"]", "gene_symbol": 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1\",\"id\":\"Q5SW96\"},{\"label\":\"Low-density lipoprotein receptor-related protein 2\",\"id\":\"P98164\"},{\"label\":\"Lysosomal cobalamin transport escort protein LMBD1\",\"id\":\"Q9NUN5\"},{\"label\":\"Lysosomal cobalamin transporter ABCD4\",\"id\":\"O14678\"},{\"label\":\"Multidrug resistance-associated protein 1\",\"id\":\"P33527\"},{\"label\":\"Transcobalamin-1\",\"id\":\"P20061\"},{\"label\":\"Transcobalamin-2\",\"id\":\"P20062\"}]", "uniprot_id": "[\"O14678\",\"P20061\",\"P20062\",\"P33527\",\"P98164\",\"Q5SW96\",\"Q9NPF0\",\"Q9NUN5\"]", "gene_symbol": "[\"8D6A\",\"ABCC1\",\"ABCD4\",\"ARH\",\"C6orf209\",\"CD320\",\"LDLRAP1\",\"LMBRD1\",\"LRP2\",\"MRP\",\"MRP1\",\"NESI\",\"PXMP1L\",\"TC1\",\"TC2\",\"TCN1\",\"TCN2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Beta oxidation of palmitoyl-CoA to myristoyl-CoA", "protein_name": "[{\"label\":\"Trifunctional enzyme subunit alpha, mitochondrial\",\"id\":\"P40939\"},{\"label\":\"Trifunctional enzyme subunit beta, mitochondrial\",\"id\":\"P55084\"},{\"label\":\"Very long-chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P49748\"}]", "uniprot_id": "[\"P40939\",\"P49748\",\"P55084\"]", "gene_symbol": "[\"ACADVL\",\"HADH\",\"HADHA\",\"HADHB\",\"VLCAD\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Resistance of ERBB2 KD mutants to afatinib", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P04626\",\"P07900\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Phase 1 - inactivation of fast Na+ channels", "protein_name": "[{\"label\":\"A-type potassium channel modulatory protein KCNIP1\",\"id\":\"Q9NZI2\"},{\"label\":\"A-type potassium channel modulatory protein KCNIP2\",\"id\":\"Q9NS61\"},{\"label\":\"A-type voltage-gated potassium channel KCND1\",\"id\":\"Q9NSA2\"},{\"label\":\"A-type voltage-gated potassium channel KCND2\",\"id\":\"Q9NZV8\"},{\"label\":\"A-type voltage-gated potassium channel KCND3\",\"id\":\"Q9UK17\"},{\"label\":\"Calsenilin\",\"id\":\"Q9Y2W7\"},{\"label\":\"Kv channel-interacting protein 4\",\"id\":\"Q6PIL6\"}]", "uniprot_id": "[\"Q6PIL6\",\"Q9NS61\",\"Q9NSA2\",\"Q9NZI2\",\"Q9NZV8\",\"Q9UK17\",\"Q9Y2W7\"]", "gene_symbol": "[\"CALP\",\"CSEN\",\"DREAM\",\"KCHIP1\",\"KCHIP2\",\"KCHIP3\",\"KCHIP4\",\"KCND1\",\"KCND2\",\"KCND3\",\"KCNIP1\",\"KCNIP2\",\"KCNIP3\",\"KCNIP4\",\"KIAA1044\",\"VABP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "N-glycan trimming in the ER and Calnexin/Calreticulin cycle", "protein_name": "[{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"Cytosolic endo-beta-N-acetylglucosaminidase\",\"id\":\"Q8NFI3\"},{\"label\":\"Derlin-1\",\"id\":\"Q9BUN8\"},{\"label\":\"E3 ubiquitin-protein ligase AMFR\",\"id\":\"Q9UKV5\"},{\"label\":\"Glucosidase 2 subunit beta\",\"id\":\"P14314\"},{\"label\":\"Malectin\",\"id\":\"Q14165\"},{\"label\":\"Mannosyl-oligosaccharide glucosidase\",\"id\":\"Q13724\"},{\"label\":\"Neutral alpha-glucosidase AB\",\"id\":\"Q14697\"},{\"label\":\"Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase\",\"id\":\"Q96IV0\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Transitional endoplasmic reticulum ATPase\",\"id\":\"P55072\"},{\"label\":\"UBX domain-containing protein 1\",\"id\":\"Q04323\"},{\"label\":\"UV excision repair protein RAD23 homolog B\",\"id\":\"P54727\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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"Josephin domain DUBs", "protein_name": "[{\"label\":\"Ataxin-3-like protein\",\"id\":\"Q9H3M9\"},{\"label\":\"Ataxin-3\",\"id\":\"P54252\"},{\"label\":\"E3 ubiquitin-protein ligase parkin\",\"id\":\"O60260\"},{\"label\":\"Josephin-1\",\"id\":\"Q15040\"},{\"label\":\"Josephin-2\",\"id\":\"Q8TAC2\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Transitional endoplasmic reticulum ATPase\",\"id\":\"P55072\"},{\"label\":\"UV excision repair protein RAD23 homolog A\",\"id\":\"P54725\"},{\"label\":\"UV excision repair protein RAD23 homolog B\",\"id\":\"P54727\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O60260\",\"P0CG47\",\"P0CG48\",\"P54252\",\"P54725\",\"P54727\",\"P55072\",\"P62979\",\"P62987\",\"Q15040\",\"Q8TAC2\",\"Q9H3M9\"]", "gene_symbol": 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RBBP4\",\"id\":\"Q09028\"},{\"label\":\"M-phase inducer phosphatase 1\",\"id\":\"P30304\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Protein lin-37 homolog\",\"id\":\"Q96GY3\"},{\"label\":\"Protein lin-52 homolog\",\"id\":\"Q52LA3\"},{\"label\":\"Protein lin-54 homolog\",\"id\":\"Q6MZP7\"},{\"label\":\"Protein lin-9 homolog\",\"id\":\"Q5TKA1\"},{\"label\":\"Protein max\",\"id\":\"P61244\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Retinoblastoma-like protein 2\",\"id\":\"Q08999\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Transcription factor E2F4\",\"id\":\"Q16254\"},{\"label\":\"Transcription factor E2F5\",\"id\":\"Q15329\"},{\"label\":\"Wee1-like protein kinase\",\"id\":\"P30291\"}]", "uniprot_id": "[\"O96020\",\"P01106\",\"P06400\",\"P24864\",\"P24941\",\"P30291\",\"P30304\",\"P31749\",\"P31751\",\"P38936\",\"P46527\",\"P50613\",\"P51946\",\"P51948\",\"P61244\",\"Q01094\",\"Q08999\",\"Q09028\",\"Q14186\",\"Q14188\",\"Q15329\",\"Q16254\",\"Q52LA3\",\"Q5TKA1\",\"Q6MZP7\",\"Q8TDN4\",\"Q96GY3\",\"Q9Y243\"]", "gene_symbol": 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3\",\"id\":\"Q5SZD4\"},{\"label\":\"Glycine N-acyltransferase\",\"id\":\"Q6IB77\"}]", "uniprot_id": "[\"P0C7M7\",\"Q08AH3\",\"Q5SZD4\",\"Q68CK6\",\"Q6IB77\",\"Q6NUN0\",\"Q8WU03\",\"Q969I3\"]", "gene_symbol": "[\"ACGNAT\",\"ACSM2\",\"ACSM2A\",\"ACSM2B\",\"ACSM4\",\"ACSM5\",\"C6orf140\",\"CAT\",\"GAT\",\"GLYAT\",\"GLYATL1\",\"GLYATL2\",\"GLYATL3\",\"GNAT\",\"MACS2\",\"MACS3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX2 regulates bone development", "protein_name": "[{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"Mothers against decapentaplegic homolog 1\",\"id\":\"Q15797\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"Mothers against decapentaplegic homolog 6\",\"id\":\"O43541\"},{\"label\":\"RNA-binding protein 14\",\"id\":\"Q96PK6\"}]", "uniprot_id": "[\"O43541\",\"Q13485\",\"Q13951\",\"Q15797\",\"Q96PK6\"]", "gene_symbol": 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isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O15169\",\"P25054\",\"P30153\",\"P30154\",\"P48729\",\"P49841\",\"P62714\",\"P67775\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\"]", "gene_symbol": "[\"AMER1\",\"APC\",\"AXIN\",\"AXIN1\",\"CSNK1A1\",\"DP2.5\",\"FAM123B\",\"GSK3B\",\"KIAA0044\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"WTX\"]", "gtc_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "NOSTRIN mediated eNOS trafficking", "protein_name": "[{\"label\":\"Actin nucleation-promoting factor WASL\",\"id\":\"O00401\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Dynamin-2\",\"id\":\"P50570\"},{\"label\":\"Nitric oxide synthase 3\",\"id\":\"P29474\"},{\"label\":\"Nostrin\",\"id\":\"Q8IVI9\"}]", "uniprot_id": "[\"O00401\",\"P29474\",\"P50570\",\"Q03135\",\"Q8IVI9\"]", "gene_symbol": "[\"CAV\",\"CAV1\",\"DNM2\",\"DYN2\",\"NOS3\",\"NOSTRIN\",\"WASL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RAF activation", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"BRCA1-associated protein\",\"id\":\"Q7Z569\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 1\",\"id\":\"Q02750\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 2\",\"id\":\"P36507\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Kinase suppressor of Ras 1\",\"id\":\"Q8IVT5\"},{\"label\":\"Leucine-rich repeat protein SHOC-2\",\"id\":\"Q9UQ13\"},{\"label\":\"MAP/microtubule affinity-regulating kinase 3\",\"id\":\"P27448\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 11\",\"id\":\"Q16584\"},{\"label\":\"Prohibitin 1\",\"id\":\"P35232\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"Ras-related protein M-Ras\",\"id\":\"O14807\"},{\"label\":\"Serine/threonine-protein kinase A-Raf\",\"id\":\"P10398\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-beta catalytic subunit\",\"id\":\"P62140\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-gamma catalytic subunit\",\"id\":\"P36873\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"}]", "uniprot_id": "[\"O14807\",\"O60674\",\"P01111\",\"P01112\",\"P04049\",\"P0DP23\",\"P10398\",\"P12931\",\"P15056\",\"P27448\",\"P30153\",\"P30154\",\"P31946\",\"P35232\",\"P36507\",\"P36873\",\"P62140\",\"P62714\",\"P67775\",\"Q02750\",\"Q13362\",\"Q13554\",\"Q13555\",\"Q13557\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q16584\",\"Q7Z569\",\"Q8IVT5\",\"Q9UQ13\",\"Q9UQM7\"]", "gene_symbol": 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eta\",\"id\":\"Q04917\"},{\"label\":\"14-3-3 protein gamma\",\"id\":\"P61981\"},{\"label\":\"14-3-3 protein sigma\",\"id\":\"P31947\"},{\"label\":\"14-3-3 protein theta\",\"id\":\"P27348\"},{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-2\",\"id\":\"P54646\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-1\",\"id\":\"Q9Y478\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-2\",\"id\":\"O43741\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-1\",\"id\":\"P54619\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-2\",\"id\":\"Q9UGJ0\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-3\",\"id\":\"Q9UGI9\"},{\"label\":\"C2 domain-containing protein 5\",\"id\":\"Q86YS7\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Exocyst complex component 1\",\"id\":\"Q9NV70\"},{\"label\":\"Exocyst complex component 2\",\"id\":\"Q96KP1\"},{\"label\":\"Exocyst complex component 3\",\"id\":\"O60645\"},{\"label\":\"Exocyst complex component 4\",\"id\":\"Q96A65\"},{\"label\":\"Exocyst complex component 5\",\"id\":\"O00471\"},{\"label\":\"Exocyst complex component 6\",\"id\":\"Q8TAG9\"},{\"label\":\"Exocyst complex component 7\",\"id\":\"Q9UPT5\"},{\"label\":\"Exocyst complex component 8\",\"id\":\"Q8IYI6\"},{\"label\":\"Kinesin-associated protein 3\",\"id\":\"Q92845\"},{\"label\":\"Kinesin-like protein KIF3A\",\"id\":\"Q9Y496\"},{\"label\":\"Kinesin-like protein KIF3B\",\"id\":\"O15066\"},{\"label\":\"Leucyl-cystinyl aminopeptidase\",\"id\":\"Q9UIQ6\"},{\"label\":\"Myosin-9\",\"id\":\"P35579\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"Ral GTPase-activating protein subunit alpha-2\",\"id\":\"Q2PPJ7\"},{\"label\":\"Ral GTPase-activating protein subunit beta\",\"id\":\"Q86X10\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Ras-related protein Rab-10\",\"id\":\"P61026\"},{\"label\":\"Ras-related protein Rab-11A\",\"id\":\"P62491\"},{\"label\":\"Ras-related protein Rab-13\",\"id\":\"P51153\"},{\"label\":\"Ras-related protein Rab-14\",\"id\":\"P61106\"},{\"label\":\"Ras-related protein Rab-4A\",\"id\":\"P20338\"},{\"label\":\"Ras-related protein Rab-8A\",\"id\":\"P61006\"},{\"label\":\"Ras-related protein Ral-A\",\"id\":\"P11233\"},{\"label\":\"Rho-related GTP-binding protein RhoQ\",\"id\":\"P17081\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 4\",\"id\":\"P14672\"},{\"label\":\"Synaptosomal-associated protein 23\",\"id\":\"O00161\"},{\"label\":\"Syntaxin-4\",\"id\":\"Q12846\"},{\"label\":\"Syntaxin-binding protein 3\",\"id\":\"O00186\"},{\"label\":\"TBC1 domain family member 1\",\"id\":\"Q86TI0\"},{\"label\":\"TBC1 domain family member 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"gtc_id": "[\"\"]" }, { "pathway_label": "Glutamate and glutamine metabolism", "protein_name": "[{\"label\":\"Aspartate aminotransferase, mitochondrial\",\"id\":\"P00505\"},{\"label\":\"Beta-citrylglutamate synthase B\",\"id\":\"Q9ULI2\"},{\"label\":\"Glutamate dehydrogenase 1, mitochondrial\",\"id\":\"P00367\"},{\"label\":\"Glutamate dehydrogenase 2, mitochondrial\",\"id\":\"P49448\"},{\"label\":\"Glutaminase kidney isoform, mitochondrial\",\"id\":\"O94925\"},{\"label\":\"Glutaminase liver isoform, mitochondrial\",\"id\":\"Q9UI32\"},{\"label\":\"Glutamine synthetase\",\"id\":\"P15104\"},{\"label\":\"Kynurenine--oxoglutarate transaminase 1\",\"id\":\"Q16773\"},{\"label\":\"N-acetylaspartylglutamate synthase A\",\"id\":\"Q8IXN7\"},{\"label\":\"Ornithine aminotransferase, mitochondrial\",\"id\":\"P04181\"},{\"label\":\"Pyrroline-5-carboxylate reductase 1, mitochondrial\",\"id\":\"P32322\"},{\"label\":\"Pyrroline-5-carboxylate reductase 2\",\"id\":\"Q96C36\"},{\"label\":\"Pyrroline-5-carboxylate reductase 3\",\"id\":\"Q53H96\"}]", "uniprot_id": "[\"O94925\",\"P00367\",\"P00505\",\"P04181\",\"P15104\",\"P32322\",\"P49448\",\"Q16773\",\"Q53H96\",\"Q8IXN7\",\"Q96C36\",\"Q9UI32\",\"Q9ULI2\"]", "gene_symbol": "[\"CCBL1\",\"FAM80A\",\"FAM80B\",\"GA\",\"GLNS\",\"GLS\",\"GLS1\",\"GLS2\",\"GLUD\",\"GLUD1\",\"GLUD2\",\"GLUDP1\",\"GLUL\",\"GOT2\",\"KIAA0838\",\"KIAA1238\",\"KYAT1\",\"KYAT4\",\"OAT\",\"PYCR1\",\"PYCR2\",\"PYCR3\",\"PYCRL\",\"RIMKLA\",\"RIMKLB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Degradation of cysteine and homocysteine", "protein_name": "[{\"label\":\"2-aminoethanethiol dioxygenase\",\"id\":\"Q96SZ5\"},{\"label\":\"3-mercaptopyruvate sulfurtransferase\",\"id\":\"P25325\"},{\"label\":\"Acidic amino acid decarboxylase GADL1\",\"id\":\"Q6ZQY3\"},{\"label\":\"Aspartate aminotransferase, mitochondrial\",\"id\":\"P00505\"},{\"label\":\"Cystathionine gamma-lyase\",\"id\":\"P32929\"},{\"label\":\"Cysteine dioxygenase type 1\",\"id\":\"Q16878\"},{\"label\":\"Cysteine sulfinic acid decarboxylase\",\"id\":\"Q9Y600\"},{\"label\":\"Flavin-containing monooxygenase 1\",\"id\":\"Q01740\"},{\"label\":\"Thioredoxin, mitochondrial\",\"id\":\"Q99757\"},{\"label\":\"Thiosulfate sulfurtransferase\",\"id\":\"Q16762\"}]", "uniprot_id": "[\"P00505\",\"P25325\",\"P32929\",\"Q01740\",\"Q16762\",\"Q16878\",\"Q6ZQY3\",\"Q96SZ5\",\"Q99757\",\"Q9Y600\"]", "gene_symbol": "[\"ADO\",\"C10orf22\",\"CDO1\",\"CSAD\",\"CSD\",\"CTH\",\"FMO1\",\"GADL1\",\"GOT2\",\"KYAT4\",\"MPST\",\"TRX2\",\"TST\",\"TST2\",\"TXN2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of HIV-1 elongation complex containing HIV-1 Tat", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Elongin-A2\",\"id\":\"Q8IYF1\"},{\"label\":\"Elongin-A\",\"id\":\"Q14241\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"FACT complex subunit SPT16\",\"id\":\"Q9Y5B9\"},{\"label\":\"FACT complex subunit SSRP1\",\"id\":\"Q08945\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Negative elongation factor A\",\"id\":\"Q9H3P2\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"},{\"label\":\"Negative elongation factor C/D\",\"id\":\"Q8IXH7\"},{\"label\":\"Negative elongation factor E\",\"id\":\"P18615\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Protein Tat\",\"id\":\"P04608\"},{\"label\":\"RNA polymerase II elongation factor ELL\",\"id\":\"P55199\"},{\"label\":\"RNA polymerase II subunit A C-terminal domain phosphatase\",\"id\":\"Q9Y5B0\"},{\"label\":\"Transcription elongation factor A protein 1\",\"id\":\"P23193\"},{\"label\":\"Transcription elongation factor SPT4\",\"id\":\"P63272\"},{\"label\":\"Transcription elongation factor SPT5\",\"id\":\"O00267\"}]", "uniprot_id": 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"pathway_label": "Nicotinate metabolism", "protein_name": "[{\"label\":\"5'-nucleotidase\",\"id\":\"P21589\"},{\"label\":\"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1\",\"id\":\"P28907\"},{\"label\":\"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2\",\"id\":\"Q10588\"},{\"label\":\"Glutamine-dependent NAD(+) synthetase\",\"id\":\"Q6IA69\"},{\"label\":\"NAD kinase 2, mitochondrial\",\"id\":\"Q4G0N4\"},{\"label\":\"NAD kinase\",\"id\":\"O95544\"},{\"label\":\"Nicotinamide riboside kinase 1\",\"id\":\"Q9NWW6\"},{\"label\":\"Nicotinamide riboside kinase 2\",\"id\":\"Q9NPI5\"},{\"label\":\"Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1\",\"id\":\"Q9HAN9\"},{\"label\":\"Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2\",\"id\":\"Q9BZQ4\"},{\"label\":\"Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3\",\"id\":\"Q96T66\"},{\"label\":\"Nicotinate-nucleotide pyrophosphorylase [carboxylating]\",\"id\":\"Q15274\"}]", "uniprot_id": "[\"O95544\",\"P21589\",\"P28907\",\"Q10588\",\"Q15274\",\"Q4G0N4\",\"Q6IA69\",\"Q96T66\",\"Q9BZQ4\",\"Q9HAN9\",\"Q9NPI5\",\"Q9NWW6\"]", "gene_symbol": "[\"BST1\",\"C1orf15\",\"C5orf33\",\"C9orf95\",\"CD38\",\"ITGB1BP3\",\"KIAA0479\",\"MNADK\",\"NADK\",\"NADK2\",\"NADKD1\",\"NADSYN1\",\"NMNAT\",\"NMNAT1\",\"NMNAT2\",\"NMNAT3\",\"NMRK1\",\"NMRK2\",\"NRK1\",\"NRK2\",\"NT5\",\"NT5E\",\"NTE\",\"QPRT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ALG9 causes CDG-1l", "protein_name": "[{\"label\":\"Alpha-1,2-mannosyltransferase ALG9\",\"id\":\"Q9H6U8\"}]", "uniprot_id": "[\"Q9H6U8\"]", "gene_symbol": "[\"ALG9\",\"DIBD1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PI-3K cascade:FGFR2", "protein_name": "[{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 22\",\"id\":\"Q9HCT0\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 3\",\"id\":\"P11487\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 7\",\"id\":\"P21781\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O15520\",\"O43320\",\"O76093\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11487\",\"P21781\",\"P27986\",\"P31371\",\"P42336\",\"Q06124\",\"Q13480\",\"Q8WU20\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF10\",\"FGF16\",\"FGF18\",\"FGF2\",\"FGF20\",\"FGF22\",\"FGF23\",\"FGF3\",\"FGF4\",\"FGF6\",\"FGF7\",\"FGF9\",\"FGFA\",\"FGFB\",\"FRS2\",\"GAB1\",\"GRB1\",\"HST\",\"HST2\",\"HSTF1\",\"HSTF2\",\"HYPF\",\"INT2\",\"KGF\",\"KS3\",\"PIK3CA\",\"PIK3R1\",\"PTP2C\",\"PTPN11\",\"SHPTP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ALG3 causes CDG-1d", "protein_name": "[{\"label\":\"Dol-P-Man\",\"id\":\"Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase:Q92685\"}]", "uniprot_id": "[\"Q92685\"]", "gene_symbol": "[\"ALG3\",\"NOT\",\"NOT56L\"]", "gtc_id": "[\"G59406KS\"]" }, { "pathway_label": "Downregulation of TGF-beta receptor signaling", "protein_name": "[{\"label\":\"BMP and activin membrane-bound inhibitor homolog\",\"id\":\"Q13145\"},{\"label\":\"E3 ubiquitin-protein ligase CHIP\",\"id\":\"Q9UNE7\"},{\"label\":\"E3 ubiquitin-protein ligase NEDD4-like\",\"id\":\"Q96PU5\"},{\"label\":\"E3 ubiquitin-protein ligase SMURF1\",\"id\":\"Q9HCE7\"},{\"label\":\"E3 ubiquitin-protein ligase SMURF2\",\"id\":\"Q9HAU4\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"Mothers against decapentaplegic homolog 2\",\"id\":\"Q15796\"},{\"label\":\"Mothers against decapentaplegic homolog 3\",\"id\":\"P84022\"},{\"label\":\"Mothers against decapentaplegic homolog 7\",\"id\":\"O15105\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4\",\"id\":\"Q9NYA4\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein TMEPAI\",\"id\":\"Q969W9\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 15A\",\"id\":\"O75807\"},{\"label\":\"Serine-threonine kinase receptor-associated protein\",\"id\":\"Q9Y3F4\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-alpha catalytic subunit\",\"id\":\"P62136\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-beta catalytic subunit\",\"id\":\"P62140\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-gamma catalytic subunit\",\"id\":\"P36873\"},{\"label\":\"TGF-beta receptor type-1\",\"id\":\"P36897\"},{\"label\":\"TGF-beta receptor type-2\",\"id\":\"P37173\"},{\"label\":\"Transforming growth factor beta-1 proprotein\",\"id\":\"P01137\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 15\",\"id\":\"Q9Y4E8\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase isozyme L5\",\"id\":\"Q9Y5K5\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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beta/alpha\",\"id\":\"P31946\"},{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"14-3-3 protein eta\",\"id\":\"Q04917\"},{\"label\":\"14-3-3 protein gamma\",\"id\":\"P61981\"},{\"label\":\"14-3-3 protein sigma\",\"id\":\"P31947\"},{\"label\":\"14-3-3 protein theta\",\"id\":\"P27348\"},{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"3-phosphoinositide-dependent protein kinase 1\",\"id\":\"O15530\"},{\"label\":\"M-phase inducer phosphatase 3\",\"id\":\"P30307\"},{\"label\":\"Myosin light polypeptide 6\",\"id\":\"P60660\"},{\"label\":\"Myosin regulatory light chain 12B\",\"id\":\"O14950\"},{\"label\":\"Myosin regulatory light polypeptide 9\",\"id\":\"P24844\"},{\"label\":\"Myosin-10\",\"id\":\"P35580\"},{\"label\":\"Myosin-11\",\"id\":\"P35749\"},{\"label\":\"Myosin-14\",\"id\":\"Q7Z406\"},{\"label\":\"Myosin-9\",\"id\":\"P35579\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 12A\",\"id\":\"O14974\"},{\"label\":\"Protein phosphatase 1 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factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D1\",\"id\":\"P51668\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D2\",\"id\":\"P62837\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 D3\",\"id\":\"P61077\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 1\",\"id\":\"Q13404\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00206\",\"O14920\",\"O15111\",\"P08571\",\"P0CG47\",\"P0CG48\",\"P51668\",\"P61077\",\"P61088\",\"P62837\",\"P62979\",\"P62987\",\"Q13404\",\"Q13489\",\"Q13490\",\"Q13546\",\"Q86XR7\",\"Q8IUC6\",\"Q9Y4K3\",\"Q9Y572\",\"Q9Y6K9\",\"Q9Y6Y9\"]", "gene_symbol": 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"gene_symbol": "[\"DPC4\",\"MADH2\",\"MADH3\",\"MADH4\",\"MADR2\",\"SMAD2\",\"SMAD3\",\"SMAD4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis", "protein_name": "[{\"label\":\"Angiogenin\",\"id\":\"P03950\"},{\"label\":\"Endoribonuclease Dicer\",\"id\":\"Q9UPY3\"},{\"label\":\"Zinc phosphodiesterase ELAC protein 2\",\"id\":\"Q9BQ52\"}]", "uniprot_id": "[\"P03950\",\"Q9BQ52\",\"Q9UPY3\"]", "gene_symbol": "[\"ANG\",\"DICER\",\"DICER1\",\"ELAC2\",\"HERNA\",\"HPC2\",\"KIAA0928\",\"RNASE5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Aggrephagy", "protein_name": "[{\"label\":\"ADP-ribosylation factor-like protein 13B\",\"id\":\"Q3SXY8\"},{\"label\":\"Centrin-1\",\"id\":\"Q12798\"},{\"label\":\"Cystic fibrosis transmembrane conductance regulator\",\"id\":\"P13569\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 1\",\"id\":\"O14576\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 2\",\"id\":\"O43237\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"E3 ubiquitin-protein ligase parkin\",\"id\":\"O60260\"},{\"label\":\"Heat shock factor protein 1\",\"id\":\"Q00613\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Histone deacetylase 6\",\"id\":\"Q9UBN7\"},{\"label\":\"Intraflagellar transport protein 88 homolog\",\"id\":\"Q13099\"},{\"label\":\"Parkinson disease protein 7\",\"id\":\"Q99497\"},{\"label\":\"Pericentrin\",\"id\":\"O95613\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Transitional endoplasmic reticulum ATPase\",\"id\":\"P55072\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 1\",\"id\":\"Q13404\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O14576\",\"O43237\",\"O60260\",\"O95613\",\"P07900\",\"P0CG47\",\"P0CG48\",\"P13569\",\"P55072\",\"P61088\",\"P62979\",\"P62987\",\"P63167\",\"Q00613\",\"Q12798\",\"Q13099\",\"Q13404\",\"Q13409\",\"Q14204\",\"Q3SXY8\",\"Q96FJ2\",\"Q99497\",\"Q9UBN7\",\"Q9Y6G9\"]", "gene_symbol": 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"[\"ABCG5\",\"ABCG8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nef mediated downregulation of MHC class I complex cell surface expression", "protein_name": "[{\"label\":\"AP-1 complex subunit beta-1\",\"id\":\"Q10567\"},{\"label\":\"AP-1 complex subunit gamma-1\",\"id\":\"O43747\"},{\"label\":\"AP-1 complex subunit mu-1\",\"id\":\"Q9BXS5\"},{\"label\":\"AP-1 complex subunit mu-2\",\"id\":\"Q9Y6Q5\"},{\"label\":\"AP-1 complex subunit sigma-1A\",\"id\":\"P61966\"},{\"label\":\"AP-1 complex subunit sigma-2\",\"id\":\"P56377\"},{\"label\":\"AP-1 complex subunit sigma-3\",\"id\":\"Q96PC3\"},{\"label\":\"Beta-2-microglobulin\",\"id\":\"P61769\"},{\"label\":\"HLA class I histocompatibility antigen, A alpha chain\",\"id\":\"P04439\"},{\"label\":\"Phosphofurin acidic cluster sorting protein 1\",\"id\":\"Q6VY07\"},{\"label\":\"Protein Nef\",\"id\":\"P04601\"}]", "uniprot_id": "[\"O43747\",\"P04439\",\"P04601\",\"P56377\",\"P61769\",\"P61966\",\"Q10567\",\"Q6VY07\",\"Q96PC3\",\"Q9BXS5\",\"Q9Y6Q5\"]", "gene_symbol": "[\"ADTB1\",\"ADTG\",\"AP19\",\"AP1B1\",\"AP1G1\",\"AP1M1\",\"AP1M2\",\"AP1S1\",\"AP1S2\",\"AP1S3\",\"B2M\",\"BAM22\",\"CLAPB2\",\"CLAPG1\",\"CLAPS1\",\"CLTNM\",\"HLA-A\",\"HLAA\",\"KIAA1175\",\"PACS1\",\"nef\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Androgen biosynthesis", "protein_name": "[{\"label\":\"17-beta-hydroxysteroid dehydrogenase type 3\",\"id\":\"P37058\"},{\"label\":\"3 beta-hydroxysteroid dehydrogenase/Delta 5--\\u003e4-isomerase type 1\",\"id\":\"P14060\"},{\"label\":\"3 beta-hydroxysteroid dehydrogenase/Delta 5--\\u003e4-isomerase type 2\",\"id\":\"P26439\"},{\"label\":\"3-oxo-5-alpha-steroid 4-dehydrogenase 1\",\"id\":\"P18405\"},{\"label\":\"3-oxo-5-alpha-steroid 4-dehydrogenase 2\",\"id\":\"P31213\"},{\"label\":\"Glycoprotein hormones alpha chain\",\"id\":\"P01215\"},{\"label\":\"Lutropin subunit beta\",\"id\":\"P01229\"},{\"label\":\"Polyprenal reductase\",\"id\":\"Q9H8P0\"},{\"label\":\"Pro-opiomelanocortin\",\"id\":\"P01189\"},{\"label\":\"Steroid 17-alpha-hydroxylase/17,20 lyase\",\"id\":\"P05093\"},{\"label\":\"Very-long-chain 3-oxoacyl-CoA reductase\",\"id\":\"Q53GQ0\"}]", "uniprot_id": "[\"P01189\",\"P01215\",\"P01229\",\"P05093\",\"P14060\",\"P18405\",\"P26439\",\"P31213\",\"P37058\",\"Q53GQ0\",\"Q9H8P0\"]", "gene_symbol": "[\"3BH\",\"CGA\",\"CYP17\",\"CYP17A1\",\"EDH17B3\",\"HSD17B12\",\"HSD17B3\",\"HSD3B1\",\"HSD3B2\",\"HSDB3A\",\"HSDB3B\",\"LHB\",\"POMC\",\"S17AH\",\"SDR12C1\",\"SDR12C2\",\"SRD5A1\",\"SRD5A2\",\"SRD5A2L\",\"SRD5A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G1/S-Specific Transcription", "protein_name": "[{\"label\":\"Cell division control protein 45 homolog\",\"id\":\"O75419\"},{\"label\":\"Cell division control protein 6 homolog\",\"id\":\"Q99741\"},{\"label\":\"Cyclin-A1\",\"id\":\"P78396\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"DNA polymerase alpha catalytic subunit\",\"id\":\"P09884\"},{\"label\":\"DNA replication factor Cdt1\",\"id\":\"Q9H211\"},{\"label\":\"Dihydrofolate reductase\",\"id\":\"P00374\"},{\"label\":\"F-box only protein 5\",\"id\":\"Q9UKT4\"},{\"label\":\"G1/S-specific cyclin-E1\",\"id\":\"P24864\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Origin recognition complex subunit 1\",\"id\":\"Q13415\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"Protein lin-37 homolog\",\"id\":\"Q96GY3\"},{\"label\":\"Protein lin-52 homolog\",\"id\":\"Q52LA3\"},{\"label\":\"Protein lin-54 homolog\",\"id\":\"Q6MZP7\"},{\"label\":\"Protein lin-9 homolog\",\"id\":\"Q5TKA1\"},{\"label\":\"Retinoblastoma-like protein 1\",\"id\":\"P28749\"},{\"label\":\"Retinoblastoma-like protein 2\",\"id\":\"Q08999\"},{\"label\":\"Ribonucleoside-diphosphate reductase subunit M2\",\"id\":\"P31350\"},{\"label\":\"Thymidine kinase, cytosolic\",\"id\":\"P04183\"},{\"label\":\"Thymidylate synthase\",\"id\":\"P04818\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Transcription factor E2F4\",\"id\":\"Q16254\"},{\"label\":\"Transcription factor E2F5\",\"id\":\"Q15329\"},{\"label\":\"Transcription factor E2F6\",\"id\":\"O75461\"}]", "uniprot_id": "[\"O75419\",\"O75461\",\"P00374\",\"P04183\",\"P04818\",\"P06493\",\"P09884\",\"P12004\",\"P24864\",\"P28749\",\"P31350\",\"P78396\",\"Q01094\",\"Q08999\",\"Q09028\",\"Q13415\",\"Q13547\",\"Q14186\",\"Q14188\",\"Q15329\",\"Q16254\",\"Q52LA3\",\"Q5TKA1\",\"Q6MZP7\",\"Q96GY3\",\"Q99741\",\"Q9H211\",\"Q9UKT4\"]", "gene_symbol": 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ubiquitin-protein ligase RING2\",\"id\":\"Q99496\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein K\",\"id\":\"P61978\"},{\"label\":\"Heterogeneous nuclear ribonucleoproteins C1/C2\",\"id\":\"P07910\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleolar protein 58\",\"id\":\"Q9Y2X3\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Polycomb complex protein BMI-1\",\"id\":\"P35226\"},{\"label\":\"Polycomb group RING finger protein 2\",\"id\":\"P35227\"},{\"label\":\"Polyhomeotic-like protein 1\",\"id\":\"P78364\"},{\"label\":\"Polyhomeotic-like protein 2\",\"id\":\"Q8IXK0\"},{\"label\":\"Polyhomeotic-like protein 3\",\"id\":\"Q8NDX5\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"},{\"label\":\"Small ubiquitin-related modifier 2\",\"id\":\"P61956\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": "[\"A8CG34\",\"O00257\",\"O15504\",\"O75694\",\"P07910\",\"P12270\",\"P35226\",\"P35227\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P55735\",\"P57740\",\"P61956\",\"P61978\",\"P63165\",\"P63279\",\"P78364\",\"P78406\",\"Q06587\",\"Q12769\",\"Q14781\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8IXK0\",\"Q8N1F7\",\"Q8NDX5\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q96HA1\",\"Q99496\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9HC52\",\"Q9NRG9\",\"Q9UKX7\",\"Q9Y2X3\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Loss of Nlp from mitotic centrosomes", "protein_name": "[{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"14-3-3 protein gamma\",\"id\":\"P61981\"},{\"label\":\"A-kinase anchor protein 9\",\"id\":\"Q99996\"},{\"label\":\"Alpha-centractin\",\"id\":\"P61163\"},{\"label\":\"CDK5 regulatory subunit-associated protein 2\",\"id\":\"Q96SN8\"},{\"label\":\"CLIP-associating protein 1\",\"id\":\"Q7Z460\"},{\"label\":\"Casein kinase I isoform delta\",\"id\":\"P48730\"},{\"label\":\"Casein kinase I isoform epsilon\",\"id\":\"P49674\"},{\"label\":\"Centrin-2\",\"id\":\"P41208\"},{\"label\":\"Centriolar coiled-coil protein of 110 kDa\",\"id\":\"O43303\"},{\"label\":\"Centriole and centriolar satellite protein OFD1\",\"id\":\"O75665\"},{\"label\":\"Centriolin\",\"id\":\"Q7Z7A1\"},{\"label\":\"Centromere protein J\",\"id\":\"Q9HC77\"},{\"label\":\"Centrosomal protein 43\",\"id\":\"O95684\"},{\"label\":\"Centrosomal protein of 131 kDa\",\"id\":\"Q9UPN4\"},{\"label\":\"Centrosomal protein of 135 kDa\",\"id\":\"Q66GS9\"},{\"label\":\"Centrosomal protein of 152 kDa\",\"id\":\"O94986\"},{\"label\":\"Centrosomal protein of 164 kDa\",\"id\":\"Q9UPV0\"},{\"label\":\"Centrosomal protein of 192 kDa\",\"id\":\"Q8TEP8\"},{\"label\":\"Centrosomal protein of 290 kDa\",\"id\":\"O15078\"},{\"label\":\"Centrosomal protein of 41 kDa\",\"id\":\"Q9BYV8\"},{\"label\":\"Centrosomal protein of 57 kDa\",\"id\":\"Q86XR8\"},{\"label\":\"Centrosomal protein of 63 kDa\",\"id\":\"Q96MT8\"},{\"label\":\"Centrosomal protein of 70 kDa\",\"id\":\"Q8NHQ1\"},{\"label\":\"Centrosomal protein of 72 kDa\",\"id\":\"Q9P209\"},{\"label\":\"Centrosomal protein of 76 kDa\",\"id\":\"Q8TAP6\"},{\"label\":\"Centrosomal protein of 78 kDa\",\"id\":\"Q5JTW2\"},{\"label\":\"Centrosome-associated protein ALMS1\",\"id\":\"Q8TCU4\"},{\"label\":\"Centrosome-associated protein CEP250\",\"id\":\"Q9BV73\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoskeleton-associated protein 5\",\"id\":\"Q14008\"},{\"label\":\"Dynactin subunit 2\",\"id\":\"Q13561\"},{\"label\":\"Dynactin subunit 3\",\"id\":\"O75935\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"HAUS augmin-like complex subunit 1\",\"id\":\"Q96CS2\"},{\"label\":\"HAUS augmin-like complex subunit 2\",\"id\":\"Q9NVX0\"},{\"label\":\"HAUS augmin-like complex subunit 3\",\"id\":\"Q68CZ6\"},{\"label\":\"HAUS augmin-like complex subunit 4\",\"id\":\"Q9H6D7\"},{\"label\":\"HAUS augmin-like complex subunit 5\",\"id\":\"O94927\"},{\"label\":\"HAUS augmin-like complex subunit 6\",\"id\":\"Q7Z4H7\"},{\"label\":\"HAUS augmin-like complex subunit 7\",\"id\":\"Q99871\"},{\"label\":\"HAUS augmin-like complex subunit 8\",\"id\":\"Q9BT25\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Microtubule nucleation factor SSNA1\",\"id\":\"O43805\"},{\"label\":\"Microtubule-associated protein RP/EB family member 1\",\"id\":\"Q15691\"},{\"label\":\"Ninein-like protein\",\"id\":\"Q9Y2I6\"},{\"label\":\"Nuclear distribution protein nudE homolog 1\",\"id\":\"Q9NXR1\"},{\"label\":\"Outer dense fiber protein 2\",\"id\":\"Q5BJF6\"},{\"label\":\"Pericentrin\",\"id\":\"O95613\"},{\"label\":\"Pericentriolar material 1 protein\",\"id\":\"Q15154\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit beta\",\"id\":\"P43034\"},{\"label\":\"Protein NEDD1\",\"id\":\"Q8NHV4\"},{\"label\":\"Protein SFI1 homolog\",\"id\":\"A8K8P3\"},{\"label\":\"Serine/threonine-protein kinase Nek2\",\"id\":\"P51955\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"},{\"label\":\"Serine/threonine-protein kinase PLK4\",\"id\":\"O00444\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha 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"gtc_id": "[\"\"]" }, { "pathway_label": "Formation of annular gap junctions", "protein_name": "[{\"label\":\"AP-2 complex subunit mu\",\"id\":\"Q96CW1\"},{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Clathrin heavy chain 2\",\"id\":\"P53675\"},{\"label\":\"Clathrin light chain A\",\"id\":\"P09496\"},{\"label\":\"Clathrin light chain B\",\"id\":\"P09497\"},{\"label\":\"Disabled homolog 2\",\"id\":\"P98082\"},{\"label\":\"Dynamin-1\",\"id\":\"Q05193\"},{\"label\":\"Dynamin-2\",\"id\":\"P50570\"},{\"label\":\"Gap junction alpha-1 protein\",\"id\":\"P17302\"}]", "uniprot_id": "[\"P09496\",\"P09497\",\"P17302\",\"P50570\",\"P53675\",\"P98082\",\"Q00610\",\"Q05193\",\"Q96CW1\"]", "gene_symbol": "[\"AP2M1\",\"CLAPM1\",\"CLH17\",\"CLH22\",\"CLTA\",\"CLTB\",\"CLTC\",\"CLTCL\",\"CLTCL1\",\"CLTCL2\",\"CLTD\",\"DAB2\",\"DNM\",\"DNM1\",\"DNM2\",\"DOC2\",\"DYN2\",\"GJA1\",\"GJAL\",\"KIAA0034\",\"KIAA0109\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Free fatty acid receptors", "protein_name": "[{\"label\":\"12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor\",\"id\":\"O00270\"},{\"label\":\"Free fatty acid receptor 1\",\"id\":\"O14842\"},{\"label\":\"Free fatty acid receptor 2\",\"id\":\"O15552\"},{\"label\":\"Free fatty acid receptor 3\",\"id\":\"O14843\"},{\"label\":\"Free fatty acid receptor 4\",\"id\":\"Q5NUL3\"}]", "uniprot_id": "[\"O00270\",\"O14842\",\"O14843\",\"O15552\",\"Q5NUL3\"]", "gene_symbol": "[\"FFA2\",\"FFAR1\",\"FFAR2\",\"FFAR3\",\"FFAR4\",\"GPCR43\",\"GPR120\",\"GPR129\",\"GPR31\",\"GPR40\",\"GPR41\",\"GPR43\",\"O3FAR1\",\"PGR4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Translation of Structural Proteins", "protein_name": "[{\"label\":\"Envelope small membrane protein\",\"id\":\"P0DTC4\"},{\"label\":\"Membrane protein\",\"id\":\"P0DTC5\"},{\"label\":\"Nucleoprotein\",\"id\":\"P0DTC9\"},{\"label\":\"ORF3a protein\",\"id\":\"P0DTC3\"},{\"label\":\"Spike glycoprotein\",\"id\":\"P0DTC2\"}]", "uniprot_id": "[\"P0DTC2\",\"P0DTC3\",\"P0DTC4\",\"P0DTC5\",\"P0DTC9\"]", "gene_symbol": "[\"3a\",\"E\",\"M\",\"N\",\"S\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HCN channels", "protein_name": "[{\"label\":\"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1\",\"id\":\"O60741\"},{\"label\":\"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2\",\"id\":\"Q9UL51\"},{\"label\":\"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3\",\"id\":\"Q9P1Z3\"},{\"label\":\"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4\",\"id\":\"Q9Y3Q4\"}]", "uniprot_id": "[\"O60741\",\"Q9P1Z3\",\"Q9UL51\",\"Q9Y3Q4\"]", "gene_symbol": "[\"BCNG1\",\"BCNG2\",\"HCN1\",\"HCN2\",\"HCN3\",\"HCN4\",\"KIAA1535\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ChREBP activates metabolic gene expression", "protein_name": "[{\"label\":\"1-acyl-sn-glycerol-3-phosphate acyltransferase alpha\",\"id\":\"Q99943\"},{\"label\":\"ATP-citrate synthase\",\"id\":\"P53396\"},{\"label\":\"Acetyl-CoA carboxylase 1\",\"id\":\"Q13085\"},{\"label\":\"Acetyl-CoA carboxylase 2\",\"id\":\"O00763\"},{\"label\":\"Carbohydrate-responsive element-binding protein\",\"id\":\"Q9NP71\"},{\"label\":\"Fatty acid synthase\",\"id\":\"P49327\"},{\"label\":\"Max-like protein X\",\"id\":\"Q9UH92\"}]", "uniprot_id": "[\"O00763\",\"P49327\",\"P53396\",\"Q13085\",\"Q99943\",\"Q9NP71\",\"Q9UH92\"]", "gene_symbol": "[\"ACAC\",\"ACACA\",\"ACACB\",\"ACC1\",\"ACC2\",\"ACCA\",\"ACCB\",\"ACLY\",\"AGPAT1\",\"BHLHD13\",\"BHLHD14\",\"FAS\",\"FASN\",\"G15\",\"MIO\",\"MLX\",\"MLXIPL\",\"TCFL4\",\"WBSCR14\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Pexophagy", "protein_name": "[{\"label\":\"Endothelial PAS domain-containing protein 1\",\"id\":\"Q99814\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 3B\",\"id\":\"Q9GZQ8\"},{\"label\":\"Next to BRCA1 gene 1 protein\",\"id\":\"Q14596\"},{\"label\":\"Peroxisomal targeting signal 1 receptor\",\"id\":\"P50542\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Sequestosome-1\",\"id\":\"Q13501\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 30\",\"id\":\"Q70CQ3\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"P0CG47\",\"P0CG48\",\"P50542\",\"P62979\",\"P62987\",\"Q13315\",\"Q13501\",\"Q14596\",\"Q70CQ3\",\"Q99814\",\"Q9GZQ8\"]", "gene_symbol": "[\"1A13B\",\"ATM\",\"BHLHE73\",\"EPAS1\",\"HIF2A\",\"KIAA0049\",\"M17S2\",\"MAP1ALC3\",\"MAP1LC3B\",\"MOP2\",\"NBR1\",\"ORCA\",\"OSIL\",\"PASD2\",\"PEX5\",\"PXR1\",\"RPS27A\",\"SQSTM1\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"USP30\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Toll Like Receptor 4 (TLR4) Cascade", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2\",\"id\":\"P16885\"},{\"label\":\"Bactericidal permeability-increasing protein\",\"id\":\"P17213\"},{\"label\":\"CD180 antigen\",\"id\":\"Q99467\"},{\"label\":\"Dynamin-1\",\"id\":\"Q05193\"},{\"label\":\"Dynamin-2\",\"id\":\"P50570\"},{\"label\":\"Dynamin-3\",\"id\":\"Q9UQ16\"},{\"label\":\"Integrin alpha-M\",\"id\":\"P11215\"},{\"label\":\"Integrin beta-2\",\"id\":\"P05107\"},{\"label\":\"Lipopolysaccharide-binding protein\",\"id\":\"P18428\"},{\"label\":\"Lymphocyte antigen 86\",\"id\":\"O95711\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"TIR domain-containing adapter molecule 2\",\"id\":\"Q86XR7\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 4\",\"id\":\"P29074\"}]", "uniprot_id": "[\"O00206\",\"O95711\",\"P05107\",\"P08571\",\"P11215\",\"P16885\",\"P17213\",\"P18428\",\"P29074\",\"P50570\",\"Q05193\",\"Q86XR7\",\"Q99467\",\"Q9UQ16\",\"Q9Y6Y9\"]", "gene_symbol": "[\"BPI\",\"CD11B\",\"CD14\",\"CD18\",\"CD180\",\"CR3A\",\"DNM\",\"DNM1\",\"DNM2\",\"DNM3\",\"DYN2\",\"ESOP1\",\"ITGAM\",\"ITGB2\",\"KIAA0820\",\"LBP\",\"LY64\",\"LY86\",\"LY96\",\"MD1\",\"MD2\",\"MFI7\",\"PLCG2\",\"PTPN4\",\"RP105\",\"TICAM2\",\"TIRAP3\",\"TIRP\",\"TLR4\",\"TRAM\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Fatty acyl-CoA biosynthesis", "protein_name": "[{\"label\":\"(3R)-3-hydroxyacyl-CoA dehydrogenase\",\"id\":\"Q92506\"},{\"label\":\"3-oxoacyl-[acyl-carrier-protein] reductase\",\"id\":\"Q8N4T8\"},{\"label\":\"ATP-citrate synthase\",\"id\":\"P53396\"},{\"label\":\"ATPase MORC2\",\"id\":\"Q9Y6X9\"},{\"label\":\"Acetyl-CoA carboxylase 1\",\"id\":\"Q13085\"},{\"label\":\"Fatty acid synthase\",\"id\":\"P49327\"},{\"label\":\"Hydroxyacyl-thioester dehydratase type 2, mitochondrial\",\"id\":\"P86397\"},{\"label\":\"Long-chain fatty acid transport protein 2\",\"id\":\"O14975\"},{\"label\":\"Lysosomal thioesterase PPT2\",\"id\":\"Q9UMR5\"},{\"label\":\"Palmitoyl-protein thioesterase 1\",\"id\":\"P50897\"},{\"label\":\"S-acyl fatty acid synthase thioesterase, medium chain\",\"id\":\"Q9NV23\"},{\"label\":\"Stearoyl-CoA desaturase 5\",\"id\":\"Q86SK9\"},{\"label\":\"Stearoyl-CoA desaturase\",\"id\":\"O00767\"}]", "uniprot_id": "[\"O00767\",\"O14975\",\"P49327\",\"P50897\",\"P53396\",\"P86397\",\"Q13085\",\"Q86SK9\",\"Q8N4T8\",\"Q92506\",\"Q9NV23\",\"Q9UMR5\",\"Q9Y6X9\"]", "gene_symbol": 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mitochondrial\",\"id\":\"P31327\"},{\"label\":\"Mitochondrial ornithine transporter 1\",\"id\":\"Q9Y619\"},{\"label\":\"Mitochondrial ornithine transporter 2\",\"id\":\"Q9BXI2\"},{\"label\":\"N-acetylglutamate synthase, mitochondrial\",\"id\":\"Q8N159\"},{\"label\":\"NmrA-like family domain-containing protein 1\",\"id\":\"Q9HBL8\"},{\"label\":\"Ornithine transcarbamylase, mitochondrial\",\"id\":\"P00480\"}]", "uniprot_id": "[\"P00480\",\"P00966\",\"P04424\",\"P05089\",\"P31327\",\"P78540\",\"Q8N159\",\"Q9BXI2\",\"Q9HBL8\",\"Q9Y619\"]", "gene_symbol": "[\"ARG1\",\"ARG2\",\"ASL\",\"ASS\",\"ASS1\",\"CPS1\",\"HSCARG\",\"NAGS\",\"NMRAL1\",\"ORC1\",\"ORC2\",\"ORNT1\",\"ORNT2\",\"OTC\",\"SLC25A15\",\"SLC25A2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Respiratory electron transport", "protein_name": "[{\"label\":\"Acyl carrier protein, mitochondrial\",\"id\":\"O14561\"},{\"label\":\"Coenzyme Q-binding protein COQ10 homolog A, mitochondrial\",\"id\":\"Q96MF6\"},{\"label\":\"Coenzyme Q-binding protein COQ10 homolog B, mitochondrial\",\"id\":\"Q9H8M1\"},{\"label\":\"Cytochrome b-c1 complex subunit 1, mitochondrial\",\"id\":\"P31930\"},{\"label\":\"Cytochrome b-c1 complex subunit 10\",\"id\":\"O14957\"},{\"label\":\"Cytochrome b-c1 complex subunit 2, mitochondrial\",\"id\":\"P22695\"},{\"label\":\"Cytochrome b-c1 complex subunit 6, mitochondrial\",\"id\":\"P07919\"},{\"label\":\"Cytochrome b-c1 complex subunit 7\",\"id\":\"P14927\"},{\"label\":\"Cytochrome b-c1 complex subunit 8\",\"id\":\"O14949\"},{\"label\":\"Cytochrome b-c1 complex subunit 9\",\"id\":\"Q9UDW1\"},{\"label\":\"Cytochrome b-c1 complex subunit Rieske, mitochondrial\",\"id\":\"P47985\"},{\"label\":\"Cytochrome b\",\"id\":\"P00156\"},{\"label\":\"Cytochrome c oxidase assembly factor 1 homolog\",\"id\":\"Q9GZY4\"},{\"label\":\"Cytochrome c oxidase subunit 1\",\"id\":\"P00395\"},{\"label\":\"Cytochrome c oxidase subunit 2\",\"id\":\"P00403\"},{\"label\":\"Cytochrome c oxidase subunit 3\",\"id\":\"P00414\"},{\"label\":\"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial\",\"id\":\"P13073\"},{\"label\":\"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial\",\"id\":\"Q96KJ9\"},{\"label\":\"Cytochrome c oxidase subunit 5A, mitochondrial\",\"id\":\"P20674\"},{\"label\":\"Cytochrome c oxidase subunit 5B, mitochondrial\",\"id\":\"P10606\"},{\"label\":\"Cytochrome c oxidase subunit 6A1, mitochondrial\",\"id\":\"P12074\"},{\"label\":\"Cytochrome c oxidase subunit 6A2, mitochondrial\",\"id\":\"Q02221\"},{\"label\":\"Cytochrome c oxidase subunit 6B1\",\"id\":\"P14854\"},{\"label\":\"Cytochrome c oxidase subunit 6B2\",\"id\":\"Q6YFQ2\"},{\"label\":\"Cytochrome c oxidase subunit 6C\",\"id\":\"P09669\"},{\"label\":\"Cytochrome c oxidase subunit 7A-related protein, mitochondrial\",\"id\":\"O14548\"},{\"label\":\"Cytochrome c oxidase subunit 7A1, mitochondrial\",\"id\":\"P24310\"},{\"label\":\"Cytochrome c oxidase subunit 7A2, mitochondrial\",\"id\":\"P14406\"},{\"label\":\"Cytochrome c oxidase subunit 7B, mitochondrial\",\"id\":\"P24311\"},{\"label\":\"Cytochrome c oxidase subunit 7C, mitochondrial\",\"id\":\"P15954\"},{\"label\":\"Cytochrome c oxidase subunit 8A, mitochondrial\",\"id\":\"P10176\"},{\"label\":\"Cytochrome c oxidase subunit 8C, mitochondrial\",\"id\":\"Q7Z4L0\"},{\"label\":\"Cytochrome c oxidase subunit NDUFA4\",\"id\":\"O00483\"},{\"label\":\"Cytochrome c1, heme protein, mitochondrial\",\"id\":\"P08574\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"Electron transfer flavoprotein subunit alpha, mitochondrial\",\"id\":\"P13804\"},{\"label\":\"Electron transfer flavoprotein subunit beta\",\"id\":\"P38117\"},{\"label\":\"Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial\",\"id\":\"Q16134\"},{\"label\":\"HIG1 domain family member 1C\",\"id\":\"A8MV81\"},{\"label\":\"Heat shock protein 75 kDa, mitochondrial\",\"id\":\"Q12931\"},{\"label\":\"Holocytochrome c-type synthase\",\"id\":\"P53701\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial\",\"id\":\"O95299\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11\",\"id\":\"Q86Y39\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12\",\"id\":\"Q9UI09\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13\",\"id\":\"Q9P0J0\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1\",\"id\":\"O15239\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2\",\"id\":\"O43678\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3\",\"id\":\"O95167\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5\",\"id\":\"Q16718\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6\",\"id\":\"P56556\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 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mitochondrial\",\"id\":\"O75489\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial\",\"id\":\"O43181\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5\",\"id\":\"O43920\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial\",\"id\":\"O75380\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial\",\"id\":\"O75251\"},{\"label\":\"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial\",\"id\":\"O00217\"},{\"label\":\"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial\",\"id\":\"P28331\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 1\",\"id\":\"P03886\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 2\",\"id\":\"P03891\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 3\",\"id\":\"P03897\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 4\",\"id\":\"P03905\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 5\",\"id\":\"P03915\"},{\"label\":\"NADH-ubiquinone oxidoreductase chain 6\",\"id\":\"P03923\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial\",\"id\":\"O14521\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial\",\"id\":\"P31040\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial\",\"id\":\"P21912\"},{\"label\":\"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial\",\"id\":\"Q99643\"},{\"label\":\"Transmembrane protein 186\",\"id\":\"Q96B77\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCB4 causes PFIC3, ICP3 and GBD1", "protein_name": "[{\"label\":\"Phosphatidylcholine translocator ABCB4\",\"id\":\"P21439\"}]", "uniprot_id": "[\"P21439\"]", "gene_symbol": "[\"ABCB4\",\"MDR3\",\"PGY3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MET activates STAT3", "protein_name": "[{\"label\":\"Hepatocyte growth factor receptor\",\"id\":\"P08581\"},{\"label\":\"Hepatocyte growth factor\",\"id\":\"P14210\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"}]", "uniprot_id": "[\"P08581\",\"P14210\",\"P40763\"]", "gene_symbol": "[\"APRF\",\"HGF\",\"HPTA\",\"MET\",\"STAT3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Response of EIF2AK1 (HRI) to heme deficiency", "protein_name": "[{\"label\":\"Asparagine synthetase [glutamine-hydrolyzing]\",\"id\":\"P08243\"},{\"label\":\"CCAAT/enhancer-binding protein beta\",\"id\":\"P17676\"},{\"label\":\"CCAAT/enhancer-binding protein gamma\",\"id\":\"P53567\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-3\",\"id\":\"P18847\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-4\",\"id\":\"P18848\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-5\",\"id\":\"Q9Y2D1\"},{\"label\":\"DNA damage-inducible transcript 3 protein\",\"id\":\"P35638\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 1\",\"id\":\"P05198\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 2\",\"id\":\"P20042\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 3\",\"id\":\"P41091\"},{\"label\":\"Eukaryotic translation initiation factor 2-alpha kinase 1\",\"id\":\"Q9BQI3\"},{\"label\":\"Glutathione-specific gamma-glutamylcyclotransferase 1\",\"id\":\"Q9BUX1\"},{\"label\":\"Growth factor receptor-bound protein 10\",\"id\":\"Q13322\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 15A\",\"id\":\"O75807\"},{\"label\":\"Tribbles homolog 3\",\"id\":\"Q96RU7\"}]", 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protein 43\",\"id\":\"O95684\"},{\"label\":\"Centrosomal protein of 131 kDa\",\"id\":\"Q9UPN4\"},{\"label\":\"Centrosomal protein of 135 kDa\",\"id\":\"Q66GS9\"},{\"label\":\"Centrosomal protein of 152 kDa\",\"id\":\"O94986\"},{\"label\":\"Centrosomal protein of 164 kDa\",\"id\":\"Q9UPV0\"},{\"label\":\"Centrosomal protein of 192 kDa\",\"id\":\"Q8TEP8\"},{\"label\":\"Centrosomal protein of 290 kDa\",\"id\":\"O15078\"},{\"label\":\"Centrosomal protein of 41 kDa\",\"id\":\"Q9BYV8\"},{\"label\":\"Centrosomal protein of 57 kDa\",\"id\":\"Q86XR8\"},{\"label\":\"Centrosomal protein of 63 kDa\",\"id\":\"Q96MT8\"},{\"label\":\"Centrosomal protein of 70 kDa\",\"id\":\"Q8NHQ1\"},{\"label\":\"Centrosomal protein of 72 kDa\",\"id\":\"Q9P209\"},{\"label\":\"Centrosomal protein of 76 kDa\",\"id\":\"Q8TAP6\"},{\"label\":\"Centrosomal protein of 78 kDa\",\"id\":\"Q5JTW2\"},{\"label\":\"Centrosome-associated protein ALMS1\",\"id\":\"Q8TCU4\"},{\"label\":\"Centrosome-associated protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Activated NOTCH1 Transmits Signal to the Nucleus", "protein_name": "[{\"label\":\"Beta-arrestin-1\",\"id\":\"P49407\"},{\"label\":\"Beta-arrestin-2\",\"id\":\"P32121\"},{\"label\":\"Contactin-1\",\"id\":\"Q12860\"},{\"label\":\"Delta and Notch-like epidermal growth factor-related receptor\",\"id\":\"Q8NFT8\"},{\"label\":\"Delta-like protein 1\",\"id\":\"O00548\"},{\"label\":\"Delta-like protein 4\",\"id\":\"Q9NR61\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 10\",\"id\":\"O14672\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 17\",\"id\":\"P78536\"},{\"label\":\"E3 ubiquitin-protein ligase DTX1\",\"id\":\"Q86Y01\"},{\"label\":\"E3 ubiquitin-protein ligase DTX4\",\"id\":\"Q9Y2E6\"},{\"label\":\"E3 ubiquitin-protein ligase Itchy homolog\",\"id\":\"Q96J02\"},{\"label\":\"E3 ubiquitin-protein ligase MIB1\",\"id\":\"Q86YT6\"},{\"label\":\"E3 ubiquitin-protein ligase MIB2\",\"id\":\"Q96AX9\"},{\"label\":\"E3 ubiquitin-protein ligase NEURL1\",\"id\":\"O76050\"},{\"label\":\"E3 ubiquitin-protein ligase NEURL1B\",\"id\":\"A8MQ27\"},{\"label\":\"Gamma-secretase subunit APH-1A\",\"id\":\"Q96BI3\"},{\"label\":\"Gamma-secretase subunit APH-1B\",\"id\":\"Q8WW43\"},{\"label\":\"Gamma-secretase subunit PEN-2\",\"id\":\"Q9NZ42\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Nicastrin\",\"id\":\"Q92542\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Presenilin-1\",\"id\":\"P49768\"},{\"label\":\"Presenilin-2\",\"id\":\"P49810\"},{\"label\":\"Probable E3 ubiquitin-protein ligase DTX2\",\"id\":\"Q86UW9\"},{\"label\":\"Protein delta homolog 1\",\"id\":\"P80370\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Protein jagged-2\",\"id\":\"Q9Y219\"},{\"label\":\"Protein numb homolog\",\"id\":\"P49757\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"A8MQ27\",\"O00548\",\"O14672\",\"O76050\",\"P0CG47\",\"P0CG48\",\"P32121\",\"P46531\",\"P49407\",\"P49757\",\"P49768\",\"P49810\",\"P62979\",\"P62987\",\"P78504\",\"P78536\",\"P80370\",\"Q12860\",\"Q86UW9\",\"Q86Y01\",\"Q86YT6\",\"Q8NFT8\",\"Q8WW43\",\"Q92542\",\"Q96AX9\",\"Q96BI3\",\"Q96J02\",\"Q9NR61\",\"Q9NZ42\",\"Q9Y219\",\"Q9Y2E6\"]", "gene_symbol": 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protein\",\"id\":\"Q99816\"},{\"label\":\"Ubiquitin-associated protein 1\",\"id\":\"Q9NZ09\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Vacuolar protein sorting-associated protein 28 homolog\",\"id\":\"Q9UK41\"},{\"label\":\"Vacuolar protein sorting-associated protein 37A\",\"id\":\"Q8NEZ2\"},{\"label\":\"Vacuolar protein sorting-associated protein 37B\",\"id\":\"Q9H9H4\"},{\"label\":\"Vacuolar protein sorting-associated protein 37C\",\"id\":\"A5D8V6\"},{\"label\":\"Vacuolar protein sorting-associated protein 37D\",\"id\":\"Q86XT2\"},{\"label\":\"Vacuolar protein sorting-associated protein 4A\",\"id\":\"Q9UN37\"},{\"label\":\"Vacuolar protein sorting-associated protein 4B\",\"id\":\"O75351\"},{\"label\":\"Vacuolar protein sorting-associated protein VTA1 homolog\",\"id\":\"Q9NP79\"},{\"label\":\"Vacuolar protein-sorting-associated protein 25\",\"id\":\"Q9BRG1\"},{\"label\":\"Vacuolar protein-sorting-associated protein 36\",\"id\":\"Q86VN1\"},{\"label\":\"Vacuolar-sorting protein SNF8\",\"id\":\"Q96H20\"}]", "uniprot_id": "[\"A5D8V6\",\"O14964\",\"O43633\",\"O75351\",\"O75886\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q86VN1\",\"Q86XT2\",\"Q8NEZ2\",\"Q8WUX9\",\"Q92783\",\"Q96CF2\",\"Q96EY5\",\"Q96FZ7\",\"Q96H20\",\"Q99816\",\"Q9BRG1\",\"Q9BY43\",\"Q9H444\",\"Q9H7P6\",\"Q9H9H4\",\"Q9NP79\",\"Q9NZ09\",\"Q9NZZ3\",\"Q9UK41\",\"Q9UN37\",\"Q9UQN3\",\"Q9Y3E7\"]", "gene_symbol": 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protein\",\"id\":\"P98160\"},{\"label\":\"Beta-galactosidase-1-like protein 2\",\"id\":\"Q8IW92\"},{\"label\":\"Beta-galactosidase-1-like protein 3\",\"id\":\"Q8NCI6\"},{\"label\":\"Beta-galactosidase-1-like protein\",\"id\":\"Q6UWU2\"},{\"label\":\"Beta-galactosidase\",\"id\":\"P16278\"},{\"label\":\"Beta-glucuronidase\",\"id\":\"P08236\"},{\"label\":\"Glypican-1\",\"id\":\"P35052\"},{\"label\":\"Glypican-2\",\"id\":\"Q8N158\"},{\"label\":\"Glypican-3\",\"id\":\"P51654\"},{\"label\":\"Glypican-4\",\"id\":\"O75487\"},{\"label\":\"Glypican-5\",\"id\":\"P78333\"},{\"label\":\"Glypican-6\",\"id\":\"Q9Y625\"},{\"label\":\"Heparanase\",\"id\":\"Q9Y251\"},{\"label\":\"Iduronate 2-sulfatase\",\"id\":\"P22304\"},{\"label\":\"Inactive heparanase-2\",\"id\":\"Q8WWQ2\"},{\"label\":\"N-sulphoglucosamine sulphohydrolase\",\"id\":\"P51688\"},{\"label\":\"Syndecan-1\",\"id\":\"P18827\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Syndecan-3\",\"id\":\"O75056\"},{\"label\":\"Syndecan-4\",\"id\":\"P31431\"}]", "uniprot_id": "[\"O00468\",\"O75056\",\"O75487\",\"P08236\",\"P16278\",\"P18827\",\"P22304\",\"P31431\",\"P34741\",\"P35052\",\"P35475\",\"P51654\",\"P51688\",\"P54802\",\"P78333\",\"P98160\",\"Q6UWU2\",\"Q8IW92\",\"Q8N158\",\"Q8NCI6\",\"Q8WWQ2\",\"Q9Y251\",\"Q9Y625\"]", "gene_symbol": "[\"AGRIN\",\"AGRN\",\"ELNR1\",\"GLB1\",\"GLB1L\",\"GLB1L2\",\"GLB1L3\",\"GPC1\",\"GPC2\",\"GPC3\",\"GPC4\",\"GPC5\",\"GPC6\",\"GUSB\",\"HEP\",\"HPA\",\"HPA1\",\"HPA2\",\"HPR1\",\"HPSE\",\"HPSE1\",\"HPSE2\",\"HSE1\",\"HSPG1\",\"HSPG2\",\"HSS\",\"IDS\",\"IDUA\",\"KIAA0468\",\"NAGLU\",\"OCI5\",\"SDC\",\"SDC1\",\"SDC2\",\"SDC3\",\"SDC4\",\"SGSH\",\"SIDS\",\"UFHSD1\"]", "gtc_id": "[\"G01550VL\",\"G09546QO\"]" }, { "pathway_label": "GRB2 events in ERBB2 signaling", "protein_name": 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p53\",\"id\":\"P04637\"},{\"label\":\"Checkpoint protein HUS1\",\"id\":\"O60921\"},{\"label\":\"Cyclin-A1\",\"id\":\"P78396\"},{\"label\":\"Cyclin-A2\",\"id\":\"P20248\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase 5 activator 1\",\"id\":\"Q15078\"},{\"label\":\"Cyclin-dependent kinase 5\",\"id\":\"Q00535\"},{\"label\":\"DNA endonuclease RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA replication ATP-dependent helicase/nuclease DNA2\",\"id\":\"P51530\"},{\"label\":\"DNA topoisomerase 2-binding protein 1\",\"id\":\"Q92547\"},{\"label\":\"DNA topoisomerase 3-alpha\",\"id\":\"Q13472\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Dual specificity tyrosine-phosphorylation-regulated kinase 2\",\"id\":\"Q92630\"},{\"label\":\"E3 ubiquitin-protein ligase Mdm2\",\"id\":\"Q00987\"},{\"label\":\"EKC/KEOPS complex subunit 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mitochondrial\",\"id\":\"Q9H8M1\"},{\"label\":\"Cytochrome c oxidase assembly factor 1 homolog\",\"id\":\"Q9GZY4\"},{\"label\":\"Cytochrome c oxidase assembly factor 3 homolog, mitochondrial\",\"id\":\"Q9Y2R0\"},{\"label\":\"Cytochrome c oxidase assembly factor 5\",\"id\":\"Q86WW8\"},{\"label\":\"Cytochrome c oxidase assembly protein COX11, mitochondrial\",\"id\":\"Q9Y6N1\"},{\"label\":\"Cytochrome c oxidase assembly protein COX14\",\"id\":\"Q96I36\"},{\"label\":\"Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial\",\"id\":\"Q9P0S2\"},{\"label\":\"Cytochrome c oxidase assembly protein COX18, mitochondrial\",\"id\":\"Q8N8Q8\"},{\"label\":\"Cytochrome c oxidase assembly protein COX19\",\"id\":\"Q49B96\"},{\"label\":\"Cytochrome c oxidase assembly protein COX20, mitochondrial\",\"id\":\"Q5RI15\"},{\"label\":\"Cytochrome c oxidase copper chaperone\",\"id\":\"Q14061\"},{\"label\":\"Cytochrome c oxidase subunit 1\",\"id\":\"P00395\"},{\"label\":\"Cytochrome c oxidase subunit 2\",\"id\":\"P00403\"},{\"label\":\"Cytochrome c oxidase subunit 3\",\"id\":\"P00414\"},{\"label\":\"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial\",\"id\":\"P13073\"},{\"label\":\"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial\",\"id\":\"Q96KJ9\"},{\"label\":\"Cytochrome c oxidase subunit 5A, mitochondrial\",\"id\":\"P20674\"},{\"label\":\"Cytochrome c oxidase subunit 5B, mitochondrial\",\"id\":\"P10606\"},{\"label\":\"Cytochrome c oxidase subunit 6A1, mitochondrial\",\"id\":\"P12074\"},{\"label\":\"Cytochrome c oxidase subunit 6A2, mitochondrial\",\"id\":\"Q02221\"},{\"label\":\"Cytochrome c oxidase subunit 6B1\",\"id\":\"P14854\"},{\"label\":\"Cytochrome c oxidase subunit 6B2\",\"id\":\"Q6YFQ2\"},{\"label\":\"Cytochrome c oxidase subunit 6C\",\"id\":\"P09669\"},{\"label\":\"Cytochrome c oxidase subunit 7A-related protein, mitochondrial\",\"id\":\"O14548\"},{\"label\":\"Cytochrome c oxidase subunit 7A1, mitochondrial\",\"id\":\"P24310\"},{\"label\":\"Cytochrome c oxidase subunit 7A2, mitochondrial\",\"id\":\"P14406\"},{\"label\":\"Cytochrome c oxidase subunit 7B, mitochondrial\",\"id\":\"P24311\"},{\"label\":\"Cytochrome c oxidase subunit 7C, mitochondrial\",\"id\":\"P15954\"},{\"label\":\"Cytochrome c oxidase subunit 8A, mitochondrial\",\"id\":\"P10176\"},{\"label\":\"Cytochrome c oxidase subunit 8C, mitochondrial\",\"id\":\"Q7Z4L0\"},{\"label\":\"Cytochrome c oxidase subunit NDUFA4\",\"id\":\"O00483\"},{\"label\":\"GEL complex subunit OPTI\",\"id\":\"Q9BUV8\"},{\"label\":\"HIG1 domain family member 1A, mitochondrial\",\"id\":\"Q9Y241\"},{\"label\":\"HIG1 domain family member 2A, mitochondrial\",\"id\":\"Q9BW72\"},{\"label\":\"Heme A synthase COX15\",\"id\":\"Q7KZN9\"},{\"label\":\"Mitochondrial import inner membrane translocase subunit Tim21\",\"id\":\"Q9BVV7\"},{\"label\":\"Protein PET100 homolog, mitochondrial\",\"id\":\"P0DJ07\"},{\"label\":\"Protein PET117 homolog, mitochondrial\",\"id\":\"Q6UWS5\"},{\"label\":\"Protein SCO1 homolog, mitochondrial\",\"id\":\"O75880\"},{\"label\":\"Protein SCO2 homolog, mitochondrial\",\"id\":\"O43819\"},{\"label\":\"Small integral membrane protein 20\",\"id\":\"Q8N5G0\"},{\"label\":\"Surfeit locus protein 1\",\"id\":\"Q15526\"},{\"label\":\"Translational activator of cytochrome c oxidase 1\",\"id\":\"Q9BSH4\"},{\"label\":\"Transmembrane protein 177\",\"id\":\"Q53S58\"},{\"label\":\"Transmembrane protein 223\",\"id\":\"A0PJW6\"}]", "uniprot_id": "[\"A0PJW6\",\"O00483\",\"O14548\",\"O43819\",\"O75880\",\"P00395\",\"P00403\",\"P00414\",\"P09669\",\"P0DJ07\",\"P10176\",\"P10606\",\"P12074\",\"P13073\",\"P14406\",\"P14854\",\"P15954\",\"P20674\",\"P24310\",\"P24311\",\"Q02221\",\"Q14061\",\"Q15526\",\"Q49B96\",\"Q53S58\",\"Q5RI15\",\"Q6UWS5\",\"Q6YFQ2\",\"Q7KZN9\",\"Q7Z4L0\",\"Q7Z7K0\",\"Q86WW8\",\"Q8N5G0\",\"Q8N8Q8\",\"Q96I36\",\"Q96KJ9\",\"Q96MF6\",\"Q9BSH4\",\"Q9BUV8\",\"Q9BVV7\",\"Q9BW72\",\"Q9GZY4\",\"Q9H8M1\",\"Q9P0S2\",\"Q9Y241\",\"Q9Y2R0\",\"Q9Y6N1\"]", "gene_symbol": "[\"C12orf62\",\"C14orf112\",\"C18orf55\",\"C19orf79\",\"C20orf24\",\"C2orf64\",\"C3orf68\",\"C4orf52\",\"C7orf44\",\"CCDC44\",\"CCDC56\",\"CMC1\",\"COA1\",\"COA3\",\"COA5\",\"COI\",\"COII\",\"COIII\",\"COQ10A\",\"COQ10B\",\"COX11\",\"COX14\",\"COX15\",\"COX16\",\"COX17\",\"COX18\",\"COX19\",\"COX2\",\"COX20\",\"COX4\",\"COX4I1\",\"COX4I2\",\"COX4L2\",\"COX5A\",\"COX5B\",\"COX6A\",\"COX6A1\",\"COX6A2\",\"COX6AH\",\"COX6AL\",\"COX6B\",\"COX6B1\",\"COX6B2\",\"COX6C\",\"COX7A1\",\"COX7A2\",\"COX7A2L\",\"COX7AH\",\"COX7AL\",\"COX7AR\",\"COX7B\",\"COX7C\",\"COX7RP\",\"COX8\",\"COX8A\",\"COX8C\",\"COX8L\",\"COXI\",\"COXII\",\"COXIII\",\"FAM36A\",\"HIG1\",\"HIGD1A\",\"HIGD2A\",\"MITRAC12\",\"MITRAC15\",\"MITRAC7\",\"MT-CO1\",\"MT-CO2\",\"MT-CO3\",\"MTCO1\",\"MTCO2\",\"MTCO3\",\"NDUFA4\",\"OPTI\",\"OXA1L2\",\"PET100\",\"PET117\",\"RAB5IF\",\"RCAF1\",\"SCO1\",\"SCO2\",\"SCOD1\",\"SMIM20\",\"SURF-1\",\"SURF1\",\"TACO1\",\"TIM21\",\"TIMM21\",\"TMEM177\",\"TMEM223\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PKMTs methylate histone lysines", "protein_name": "[{\"label\":\"Actin-histidine N-methyltransferase\",\"id\":\"Q86TU7\"},{\"label\":\"Activating transcription factor 7-interacting protein 1\",\"id\":\"Q6VMQ6\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Histone-binding protein RBBP7\",\"id\":\"Q16576\"},{\"label\":\"Histone-lysine N-methyltransferase 2A\",\"id\":\"Q03164\"},{\"label\":\"Histone-lysine N-methyltransferase 2B\",\"id\":\"Q9UMN6\"},{\"label\":\"Histone-lysine N-methyltransferase 2C\",\"id\":\"Q8NEZ4\"},{\"label\":\"Histone-lysine N-methyltransferase 2D\",\"id\":\"O14686\"},{\"label\":\"Histone-lysine N-methyltransferase ASH1L\",\"id\":\"Q9NR48\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT1\",\"id\":\"Q9H9B1\"},{\"label\":\"Histone-lysine N-methyltransferase EHMT2\",\"id\":\"Q96KQ7\"},{\"label\":\"Histone-lysine N-methyltransferase EZH2\",\"id\":\"Q15910\"},{\"label\":\"Histone-lysine N-methyltransferase KMT5B\",\"id\":\"Q4FZB7\"},{\"label\":\"Histone-lysine N-methyltransferase KMT5C\",\"id\":\"Q86Y97\"},{\"label\":\"Histone-lysine N-methyltransferase MECOM\",\"id\":\"Q03112\"},{\"label\":\"Histone-lysine N-methyltransferase NSD2\",\"id\":\"O96028\"},{\"label\":\"Histone-lysine N-methyltransferase NSD3\",\"id\":\"Q9BZ95\"},{\"label\":\"Histone-lysine N-methyltransferase PRDM16\",\"id\":\"Q9HAZ2\"},{\"label\":\"Histone-lysine N-methyltransferase PRDM9\",\"id\":\"Q9NQV7\"},{\"label\":\"Histone-lysine N-methyltransferase SETD1A\",\"id\":\"O15047\"},{\"label\":\"Histone-lysine N-methyltransferase SETD1B\",\"id\":\"Q9UPS6\"},{\"label\":\"Histone-lysine N-methyltransferase SETD2\",\"id\":\"Q9BYW2\"},{\"label\":\"Histone-lysine N-methyltransferase SETD7\",\"id\":\"Q8WTS6\"},{\"label\":\"Histone-lysine N-methyltransferase SETDB1\",\"id\":\"Q15047\"},{\"label\":\"Histone-lysine N-methyltransferase SETDB2\",\"id\":\"Q96T68\"},{\"label\":\"Histone-lysine N-methyltransferase SMYD3\",\"id\":\"Q9H7B4\"},{\"label\":\"Histone-lysine N-methyltransferase SUV39H1\",\"id\":\"O43463\"},{\"label\":\"Histone-lysine N-methyltransferase SUV39H2\",\"id\":\"Q9H5I1\"},{\"label\":\"Histone-lysine N-methyltransferase, H3 lysine-36 specific\",\"id\":\"Q96L73\"},{\"label\":\"Histone-lysine N-methyltransferase, H3 lysine-79 specific\",\"id\":\"Q8TEK3\"},{\"label\":\"N-lysine methyltransferase KMT5A\",\"id\":\"Q9NQR1\"},{\"label\":\"N-lysine methyltransferase SETD6\",\"id\":\"Q8TBK2\"},{\"label\":\"N-lysine methyltransferase SMYD2\",\"id\":\"Q9NRG4\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Polycomb protein EED\",\"id\":\"O75530\"},{\"label\":\"Polycomb protein SUZ12\",\"id\":\"Q15022\"},{\"label\":\"Protein dpy-30 homolog\",\"id\":\"Q9C005\"},{\"label\":\"Retinoblastoma-binding protein 5\",\"id\":\"Q15291\"},{\"label\":\"Set1/Ash2 histone methyltransferase complex subunit ASH2\",\"id\":\"Q9UBL3\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"},{\"label\":\"WD repeat-containing protein 5\",\"id\":\"P61964\"},{\"label\":\"Zinc finger protein AEBP2\",\"id\":\"Q6ZN18\"}]", "uniprot_id": "[\"O14686\",\"O15047\",\"O43463\",\"O75530\",\"O96028\",\"P19838\",\"P61964\",\"P62805\",\"P68431\",\"Q00653\",\"Q03112\",\"Q03164\",\"Q04206\",\"Q09028\",\"Q15022\",\"Q15047\",\"Q15291\",\"Q15910\",\"Q16576\",\"Q4FZB7\",\"Q6VMQ6\",\"Q6ZN18\",\"Q71DI3\",\"Q86TU7\",\"Q86Y97\",\"Q8NEZ4\",\"Q8TBK2\",\"Q8TEK3\",\"Q8WTS6\",\"Q96KQ7\",\"Q96L73\",\"Q96T68\",\"Q9BYW2\",\"Q9BZ95\",\"Q9C005\",\"Q9H5I1\",\"Q9H7B4\",\"Q9H9B1\",\"Q9HAZ2\",\"Q9NQR1\",\"Q9NQV7\",\"Q9NR48\",\"Q9NRG4\",\"Q9UBL3\",\"Q9UMN6\",\"Q9UPS6\"]", "gene_symbol": "[\"AEBP2\",\"ALL1\",\"ALR\",\"ARA267\",\"ASH1L\",\"ASH2L\",\"ASH2L1\",\"ATF7IP\",\"BAT8\",\"BIG3\",\"C13orf4\",\"C14orf154\",\"C6orf30\",\"CHET9\",\"CLLD8\",\"CXXC7\",\"DOT1L\",\"DPY30\",\"EED\",\"EHMT1\",\"EHMT2\",\"ESET\",\"EUHMTASE1\",\"EVI1\",\"EZH2\",\"G9A\",\"GLP\",\"H3C1\",\"H3C10\",\"H3C11\",\"H3C12\",\"H3C13\",\"H3C14\",\"H3C15\",\"H3C2\",\"H3C3\",\"H3C4\",\"H3C6\",\"H3C7\",\"H3C8\",\"H3F2\",\"H3FA\",\"H3FB\",\"H3FC HIST1H3C\",\"H3FD\",\"H3FF\",\"H3FH\",\"H3FI\",\"H3FJ\",\"H3FK\",\"H3FL\",\"H3FM\",\"H4-16\",\"H4/A\",\"H4/B\",\"H4/C\",\"H4/D\",\"H4/E\",\"H4/G\",\"H4/H\",\"H4/I\",\"H4/J\",\"H4/K\",\"H4/M\",\"H4/N\",\"H4/O\",\"H4C1\",\"H4C11\",\"H4C12\",\"H4C13\",\"H4C14\",\"H4C15\",\"H4C16\",\"H4C2\",\"H4C3\",\"H4C4\",\"H4C5\",\"H4C6\",\"H4C8\",\"H4C9\",\"H4F2\",\"H4FA\",\"H4FB\",\"H4FC\",\"H4FD\",\"H4FE\",\"H4FG\",\"H4FH\",\"H4FI\",\"H4FJ\",\"H4FK\",\"H4FM\",\"H4FN\",\"H4FO\",\"HALR\",\"HIF1\",\"HIST1H3A\",\"HIST1H3B\",\"HIST1H3D\",\"HIST1H3E\",\"HIST1H3F\",\"HIST1H3G\",\"HIST1H3H\",\"HIST1H3I\",\"HIST1H3J\",\"HIST1H4A\",\"HIST1H4B\",\"HIST1H4C\",\"HIST1H4D\",\"HIST1H4E\",\"HIST1H4F\",\"HIST1H4H\",\"HIST1H4I\",\"HIST1H4J\",\"HIST1H4K\",\"HIST1H4L\",\"HIST2H3A\",\"HIST2H3C\",\"HIST2H3D\",\"HIST2H4\",\"HIST2H4A\",\"HIST2H4B\",\"HIST4H4\",\"HRX\",\"HRX2\",\"HTRX\",\"HYPB\",\"JJAZ1\",\"KIAA0067\",\"KIAA0160\",\"KIAA0304\",\"KIAA0339\",\"KIAA1076\",\"KIAA1090\",\"KIAA1420\",\"KIAA1506\",\"KIAA1675\",\"KIAA1717\",\"KIAA1732\",\"KIAA1814\",\"KIAA1876\",\"KMT1A\",\"KMT1B\",\"KMT1C\",\"KMT1D\",\"KMT1E\",\"KMT1F\",\"KMT2A\",\"KMT2B\",\"KMT2C\",\"KMT2D\",\"KMT2F\",\"KMT2G\",\"KMT2H\",\"KMT3A\",\"KMT3B\",\"KMT3C\",\"KMT4\",\"KMT5A\",\"KMT5B\",\"KMT5C\",\"KMT6\",\"KMT7\",\"LYT10\",\"MCAF\",\"MCAF1\",\"MDS1\",\"MECOM\",\"MEL1\",\"MLL\",\"MLL1\",\"MLL2\",\"MLL3\",\"MLL4\",\"MMSET\",\"NFKB1\",\"NFKB2\",\"NFKB3\",\"NG36\",\"NSD1\",\"NSD2\",\"NSD3\",\"PFM13\",\"PFM6\",\"PRDM16\",\"PRDM3\",\"PRDM9\",\"PRSET7\",\"RBAP46\",\"RBAP48\",\"RBBP4\",\"RBBP5\",\"RBBP7\",\"RBQ3\",\"RELA\",\"SET07\",\"SET1\",\"SET1A\",\"SET1B\",\"SET2\",\"SET7\",\"SET8\",\"SET9\",\"SETD1A\",\"SETD1B\",\"SETD2\",\"SETD3\",\"SETD6\",\"SETD7\",\"SETD8\",\"SETDB1\",\"SETDB2\",\"SMYD2\",\"SMYD3\",\"SUV39H\",\"SUV39H1\",\"SUV39H2\",\"SUV420H1\",\"SUV420H2\",\"SUZ12\",\"TRX1\",\"TRX2\",\"TRX5\",\"WBP7\",\"WDR5\",\"WHSC1\",\"WHSC1L1\",\"ZMYND1\",\"ZNFN3A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Vif-mediated degradation of APOBEC3G", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Cullin-5\",\"id\":\"Q93034\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"O00231\",\"O00232\",\"O00487\",\"O14818\",\"O43242\",\"P0CG47\",\"P0CG48\",\"P17980\",\"P20618\",\"P25786\",\"P25787\",\"P25788\",\"P25789\",\"P28066\",\"P28070\",\"P28072\",\"P28074\",\"P35998\",\"P43686\",\"P48556\",\"P49720\",\"P49721\",\"P51665\",\"P60896\",\"P60900\",\"P62191\",\"P62195\",\"P62333\",\"P62877\",\"P62979\",\"P62987\",\"P69723\",\"Q13200\",\"Q15008\",\"Q15369\",\"Q15370\",\"Q16186\",\"Q93034\",\"Q99436\",\"Q99460\",\"Q9UNM6\"]", "gene_symbol": "[\"ADRM1\",\"C7orf76\",\"CUL5\",\"DSS1\",\"ELOB\",\"ELOC\",\"GP110\",\"HC2\",\"HC3\",\"HC8\",\"HC9\",\"HSPC\",\"KIAA0107\",\"LMPX\",\"LMPY\",\"MB1\",\"MIP224\",\"MOV34L\",\"MSS1\",\"NU\",\"PFAAP4\",\"POH1\",\"PROS26\",\"PROS27\",\"PROS30\",\"PSC2\",\"PSC3\",\"PSC5\",\"PSC8\",\"PSC9\",\"PSMA1\",\"PSMA2\",\"PSMA3\",\"PSMA4\",\"PSMA5\",\"PSMA6\",\"PSMA7\",\"PSMB1\",\"PSMB2\",\"PSMB3\",\"PSMB4\",\"PSMB5\",\"PSMB6\",\"PSMB7\",\"PSMC1\",\"PSMC2\",\"PSMC3\",\"PSMC4\",\"PSMC5\",\"PSMC6\",\"PSMD1\",\"PSMD11\",\"PSMD12\",\"PSMD13\",\"PSMD14\",\"PSMD2\",\"PSMD3\",\"PSMD6\",\"PSMD7\",\"PSMD8\",\"RBX1\",\"RNF75\",\"ROC1\",\"RPS27A\",\"SEM1\",\"SHFDG1\",\"SHFM1\",\"SUG1\",\"SUG2\",\"TBP1\",\"TBP7\",\"TCEB1\",\"TCEB2\",\"TRAP2\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"VACM1\",\"X\",\"Y\",\"Z\",\"vif\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FCGR activation", "protein_name": "[{\"label\":\"High affinity immunoglobulin gamma Fc receptor I\",\"id\":\"P12314\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant gamma 1\",\"id\":\"P01857\"},{\"label\":\"Immunoglobulin heavy constant gamma 2\",\"id\":\"P01859\"},{\"label\":\"Immunoglobulin heavy constant gamma 3\",\"id\":\"P01860\"},{\"label\":\"Immunoglobulin heavy constant gamma 4\",\"id\":\"P01861\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 3-20\",\"id\":\"P01619\"},{\"label\":\"Immunoglobulin kappa variable 3D-20\",\"id\":\"A0A0C4DH25\"},{\"label\":\"Immunoglobulin kappa variable 4-1\",\"id\":\"P06312\"},{\"label\":\"Immunoglobulin kappa variable 5-2\",\"id\":\"P06315\"},{\"label\":\"Immunoglobulin lambda constant 1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 3\",\"id\":\"P0DOY3\"},{\"label\":\"Immunoglobulin lambda constant 6\",\"id\":\"P0CF74\"},{\"label\":\"Immunoglobulin lambda constant 7\",\"id\":\"A0M8Q6\"},{\"label\":\"Immunoglobulin lambda variable 1-40\",\"id\":\"P01703\"},{\"label\":\"Immunoglobulin lambda variable 1-44\",\"id\":\"P01699\"},{\"label\":\"Immunoglobulin lambda variable 1-47\",\"id\":\"P01700\"},{\"label\":\"Immunoglobulin lambda variable 1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 2-8\",\"id\":\"P01709\"},{\"label\":\"Immunoglobulin lambda variable 3-19\",\"id\":\"P01714\"},{\"label\":\"Immunoglobulin lambda variable 3-1\",\"id\":\"P01715\"},{\"label\":\"Immunoglobulin lambda variable 3-21\",\"id\":\"P80748\"},{\"label\":\"Immunoglobulin lambda variable 3-25\",\"id\":\"P01717\"},{\"label\":\"Immunoglobulin lambda variable 3-27\",\"id\":\"P01718\"},{\"label\":\"Immunoglobulin lambda variable 6-57\",\"id\":\"P01721\"},{\"label\":\"Immunoglobulin lambda variable 7-43\",\"id\":\"P04211\"},{\"label\":\"Immunolglobulin kappa light chain variable region L22 (Fragment)\",\"id\":\"A2NXD2\"},{\"label\":\"Low affinity immunoglobulin gamma Fc region receptor II-a\",\"id\":\"P12318\"},{\"label\":\"Low affinity immunoglobulin gamma Fc region receptor III-A\",\"id\":\"P08637\"},{\"label\":\"T-cell surface glycoprotein CD3 gamma 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1\",\"id\":\"P54274\"},{\"label\":\"Telomeric repeat-binding factor 2-interacting protein 1\",\"id\":\"Q9NYB0\"},{\"label\":\"Telomeric repeat-binding factor 2\",\"id\":\"Q15554\"}]", "uniprot_id": "[\"O15527\",\"O60814\",\"P04908\",\"P06899\",\"P0C5Y9\",\"P16104\",\"P20671\",\"P23527\",\"P29372\",\"P33778\",\"P54274\",\"P57053\",\"P58876\",\"P62805\",\"P62807\",\"Q15554\",\"Q16695\",\"Q16777\",\"Q16778\",\"Q6FI13\",\"Q71UI9\",\"Q8N257\",\"Q8TAT5\",\"Q93077\",\"Q93079\",\"Q96A08\",\"Q96AP0\",\"Q99877\",\"Q99878\",\"Q99879\",\"Q99880\",\"Q9BSI4\",\"Q9BTM1\",\"Q9NUX5\",\"Q9NYB0\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of RUNX1 Expression and Activity", "protein_name": "[{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"Cyclin-dependent kinase 6\",\"id\":\"Q00534\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"G1/S-specific cyclin-D2\",\"id\":\"P30279\"},{\"label\":\"G1/S-specific cyclin-D3\",\"id\":\"P30281\"},{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Protein PML\",\"id\":\"P29590\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein argonaute-3\",\"id\":\"Q9H9G7\"},{\"label\":\"Protein argonaute-4\",\"id\":\"Q9HCK5\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"},{\"label\":\"Trinucleotide repeat-containing gene 6A protein\",\"id\":\"Q8NDV7\"},{\"label\":\"Trinucleotide repeat-containing gene 6B protein\",\"id\":\"Q9UPQ9\"},{\"label\":\"Trinucleotide repeat-containing gene 6C protein\",\"id\":\"Q9HCJ0\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"P12931\",\"P24385\",\"P29590\",\"P30279\",\"P30281\",\"Q00534\",\"Q01196\",\"Q06124\",\"Q13951\",\"Q8NDV7\",\"Q9H9G7\",\"Q9HCE1\",\"Q9HCJ0\",\"Q9HCK5\",\"Q9UKV8\",\"Q9UL18\",\"Q9UPQ9\"]", "gene_symbol": "[\"AGO1\",\"AGO2\",\"AGO3\",\"AGO4\",\"AML1\",\"BCL1\",\"CAGH26\",\"CBFA2\",\"CBFB\",\"CCND1\",\"CCND2\",\"CCND3\",\"CDK6\",\"CDKN6\",\"EIF2C1\",\"EIF2C2\",\"EIF2C3\",\"EIF2C4\",\"KIAA1093\",\"KIAA1460\",\"KIAA1567\",\"KIAA1582\",\"KIAA1631\",\"MOV10\",\"MYL\",\"PML\",\"PP8675\",\"PRAD1\",\"PTP2C\",\"PTPN11\",\"RNF71\",\"RUNX1\",\"SHPTP2\",\"SRC\",\"SRC1\",\"TNRC6\",\"TNRC6A\",\"TNRC6B\",\"TNRC6C\",\"TRIM19\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Lipophagy", "protein_name": "[{\"label\":\"5'-AMP-activated protein kinase catalytic subunit alpha-2\",\"id\":\"P54646\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-1\",\"id\":\"Q9Y478\"},{\"label\":\"5'-AMP-activated protein kinase subunit beta-2\",\"id\":\"O43741\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-1\",\"id\":\"P54619\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-2\",\"id\":\"Q9UGJ0\"},{\"label\":\"5'-AMP-activated protein kinase subunit gamma-3\",\"id\":\"Q9UGI9\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Perilipin-2\",\"id\":\"Q99541\"},{\"label\":\"Perilipin-3\",\"id\":\"O60664\"}]", "uniprot_id": "[\"O43741\",\"O60664\",\"P11142\",\"P54619\",\"P54646\",\"Q99541\",\"Q9UGI9\",\"Q9UGJ0\",\"Q9Y478\"]", "gene_symbol": "[\"ADFP\",\"AMPK\",\"AMPK2\",\"AMPKG3\",\"HSC70\",\"HSP73\",\"HSPA10\",\"HSPA8\",\"M6PRBP1\",\"PLIN2\",\"PLIN3\",\"PRKAA2\",\"PRKAB1\",\"PRKAB2\",\"PRKAG1\",\"PRKAG2\",\"PRKAG3\",\"TIP47\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by RAF1 mutants", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein\",\"id\":\"Q7Z5R6\"},{\"label\":\"Beta-arrestin-1\",\"id\":\"P49407\"},{\"label\":\"Beta-arrestin-2\",\"id\":\"P32121\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Connector enhancer of kinase suppressor of ras 1\",\"id\":\"Q969H4\"},{\"label\":\"Connector enhancer of kinase suppressor of ras 2\",\"id\":\"Q8WXI2\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 1\",\"id\":\"Q02750\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 2\",\"id\":\"P36507\"},{\"label\":\"Fibrinogen alpha chain\",\"id\":\"P02671\"},{\"label\":\"Fibrinogen beta chain\",\"id\":\"P02675\"},{\"label\":\"Fibrinogen gamma chain\",\"id\":\"P02679\"},{\"label\":\"Fibronectin\",\"id\":\"P02751\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Integrin alpha-IIb\",\"id\":\"P08514\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Kinase suppressor of Ras 1\",\"id\":\"Q8IVT5\"},{\"label\":\"Kinase suppressor of Ras 2\",\"id\":\"Q6VAB6\"},{\"label\":\"MAP/microtubule affinity-regulating kinase 3\",\"id\":\"P27448\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP1\",\"id\":\"P46940\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"},{\"label\":\"Serine/threonine-protein kinase A-Raf\",\"id\":\"P10398\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"},{\"label\":\"Talin-1\",\"id\":\"Q9Y490\"},{\"label\":\"Tyrosine-protein kinase CSK\",\"id\":\"P41240\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Vinculin\",\"id\":\"P18206\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": 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receptor Kit\",\"id\":\"P10721\"}]", "uniprot_id": "[\"P10721\"]", "gene_symbol": "[\"KIT\",\"SCFR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-6 signaling", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase CBL\",\"id\":\"P22681\"},{\"label\":\"Interleukin-6 receptor subunit alpha\",\"id\":\"P08887\"},{\"label\":\"Interleukin-6 receptor subunit beta\",\"id\":\"P40189\"},{\"label\":\"Interleukin-6\",\"id\":\"P05231\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Suppressor of cytokine signaling 3\",\"id\":\"O14543\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": 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secretory phospholipase A2\",\"id\":\"Q9BZM2\"},{\"label\":\"Group XIIA secretory phospholipase A2\",\"id\":\"Q9BZM1\"},{\"label\":\"Lysophospholipid acyltransferase 1\",\"id\":\"Q6ZNC8\"},{\"label\":\"Lysophospholipid acyltransferase 5\",\"id\":\"Q6P1A2\"},{\"label\":\"Lysophospholipid acyltransferase LPCAT4\",\"id\":\"Q643R3\"},{\"label\":\"Oxysterol-binding protein-related protein 10\",\"id\":\"Q9BXB5\"},{\"label\":\"Oxysterol-binding protein-related protein 5\",\"id\":\"Q9H0X9\"},{\"label\":\"Oxysterol-binding protein-related protein 8\",\"id\":\"Q9BZF1\"},{\"label\":\"Phospholipase A and acyltransferase 3\",\"id\":\"P53816\"},{\"label\":\"Phospholipase A1 member A\",\"id\":\"Q53H76\"},{\"label\":\"Phospholipase A2 group V\",\"id\":\"P39877\"},{\"label\":\"Phospholipase A2, membrane associated\",\"id\":\"P14555\"},{\"label\":\"Phospholipase A2\",\"id\":\"P04054\"},{\"label\":\"Secretory phospholipase A2 receptor\",\"id\":\"Q13018\"}]", "uniprot_id": 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4\",\"id\":\"P02776\"},{\"label\":\"Proteinase-activated receptor 1\",\"id\":\"P25116\"},{\"label\":\"Prothrombin\",\"id\":\"P00734\"},{\"label\":\"Thrombomodulin\",\"id\":\"P07204\"},{\"label\":\"Vitamin K-dependent protein C\",\"id\":\"P04070\"},{\"label\":\"Vitamin K-dependent protein S\",\"id\":\"P07225\"}]", "uniprot_id": "[\"P00451\",\"P00488\",\"P00734\",\"P00742\",\"P01008\",\"P02671\",\"P02675\",\"P02679\",\"P02776\",\"P04070\",\"P05154\",\"P05160\",\"P05546\",\"P07093\",\"P07204\",\"P07225\",\"P10720\",\"P12259\",\"P24158\",\"P25116\",\"Q8N6Q3\",\"Q9UNN8\"]", "gene_symbol": 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3\",\"id\":\"P58215\"},{\"label\":\"Lysyl oxidase homolog 4\",\"id\":\"Q96JB6\"},{\"label\":\"Peroxidasin homolog\",\"id\":\"Q92626\"},{\"label\":\"Procollagen C-endopeptidase enhancer 1\",\"id\":\"Q15113\"},{\"label\":\"Protein-lysine 6-oxidase\",\"id\":\"P28300\"},{\"label\":\"Tolloid-like protein 1\",\"id\":\"O43897\"},{\"label\":\"Tolloid-like protein 2\",\"id\":\"Q9Y6L7\"}]", "uniprot_id": "[\"O43897\",\"P13497\",\"P28300\",\"P58215\",\"Q08397\",\"Q15113\",\"Q92626\",\"Q96JB6\",\"Q9Y4K0\",\"Q9Y6L7\"]", "gene_symbol": "[\"BMP1\",\"KIAA0230\",\"KIAA0932\",\"LOX\",\"LOXC\",\"LOXL\",\"LOXL1\",\"LOXL2\",\"LOXL3\",\"LOXL4\",\"MG50\",\"PCOLC\",\"PCOLCE\",\"PCPE1\",\"PRG2\",\"PXD01\",\"PXDN\",\"TLL\",\"TLL1\",\"TLL2\",\"VPO\",\"VPO1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NFE2L2 regulating anti-oxidant/detoxification enzymes", "protein_name": "[{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Cyclic AMP-dependent transcription factor 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MafK\",\"id\":\"O60675\"},{\"label\":\"Transcription regulator protein BACH1\",\"id\":\"O14867\"}]", "uniprot_id": "[\"O14867\",\"O60675\",\"P08263\",\"P08294\",\"P09601\",\"P10599\",\"P15559\",\"P18848\",\"P48506\",\"P48507\",\"Q06830\",\"Q09472\",\"Q16236\",\"Q16772\",\"Q16881\",\"Q92793\",\"Q9BYN0\",\"Q9UPY5\"]", "gene_symbol": "[\"ATF4\",\"BACH1\",\"C20orf139\",\"CBP\",\"CREB2\",\"CREBBP\",\"DIA4\",\"EP300\",\"GCLC\",\"GCLM\",\"GLCL\",\"GLCLC\",\"GLCLR\",\"GRIM12\",\"GSTA1\",\"GSTA3\",\"HMOX1\",\"HO\",\"HO1\",\"KDRF\",\"MAFK\",\"NFE2L2\",\"NMOR1\",\"NQO1\",\"NRF2\",\"P300\",\"PAGA\",\"PAGB\",\"PRDX1\",\"SLC7A11\",\"SOD3\",\"SRX\",\"SRX1\",\"SRXN1\",\"TDPX2\",\"TRDX\",\"TRX\",\"TRX1\",\"TXN\",\"TXNRD1\",\"TXREB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Maturation of hRSV A proteins", "protein_name": "[{\"label\":\"Casein kinase II subunit alpha'\",\"id\":\"P19784\"},{\"label\":\"Casein kinase II subunit alpha\",\"id\":\"P68400\"},{\"label\":\"Casein kinase II subunit 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peptidase complex catalytic subunit SEC11C\",\"id\":\"Q9BY50\"},{\"label\":\"Signal peptidase complex subunit 1\",\"id\":\"Q9Y6A9\"},{\"label\":\"Signal peptidase complex subunit 2\",\"id\":\"Q15005\"},{\"label\":\"Signal peptidase complex subunit 3\",\"id\":\"P61009\"}]", "uniprot_id": "[\"O14980\",\"P03418\",\"P03420\",\"P03421\",\"P04543\",\"P04545\",\"P09958\",\"P0DOE7\",\"P0DOE9\",\"P19784\",\"P28887\",\"P36873\",\"P61009\",\"P62136\",\"P62140\",\"P67812\",\"P67870\",\"P68400\",\"P70168\",\"Q15005\",\"Q9BY50\",\"Q9Y6A9\"]", "gene_symbol": "[\"1B\",\"1C\",\"CK2A1\",\"CK2A2\",\"CK2N\",\"CRM1\",\"CSNK2A1\",\"CSNK2A2\",\"CSNK2B\",\"F\",\"FUR\",\"FURIN\",\"G5A\",\"Impnb\",\"KIAA0102\",\"Kpnb1\",\"L\",\"M\",\"M2-1\",\"N\",\"NS1\",\"NS2\",\"P\",\"PACE\",\"PCSK3\",\"PPP1A\",\"PPP1CA\",\"PPP1CB\",\"PPP1CC\",\"SEC11A\",\"SEC11C\",\"SEC11L1\",\"SEC11L3\",\"SPC12\",\"SPC18\",\"SPC21\",\"SPC22\",\"SPC25\",\"SPCS1\",\"SPCS2\",\"SPCS3\",\"SPCS4A\",\"SPCS4C\",\"XPO1\"]", "gtc_id": "[\"\"]" }, { 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective visual phototransduction due to STRA6 loss of function", "protein_name": "[{\"label\":\"Receptor for retinol uptake STRA6\",\"id\":\"Q9BX79\"},{\"label\":\"Retinol-binding protein 4\",\"id\":\"P02753\"},{\"label\":\"Transthyretin\",\"id\":\"P02766\"}]", "uniprot_id": "[\"P02753\",\"P02766\",\"Q9BX79\"]", "gene_symbol": "[\"PALB\",\"RBP4\",\"STRA6\",\"TTR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RHO GTPases activate PAKs", "protein_name": "[{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Filamin-A\",\"id\":\"P21333\"},{\"label\":\"LIM domain kinase 1\",\"id\":\"P53667\"},{\"label\":\"Merlin\",\"id\":\"P35240\"},{\"label\":\"Myosin light chain kinase, smooth muscle\",\"id\":\"Q15746\"},{\"label\":\"Myosin light polypeptide 6\",\"id\":\"P60660\"},{\"label\":\"Myosin regulatory light chain 12B\",\"id\":\"O14950\"},{\"label\":\"Myosin regulatory light polypeptide 9\",\"id\":\"P24844\"},{\"label\":\"Myosin-10\",\"id\":\"P35580\"},{\"label\":\"Myosin-11\",\"id\":\"P35749\"},{\"label\":\"Myosin-14\",\"id\":\"Q7Z406\"},{\"label\":\"Myosin-9\",\"id\":\"P35579\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 12A\",\"id\":\"O14974\"},{\"label\":\"Protein phosphatase 1 regulatory subunit 12B\",\"id\":\"O60237\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-beta catalytic subunit\",\"id\":\"P62140\"},{\"label\":\"Src substrate cortactin\",\"id\":\"Q14247\"}]", "uniprot_id": 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protein\",\"id\":\"O15503\"},{\"label\":\"Insulin-induced gene 2 protein\",\"id\":\"Q9Y5U4\"},{\"label\":\"Membrane-bound transcription factor site-1 protease\",\"id\":\"Q14703\"},{\"label\":\"Membrane-bound transcription factor site-2 protease\",\"id\":\"O43462\"},{\"label\":\"Protein transport protein Sec23A\",\"id\":\"Q15436\"},{\"label\":\"Protein transport protein Sec24A\",\"id\":\"O95486\"},{\"label\":\"Protein transport protein Sec24B\",\"id\":\"O95487\"},{\"label\":\"Protein transport protein Sec24C\",\"id\":\"P53992\"},{\"label\":\"Protein transport protein Sec24D\",\"id\":\"O94855\"},{\"label\":\"Small COPII coat GTPase SAR1B\",\"id\":\"Q9Y6B6\"},{\"label\":\"Sterol regulatory element-binding protein 2\",\"id\":\"Q12772\"},{\"label\":\"Sterol regulatory element-binding protein cleavage-activating protein\",\"id\":\"Q12770\"}]", "uniprot_id": 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"[\"O75496\",\"P25205\",\"P33991\",\"P33992\",\"P33993\",\"P49736\",\"Q14566\",\"Q9H211\"]", "gene_symbol": "[\"BM28\",\"CCNL1\",\"CDC21\",\"CDC46\",\"CDC47\",\"CDCL1\",\"CDT1\",\"GMNN\",\"KIAA0030\",\"MCM2\",\"MCM3\",\"MCM4\",\"MCM5\",\"MCM6\",\"MCM7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Neutrophil degranulation", "protein_name": "[{\"label\":\"1-acyl-sn-glycerol-3-phosphate acyltransferase beta\",\"id\":\"O15120\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"28 kDa heat- and acid-stable phosphoprotein\",\"id\":\"Q13442\"},{\"label\":\"3-ketoacyl-CoA thiolase, peroxisomal\",\"id\":\"P09110\"},{\"label\":\"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2\",\"id\":\"Q10588\"},{\"label\":\"ADP-ribosylation factor-like protein 8A\",\"id\":\"Q96BM9\"},{\"label\":\"AMP deaminase 3\",\"id\":\"Q01432\"},{\"label\":\"AP-1 complex subunit mu-1\",\"id\":\"Q9BXS5\"},{\"label\":\"AP-2 complex subunit alpha-2\",\"id\":\"O94973\"},{\"label\":\"ATP-binding cassette sub-family A member 13\",\"id\":\"Q86UQ4\"},{\"label\":\"ATP-citrate synthase\",\"id\":\"P53396\"},{\"label\":\"ATP-dependent 6-phosphofructokinase, liver type\",\"id\":\"P17858\"},{\"label\":\"ATP-dependent RNA helicase DDX3X\",\"id\":\"O00571\"},{\"label\":\"ATPase family AAA domain-containing protein 3B\",\"id\":\"Q5T9A4\"},{\"label\":\"Acid ceramidase\",\"id\":\"Q13510\"},{\"label\":\"Actin-related protein 10\",\"id\":\"Q9NZ32\"},{\"label\":\"Actin-related protein 2/3 complex subunit 5\",\"id\":\"O15511\"},{\"label\":\"Actin-related protein 2\",\"id\":\"P61160\"},{\"label\":\"Acylamino-acid-releasing enzyme\",\"id\":\"P13798\"},{\"label\":\"Adenine phosphoribosyltransferase\",\"id\":\"P07741\"},{\"label\":\"Adenosine deaminase 2\",\"id\":\"Q9NZK5\"},{\"label\":\"Adenylyl cyclase-associated protein 1\",\"id\":\"Q01518\"},{\"label\":\"Adhesion G protein-coupled receptor E3\",\"id\":\"Q9BY15\"},{\"label\":\"Adhesion G protein-coupled receptor E5\",\"id\":\"P48960\"},{\"label\":\"Adhesion G protein-coupled receptor G3\",\"id\":\"Q86Y34\"},{\"label\":\"Aldehyde dehydrogenase family 3 member 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39\",\"id\":\"Q9Y376\"},{\"label\":\"Calmodulin-like protein 5\",\"id\":\"Q9NZT1\"},{\"label\":\"Calpain-1 catalytic subunit\",\"id\":\"P07384\"},{\"label\":\"Calponin-2\",\"id\":\"Q99439\"},{\"label\":\"Carabin\",\"id\":\"Q8IV04\"},{\"label\":\"Carcinoembryonic antigen-related cell adhesion molecule 1\",\"id\":\"P13688\"},{\"label\":\"Carcinoembryonic antigen-related cell adhesion molecule 3\",\"id\":\"P40198\"},{\"label\":\"Carcinoembryonic antigen-related cell adhesion molecule 6\",\"id\":\"P40199\"},{\"label\":\"Carcinoembryonic antigen-related cell adhesion molecule 8\",\"id\":\"P31997\"},{\"label\":\"Casein kinase II subunit beta\",\"id\":\"P67870\"},{\"label\":\"Catalase\",\"id\":\"P04040\"},{\"label\":\"Cathelicidin antimicrobial peptide\",\"id\":\"P49913\"},{\"label\":\"Cathepsin B\",\"id\":\"P07858\"},{\"label\":\"Cathepsin D\",\"id\":\"P07339\"},{\"label\":\"Cathepsin G\",\"id\":\"P08311\"},{\"label\":\"Cathepsin S\",\"id\":\"P25774\"},{\"label\":\"Cathepsin Z\",\"id\":\"Q9UBR2\"},{\"label\":\"Cation-independent mannose-6-phosphate receptor\",\"id\":\"P11717\"},{\"label\":\"Cell cycle control protein 50A\",\"id\":\"Q9NV96\"},{\"label\":\"Centrosomal protein of 290 kDa\",\"id\":\"O15078\"},{\"label\":\"Chitinase-3-like protein 1\",\"id\":\"P36222\"},{\"label\":\"Chitotriosidase-1\",\"id\":\"Q13231\"},{\"label\":\"Choline transporter-like protein 2\",\"id\":\"Q8IWA5\"},{\"label\":\"Coactosin-like protein\",\"id\":\"Q14019\"},{\"label\":\"Coatomer subunit beta\",\"id\":\"P53618\"},{\"label\":\"Complement C3\",\"id\":\"P01024\"},{\"label\":\"Complement component C1q receptor\",\"id\":\"Q9NPY3\"},{\"label\":\"Complement decay-accelerating factor\",\"id\":\"P08174\"},{\"label\":\"Complement factor D\",\"id\":\"P00746\"},{\"label\":\"Complement receptor type 1\",\"id\":\"P17927\"},{\"label\":\"Copine-1\",\"id\":\"Q99829\"},{\"label\":\"Copine-3\",\"id\":\"O75131\"},{\"label\":\"Cullin-associated NEDD8-dissociated protein 1\",\"id\":\"Q86VP6\"},{\"label\":\"Cyclin-dependent kinase 13\",\"id\":\"Q14004\"},{\"label\":\"Cystatin-B\",\"id\":\"P04080\"},{\"label\":\"Cystatin-C\",\"id\":\"P01034\"},{\"label\":\"Cysteine-rich and transmembrane domain-containing protein 1\",\"id\":\"Q9H1C7\"},{\"label\":\"Cysteine-rich secretory protein 3\",\"id\":\"P54108\"},{\"label\":\"Cysteine-rich secretory protein LCCL domain-containing 2\",\"id\":\"Q9H0B8\"},{\"label\":\"Cytidine deaminase\",\"id\":\"P32320\"},{\"label\":\"Cytochrome b-245 heavy chain\",\"id\":\"P04839\"},{\"label\":\"Cytochrome b-245 light chain\",\"id\":\"P13498\"},{\"label\":\"Cytoplasmic FMR1-interacting protein 1\",\"id\":\"Q7L576\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoskeleton-associated protein 4\",\"id\":\"Q07065\"},{\"label\":\"Dedicator of cytokinesis protein 2\",\"id\":\"Q92608\"},{\"label\":\"Defensin alpha 4\",\"id\":\"P12838\"},{\"label\":\"Delta-aminolevulinic acid dehydratase\",\"id\":\"P13716\"},{\"label\":\"Deoxyribonuclease-1-like 1\",\"id\":\"P49184\"},{\"label\":\"Deoxyribose-phosphate aldolase\",\"id\":\"Q9Y315\"},{\"label\":\"Desmocollin-1\",\"id\":\"Q08554\"},{\"label\":\"Desmoglein-1\",\"id\":\"Q02413\"},{\"label\":\"Desmoplakin\",\"id\":\"P15924\"},{\"label\":\"Diacylglycerol O-acyltransferase 1\",\"id\":\"O75907\"},{\"label\":\"Diamine oxidase [copper-containing]\",\"id\":\"P19801\"},{\"label\":\"Dipeptidyl peptidase 1\",\"id\":\"P53634\"},{\"label\":\"Dipeptidyl peptidase 2\",\"id\":\"Q9UHL4\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 10\",\"id\":\"O14672\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 8\",\"id\":\"P78325\"},{\"label\":\"DnaJ homolog subfamily C member 13\",\"id\":\"O75165\"},{\"label\":\"DnaJ homolog subfamily C member 3\",\"id\":\"Q13217\"},{\"label\":\"DnaJ homolog subfamily C member 5\",\"id\":\"Q9H3Z4\"},{\"label\":\"Docking protein 3\",\"id\":\"Q7L591\"},{\"label\":\"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit\",\"id\":\"P39656\"},{\"label\":\"Drebrin-like protein\",\"id\":\"Q9UJU6\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain Tctex-type 1\",\"id\":\"P63172\"},{\"label\":\"E3 ubiquitin-protein ligase HUWE1\",\"id\":\"Q7Z6Z7\"},{\"label\":\"E3 ubiquitin-protein ligase KCMF1\",\"id\":\"Q9P0J7\"},{\"label\":\"E3 ubiquitin-protein ligase UBR4\",\"id\":\"Q5T4S7\"},{\"label\":\"EF-hand calcium-binding domain-containing protein 4B\",\"id\":\"Q9BSW2\"},{\"label\":\"Elongation factor 1-alpha 1\",\"id\":\"P68104\"},{\"label\":\"Elongation factor 2\",\"id\":\"P13639\"},{\"label\":\"Endoplasmic reticulum resident protein 44\",\"id\":\"Q9BS26\"},{\"label\":\"Eosinophil cationic protein\",\"id\":\"P12724\"},{\"label\":\"Eosinophil peroxidase\",\"id\":\"P11678\"},{\"label\":\"FAS-associated factor 2\",\"id\":\"Q96CS3\"},{\"label\":\"FERM and PDZ domain-containing protein 3\",\"id\":\"Q5JV73\"},{\"label\":\"Fatty acid-binding protein 5\",\"id\":\"Q01469\"},{\"label\":\"Ferritin heavy chain\",\"id\":\"P02794\"},{\"label\":\"Ferritin light chain\",\"id\":\"P02792\"},{\"label\":\"Fibroleukin\",\"id\":\"Q14314\"},{\"label\":\"Ficolin-1\",\"id\":\"O00602\"},{\"label\":\"Filaggrin-2\",\"id\":\"Q5D862\"},{\"label\":\"Folate receptor gamma\",\"id\":\"P41439\"},{\"label\":\"Fructose-bisphosphate aldolase A\",\"id\":\"P04075\"},{\"label\":\"Fructose-bisphosphate aldolase C\",\"id\":\"P09972\"},{\"label\":\"G-protein coupled receptor 84\",\"id\":\"Q9NQS5\"},{\"label\":\"GH3 domain-containing protein\",\"id\":\"Q8N2G8\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Galectin-3\",\"id\":\"P17931\"},{\"label\":\"Gamma-glutamyl hydrolase\",\"id\":\"Q92820\"},{\"label\":\"Ganglioside GM2 activator\",\"id\":\"P17900\"},{\"label\":\"Gasdermin-D\",\"id\":\"P57764\"},{\"label\":\"Gelsolin\",\"id\":\"P06396\"},{\"label\":\"Glia maturation factor gamma\",\"id\":\"O60234\"},{\"label\":\"Glioma pathogenesis-related protein 1\",\"id\":\"P48060\"},{\"label\":\"Glucose-6-phosphate isomerase\",\"id\":\"P06744\"},{\"label\":\"Glutaminyl-peptide cyclotransferase\",\"id\":\"Q16769\"},{\"label\":\"Glutathione S-transferase P\",\"id\":\"P09211\"},{\"label\":\"Glycogen debranching enzyme\",\"id\":\"P35573\"},{\"label\":\"Glycogen phosphorylase, brain form\",\"id\":\"P11216\"},{\"label\":\"Glycogen phosphorylase, liver form\",\"id\":\"P06737\"},{\"label\":\"Glycogenin-1\",\"id\":\"P46976\"},{\"label\":\"Golgin subfamily A member 7\",\"id\":\"Q7Z5G4\"},{\"label\":\"Grancalcin\",\"id\":\"P28676\"},{\"label\":\"Growth-regulated alpha protein\",\"id\":\"P09341\"},{\"label\":\"HLA class I histocompatibility antigen, B alpha chain\",\"id\":\"P01889\"},{\"label\":\"HLA class I histocompatibility antigen, C alpha chain\",\"id\":\"P10321\"},{\"label\":\"Haptoglobin\",\"id\":\"P00738\"},{\"label\":\"Heat shock 70 kDa protein 1A\",\"id\":\"P0DMV8\"},{\"label\":\"Heat shock 70 kDa protein 1B\",\"id\":\"P0DMV9\"},{\"label\":\"Heat shock 70 kDa protein 6\",\"id\":\"P17066\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Heme oxygenase 2\",\"id\":\"P30519\"},{\"label\":\"Heme-binding protein 2\",\"id\":\"Q9Y5Z4\"},{\"label\":\"Hemoglobin subunit beta\",\"id\":\"P68871\"},{\"label\":\"Heparan-alpha-glucosaminide N-acetyltransferase\",\"id\":\"Q68CP4\"},{\"label\":\"Heparanase\",\"id\":\"Q9Y251\"},{\"label\":\"Hexokinase-3\",\"id\":\"P52790\"},{\"label\":\"High affinity immunoglobulin epsilon receptor subunit gamma\",\"id\":\"P30273\"},{\"label\":\"High mobility group protein B1\",\"id\":\"P09429\"},{\"label\":\"Hornerin\",\"id\":\"Q86YZ3\"},{\"label\":\"IST1 homolog\",\"id\":\"P53990\"},{\"label\":\"Immunoglobulin alpha Fc receptor\",\"id\":\"P24071\"},{\"label\":\"Importin subunit beta-1\",\"id\":\"Q14974\"},{\"label\":\"Inosine-5'-monophosphate dehydrogenase 1\",\"id\":\"P20839\"},{\"label\":\"Inosine-5'-monophosphate dehydrogenase 2\",\"id\":\"P12268\"},{\"label\":\"Inositol 1,4,5-triphosphate receptor associated 2\",\"id\":\"Q12912\"},{\"label\":\"Integrin alpha-L\",\"id\":\"P20701\"},{\"label\":\"Integrin alpha-M\",\"id\":\"P11215\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin alpha-X\",\"id\":\"P20702\"},{\"label\":\"Integrin beta-2\",\"id\":\"P05107\"},{\"label\":\"Interleukin enhancer-binding factor 2\",\"id\":\"Q12905\"},{\"label\":\"Isocitrate dehydrogenase [NADP] cytoplasmic\",\"id\":\"O75874\"},{\"label\":\"Junction plakoglobin\",\"id\":\"P14923\"},{\"label\":\"Keratin, type II cytoskeletal 1\",\"id\":\"P04264\"},{\"label\":\"Kinetochore-associated protein DSN1 homolog\",\"id\":\"Q9H410\"},{\"label\":\"L-selectin\",\"id\":\"P14151\"},{\"label\":\"Lactotransferrin\",\"id\":\"P02788\"},{\"label\":\"Leucine-rich alpha-2-glycoprotein\",\"id\":\"P02750\"},{\"label\":\"Leucine-rich repeat-containing protein 7\",\"id\":\"Q96NW7\"},{\"label\":\"Leukocyte elastase inhibitor\",\"id\":\"P30740\"},{\"label\":\"Leukocyte immunoglobulin-like receptor subfamily A member 3\",\"id\":\"Q8N6C8\"},{\"label\":\"Leukocyte immunoglobulin-like receptor subfamily B member 2\",\"id\":\"Q8N423\"},{\"label\":\"Leukocyte immunoglobulin-like receptor subfamily B member 3\",\"id\":\"O75022\"},{\"label\":\"Leukocyte surface antigen CD47\",\"id\":\"Q08722\"},{\"label\":\"Leukocyte surface antigen CD53\",\"id\":\"P19397\"},{\"label\":\"Leukocyte-associated immunoglobulin-like receptor 1\",\"id\":\"Q6GTX8\"},{\"label\":\"Leukotriene A-4 hydrolase\",\"id\":\"P09960\"},{\"label\":\"Long-chain fatty acid transport protein 2\",\"id\":\"O14975\"},{\"label\":\"Low affinity immunoglobulin gamma Fc region receptor II-a\",\"id\":\"P12318\"},{\"label\":\"Low affinity immunoglobulin gamma Fc region receptor III-B\",\"id\":\"O75015\"},{\"label\":\"Lymphocyte function-associated antigen 3\",\"id\":\"P19256\"},{\"label\":\"Lysophosphatidylcholine acyltransferase 1\",\"id\":\"Q8NF37\"},{\"label\":\"Lysosomal Pro-X carboxypeptidase\",\"id\":\"P42785\"},{\"label\":\"Lysosomal alpha-glucosidase\",\"id\":\"P10253\"},{\"label\":\"Lysosomal alpha-mannosidase\",\"id\":\"O00754\"},{\"label\":\"Lysosomal protective protein\",\"id\":\"P10619\"},{\"label\":\"Lysosome-associated membrane glycoprotein 1\",\"id\":\"P11279\"},{\"label\":\"Lysosome-associated membrane glycoprotein 2\",\"id\":\"P13473\"},{\"label\":\"Lysozyme C\",\"id\":\"P61626\"},{\"label\":\"Macrophage migration inhibitory factor\",\"id\":\"P14174\"},{\"label\":\"Macrosialin\",\"id\":\"P34810\"},{\"label\":\"Magnesium transporter protein 1\",\"id\":\"Q9H0U3\"},{\"label\":\"Major vault protein\",\"id\":\"Q14764\"},{\"label\":\"Malectin\",\"id\":\"Q14165\"},{\"label\":\"Maltase-glucoamylase\",\"id\":\"O43451\"},{\"label\":\"Mast cell-expressed membrane protein 1\",\"id\":\"Q8IX19\"},{\"label\":\"Matrix metalloproteinase-25\",\"id\":\"Q9NPA2\"},{\"label\":\"Matrix metalloproteinase-9\",\"id\":\"P14780\"},{\"label\":\"Membrane protein BRI3\",\"id\":\"O95415\"},{\"label\":\"Membrane-associated progesterone receptor component 1\",\"id\":\"O00264\"},{\"label\":\"Membrane-spanning 4-domains subfamily A member 3\",\"id\":\"Q96HJ5\"},{\"label\":\"Metalloproteinase inhibitor 2\",\"id\":\"P16035\"},{\"label\":\"Microsomal glutathione S-transferase 1\",\"id\":\"P10620\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Motile sperm domain-containing protein 2\",\"id\":\"Q8NHP6\"},{\"label\":\"Multiple myeloma tumor-associated protein 2\",\"id\":\"Q9BU76\"},{\"label\":\"Myeloblastin\",\"id\":\"P24158\"},{\"label\":\"Myeloid cell nuclear differentiation antigen\",\"id\":\"P41218\"},{\"label\":\"Myeloid cell surface antigen CD33\",\"id\":\"P20138\"},{\"label\":\"Myeloperoxidase\",\"id\":\"P05164\"},{\"label\":\"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase\",\"id\":\"P20933\"},{\"label\":\"N-acetylgalactosamine-6-sulfatase\",\"id\":\"P34059\"},{\"label\":\"N-acetylglucosamine-6-sulfatase\",\"id\":\"P15586\"},{\"label\":\"N-formyl peptide receptor 2\",\"id\":\"P25090\"},{\"label\":\"NADH dehydrogenase [ubiquinone] 1 subunit C2\",\"id\":\"O95298\"},{\"label\":\"NADH-cytochrome b5 reductase 3\",\"id\":\"P00387\"},{\"label\":\"NFAT activation molecule 1\",\"id\":\"Q8NET5\"},{\"label\":\"NHL repeat-containing protein 3\",\"id\":\"Q5JS37\"},{\"label\":\"NPC intracellular cholesterol transporter 2\",\"id\":\"P61916\"},{\"label\":\"Natural resistance-associated macrophage protein 1\",\"id\":\"P49279\"},{\"label\":\"Nck-associated protein 1-like\",\"id\":\"P55160\"},{\"label\":\"Neprilysin\",\"id\":\"P08473\"},{\"label\":\"Neurobeachin-like protein 2\",\"id\":\"Q6ZNJ1\"},{\"label\":\"Neurofascin\",\"id\":\"O94856\"},{\"label\":\"Neuronal acetylcholine receptor subunit beta-4\",\"id\":\"P30926\"},{\"label\":\"Neutrophil collagenase\",\"id\":\"P22894\"},{\"label\":\"Neutrophil defensin 1\",\"id\":\"P59665\"},{\"label\":\"Neutrophil elastase\",\"id\":\"P08246\"},{\"label\":\"Neutrophil gelatinase-associated lipocalin\",\"id\":\"P80188\"},{\"label\":\"Nicastrin\",\"id\":\"Q92542\"},{\"label\":\"Nicotinate phosphoribosyltransferase\",\"id\":\"Q6XQN6\"},{\"label\":\"Non-secretory ribonuclease\",\"id\":\"P10153\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Nucleoside diphosphate kinase B\",\"id\":\"P22392\"},{\"label\":\"ORM1-like protein 3\",\"id\":\"Q8N138\"},{\"label\":\"Olfactomedin-4\",\"id\":\"Q6UX06\"},{\"label\":\"Omega-amidase NIT2\",\"id\":\"Q9NQR4\"},{\"label\":\"Osteoclast-associated immunoglobulin-like receptor\",\"id\":\"Q8IYS5\"},{\"label\":\"Osteoclast-stimulating factor 1\",\"id\":\"Q92882\"},{\"label\":\"Oxidized low-density lipoprotein receptor 1\",\"id\":\"P78380\"},{\"label\":\"P2X purinoceptor 1\",\"id\":\"P51575\"},{\"label\":\"Pantetheinase\",\"id\":\"O95497\"},{\"label\":\"Pentraxin-related protein PTX3\",\"id\":\"P26022\"},{\"label\":\"Peptidoglycan recognition protein 1\",\"id\":\"O75594\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase E\",\"id\":\"Q9UNP9\"},{\"label\":\"Peroxiredoxin-4\",\"id\":\"Q13162\"},{\"label\":\"Peroxiredoxin-6\",\"id\":\"P30041\"},{\"label\":\"Phosphoglucomutase-1\",\"id\":\"P36871\"},{\"label\":\"Phosphoglycerate mutase 1\",\"id\":\"P18669\"},{\"label\":\"Phospholipase D1\",\"id\":\"Q13393\"},{\"label\":\"Phospholipid-transporting ATPase IA\",\"id\":\"Q9Y2Q0\"},{\"label\":\"Phospholipid-transporting ATPase IF\",\"id\":\"Q9Y2G3\"},{\"label\":\"Phospholipid-transporting ATPase IH\",\"id\":\"P98196\"},{\"label\":\"Phosphopentomutase\",\"id\":\"Q96G03\"},{\"label\":\"Placenta-specific gene 8 protein\",\"id\":\"Q9NZF1\"},{\"label\":\"Plakophilin-1\",\"id\":\"Q13835\"},{\"label\":\"Plasma alpha-L-fucosidase\",\"id\":\"Q9BTY2\"},{\"label\":\"Platelet basic protein\",\"id\":\"P02775\"},{\"label\":\"Platelet endothelial cell adhesion molecule\",\"id\":\"P16284\"},{\"label\":\"Platelet glycoprotein 4\",\"id\":\"P16671\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit alpha2\",\"id\":\"P68402\"},{\"label\":\"Platelet-activating factor receptor\",\"id\":\"P25105\"},{\"label\":\"Pleckstrin homology domain-containing family O member 2\",\"id\":\"Q8TD55\"},{\"label\":\"Polymeric immunoglobulin receptor\",\"id\":\"P01833\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"},{\"label\":\"Presenilin-1\",\"id\":\"P49768\"},{\"label\":\"Pro-cathepsin H\",\"id\":\"P09668\"},{\"label\":\"Probable phospholipid-transporting ATPase IM\",\"id\":\"Q8TF62\"},{\"label\":\"Progranulin\",\"id\":\"P28799\"},{\"label\":\"Proliferation-associated protein 2G4\",\"id\":\"Q9UQ80\"},{\"label\":\"Properdin\",\"id\":\"P27918\"},{\"label\":\"Prosaposin\",\"id\":\"P07602\"},{\"label\":\"Prostaglandin E synthase 2\",\"id\":\"Q9H7Z7\"},{\"label\":\"Prostatic acid phosphatase\",\"id\":\"P15309\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Protein CREG1\",\"id\":\"O75629\"},{\"label\":\"Protein S100-A11\",\"id\":\"P31949\"},{\"label\":\"Protein S100-A12\",\"id\":\"P80511\"},{\"label\":\"Protein S100-A7\",\"id\":\"P31151\"},{\"label\":\"Protein S100-A8\",\"id\":\"P05109\"},{\"label\":\"Protein S100-A9\",\"id\":\"P06702\"},{\"label\":\"Protein S100-P\",\"id\":\"P25815\"},{\"label\":\"Protein diaphanous homolog 1\",\"id\":\"O60610\"},{\"label\":\"Protein kinase C delta type\",\"id\":\"Q05655\"},{\"label\":\"Protein lifeguard 3\",\"id\":\"Q969X1\"},{\"label\":\"Protein unc-13 homolog D\",\"id\":\"Q70J99\"},{\"label\":\"Protein yippee-like 5\",\"id\":\"P62699\"},{\"label\":\"Protein-arginine deiminase type-2\",\"id\":\"Q9Y2J8\"},{\"label\":\"Proteoglycan 3\",\"id\":\"Q9Y2Y8\"},{\"label\":\"Purine nucleoside phosphorylase\",\"id\":\"P00491\"},{\"label\":\"Putative HLA class I histocompatibility antigen, alpha chain H\",\"id\":\"P01893\"},{\"label\":\"Pyridoxal kinase\",\"id\":\"O00764\"},{\"label\":\"Pyruvate kinase PKM\",\"id\":\"P14618\"},{\"label\":\"Rab GDP dissociation inhibitor beta\",\"id\":\"P50395\"},{\"label\":\"Ragulator complex protein LAMTOR1\",\"id\":\"Q6IAA8\"},{\"label\":\"Ragulator complex protein LAMTOR2\",\"id\":\"Q9Y2Q5\"},{\"label\":\"Ragulator complex protein LAMTOR3\",\"id\":\"Q9UHA4\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP1\",\"id\":\"P46940\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP2\",\"id\":\"Q13576\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Ras-related protein Rab-10\",\"id\":\"P61026\"},{\"label\":\"Ras-related protein Rab-14\",\"id\":\"P61106\"},{\"label\":\"Ras-related protein Rab-18\",\"id\":\"Q9NP72\"},{\"label\":\"Ras-related protein Rab-24\",\"id\":\"Q969Q5\"},{\"label\":\"Ras-related protein Rab-27A\",\"id\":\"P51159\"},{\"label\":\"Ras-related protein Rab-31\",\"id\":\"Q13636\"},{\"label\":\"Ras-related protein Rab-37\",\"id\":\"Q96AX2\"},{\"label\":\"Ras-related protein Rab-3A\",\"id\":\"P20336\"},{\"label\":\"Ras-related protein Rab-3D\",\"id\":\"O95716\"},{\"label\":\"Ras-related protein Rab-44\",\"id\":\"Q7Z6P3\"},{\"label\":\"Ras-related protein Rab-4B\",\"id\":\"P61018\"},{\"label\":\"Ras-related protein Rab-5B\",\"id\":\"P61020\"},{\"label\":\"Ras-related protein Rab-5C\",\"id\":\"P51148\"},{\"label\":\"Ras-related protein Rab-6A\",\"id\":\"P20340\"},{\"label\":\"Ras-related protein Rab-7a\",\"id\":\"P51149\"},{\"label\":\"Ras-related protein Rab-9B\",\"id\":\"Q9NP90\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"},{\"label\":\"Ras-related protein Rap-2b\",\"id\":\"P61225\"},{\"label\":\"Ras-related protein Rap-2c\",\"id\":\"Q9Y3L5\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase C\",\"id\":\"P08575\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase N2\",\"id\":\"Q92932\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase beta\",\"id\":\"P23467\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase eta\",\"id\":\"Q12913\"},{\"label\":\"Renin receptor\",\"id\":\"O75787\"},{\"label\":\"Resistin\",\"id\":\"Q9HD89\"},{\"label\":\"Rho GTPase-activating protein 45\",\"id\":\"Q92619\"},{\"label\":\"Rho GTPase-activating protein 9\",\"id\":\"Q9BRR9\"},{\"label\":\"Rho-associated protein kinase 1\",\"id\":\"Q13464\"},{\"label\":\"Rho-related GTP-binding protein RhoF\",\"id\":\"Q9HBH0\"},{\"label\":\"Rho-related GTP-binding protein RhoG\",\"id\":\"P84095\"},{\"label\":\"Ribonuclease T2\",\"id\":\"O00584\"},{\"label\":\"Secretory carrier-associated membrane protein 1\",\"id\":\"O15126\"},{\"label\":\"Serine/threonine-protein kinase 10\",\"id\":\"O94804\"},{\"label\":\"Serine/threonine-protein kinase 11-interacting protein\",\"id\":\"Q8N1F8\"},{\"label\":\"Serine/threonine-protein phosphatase CPPED1\",\"id\":\"Q9BRF8\"},{\"label\":\"Serpin B10\",\"id\":\"P48595\"},{\"label\":\"Serpin B12\",\"id\":\"Q96P63\"},{\"label\":\"Serpin B3\",\"id\":\"P29508\"},{\"label\":\"Serpin B6\",\"id\":\"P35237\"},{\"label\":\"Sialic acid-binding Ig-like lectin 14\",\"id\":\"Q08ET2\"},{\"label\":\"Sialic acid-binding Ig-like lectin 5\",\"id\":\"O15389\"},{\"label\":\"Sialic acid-binding Ig-like lectin 9\",\"id\":\"Q9Y336\"},{\"label\":\"Sialidase-1\",\"id\":\"Q99519\"},{\"label\":\"Signal recognition particle 14 kDa protein\",\"id\":\"P37108\"},{\"label\":\"Signal-regulatory protein beta-1\",\"id\":\"O00241\"},{\"label\":\"Small VCP/p97-interacting protein\",\"id\":\"Q8NHG7\"},{\"label\":\"Soluble calcium-activated nucleotidase 1\",\"id\":\"Q8WVQ1\"},{\"label\":\"Solute carrier family 15 member 4\",\"id\":\"Q8N697\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 3\",\"id\":\"P11169\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 5\",\"id\":\"P22732\"},{\"label\":\"Solute carrier organic anion transporter family member 4C1\",\"id\":\"Q6ZQN7\"},{\"label\":\"Spectrin alpha chain, non-erythrocytic 1\",\"id\":\"Q13813\"},{\"label\":\"Sphingolipid delta(4)-desaturase DES1\",\"id\":\"O15121\"},{\"label\":\"Starch-binding domain-containing protein 1\",\"id\":\"O95210\"},{\"label\":\"Stimulator of interferon genes protein\",\"id\":\"Q86WV6\"},{\"label\":\"Stomatin\",\"id\":\"P27105\"},{\"label\":\"Sulfhydryl oxidase 1\",\"id\":\"O00391\"},{\"label\":\"Surfeit locus protein 4\",\"id\":\"O15260\"},{\"label\":\"Synaptic vesicle membrane protein VAT-1 homolog\",\"id\":\"Q99536\"},{\"label\":\"Synaptogyrin-1\",\"id\":\"O43759\"},{\"label\":\"Synaptosomal-associated protein 23\",\"id\":\"O00161\"},{\"label\":\"Synaptosomal-associated protein 25\",\"id\":\"P60880\"},{\"label\":\"Synaptosomal-associated protein 29\",\"id\":\"O95721\"},{\"label\":\"Syntenin-1\",\"id\":\"O00560\"},{\"label\":\"T-cell-interacting, activating receptor on myeloid cells protein 1\",\"id\":\"B6A8C7\"},{\"label\":\"T-complex protein 1 subunit beta\",\"id\":\"P78371\"},{\"label\":\"T-complex protein 1 subunit theta\",\"id\":\"P50990\"},{\"label\":\"TIR domain-containing adapter 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IQGAP1\",\"id\":\"P46940\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"},{\"label\":\"Serine/threonine-protein kinase A-Raf\",\"id\":\"P10398\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"},{\"label\":\"Talin-1\",\"id\":\"Q9Y490\"},{\"label\":\"Tyrosine-protein kinase CSK\",\"id\":\"P41240\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Vinculin\",\"id\":\"P18206\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": 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"[\"APBB1IP\",\"ARAF\",\"ARAF1\",\"ARB2\",\"ARR1\",\"ARR2\",\"ARRB1\",\"ARRB2\",\"BRAF\",\"BRAF1\",\"BRAP\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAM2\",\"CAMK\",\"CAMK-II\",\"CAMK2\",\"CAMK2A\",\"CAMK2B\",\"CAMK2D\",\"CAMK2G\",\"CAMKA\",\"CAMKB\",\"CAMKD\",\"CAMKG\",\"CNK1\",\"CNK2\",\"CNKSR1\",\"CNKSR2\",\"CSK\",\"CTAK1\",\"EMK2\",\"ERK1\",\"ERK2\",\"F8VWF\",\"FGA\",\"FGB\",\"FGG\",\"FN\",\"FN1\",\"GP2B\",\"GP3A\",\"HRAS\",\"HRAS1\",\"IQGAP1\",\"ITGA2B\",\"ITGAB\",\"ITGB3\",\"JAK2\",\"KIAA0051\",\"KIAA0902\",\"KIAA0968\",\"KIAA1027\",\"KRAS\",\"KRAS2\",\"KREV1\",\"KSR\",\"KSR1\",\"KSR2\",\"MAP2K1\",\"MAP2K2\",\"MAP3K11\",\"MAPK1\",\"MAPK3\",\"MARK3\",\"MEK1\",\"MEK2\",\"MKK2\",\"MLK3\",\"NRAS\",\"PBP\",\"PEBP\",\"PEBP1\",\"PHB\",\"PHB1\",\"PKS\",\"PKS2\",\"PREL1\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"PRKMK1\",\"PRKMK2\",\"PTK1\",\"RAF\",\"RAF1\",\"RAFB1\",\"RAP1A\",\"RAP1B\",\"RARP1\",\"RASK2\",\"RIAM\",\"RNF52\",\"SPRK\",\"SRC\",\"SRC1\",\"TLN\",\"TLN1\",\"VCL\",\"VWF\",\"YWHAB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ciprofloxacin ADME", "protein_name": "[{\"label\":\"Albumin\",\"id\":\"P02768\"},{\"label\":\"Broad substrate specificity ATP-binding cassette transporter ABCG2\",\"id\":\"Q9UNQ0\"},{\"label\":\"Organic anion transporter 3\",\"id\":\"Q8TCC7\"},{\"label\":\"Solute carrier family 22 member 1\",\"id\":\"O15245\"},{\"label\":\"Solute carrier organic anion transporter family member 1A2\",\"id\":\"P46721\"}]", "uniprot_id": "[\"O15245\",\"P02768\",\"P46721\",\"Q8TCC7\",\"Q9UNQ0\"]", "gene_symbol": "[\"ABCG2\",\"ABCP\",\"ALB\",\"BCRP\",\"BCRP1\",\"MXR\",\"OAT3\",\"OATP\",\"OATP1\",\"OATP1A2\",\"OCT1\",\"SLC21A3\",\"SLC22A1\",\"SLC22A8\",\"SLCO1A2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Calmodulin induced events", "protein_name": "[{\"label\":\"Beta-adrenergic receptor kinase 1\",\"id\":\"P25098\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Protein kinase C delta type\",\"id\":\"Q05655\"},{\"label\":\"Protein kinase C gamma type\",\"id\":\"P05129\"}]", "uniprot_id": "[\"P05129\",\"P0DP23\",\"P17252\",\"P25098\",\"Q05655\"]", "gene_symbol": "[\"ADRBK1\",\"BARK\",\"BARK1\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"GRK2\",\"PKCA\",\"PKCD\",\"PKCG\",\"PRKACA\",\"PRKCA\",\"PRKCD\",\"PRKCG\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Influenza Infection", "protein_name": "[{\"label\":\"Hemagglutinin\",\"id\":\"P03452\"},{\"label\":\"Matrix protein 1\",\"id\":\"P03485\"},{\"label\":\"Matrix protein 2\",\"id\":\"P06821\"},{\"label\":\"Neuraminidase\",\"id\":\"P03468\"},{\"label\":\"Nuclear export protein\",\"id\":\"P03508\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"}]", "uniprot_id": "[\"P03428\",\"P03431\",\"P03433\",\"P03452\",\"P03466\",\"P03468\",\"P03485\",\"P03508\",\"P06821\"]", "gene_symbol": "[\"HA\",\"M\",\"NA\",\"NP\",\"NS\",\"PA\",\"PB1\",\"PB2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Initiation of Nuclear Envelope (NE) Reformation", "protein_name": "[{\"label\":\"Ankyrin repeat and LEM domain-containing protein 2\",\"id\":\"Q86XL3\"},{\"label\":\"Barrier-to-autointegration factor\",\"id\":\"O75531\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Delta(14)-sterol reductase LBR\",\"id\":\"Q14739\"},{\"label\":\"Emerin\",\"id\":\"P50402\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"G2/mitotic-specific cyclin-B2\",\"id\":\"O95067\"},{\"label\":\"Importin subunit beta-1\",\"id\":\"Q14974\"},{\"label\":\"Inner nuclear membrane protein Man1\",\"id\":\"Q9Y2U8\"},{\"label\":\"LEM domain-containing protein 2\",\"id\":\"Q8NC56\"},{\"label\":\"Lamin-B1\",\"id\":\"P20700\"},{\"label\":\"NAD-dependent protein deacetylase sirtuin-2\",\"id\":\"Q8IXJ6\"},{\"label\":\"Serine/threonine-protein kinase VRK1\",\"id\":\"Q99986\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform\",\"id\":\"P63151\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"}]", "uniprot_id": "[\"O75531\",\"O95067\",\"P06493\",\"P14635\",\"P20700\",\"P30153\",\"P50402\",\"P63151\",\"P67775\",\"Q14739\",\"Q14974\",\"Q86XL3\",\"Q8IXJ6\",\"Q8NC56\",\"Q99986\",\"Q9Y2U8\"]", "gene_symbol": "[\"ANKLE2\",\"BAF\",\"BANF1\",\"BCRG1\",\"CCNB\",\"CCNB1\",\"CCNB2\",\"CDC2\",\"CDC28A\",\"CDK1\",\"CDKN1\",\"EDMD\",\"EMD\",\"KIAA0692\",\"KPNB1\",\"LBR\",\"LEM4\",\"LEMD2\",\"LEMD3\",\"LMN2\",\"LMNB\",\"LMNB1\",\"MAN1\",\"NTF97\",\"P34CDC2\",\"PPP2CA\",\"PPP2R1A\",\"PPP2R2A\",\"SIR2L\",\"SIR2L2\",\"SIRT2\",\"STA\",\"VRK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)", "protein_name": "[{\"label\":\"Vasopressin V2 receptor\",\"id\":\"P30518\"},{\"label\":\"Vasopressin-neurophysin 2-copeptin\",\"id\":\"P01185\"}]", "uniprot_id": "[\"P01185\",\"P30518\"]", "gene_symbol": "[\"ADHR\",\"ARVP\",\"AVP\",\"AVPR2\",\"DIR\",\"DIR3\",\"V2R\",\"VP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MPS VI - Maroteaux-Lamy syndrome", "protein_name": "[{\"label\":\"Arylsulfatase B\",\"id\":\"P15848\"}]", "uniprot_id": "[\"P15848\"]", "gene_symbol": "[\"ARSB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PLC beta mediated events", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1\",\"id\":\"Q9NQ66\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2\",\"id\":\"Q00722\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3\",\"id\":\"Q01970\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4\",\"id\":\"Q15147\"},{\"label\":\"Guanine nucleotide-binding protein G(q) subunit alpha\",\"id\":\"P50148\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-11\",\"id\":\"P29992\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-14\",\"id\":\"O95837\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-15\",\"id\":\"P30679\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1\",\"id\":\"Q14643\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2\",\"id\":\"Q14571\"},{\"label\":\"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3\",\"id\":\"Q14573\"},{\"label\":\"S-adenosylhomocysteine hydrolase-like protein 1\",\"id\":\"O43865\"}]", "uniprot_id": "[\"O43865\",\"O95837\",\"P29992\",\"P30679\",\"P50148\",\"Q00722\",\"Q01970\",\"Q14571\",\"Q14573\",\"Q14643\",\"Q15147\",\"Q9NQ66\"]", "gene_symbol": "[\"AHCYL1\",\"DCAL\",\"GA11\",\"GAQ\",\"GNA11\",\"GNA14\",\"GNA15\",\"GNA16\",\"GNAQ\",\"INSP3R1\",\"IRBIT\",\"ITPR1\",\"ITPR2\",\"ITPR3\",\"KIAA0581\",\"PLCB1\",\"PLCB2\",\"PLCB3\",\"PLCB4\",\"XPVKONA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CTNNB1 T41 mutants aren't phosphorylated", "protein_name": "[{\"label\":\"APC membrane recruitment protein 1\",\"id\":\"Q5JTC6\"},{\"label\":\"Adenomatous polyposis coli protein\",\"id\":\"P25054\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Casein kinase I isoform alpha\",\"id\":\"P48729\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O15169\",\"P25054\",\"P30153\",\"P30154\",\"P35222\",\"P48729\",\"P49841\",\"P62714\",\"P67775\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\"]", "gene_symbol": "[\"AMER1\",\"APC\",\"AXIN\",\"AXIN1\",\"CSNK1A1\",\"CTNNB\",\"CTNNB1\",\"DP2.5\",\"FAM123B\",\"GSK3B\",\"KIAA0044\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"WTX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ALKBH3 mediated reversal of alkylation damage", "protein_name": "[{\"label\":\"Activating signal cointegrator 1 complex subunit 1\",\"id\":\"Q8N9N2\"},{\"label\":\"Activating signal cointegrator 1 complex subunit 2\",\"id\":\"Q9H1I8\"},{\"label\":\"Activating signal cointegrator 1 complex subunit 3\",\"id\":\"Q8N3C0\"},{\"label\":\"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3\",\"id\":\"Q96Q83\"}]", "uniprot_id": "[\"Q8N3C0\",\"Q8N9N2\",\"Q96Q83\",\"Q9H1I8\"]", "gene_symbol": "[\"ABH3\",\"ALKBH3\",\"ASC1P100\",\"ASCC1\",\"ASCC2\",\"ASCC3\",\"DEPC1\",\"HELIC1\",\"RQT2\",\"RQT3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Metal sequestration by antimicrobial proteins", "protein_name": "[{\"label\":\"Lactotransferrin\",\"id\":\"P02788\"},{\"label\":\"Neutrophil gelatinase-associated lipocalin\",\"id\":\"P80188\"},{\"label\":\"Protein S100-A7\",\"id\":\"P31151\"},{\"label\":\"Protein S100-A7A\",\"id\":\"Q86SG5\"},{\"label\":\"Protein S100-A8\",\"id\":\"P05109\"},{\"label\":\"Protein S100-A9\",\"id\":\"P06702\"}]", "uniprot_id": "[\"P02788\",\"P05109\",\"P06702\",\"P31151\",\"P80188\",\"Q86SG5\"]", "gene_symbol": "[\"CAGA\",\"CAGB\",\"CFAG\",\"GIG12\",\"HNL\",\"LCN2\",\"LF\",\"LTF\",\"MRP14\",\"MRP8\",\"NGAL\",\"PSOR1\",\"S100A15\",\"S100A7\",\"S100A7A\",\"S100A7C\",\"S100A7L1\",\"S100A8\",\"S100A9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CDC42 GTPase cycle", "protein_name": "[{\"label\":\"ADP-ribosylation factor GTPase-activating protein 2\",\"id\":\"Q8N6H7\"},{\"label\":\"ADP-ribosylation factor GTPase-activating protein 3\",\"id\":\"Q9NP61\"},{\"label\":\"ARF GTPase-activating protein GIT1\",\"id\":\"Q9Y2X7\"},{\"label\":\"ARF GTPase-activating protein GIT2\",\"id\":\"Q14161\"},{\"label\":\"Actin nucleation-promoting factor WAS\",\"id\":\"P42768\"},{\"label\":\"Actin nucleation-promoting factor WASL\",\"id\":\"O00401\"},{\"label\":\"Active breakpoint cluster region-related protein\",\"id\":\"Q12979\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1\",\"id\":\"Q96P48\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2\",\"id\":\"Q8WZ64\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3\",\"id\":\"Q8WWN8\"},{\"label\":\"BAR/IMD domain-containing adapter protein 2\",\"id\":\"Q9UQB8\"},{\"label\":\"BTB/POZ domain-containing protein KCTD3\",\"id\":\"Q9Y597\"},{\"label\":\"Breakpoint cluster region protein\",\"id\":\"P11274\"},{\"label\":\"CDC42 small effector protein 2\",\"id\":\"Q9NRR3\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Cdc42 effector protein 1\",\"id\":\"Q00587\"},{\"label\":\"Cdc42 effector protein 2\",\"id\":\"O14613\"},{\"label\":\"Cdc42 effector protein 3\",\"id\":\"Q9UKI2\"},{\"label\":\"Cdc42 effector protein 4\",\"id\":\"Q9H3Q1\"},{\"label\":\"Cdc42 effector protein 5\",\"id\":\"Q6NZY7\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Copine-8\",\"id\":\"Q86YQ8\"},{\"label\":\"DEP domain-containing protein 1B\",\"id\":\"Q8WUY9\"},{\"label\":\"Dedicator of cytokinesis protein 10\",\"id\":\"Q96BY6\"},{\"label\":\"Dedicator of cytokinesis protein 11\",\"id\":\"Q5JSL3\"},{\"label\":\"Dedicator of cytokinesis protein 6\",\"id\":\"Q96HP0\"},{\"label\":\"Dedicator of cytokinesis protein 7\",\"id\":\"Q96N67\"},{\"label\":\"Dedicator of cytokinesis protein 8\",\"id\":\"Q8NF50\"},{\"label\":\"Dedicator of cytokinesis protein 9\",\"id\":\"Q9BZ29\"},{\"label\":\"Delta(14)-sterol reductase LBR\",\"id\":\"Q14739\"},{\"label\":\"Differentially expressed in FDCP 6 homolog\",\"id\":\"Q9H4E7\"},{\"label\":\"Disheveled-associated activator of morphogenesis 1\",\"id\":\"Q9Y4D1\"},{\"label\":\"Dynamin-binding protein\",\"id\":\"Q6XZF7\"},{\"label\":\"Ephexin-1\",\"id\":\"Q8N5V2\"},{\"label\":\"FERM, ARHGEF and pleckstrin domain-containing protein 1\",\"id\":\"Q9Y4F1\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 1\",\"id\":\"P98174\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 2\",\"id\":\"Q7Z6J4\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 3\",\"id\":\"Q5JSP0\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 4\",\"id\":\"Q96M96\"},{\"label\":\"Formin-binding protein 1-like\",\"id\":\"Q5T0N5\"},{\"label\":\"Formin-binding protein 1\",\"id\":\"Q96RU3\"},{\"label\":\"Formin-like protein 1\",\"id\":\"O95466\"},{\"label\":\"Formin-like protein 2\",\"id\":\"Q96PY5\"},{\"label\":\"Formin-like protein 3\",\"id\":\"Q8IVF7\"},{\"label\":\"GEM-interacting protein\",\"id\":\"Q9P107\"},{\"label\":\"Golgin subfamily A member 8R\",\"id\":\"I6L899\"},{\"label\":\"Guanine nucleotide exchange factor DBS\",\"id\":\"O15068\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Guanine nucleotide exchange factor VAV3\",\"id\":\"Q9UKW4\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-13\",\"id\":\"Q14344\"},{\"label\":\"Inactive Rho GTPase-activating protein 11B\",\"id\":\"Q3KRB8\"},{\"label\":\"Intersectin-1\",\"id\":\"Q15811\"},{\"label\":\"Junction plakoglobin\",\"id\":\"P14923\"},{\"label\":\"Kinectin\",\"id\":\"Q86UP2\"},{\"label\":\"Lamina-associated polypeptide 2, isoforms beta/gamma\",\"id\":\"P42167\"},{\"label\":\"Metalloreductase STEAP3\",\"id\":\"Q658P3\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 11\",\"id\":\"Q16584\"},{\"label\":\"N-chimaerin\",\"id\":\"P15882\"},{\"label\":\"Oligophrenin-1\",\"id\":\"O60890\"},{\"label\":\"Partitioning defective 6 homolog alpha\",\"id\":\"Q9NPB6\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein\",\"id\":\"Q70Z35\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phospholipase D1\",\"id\":\"Q13393\"},{\"label\":\"Pleckstrin homology domain-containing family G member 1\",\"id\":\"Q9ULL1\"},{\"label\":\"Pleckstrin homology domain-containing family G member 2\",\"id\":\"Q9H7P9\"},{\"label\":\"Pleckstrin homology domain-containing family G member 3\",\"id\":\"A1L390\"},{\"label\":\"Pleckstrin homology domain-containing family G member 4B\",\"id\":\"Q96PX9\"},{\"label\":\"Protein ECT2\",\"id\":\"Q9H8V3\"},{\"label\":\"Protein FAM13B\",\"id\":\"Q9NYF5\"},{\"label\":\"Protein diaphanous homolog 3\",\"id\":\"Q9NSV4\"},{\"label\":\"Protein scribble homolog\",\"id\":\"Q14160\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Puratrophin-1\",\"id\":\"Q58EX7\"},{\"label\":\"Rac GTPase-activating protein 1\",\"id\":\"Q9H0H5\"},{\"label\":\"Ragulator complex protein LAMTOR1\",\"id\":\"Q6IAA8\"},{\"label\":\"RalA-binding protein 1\",\"id\":\"Q15311\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP1\",\"id\":\"P46940\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP2\",\"id\":\"Q13576\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP3\",\"id\":\"Q86VI3\"},{\"label\":\"Ras-related protein Rab-7a\",\"id\":\"P51149\"},{\"label\":\"Ras-specific guanine nucleotide-releasing factor 2\",\"id\":\"O14827\"},{\"label\":\"Rho GDP-dissociation inhibitor 1\",\"id\":\"P52565\"},{\"label\":\"Rho GDP-dissociation inhibitor 2\",\"id\":\"P52566\"},{\"label\":\"Rho GDP-dissociation inhibitor 3\",\"id\":\"Q99819\"},{\"label\":\"Rho GTPase-activating protein 10\",\"id\":\"A1A4S6\"},{\"label\":\"Rho GTPase-activating protein 17\",\"id\":\"Q68EM7\"},{\"label\":\"Rho GTPase-activating protein 1\",\"id\":\"Q07960\"},{\"label\":\"Rho GTPase-activating protein 20\",\"id\":\"Q9P2F6\"},{\"label\":\"Rho GTPase-activating protein 21\",\"id\":\"Q5T5U3\"},{\"label\":\"Rho GTPase-activating protein 22\",\"id\":\"Q7Z5H3\"},{\"label\":\"Rho GTPase-activating protein 24\",\"id\":\"Q8N264\"},{\"label\":\"Rho GTPase-activating protein 26\",\"id\":\"Q9UNA1\"},{\"label\":\"Rho GTPase-activating protein 27\",\"id\":\"Q6ZUM4\"},{\"label\":\"Rho GTPase-activating protein 29\",\"id\":\"Q52LW3\"},{\"label\":\"Rho GTPase-activating protein 30\",\"id\":\"Q7Z6I6\"},{\"label\":\"Rho GTPase-activating protein 31\",\"id\":\"Q2M1Z3\"},{\"label\":\"Rho GTPase-activating protein 32\",\"id\":\"A7KAX9\"},{\"label\":\"Rho GTPase-activating protein 33\",\"id\":\"O14559\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho GTPase-activating protein 39\",\"id\":\"Q9C0H5\"},{\"label\":\"Rho GTPase-activating protein 40\",\"id\":\"Q5TG30\"},{\"label\":\"Rho GTPase-activating protein 42\",\"id\":\"A6NI28\"},{\"label\":\"Rho GTPase-activating protein 44\",\"id\":\"Q17R89\"},{\"label\":\"Rho GTPase-activating protein 45\",\"id\":\"Q92619\"},{\"label\":\"Rho GTPase-activating protein 4\",\"id\":\"P98171\"},{\"label\":\"Rho GTPase-activating protein 5\",\"id\":\"Q13017\"},{\"label\":\"Rho GTPase-activating protein 7\",\"id\":\"Q96QB1\"},{\"label\":\"Rho GTPase-activating protein 9\",\"id\":\"Q9BRR9\"},{\"label\":\"Rho GTPase-activating protein SYDE1\",\"id\":\"Q6ZW31\"},{\"label\":\"Rho guanine nucleotide exchange factor 10\",\"id\":\"O15013\"},{\"label\":\"Rho guanine nucleotide exchange factor 11\",\"id\":\"O15085\"},{\"label\":\"Rho guanine nucleotide exchange factor 12\",\"id\":\"Q9NZN5\"},{\"label\":\"Rho guanine nucleotide exchange factor 15\",\"id\":\"O94989\"},{\"label\":\"Rho guanine nucleotide exchange factor 16\",\"id\":\"Q5VV41\"},{\"label\":\"Rho guanine nucleotide exchange factor 19\",\"id\":\"Q8IW93\"},{\"label\":\"Rho guanine nucleotide exchange factor 25\",\"id\":\"Q86VW2\"},{\"label\":\"Rho guanine nucleotide exchange factor 26\",\"id\":\"Q96DR7\"},{\"label\":\"Rho guanine nucleotide exchange factor 4\",\"id\":\"Q9NR80\"},{\"label\":\"Rho guanine nucleotide exchange factor 5\",\"id\":\"Q12774\"},{\"label\":\"Rho guanine nucleotide exchange factor 6\",\"id\":\"Q15052\"},{\"label\":\"Rho guanine nucleotide exchange factor 7\",\"id\":\"Q14155\"},{\"label\":\"Rho guanine nucleotide exchange factor 9\",\"id\":\"O43307\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM1\",\"id\":\"Q13009\"},{\"label\":\"SH3 and PX domain-containing protein 2A\",\"id\":\"Q5TCZ1\"},{\"label\":\"SH3KBP1-binding 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"gtc_id": "[\"\"]" }, { "pathway_label": "TCF dependent signaling in response to WNT", "protein_name": "[{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Axin-2\",\"id\":\"Q9Y2T1\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Dickkopf-related protein 1\",\"id\":\"O94907\"},{\"label\":\"Dickkopf-related protein 2\",\"id\":\"Q9UBU2\"},{\"label\":\"Dickkopf-related protein 4\",\"id\":\"Q9UBT3\"},{\"label\":\"E3 ubiquitin-protein ligase RNF146\",\"id\":\"Q9NTX7\"},{\"label\":\"Frizzled-1\",\"id\":\"Q9UP38\"},{\"label\":\"Frizzled-2\",\"id\":\"Q14332\"},{\"label\":\"Kremen protein 1\",\"id\":\"Q96MU8\"},{\"label\":\"Kremen protein 2\",\"id\":\"Q8NCW0\"},{\"label\":\"Low-density lipoprotein receptor-related protein 5\",\"id\":\"O75197\"},{\"label\":\"Low-density lipoprotein receptor-related protein 6\",\"id\":\"O75581\"},{\"label\":\"Poly [ADP-ribose] polymerase tankyrase-1\",\"id\":\"O95271\"},{\"label\":\"Poly [ADP-ribose] polymerase tankyrase-2\",\"id\":\"Q9H2K2\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein Wnt-3a\",\"id\":\"P56704\"},{\"label\":\"Protein Wnt-4\",\"id\":\"P56705\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Protein Wnt-8a\",\"id\":\"Q9H1J5\"},{\"label\":\"Protein Wnt-8b\",\"id\":\"Q93098\"},{\"label\":\"Protein Wnt-9a\",\"id\":\"O14904\"},{\"label\":\"Proto-oncogene Wnt-1\",\"id\":\"P04628\"},{\"label\":\"Proto-oncogene Wnt-3\",\"id\":\"P56703\"},{\"label\":\"Sclerostin\",\"id\":\"Q9BQB4\"},{\"label\":\"Secreted frizzled-related protein 1\",\"id\":\"Q8N474\"},{\"label\":\"Secreted frizzled-related protein 2\",\"id\":\"Q96HF1\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-1\",\"id\":\"O14640\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-2\",\"id\":\"O14641\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-3\",\"id\":\"Q92997\"},{\"label\":\"Tyrosine-protein kinase RYK\",\"id\":\"P34925\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 34\",\"id\":\"Q70CQ2\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Wnt inhibitory factor 1\",\"id\":\"Q9Y5W5\"}]", "uniprot_id": "[\"O14640\",\"O14641\",\"O14904\",\"O15169\",\"O75197\",\"O75581\",\"O94907\",\"O95271\",\"P04628\",\"P0CG47\",\"P0CG48\",\"P34925\",\"P35222\",\"P41221\",\"P56703\",\"P56704\",\"P56705\",\"P62979\",\"P62987\",\"Q14332\",\"Q70CQ2\",\"Q8N474\",\"Q8NCW0\",\"Q92997\",\"Q93098\",\"Q96HF1\",\"Q96MU8\",\"Q9BQB4\",\"Q9H1J5\",\"Q9H2K2\",\"Q9NTX7\",\"Q9UBT3\",\"Q9UBU2\",\"Q9UP38\",\"Q9Y2T1\",\"Q9Y5W5\"]", "gene_symbol": "[\"AXIN\",\"AXIN1\",\"AXIN2\",\"CTNNB\",\"CTNNB1\",\"DKK1\",\"DKK2\",\"DKK4\",\"DVL1\",\"DVL2\",\"DVL3\",\"FRP\",\"FRP1\",\"FRP2\",\"FZD1\",\"FZD2\",\"INT1\",\"INT4\",\"JTK5A\",\"KIAA0208\",\"KIAA0570\",\"KIAA0729\",\"KREMEN\",\"KREMEN1\",\"KREMEN2\",\"KRM1\",\"KRM2\",\"LR3\",\"LRP5\",\"LRP6\",\"LRP7\",\"PARP5A\",\"PARP5B\",\"PARPL\",\"RNF146\",\"RPS27A\",\"RYK\",\"SARP1\",\"SARP2\",\"SFRP1\",\"SFRP2\",\"SOST\",\"TANK2\",\"TIN1\",\"TINF1\",\"TNKL\",\"TNKS\",\"TNKS1\",\"TNKS2\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"USP34\",\"WIF1\",\"WNT1\",\"WNT14\",\"WNT3\",\"WNT3A\",\"WNT4\",\"WNT5A\",\"WNT8A\",\"WNT8B\",\"WNT8D\",\"WNT9A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Initial triggering of complement", "protein_name": "[{\"label\":\"Collectin-10\",\"id\":\"Q9Y6Z7\"},{\"label\":\"Collectin-11\",\"id\":\"Q9BWP8\"},{\"label\":\"Complement C1q subcomponent subunit A\",\"id\":\"P02745\"},{\"label\":\"Complement C1q subcomponent subunit B\",\"id\":\"P02746\"},{\"label\":\"Complement C1q subcomponent subunit C\",\"id\":\"P02747\"},{\"label\":\"Complement C1r subcomponent\",\"id\":\"P00736\"},{\"label\":\"Complement C1s subcomponent\",\"id\":\"P09871\"},{\"label\":\"Complement C2\",\"id\":\"P06681\"},{\"label\":\"Complement C4-A\",\"id\":\"P0C0L4\"},{\"label\":\"Complement C4-B\",\"id\":\"P0C0L5\"},{\"label\":\"Ficolin-1\",\"id\":\"O00602\"},{\"label\":\"Ficolin-2\",\"id\":\"Q15485\"},{\"label\":\"Ficolin-3\",\"id\":\"O75636\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant gamma 1\",\"id\":\"P01857\"},{\"label\":\"Immunoglobulin heavy constant gamma 2\",\"id\":\"P01859\"},{\"label\":\"Immunoglobulin heavy constant gamma 3\",\"id\":\"P01860\"},{\"label\":\"Immunoglobulin heavy constant gamma 4\",\"id\":\"P01861\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 3-20\",\"id\":\"P01619\"},{\"label\":\"Immunoglobulin kappa variable 3D-20\",\"id\":\"A0A0C4DH25\"},{\"label\":\"Immunoglobulin kappa variable 4-1\",\"id\":\"P06312\"},{\"label\":\"Immunoglobulin kappa variable 5-2\",\"id\":\"P06315\"},{\"label\":\"Immunoglobulin lambda constant 1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 3\",\"id\":\"P0DOY3\"},{\"label\":\"Immunoglobulin lambda constant 6\",\"id\":\"P0CF74\"},{\"label\":\"Immunoglobulin lambda constant 7\",\"id\":\"A0M8Q6\"},{\"label\":\"Immunoglobulin lambda variable 1-40\",\"id\":\"P01703\"},{\"label\":\"Immunoglobulin lambda variable 1-44\",\"id\":\"P01699\"},{\"label\":\"Immunoglobulin lambda variable 1-47\",\"id\":\"P01700\"},{\"label\":\"Immunoglobulin lambda variable 1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 2-8\",\"id\":\"P01709\"},{\"label\":\"Immunoglobulin lambda variable 3-19\",\"id\":\"P01714\"},{\"label\":\"Immunoglobulin lambda variable 3-1\",\"id\":\"P01715\"},{\"label\":\"Immunoglobulin lambda variable 3-21\",\"id\":\"P80748\"},{\"label\":\"Immunoglobulin lambda variable 3-25\",\"id\":\"P01717\"},{\"label\":\"Immunoglobulin lambda variable 3-27\",\"id\":\"P01718\"},{\"label\":\"Immunoglobulin lambda variable 6-57\",\"id\":\"P01721\"},{\"label\":\"Immunoglobulin lambda variable 7-43\",\"id\":\"P04211\"},{\"label\":\"Immunolglobulin kappa light chain variable region L22 (Fragment)\",\"id\":\"A2NXD2\"},{\"label\":\"Mannan-binding lectin serine protease 1\",\"id\":\"P48740\"},{\"label\":\"Mannose-binding protein C\",\"id\":\"P11226\"},{\"label\":\"UGa8H (Fragment)\",\"id\":\"A2KUC3\"},{\"label\":\"V1-11 protein (Fragment)\",\"id\":\"Q5NV67\"},{\"label\":\"V1-13 protein (Fragment)\",\"id\":\"Q5NV69\"},{\"label\":\"V1-16 protein (Fragment)\",\"id\":\"Q5NV81\"},{\"label\":\"V1-20 protein (Fragment)\",\"id\":\"Q5NV86\"},{\"label\":\"V1-3 protein (Fragment)\",\"id\":\"Q5NV84\"},{\"label\":\"V1-5 protein (Fragment)\",\"id\":\"Q5NV65\"},{\"label\":\"V1-7 protein (Fragment)\",\"id\":\"Q5NV89\"},{\"label\":\"V1-9 protein (Fragment)\",\"id\":\"Q5NV66\"},{\"label\":\"V2-11 protein (Fragment)\",\"id\":\"Q5NV64\"},{\"label\":\"V2-15 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"gtc_id": "[\"\"]" }, { "pathway_label": "GPVI-mediated activation cascade", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2\",\"id\":\"P16885\"},{\"label\":\"3-phosphoinositide-dependent protein kinase 1\",\"id\":\"O15530\"},{\"label\":\"C-type lectin domain family 1 member B\",\"id\":\"Q9P126\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Guanine nucleotide exchange factor VAV3\",\"id\":\"Q9UKW4\"},{\"label\":\"High affinity immunoglobulin epsilon receptor subunit gamma\",\"id\":\"P30273\"},{\"label\":\"Linker for activation of T-cells family member 1\",\"id\":\"O43561\"},{\"label\":\"Lymphocyte cytosolic protein 2\",\"id\":\"Q13094\"},{\"label\":\"Megakaryocyte and platelet inhibitory receptor G6b\",\"id\":\"O95866\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit 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1\",\"id\":\"P63000\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 2\",\"id\":\"P15153\"},{\"label\":\"Rho-related GTP-binding protein RhoB\",\"id\":\"P62745\"},{\"label\":\"Rho-related GTP-binding protein RhoG\",\"id\":\"P84095\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase SYK\",\"id\":\"P43405\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"}]", "uniprot_id": 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Cascade", "protein_name": "[{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"}]", "uniprot_id": "[\"O15455\",\"Q8IUC6\"]", "gene_symbol": "[\"PRVTIRB\",\"TICAM1\",\"TLR3\",\"TRIF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Manipulation of host energy metabolism", "protein_name": "[{\"label\":\"6 kDa early secretory antigenic target\",\"id\":\"P9WNK7\"},{\"label\":\"Alpha-enolase\",\"id\":\"P06733\"},{\"label\":\"Phosphoglycerate kinase 1\",\"id\":\"P00558\"}]", "uniprot_id": "[\"P00558\",\"P06733\",\"P9WNK7\"]", "gene_symbol": "[\"ENO1\",\"ENO1L1\",\"MBPB1\",\"MPB1\",\"PGK1\",\"PGKA\",\"esaT6\",\"esxA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ub-specific processing proteases", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 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subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Androgen receptor\",\"id\":\"P10275\"},{\"label\":\"Antiviral innate immune response receptor RIG-I\",\"id\":\"O95786\"},{\"label\":\"Ataxin-7\",\"id\":\"O15265\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Axin-2\",\"id\":\"Q9Y2T1\"},{\"label\":\"Baculoviral IAP repeat-containing protein 2\",\"id\":\"Q13490\"},{\"label\":\"Baculoviral IAP repeat-containing protein 3\",\"id\":\"Q13489\"},{\"label\":\"Beclin-1\",\"id\":\"Q14457\"},{\"label\":\"Beta-2 adrenergic receptor\",\"id\":\"P07550\"},{\"label\":\"Beta-arrestin-1\",\"id\":\"P49407\"},{\"label\":\"Beta-arrestin-2\",\"id\":\"P32121\"},{\"label\":\"CAAX prenyl protease 2\",\"id\":\"Q9Y256\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Centriolar coiled-coil protein of 110 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"gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol", "protein_name": "[{\"label\":\"3 beta-hydroxysteroid dehydrogenase type 7\",\"id\":\"Q9H2F3\"},{\"label\":\"7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase\",\"id\":\"Q9UNU6\"},{\"label\":\"Acyl-coenzyme A thioesterase 8\",\"id\":\"O14734\"},{\"label\":\"Aldo-keto reductase family 1 member C1\",\"id\":\"Q04828\"},{\"label\":\"Aldo-keto reductase family 1 member C2\",\"id\":\"P52895\"},{\"label\":\"Aldo-keto reductase family 1 member C3\",\"id\":\"P42330\"},{\"label\":\"Aldo-keto reductase family 1 member C4\",\"id\":\"P17516\"},{\"label\":\"Aldo-keto reductase family 1 member D1\",\"id\":\"P51857\"},{\"label\":\"Alpha-methylacyl-CoA racemase\",\"id\":\"Q9UHK6\"},{\"label\":\"Bile acid receptor\",\"id\":\"Q96RI1\"},{\"label\":\"Bile acid-CoA\",\"id\":\"amino acid N-acyltransferase:Q14032\"},{\"label\":\"Bile salt export pump\",\"id\":\"O95342\"},{\"label\":\"Cytochrome P450 7A1\",\"id\":\"P22680\"},{\"label\":\"Cytochrome P450 7B1\",\"id\":\"O75881\"},{\"label\":\"Long-chain fatty acid transport protein 2\",\"id\":\"O14975\"},{\"label\":\"Long-chain fatty acid transport protein 5\",\"id\":\"Q9Y2P5\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Peroxisomal acyl-coenzyme A oxidase 2\",\"id\":\"Q99424\"},{\"label\":\"Peroxisomal multifunctional enzyme type 2\",\"id\":\"P51659\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Sterol 26-hydroxylase, mitochondrial\",\"id\":\"Q02318\"}]", "uniprot_id": "[\"O14734\",\"O14975\",\"O75881\",\"O95342\",\"P17516\",\"P19793\",\"P22680\",\"P42330\",\"P51659\",\"P51857\",\"P52895\",\"Q02318\",\"Q04828\",\"Q14032\",\"Q15596\",\"Q15788\",\"Q96RI1\",\"Q99424\",\"Q9H2F3\",\"Q9UHK6\",\"Q9UNU6\",\"Q9Y2P5\"]", "gene_symbol": 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cyclin-E2\",\"id\":\"O96020\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Protein lin-37 homolog\",\"id\":\"Q96GY3\"},{\"label\":\"Protein lin-52 homolog\",\"id\":\"Q52LA3\"},{\"label\":\"Protein lin-54 homolog\",\"id\":\"Q6MZP7\"},{\"label\":\"Protein lin-9 homolog\",\"id\":\"Q5TKA1\"},{\"label\":\"Retinoblastoma-like protein 1\",\"id\":\"P28749\"},{\"label\":\"Retinoblastoma-like protein 2\",\"id\":\"Q08999\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F4\",\"id\":\"Q16254\"},{\"label\":\"Transcription factor E2F5\",\"id\":\"Q15329\"}]", "uniprot_id": "[\"O96020\",\"P20248\",\"P24864\",\"P24941\",\"P28749\",\"P78396\",\"Q08999\",\"Q09028\",\"Q13547\",\"Q13627\",\"Q14186\",\"Q14188\",\"Q15329\",\"Q16254\",\"Q52LA3\",\"Q5TKA1\",\"Q6MZP7\",\"Q96GY3\"]", "gene_symbol": 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IC\",\"id\":\"Q9NR34\"}]", "uniprot_id": "[\"O60476\",\"P33908\",\"Q9NR34\"]", "gene_symbol": "[\"MAN1A1\",\"MAN1A2\",\"MAN1A3\",\"MAN1B\",\"MAN1C\",\"MAN1C1\"]", "gtc_id": "[\"G70323CJ\"]" }, { "pathway_label": "Biosynthesis of DPAn-6 SPMs", "protein_name": "[{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX12\",\"id\":\"P18054\"},{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX15\",\"id\":\"P16050\"}]", "uniprot_id": "[\"P16050\",\"P18054\"]", "gene_symbol": "[\"12LO\",\"ALOX12\",\"ALOX15\",\"LOG12\",\"LOG15\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)", "protein_name": "[{\"label\":\"Solute carrier organic anion transporter family member 1B1\",\"id\":\"Q9Y6L6\"}]", "uniprot_id": "[\"Q9Y6L6\"]", "gene_symbol": "[\"LST1\",\"OATP1B1\",\"OATP2\",\"OATPC\",\"SLC21A6\",\"SLCO1B1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S", "protein_name": "[{\"label\":\"Eukaryotic initiation factor 4A-I\",\"id\":\"P60842\"},{\"label\":\"Eukaryotic initiation factor 4A-II\",\"id\":\"Q14240\"},{\"label\":\"Eukaryotic translation initiation factor 4 gamma 1\",\"id\":\"Q04637\"},{\"label\":\"Eukaryotic translation initiation factor 4B\",\"id\":\"P23588\"},{\"label\":\"Eukaryotic translation initiation factor 4E-binding protein 1\",\"id\":\"Q13541\"},{\"label\":\"Eukaryotic translation initiation factor 4E\",\"id\":\"P06730\"},{\"label\":\"Eukaryotic translation initiation factor 4H\",\"id\":\"Q15056\"}]", "uniprot_id": "[\"P06730\",\"P23588\",\"P60842\",\"Q04637\",\"Q13541\",\"Q14240\",\"Q15056\"]", "gene_symbol": "[\"DDX2A\",\"DDX2B\",\"EIF4A\",\"EIF4A1\",\"EIF4A2\",\"EIF4B\",\"EIF4E\",\"EIF4EBP1\",\"EIF4EL1\",\"EIF4F\",\"EIF4G\",\"EIF4G1\",\"EIF4GI\",\"EIF4H\",\"KIAA0038\",\"WBSCR1\",\"WSCR1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by SCF-KIT", "protein_name": 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isoform\",\"id\":\"P42336\"},{\"label\":\"Protein kinase C alpha type\",\"id\":\"P17252\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase U\",\"id\":\"Q92729\"},{\"label\":\"Serine/threonine-protein kinase Chk1\",\"id\":\"O14757\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein kinase Fer\",\"id\":\"P16591\"},{\"label\":\"Tyrosine-protein kinase Fes/Fps\",\"id\":\"P07332\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase Tec\",\"id\":\"P42680\"},{\"label\":\"Tyrosine-protein kinase Yes\",\"id\":\"P07947\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O00459\",\"O14757\",\"O60674\",\"O75791\",\"P01111\",\"P01112\",\"P06239\",\"P06241\",\"P07332\",\"P07947\",\"P07948\",\"P10721\",\"P14780\",\"P15498\",\"P16591\",\"P17252\",\"P23946\",\"P27986\",\"P40763\",\"P42224\",\"P42229\",\"P42336\",\"P42680\",\"P51692\",\"P63000\",\"Q06124\",\"Q07889\",\"Q13322\",\"Q13588\",\"Q14451\",\"Q92569\",\"Q92729\",\"Q9UQC2\"]", "gene_symbol": 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"[\"\"]" }, { "pathway_label": "PIWI-interacting RNA (piRNA) biogenesis", "protein_name": "[{\"label\":\"ATP-dependent RNA helicase TDRD9\",\"id\":\"Q8NDG6\"},{\"label\":\"Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1\",\"id\":\"Q8WWH4\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Inactive peptidyl-prolyl cis-trans isomerase FKBP6\",\"id\":\"O75344\"},{\"label\":\"Mitochondrial cardiolipin hydrolase\",\"id\":\"Q8N2A8\"},{\"label\":\"Myb-related protein A\",\"id\":\"P10243\"},{\"label\":\"Piwi-like protein 1\",\"id\":\"Q96J94\"},{\"label\":\"Piwi-like protein 2\",\"id\":\"Q8TC59\"},{\"label\":\"Piwi-like protein 4\",\"id\":\"Q7Z3Z4\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX4\",\"id\":\"Q9NQI0\"},{\"label\":\"Protein maelstrom homolog\",\"id\":\"Q96JY0\"},{\"label\":\"Putative ATP-dependent RNA helicase TDRD12\",\"id\":\"Q587J7\"},{\"label\":\"RNA helicase 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"gtc_id": "[\"\"]" }, { "pathway_label": "Sodium-coupled sulphate, di- and tri-carboxylate transporters", "protein_name": "[{\"label\":\"Na(+)/citrate cotransporter\",\"id\":\"Q86YT5\"},{\"label\":\"Na(+)/dicarboxylate cotransporter 3\",\"id\":\"Q8WWT9\"},{\"label\":\"Solute carrier family 13 member 1\",\"id\":\"Q9BZW2\"},{\"label\":\"Solute carrier family 13 member 2\",\"id\":\"Q13183\"},{\"label\":\"Solute carrier family 13 member 4\",\"id\":\"Q9UKG4\"}]", "uniprot_id": "[\"Q13183\",\"Q86YT5\",\"Q8WWT9\",\"Q9BZW2\",\"Q9UKG4\"]", "gene_symbol": "[\"NACT\",\"NADC1\",\"NADC3\",\"NAS1\",\"NASI1\",\"SDCT1\",\"SDCT2\",\"SLC13A1\",\"SLC13A2\",\"SLC13A3\",\"SLC13A4\",\"SLC13A5\",\"SUT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "protein_name": "[{\"label\":\"CCR4-NOT transcription complex subunit 6\",\"id\":\"Q9ULM6\"},{\"label\":\"CCR4-NOT transcription complex subunit 9\",\"id\":\"Q92600\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"E3 SUMO-protein ligase EGR2\",\"id\":\"P11161\"},{\"label\":\"E3 SUMO-protein ligase PIAS2\",\"id\":\"O75928\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A-Bbd type 1\",\"id\":\"P0C5Y9\"},{\"label\":\"Histone H2A.J\",\"id\":\"Q9BTM1\"},{\"label\":\"Histone H2A.V\",\"id\":\"Q71UI9\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H3.3\",\"id\":\"P84243\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Histone-binding protein 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5\",\"id\":\"Q15291\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Retinoic acid receptor alpha\",\"id\":\"P10276\"},{\"label\":\"Retinoic acid receptor beta\",\"id\":\"P10826\"},{\"label\":\"Retinoic acid receptor gamma\",\"id\":\"P13631\"},{\"label\":\"Set1/Ash2 histone methyltransferase complex subunit ASH2\",\"id\":\"Q9UBL3\"},{\"label\":\"Transcription factor Jun\",\"id\":\"P05412\"},{\"label\":\"Transcription factor MafB\",\"id\":\"Q9Y5Q3\"},{\"label\":\"Transcriptional repressor CTCF\",\"id\":\"P49711\"},{\"label\":\"Transcriptional repressor protein YY1\",\"id\":\"P25490\"},{\"label\":\"WD repeat-containing protein 5\",\"id\":\"P61964\"},{\"label\":\"Zinc finger protein 335\",\"id\":\"Q9H4Z2\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Sodium-coupled phosphate cotransporters", "protein_name": "[{\"label\":\"Sodium-dependent phosphate transporter 1\",\"id\":\"Q8WUM9\"},{\"label\":\"Sodium-dependent phosphate transporter 2\",\"id\":\"Q08357\"}]", "uniprot_id": "[\"Q08357\",\"Q8WUM9\"]", "gene_symbol": "[\"GLVR1\",\"GLVR2\",\"PIT1\",\"PIT2\",\"SLC20A1\",\"SLC20A2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "The NLRP3 inflammasome", "protein_name": "[{\"label\":\"Alpha-hemolysin\",\"id\":\"P09616\"},{\"label\":\"Amyloid-beta precursor protein\",\"id\":\"P05067\"},{\"label\":\"Apoptosis-associated speck-like protein containing a CARD\",\"id\":\"Q9ULZ3\"},{\"label\":\"Caspase-1\",\"id\":\"P29466\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Heme oxygenase 1\",\"id\":\"P09601\"},{\"label\":\"NACHT, LRR and PYD domains-containing protein 3\",\"id\":\"Q96P20\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"P2X purinoceptor 7\",\"id\":\"Q99572\"},{\"label\":\"Pannexin-1\",\"id\":\"Q96RD7\"},{\"label\":\"Proline-serine-threonine phosphatase-interacting protein 1\",\"id\":\"O43586\"},{\"label\":\"Protein SGT1 homolog\",\"id\":\"Q9Y2Z0\"},{\"label\":\"Pyrin\",\"id\":\"O15553\"},{\"label\":\"Thioredoxin-interacting protein\",\"id\":\"Q9H3M7\"},{\"label\":\"Thioredoxin\",\"id\":\"P10599\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": "[\"O15553\",\"O43586\",\"P05067\",\"P08238\",\"P09601\",\"P09616\",\"P10599\",\"P19838\",\"P29466\",\"Q00653\",\"Q04206\",\"Q96P20\",\"Q96RD7\",\"Q99572\",\"Q9H3M7\",\"Q9ULZ3\",\"Q9Y2Z0\"]", "gene_symbol": 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"[\"ATF6B\",\"CREBL1\",\"G13\",\"GRP78\",\"HSPA5\",\"KIAA0091\",\"MBTPS1\",\"MBTPS2\",\"S1P\",\"S2P\",\"SKI1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HIV Transcription Initiation", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIE subunit 1\",\"id\":\"P29083\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"TATA-binding protein-associated factor 2N\",\"id\":\"Q92804\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription initiation factor IIA subunit 1\",\"id\":\"P52655\"},{\"label\":\"Transcription initiation factor IIA subunit 2\",\"id\":\"P52657\"},{\"label\":\"Transcription initiation factor IIB\",\"id\":\"Q00403\"},{\"label\":\"Transcription initiation factor IIE subunit beta\",\"id\":\"P29084\"},{\"label\":\"Transcription initiation factor TFIID subunit 1-like\",\"id\":\"Q8IZX4\"},{\"label\":\"Transcription initiation factor TFIID subunit 10\",\"id\":\"Q12962\"},{\"label\":\"Transcription initiation factor TFIID subunit 11\",\"id\":\"Q15544\"},{\"label\":\"Transcription initiation factor 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"gtc_id": "[\"\"]" }, { "pathway_label": "ponatinib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Melanin biosynthesis", "protein_name": "[{\"label\":\"5,6-dihydroxyindole-2-carboxylic acid oxidase\",\"id\":\"P17643\"},{\"label\":\"L-dopachrome tautomerase\",\"id\":\"P40126\"},{\"label\":\"Membrane-associated transporter protein\",\"id\":\"Q9UMX9\"},{\"label\":\"P protein\",\"id\":\"Q04671\"},{\"label\":\"Tyrosinase\",\"id\":\"P14679\"}]", "uniprot_id": "[\"P14679\",\"P17643\",\"P40126\",\"Q04671\",\"Q9UMX9\"]", "gene_symbol": "[\"AIM1\",\"CAS2\",\"D15S12\",\"DCT\",\"MATP\",\"OCA2\",\"P\",\"SLC45A2\",\"TYR\",\"TYRP\",\"TYRP1\",\"TYRP2\",\"TYRRP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "SUMOylation of immune response proteins", "protein_name": "[{\"label\":\"E3 SUMO-protein ligase PIAS3\",\"id\":\"Q9Y6X2\"},{\"label\":\"E3 SUMO-protein ligase PIAS4\",\"id\":\"Q8N2W9\"},{\"label\":\"E3 ubiquitin-protein ligase Topors\",\"id\":\"Q9NS56\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit epsilon\",\"id\":\"Q14164\"},{\"label\":\"Interferon-induced, double-stranded RNA-activated protein kinase\",\"id\":\"P19525\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"NF-kappa-B inhibitor alpha\",\"id\":\"P25963\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"},{\"label\":\"Small ubiquitin-related modifier 3\",\"id\":\"P55854\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": "[\"P19525\",\"P25963\",\"P55854\",\"P63165\",\"P63279\",\"Q00653\",\"Q04206\",\"Q14164\",\"Q8N2W9\",\"Q9NS56\",\"Q9Y6K9\",\"Q9Y6X2\"]", "gene_symbol": 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alpha\",\"id\":\"Q8NI17\"},{\"label\":\"Interleukin-31\",\"id\":\"Q6EBC2\"},{\"label\":\"Interleukin-6 receptor subunit beta\",\"id\":\"P40189\"},{\"label\":\"Leukemia inhibitory factor receptor\",\"id\":\"P42702\"},{\"label\":\"Leukemia inhibitory factor\",\"id\":\"P15018\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Oncostatin-M-specific receptor subunit beta\",\"id\":\"Q99650\"},{\"label\":\"Oncostatin-M\",\"id\":\"P13725\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"}]", "uniprot_id": "[\"O60674\",\"O75462\",\"P13725\",\"P15018\",\"P20809\",\"P23458\",\"P26441\",\"P26992\",\"P29597\",\"P40189\",\"P42702\",\"Q14626\",\"Q16619\",\"Q6EBC2\",\"Q8NI17\",\"Q99650\",\"Q9UBD9\"]", "gene_symbol": "[\"BSF3\",\"CLC\",\"CLCF1\",\"CNTF\",\"CNTFR\",\"CRL3\",\"CRLF1\",\"CTF1\",\"GPL\",\"HILDA\",\"IL11\",\"IL11RA\",\"IL31\",\"IL31RA\",\"IL6ST\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"JAK2\",\"LIF\",\"LIFR\",\"NNT1\",\"OSM\",\"OSMR\",\"OSMRB\",\"TYK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC34A2 causes PALM", "protein_name": "[{\"label\":\"Sodium-dependent phosphate transport protein 2B\",\"id\":\"O95436\"}]", "uniprot_id": "[\"O95436\"]", "gene_symbol": "[\"SLC34A2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Adenylate cyclase inhibitory pathway", "protein_name": "[{\"label\":\"Adenylate cyclase type 1\",\"id\":\"Q08828\"},{\"label\":\"Adenylate cyclase type 2\",\"id\":\"Q08462\"},{\"label\":\"Adenylate cyclase type 3\",\"id\":\"O60266\"},{\"label\":\"Adenylate cyclase type 4\",\"id\":\"Q8NFM4\"},{\"label\":\"Adenylate cyclase type 5\",\"id\":\"O95622\"},{\"label\":\"Adenylate cyclase type 6\",\"id\":\"O43306\"},{\"label\":\"Adenylate cyclase type 7\",\"id\":\"P51828\"},{\"label\":\"Adenylate cyclase type 8\",\"id\":\"P40145\"},{\"label\":\"Adenylate cyclase type 9\",\"id\":\"O60503\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-1\",\"id\":\"P63096\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-2\",\"id\":\"P04899\"},{\"label\":\"Guanine nucleotide-binding protein G(i) subunit alpha-3\",\"id\":\"P08754\"},{\"label\":\"Guanine nucleotide-binding protein G(olf) subunit alpha\",\"id\":\"P38405\"},{\"label\":\"Guanine nucleotide-binding protein G(t) subunit alpha-3\",\"id\":\"A8MTJ3\"}]", "uniprot_id": "[\"A8MTJ3\",\"O43306\",\"O60266\",\"O60503\",\"O95622\",\"P04899\",\"P08754\",\"P38405\",\"P40145\",\"P51828\",\"P63096\",\"Q08462\",\"Q08828\",\"Q8NFM4\"]", "gene_symbol": 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A\",\"id\":\"A6NLW8\"},{\"label\":\"Double homeobox protein B\",\"id\":\"A0A1W2PPF3\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Lysine-specific demethylase 4E\",\"id\":\"B2RXH2\"},{\"label\":\"Paired-like homeodomain transcription factor LEUTX\",\"id\":\"A8MZ59\"},{\"label\":\"Terminal uridylyltransferase 4\",\"id\":\"Q5TAX3\"},{\"label\":\"Terminal uridylyltransferase 7\",\"id\":\"Q5VYS8\"},{\"label\":\"Tetra-peptide repeat homeobox protein 1\",\"id\":\"Q8N7U7\"},{\"label\":\"Tetra-peptide repeat homeobox-like protein\",\"id\":\"Q17RH7\"},{\"label\":\"Tetrapeptide repeat homeobox protein 2\",\"id\":\"P0DV77\"},{\"label\":\"Transcriptional coactivator YAP1\",\"id\":\"P46937\"},{\"label\":\"Transcriptional enhancer factor TEF-3\",\"id\":\"Q15561\"},{\"label\":\"Zinc finger and SCAN domain-containing protein 4\",\"id\":\"Q8NAM6\"}]", "uniprot_id": 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3\",\"id\":\"Q8IVF7\"},{\"label\":\"Guanine nucleotide exchange factor DBS\",\"id\":\"O15068\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Junction plakoglobin\",\"id\":\"P14923\"},{\"label\":\"Lamina-associated polypeptide 2, isoforms beta/gamma\",\"id\":\"P42167\"},{\"label\":\"Macoilin\",\"id\":\"Q8N5G2\"},{\"label\":\"Oligophrenin-1\",\"id\":\"O60890\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Protein ERGIC-53\",\"id\":\"P49257\"},{\"label\":\"Protein diaphanous homolog 1\",\"id\":\"O60610\"},{\"label\":\"Protein diaphanous homolog 3\",\"id\":\"Q9NSV4\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Rac GTPase-activating protein 1\",\"id\":\"Q9H0H5\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP1\",\"id\":\"P46940\"},{\"label\":\"Ras GTPase-activating-like protein IQGAP3\",\"id\":\"Q86VI3\"},{\"label\":\"Rho GDP-dissociation inhibitor 1\",\"id\":\"P52565\"},{\"label\":\"Rho GTPase-activating protein 18\",\"id\":\"Q8N392\"},{\"label\":\"Rho GTPase-activating protein 1\",\"id\":\"Q07960\"},{\"label\":\"Rho GTPase-activating protein 21\",\"id\":\"Q5T5U3\"},{\"label\":\"Rho GTPase-activating protein 26\",\"id\":\"Q9UNA1\"},{\"label\":\"Rho GTPase-activating protein 32\",\"id\":\"A7KAX9\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho GTPase-activating protein 39\",\"id\":\"Q9C0H5\"},{\"label\":\"Rho GTPase-activating protein 5\",\"id\":\"Q13017\"},{\"label\":\"Rho GTPase-activating protein 7\",\"id\":\"Q96QB1\"},{\"label\":\"Rho guanine nucleotide exchange factor 10-like protein\",\"id\":\"Q9HCE6\"},{\"label\":\"Rho guanine nucleotide exchange factor 10\",\"id\":\"O15013\"},{\"label\":\"Rho guanine nucleotide exchange factor 11\",\"id\":\"O15085\"},{\"label\":\"Rho guanine 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"gtc_id": "[\"\"]" }, { "pathway_label": "vRNP Assembly", "protein_name": "[{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Importin-5\",\"id\":\"O00410\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"}]", "uniprot_id": "[\"O00410\",\"P03428\",\"P03431\",\"P03433\",\"P03466\",\"P07900\"]", "gene_symbol": "[\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"IPO5\",\"KPNB3\",\"NP\",\"PA\",\"PB1\",\"PB2\",\"RANBP5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synaptic adhesion-like molecules", "protein_name": "[{\"label\":\"Disks large homolog 1\",\"id\":\"Q12959\"},{\"label\":\"Disks large homolog 3\",\"id\":\"Q92796\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Flotillin-1\",\"id\":\"O75955\"},{\"label\":\"Flotillin-2\",\"id\":\"Q14254\"},{\"label\":\"Glutamate receptor 1\",\"id\":\"P42261\"},{\"label\":\"Glutamate receptor 3\",\"id\":\"P42263\"},{\"label\":\"Glutamate receptor 4\",\"id\":\"P48058\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 1\",\"id\":\"Q05586\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2A\",\"id\":\"Q12879\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2C\",\"id\":\"Q14957\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2D\",\"id\":\"O15399\"},{\"label\":\"Leucine-rich repeat and fibronectin type III domain-containing protein 1\",\"id\":\"Q9P244\"},{\"label\":\"Leucine-rich repeat and fibronectin type-III domain-containing protein 2\",\"id\":\"Q9ULH4\"},{\"label\":\"Leucine-rich repeat and fibronectin type-III domain-containing protein 3\",\"id\":\"Q9BTN0\"},{\"label\":\"Leucine-rich repeat and fibronectin type-III domain-containing protein 4\",\"id\":\"Q6PJG9\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase F\",\"id\":\"P10586\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase S\",\"id\":\"Q13332\"},{\"label\":\"Receptor-type tyrosine-protein phosphatase delta\",\"id\":\"P23468\"},{\"label\":\"Reticulon-3\",\"id\":\"O95197\"}]", "uniprot_id": "[\"O15399\",\"O75955\",\"O95197\",\"P10586\",\"P23468\",\"P42261\",\"P42263\",\"P48058\",\"P78352\",\"Q05586\",\"Q12879\",\"Q12959\",\"Q13224\",\"Q13332\",\"Q14254\",\"Q14957\",\"Q6PJG9\",\"Q92796\",\"Q9BTN0\",\"Q9P244\",\"Q9ULH4\"]", "gene_symbol": 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4\",\"id\":\"P18085\"},{\"label\":\"ADP-ribosylation factor 5\",\"id\":\"P84085\"},{\"label\":\"ADP-ribosylation factor GTPase-activating protein 1\",\"id\":\"Q8N6T3\"},{\"label\":\"ADP-ribosylation factor GTPase-activating protein 2\",\"id\":\"Q8N6H7\"},{\"label\":\"ADP-ribosylation factor GTPase-activating protein 3\",\"id\":\"Q9NP61\"},{\"label\":\"Actin-related protein 10\",\"id\":\"Q9NZ32\"},{\"label\":\"Alpha-centractin\",\"id\":\"P61163\"},{\"label\":\"Alpha-soluble NSF attachment protein\",\"id\":\"P54920\"},{\"label\":\"Ankyrin-1\",\"id\":\"P16157\"},{\"label\":\"Ankyrin-2\",\"id\":\"Q01484\"},{\"label\":\"Ankyrin-3\",\"id\":\"Q12955\"},{\"label\":\"BET1 homolog\",\"id\":\"O15155\"},{\"label\":\"BET1-like protein\",\"id\":\"Q9NYM9\"},{\"label\":\"Beta-soluble NSF attachment protein\",\"id\":\"Q9H115\"},{\"label\":\"CD59 glycoprotein\",\"id\":\"P13987\"},{\"label\":\"Coatomer subunit alpha\",\"id\":\"P53621\"},{\"label\":\"Coatomer subunit 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oligomeric Golgi complex subunit 7\",\"id\":\"P83436\"},{\"label\":\"Conserved oligomeric Golgi complex subunit 8\",\"id\":\"Q96MW5\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 1\",\"id\":\"O14576\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 2\",\"id\":\"O43237\"},{\"label\":\"Dynactin subunit 1\",\"id\":\"Q14203\"},{\"label\":\"Dynactin subunit 2\",\"id\":\"Q13561\"},{\"label\":\"Dynactin subunit 3\",\"id\":\"O75935\"},{\"label\":\"Dynactin subunit 4\",\"id\":\"Q9UJW0\"},{\"label\":\"Dynactin subunit 5\",\"id\":\"Q9BTE1\"},{\"label\":\"Dynactin subunit 6\",\"id\":\"O00399\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"ER lumen 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10\",\"id\":\"P49755\"},{\"label\":\"Transmembrane emp24 domain-containing protein 2\",\"id\":\"Q15363\"},{\"label\":\"Transmembrane emp24 domain-containing protein 3\",\"id\":\"Q9Y3Q3\"},{\"label\":\"Transmembrane emp24 domain-containing protein 7\",\"id\":\"Q9Y3B3\"},{\"label\":\"Transmembrane emp24 domain-containing protein 9\",\"id\":\"Q9BVK6\"},{\"label\":\"Transmembrane protein 115\",\"id\":\"Q12893\"},{\"label\":\"Vesicle-fusing ATPase\",\"id\":\"P46459\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of PE", "protein_name": "[{\"label\":\"Choline kinase alpha\",\"id\":\"P35790\"},{\"label\":\"Choline/ethanolamine kinase\",\"id\":\"Q9Y259\"},{\"label\":\"Choline/ethanolaminephosphotransferase 1\",\"id\":\"Q9Y6K0\"},{\"label\":\"Ethanolamine kinase 1\",\"id\":\"Q9HBU6\"},{\"label\":\"Ethanolamine kinase 2\",\"id\":\"Q9NVF9\"},{\"label\":\"Ethanolamine-phosphate cytidylyltransferase\",\"id\":\"Q99447\"},{\"label\":\"Ethanolamine-phosphate phospho-lyase\",\"id\":\"Q8TBG4\"},{\"label\":\"Ethanolaminephosphotransferase 1\",\"id\":\"Q9C0D9\"},{\"label\":\"Phosphatidate phosphatase LPIN1\",\"id\":\"Q14693\"},{\"label\":\"Phosphatidate phosphatase LPIN2\",\"id\":\"Q92539\"},{\"label\":\"Phosphatidate phosphatase LPIN3\",\"id\":\"Q9BQK8\"},{\"label\":\"Phosphatidylserine decarboxylase proenzyme, mitochondrial\",\"id\":\"Q9UG56\"},{\"label\":\"Phosphoethanolamine/phosphocholine phosphatase\",\"id\":\"Q8TCT1\"}]", "uniprot_id": 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ligase RING2\",\"id\":\"Q99496\"},{\"label\":\"E3 ubiquitin-protein ligase Topors\",\"id\":\"Q9NS56\"},{\"label\":\"E3 ubiquitin-protein ligase UHRF2\",\"id\":\"Q96PU4\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Homeodomain-interacting protein kinase 2\",\"id\":\"Q9H2X6\"},{\"label\":\"Inhibitor of growth protein 2\",\"id\":\"Q9H160\"},{\"label\":\"Methyl-CpG-binding domain protein 1\",\"id\":\"Q9UIS9\"},{\"label\":\"Myocardin-related transcription factor A\",\"id\":\"Q969V6\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Nuclear receptor-interacting protein 1\",\"id\":\"P48552\"},{\"label\":\"Nucleophosmin\",\"id\":\"P06748\"},{\"label\":\"Paired amphipathic helix protein Sin3a\",\"id\":\"Q96ST3\"},{\"label\":\"Parkinson disease protein 7\",\"id\":\"Q99497\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha\",\"id\":\"Q9UBK2\"},{\"label\":\"Polycomb complex protein BMI-1\",\"id\":\"P35226\"},{\"label\":\"Polycomb group RING finger protein 2\",\"id\":\"P35227\"},{\"label\":\"Polyhomeotic-like protein 1\",\"id\":\"P78364\"},{\"label\":\"Polyhomeotic-like protein 2\",\"id\":\"Q8IXK0\"},{\"label\":\"Polyhomeotic-like protein 3\",\"id\":\"Q8NDX5\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX17\",\"id\":\"Q92841\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX5\",\"id\":\"P17844\"},{\"label\":\"SUMO-conjugating enzyme UBC9\",\"id\":\"P63279\"},{\"label\":\"Scaffold attachment factor B1\",\"id\":\"Q15424\"},{\"label\":\"Small ubiquitin-related modifier 1\",\"id\":\"P63165\"},{\"label\":\"Small ubiquitin-related modifier 2\",\"id\":\"P61956\"},{\"label\":\"Small ubiquitin-related modifier 3\",\"id\":\"P55854\"},{\"label\":\"Transcription intermediary factor 1-beta\",\"id\":\"Q13263\"},{\"label\":\"Zinc finger protein 131\",\"id\":\"P52739\"},{\"label\":\"Zinc finger protein 350\",\"id\":\"Q9GZX5\"}]", "uniprot_id": "[\"O00257\",\"O75925\",\"P06748\",\"P17844\",\"P35226\",\"P35227\",\"P48552\",\"P52739\",\"P55854\",\"P61956\",\"P63165\",\"P63279\",\"P78364\",\"Q06587\",\"Q09472\",\"Q13263\",\"Q13363\",\"Q14781\",\"Q15424\",\"Q15596\",\"Q15788\",\"Q8IXK0\",\"Q8N2W9\",\"Q8NDX5\",\"Q92793\",\"Q92841\",\"Q969V6\",\"Q96PU4\",\"Q96ST3\",\"Q99496\",\"Q99497\",\"Q9GZX5\",\"Q9H160\",\"Q9H2X6\",\"Q9HC52\",\"Q9NS56\",\"Q9UBK2\",\"Q9UER7\",\"Q9UIS9\",\"Q9UKL3\",\"Q9Y618\",\"Q9Y6X2\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Variant SLC6A14 may confer susceptibility towards obesity", "protein_name": "[{\"label\":\"Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)\",\"id\":\"Q9UN76\"}]", "uniprot_id": "[\"Q9UN76\"]", "gene_symbol": "[\"SLC6A14\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mitochondrial RNA degradation", "protein_name": "[{\"label\":\"ATP-dependent RNA helicase SUPV3L1, mitochondrial\",\"id\":\"Q8IYB8\"},{\"label\":\"G-rich sequence factor 1\",\"id\":\"Q12849\"},{\"label\":\"Leucine-rich PPR motif-containing protein, mitochondrial\",\"id\":\"P42704\"},{\"label\":\"Oligoribonuclease, mitochondrial\",\"id\":\"Q9Y3B8\"},{\"label\":\"Polyribonucleotide nucleotidyltransferase 1, mitochondrial\",\"id\":\"Q8TCS8\"},{\"label\":\"SRA stem-loop-interacting RNA-binding protein, mitochondrial\",\"id\":\"Q9GZT3\"}]", "uniprot_id": "[\"P42704\",\"Q12849\",\"Q8IYB8\",\"Q8TCS8\",\"Q9GZT3\",\"Q9Y3B8\"]", "gene_symbol": "[\"C14orf156\",\"GRSF1\",\"LRP130\",\"LRPPRC\",\"PNPASE\",\"PNPT1\",\"REXO2\",\"SFN\",\"SLIRP\",\"SMFN\",\"SUPV3L1\",\"SUV3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CaMK IV-mediated phosphorylation of CREB", "protein_name": "[{\"label\":\"Calcium/calmodulin-dependent protein kinase kinase 1\",\"id\":\"Q8N5S9\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase kinase 2\",\"id\":\"Q96RR4\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type IV\",\"id\":\"Q16566\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Importin subunit alpha-1\",\"id\":\"P52292\"}]", "uniprot_id": "[\"P0DP23\",\"P52292\",\"Q13554\",\"Q13555\",\"Q13557\",\"Q16566\",\"Q8N5S9\",\"Q96RR4\",\"Q9UQM7\"]", "gene_symbol": "[\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAM2\",\"CAMK\",\"CAMK-GR\",\"CAMK-II\",\"CAMK2\",\"CAMK2A\",\"CAMK2B\",\"CAMK2D\",\"CAMK2G\",\"CAMK4\",\"CAMKA\",\"CAMKB\",\"CAMKD\",\"CAMKG\",\"CAMKIV\",\"CAMKK1\",\"CAMKK2\",\"CAMKKA\",\"CAMKKB\",\"KIAA0787\",\"KIAA0968\",\"KPNA2\",\"RCH1\",\"SRP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Binding of TCF/LEF:CTNNB1 to target gene promoters", "protein_name": "[{\"label\":\"Axin-2\",\"id\":\"Q9Y2T1\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Runt-related transcription factor 3\",\"id\":\"Q13761\"},{\"label\":\"Transcription factor 7-like 1\",\"id\":\"Q9HCS4\"},{\"label\":\"Transcription factor 7-like 2\",\"id\":\"Q9NQB0\"},{\"label\":\"Transcription factor 7\",\"id\":\"P36402\"}]", "uniprot_id": "[\"P01106\",\"P35222\",\"P36402\",\"Q13761\",\"Q9HCS4\",\"Q9NQB0\",\"Q9UJU2\",\"Q9Y2T1\"]", "gene_symbol": "[\"AML2\",\"AXIN2\",\"BHLHE39\",\"CBFA3\",\"CTNNB\",\"CTNNB1\",\"LEF1\",\"MYC\",\"PEBP2A3\",\"RUNX3\",\"TCF1\",\"TCF3\",\"TCF4\",\"TCF7\",\"TCF7L1\",\"TCF7L2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Polymerase II Pre-transcription Events", "protein_name": "[{\"label\":\"AF4/FMR2 family member 4\",\"id\":\"Q9UHB7\"},{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-K\",\"id\":\"O75909\"},{\"label\":\"Cyclin-T1\",\"id\":\"O60563\"},{\"label\":\"Cyclin-T2\",\"id\":\"O60583\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"Cyclin-dependent kinase 9\",\"id\":\"P50750\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"ELL-associated factor 1\",\"id\":\"Q96JC9\"},{\"label\":\"ELL-associated factor 2\",\"id\":\"Q96CJ1\"},{\"label\":\"Elongin-A2\",\"id\":\"Q8IYF1\"},{\"label\":\"Elongin-A\",\"id\":\"Q14241\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"FACT complex subunit SPT16\",\"id\":\"Q9Y5B9\"},{\"label\":\"FACT complex subunit SSRP1\",\"id\":\"Q08945\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIE subunit 1\",\"id\":\"P29083\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Negative elongation factor A\",\"id\":\"Q9H3P2\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"},{\"label\":\"Negative elongation factor C/D\",\"id\":\"Q8IXH7\"},{\"label\":\"Negative elongation factor E\",\"id\":\"P18615\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Parafibromin\",\"id\":\"Q6P1J9\"},{\"label\":\"Protein AF-9\",\"id\":\"P42568\"},{\"label\":\"Protein ENL\",\"id\":\"Q03111\"},{\"label\":\"Protein IWS1 homolog\",\"id\":\"Q96ST2\"},{\"label\":\"RNA polymerase II elongation factor ELL\",\"id\":\"P55199\"},{\"label\":\"RNA polymerase II subunit A C-terminal domain phosphatase\",\"id\":\"Q9Y5B0\"},{\"label\":\"RNA polymerase II-associated factor 1 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7\",\"id\":\"Q99497\"},{\"label\":\"Pericentrin\",\"id\":\"O95613\"},{\"label\":\"Perilipin-2\",\"id\":\"Q99541\"},{\"label\":\"Perilipin-3\",\"id\":\"O60664\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Ribonuclease pancreatic\",\"id\":\"P07998\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O60664\",\"O95613\",\"P07900\",\"P07998\",\"P08238\",\"P0CG47\",\"P0CG48\",\"P11142\",\"P13473\",\"P13569\",\"P14136\",\"P62979\",\"P62987\",\"P68104\",\"P68871\",\"Q12798\",\"Q13099\",\"Q3SXY8\",\"Q99497\",\"Q99541\",\"Q9UBN7\"]", "gene_symbol": 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thrombospondin motifs 5\",\"id\":\"Q9UNA0\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 8\",\"id\":\"Q9UP79\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 9\",\"id\":\"Q9P2N4\"},{\"label\":\"Aggrecan core protein\",\"id\":\"P16112\"},{\"label\":\"Alpha-2-macroglobulin\",\"id\":\"P01023\"},{\"label\":\"Basement membrane-specific heparan sulfate proteoglycan core protein\",\"id\":\"P98160\"},{\"label\":\"Basigin\",\"id\":\"P35613\"},{\"label\":\"Bone morphogenetic protein 1\",\"id\":\"P13497\"},{\"label\":\"Brevican core protein\",\"id\":\"Q96GW7\"},{\"label\":\"CD44 antigen\",\"id\":\"P16070\"},{\"label\":\"Cadherin-1\",\"id\":\"P12830\"},{\"label\":\"Calpain small subunit 1\",\"id\":\"P04632\"},{\"label\":\"Calpain small subunit 2\",\"id\":\"Q96L46\"},{\"label\":\"Calpain-1 catalytic 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4\",\"id\":\"P78352\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 1\",\"id\":\"Q05586\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2A\",\"id\":\"Q12879\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2C\",\"id\":\"Q14957\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2D\",\"id\":\"O15399\"},{\"label\":\"Leucine-rich repeat-containing protein 7\",\"id\":\"Q96NW7\"},{\"label\":\"Neurofilament light polypeptide\",\"id\":\"P07196\"},{\"label\":\"Protein phosphatase 1E\",\"id\":\"Q8WY54\"},{\"label\":\"Protein phosphatase 1F\",\"id\":\"P49593\"}]", "uniprot_id": "[\"O15399\",\"P07196\",\"P0DP23\",\"P35609\",\"P49593\",\"P78352\",\"Q05586\",\"Q12879\",\"Q12959\",\"Q13224\",\"Q13554\",\"Q13555\",\"Q13557\",\"Q14012\",\"Q14957\",\"Q15700\",\"Q16566\",\"Q8WY54\",\"Q92796\",\"Q96NW7\",\"Q9UQM7\"]", "gene_symbol": 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"[\"HOHO1\",\"IRK1\",\"IRK2\",\"IRK3\",\"IRK4\",\"KCNJ12\",\"KCNJ14\",\"KCNJ2\",\"KCNJ4\",\"KCNJN1\",\"KCNK1\",\"KCNK10\",\"KCNK12\",\"KCNK13\",\"KCNK15\",\"KCNK16\",\"KCNK17\",\"KCNK18\",\"KCNK2\",\"KCNK3\",\"KCNK4\",\"KCNK5\",\"KCNK6\",\"KCNK7\",\"KCNK9\",\"KCNO1\",\"TALK1\",\"TALK2\",\"TASK\",\"TASK1\",\"TASK2\",\"TASK3\",\"TASK4\",\"TASK5\",\"TOSS\",\"TRAAK\",\"TREK\",\"TREK1\",\"TREK2\",\"TRESK\",\"TRIK\",\"TWIK1\",\"TWIK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX3 regulates YAP1-mediated transcription", "protein_name": "[{\"label\":\"CCN family member 2\",\"id\":\"P29279\"},{\"label\":\"Runt-related transcription factor 3\",\"id\":\"Q13761\"},{\"label\":\"Transcriptional coactivator YAP1\",\"id\":\"P46937\"},{\"label\":\"Transcriptional enhancer factor TEF-1\",\"id\":\"P28347\"},{\"label\":\"Transcriptional enhancer factor TEF-3\",\"id\":\"Q15561\"},{\"label\":\"Transcriptional enhancer factor TEF-4\",\"id\":\"Q15562\"},{\"label\":\"Transcriptional enhancer factor 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KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Mastermind-like domain-containing protein 1\",\"id\":\"Q13495\"},{\"label\":\"Mastermind-like protein 1\",\"id\":\"Q92585\"},{\"label\":\"Mastermind-like protein 2\",\"id\":\"Q8IZL2\"},{\"label\":\"Mastermind-like protein 3\",\"id\":\"Q96JK9\"},{\"label\":\"Mothers against decapentaplegic homolog 3\",\"id\":\"P84022\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Neurogenic locus notch homolog protein 2\",\"id\":\"Q04721\"},{\"label\":\"Neurogenic locus notch homolog protein 4\",\"id\":\"Q99466\"},{\"label\":\"Recombining binding protein suppressor of hairless\",\"id\":\"Q06330\"},{\"label\":\"SNW domain-containing protein 1\",\"id\":\"Q13573\"},{\"label\":\"Transcription factor HES-1\",\"id\":\"Q14469\"},{\"label\":\"Transcription factor HES-5\",\"id\":\"Q5TA89\"},{\"label\":\"Vascular endothelial growth factor receptor 3\",\"id\":\"P35916\"}]", "uniprot_id": "[\"P35916\",\"P46531\",\"P62736\",\"P84022\",\"Q04721\",\"Q06330\",\"Q09472\",\"Q13495\",\"Q13573\",\"Q14469\",\"Q5TA89\",\"Q8IZL2\",\"Q92585\",\"Q92793\",\"Q92830\",\"Q92831\",\"Q96JK9\",\"Q99466\",\"Q9UBP5\",\"Q9Y5J3\"]", "gene_symbol": "[\"ACTA2\",\"ACTSA\",\"ACTVS\",\"BHLHB31\",\"BHLHB32\",\"BHLHB38\",\"BHLHB39\",\"CBP\",\"CG1\",\"CHF1\",\"CHF2\",\"CREBBP\",\"CXorf6\",\"EP300\",\"FLT4\",\"GCN5\",\"GCN5L2\",\"GRL\",\"HERP\",\"HERP1\",\"HERP2\",\"HES1\",\"HES5\",\"HESR1\",\"HEY1\",\"HEY2\",\"HL\",\"HRT1\",\"HRT2\",\"HRY\",\"IGKJRB\",\"IGKJRB1\",\"INT3\",\"KAT2A\",\"KAT2B\",\"KIAA0200\",\"KIAA1816\",\"KIAA1819\",\"MADH3\",\"MAML1\",\"MAML2\",\"MAML3\",\"MAMLD1\",\"NOTCH1\",\"NOTCH2\",\"NOTCH4\",\"P300\",\"PCAF\",\"RBPJ\",\"RBPJK\",\"RBPSUH\",\"SKIIP\",\"SKIP\",\"SMAD3\",\"SNW1\",\"TAN1\",\"VEGFR3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Endogenous sterols", "protein_name": "[{\"label\":\"24-hydroxycholesterol 7-alpha-hydroxylase\",\"id\":\"Q9NYL5\"},{\"label\":\"Adrenodoxin, mitochondrial\",\"id\":\"P10109\"},{\"label\":\"Aromatase\",\"id\":\"P11511\"},{\"label\":\"Aryl hydrocarbon receptor nuclear translocator 2\",\"id\":\"Q9HBZ2\"},{\"label\":\"Aryl hydrocarbon receptor nuclear translocator\",\"id\":\"P27540\"},{\"label\":\"Aryl hydrocarbon receptor repressor\",\"id\":\"A9YTQ3\"},{\"label\":\"Aryl hydrocarbon receptor\",\"id\":\"P35869\"},{\"label\":\"Bile acid receptor\",\"id\":\"Q96RI1\"},{\"label\":\"Cholesterol 24-hydroxylase\",\"id\":\"Q9Y6A2\"},{\"label\":\"Cholesterol side-chain cleavage enzyme, mitochondrial\",\"id\":\"P05108\"},{\"label\":\"Cytochrome P450 11B1, mitochondrial\",\"id\":\"P15538\"},{\"label\":\"Cytochrome P450 11B2, mitochondrial\",\"id\":\"P19099\"},{\"label\":\"Cytochrome P450 1B1\",\"id\":\"Q16678\"},{\"label\":\"Cytochrome P450 4V2\",\"id\":\"Q6ZWL3\"},{\"label\":\"Cytochrome P450 7A1\",\"id\":\"P22680\"},{\"label\":\"Cytochrome P450 7B1\",\"id\":\"O75881\"},{\"label\":\"Ferredoxin-2, mitochondrial\",\"id\":\"Q6P4F2\"},{\"label\":\"Lanosterol 14-alpha demethylase\",\"id\":\"Q16850\"},{\"label\":\"NADPH\",\"id\":\"adrenodoxin oxidoreductase, mitochondrial:P22570\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Pro-opiomelanocortin\",\"id\":\"P01189\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Steroid 21-hydroxylase\",\"id\":\"P08686\"},{\"label\":\"Sterol 26-hydroxylase, mitochondrial\",\"id\":\"Q02318\"}]", "uniprot_id": "[\"A9YTQ3\",\"O75881\",\"P01189\",\"P05108\",\"P08686\",\"P10109\",\"P11511\",\"P15538\",\"P19099\",\"P19793\",\"P22570\",\"P22680\",\"P27540\",\"P35869\",\"Q02318\",\"Q15596\",\"Q15788\",\"Q16678\",\"Q16850\",\"Q6P4F2\",\"Q6ZWL3\",\"Q96RI1\",\"Q9HBZ2\",\"Q9NYL5\",\"Q9Y6A2\"]", "gene_symbol": "[\"ADX\",\"ADXR\",\"AHR\",\"AHRR\",\"ARNT\",\"ARNT2\",\"ARO1\",\"BAR\",\"BHLHE1\",\"BHLHE2\",\"BHLHE74\",\"BHLHE75\",\"BHLHE76\",\"BHLHE77\",\"CYAR\",\"CYP11A\",\"CYP11A1\",\"CYP11B1\",\"CYP11B2\",\"CYP19\",\"CYP19A1\",\"CYP1B1\",\"CYP21\",\"CYP21A2\",\"CYP21B\",\"CYP27\",\"CYP27A1\",\"CYP39A1\",\"CYP46\",\"CYP46A1\",\"CYP4V2\",\"CYP51\",\"CYP51A1\",\"CYP7\",\"CYP7A1\",\"CYP7B1\",\"FDX1\",\"FDX1L\",\"FDX2\",\"FDXR\",\"FXR\",\"HRR1\",\"KIAA0307\",\"KIAA1234\",\"NCOA1\",\"NCOA2\",\"NR1H4\",\"NR2B1\",\"POMC\",\"RIP14\",\"RXRA\",\"S11BH\",\"SRC1\",\"SRC2\",\"TIF2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Release of Hh-Np from the secreting cell", "protein_name": "[{\"label\":\"Desert hedgehog protein\",\"id\":\"O43323\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 17\",\"id\":\"P78536\"},{\"label\":\"Glypican-5\",\"id\":\"P78333\"},{\"label\":\"Indian hedgehog protein\",\"id\":\"Q14623\"},{\"label\":\"Palmitoleoyl-protein carboxylesterase NOTUM\",\"id\":\"Q6P988\"},{\"label\":\"Protein dispatched homolog 2\",\"id\":\"A7MBM2\"},{\"label\":\"Signal peptide, CUB and EGF-like domain-containing protein 2\",\"id\":\"Q9NQ36\"},{\"label\":\"Sonic hedgehog protein\",\"id\":\"Q15465\"}]", "uniprot_id": "[\"A7MBM2\",\"O43323\",\"P78333\",\"P78536\",\"Q14623\",\"Q15465\",\"Q6P988\",\"Q9NQ36\"]", "gene_symbol": "[\"ADAM17\",\"C15orf36\",\"CEGP1\",\"CSVP\",\"DHH\",\"DISP2\",\"DISPB\",\"GPC5\",\"IHH\",\"KIAA1742\",\"LINC00594\",\"NOTUM\",\"SCUBE2\",\"SHH\",\"TACE\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ARMS-mediated activation", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"Adapter molecule crk\",\"id\":\"P46108\"},{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"High affinity nerve growth factor receptor\",\"id\":\"P04629\"},{\"label\":\"Kinase D-interacting substrate of 220 kDa\",\"id\":\"Q9ULH0\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"}]", "uniprot_id": "[\"P01138\",\"P04629\",\"P15056\",\"P31946\",\"P46108\",\"P62834\",\"Q9ULH0\"]", "gene_symbol": "[\"ARMS\",\"BRAF\",\"BRAF1\",\"CRK\",\"KIAA1250\",\"KIDINS220\",\"KREV1\",\"MTC\",\"NGF\",\"NGFB\",\"NTRK1\",\"RAFB1\",\"RAP1A\",\"TRK\",\"TRKA\",\"YWHAB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Alpha-oxidation of phytanate", "protein_name": "[{\"label\":\"2-hydroxyacyl-CoA lyase 1\",\"id\":\"Q9UJ83\"},{\"label\":\"Long-chain fatty acid transport protein 2\",\"id\":\"O14975\"},{\"label\":\"Peroxisomal membrane protein PMP34\",\"id\":\"O43808\"},{\"label\":\"Peroxisomal trans-2-enoyl-CoA reductase\",\"id\":\"Q9BY49\"},{\"label\":\"Phytanoyl-CoA dioxygenase, peroxisomal\",\"id\":\"O14832\"}]", "uniprot_id": "[\"O14832\",\"O14975\",\"O43808\",\"Q9BY49\",\"Q9UJ83\"]", "gene_symbol": 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proliferator-activated receptor gamma\",\"id\":\"Q96EK7\"},{\"label\":\"Cyclin-C\",\"id\":\"P24863\"},{\"label\":\"Cyclin-dependent kinase 19\",\"id\":\"Q9BWU1\"},{\"label\":\"Cyclin-dependent kinase 4\",\"id\":\"P11802\"},{\"label\":\"Cyclin-dependent kinase 8\",\"id\":\"P49336\"},{\"label\":\"E3 SUMO-protein ligase EGR2\",\"id\":\"P11161\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Fatty acid-binding protein, adipocyte\",\"id\":\"P15090\"},{\"label\":\"G1/S-specific cyclin-D3\",\"id\":\"P30281\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone-arginine methyltransferase CARM1\",\"id\":\"Q86X55\"},{\"label\":\"Krueppel-like factor 4\",\"id\":\"O43474\"},{\"label\":\"Krueppel-like factor 5\",\"id\":\"Q13887\"},{\"label\":\"Leptin\",\"id\":\"P41159\"},{\"label\":\"Lipoprotein lipase\",\"id\":\"P06858\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 10\",\"id\":\"Q9BTT4\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 11\",\"id\":\"Q9P086\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 12\",\"id\":\"Q93074\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 13-like\",\"id\":\"Q71F56\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 13\",\"id\":\"Q9UHV7\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 14\",\"id\":\"O60244\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 15\",\"id\":\"Q96RN5\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 16\",\"id\":\"Q9Y2X0\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 17\",\"id\":\"Q9NVC6\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 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"gtc_id": "[\"\"]" }, { "pathway_label": "Beta oxidation of octanoyl-CoA to hexanoyl-CoA", "protein_name": "[{\"label\":\"Enoyl-CoA hydratase, mitochondrial\",\"id\":\"P30084\"},{\"label\":\"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial\",\"id\":\"Q16836\"},{\"label\":\"Medium-chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P11310\"},{\"label\":\"Trifunctional enzyme subunit alpha, mitochondrial\",\"id\":\"P40939\"},{\"label\":\"Trifunctional enzyme subunit beta, mitochondrial\",\"id\":\"P55084\"}]", "uniprot_id": "[\"P11310\",\"P30084\",\"P40939\",\"P55084\",\"Q16836\"]", "gene_symbol": "[\"ACADM\",\"ECHS1\",\"HAD\",\"HAD1\",\"HADH\",\"HADHA\",\"HADHB\",\"HADHSC\",\"SCHAD\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NCAM1 interactions", "protein_name": "[{\"label\":\"Agrin\",\"id\":\"O00468\"},{\"label\":\"Alpha-2,8-sialyltransferase 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"gtc_id": "[\"\"]" }, { "pathway_label": "Resistance of ERBB2 KD mutants to neratinib", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P04626\",\"P07900\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Detoxification of Reactive Oxygen Species", "protein_name": "[{\"label\":\"Aquaporin-8\",\"id\":\"O94778\"},{\"label\":\"Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]\",\"id\":\"P50583\"},{\"label\":\"Catalase\",\"id\":\"P04040\"},{\"label\":\"Copper chaperone for superoxide dismutase\",\"id\":\"O14618\"},{\"label\":\"Copper transport protein 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1\",\"id\":\"P14598\"},{\"label\":\"Neutrophil cytosol factor 2\",\"id\":\"P19878\"},{\"label\":\"Neutrophil cytosol factor 4\",\"id\":\"Q15080\"},{\"label\":\"Peroxiredoxin-1\",\"id\":\"Q06830\"},{\"label\":\"Peroxiredoxin-2\",\"id\":\"P32119\"},{\"label\":\"Peroxiredoxin-6\",\"id\":\"P30041\"},{\"label\":\"Probable glutathione peroxidase 8\",\"id\":\"Q8TED1\"},{\"label\":\"Protein disulfide-isomerase\",\"id\":\"P07237\"},{\"label\":\"Superoxide dismutase [Cu-Zn]\",\"id\":\"P00441\"},{\"label\":\"Superoxide dismutase [Mn], mitochondrial\",\"id\":\"P04179\"},{\"label\":\"Thioredoxin reductase 1, cytoplasmic\",\"id\":\"Q16881\"},{\"label\":\"Thioredoxin reductase 2, mitochondrial\",\"id\":\"Q9NNW7\"},{\"label\":\"Thioredoxin, mitochondrial\",\"id\":\"Q99757\"},{\"label\":\"Thioredoxin-dependent peroxide reductase, mitochondrial\",\"id\":\"P30048\"},{\"label\":\"Thioredoxin\",\"id\":\"P10599\"}]", "uniprot_id": 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1\",\"id\":\"Q13546\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 3\",\"id\":\"Q9Y572\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"}]", "uniprot_id": "[\"O15455\",\"Q13158\",\"Q13546\",\"Q14790\",\"Q8IUC6\",\"Q9Y572\"]", "gene_symbol": "[\"CASP8\",\"FADD\",\"MCH5\",\"MORT1\",\"PRVTIRB\",\"RIP\",\"RIP1\",\"RIP3\",\"RIPK1\",\"RIPK3\",\"TICAM1\",\"TLR3\",\"TRIF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Chromatin modifications during the maternal to zygotic transition (MZT)", "protein_name": "[{\"label\":\"Developmental pluripotency-associated protein 3\",\"id\":\"Q6W0C5\"},{\"label\":\"E3 ubiquitin-protein ligase UHRF1\",\"id\":\"Q96T88\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 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2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H3.3\",\"id\":\"P84243\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Histone-arginine methyltransferase METTL23\",\"id\":\"Q86XA0\"},{\"label\":\"Lysine-specific demethylase 5A\",\"id\":\"P29375\"},{\"label\":\"Lysine-specific demethylase 5B\",\"id\":\"Q9UGL1\"},{\"label\":\"Lysine-specific demethylase 6A\",\"id\":\"O15550\"},{\"label\":\"Lysine-specific demethylase 6B\",\"id\":\"O15054\"},{\"label\":\"Methylcytosine dioxygenase TET3\",\"id\":\"O43151\"},{\"label\":\"Protein STPG4\",\"id\":\"Q8N801\"},{\"label\":\"Single-stranded DNA cytosine deaminase\",\"id\":\"Q9GZX7\"},{\"label\":\"Uracil-DNA glycosylase\",\"id\":\"P13051\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Citric acid cycle (TCA cycle)", "protein_name": "[{\"label\":\"Aconitate hydratase, mitochondrial\",\"id\":\"Q99798\"},{\"label\":\"Citrate synthase, mitochondrial\",\"id\":\"O75390\"},{\"label\":\"Fumarate hydratase, mitochondrial\",\"id\":\"P07954\"},{\"label\":\"Heat shock protein 75 kDa, mitochondrial\",\"id\":\"Q12931\"},{\"label\":\"Isocitrate dehydrogenase [NADP], mitochondrial\",\"id\":\"P48735\"},{\"label\":\"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial\",\"id\":\"P50213\"},{\"label\":\"Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial\",\"id\":\"O43837\"},{\"label\":\"Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial\",\"id\":\"P51553\"},{\"label\":\"Malate dehydrogenase, mitochondrial\",\"id\":\"P40926\"},{\"label\":\"NAD(P) transhydrogenase, mitochondrial\",\"id\":\"Q13423\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial\",\"id\":\"O14521\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial\",\"id\":\"P31040\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial\",\"id\":\"P21912\"},{\"label\":\"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial\",\"id\":\"Q99643\"},{\"label\":\"Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial\",\"id\":\"Q9P2R7\"},{\"label\":\"Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial\",\"id\":\"P53597\"},{\"label\":\"Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial\",\"id\":\"Q96I99\"}]", "uniprot_id": "[\"O14521\",\"O43837\",\"O75390\",\"P07954\",\"P21912\",\"P31040\",\"P40926\",\"P48735\",\"P50213\",\"P51553\",\"P53597\",\"Q12931\",\"Q13423\",\"Q96I99\",\"Q99643\",\"Q99798\",\"Q9P2R7\"]", "gene_symbol": "[\"ACO2\",\"CS\",\"CYB560\",\"FH\",\"HSP75\",\"HSPC5\",\"IDH2\",\"IDH3A\",\"IDH3B\",\"IDH3G\",\"MDH2\",\"NNT\",\"SDH\",\"SDH1\",\"SDH2\",\"SDH3\",\"SDH4\",\"SDHA\",\"SDHB\",\"SDHC\",\"SDHD\",\"SDHF\",\"SUCLA2\",\"SUCLG1\",\"SUCLG2\",\"TRAP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Platelet Adhesion to exposed collagen", "protein_name": "[{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 13\",\"id\":\"Q76LX8\"},{\"label\":\"High affinity immunoglobulin epsilon receptor subunit gamma\",\"id\":\"P30273\"},{\"label\":\"Integrin alpha-10\",\"id\":\"O75578\"},{\"label\":\"Integrin alpha-1\",\"id\":\"P56199\"},{\"label\":\"Integrin alpha-2\",\"id\":\"P17301\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Platelet glycoprotein IX\",\"id\":\"P14770\"},{\"label\":\"Platelet glycoprotein Ib alpha chain\",\"id\":\"P07359\"},{\"label\":\"Platelet glycoprotein Ib beta chain\",\"id\":\"P13224\"},{\"label\":\"Platelet glycoprotein V\",\"id\":\"P40197\"},{\"label\":\"Platelet glycoprotein VI\",\"id\":\"Q9HCN6\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"O75578\",\"P04275\",\"P05556\",\"P06241\",\"P07359\",\"P07948\",\"P13224\",\"P14770\",\"P17301\",\"P30273\",\"P40197\",\"P56199\",\"Q76LX8\",\"Q9HCN6\"]", "gene_symbol": "[\"ADAMTS13\",\"C9orf8\",\"CD49B\",\"F8VWF\",\"FCER1G\",\"FNRB\",\"FYN\",\"GP1BA\",\"GP1BB\",\"GP5\",\"GP6\",\"GP9\",\"ITGA1\",\"ITGA10\",\"ITGA2\",\"ITGB1\",\"JTK8\",\"LYN\",\"MDF2\",\"MSK12\",\"VWF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SERPING1 causes hereditary angioedema", "protein_name": "[{\"label\":\"Coagulation factor XII\",\"id\":\"P00748\"},{\"label\":\"Plasma kallikrein\",\"id\":\"P03952\"},{\"label\":\"Plasma protease C1 inhibitor\",\"id\":\"P05155\"}]", "uniprot_id": "[\"P00748\",\"P03952\",\"P05155\"]", "gene_symbol": "[\"C1IN\",\"C1NH\",\"F12\",\"KLK3\",\"KLKB1\",\"SERPING1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transcriptional regulation of pluripotent stem cells", "protein_name": "[{\"label\":\"Endothelial PAS domain-containing protein 1\",\"id\":\"Q99814\"},{\"label\":\"Homeobox protein NANOG\",\"id\":\"Q9H9S0\"},{\"label\":\"Hypoxia-inducible factor 3-alpha\",\"id\":\"Q9Y2N7\"},{\"label\":\"Krueppel-like factor 4\",\"id\":\"O43474\"},{\"label\":\"Mothers against decapentaplegic homolog 2\",\"id\":\"Q15796\"},{\"label\":\"Mothers against decapentaplegic homolog 4\",\"id\":\"Q13485\"},{\"label\":\"POU domain, class 5, transcription factor 1\",\"id\":\"Q01860\"},{\"label\":\"PR domain zinc finger protein 14\",\"id\":\"Q9GZV8\"},{\"label\":\"Pre-B-cell leukemia transcription factor 1\",\"id\":\"P40424\"},{\"label\":\"Protein lin-28 homolog A\",\"id\":\"Q9H9Z2\"},{\"label\":\"Sal-like protein 4\",\"id\":\"Q9UJQ4\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Steroidogenic factor 1\",\"id\":\"Q13285\"},{\"label\":\"Transcription factor SOX-2\",\"id\":\"P48431\"},{\"label\":\"Zinc finger and SCAN domain-containing protein 10\",\"id\":\"Q96SZ4\"},{\"label\":\"Zinc finger protein ZIC 3\",\"id\":\"O60481\"}]", "uniprot_id": "[\"O43474\",\"O60481\",\"P40424\",\"P40763\",\"P48431\",\"Q01860\",\"Q13285\",\"Q13485\",\"Q15796\",\"Q96SZ4\",\"Q99814\",\"Q9GZV8\",\"Q9H9S0\",\"Q9H9Z2\",\"Q9UJQ4\",\"Q9Y2N7\"]", "gene_symbol": "[\"AD4BP\",\"APRF\",\"BHLHE17\",\"BHLHE73\",\"CSDD1\",\"DPC4\",\"EPAS1\",\"EZF\",\"FTZF1\",\"GKLF\",\"HIF2A\",\"HIF3A\",\"KLF4\",\"LIN28\",\"LIN28A\",\"MADH2\",\"MADH4\",\"MADR2\",\"MOP2\",\"MOP7\",\"NANOG\",\"NR5A1\",\"OCT3\",\"OCT4\",\"OTF3\",\"PASD2\",\"PASD7\",\"PBX1\",\"POU5F1\",\"PRDM14\",\"PRL\",\"SALL4\",\"SF1\",\"SMAD2\",\"SMAD4\",\"SOX2\",\"STAT3\",\"ZCCHC1\",\"ZIC3\",\"ZNF203\",\"ZNF206\",\"ZNF797\",\"ZSCAN10\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Atorvastatin ADME", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 2\",\"id\":\"Q92887\"},{\"label\":\"ATP-dependent translocase ABCB1\",\"id\":\"P08183\"},{\"label\":\"Cytochrome P450 3A4\",\"id\":\"P08684\"},{\"label\":\"Serum paraoxonase/arylesterase 1\",\"id\":\"P27169\"},{\"label\":\"Serum paraoxonase/lactonase 3\",\"id\":\"Q15166\"},{\"label\":\"Solute carrier organic anion transporter family member 1B1\",\"id\":\"Q9Y6L6\"},{\"label\":\"Solute carrier organic anion transporter family member 1B3\",\"id\":\"Q9NPD5\"},{\"label\":\"UDP-glucuronosyltransferase 1A3\",\"id\":\"P35503\"}]", "uniprot_id": "[\"P08183\",\"P08684\",\"P27169\",\"P35503\",\"Q15166\",\"Q92887\",\"Q9NPD5\",\"Q9Y6L6\"]", "gene_symbol": 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RPC7-like\",\"id\":\"Q9BT43\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC7\",\"id\":\"O15318\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC8\",\"id\":\"Q9Y535\"},{\"label\":\"DNA-directed RNA polymerase III subunit RPC9\",\"id\":\"O75575\"},{\"label\":\"DNA-directed RNA polymerases I and III subunit RPAC1\",\"id\":\"O15160\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"Protein POLR1D, isoform 2\",\"id\":\"P0DPB5\"}]", "uniprot_id": "[\"O14802\",\"O15160\",\"O15318\",\"O75575\",\"P05423\",\"P0DPB5\",\"P19388\",\"P52434\",\"P53803\",\"P61218\",\"P62875\",\"Q9BT43\",\"Q9BUI4\",\"Q9H1D9\",\"Q9NVU0\",\"Q9NW08\",\"Q9Y2Y1\",\"Q9Y535\"]", "gene_symbol": "[\"BN51\",\"BN51T\",\"CRCP\",\"KIAA1452\",\"KIAA1665\",\"POLR1C\",\"POLR1D\",\"POLR1E\",\"POLR2E\",\"POLR2F\",\"POLR2H\",\"POLR2K\",\"POLR2L\",\"POLR3A\",\"POLR3B\",\"POLR3C\",\"POLR3D\",\"POLR3E\",\"POLR3F\",\"POLR3G\",\"POLR3GL\",\"POLR3H\",\"POLR3K\",\"POLRF\",\"RPC11\",\"RPC8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Dectin-2 family", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2\",\"id\":\"P16885\"},{\"label\":\"C-type lectin domain family 10 member A\",\"id\":\"Q8IUN9\"},{\"label\":\"C-type lectin domain family 4 member A\",\"id\":\"Q9UMR7\"},{\"label\":\"C-type lectin domain family 4 member C\",\"id\":\"Q8WTT0\"},{\"label\":\"C-type lectin domain family 4 member D\",\"id\":\"Q8WXI8\"},{\"label\":\"C-type lectin domain family 4 member E\",\"id\":\"Q9ULY5\"},{\"label\":\"C-type lectin domain family 6 member A\",\"id\":\"Q6EIG7\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P03375\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P03377\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P03378\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04578\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04579\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04580\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04581\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04582\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04583\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P04624\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P05877\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P05878\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P05879\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P05880\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P05881\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P05882\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P12487\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P12488\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P12489\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P18799\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P19549\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P19550\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P19551\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P20871\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P20888\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P31819\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P31872\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"P35961\"},{\"label\":\"Envelope glycoprotein gp160\",\"id\":\"Q70626\"},{\"label\":\"Genome 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"gtc_id": "[\"\"]" }, { "pathway_label": "Glyoxylate metabolism and glycine degradation", "protein_name": "[{\"label\":\"2-Hydroxyacid oxidase 1\",\"id\":\"Q9UJM8\"},{\"label\":\"4-hydroxy-2-oxoglutarate aldolase, mitochondrial\",\"id\":\"Q86XE5\"},{\"label\":\"Alanine--glyoxylate aminotransferase 2, mitochondrial\",\"id\":\"Q9BYV1\"},{\"label\":\"Alanine--glyoxylate aminotransferase\",\"id\":\"P21549\"},{\"label\":\"Aspartate aminotransferase, mitochondrial\",\"id\":\"P00505\"},{\"label\":\"D-amino-acid oxidase\",\"id\":\"P14920\"},{\"label\":\"D-aspartate oxidase\",\"id\":\"Q99489\"},{\"label\":\"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial\",\"id\":\"P30038\"},{\"label\":\"Glycine N-methyltransferase\",\"id\":\"Q14749\"},{\"label\":\"Glyoxylate reductase/hydroxypyruvate reductase\",\"id\":\"Q9UBQ7\"},{\"label\":\"Hydroxyproline dehydrogenase\",\"id\":\"Q9UF12\"},{\"label\":\"Peroxisomal membrane protein 2\",\"id\":\"Q9NR77\"}]", "uniprot_id": "[\"P00505\",\"P14920\",\"P21549\",\"P30038\",\"Q14749\",\"Q86XE5\",\"Q99489\",\"Q9BYV1\",\"Q9NR77\",\"Q9UBQ7\",\"Q9UF12\",\"Q9UJM8\"]", "gene_symbol": "[\"AGT1\",\"AGT2\",\"AGXT\",\"AGXT2\",\"ALDH4\",\"ALDH4A1\",\"C10orf65\",\"DAMOX\",\"DAO\",\"DDO\",\"DHDPSL\",\"GLXR\",\"GNMT\",\"GOT2\",\"GOX1\",\"GRHPR\",\"HAO1\",\"HOGA1\",\"HSPOX1\",\"HYPDH\",\"KYAT4\",\"P5CDH\",\"PMP22\",\"PRODH2\",\"PXMP2\",\"SPAT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Drug-mediated inhibition of MET activation", "protein_name": "[{\"label\":\"Hepatocyte growth factor receptor\",\"id\":\"P08581\"},{\"label\":\"Hepatocyte growth factor\",\"id\":\"P14210\"}]", "uniprot_id": "[\"P08581\",\"P14210\"]", "gene_symbol": "[\"HGF\",\"HPTA\",\"MET\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Catecholamine biosynthesis", "protein_name": "[{\"label\":\"Aromatic-L-amino-acid decarboxylase\",\"id\":\"P20711\"},{\"label\":\"Dopamine beta-hydroxylase\",\"id\":\"P09172\"},{\"label\":\"Phenylethanolamine N-methyltransferase\",\"id\":\"P11086\"},{\"label\":\"Tyrosine 3-monooxygenase\",\"id\":\"P07101\"}]", "uniprot_id": "[\"P07101\",\"P09172\",\"P11086\",\"P20711\"]", "gene_symbol": "[\"AADC\",\"DBH\",\"DDC\",\"PENT\",\"PNMT\",\"TH\",\"TYH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Neurofascin interactions", "protein_name": "[{\"label\":\"Ankyrin-1\",\"id\":\"P16157\"},{\"label\":\"Contactin-1\",\"id\":\"Q12860\"},{\"label\":\"Contactin-associated protein 1\",\"id\":\"P78357\"},{\"label\":\"Neurofascin\",\"id\":\"O94856\"},{\"label\":\"Neuronal cell adhesion molecule\",\"id\":\"Q92823\"},{\"label\":\"Neuronal migration protein doublecortin\",\"id\":\"O43602\"},{\"label\":\"Syntenin-1\",\"id\":\"O00560\"}]", "uniprot_id": "[\"O00560\",\"O43602\",\"O94856\",\"P16157\",\"P78357\",\"Q12860\",\"Q92823\"]", "gene_symbol": "[\"ANK\",\"ANK1\",\"CASPR\",\"CNTN1\",\"CNTNAP1\",\"DBCN\",\"DCX\",\"KIAA0343\",\"KIAA0756\",\"LISX\",\"MDA9\",\"NFASC\",\"NRCAM\",\"NRXN4\",\"SDCBP\",\"SYCL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective B3GALT6 causes EDSP2 and SEMDJL1", "protein_name": "[{\"label\":\"Agrin\",\"id\":\"O00468\"},{\"label\":\"Basement membrane-specific heparan sulfate proteoglycan core protein\",\"id\":\"P98160\"},{\"label\":\"Beta-1,3-galactosyltransferase 6\",\"id\":\"Q96L58\"},{\"label\":\"Biglycan\",\"id\":\"P21810\"},{\"label\":\"Brevican core protein\",\"id\":\"Q96GW7\"},{\"label\":\"Chondroitin sulfate proteoglycan 4\",\"id\":\"Q6UVK1\"},{\"label\":\"Chondroitin sulfate proteoglycan 5\",\"id\":\"O95196\"},{\"label\":\"Decorin\",\"id\":\"P07585\"},{\"label\":\"Glypican-1\",\"id\":\"P35052\"},{\"label\":\"Glypican-2\",\"id\":\"Q8N158\"},{\"label\":\"Glypican-3\",\"id\":\"P51654\"},{\"label\":\"Glypican-4\",\"id\":\"O75487\"},{\"label\":\"Glypican-5\",\"id\":\"P78333\"},{\"label\":\"Glypican-6\",\"id\":\"Q9Y625\"},{\"label\":\"Neurocan core protein\",\"id\":\"O14594\"},{\"label\":\"Syndecan-1\",\"id\":\"P18827\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Syndecan-3\",\"id\":\"O75056\"},{\"label\":\"Syndecan-4\",\"id\":\"P31431\"},{\"label\":\"Versican core protein\",\"id\":\"P13611\"}]", "uniprot_id": "[\"O00468\",\"O14594\",\"O75056\",\"O75487\",\"O95196\",\"P07585\",\"P13611\",\"P18827\",\"P21810\",\"P31431\",\"P34741\",\"P35052\",\"P51654\",\"P78333\",\"P98160\",\"Q6UVK1\",\"Q8N158\",\"Q96GW7\",\"Q96L58\",\"Q9Y625\"]", "gene_symbol": "[\"AGRIN\",\"AGRN\",\"B3GALT6\",\"BCAN\",\"BEHAB\",\"BGN\",\"CALEB\",\"CSPG2\",\"CSPG3\",\"CSPG4\",\"CSPG5\",\"CSPG7\",\"DCN\",\"GPC1\",\"GPC2\",\"GPC3\",\"GPC4\",\"GPC5\",\"GPC6\",\"HSPG1\",\"HSPG2\",\"KIAA0468\",\"MCSP\",\"NCAN\",\"NEUR\",\"NGC\",\"OCI5\",\"SDC\",\"SDC1\",\"SDC2\",\"SDC3\",\"SDC4\",\"SLRR1A\",\"SLRR1B\",\"VCAN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Impaired BRCA2 binding to RAD51", "protein_name": "[{\"label\":\"26S proteasome complex subunit 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C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"Serine/threonine-protein kinase ATR\",\"id\":\"Q13535\"}]", "uniprot_id": "[\"O60671\",\"O60921\",\"O60934\",\"O75943\",\"P15927\",\"P27694\",\"P35244\",\"P35249\",\"P35250\",\"P38398\",\"P40937\",\"P40938\",\"P49959\",\"P51530\",\"P51587\",\"P54132\",\"P60896\",\"Q06609\",\"Q13315\",\"Q13472\",\"Q13535\",\"Q14191\",\"Q6WBX8\",\"Q8WXE1\",\"Q92547\",\"Q92878\",\"Q92993\",\"Q96E14\",\"Q99638\",\"Q99708\",\"Q99728\",\"Q9BSD3\",\"Q9BX63\",\"Q9H9A7\",\"Q9UQ84\"]", "gene_symbol": 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3\",\"id\":\"Q8NEB9\"},{\"label\":\"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha\",\"id\":\"O00443\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2\",\"id\":\"Q13614\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4\",\"id\":\"Q9NYA4\"},{\"label\":\"Phosphatidylinositol-3-phosphate phosphatase MTMR7\",\"id\":\"Q9Y216\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 4\",\"id\":\"Q99570\"},{\"label\":\"Polyphosphoinositide phosphatase\",\"id\":\"Q92562\"},{\"label\":\"Protein VAC14 homolog\",\"id\":\"Q08AM6\"}]", "uniprot_id": "[\"O00443\",\"Q08AM6\",\"Q13496\",\"Q13614\",\"Q8NEB9\",\"Q92562\",\"Q96QG7\",\"Q99570\",\"Q9NYA4\",\"Q9Y216\",\"Q9Y2I7\"]", "gene_symbol": 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3\",\"id\":\"Q14653\"},{\"label\":\"Interferon-induced helicase C domain-containing protein 1\",\"id\":\"Q9BYX4\"},{\"label\":\"Mitochondrial antiviral-signaling protein\",\"id\":\"Q7Z434\"},{\"label\":\"Mitochondrial import receptor subunit TOM70\",\"id\":\"O94826\"},{\"label\":\"NLR family member X1\",\"id\":\"Q86UT6\"},{\"label\":\"Nucleoprotein\",\"id\":\"P0DTC9\"},{\"label\":\"ORF9b protein\",\"id\":\"P0DTD2\"},{\"label\":\"Protein NLRC5\",\"id\":\"Q86WI3\"},{\"label\":\"Serine/threonine-protein kinase TBK1\",\"id\":\"Q9UHD2\"},{\"label\":\"Triokinase/FMN cyclase\",\"id\":\"Q3LXA3\"},{\"label\":\"Ubiquitin-like modifier-activating enzyme 7\",\"id\":\"P41226\"},{\"label\":\"Ubiquitin-like protein ISG15\",\"id\":\"P05161\"},{\"label\":\"Ubiquitin/ISG15-conjugating enzyme E2 L6\",\"id\":\"O14933\"}]", "uniprot_id": 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Neurotransmitter Release Cycle", "protein_name": "[{\"label\":\"Amine oxidase [flavin-containing] A\",\"id\":\"P21397\"},{\"label\":\"Complexin-1\",\"id\":\"O14810\"},{\"label\":\"Liprin-alpha-1\",\"id\":\"Q13136\"},{\"label\":\"Liprin-alpha-2\",\"id\":\"O75334\"},{\"label\":\"Liprin-alpha-3\",\"id\":\"O75145\"},{\"label\":\"Liprin-alpha-4\",\"id\":\"O75335\"},{\"label\":\"Peripheral-type benzodiazepine receptor-associated protein 1\",\"id\":\"O95153\"},{\"label\":\"Protein unc-13 homolog B\",\"id\":\"O14795\"},{\"label\":\"Ras-related protein Rab-3A\",\"id\":\"P20336\"},{\"label\":\"Regulating synaptic membrane exocytosis protein 1\",\"id\":\"Q86UR5\"},{\"label\":\"Solute carrier family 22 member 1\",\"id\":\"O15245\"},{\"label\":\"Solute carrier family 22 member 2\",\"id\":\"O15244\"},{\"label\":\"Synaptic vesicular amine transporter\",\"id\":\"Q05940\"},{\"label\":\"Synaptosomal-associated protein 25\",\"id\":\"P60880\"},{\"label\":\"Synaptotagmin-1\",\"id\":\"P21579\"},{\"label\":\"Syntaxin-1A\",\"id\":\"Q16623\"},{\"label\":\"Vesicle-associated membrane protein 2\",\"id\":\"P63027\"}]", "uniprot_id": "[\"O14795\",\"O14810\",\"O15244\",\"O15245\",\"O75145\",\"O75334\",\"O75335\",\"O95153\",\"P20336\",\"P21397\",\"P21579\",\"P60880\",\"P63027\",\"Q05940\",\"Q13136\",\"Q16623\",\"Q86UR5\"]", "gene_symbol": "[\"BZRAP1\",\"CPLX1\",\"KIAA0340\",\"KIAA0612\",\"KIAA0654\",\"KIAA0897\",\"LIP1\",\"MAOA\",\"OCT1\",\"OCT2\",\"PPFIA1\",\"PPFIA2\",\"PPFIA3\",\"PPFIA4\",\"RAB3A\",\"RAB3IP2\",\"RBP1\",\"RIM1\",\"RIMBP1\",\"RIMS1\",\"SLC18A2\",\"SLC22A1\",\"SLC22A2\",\"SNAP\",\"SNAP25\",\"STX1\",\"STX1A\",\"SVMT\",\"SVP65\",\"SYB2\",\"SYT\",\"SYT1\",\"TSPOAP1\",\"UNC13\",\"UNC13B\",\"VAMP2\",\"VMAT2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nuclear Envelope Breakdown", "protein_name": "[{\"label\":\"Barrier-to-autointegration 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protein\",\"id\":\"P13611\"},{\"label\":\"Vitronectin\",\"id\":\"P04004\"}]", "uniprot_id": "[\"O00468\",\"O14594\",\"O15146\",\"O15230\",\"O15232\",\"O75096\",\"O95460\",\"P01137\",\"P04004\",\"P05106\",\"P05121\",\"P05556\",\"P06756\",\"P07585\",\"P07942\",\"P08514\",\"P09486\",\"P10600\",\"P10915\",\"P11047\",\"P13591\",\"P13611\",\"P16112\",\"P17301\",\"P18084\",\"P18564\",\"P20702\",\"P20849\",\"P21810\",\"P21815\",\"P21941\",\"P22105\",\"P24043\",\"P24821\",\"P25391\",\"P49747\",\"P51884\",\"P53708\",\"P55268\",\"P61812\",\"P98160\",\"Q06828\",\"Q13316\",\"Q13332\",\"Q13683\",\"Q13797\",\"Q14050\",\"Q14055\",\"Q14118\",\"Q16363\",\"Q16787\",\"Q92752\",\"Q96GW7\",\"Q9BXN1\",\"Q9NZW4\",\"Q9UQP3\"]", "gene_symbol": 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1\",\"id\":\"Q13547\"},{\"label\":\"Histone-lysine N-methyltransferase 2A\",\"id\":\"Q03164\"},{\"label\":\"Histone-lysine N-methyltransferase 2B\",\"id\":\"Q9UMN6\"},{\"label\":\"Histone-lysine N-methyltransferase 2C\",\"id\":\"Q8NEZ4\"},{\"label\":\"Histone-lysine N-methyltransferase 2D\",\"id\":\"O14686\"},{\"label\":\"Histone-lysine N-methyltransferase SETD1A\",\"id\":\"O15047\"},{\"label\":\"Histone-lysine N-methyltransferase SETD1B\",\"id\":\"Q9UPS6\"},{\"label\":\"Integrin alpha-IIb\",\"id\":\"P08514\"},{\"label\":\"Myosin regulatory light polypeptide 9\",\"id\":\"P24844\"},{\"label\":\"Nuclear receptor subfamily 4 group A member 3\",\"id\":\"Q92570\"},{\"label\":\"Paired amphipathic helix protein Sin3a\",\"id\":\"Q96ST3\"},{\"label\":\"Paired amphipathic helix protein Sin3b\",\"id\":\"O75182\"},{\"label\":\"Platelet factor 4\",\"id\":\"P02776\"},{\"label\":\"Platelet glycoprotein Ib alpha chain\",\"id\":\"P07359\"},{\"label\":\"Protein arginine N-methyltransferase 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective F9 secretion", "protein_name": "[{\"label\":\"Coagulation factor IX\",\"id\":\"P00740\"}]", "uniprot_id": "[\"P00740\"]", "gene_symbol": "[\"F9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Prostanoid ligand receptors", "protein_name": "[{\"label\":\"Prostacyclin receptor\",\"id\":\"P43119\"},{\"label\":\"Prostaglandin D2 receptor 2\",\"id\":\"Q9Y5Y4\"},{\"label\":\"Prostaglandin D2 receptor\",\"id\":\"Q13258\"},{\"label\":\"Prostaglandin E2 receptor EP1 subtype\",\"id\":\"P34995\"},{\"label\":\"Prostaglandin E2 receptor EP2 subtype\",\"id\":\"P43116\"},{\"label\":\"Prostaglandin E2 receptor EP3 subtype\",\"id\":\"P43115\"},{\"label\":\"Prostaglandin E2 receptor EP4 subtype\",\"id\":\"P35408\"},{\"label\":\"Prostaglandin F2-alpha receptor\",\"id\":\"P43088\"},{\"label\":\"Thromboxane A2 receptor\",\"id\":\"P21731\"}]", "uniprot_id": "[\"P21731\",\"P34995\",\"P35408\",\"P43088\",\"P43115\",\"P43116\",\"P43119\",\"Q13258\",\"Q9Y5Y4\"]", "gene_symbol": "[\"CRTH2\",\"DL1R\",\"GPR44\",\"PRIPR\",\"PTGDR\",\"PTGDR2\",\"PTGER1\",\"PTGER2\",\"PTGER3\",\"PTGER4\",\"PTGFR\",\"PTGIR\",\"TBXA2R\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mitochondrial ABC transporters", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family B member 10, mitochondrial\",\"id\":\"Q9NRK6\"},{\"label\":\"ATP-binding cassette sub-family B member 6\",\"id\":\"Q9NP58\"},{\"label\":\"Iron-sulfur clusters transporter ABCB7, mitochondrial\",\"id\":\"O75027\"},{\"label\":\"Mitochondrial potassium channel ATP-binding subunit\",\"id\":\"Q9NUT2\"}]", "uniprot_id": "[\"O75027\",\"Q9NP58\",\"Q9NRK6\",\"Q9NUT2\"]", "gene_symbol": "[\"ABC7\",\"ABCB10\",\"ABCB6\",\"ABCB7\",\"ABCB8\",\"MABC1\",\"MITOSUR\",\"MTABC3\",\"PRP\",\"UMAT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Intestinal infectious diseases", "protein_name": "[{\"label\":\"Guanylyl cyclase C\",\"id\":\"P25092\"},{\"label\":\"Heat-stable enterotoxin ST-IA/ST-P\",\"id\":\"P01559\"},{\"label\":\"Na(+)/H(+) exchange regulatory cofactor NHE-RF4\",\"id\":\"Q86UT5\"}]", "uniprot_id": "[\"P01559\",\"P25092\",\"Q86UT5\"]", "gene_symbol": "[\"GUC2C\",\"GUCY2C\",\"IKEPP\",\"NHERF4\",\"PDZD3\",\"PDZK2\",\"STAR\",\"sta1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Gain-of-function MRAS complexes activate RAF signaling", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"Leucine-rich repeat protein SHOC-2\",\"id\":\"Q9UQ13\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"Ras-related protein M-Ras\",\"id\":\"O14807\"},{\"label\":\"Serine/threonine-protein kinase A-Raf\",\"id\":\"P10398\"},{\"label\":\"Serine/threonine-protein kinase B-raf\",\"id\":\"P15056\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-beta catalytic subunit\",\"id\":\"P62140\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-gamma catalytic subunit\",\"id\":\"P36873\"}]", "uniprot_id": "[\"O14807\",\"P04049\",\"P10398\",\"P15056\",\"P31946\",\"P36873\",\"P62140\",\"Q9UQ13\"]", "gene_symbol": "[\"ARAF\",\"ARAF1\",\"BRAF\",\"BRAF1\",\"KIAA0862\",\"MRAS\",\"PKS\",\"PKS2\",\"PPP1CB\",\"PPP1CC\",\"RAF\",\"RAF1\",\"RAFB1\",\"RRAS3\",\"SHOC2\",\"YWHAB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)", "protein_name": "[{\"label\":\"Erythropoietin receptor\",\"id\":\"P19235\"},{\"label\":\"Erythropoietin\",\"id\":\"P01588\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform\",\"id\":\"O00329\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform\",\"id\":\"P48736\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 5\",\"id\":\"Q8WYR1\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"}]", "uniprot_id": "[\"O00329\",\"O60674\",\"P01588\",\"P07948\",\"P19235\",\"P27986\",\"P42336\",\"P42338\",\"P48736\",\"Q13480\",\"Q8WYR1\",\"Q9Y4H2\"]", "gene_symbol": "[\"EPO\",\"EPOR\",\"GAB1\",\"GRB1\",\"IRS2\",\"JAK2\",\"JTK8\",\"LYN\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3CD\",\"PIK3CG\",\"PIK3R1\",\"PIK3R5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NFE2L2 regulating tumorigenic genes", "protein_name": "[{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"Apoptosis regulator Bcl-2\",\"id\":\"P10415\"},{\"label\":\"Bcl-2-like protein 1\",\"id\":\"Q07817\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"},{\"label\":\"Platelet-derived growth factor subunit A\",\"id\":\"P04085\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Transcription factor MafK\",\"id\":\"O60675\"},{\"label\":\"Transcription factor Sp1\",\"id\":\"P08047\"}]", "uniprot_id": "[\"O60675\",\"P01133\",\"P04085\",\"P08047\",\"P10415\",\"P15514\",\"P46531\",\"Q07817\",\"Q09472\",\"Q16236\",\"Q92793\"]", "gene_symbol": "[\"AREG\",\"AREGB\",\"BCL2\",\"BCL2L\",\"BCL2L1\",\"BCLX\",\"CBP\",\"CREBBP\",\"EGF\",\"EP300\",\"MAFK\",\"NFE2L2\",\"NOTCH1\",\"NRF2\",\"P300\",\"PDGF1\",\"PDGFA\",\"SDGF\",\"SP1\",\"TAN1\",\"TSFP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Metabolism of folate and pterines", "protein_name": "[{\"label\":\"5-formyltetrahydrofolate cyclo-ligase\",\"id\":\"P49914\"},{\"label\":\"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial\",\"id\":\"Q9H903\"},{\"label\":\"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial\",\"id\":\"P13995\"},{\"label\":\"C-1-tetrahydrofolate synthase, cytoplasmic\",\"id\":\"P11586\"},{\"label\":\"Cytosolic 10-formyltetrahydrofolate dehydrogenase\",\"id\":\"O75891\"},{\"label\":\"Dihydrofolate reductase 2, mitochondrial\",\"id\":\"Q86XF0\"},{\"label\":\"Dihydrofolate reductase\",\"id\":\"P00374\"},{\"label\":\"Folate receptor beta\",\"id\":\"P14207\"},{\"label\":\"Methylenetetrahydrofolate reductase (NADPH)\",\"id\":\"P42898\"},{\"label\":\"Mitochondrial 10-formyltetrahydrofolate dehydrogenase\",\"id\":\"Q3SY69\"},{\"label\":\"Monofunctional C1-tetrahydrofolate synthase, mitochondrial\",\"id\":\"Q6UB35\"},{\"label\":\"Proton-coupled folate transporter\",\"id\":\"Q96NT5\"},{\"label\":\"Reduced folate transporter\",\"id\":\"P41440\"},{\"label\":\"Serine hydroxymethyltransferase, cytosolic\",\"id\":\"P34896\"},{\"label\":\"Serine hydroxymethyltransferase, mitochondrial\",\"id\":\"P34897\"},{\"label\":\"Solute carrier family 25 member 32\",\"id\":\"Q9H2D1\"}]", "uniprot_id": "[\"O75891\",\"P00374\",\"P11586\",\"P13995\",\"P14207\",\"P34896\",\"P34897\",\"P41440\",\"P42898\",\"P49914\",\"Q3SY69\",\"Q6UB35\",\"Q86XF0\",\"Q96NT5\",\"Q9H2D1\",\"Q9H903\"]", "gene_symbol": "[\"ALDH1L1\",\"ALDH1L2\",\"DHFR\",\"DHFR2\",\"DHFRL1\",\"DHFRP4\",\"FLOT1\",\"FOLR2\",\"FTHFD\",\"FTHFSDC1\",\"G21\",\"HCP1\",\"MFT\",\"MFTC\",\"MTHFC\",\"MTHFD\",\"MTHFD1\",\"MTHFD1L\",\"MTHFD2\",\"MTHFD2L\",\"MTHFR\",\"MTHFS\",\"NMDMC\",\"PCFT\",\"RFC1\",\"SHMT1\",\"SHMT2\",\"SLC19A1\",\"SLC25A32\",\"SLC46A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)", "protein_name": "[{\"label\":\"Organic cation/carnitine transporter 2\",\"id\":\"O76082\"}]", "uniprot_id": "[\"O76082\"]", "gene_symbol": "[\"OCTN2\",\"SLC22A5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Inactivation of CDC42 and RAC1", "protein_name": "[{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Rho GTPase-activating protein 39\",\"id\":\"Q9C0H5\"},{\"label\":\"Roundabout homolog 1\",\"id\":\"Q9Y6N7\"},{\"label\":\"SLIT-ROBO Rho GTPase-activating protein 1\",\"id\":\"Q7Z6B7\"},{\"label\":\"SLIT-ROBO Rho GTPase-activating protein 2\",\"id\":\"O75044\"},{\"label\":\"SLIT-ROBO Rho GTPase-activating protein 3\",\"id\":\"O43295\"},{\"label\":\"Slit homolog 2 protein\",\"id\":\"O94813\"}]", "uniprot_id": "[\"O43295\",\"O75044\",\"O94813\",\"P60953\",\"P63000\",\"Q7Z6B7\",\"Q9C0H5\",\"Q9Y6N7\"]", "gene_symbol": "[\"ARHGAP13\",\"ARHGAP14\",\"ARHGAP34\",\"ARHGAP39\",\"CDC42\",\"DUTT1\",\"FNBP2\",\"KIAA0411\",\"KIAA0456\",\"KIAA1156\",\"KIAA1304\",\"KIAA1688\",\"MEGAP\",\"RAC1\",\"ROBO1\",\"SLIL3\",\"SLIT2\",\"SRGAP1\",\"SRGAP2\",\"SRGAP2A\",\"SRGAP3\",\"TC25\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "alectinib-resistant ALK mutants", "protein_name": "[{\"label\":\"ALK tyrosine kinase receptor\",\"id\":\"Q9UM73\"}]", "uniprot_id": "[\"Q9UM73\"]", "gene_symbol": "[\"ALK\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by ERBB4", "protein_name": "[{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Gamma-aminobutyric acid receptor subunit alpha-1\",\"id\":\"P14867\"},{\"label\":\"Gamma-aminobutyric acid receptor subunit beta-1\",\"id\":\"P18505\"},{\"label\":\"Gamma-aminobutyric acid receptor subunit beta-2\",\"id\":\"P47870\"},{\"label\":\"Gamma-aminobutyric acid receptor subunit beta-3\",\"id\":\"P28472\"},{\"label\":\"Gamma-aminobutyric acid receptor subunit gamma-2\",\"id\":\"P18507\"},{\"label\":\"Gamma-aminobutyric acid receptor subunit gamma-3\",\"id\":\"Q99928\"},{\"label\":\"Gamma-aminobutyric acid receptor subunit theta\",\"id\":\"Q9UN88\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"}]", "uniprot_id": "[\"O14511\",\"O14944\",\"P00533\",\"P01133\",\"P14867\",\"P18505\",\"P18507\",\"P28472\",\"P35070\",\"P47870\",\"P56975\",\"P78352\",\"Q02297\",\"Q8WWG1\",\"Q99075\",\"Q99928\",\"Q9UN88\"]", "gene_symbol": "[\"BTC\",\"DLG4\",\"DTR\",\"DTS\",\"EGF\",\"EGFR\",\"ERBB\",\"ERBB1\",\"EREG\",\"GABRA1\",\"GABRB1\",\"GABRB2\",\"GABRB3\",\"GABRG2\",\"GABRG3\",\"GABRQ\",\"GGF\",\"HBEGF\",\"HEGFL\",\"HER1\",\"HGL\",\"HRGA\",\"NDF\",\"NRG1\",\"NRG2\",\"NRG3\",\"NRG4\",\"NTAK\",\"PSD95\",\"SMDF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective MGAT2 causes CDG-2a", "protein_name": "[{\"label\":\"Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\",\"id\":\"Q10469\"}]", "uniprot_id": "[\"Q10469\"]", "gene_symbol": "[\"MGAT2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC1A3 causes episodic ataxia 6 (EA6)", "protein_name": "[{\"label\":\"Excitatory amino acid transporter 1\",\"id\":\"P43003\"}]", "uniprot_id": "[\"P43003\"]", "gene_symbol": "[\"EAAT1\",\"GLAST\",\"GLAST1\",\"SLC1A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Class I peroxisomal membrane protein import", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family D member 1\",\"id\":\"P33897\"},{\"label\":\"ATP-binding cassette sub-family D member 2\",\"id\":\"Q9UBJ2\"},{\"label\":\"ATP-binding cassette sub-family D member 3\",\"id\":\"P28288\"},{\"label\":\"Acyl-CoA-binding domain-containing protein 5\",\"id\":\"Q5T8D3\"},{\"label\":\"Ganglioside-induced differentiation-associated protein 1\",\"id\":\"Q8TB36\"},{\"label\":\"Mitochondrial fission 1 protein\",\"id\":\"Q9Y3D6\"},{\"label\":\"Outer mitochondrial transmembrane helix translocase\",\"id\":\"Q8NBU5\"},{\"label\":\"Peroxisomal biogenesis factor 19\",\"id\":\"P40855\"},{\"label\":\"Peroxisomal biogenesis factor 3\",\"id\":\"P56589\"},{\"label\":\"Peroxisomal membrane protein 11B\",\"id\":\"O96011\"},{\"label\":\"Peroxisomal membrane protein 2\",\"id\":\"Q9NR77\"},{\"label\":\"Peroxisomal membrane protein 4\",\"id\":\"Q9Y6I8\"},{\"label\":\"Peroxisomal membrane protein PEX13\",\"id\":\"Q92968\"},{\"label\":\"Peroxisomal membrane protein PEX14\",\"id\":\"O75381\"},{\"label\":\"Peroxisomal membrane protein PEX16\",\"id\":\"Q9Y5Y5\"},{\"label\":\"Peroxisomal membrane protein PMP34\",\"id\":\"O43808\"},{\"label\":\"Peroxisome assembly protein 12\",\"id\":\"O00623\"},{\"label\":\"Peroxisome assembly protein 26\",\"id\":\"Q7Z412\"},{\"label\":\"Peroxisome biogenesis factor 2\",\"id\":\"P28328\"}]", "uniprot_id": "[\"O00623\",\"O43808\",\"O75381\",\"O96011\",\"P28288\",\"P28328\",\"P33897\",\"P40855\",\"P56589\",\"Q5T8D3\",\"Q7Z412\",\"Q8NBU5\",\"Q8TB36\",\"Q92968\",\"Q9NR77\",\"Q9UBJ2\",\"Q9Y3D6\",\"Q9Y5Y5\",\"Q9Y6I8\"]", "gene_symbol": "[\"ABCD1\",\"ABCD2\",\"ABCD3\",\"ACBD5\",\"ALD\",\"ALD1\",\"ALDL1\",\"ALDR\",\"ALDRP\",\"ATAD1\",\"FIS1\",\"GDAP1\",\"HK33\",\"KIAA1996\",\"PAF1\",\"PAF3\",\"PEX11B\",\"PEX12\",\"PEX13\",\"PEX14\",\"PEX16\",\"PEX19\",\"PEX2\",\"PEX26\",\"PEX3\",\"PMP22\",\"PMP24\",\"PMP3\",\"PMP34\",\"PMP35\",\"PMP70\",\"PXF\",\"PXMP1\",\"PXMP2\",\"PXMP3\",\"PXMP4\",\"RNF72\",\"SLC25A17\",\"TTC11\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Lactose synthesis", "protein_name": "[{\"label\":\"Alpha-lactalbumin\",\"id\":\"P00709\"},{\"label\":\"Beta-1,4-galactosyltransferase 1\",\"id\":\"P15291\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 1\",\"id\":\"P11166\"}]", "uniprot_id": "[\"P00709\",\"P11166\",\"P15291\"]", "gene_symbol": "[\"B4GALT1\",\"GGTB2\",\"GLUT1\",\"LALBA\",\"LYZL7\",\"SLC2A1\"]", "gtc_id": "[\"G58161NS\",\"G74621DY\"]" }, { "pathway_label": "Formation of the cornified envelope", "protein_name": "[{\"label\":\"Calpain small subunit 1\",\"id\":\"P04632\"},{\"label\":\"Calpain-1 catalytic subunit\",\"id\":\"P07384\"},{\"label\":\"Caspase-14\",\"id\":\"P31944\"},{\"label\":\"Chymotrypsin-like elastase family member 2A\",\"id\":\"P08217\"},{\"label\":\"Corneodesmosin\",\"id\":\"Q15517\"},{\"label\":\"Cornifin-A\",\"id\":\"P35321\"},{\"label\":\"Cornifin-B\",\"id\":\"P22528\"},{\"label\":\"Cystatin-A\",\"id\":\"P01040\"},{\"label\":\"Desmocollin-1\",\"id\":\"Q08554\"},{\"label\":\"Desmocollin-2\",\"id\":\"Q02487\"},{\"label\":\"Desmocollin-3\",\"id\":\"Q14574\"},{\"label\":\"Desmoglein-1\",\"id\":\"Q02413\"},{\"label\":\"Desmoglein-2\",\"id\":\"Q14126\"},{\"label\":\"Desmoglein-3\",\"id\":\"P32926\"},{\"label\":\"Desmoglein-4\",\"id\":\"Q86SJ6\"},{\"label\":\"Desmoplakin\",\"id\":\"P15924\"},{\"label\":\"Elafin\",\"id\":\"P19957\"},{\"label\":\"Envoplakin\",\"id\":\"Q92817\"},{\"label\":\"Filaggrin\",\"id\":\"P20930\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Involucrin\",\"id\":\"P07476\"},{\"label\":\"Junction plakoglobin\",\"id\":\"P14923\"},{\"label\":\"Kallikrein-12\",\"id\":\"Q9UKR0\"},{\"label\":\"Kallikrein-13\",\"id\":\"Q9UKR3\"},{\"label\":\"Kallikrein-14\",\"id\":\"Q9P0G3\"},{\"label\":\"Kallikrein-5\",\"id\":\"Q9Y337\"},{\"label\":\"Kallikrein-8\",\"id\":\"O60259\"},{\"label\":\"Kazrin\",\"id\":\"Q674X7\"},{\"label\":\"Late cornified envelope protein 1A\",\"id\":\"Q5T7P2\"},{\"label\":\"Late cornified envelope protein 1B\",\"id\":\"Q5T7P3\"},{\"label\":\"Late cornified envelope protein 1C\",\"id\":\"Q5T751\"},{\"label\":\"Late cornified envelope protein 1D\",\"id\":\"Q5T752\"},{\"label\":\"Late cornified envelope protein 1E\",\"id\":\"Q5T753\"},{\"label\":\"Late cornified envelope protein 1F\",\"id\":\"Q5T754\"},{\"label\":\"Late cornified envelope protein 2A\",\"id\":\"Q5TA79\"},{\"label\":\"Late cornified envelope protein 2B\",\"id\":\"O14633\"},{\"label\":\"Late cornified envelope protein 2C\",\"id\":\"Q5TA81\"},{\"label\":\"Late cornified envelope protein 2D\",\"id\":\"Q5TA82\"},{\"label\":\"Late cornified envelope protein 3A\",\"id\":\"Q5TA76\"},{\"label\":\"Late cornified envelope protein 3B\",\"id\":\"Q5TA77\"},{\"label\":\"Late cornified envelope protein 3C\",\"id\":\"Q5T5A8\"},{\"label\":\"Late cornified envelope protein 3D\",\"id\":\"Q9BYE3\"},{\"label\":\"Late cornified envelope protein 3E\",\"id\":\"Q5T5B0\"},{\"label\":\"Late cornified envelope protein 4A\",\"id\":\"Q5TA78\"},{\"label\":\"Late cornified envelope protein 5A\",\"id\":\"Q5TCM9\"},{\"label\":\"Late cornified envelope protein 6A\",\"id\":\"A0A183\"},{\"label\":\"Late cornified envelope-like proline-rich protein 1\",\"id\":\"Q5T871\"},{\"label\":\"Lipase member J\",\"id\":\"Q5W064\"},{\"label\":\"Lipase member K\",\"id\":\"Q5VXJ0\"},{\"label\":\"Lipase member M\",\"id\":\"Q5VYY2\"},{\"label\":\"Lipase member 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proline-rich protein 2D\",\"id\":\"P22532\"},{\"label\":\"Small proline-rich protein 2E\",\"id\":\"P22531\"},{\"label\":\"Small proline-rich protein 2F\",\"id\":\"Q96RM1\"},{\"label\":\"Small proline-rich protein 2G\",\"id\":\"Q9BYE4\"},{\"label\":\"Small proline-rich protein 3\",\"id\":\"Q9UBC9\"},{\"label\":\"Suppressor of tumorigenicity 14 protein\",\"id\":\"Q9Y5Y6\"},{\"label\":\"Trichohyalin\",\"id\":\"Q07283\"},{\"label\":\"p53 apoptosis effector related to PMP-22\",\"id\":\"Q96FX8\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Major pathway of rRNA processing in the nucleolus and cytosol", "protein_name": "[{\"label\":\"18S rRNA (guanine-N(7))-methyltransferase\",\"id\":\"O43709\"},{\"label\":\"3'-5' exoribonuclease 1\",\"id\":\"Q8IV48\"},{\"label\":\"5'-3' exoribonuclease 2\",\"id\":\"Q9H0D6\"},{\"label\":\"60S ribosome subunit biogenesis protein NIP7 homolog\",\"id\":\"Q9Y221\"},{\"label\":\"Bystin\",\"id\":\"Q13895\"},{\"label\":\"Casein kinase I isoform delta\",\"id\":\"P48730\"},{\"label\":\"Casein kinase I isoform epsilon\",\"id\":\"P49674\"},{\"label\":\"DDB1- and CUL4-associated factor 13\",\"id\":\"Q9NV06\"},{\"label\":\"Exosome RNA helicase MTR4\",\"id\":\"P42285\"},{\"label\":\"Exosome complex component 10\",\"id\":\"Q01780\"},{\"label\":\"Exosome complex component CSL4\",\"id\":\"Q9Y3B2\"},{\"label\":\"Exosome complex component MTR3\",\"id\":\"Q5RKV6\"},{\"label\":\"Exosome complex component RRP40\",\"id\":\"Q9NQT5\"},{\"label\":\"Exosome complex component RRP41\",\"id\":\"Q9NPD3\"},{\"label\":\"Exosome complex component RRP42\",\"id\":\"Q15024\"},{\"label\":\"Exosome complex component RRP43\",\"id\":\"Q96B26\"},{\"label\":\"Exosome complex component RRP45\",\"id\":\"Q06265\"},{\"label\":\"Exosome complex component RRP46\",\"id\":\"Q9NQT4\"},{\"label\":\"Exosome complex component RRP4\",\"id\":\"Q13868\"},{\"label\":\"Exosome complex exonuclease RRP44\",\"id\":\"Q9Y2L1\"},{\"label\":\"Guanine nucleotide-binding protein-like 3\",\"id\":\"Q9BVP2\"},{\"label\":\"HEAT repeat-containing protein 1\",\"id\":\"Q9H583\"},{\"label\":\"Interferon-stimulated 20 kDa exonuclease-like 2\",\"id\":\"Q9H9L3\"},{\"label\":\"KRR1 small subunit processome component homolog\",\"id\":\"Q13601\"},{\"label\":\"Large ribosomal subunit protein P1\",\"id\":\"P05386\"},{\"label\":\"Large ribosomal subunit protein P2\",\"id\":\"P05387\"},{\"label\":\"Large ribosomal subunit protein eL13\",\"id\":\"P26373\"},{\"label\":\"Large ribosomal subunit protein eL14\",\"id\":\"P50914\"},{\"label\":\"Large ribosomal subunit protein eL15\",\"id\":\"P61313\"},{\"label\":\"Large ribosomal subunit protein eL18\",\"id\":\"Q07020\"},{\"label\":\"Large ribosomal subunit protein eL19\",\"id\":\"P84098\"},{\"label\":\"Large ribosomal subunit protein eL20\",\"id\":\"Q02543\"},{\"label\":\"Large ribosomal subunit protein eL21\",\"id\":\"P46778\"},{\"label\":\"Large ribosomal subunit protein eL22\",\"id\":\"P35268\"},{\"label\":\"Large ribosomal subunit protein eL24\",\"id\":\"P83731\"},{\"label\":\"Large ribosomal subunit protein eL27\",\"id\":\"P61353\"},{\"label\":\"Large ribosomal subunit protein eL28\",\"id\":\"P46779\"},{\"label\":\"Large ribosomal subunit protein eL29\",\"id\":\"P47914\"},{\"label\":\"Large ribosomal subunit protein eL30\",\"id\":\"P62888\"},{\"label\":\"Large ribosomal subunit protein eL31\",\"id\":\"P62899\"},{\"label\":\"Large ribosomal subunit protein eL32\",\"id\":\"P62910\"},{\"label\":\"Large ribosomal subunit protein eL33\",\"id\":\"P18077\"},{\"label\":\"Large ribosomal subunit protein eL34\",\"id\":\"P49207\"},{\"label\":\"Large ribosomal subunit protein eL36\",\"id\":\"Q9Y3U8\"},{\"label\":\"Large ribosomal subunit protein eL37\",\"id\":\"P61927\"},{\"label\":\"Large ribosomal subunit protein eL38\",\"id\":\"P63173\"},{\"label\":\"Large ribosomal subunit protein eL39\",\"id\":\"P62891\"},{\"label\":\"Large ribosomal subunit protein eL42\",\"id\":\"P83881\"},{\"label\":\"Large ribosomal subunit protein eL43\",\"id\":\"P61513\"},{\"label\":\"Large ribosomal subunit protein eL6\",\"id\":\"Q02878\"},{\"label\":\"Large ribosomal subunit protein eL8\",\"id\":\"P62424\"},{\"label\":\"Large ribosomal subunit protein uL10\",\"id\":\"P05388\"},{\"label\":\"Large ribosomal subunit protein uL11\",\"id\":\"P30050\"},{\"label\":\"Large ribosomal subunit protein uL13\",\"id\":\"P40429\"},{\"label\":\"Large ribosomal subunit protein uL14\",\"id\":\"P62829\"},{\"label\":\"Large ribosomal subunit protein uL15\",\"id\":\"P46776\"},{\"label\":\"Large ribosomal subunit protein uL16\",\"id\":\"P27635\"},{\"label\":\"Large ribosomal subunit protein uL18\",\"id\":\"P46777\"},{\"label\":\"Large ribosomal subunit protein uL1\",\"id\":\"P62906\"},{\"label\":\"Large ribosomal subunit protein uL22\",\"id\":\"P18621\"},{\"label\":\"Large ribosomal subunit protein uL23\",\"id\":\"P62750\"},{\"label\":\"Large ribosomal subunit protein uL24\",\"id\":\"P61254\"},{\"label\":\"Large ribosomal subunit protein uL29\",\"id\":\"P42766\"},{\"label\":\"Large ribosomal subunit protein uL2\",\"id\":\"P62917\"},{\"label\":\"Large ribosomal subunit protein uL30\",\"id\":\"P18124\"},{\"label\":\"Large ribosomal subunit protein uL3\",\"id\":\"P39023\"},{\"label\":\"Large ribosomal subunit protein uL4\",\"id\":\"P36578\"},{\"label\":\"Large ribosomal subunit protein uL5\",\"id\":\"P62913\"},{\"label\":\"Large ribosomal subunit protein uL6\",\"id\":\"P32969\"},{\"label\":\"M-phase phosphoprotein 6\",\"id\":\"Q99547\"},{\"label\":\"NHP2-like protein 1\",\"id\":\"P55769\"},{\"label\":\"Nuclear nucleic acid-binding protein C1D\",\"id\":\"Q13901\"},{\"label\":\"Nucleolar RNA helicase 2\",\"id\":\"Q9NR30\"},{\"label\":\"Nucleolar complex protein 4 homolog\",\"id\":\"Q9BVI4\"},{\"label\":\"Nucleolar protein 11\",\"id\":\"Q9H8H0\"},{\"label\":\"Nucleolar protein 12\",\"id\":\"Q9UGY1\"},{\"label\":\"Nucleolar protein 14\",\"id\":\"P78316\"},{\"label\":\"Nucleolar protein 56\",\"id\":\"O00567\"},{\"label\":\"Nucleolar protein 58\",\"id\":\"Q9Y2X3\"},{\"label\":\"Nucleolar protein 6\",\"id\":\"Q9H6R4\"},{\"label\":\"Nucleolin\",\"id\":\"P19338\"},{\"label\":\"Periodic tryptophan protein 2 homolog\",\"id\":\"Q15269\"},{\"label\":\"Pescadillo homolog\",\"id\":\"O00541\"},{\"label\":\"Polynucleotide 5'-hydroxyl-kinase NOL9\",\"id\":\"Q5SY16\"},{\"label\":\"Pre-rRNA-processing protein TSR1 homolog\",\"id\":\"Q2NL82\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX47\",\"id\":\"Q9H0S4\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX49\",\"id\":\"Q9Y6V7\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX52\",\"id\":\"Q9Y2R4\"},{\"label\":\"Probable ATP-dependent RNA helicase DHX37\",\"id\":\"Q8IY37\"},{\"label\":\"Probable U3 small nucleolar RNA-associated protein 11\",\"id\":\"Q9Y3A2\"},{\"label\":\"Probable rRNA-processing protein EBP2\",\"id\":\"Q99848\"},{\"label\":\"Proline-, glutamic acid- and leucine-rich protein 1\",\"id\":\"Q8IZL8\"},{\"label\":\"Protein LTV1 homolog\",\"id\":\"Q96GA3\"},{\"label\":\"Protein RRP5 homolog\",\"id\":\"Q14690\"},{\"label\":\"RNA 3'-terminal phosphate cyclase-like protein\",\"id\":\"Q9Y2P8\"},{\"label\":\"RNA-binding protein 28\",\"id\":\"Q9NW13\"},{\"label\":\"RNA-binding protein NOB1\",\"id\":\"Q9ULX3\"},{\"label\":\"RNA-binding protein PNO1\",\"id\":\"Q9NRX1\"},{\"label\":\"Ribonuclease P protein subunit p14\",\"id\":\"O95059\"},{\"label\":\"Ribonuclease P protein subunit p21\",\"id\":\"Q9H633\"},{\"label\":\"Ribonuclease P protein subunit p25\",\"id\":\"Q9BUL9\"},{\"label\":\"Ribonuclease P protein subunit p30\",\"id\":\"P78346\"},{\"label\":\"Ribonuclease P protein subunit p38\",\"id\":\"P78345\"},{\"label\":\"Ribonuclease P protein subunit p40\",\"id\":\"O75818\"},{\"label\":\"Ribosomal RNA processing protein 1 homolog A\",\"id\":\"P56182\"},{\"label\":\"Ribosomal RNA processing protein 36 homolog\",\"id\":\"Q96EU6\"},{\"label\":\"Ribosomal RNA small subunit methyltransferase NEP1\",\"id\":\"Q92979\"},{\"label\":\"Ribosomal RNA-processing protein 7 homolog A\",\"id\":\"Q9Y3A4\"},{\"label\":\"Ribosomal biogenesis protein LAS1L\",\"id\":\"Q9Y4W2\"},{\"label\":\"Ribosomal protein eL22-like\",\"id\":\"Q6P5R6\"},{\"label\":\"Ribosomal protein eL39-like 2\",\"id\":\"Q96EH5\"},{\"label\":\"Ribosomal protein eL42-like\",\"id\":\"Q969Q0\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Ribosomal protein uL16-like\",\"id\":\"Q96L21\"},{\"label\":\"Ribosomal protein uL24-like\",\"id\":\"Q9UNX3\"},{\"label\":\"Ribosomal protein uL3-like\",\"id\":\"Q92901\"},{\"label\":\"Ribosome biogenesis protein BMS1 homolog\",\"id\":\"Q14692\"},{\"label\":\"Ribosome biogenesis protein BOP1\",\"id\":\"Q14137\"},{\"label\":\"Ribosome biogenesis protein WDR12\",\"id\":\"Q9GZL7\"},{\"label\":\"Sentrin-specific protease 3\",\"id\":\"Q9H4L4\"},{\"label\":\"Serine/threonine-protein kinase RIO1\",\"id\":\"Q9BRS2\"},{\"label\":\"Serine/threonine-protein kinase RIO2\",\"id\":\"Q9BVS4\"},{\"label\":\"Serine/threonine-protein kinase RIO3\",\"id\":\"O14730\"},{\"label\":\"Small ribosomal subunit protein eS10\",\"id\":\"P46783\"},{\"label\":\"Small ribosomal subunit protein eS12\",\"id\":\"P25398\"},{\"label\":\"Small ribosomal subunit protein eS17\",\"id\":\"P08708\"},{\"label\":\"Small ribosomal subunit protein eS19\",\"id\":\"P39019\"},{\"label\":\"Small ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS32\",\"id\":\"P62945\"},{\"label\":\"Small ribosomal subunit protein eS4, X isoform\",\"id\":\"P62701\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 1\",\"id\":\"P22090\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 2\",\"id\":\"Q8TD47\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein eS7\",\"id\":\"P62081\"},{\"label\":\"Small ribosomal subunit protein eS8\",\"id\":\"P62241\"},{\"label\":\"Small ribosomal subunit protein uS10\",\"id\":\"P60866\"},{\"label\":\"Small ribosomal subunit protein uS11\",\"id\":\"P62263\"},{\"label\":\"Small ribosomal subunit protein uS12\",\"id\":\"P62266\"},{\"label\":\"Small ribosomal subunit protein uS13\",\"id\":\"P62269\"},{\"label\":\"Small ribosomal subunit protein uS14\",\"id\":\"P62273\"},{\"label\":\"Small ribosomal subunit protein uS15\",\"id\":\"P62277\"},{\"label\":\"Small ribosomal subunit protein uS17\",\"id\":\"P62280\"},{\"label\":\"Small ribosomal subunit protein uS19\",\"id\":\"P62841\"},{\"label\":\"Small ribosomal subunit protein uS2\",\"id\":\"P08865\"},{\"label\":\"Small ribosomal subunit protein uS3\",\"id\":\"P23396\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small ribosomal subunit protein uS7\",\"id\":\"P46782\"},{\"label\":\"Small ribosomal subunit protein uS8\",\"id\":\"P62244\"},{\"label\":\"Small ribosomal subunit protein uS9\",\"id\":\"P62249\"},{\"label\":\"Small subunit processome component 20 homolog\",\"id\":\"O75691\"},{\"label\":\"Something about silencing protein 10\",\"id\":\"Q9NQZ2\"},{\"label\":\"Testis-expressed protein 10\",\"id\":\"Q9NXF1\"},{\"label\":\"Transducin beta-like protein 3\",\"id\":\"Q12788\"},{\"label\":\"U3 small nucleolar RNA-associated protein 14 homolog A\",\"id\":\"Q9BVJ6\"},{\"label\":\"U3 small nucleolar RNA-associated protein 14 homolog C\",\"id\":\"Q5TAP6\"},{\"label\":\"U3 small nucleolar RNA-associated protein 15 homolog\",\"id\":\"Q8TED0\"},{\"label\":\"U3 small nucleolar RNA-associated protein 18 homolog\",\"id\":\"Q9Y5J1\"},{\"label\":\"U3 small nucleolar RNA-associated protein 25 homolog\",\"id\":\"Q68CQ4\"},{\"label\":\"U3 small nucleolar RNA-associated protein 4 homolog\",\"id\":\"Q969X6\"},{\"label\":\"U3 small nucleolar RNA-associated protein 6 homolog\",\"id\":\"Q9NYH9\"},{\"label\":\"U3 small nucleolar RNA-interacting protein 2\",\"id\":\"O43818\"},{\"label\":\"U3 small nucleolar ribonucleoprotein protein IMP3\",\"id\":\"Q9NV31\"},{\"label\":\"U3 small nucleolar ribonucleoprotein protein IMP4\",\"id\":\"Q96G21\"},{\"label\":\"U3 small nucleolar ribonucleoprotein protein MPP10\",\"id\":\"O00566\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"WD repeat-containing protein 18\",\"id\":\"Q9BV38\"},{\"label\":\"WD repeat-containing protein 36\",\"id\":\"Q8NI36\"},{\"label\":\"WD repeat-containing protein 3\",\"id\":\"Q9UNX4\"},{\"label\":\"WD repeat-containing protein 43\",\"id\":\"Q15061\"},{\"label\":\"WD repeat-containing protein 46\",\"id\":\"O15213\"},{\"label\":\"WD repeat-containing protein 75\",\"id\":\"Q8IWA0\"},{\"label\":\"pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3\",\"id\":\"Q8IY81\"},{\"label\":\"rRNA 2'-O-methyltransferase fibrillarin\",\"id\":\"P22087\"},{\"label\":\"rRNA-processing protein FCF1 homolog\",\"id\":\"Q9Y324\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Glycosaminoglycan metabolism", "protein_name": "[{\"label\":\"UDP-glucuronic acid decarboxylase 1\",\"id\":\"Q8NBZ7\"}]", "uniprot_id": "[\"Q8NBZ7\"]", "gene_symbol": "[\"UXS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective CUBN causes MGA1", "protein_name": "[{\"label\":\"Cobalamin binding intrinsic factor\",\"id\":\"P27352\"},{\"label\":\"Cubilin\",\"id\":\"O60494\"},{\"label\":\"Protein amnionless\",\"id\":\"Q9BXJ7\"}]", "uniprot_id": "[\"O60494\",\"P27352\",\"Q9BXJ7\"]", "gene_symbol": "[\"AMN\",\"CBLIF\",\"CUBN\",\"GIF\",\"IFCR\",\"IFMH\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Deactivation of the beta-catenin transactivating complex", "protein_name": "[{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"Adenomatous polyposis coli protein\",\"id\":\"P25054\"},{\"label\":\"B-cell CLL/lymphoma 9 protein\",\"id\":\"O00512\"},{\"label\":\"B-cell CLL/lymphoma 9-like protein\",\"id\":\"Q86UU0\"},{\"label\":\"Beta-catenin-interacting protein 1\",\"id\":\"Q9NSA3\"},{\"label\":\"C-terminal-binding protein 1\",\"id\":\"Q13363\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 8\",\"id\":\"Q9HCK8\"},{\"label\":\"E3 ubiquitin-protein ligase XIAP\",\"id\":\"P98170\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone-lysine N-methyltransferase 2D\",\"id\":\"O14686\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Menin\",\"id\":\"O00255\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein chibby homolog 1\",\"id\":\"Q9Y3M2\"},{\"label\":\"Pygopus homolog 1\",\"id\":\"Q9Y3Y4\"},{\"label\":\"Pygopus homolog 2\",\"id\":\"Q9BRQ0\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"Retinoblastoma-binding protein 5\",\"id\":\"Q15291\"},{\"label\":\"Set1/Ash2 histone methyltransferase complex subunit ASH2\",\"id\":\"Q9UBL3\"},{\"label\":\"Sex-determining region Y protein\",\"id\":\"Q05066\"},{\"label\":\"Transcription factor 7-like 1\",\"id\":\"Q9HCS4\"},{\"label\":\"Transcription factor 7-like 2\",\"id\":\"Q9NQB0\"},{\"label\":\"Transcription factor 7\",\"id\":\"P36402\"},{\"label\":\"Transcription factor SOX-13\",\"id\":\"Q9UN79\"},{\"label\":\"Transcription factor SOX-17\",\"id\":\"Q9H6I2\"},{\"label\":\"Transcription factor SOX-2\",\"id\":\"P48431\"},{\"label\":\"Transcription factor SOX-3\",\"id\":\"P41225\"},{\"label\":\"Transcription factor SOX-4\",\"id\":\"Q06945\"},{\"label\":\"Transcription factor SOX-6\",\"id\":\"P35712\"},{\"label\":\"Transcription factor SOX-7\",\"id\":\"Q9BT81\"},{\"label\":\"Transcription factor SOX-9\",\"id\":\"P48436\"},{\"label\":\"Transducin-like enhancer protein 1\",\"id\":\"Q04724\"},{\"label\":\"Transducin-like enhancer protein 2\",\"id\":\"Q04725\"},{\"label\":\"Transducin-like enhancer protein 3\",\"id\":\"Q04726\"},{\"label\":\"Transducin-like enhancer protein 4\",\"id\":\"Q04727\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00255\",\"O00512\",\"O14686\",\"O14980\",\"P0CG47\",\"P0CG48\",\"P25054\",\"P31749\",\"P31751\",\"P35222\",\"P35712\",\"P36402\",\"P41225\",\"P48431\",\"P48436\",\"P62979\",\"P62987\",\"P63104\",\"P98170\",\"Q04724\",\"Q04725\",\"Q04726\",\"Q04727\",\"Q05066\",\"Q06945\",\"Q13363\",\"Q13547\",\"Q15291\",\"Q86UU0\",\"Q9BRQ0\",\"Q9BT81\",\"Q9H6I2\",\"Q9HCK8\",\"Q9HCS4\",\"Q9NQB0\",\"Q9NSA3\",\"Q9UBL3\",\"Q9UJU2\",\"Q9UN79\",\"Q9Y297\",\"Q9Y3M2\",\"Q9Y3Y4\"]", "gene_symbol": 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11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Anaphase-promoting complex subunit 10\",\"id\":\"Q9UM13\"},{\"label\":\"Anaphase-promoting complex subunit 11\",\"id\":\"Q9NYG5\"},{\"label\":\"Anaphase-promoting complex subunit 15\",\"id\":\"P60006\"},{\"label\":\"Anaphase-promoting complex subunit 16\",\"id\":\"Q96DE5\"},{\"label\":\"Anaphase-promoting complex subunit 1\",\"id\":\"Q9H1A4\"},{\"label\":\"Anaphase-promoting complex subunit 2\",\"id\":\"Q9UJX6\"},{\"label\":\"Anaphase-promoting complex subunit 4\",\"id\":\"Q9UJX5\"},{\"label\":\"Anaphase-promoting complex subunit 5\",\"id\":\"Q9UJX4\"},{\"label\":\"Anaphase-promoting complex subunit 7\",\"id\":\"Q9UJX3\"},{\"label\":\"Anaphase-promoting complex subunit CDC26\",\"id\":\"Q8NHZ8\"},{\"label\":\"Aurora kinase B\",\"id\":\"Q96GD4\"},{\"label\":\"B9 domain-containing protein 2\",\"id\":\"Q9BPU9\"},{\"label\":\"Baculoviral IAP repeat-containing protein 5\",\"id\":\"O15392\"},{\"label\":\"Borealin\",\"id\":\"Q53HL2\"},{\"label\":\"CAP-Gly domain-containing linker protein 1\",\"id\":\"P30622\"},{\"label\":\"CLIP-associating protein 1\",\"id\":\"Q7Z460\"},{\"label\":\"CLIP-associating protein 2\",\"id\":\"O75122\"},{\"label\":\"Cell division cycle protein 16 homolog\",\"id\":\"Q13042\"},{\"label\":\"Cell division cycle protein 20 homolog\",\"id\":\"Q12834\"},{\"label\":\"Cell division cycle protein 23 homolog\",\"id\":\"Q9UJX2\"},{\"label\":\"Cell division cycle protein 27 homolog\",\"id\":\"P30260\"},{\"label\":\"Centromere protein C\",\"id\":\"Q03188\"},{\"label\":\"Centromere protein F\",\"id\":\"P49454\"},{\"label\":\"Centromere protein H\",\"id\":\"Q9H3R5\"},{\"label\":\"Centromere protein I\",\"id\":\"Q92674\"},{\"label\":\"Centromere protein K\",\"id\":\"Q9BS16\"},{\"label\":\"Centromere protein L\",\"id\":\"Q8N0S6\"},{\"label\":\"Centromere protein M\",\"id\":\"Q9NSP4\"},{\"label\":\"Centromere protein N\",\"id\":\"Q96H22\"},{\"label\":\"Centromere protein O\",\"id\":\"Q9BU64\"},{\"label\":\"Centromere protein P\",\"id\":\"Q6IPU0\"},{\"label\":\"Centromere protein Q\",\"id\":\"Q7L2Z9\"},{\"label\":\"Centromere protein R\",\"id\":\"Q13352\"},{\"label\":\"Centromere protein S\",\"id\":\"Q8N2Z9\"},{\"label\":\"Centromere protein T\",\"id\":\"Q96BT3\"},{\"label\":\"Centromere protein U\",\"id\":\"Q71F23\"},{\"label\":\"Centromere-associated protein E\",\"id\":\"Q02224\"},{\"label\":\"Centromere/kinetochore protein zw10 homolog\",\"id\":\"O43264\"},{\"label\":\"Cohesin subunit SA-1\",\"id\":\"Q8WVM7\"},{\"label\":\"Cohesin subunit SA-2\",\"id\":\"Q8N3U4\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 1\",\"id\":\"O14576\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 1\",\"id\":\"Q9Y6G9\"},{\"label\":\"Cytoplasmic dynein 1 light intermediate chain 2\",\"id\":\"O43237\"},{\"label\":\"Cytoskeleton-associated protein 5\",\"id\":\"Q14008\"},{\"label\":\"DNA excision repair protein ERCC-6-like\",\"id\":\"Q2NKX8\"},{\"label\":\"Double-strand-break repair protein rad21 homolog\",\"id\":\"O60216\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"Dynein light chain 2, cytoplasmic\",\"id\":\"Q96FJ2\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Exportin-1\",\"id\":\"O14980\"},{\"label\":\"Histone H3-like centromeric protein A\",\"id\":\"P49450\"},{\"label\":\"Inner centromere protein\",\"id\":\"Q9NQS7\"},{\"label\":\"Kinesin-like protein KIF18A\",\"id\":\"Q8NI77\"},{\"label\":\"Kinesin-like protein KIF2A\",\"id\":\"O00139\"},{\"label\":\"Kinesin-like protein KIF2B\",\"id\":\"Q8N4N8\"},{\"label\":\"Kinesin-like protein KIF2C\",\"id\":\"Q99661\"},{\"label\":\"Kinetochore protein NDC80 homolog\",\"id\":\"O14777\"},{\"label\":\"Kinetochore protein Nuf2\",\"id\":\"Q9BZD4\"},{\"label\":\"Kinetochore protein Spc24\",\"id\":\"Q8NBT2\"},{\"label\":\"Kinetochore protein Spc25\",\"id\":\"Q9HBM1\"},{\"label\":\"Kinetochore scaffold 1\",\"id\":\"Q8NG31\"},{\"label\":\"Kinetochore-associated protein 1\",\"id\":\"P50748\"},{\"label\":\"Kinetochore-associated protein DSN1 homolog\",\"id\":\"Q9H410\"},{\"label\":\"Kinetochore-associated protein NSL1 homolog\",\"id\":\"Q96IY1\"},{\"label\":\"Microtubule-associated protein RP/EB family member 1\",\"id\":\"Q15691\"},{\"label\":\"Mitotic checkpoint protein BUB3\",\"id\":\"O43684\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta\",\"id\":\"O60566\"},{\"label\":\"Mitotic checkpoint serine/threonine-protein kinase BUB1\",\"id\":\"O43683\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD1\",\"id\":\"Q9Y6D9\"},{\"label\":\"Mitotic spindle assembly checkpoint protein MAD2A\",\"id\":\"Q13257\"},{\"label\":\"Nuclear distribution protein nudE homolog 1\",\"id\":\"Q9NXR1\"},{\"label\":\"Nuclear distribution protein nudE-like 1\",\"id\":\"Q9GZM8\"},{\"label\":\"Nuclear migration protein nudC\",\"id\":\"Q9Y266\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit beta\",\"id\":\"P43034\"},{\"label\":\"Polyamine-modulated factor 1\",\"id\":\"Q6P1K2\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)", "protein_name": "[{\"label\":\"Sodium/iodide cotransporter\",\"id\":\"Q92911\"}]", "uniprot_id": "[\"Q92911\"]", "gene_symbol": "[\"NIS\",\"SLC5A5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Events associated with phagocytolytic activity of PMN cells", "protein_name": "[{\"label\":\"Lactoperoxidase\",\"id\":\"P22079\"},{\"label\":\"Myeloperoxidase\",\"id\":\"P05164\"}]", "uniprot_id": "[\"P05164\",\"P22079\"]", "gene_symbol": "[\"LPO\",\"MPO\",\"SAPX\"]", "gtc_id": "[\"G49108TO\"]" }, { "pathway_label": "MPS IV - Morquio syndrome A", "protein_name": "[{\"label\":\"N-acetylgalactosamine-6-sulfatase\",\"id\":\"P34059\"}]", "uniprot_id": "[\"P34059\"]", "gene_symbol": "[\"GALNS\"]", "gtc_id": "[\"G85384LV\"]" }, { "pathway_label": "Synthesis of Hepoxilins (HX) and Trioxilins (TrX)", "protein_name": "[{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX12\",\"id\":\"P18054\"}]", "uniprot_id": "[\"P18054\"]", "gene_symbol": "[\"12LO\",\"ALOX12\",\"LOG12\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Pol II CTD phosphorylation and interaction with CE", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit 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2\",\"id\":\"Q9BYF1\"},{\"label\":\"Anoctamin-10\",\"id\":\"Q9NW15\"},{\"label\":\"Anoctamin-1\",\"id\":\"Q5XXA6\"},{\"label\":\"Anoctamin-2\",\"id\":\"Q9NQ90\"},{\"label\":\"Anoctamin-3\",\"id\":\"Q9BYT9\"},{\"label\":\"Anoctamin-4\",\"id\":\"Q32M45\"},{\"label\":\"Anoctamin-5\",\"id\":\"Q75V66\"},{\"label\":\"Anoctamin-6\",\"id\":\"Q4KMQ2\"},{\"label\":\"Anoctamin-7\",\"id\":\"Q6IWH7\"},{\"label\":\"Anoctamin-8\",\"id\":\"Q9HCE9\"},{\"label\":\"Anoctamin-9\",\"id\":\"A1A5B4\"},{\"label\":\"Envelope small membrane protein\",\"id\":\"P0DTC4\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Membrane protein\",\"id\":\"P0DTC5\"},{\"label\":\"Nucleoprotein\",\"id\":\"P0DTC9\"},{\"label\":\"ORF3a protein\",\"id\":\"P0DTC3\"},{\"label\":\"ORF7a protein\",\"id\":\"P0DTC7\"},{\"label\":\"Spike glycoprotein\",\"id\":\"P0DTC2\"},{\"label\":\"Transmembrane protease serine 2\",\"id\":\"O15393\"}]", "uniprot_id": 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1-dehydrogenase\",\"id\":\"P11413\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"},{\"label\":\"Transaldolase\",\"id\":\"P37837\"},{\"label\":\"Transcription factor MafG\",\"id\":\"O15525\"},{\"label\":\"Transketolase\",\"id\":\"P29401\"}]", "uniprot_id": "[\"O15525\",\"P11413\",\"P29401\",\"P37837\",\"P52209\",\"Q09472\",\"Q16236\",\"Q92793\"]", "gene_symbol": "[\"CBP\",\"CREBBP\",\"EP300\",\"G6PD\",\"MAFG\",\"NFE2L2\",\"NRF2\",\"P300\",\"PGD\",\"PGDH\",\"TAL\",\"TALDO\",\"TALDO1\",\"TALDOR\",\"TKT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Recognition of DNA damage by PCNA-containing replication complex", "protein_name": "[{\"label\":\"Cullin-4A\",\"id\":\"Q13619\"},{\"label\":\"Cullin-4B\",\"id\":\"Q13620\"},{\"label\":\"DNA damage-binding protein 1\",\"id\":\"Q16531\"},{\"label\":\"DNA polymerase delta catalytic subunit\",\"id\":\"P28340\"},{\"label\":\"DNA polymerase delta subunit 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3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 1\",\"id\":\"O94782\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 B\",\"id\":\"P63146\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"WD repeat-containing protein 48\",\"id\":\"Q8TAF3\"}]", "uniprot_id": 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Quality Control Compartment (ERQC)", "protein_name": "[{\"label\":\"Derlin-2\",\"id\":\"Q9GZP9\"},{\"label\":\"E3 ubiquitin-protein ligase AMFR\",\"id\":\"Q9UKV5\"},{\"label\":\"E3 ubiquitin-protein ligase MARCHF6\",\"id\":\"O60337\"},{\"label\":\"E3 ubiquitin-protein ligase RNF103\",\"id\":\"O00237\"},{\"label\":\"E3 ubiquitin-protein ligase RNF139\",\"id\":\"Q8WU17\"},{\"label\":\"E3 ubiquitin-protein ligase RNF185\",\"id\":\"Q96GF1\"},{\"label\":\"E3 ubiquitin-protein ligase RNF5\",\"id\":\"Q99942\"},{\"label\":\"E3 ubiquitin-protein ligase TRIM13\",\"id\":\"O60858\"},{\"label\":\"E3 ubiquitin-protein ligase synoviolin\",\"id\":\"Q86TM6\"},{\"label\":\"ER degradation-enhancing alpha-mannosidase-like protein 1\",\"id\":\"Q92611\"},{\"label\":\"ER degradation-enhancing alpha-mannosidase-like protein 2\",\"id\":\"Q9BV94\"},{\"label\":\"ER degradation-enhancing alpha-mannosidase-like protein 3\",\"id\":\"Q9BZQ6\"},{\"label\":\"Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase\",\"id\":\"Q9UKM7\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein OS-9\",\"id\":\"Q13438\"},{\"label\":\"Protein sel-1 homolog 1\",\"id\":\"Q9UBV2\"},{\"label\":\"UDP-glucose\",\"id\":\"glycoprotein glucosyltransferase 1:Q9NYU2\"},{\"label\":\"UDP-glucose\",\"id\":\"glycoprotein glucosyltransferase 2:Q9NYU1\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00237\",\"O60337\",\"O60858\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q13438\",\"Q86TM6\",\"Q8WU17\",\"Q92611\",\"Q96GF1\",\"Q99942\",\"Q9BV94\",\"Q9BZQ6\",\"Q9GZP9\",\"Q9NYU1\",\"Q9NYU2\",\"Q9UBV2\",\"Q9UKM7\",\"Q9UKV5\"]", "gene_symbol": "[\"AMFR\",\"C1orf22\",\"C20orf31\",\"C20orf49\",\"DER2\",\"DERL2\",\"EDEM\",\"EDEM1\",\"EDEM2\",\"EDEM3\",\"FLANA\",\"G16\",\"GT\",\"HRD1\",\"KIAA0212\",\"KIAA0597\",\"KIAA1810\",\"LEU5\",\"MAN1B1\",\"MARCH6\",\"MARCHF6\",\"NG2\",\"OS9\",\"RFP2\",\"RMA1\",\"RNF103\",\"RNF139\",\"RNF176\",\"RNF185\",\"RNF45\",\"RNF5\",\"RNF77\",\"RPS27A\",\"SEL1L\",\"SYVN1\",\"TEB4\",\"TRC8\",\"TRIM13\",\"TSA305\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"UGCGL1\",\"UGCGL2\",\"UGGT\",\"UGGT1\",\"UGGT2\",\"UGT1\",\"UGT2\",\"UGTR\",\"ZFP103\"]", "gtc_id": "[\"G70323CJ\",\"G93575MM\"]" }, { "pathway_label": "Defective B4GALT1 causes CDG-2d", "protein_name": "[{\"label\":\"Beta-1,4-galactosyltransferase 1\",\"id\":\"P15291\"}]", "uniprot_id": "[\"P15291\"]", "gene_symbol": "[\"B4GALT1\",\"GGTB2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IRAK1 recruits IKK complex", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 1\",\"id\":\"Q96FA3\"},{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 2\",\"id\":\"Q9HAT8\"},{\"label\":\"E3 ubiquitin-protein ligase pellino homolog 3\",\"id\":\"Q8N2H9\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 1\",\"id\":\"Q13404\"}]", "uniprot_id": "[\"O14920\",\"O15111\",\"P51617\",\"P61088\",\"Q13404\",\"Q8N2H9\",\"Q96FA3\",\"Q9HAT8\",\"Q9Y4K3\",\"Q9Y6K9\"]", "gene_symbol": "[\"BLU\",\"CHUK\",\"CROC1\",\"FIP3\",\"IKBKB\",\"IKBKG\",\"IKKA\",\"IKKB\",\"IRAK\",\"IRAK1\",\"NEMO\",\"PELI1\",\"PELI2\",\"PELI3\",\"PRISM\",\"RNF85\",\"TCF16\",\"TRAF6\",\"UBE2N\",\"UBE2V\",\"UBE2V1\",\"UEV1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Notch-HLH transcription pathway", "protein_name": "[{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Histone acetyltransferase KAT2A\",\"id\":\"Q92830\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone deacetylase 11\",\"id\":\"Q96DB2\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone deacetylase 2\",\"id\":\"Q92769\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone deacetylase 4\",\"id\":\"P56524\"},{\"label\":\"Histone deacetylase 5\",\"id\":\"Q9UQL6\"},{\"label\":\"Histone deacetylase 6\",\"id\":\"Q9UBN7\"},{\"label\":\"Histone deacetylase 7\",\"id\":\"Q8WUI4\"},{\"label\":\"Histone deacetylase 8\",\"id\":\"Q9BY41\"},{\"label\":\"Histone deacetylase 9\",\"id\":\"Q9UKV0\"},{\"label\":\"Mastermind-like domain-containing protein 1\",\"id\":\"Q13495\"},{\"label\":\"Mastermind-like protein 1\",\"id\":\"Q92585\"},{\"label\":\"Mastermind-like protein 2\",\"id\":\"Q8IZL2\"},{\"label\":\"Mastermind-like protein 3\",\"id\":\"Q96JK9\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Neurogenic locus notch homolog protein 2\",\"id\":\"Q04721\"},{\"label\":\"Neurogenic locus notch homolog protein 3\",\"id\":\"Q9UM47\"},{\"label\":\"Neurogenic locus notch homolog protein 4\",\"id\":\"Q99466\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Polyamine deacetylase HDAC10\",\"id\":\"Q969S8\"},{\"label\":\"Recombining binding protein suppressor of hairless\",\"id\":\"Q06330\"},{\"label\":\"SNW domain-containing protein 1\",\"id\":\"Q13573\"}]", "uniprot_id": "[\"O15379\",\"O60907\",\"O75376\",\"P46531\",\"P56524\",\"Q04721\",\"Q06330\",\"Q13495\",\"Q13547\",\"Q13573\",\"Q8IZL2\",\"Q8WUI4\",\"Q92585\",\"Q92769\",\"Q92793\",\"Q92830\",\"Q92831\",\"Q969S8\",\"Q96DB2\",\"Q96JK9\",\"Q99466\",\"Q9BY41\",\"Q9BZK7\",\"Q9UBN7\",\"Q9UKV0\",\"Q9UM47\",\"Q9UQL6\",\"Q9Y618\"]", "gene_symbol": "[\"CBP\",\"CG1\",\"CREBBP\",\"CTG26\",\"CXorf6\",\"GCN5\",\"GCN5L2\",\"HDAC1\",\"HDAC10\",\"HDAC11\",\"HDAC2\",\"HDAC3\",\"HDAC4\",\"HDAC5\",\"HDAC6\",\"HDAC7\",\"HDAC7A\",\"HDAC7B\",\"HDAC8\",\"HDAC9\",\"HDACL1\",\"HDRP\",\"IGKJRB\",\"IGKJRB1\",\"INT3\",\"IRA1\",\"KAT2A\",\"KAT2B\",\"KIAA0200\",\"KIAA0288\",\"KIAA0600\",\"KIAA0744\",\"KIAA0901\",\"KIAA1047\",\"KIAA1816\",\"KIAA1819\",\"MAML1\",\"MAML2\",\"MAML3\",\"MAMLD1\",\"MITR\",\"NCOR1\",\"NCOR2\",\"NOTCH1\",\"NOTCH2\",\"NOTCH3\",\"NOTCH4\",\"PCAF\",\"RBPJ\",\"RBPJK\",\"RBPSUH\",\"RPD3L1\",\"SKIIP\",\"SKIP\",\"SNW1\",\"TAN1\",\"TBL1\",\"TBL1X\",\"TBL1XR1\",\"TBLR1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nephron development", "protein_name": "[{\"label\":\"Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe\",\"id\":\"Q8NES3\"},{\"label\":\"Delta-like protein 1\",\"id\":\"O00548\"},{\"label\":\"Hepatocyte nuclear factor 1-beta\",\"id\":\"P35680\"},{\"label\":\"Hepatocyte nuclear factor 4-alpha\",\"id\":\"P41235\"},{\"label\":\"Iroquois-class homeodomain protein IRX-1\",\"id\":\"P78414\"},{\"label\":\"Iroquois-class homeodomain protein IRX-2\",\"id\":\"Q9BZI1\"},{\"label\":\"LIM/homeobox protein Lhx1\",\"id\":\"P48742\"},{\"label\":\"POU domain, class 3, transcription factor 3\",\"id\":\"P20264\"},{\"label\":\"Protein Wnt-4\",\"id\":\"P56705\"},{\"label\":\"Protein Wnt-9b\",\"id\":\"O14905\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Wilms tumor protein\",\"id\":\"P19544\"}]", "uniprot_id": "[\"O00548\",\"O14905\",\"P19544\",\"P20264\",\"P35680\",\"P41235\",\"P48742\",\"P56705\",\"P78414\",\"P78504\",\"Q8NES3\",\"Q9BZI1\"]", "gene_symbol": "[\"BRN1\",\"DLL1\",\"HNF1B\",\"HNF4\",\"HNF4A\",\"IRX1\",\"IRX2\",\"IRXA1\",\"IRXA2\",\"JAG1\",\"JAGL1\",\"LFNG\",\"LHX1\",\"LIM-1\",\"LIM1\",\"NR2A1\",\"OTF8\",\"POU3F3\",\"TCF14\",\"TCF2\",\"WNT14B\",\"WNT15\",\"WNT4\",\"WNT9B\",\"WT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Hyaluronan biosynthesis and export", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 5\",\"id\":\"O15440\"},{\"label\":\"Cell migration-inducing and hyaluronan-binding protein\",\"id\":\"Q8WUJ3\"},{\"label\":\"Hyaluronan synthase 1\",\"id\":\"Q92839\"},{\"label\":\"Hyaluronan synthase 2\",\"id\":\"Q92819\"},{\"label\":\"Hyaluronan synthase 3\",\"id\":\"O00219\"}]", "uniprot_id": "[\"O00219\",\"O15440\",\"Q8WUJ3\",\"Q92819\",\"Q92839\"]", "gene_symbol": "[\"ABCC5\",\"CEMIP\",\"HAS\",\"HAS1\",\"HAS2\",\"HAS3\",\"HYBID\",\"KIAA1199\",\"MRP5\"]", "gtc_id": "[\"G35674CY\"]" }, { "pathway_label": "midostaurin-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Integration of viral DNA into host genomic DNA", "protein_name": "[{\"label\":\"Barrier-to-autointegration factor\",\"id\":\"O75531\"},{\"label\":\"Gag polyprotein\",\"id\":\"P04591\"},{\"label\":\"Gag-Pol polyprotein\",\"id\":\"P04585\"},{\"label\":\"High mobility group protein HMG-I/HMG-Y\",\"id\":\"P17096\"},{\"label\":\"PC4 and SFRS1-interacting protein\",\"id\":\"O75475\"},{\"label\":\"Protein Rev\",\"id\":\"P04618\"},{\"label\":\"Protein Vpr\",\"id\":\"P69726\"},{\"label\":\"Protein Vpu\",\"id\":\"P05919\"},{\"label\":\"Virion infectivity factor\",\"id\":\"P69723\"}]", "uniprot_id": "[\"O75475\",\"O75531\",\"P04585\",\"P04591\",\"P04618\",\"P05919\",\"P17096\",\"P69723\",\"P69726\"]", "gene_symbol": "[\"BAF\",\"BANF1\",\"BCRG1\",\"DFS70\",\"HMGA1\",\"HMGIY\",\"LEDGF\",\"PSIP1\",\"PSIP2\",\"gag\",\"gag-pol\",\"rev\",\"vif\",\"vpr\",\"vpu\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling", "protein_name": "[{\"label\":\"Interferon regulatory factor 7\",\"id\":\"Q92985\"},{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"Interleukin-1 receptor-associated kinase 4\",\"id\":\"Q9NWZ3\"},{\"label\":\"Myeloid differentiation primary response protein MyD88\",\"id\":\"Q99836\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Toll-like receptor 7\",\"id\":\"Q9NYK1\"},{\"label\":\"Toll-like receptor 9\",\"id\":\"Q9NR96\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 1\",\"id\":\"Q13404\"}]", "uniprot_id": "[\"P51617\",\"P61088\",\"Q13404\",\"Q92985\",\"Q99836\",\"Q9NR96\",\"Q9NWZ3\",\"Q9NYK1\",\"Q9Y4K3\"]", "gene_symbol": "[\"BLU\",\"CROC1\",\"IRAK\",\"IRAK1\",\"IRAK4\",\"IRF7\",\"MYD88\",\"RNF85\",\"TLR7\",\"TLR9\",\"TRAF6\",\"UBE2N\",\"UBE2V\",\"UBE2V1\",\"UEV1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of RAS in B cells", "protein_name": "[{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"RAS guanyl-releasing protein 1\",\"id\":\"O95267\"},{\"label\":\"Ras guanyl-releasing protein 3\",\"id\":\"Q8IV61\"}]", "uniprot_id": "[\"O95267\",\"P01111\",\"P01112\",\"Q8IV61\"]", "gene_symbol": "[\"GRP3\",\"HRAS\",\"HRAS1\",\"KIAA0846\",\"NRAS\",\"RASGRP\",\"RASGRP1\",\"RASGRP3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Glucagon signaling in metabolic regulation", "protein_name": "[{\"label\":\"Adenylate cyclase type 1\",\"id\":\"Q08828\"},{\"label\":\"Adenylate cyclase type 2\",\"id\":\"Q08462\"},{\"label\":\"Adenylate cyclase type 3\",\"id\":\"O60266\"},{\"label\":\"Adenylate cyclase type 4\",\"id\":\"Q8NFM4\"},{\"label\":\"Adenylate cyclase type 5\",\"id\":\"O95622\"},{\"label\":\"Adenylate cyclase type 6\",\"id\":\"O43306\"},{\"label\":\"Adenylate cyclase type 7\",\"id\":\"P51828\"},{\"label\":\"Adenylate cyclase type 8\",\"id\":\"P40145\"},{\"label\":\"Adenylate cyclase type 9\",\"id\":\"O60503\"},{\"label\":\"Glucagon receptor\",\"id\":\"P47871\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas\",\"id\":\"Q5JWF2\"},{\"label\":\"Guanine nucleotide-binding protein G(s) subunit alpha isoforms short\",\"id\":\"P63092\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Pro-glucagon\",\"id\":\"P01275\"}]", "uniprot_id": "[\"O43306\",\"O60262\",\"O60266\",\"O60503\",\"O95622\",\"P01275\",\"P16520\",\"P40145\",\"P47871\",\"P50150\",\"P50151\",\"P51828\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63092\",\"P63215\",\"P63218\",\"Q08462\",\"Q08828\",\"Q5JWF2\",\"Q8NFM4\",\"Q9HAV0\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": "[\"ADCY1\",\"ADCY2\",\"ADCY3\",\"ADCY4\",\"ADCY5\",\"ADCY6\",\"ADCY7\",\"ADCY8\",\"ADCY9\",\"GCG\",\"GCGR\",\"GNAS\",\"GNAS1\",\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT10\",\"GNGT11\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT9\",\"GSP\",\"KIAA0037\",\"KIAA0422\",\"KIAA0511\",\"KIAA0520\",\"KIAA1060\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1", "protein_name": "[{\"label\":\"Dystroglycan 1\",\"id\":\"Q14118\"},{\"label\":\"Protein O-mannosyl-transferase 1\",\"id\":\"Q9Y6A1\"},{\"label\":\"Protein O-mannosyl-transferase 2\",\"id\":\"Q9UKY4\"}]", "uniprot_id": "[\"Q14118\",\"Q9UKY4\",\"Q9Y6A1\"]", "gene_symbol": "[\"DAG1\",\"POMT1\",\"POMT2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Proton-coupled neutral amino acid transporters", "protein_name": "[{\"label\":\"Proton-coupled amino acid transporter 1\",\"id\":\"Q7Z2H8\"},{\"label\":\"Proton-coupled amino acid transporter 2\",\"id\":\"Q495M3\"}]", "uniprot_id": "[\"Q495M3\",\"Q7Z2H8\"]", "gene_symbol": "[\"PAT1\",\"PAT2\",\"SLC36A1\",\"SLC36A2\",\"TRAMD1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RAF/MAP kinase cascade", "protein_name": "[{\"label\":\"Alpha-actinin-2\",\"id\":\"P35609\"},{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"Angiopoietin-1 receptor\",\"id\":\"Q02763\"},{\"label\":\"Angiopoietin-1\",\"id\":\"Q15389\"},{\"label\":\"Artemin\",\"id\":\"Q5T4W7\"},{\"label\":\"Astrocytic phosphoprotein PEA-15\",\"id\":\"Q15121\"},{\"label\":\"Beta-klotho\",\"id\":\"Q86Z14\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Cytokine receptor common subunit beta\",\"id\":\"P32927\"},{\"label\":\"Cytokine receptor common subunit gamma\",\"id\":\"P31785\"},{\"label\":\"Disks large homolog 1\",\"id\":\"Q12959\"},{\"label\":\"Disks large homolog 2\",\"id\":\"Q15700\"},{\"label\":\"Disks large homolog 3\",\"id\":\"Q92796\"},{\"label\":\"Disks large homolog 4\",\"id\":\"P78352\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Epigen\",\"id\":\"Q6UW88\"},{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 19\",\"id\":\"O95750\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 22\",\"id\":\"Q9HCT0\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 3\",\"id\":\"P11487\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 7\",\"id\":\"P21781\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor 4\",\"id\":\"P22455\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Fibroblast growth factor receptor substrate 3\",\"id\":\"O43559\"},{\"label\":\"Fms-related tyrosine kinase 3 ligand\",\"id\":\"P49771\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"GDNF family receptor alpha-1\",\"id\":\"P56159\"},{\"label\":\"GDNF family receptor alpha-2\",\"id\":\"O00451\"},{\"label\":\"GDNF family receptor alpha-3\",\"id\":\"O60609\"},{\"label\":\"GDNF family receptor alpha-4\",\"id\":\"Q9GZZ7\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Glial cell line-derived neurotrophic factor\",\"id\":\"P39905\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 1\",\"id\":\"Q05586\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2B\",\"id\":\"Q13224\"},{\"label\":\"Glutamate receptor ionotropic, NMDA 2D\",\"id\":\"O15399\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor receptor subunit alpha\",\"id\":\"P15509\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor\",\"id\":\"P04141\"},{\"label\":\"Hepatocyte growth factor receptor\",\"id\":\"P08581\"},{\"label\":\"Hepatocyte growth factor\",\"id\":\"P14210\"},{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Interleukin-2 receptor subunit 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective visual phototransduction due to RDH5 loss of function", "protein_name": "[{\"label\":\"Retinaldehyde-binding protein 1\",\"id\":\"P12271\"},{\"label\":\"Retinol dehydrogenase 5\",\"id\":\"Q92781\"}]", "uniprot_id": "[\"P12271\",\"Q92781\"]", "gene_symbol": "[\"CRALBP\",\"HSD17B9\",\"RDH1\",\"RDH5\",\"RLBP1\",\"SDR9C5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Proton/oligopeptide cotransporters", "protein_name": "[{\"label\":\"Solute carrier family 15 member 1\",\"id\":\"P46059\"},{\"label\":\"Solute carrier family 15 member 3\",\"id\":\"Q8IY34\"},{\"label\":\"Solute carrier family 15 member 4\",\"id\":\"Q8N697\"}]", "uniprot_id": "[\"P46059\",\"Q8IY34\",\"Q8N697\"]", "gene_symbol": "[\"OCTP\",\"PEPT1\",\"PHT1\",\"PHT2\",\"PTR3\",\"PTR4\",\"SLC15A1\",\"SLC15A3\",\"SLC15A4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCD4 causes MAHCJ", "protein_name": "[{\"label\":\"Lysosomal cobalamin transport escort protein LMBD1\",\"id\":\"Q9NUN5\"},{\"label\":\"Lysosomal cobalamin transporter ABCD4\",\"id\":\"O14678\"}]", "uniprot_id": "[\"O14678\",\"Q9NUN5\"]", "gene_symbol": "[\"ABCD4\",\"C6orf209\",\"LMBRD1\",\"NESI\",\"PXMP1L\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of maresin-like SPMs", "protein_name": "[{\"label\":\"Cytochrome P450 1A2\",\"id\":\"P05177\"},{\"label\":\"Cytochrome P450 2C8\",\"id\":\"P10632\"},{\"label\":\"Cytochrome P450 2C9\",\"id\":\"P11712\"},{\"label\":\"Cytochrome P450 2D6\",\"id\":\"P10635\"},{\"label\":\"Cytochrome P450 2E1\",\"id\":\"P05181\"},{\"label\":\"Cytochrome P450 3A4\",\"id\":\"P08684\"}]", "uniprot_id": "[\"P05177\",\"P05181\",\"P08684\",\"P10632\",\"P10635\",\"P11712\"]", "gene_symbol": "[\"CYP1A2\",\"CYP2C10\",\"CYP2C8\",\"CYP2C9\",\"CYP2D6\",\"CYP2DL1\",\"CYP2E\",\"CYP2E1\",\"CYP3A3\",\"CYP3A4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RAC2 GTPase cycle", "protein_name": "[{\"label\":\"ARF GTPase-activating protein 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121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin 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1\",\"id\":\"Q9UQ84\"},{\"label\":\"Fanconi anemia group J protein\",\"id\":\"Q9BX63\"},{\"label\":\"Histone H2AX\",\"id\":\"P16104\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H2B type F-S\",\"id\":\"P57053\"},{\"label\":\"Histone H3.1t\",\"id\":\"Q16695\"},{\"label\":\"Histone 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"gtc_id": "[\"\"]" }, { "pathway_label": "Epithelial-Mesenchymal Transition (EMT) during gastrulation", "protein_name": "[{\"label\":\"Eomesodermin homolog\",\"id\":\"O95936\"},{\"label\":\"Fibroblast growth factor receptor 1\",\"id\":\"P11362\"},{\"label\":\"T-box transcription factor T\",\"id\":\"O15178\"},{\"label\":\"Zinc finger protein SNAI1\",\"id\":\"O95863\"}]", "uniprot_id": "[\"O15178\",\"O95863\",\"O95936\",\"P11362\"]", "gene_symbol": "[\"BFGFR\",\"CEK\",\"EOMES\",\"FGFBR\",\"FGFR1\",\"FLG\",\"FLT2\",\"HBGFR\",\"SNAH\",\"SNAI1\",\"T\",\"TBR2\",\"TBXT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of MITF-M dependent genes involved in metabolism", "protein_name": "[{\"label\":\"NAD-dependent protein deacetylase sirtuin-1\",\"id\":\"Q96EB6\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha\",\"id\":\"Q9UBK2\"}]", "uniprot_id": "[\"Q96EB6\",\"Q9UBK2\"]", "gene_symbol": "[\"LEM6\",\"PGC1\",\"PGC1A\",\"PPARGC1\",\"PPARGC1A\",\"SIR2L1\",\"SIRT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Mitochondrial short-chain enoyl-CoA hydratase deficiency 1", "protein_name": "[{\"label\":\"Enoyl-CoA hydratase, mitochondrial\",\"id\":\"P30084\"}]", "uniprot_id": "[\"P30084\"]", "gene_symbol": "[\"ECHS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2", "protein_name": "[{\"label\":\"Cytochrome P450 1A2\",\"id\":\"P05177\"}]", "uniprot_id": "[\"P05177\"]", "gene_symbol": "[\"CYP1A2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ribavirin ADME", "protein_name": "[{\"label\":\"Adenosine deaminase\",\"id\":\"P00813\"},{\"label\":\"Adenosine kinase\",\"id\":\"P55263\"},{\"label\":\"Cytosolic purine 5'-nucleotidase\",\"id\":\"P49902\"},{\"label\":\"Equilibrative nucleoside transporter 1\",\"id\":\"Q99808\"},{\"label\":\"Equilibrative nucleoside transporter 3\",\"id\":\"Q9BZD2\"},{\"label\":\"Inosine triphosphate pyrophosphatase\",\"id\":\"Q9BY32\"},{\"label\":\"Nucleoside diphosphate kinase A\",\"id\":\"P15531\"},{\"label\":\"Nucleoside diphosphate kinase B\",\"id\":\"P22392\"},{\"label\":\"Purine nucleoside phosphorylase\",\"id\":\"P00491\"},{\"label\":\"Sodium/nucleoside cotransporter 2\",\"id\":\"O43868\"},{\"label\":\"Solute carrier family 28 member 3\",\"id\":\"Q9HAS3\"}]", "uniprot_id": "[\"O43868\",\"P00491\",\"P00813\",\"P15531\",\"P22392\",\"P49902\",\"P55263\",\"Q99808\",\"Q9BY32\",\"Q9BZD2\",\"Q9HAS3\"]", "gene_symbol": "[\"ADA\",\"ADA1\",\"ADK\",\"C20orf37\",\"CNT2\",\"CNT3\",\"ENT1\",\"ENT3\",\"ITPA\",\"NDPKA\",\"NM23\",\"NM23B\",\"NME1\",\"NME2\",\"NP\",\"NT5B\",\"NT5C2\",\"NT5CP\",\"PNP\",\"PNT5\",\"SLC28A2\",\"SLC28A3\",\"SLC29A1\",\"SLC29A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective CHST3 causes SEDCJD", "protein_name": "[{\"label\":\"Biglycan\",\"id\":\"P21810\"},{\"label\":\"Brevican core protein\",\"id\":\"Q96GW7\"},{\"label\":\"Carbohydrate sulfotransferase 3\",\"id\":\"Q7LGC8\"},{\"label\":\"Chondroitin sulfate proteoglycan 4\",\"id\":\"Q6UVK1\"},{\"label\":\"Chondroitin sulfate proteoglycan 5\",\"id\":\"O95196\"},{\"label\":\"Decorin\",\"id\":\"P07585\"},{\"label\":\"Neurocan core protein\",\"id\":\"O14594\"},{\"label\":\"Versican core protein\",\"id\":\"P13611\"}]", "uniprot_id": "[\"O14594\",\"O95196\",\"P07585\",\"P13611\",\"P21810\",\"Q6UVK1\",\"Q7LGC8\",\"Q96GW7\"]", "gene_symbol": "[\"BCAN\",\"BEHAB\",\"BGN\",\"CALEB\",\"CHST3\",\"CSPG2\",\"CSPG3\",\"CSPG4\",\"CSPG5\",\"CSPG7\",\"DCN\",\"MCSP\",\"NCAN\",\"NEUR\",\"NGC\",\"SLRR1A\",\"SLRR1B\",\"VCAN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of NPAS4 mRNA translation", "protein_name": "[{\"label\":\"Helicase MOV-10\",\"id\":\"Q9HCE1\"},{\"label\":\"Neuronal PAS domain-containing protein 4\",\"id\":\"Q8IUM7\"},{\"label\":\"Protein argonaute-1\",\"id\":\"Q9UL18\"},{\"label\":\"Protein argonaute-2\",\"id\":\"Q9UKV8\"},{\"label\":\"Protein 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alpha-5\",\"id\":\"P52294\"},{\"label\":\"Importin subunit alpha-6\",\"id\":\"O15131\"},{\"label\":\"Importin subunit alpha-8\",\"id\":\"A9QM74\"},{\"label\":\"Importin subunit beta-1\",\"id\":\"Q14974\"},{\"label\":\"Interferon regulatory factor 3\",\"id\":\"Q14653\"},{\"label\":\"Interferon-induced GTP-binding protein Mx1\",\"id\":\"P20591\"},{\"label\":\"Interferon-induced GTP-binding protein Mx2\",\"id\":\"P20592\"},{\"label\":\"Interferon-induced protein with tetratricopeptide repeats 1\",\"id\":\"P09914\"},{\"label\":\"Interferon-induced, double-stranded RNA-activated protein kinase\",\"id\":\"P19525\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Non-structural protein 1\",\"id\":\"P03496\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear 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"gtc_id": "[\"\"]" }, { "pathway_label": "Formation of paraxial mesoderm", "protein_name": "[{\"label\":\"Bone morphogenetic protein 4\",\"id\":\"P12644\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Delta-like protein 1\",\"id\":\"O00548\"},{\"label\":\"Delta-like protein 3\",\"id\":\"Q9NYJ7\"},{\"label\":\"Fibroblast growth factor receptor 1\",\"id\":\"P11362\"},{\"label\":\"Histone acetyltransferase KAT2A\",\"id\":\"Q92830\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Mastermind-like domain-containing protein 1\",\"id\":\"Q13495\"},{\"label\":\"Mastermind-like protein 1\",\"id\":\"Q92585\"},{\"label\":\"Mastermind-like protein 2\",\"id\":\"Q8IZL2\"},{\"label\":\"Mastermind-like protein 3\",\"id\":\"Q96JK9\"},{\"label\":\"Mesogenin-1\",\"id\":\"A6NI15\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Noggin\",\"id\":\"Q13253\"},{\"label\":\"Protein Wnt-3a\",\"id\":\"P56704\"},{\"label\":\"Recombining binding protein suppressor of hairless\",\"id\":\"Q06330\"},{\"label\":\"SNW domain-containing protein 1\",\"id\":\"Q13573\"},{\"label\":\"T-box transcription factor T\",\"id\":\"O15178\"},{\"label\":\"T-box transcription factor TBX6\",\"id\":\"O95947\"}]", "uniprot_id": "[\"A6NI15\",\"O00548\",\"O15178\",\"O95947\",\"P11362\",\"P12644\",\"P35222\",\"P46531\",\"P56704\",\"Q06330\",\"Q09472\",\"Q13253\",\"Q13495\",\"Q13573\",\"Q8IZL2\",\"Q92585\",\"Q92793\",\"Q92830\",\"Q92831\",\"Q96JK9\",\"Q9NYJ7\",\"Q9UJU2\"]", "gene_symbol": 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2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O43320\",\"O76093\",\"P05230\",\"P08620\",\"P09038\",\"P0CG47\",\"P0CG48\",\"P22681\",\"P27361\",\"P28482\",\"P31371\",\"P62979\",\"P62987\",\"Q06124\",\"Q8WU20\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": 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1B\",\"id\":\"Q7L9L4\"},{\"label\":\"Nephrocystin-4\",\"id\":\"O75161\"},{\"label\":\"Protein KIBRA\",\"id\":\"Q8IX03\"},{\"label\":\"Protein salvador homolog 1\",\"id\":\"Q9H4B6\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-2\",\"id\":\"O14641\"},{\"label\":\"Serine/threonine-protein kinase 3\",\"id\":\"Q13188\"},{\"label\":\"Serine/threonine-protein kinase 4\",\"id\":\"Q13043\"},{\"label\":\"Serine/threonine-protein kinase LATS1\",\"id\":\"O95835\"},{\"label\":\"Serine/threonine-protein kinase LATS2\",\"id\":\"Q9NRM7\"},{\"label\":\"Tight junction protein ZO-1\",\"id\":\"Q07157\"},{\"label\":\"Tight junction protein ZO-2\",\"id\":\"Q9UDY2\"},{\"label\":\"Transcriptional coactivator YAP1\",\"id\":\"P46937\"},{\"label\":\"WW domain-containing transcription regulator protein 1\",\"id\":\"Q9GZV5\"}]", "uniprot_id": "[\"O14641\",\"O75161\",\"O95835\",\"P31946\",\"P42574\",\"P46937\",\"P62258\",\"Q07157\",\"Q13043\",\"Q13188\",\"Q7L9L4\",\"Q8IX03\",\"Q8IY63\",\"Q9GZV5\",\"Q9H4B6\",\"Q9H8S9\",\"Q9NRM7\",\"Q9UDY2\",\"Q9Y2J4\"]", "gene_symbol": "[\"AMOTL1\",\"AMOTL2\",\"C2orf6\",\"CASP3\",\"CPP32\",\"DVL2\",\"KIAA0673\",\"KIAA0869\",\"KIAA0989\",\"KIBRA\",\"KPM\",\"KRS1\",\"KRS2\",\"LATS1\",\"LATS2\",\"MOB1A\",\"MOB1B\",\"MOB4A\",\"MOB4B\",\"MOBK1B\",\"MOBKL1A\",\"MOBKL1B\",\"MST1\",\"MST2\",\"NPHP4\",\"SAV1\",\"STK3\",\"STK4\",\"TAZ\",\"TJP1\",\"TJP2\",\"WARTS\",\"WW45\",\"WWC1\",\"WWTR1\",\"X104\",\"YAP1\",\"YAP65\",\"YWHAB\",\"YWHAE\",\"ZO1\",\"ZO2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of PG", "protein_name": "[{\"label\":\"5'-3' exonuclease PLD3\",\"id\":\"Q8IV08\"},{\"label\":\"5'-3' exonuclease PLD4\",\"id\":\"Q96BZ4\"},{\"label\":\"CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial\",\"id\":\"Q32NB8\"},{\"label\":\"Mitochondrial cardiolipin hydrolase\",\"id\":\"Q8N2A8\"},{\"label\":\"Phosphatidate cytidylyltransferase 2\",\"id\":\"O95674\"},{\"label\":\"Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1\",\"id\":\"Q8WUK0\"},{\"label\":\"Phospholipase D1\",\"id\":\"Q13393\"},{\"label\":\"Phospholipase D2\",\"id\":\"O14939\"}]", "uniprot_id": "[\"O14939\",\"O95674\",\"Q13393\",\"Q32NB8\",\"Q8IV08\",\"Q8N2A8\",\"Q8WUK0\",\"Q96BZ4\"]", "gene_symbol": "[\"C14orf175\",\"CDS2\",\"MOSP\",\"PGS1\",\"PLD1\",\"PLD2\",\"PLD3\",\"PLD4\",\"PLD6\",\"PLIP\",\"PTPMT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Rap1 signalling", "protein_name": "[{\"label\":\"14-3-3 protein beta/alpha\",\"id\":\"P31946\"},{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"RAF proto-oncogene serine/threonine-protein kinase\",\"id\":\"P04049\"},{\"label\":\"RAS guanyl-releasing protein 1\",\"id\":\"O95267\"},{\"label\":\"RAS guanyl-releasing protein 2\",\"id\":\"Q7LDG7\"},{\"label\":\"Rap guanine nucleotide exchange factor 3\",\"id\":\"O95398\"},{\"label\":\"Rap guanine nucleotide exchange factor 4\",\"id\":\"Q8WZA2\"},{\"label\":\"Rap1 GTPase-activating protein 1\",\"id\":\"P47736\"},{\"label\":\"Rap1 GTPase-activating protein 2\",\"id\":\"Q684P5\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"},{\"label\":\"Signal-induced proliferation-associated protein 1\",\"id\":\"Q96FS4\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"}]", "uniprot_id": "[\"O95267\",\"O95398\",\"P04049\",\"P17612\",\"P22612\",\"P22694\",\"P31946\",\"P47736\",\"P61224\",\"P62834\",\"P63104\",\"Q684P5\",\"Q7LDG7\",\"Q8WZA2\",\"Q96FS4\"]", "gene_symbol": "[\"CDC25L\",\"CGEF1\",\"CGEF2\",\"EPAC\",\"EPAC1\",\"EPAC2\",\"GARNL4\",\"KIAA0474\",\"KIAA1039\",\"KREV1\",\"MCG7\",\"PKACA\",\"PRKACA\",\"PRKACB\",\"PRKACG\",\"RAF\",\"RAF1\",\"RAP1A\",\"RAP1B\",\"RAP1GA1\",\"RAP1GA2\",\"RAP1GAP\",\"RAP1GAP2\",\"RAPGEF3\",\"RAPGEF4\",\"RASGRP\",\"RASGRP1\",\"RASGRP2\",\"SIPA1\",\"SPA1\",\"YWHAB\",\"YWHAZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Tyrosine catabolism", "protein_name": "[{\"label\":\"4-hydroxyphenylpyruvate dioxygenase\",\"id\":\"P32754\"},{\"label\":\"Fumarylacetoacetase\",\"id\":\"P16930\"},{\"label\":\"Homogentisate 1,2-dioxygenase\",\"id\":\"Q93099\"},{\"label\":\"Maleylacetoacetate isomerase\",\"id\":\"O43708\"},{\"label\":\"Tyrosine aminotransferase\",\"id\":\"P17735\"}]", "uniprot_id": "[\"O43708\",\"P16930\",\"P17735\",\"P32754\",\"Q93099\"]", "gene_symbol": "[\"FAH\",\"GSTZ1\",\"HGD\",\"HGO\",\"HPD\",\"MAAI\",\"PPD\",\"TAT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation", "protein_name": "[{\"label\":\"Developmental pluripotency-associated protein 4\",\"id\":\"Q7L190\"},{\"label\":\"Ephrin type-A receptor 1\",\"id\":\"P21709\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Forkhead box protein D3\",\"id\":\"Q9UJU5\"},{\"label\":\"Homeobox protein NANOG\",\"id\":\"Q9H9S0\"},{\"label\":\"POU domain, class 5, transcription factor 1\",\"id\":\"Q01860\"},{\"label\":\"Protein Cripto\",\"id\":\"P13385\"},{\"label\":\"Sal-like protein 1\",\"id\":\"Q9NSC2\"},{\"label\":\"Sal-like protein 4\",\"id\":\"Q9UJQ4\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Transcription factor SOX-2\",\"id\":\"P48431\"},{\"label\":\"Zinc finger protein ZIC 3\",\"id\":\"O60481\"}]", "uniprot_id": "[\"O60481\",\"P09038\",\"P13385\",\"P21709\",\"P40763\",\"P48431\",\"Q01860\",\"Q7L190\",\"Q9H9S0\",\"Q9NSC2\",\"Q9UJQ4\",\"Q9UJU5\"]", "gene_symbol": "[\"APRF\",\"CRIPTO\",\"CRIPTO-1\",\"DPPA4\",\"EPH\",\"EPHA1\",\"EPHT\",\"EPHT1\",\"FGF2\",\"FGFB\",\"FOXD3\",\"HFH2\",\"NANOG\",\"OCT3\",\"OCT4\",\"OTF3\",\"POU5F1\",\"SAL1\",\"SALL1\",\"SALL4\",\"SOX2\",\"STAT3\",\"TDGF1\",\"ZIC3\",\"ZNF203\",\"ZNF794\",\"ZNF797\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TWIK-releated acid-sensitive K+ channel (TASK)", "protein_name": "[{\"label\":\"Potassium channel subfamily K member 3\",\"id\":\"O14649\"},{\"label\":\"Potassium channel subfamily K member 9\",\"id\":\"Q9NPC2\"}]", "uniprot_id": "[\"O14649\",\"Q9NPC2\"]", "gene_symbol": "[\"KCNK3\",\"KCNK9\",\"TASK\",\"TASK1\",\"TASK3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ATF6 (ATF6-alpha) activates chaperones", "protein_name": "[{\"label\":\"Cyclic AMP-dependent transcription factor ATF-6 alpha\",\"id\":\"P18850\"},{\"label\":\"Endoplasmic reticulum chaperone BiP\",\"id\":\"P11021\"},{\"label\":\"Membrane-bound transcription factor site-1 protease\",\"id\":\"Q14703\"},{\"label\":\"Membrane-bound transcription factor site-2 protease\",\"id\":\"O43462\"}]", "uniprot_id": "[\"O43462\",\"P11021\",\"P18850\",\"Q14703\"]", "gene_symbol": "[\"ATF6\",\"GRP78\",\"HSPA5\",\"KIAA0091\",\"MBTPS1\",\"MBTPS2\",\"S1P\",\"S2P\",\"SKI1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)", "protein_name": "[{\"label\":\"Sodium- and chloride-dependent transporter XTRP3\",\"id\":\"Q9NP91\"}]", "uniprot_id": "[\"Q9NP91\"]", "gene_symbol": "[\"SIT1\",\"SLC6A20\",\"XT3\",\"XTRP3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Cross-presentation of soluble exogenous antigens (endosomes)", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"C-type lectin domain family 4 member K\",\"id\":\"Q9UJ71\"},{\"label\":\"C-type mannose receptor 2\",\"id\":\"Q9UBG0\"},{\"label\":\"High affinity immunoglobulin gamma Fc receptor I\",\"id\":\"P12314\"},{\"label\":\"Macrophage mannose receptor 1\",\"id\":\"P22897\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Putative high affinity immunoglobulin gamma Fc receptor IB\",\"id\":\"Q92637\"}]", "uniprot_id": "[\"O00231\",\"O00232\",\"O00487\",\"O14818\",\"O43242\",\"P12314\",\"P17980\",\"P20618\",\"P22897\",\"P25786\",\"P25787\",\"P25788\",\"P25789\",\"P28066\",\"P28070\",\"P28072\",\"P28074\",\"P35998\",\"P43686\",\"P48556\",\"P49720\",\"P49721\",\"P51665\",\"P60896\",\"P60900\",\"P62191\",\"P62195\",\"P62333\",\"Q13200\",\"Q15008\",\"Q16186\",\"Q92637\",\"Q99436\",\"Q99460\",\"Q9UBG0\",\"Q9UJ71\",\"Q9UNM6\"]", "gene_symbol": 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polyprotein\",\"id\":\"P04591\"},{\"label\":\"Glycylpeptide N-tetradecanoyltransferase 2\",\"id\":\"O60551\"},{\"label\":\"Multivesicular body subunit 12A\",\"id\":\"Q96EY5\"},{\"label\":\"Multivesicular body subunit 12B\",\"id\":\"Q9H7P6\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Tumor susceptibility gene 101 protein\",\"id\":\"Q99816\"},{\"label\":\"Ubiquitin-associated protein 1\",\"id\":\"Q9NZ09\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Vacuolar protein sorting-associated protein 28 homolog\",\"id\":\"Q9UK41\"},{\"label\":\"Vacuolar protein sorting-associated protein 37A\",\"id\":\"Q8NEZ2\"},{\"label\":\"Vacuolar protein sorting-associated protein 37B\",\"id\":\"Q9H9H4\"},{\"label\":\"Vacuolar protein sorting-associated protein 37C\",\"id\":\"A5D8V6\"},{\"label\":\"Vacuolar protein sorting-associated protein 37D\",\"id\":\"Q86XT2\"}]", "uniprot_id": "[\"A5D8V6\",\"O60551\",\"P04591\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q86XT2\",\"Q8NEZ2\",\"Q96EY5\",\"Q99816\",\"Q9H7P6\",\"Q9H9H4\",\"Q9NZ09\",\"Q9UK41\"]", "gene_symbol": "[\"C9orf28\",\"CFBP\",\"FAM125A\",\"FAM125B\",\"HCRP1\",\"MVB12A\",\"MVB12B\",\"NMT2\",\"PML39\",\"RPS27A\",\"TSG101\",\"UBA52\",\"UBA80\",\"UBAP1\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"VPS28\",\"VPS37A\",\"VPS37B\",\"VPS37C\",\"VPS37D\",\"WBSCR24\",\"gag\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Ceramide signalling", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"Sphingomyelin phosphodiesterase 2\",\"id\":\"O60906\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 16\",\"id\":\"P08138\"}]", "uniprot_id": "[\"O60906\",\"P01138\",\"P08138\"]", "gene_symbol": "[\"NGF\",\"NGFB\",\"NGFR\",\"SMPD2\",\"TNFRSF16\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RAB GEFs exchange GTP for GDP on RABs", "protein_name": "[{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"ALS2 C-terminal-like protein\",\"id\":\"Q60I27\"},{\"label\":\"Alsin\",\"id\":\"Q96Q42\"},{\"label\":\"Ankyrin repeat domain-containing protein 27\",\"id\":\"Q96NW4\"},{\"label\":\"BLOC-3 complex member HPS1\",\"id\":\"Q92902\"},{\"label\":\"BLOC-3 complex member HPS4\",\"id\":\"Q9NQG7\"},{\"label\":\"C-myc promoter-binding protein\",\"id\":\"Q7Z401\"},{\"label\":\"DENN domain-containing protein 1A\",\"id\":\"Q8TEH3\"},{\"label\":\"DENN domain-containing protein 1B\",\"id\":\"Q6P3S1\"},{\"label\":\"DENN domain-containing protein 1C\",\"id\":\"Q8IV53\"},{\"label\":\"DENN domain-containing protein 2A\",\"id\":\"Q9ULE3\"},{\"label\":\"DENN domain-containing protein 2B\",\"id\":\"P78524\"},{\"label\":\"DENN domain-containing protein 2C\",\"id\":\"Q68D51\"},{\"label\":\"DENN domain-containing protein 2D\",\"id\":\"Q9H6A0\"},{\"label\":\"DENN domain-containing protein 3\",\"id\":\"A2RUS2\"},{\"label\":\"DENN domain-containing protein 4B\",\"id\":\"O75064\"},{\"label\":\"DENN domain-containing protein 4C\",\"id\":\"Q5VZ89\"},{\"label\":\"DENN domain-containing protein 5A\",\"id\":\"Q6IQ26\"},{\"label\":\"DENN domain-containing protein 5B\",\"id\":\"Q6ZUT9\"},{\"label\":\"GTPase-activating protein and VPS9 domain-containing protein 1\",\"id\":\"Q14C86\"},{\"label\":\"Guanine nucleotide exchange factor for Rab-3A\",\"id\":\"Q8TBN0\"},{\"label\":\"Guanine nucleotide exchange factor subunit RIC1\",\"id\":\"Q4ADV7\"},{\"label\":\"Myotubularin-related protein 13\",\"id\":\"Q86WG5\"},{\"label\":\"Myotubularin-related protein 5\",\"id\":\"O95248\"},{\"label\":\"Protein DENND6A\",\"id\":\"Q8IWF6\"},{\"label\":\"Protein DENND6B\",\"id\":\"Q8NEG7\"},{\"label\":\"RAB6A-GEF complex partner protein 2\",\"id\":\"Q92546\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Rab GDP dissociation inhibitor alpha\",\"id\":\"P31150\"},{\"label\":\"Rab GDP dissociation inhibitor beta\",\"id\":\"P50395\"},{\"label\":\"Rab proteins geranylgeranyltransferase component A 1\",\"id\":\"P24386\"},{\"label\":\"Rab proteins geranylgeranyltransferase component A 2\",\"id\":\"P26374\"},{\"label\":\"Rab-3A-interacting protein\",\"id\":\"Q96QF0\"},{\"label\":\"Rab3 GTPase-activating protein catalytic subunit\",\"id\":\"Q15042\"},{\"label\":\"Rab3 GTPase-activating protein non-catalytic subunit\",\"id\":\"Q9H2M9\"},{\"label\":\"Rab5 GDP/GTP exchange factor\",\"id\":\"Q9UJ41\"},{\"label\":\"Ras and Rab interactor 1\",\"id\":\"Q13671\"},{\"label\":\"Ras and Rab interactor 2\",\"id\":\"Q8WYP3\"},{\"label\":\"Ras and Rab interactor 3\",\"id\":\"Q8TB24\"},{\"label\":\"Ras and Rab interactor-like protein\",\"id\":\"Q6ZS11\"},{\"label\":\"Ras-related protein Rab-10\",\"id\":\"P61026\"},{\"label\":\"Ras-related protein Rab-12\",\"id\":\"Q6IQ22\"},{\"label\":\"Ras-related protein Rab-13\",\"id\":\"P51153\"},{\"label\":\"Ras-related protein Rab-14\",\"id\":\"P61106\"},{\"label\":\"Ras-related protein Rab-18\",\"id\":\"Q9NP72\"},{\"label\":\"Ras-related protein Rab-1A\",\"id\":\"P62820\"},{\"label\":\"Ras-related protein Rab-1B\",\"id\":\"Q9H0U4\"},{\"label\":\"Ras-related protein Rab-21\",\"id\":\"Q9UL25\"},{\"label\":\"Ras-related protein Rab-27A\",\"id\":\"P51159\"},{\"label\":\"Ras-related protein Rab-27B\",\"id\":\"O00194\"},{\"label\":\"Ras-related protein Rab-31\",\"id\":\"Q13636\"},{\"label\":\"Ras-related protein Rab-32\",\"id\":\"Q13637\"},{\"label\":\"Ras-related protein Rab-35\",\"id\":\"Q15286\"},{\"label\":\"Ras-related protein Rab-38\",\"id\":\"P57729\"},{\"label\":\"Ras-related protein Rab-39A\",\"id\":\"Q14964\"},{\"label\":\"Ras-related protein Rab-39B\",\"id\":\"Q96DA2\"},{\"label\":\"Ras-related protein Rab-3A\",\"id\":\"P20336\"},{\"label\":\"Ras-related protein Rab-5A\",\"id\":\"P20339\"},{\"label\":\"Ras-related protein Rab-5B\",\"id\":\"P61020\"},{\"label\":\"Ras-related protein Rab-5C\",\"id\":\"P51148\"},{\"label\":\"Ras-related protein Rab-6A\",\"id\":\"P20340\"},{\"label\":\"Ras-related protein Rab-6B\",\"id\":\"Q9NRW1\"},{\"label\":\"Ras-related protein Rab-7a\",\"id\":\"P51149\"},{\"label\":\"Ras-related protein Rab-7b\",\"id\":\"Q96AH8\"},{\"label\":\"Ras-related protein Rab-8A\",\"id\":\"P61006\"},{\"label\":\"Ras-related protein Rab-8B\",\"id\":\"Q92930\"},{\"label\":\"Ras-related protein Rab-9A\",\"id\":\"P51151\"},{\"label\":\"Ras-related protein Rab-9B\",\"id\":\"Q9NP90\"},{\"label\":\"Serine/threonine-protein kinase ULK1\",\"id\":\"O75385\"},{\"label\":\"Trafficking protein particle complex subunit 10\",\"id\":\"P48553\"},{\"label\":\"Trafficking protein particle complex subunit 11\",\"id\":\"Q7Z392\"},{\"label\":\"Trafficking protein particle complex subunit 12\",\"id\":\"Q8WVT3\"},{\"label\":\"Trafficking protein particle complex subunit 13\",\"id\":\"A5PLN9\"},{\"label\":\"Trafficking protein particle complex subunit 1\",\"id\":\"Q9Y5R8\"},{\"label\":\"Trafficking protein particle complex subunit 2-like protein\",\"id\":\"Q9UL33\"},{\"label\":\"Trafficking protein particle complex subunit 2\",\"id\":\"P0DI81\"},{\"label\":\"Trafficking protein particle complex subunit 3\",\"id\":\"O43617\"},{\"label\":\"Trafficking protein particle complex subunit 4\",\"id\":\"Q9Y296\"},{\"label\":\"Trafficking protein particle complex subunit 5\",\"id\":\"Q8IUR0\"},{\"label\":\"Trafficking protein particle complex subunit 6A\",\"id\":\"O75865\"},{\"label\":\"Trafficking protein particle complex subunit 6B\",\"id\":\"Q86SZ2\"},{\"label\":\"Trafficking protein particle complex subunit 8\",\"id\":\"Q9Y2L5\"},{\"label\":\"Trafficking protein particle complex subunit 9\",\"id\":\"Q96Q05\"},{\"label\":\"Vacuolar fusion protein CCZ1 homolog B\",\"id\":\"P86790\"},{\"label\":\"Vacuolar fusion protein CCZ1 homolog\",\"id\":\"P86791\"},{\"label\":\"Vacuolar fusion protein MON1 homolog A\",\"id\":\"Q86VX9\"},{\"label\":\"Vacuolar fusion protein MON1 homolog B\",\"id\":\"Q7L1V2\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Post-chaperonin tubulin folding pathway", "protein_name": "[{\"label\":\"ADP-ribosylation factor-like protein 2\",\"id\":\"P36404\"},{\"label\":\"Putative tubulin-like protein alpha-4B\",\"id\":\"Q9H853\"},{\"label\":\"Tubulin alpha chain-like 3\",\"id\":\"A6NHL2\"},{\"label\":\"Tubulin alpha-1A chain\",\"id\":\"Q71U36\"},{\"label\":\"Tubulin alpha-1B chain\",\"id\":\"P68363\"},{\"label\":\"Tubulin alpha-1C chain\",\"id\":\"Q9BQE3\"},{\"label\":\"Tubulin alpha-3C chain\",\"id\":\"P0DPH7\"},{\"label\":\"Tubulin alpha-3D chain\",\"id\":\"P0DPH8\"},{\"label\":\"Tubulin alpha-3E chain\",\"id\":\"Q6PEY2\"},{\"label\":\"Tubulin alpha-4A chain\",\"id\":\"P68366\"},{\"label\":\"Tubulin alpha-8 chain\",\"id\":\"Q9NY65\"},{\"label\":\"Tubulin beta-1 chain\",\"id\":\"Q9H4B7\"},{\"label\":\"Tubulin beta-2A chain\",\"id\":\"Q13885\"},{\"label\":\"Tubulin beta-2B chain\",\"id\":\"Q9BVA1\"},{\"label\":\"Tubulin beta-3 chain\",\"id\":\"Q13509\"},{\"label\":\"Tubulin beta-4A chain\",\"id\":\"P04350\"},{\"label\":\"Tubulin beta-4B chain\",\"id\":\"P68371\"},{\"label\":\"Tubulin beta-6 chain\",\"id\":\"Q9BUF5\"},{\"label\":\"Tubulin-folding cofactor B\",\"id\":\"Q99426\"},{\"label\":\"Tubulin-specific chaperone A\",\"id\":\"O75347\"},{\"label\":\"Tubulin-specific chaperone C\",\"id\":\"Q15814\"},{\"label\":\"Tubulin-specific chaperone D\",\"id\":\"Q9BTW9\"},{\"label\":\"Tubulin-specific chaperone E\",\"id\":\"Q15813\"}]", "uniprot_id": "[\"A6NHL2\",\"O75347\",\"P04350\",\"P0DPH7\",\"P0DPH8\",\"P36404\",\"P68363\",\"P68366\",\"P68371\",\"Q13509\",\"Q13885\",\"Q15813\",\"Q15814\",\"Q6PEY2\",\"Q71U36\",\"Q99426\",\"Q9BQE3\",\"Q9BTW9\",\"Q9BUF5\",\"Q9BVA1\",\"Q9H4B7\",\"Q9H853\",\"Q9NY65\"]", "gene_symbol": "[\"ARL2\",\"CG22\",\"CKAP1\",\"KIAA0988\",\"SSD1\",\"TBCA\",\"TBCB\",\"TBCC\",\"TBCD\",\"TBCE\",\"TFCD\",\"TUBA1\",\"TUBA1A\",\"TUBA1B\",\"TUBA1C\",\"TUBA2\",\"TUBA3\",\"TUBA3C\",\"TUBA3D\",\"TUBA3E\",\"TUBA4\",\"TUBA4A\",\"TUBA4B\",\"TUBA6\",\"TUBA8\",\"TUBAL2\",\"TUBAL3\",\"TUBB1\",\"TUBB2\",\"TUBB2A\",\"TUBB2B\",\"TUBB2C\",\"TUBB3\",\"TUBB4\",\"TUBB4A\",\"TUBB4B\",\"TUBB5\",\"TUBB6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "XAV939 stabilizes AXIN", "protein_name": "[{\"label\":\"Poly [ADP-ribose] polymerase tankyrase-1\",\"id\":\"O95271\"},{\"label\":\"Poly [ADP-ribose] polymerase tankyrase-2\",\"id\":\"Q9H2K2\"}]", "uniprot_id": "[\"O95271\",\"Q9H2K2\"]", "gene_symbol": "[\"PARP5A\",\"PARP5B\",\"PARPL\",\"TANK2\",\"TIN1\",\"TINF1\",\"TNKL\",\"TNKS\",\"TNKS1\",\"TNKS2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Antigen Presentation: Folding, assembly and peptide loading of class I MHC", "protein_name": "[{\"label\":\"Antigen peptide transporter 1\",\"id\":\"Q03518\"},{\"label\":\"Antigen peptide transporter 2\",\"id\":\"Q03519\"},{\"label\":\"Beclin 1-associated autophagy-related key regulator\",\"id\":\"Q6ZNE5\"},{\"label\":\"Beclin-1\",\"id\":\"Q14457\"},{\"label\":\"Beta-2-microglobulin\",\"id\":\"P61769\"},{\"label\":\"Calnexin\",\"id\":\"P27824\"},{\"label\":\"Calreticulin\",\"id\":\"P27797\"},{\"label\":\"Endoplasmic reticulum aminopeptidase 1\",\"id\":\"Q9NZ08\"},{\"label\":\"Endoplasmic reticulum aminopeptidase 2\",\"id\":\"Q6P179\"},{\"label\":\"Endoplasmic reticulum chaperone BiP\",\"id\":\"P11021\"},{\"label\":\"HLA class I histocompatibility antigen, A alpha chain\",\"id\":\"P04439\"},{\"label\":\"HLA class I histocompatibility antigen, B alpha chain\",\"id\":\"P01889\"},{\"label\":\"HLA class I histocompatibility antigen, C alpha chain\",\"id\":\"P10321\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain E\",\"id\":\"P13747\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain F\",\"id\":\"P30511\"},{\"label\":\"HLA class I histocompatibility antigen, alpha chain G\",\"id\":\"P17693\"},{\"label\":\"ORF8 protein\",\"id\":\"P0DTC8\"},{\"label\":\"Phosphatidylinositol 3-kinase catalytic subunit type 3\",\"id\":\"Q8NEB9\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 4\",\"id\":\"Q99570\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Protein disulfide-isomerase A3\",\"id\":\"P30101\"},{\"label\":\"Protein transport protein Sec23A\",\"id\":\"Q15436\"},{\"label\":\"Protein transport protein Sec24A\",\"id\":\"O95486\"},{\"label\":\"Protein transport protein Sec24B\",\"id\":\"O95487\"},{\"label\":\"Protein transport protein Sec24C\",\"id\":\"P53992\"},{\"label\":\"Protein transport protein Sec24D\",\"id\":\"O94855\"},{\"label\":\"Protein transport protein Sec31A\",\"id\":\"O94979\"},{\"label\":\"Putative HLA class I histocompatibility antigen, alpha chain H\",\"id\":\"P01893\"},{\"label\":\"Small COPII coat GTPase SAR1B\",\"id\":\"Q9Y6B6\"},{\"label\":\"Tapasin\",\"id\":\"O15533\"}]", "uniprot_id": "[\"O15533\",\"O94855\",\"O94979\",\"O95486\",\"O95487\",\"P01889\",\"P01893\",\"P04439\",\"P0DTC8\",\"P10321\",\"P11021\",\"P13747\",\"P17693\",\"P27797\",\"P27824\",\"P30101\",\"P30511\",\"P53992\",\"P55735\",\"P61769\",\"Q03518\",\"Q03519\",\"Q14457\",\"Q15436\",\"Q6P179\",\"Q6ZNE5\",\"Q8NEB9\",\"Q99570\",\"Q9NZ08\",\"Q9Y6B6\"]", "gene_symbol": "[\"8\",\"ABCB2\",\"ABCB3\",\"APPILS\",\"ARTS1\",\"ATG14\",\"ATG14L\",\"B2M\",\"BECN1\",\"CALR\",\"CANX\",\"CRTC\",\"D3S1231E\",\"ERAP1\",\"ERAP2\",\"ERP57\",\"ERP60\",\"GRP58\",\"GRP78\",\"GT197\",\"HLA-5.4\",\"HLA-6.0\",\"HLA-6.2\",\"HLA-A\",\"HLA-B\",\"HLA-C\",\"HLA-E\",\"HLA-F\",\"HLA-G\",\"HLA-H\",\"HLAA\",\"HLAB\",\"HLAC\",\"HLAE\",\"HLAF\",\"HLAG\",\"HLAH\",\"HSPA5\",\"KIAA0079\",\"KIAA0525\",\"KIAA0755\",\"KIAA0831\",\"KIAA0905\",\"LRAP\",\"NGS17\",\"PDIA3\",\"PIK3C3\",\"PIK3R4\",\"PSF1\",\"PSF2\",\"RING11\",\"RING4\",\"SAR1B\",\"SARA2\",\"SARB\",\"SEC13\",\"SEC13A\",\"SEC13L1\",\"SEC13R\",\"SEC23A\",\"SEC24A\",\"SEC24B\",\"SEC24C\",\"SEC24D\",\"SEC31A\",\"SEC31L1\",\"TAP1\",\"TAP2\",\"TAPA\",\"TAPBP\",\"VPS15\",\"VPS34\",\"Y1\",\"Y3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)", "protein_name": "[{\"label\":\"Zinc transporter ZIP4\",\"id\":\"Q6P5W5\"}]", "uniprot_id": "[\"Q6P5W5\"]", "gene_symbol": "[\"SLC39A4\",\"ZIP4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Generation of second messenger molecules", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2\",\"id\":\"P16885\"},{\"label\":\"Actin nucleation-promoting factor WAS\",\"id\":\"P42768\"},{\"label\":\"Ena/VASP-like protein\",\"id\":\"Q9UI08\"},{\"label\":\"FYN-binding protein 1\",\"id\":\"O15117\"},{\"label\":\"GRB2-related adapter protein 2\",\"id\":\"O75791\"},{\"label\":\"HLA class II histocompatibility antigen, DP alpha 1 chain\",\"id\":\"P20036\"},{\"label\":\"HLA class II histocompatibility antigen, DP beta 1 chain\",\"id\":\"P04440\"},{\"label\":\"HLA class II histocompatibility antigen, DQ alpha 1 chain\",\"id\":\"P01909\"},{\"label\":\"HLA class II histocompatibility antigen, DQ alpha 2 chain\",\"id\":\"P01906\"},{\"label\":\"HLA class II histocompatibility antigen, DQ beta 1 chain\",\"id\":\"P01920\"},{\"label\":\"HLA class II histocompatibility antigen, DQ beta 2 chain\",\"id\":\"P05538\"},{\"label\":\"HLA class II histocompatibility antigen, DR alpha chain\",\"id\":\"P01903\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 3 chain\",\"id\":\"P79483\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 4 chain\",\"id\":\"P13762\"},{\"label\":\"HLA class II histocompatibility antigen, DR beta 5 chain\",\"id\":\"Q30154\"},{\"label\":\"HLA class II histocompatibility antigen, DRB1 beta chain\",\"id\":\"P01911\"},{\"label\":\"Immunoglobulin superfamily member 2\",\"id\":\"Q93033\"},{\"label\":\"Linker for activation of T-cells family member 1\",\"id\":\"O43561\"},{\"label\":\"Lymphocyte cytosolic protein 2\",\"id\":\"Q13094\"},{\"label\":\"Protein enabled homolog\",\"id\":\"Q8N8S7\"},{\"label\":\"SH2/SH3 adapter protein NCK1\",\"id\":\"P16333\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"T cell receptor alpha chain constant\",\"id\":\"P01848\"},{\"label\":\"T cell receptor alpha variable 19\",\"id\":\"A0A0A6YYK7\"},{\"label\":\"T cell receptor alpha variable 29/delta variable 5\",\"id\":\"P04437\"},{\"label\":\"T cell receptor alpha variable 8-4\",\"id\":\"P01737\"},{\"label\":\"T cell receptor beta constant 1\",\"id\":\"P01850\"},{\"label\":\"T cell receptor beta variable 12-3\",\"id\":\"P01733\"},{\"label\":\"T cell receptor beta variable 7-9\",\"id\":\"P04435\"},{\"label\":\"T-cell surface glycoprotein CD3 delta chain\",\"id\":\"P04234\"},{\"label\":\"T-cell surface glycoprotein CD3 epsilon chain\",\"id\":\"P07766\"},{\"label\":\"T-cell surface glycoprotein CD3 gamma chain\",\"id\":\"P09693\"},{\"label\":\"T-cell surface glycoprotein CD4\",\"id\":\"P01730\"},{\"label\":\"Tyrosine-protein kinase ITK/TSK\",\"id\":\"Q08881\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"Tyrosine-protein kinase ZAP-70\",\"id\":\"P43403\"},{\"label\":\"Vasodilator-stimulated phosphoprotein\",\"id\":\"P50552\"}]", "uniprot_id": "[\"A0A0A6YYK7\",\"O15117\",\"O43561\",\"O75791\",\"O75914\",\"P01730\",\"P01733\",\"P01737\",\"P01848\",\"P01850\",\"P01903\",\"P01906\",\"P01909\",\"P01911\",\"P01920\",\"P04234\",\"P04435\",\"P04437\",\"P04440\",\"P05538\",\"P06239\",\"P07766\",\"P09693\",\"P13762\",\"P16333\",\"P16885\",\"P19174\",\"P20036\",\"P42768\",\"P43403\",\"P50552\",\"P79483\",\"Q08881\",\"Q13094\",\"Q13153\",\"Q13177\",\"Q30154\",\"Q8N8S7\",\"Q93033\",\"Q9UI08\"]", "gene_symbol": 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protein 1\",\"id\":\"Q9H9A7\"},{\"label\":\"RecQ-mediated genome instability protein 2\",\"id\":\"Q96E14\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"},{\"label\":\"Structure-specific endonuclease subunit SLX1\",\"id\":\"Q9BQ83\"},{\"label\":\"Structure-specific endonuclease subunit SLX4\",\"id\":\"Q8IY92\"}]", "uniprot_id": "[\"A4GXA9\",\"O15315\",\"O43502\",\"O43542\",\"O43543\",\"O60934\",\"O75771\",\"P38398\",\"P49959\",\"P51530\",\"P51587\",\"P54132\",\"P60896\",\"Q06609\",\"Q13315\",\"Q13472\",\"Q14159\",\"Q14191\",\"Q17RS7\",\"Q6PIW4\",\"Q86YC2\",\"Q8IY92\",\"Q92878\",\"Q92993\",\"Q96AY2\",\"Q96B01\",\"Q96E14\",\"Q96NY9\",\"Q99708\",\"Q99728\",\"Q9BQ83\",\"Q9BX63\",\"Q9H9A7\",\"Q9NSG2\",\"Q9UQ84\"]", "gene_symbol": 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1\",\"id\":\"P00973\"},{\"label\":\"2'-5'-oligoadenylate synthase 2\",\"id\":\"P29728\"},{\"label\":\"2'-5'-oligoadenylate synthase 3\",\"id\":\"Q9Y6K5\"},{\"label\":\"2'-5'-oligoadenylate synthase-like protein\",\"id\":\"Q15646\"},{\"label\":\"2-5A-dependent ribonuclease\",\"id\":\"Q05823\"},{\"label\":\"ATP-binding cassette sub-family E member 1\",\"id\":\"P61221\"},{\"label\":\"Bone marrow stromal antigen 2\",\"id\":\"Q10589\"},{\"label\":\"Deoxynucleoside triphosphate triphosphohydrolase SAMHD1\",\"id\":\"Q9Y3Z3\"},{\"label\":\"Double-stranded RNA-specific adenosine deaminase\",\"id\":\"P55265\"},{\"label\":\"Early growth response protein 1\",\"id\":\"P18146\"},{\"label\":\"Guanylate-binding protein 2\",\"id\":\"P32456\"},{\"label\":\"HLA class I histocompatibility antigen, A alpha chain\",\"id\":\"P04439\"},{\"label\":\"HLA class I histocompatibility antigen, B alpha chain\",\"id\":\"P01889\"},{\"label\":\"HLA class I histocompatibility antigen, C alpha 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alpha-6\",\"id\":\"P05013\"},{\"label\":\"Interferon alpha-7\",\"id\":\"P01567\"},{\"label\":\"Interferon alpha-8\",\"id\":\"P32881\"},{\"label\":\"Interferon alpha-inducible protein 27, mitochondrial\",\"id\":\"P40305\"},{\"label\":\"Interferon alpha-inducible protein 6\",\"id\":\"P09912\"},{\"label\":\"Interferon alpha/beta receptor 1\",\"id\":\"P17181\"},{\"label\":\"Interferon beta\",\"id\":\"P01574\"},{\"label\":\"Interferon regulatory factor 1\",\"id\":\"P10914\"},{\"label\":\"Interferon regulatory factor 2\",\"id\":\"P14316\"},{\"label\":\"Interferon regulatory factor 3\",\"id\":\"Q14653\"},{\"label\":\"Interferon regulatory factor 4\",\"id\":\"Q15306\"},{\"label\":\"Interferon regulatory factor 5\",\"id\":\"Q13568\"},{\"label\":\"Interferon regulatory factor 6\",\"id\":\"O14896\"},{\"label\":\"Interferon regulatory factor 7\",\"id\":\"Q92985\"},{\"label\":\"Interferon regulatory factor 8\",\"id\":\"Q02556\"},{\"label\":\"Interferon regulatory factor 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11\",\"id\":\"Q06124\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"},{\"label\":\"Ubiquitin-like protein ISG15\",\"id\":\"P05161\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"XIAP-associated factor 1\",\"id\":\"Q6GPH4\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Ubiquitin-dependent degradation of Cyclin D", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"Cyclin-dependent kinase 4\",\"id\":\"P11802\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Proteasomal ubiquitin receptor ADRM1\",\"id\":\"Q16186\"},{\"label\":\"Proteasome subunit alpha type-1\",\"id\":\"P25786\"},{\"label\":\"Proteasome subunit alpha type-2\",\"id\":\"P25787\"},{\"label\":\"Proteasome subunit alpha type-3\",\"id\":\"P25788\"},{\"label\":\"Proteasome subunit alpha type-4\",\"id\":\"P25789\"},{\"label\":\"Proteasome subunit alpha type-5\",\"id\":\"P28066\"},{\"label\":\"Proteasome subunit alpha type-6\",\"id\":\"P60900\"},{\"label\":\"Proteasome subunit alpha type-7\",\"id\":\"O14818\"},{\"label\":\"Proteasome subunit beta type-1\",\"id\":\"P20618\"},{\"label\":\"Proteasome subunit beta type-2\",\"id\":\"P49721\"},{\"label\":\"Proteasome subunit beta type-3\",\"id\":\"P49720\"},{\"label\":\"Proteasome subunit beta type-4\",\"id\":\"P28070\"},{\"label\":\"Proteasome subunit beta type-5\",\"id\":\"P28074\"},{\"label\":\"Proteasome subunit beta type-6\",\"id\":\"P28072\"},{\"label\":\"Proteasome subunit beta type-7\",\"id\":\"Q99436\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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protein\",\"id\":\"O94813\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"},{\"label\":\"Unconventional myosin-IXb\",\"id\":\"Q13459\"}]", "uniprot_id": "[\"O94813\",\"P61586\",\"Q13459\",\"Q9Y6N7\"]", "gene_symbol": "[\"ARH12\",\"ARHA\",\"DUTT1\",\"MYO9B\",\"MYR5\",\"RHO12\",\"RHOA\",\"ROBO1\",\"SLIL3\",\"SLIT2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "DEx/H-box helicases activate type I IFN and inflammatory cytokines production", "protein_name": "[{\"label\":\"ATP-dependent DNA/RNA helicase DHX36\",\"id\":\"Q9H2U1\"},{\"label\":\"ATP-dependent RNA helicase A\",\"id\":\"Q08211\"},{\"label\":\"Interferon regulatory factor 7\",\"id\":\"Q92985\"},{\"label\":\"Myeloid differentiation primary response protein MyD88\",\"id\":\"Q99836\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": "[\"P19838\",\"Q00653\",\"Q04206\",\"Q08211\",\"Q92985\",\"Q99836\",\"Q9H2U1\"]", "gene_symbol": "[\"DDX36\",\"DDX9\",\"DHX36\",\"DHX9\",\"IRF7\",\"KIAA1488\",\"LKP\",\"LYT10\",\"MLEL1\",\"MYD88\",\"NDH2\",\"NFKB1\",\"NFKB2\",\"NFKB3\",\"RELA\",\"RHAU\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde", "protein_name": "[{\"label\":\"Calcium/calmodulin-dependent protein kinase kinase 1\",\"id\":\"Q8N5S9\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase kinase 2\",\"id\":\"Q96RR4\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type IV\",\"id\":\"Q16566\"},{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Importin subunit alpha-1\",\"id\":\"P52292\"}]", "uniprot_id": "[\"P0DP23\",\"P52292\",\"Q13554\",\"Q13555\",\"Q16566\",\"Q8N5S9\",\"Q96RR4\"]", "gene_symbol": "[\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CAM2\",\"CAMK\",\"CAMK-GR\",\"CAMK-II\",\"CAMK2\",\"CAMK2B\",\"CAMK2G\",\"CAMK4\",\"CAMKB\",\"CAMKG\",\"CAMKIV\",\"CAMKK1\",\"CAMKK2\",\"CAMKKA\",\"CAMKKB\",\"KIAA0787\",\"KPNA2\",\"RCH1\",\"SRP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NF-kB is activated and signals survival", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"NF-kappa-B inhibitor alpha\",\"id\":\"P25963\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Sequestosome-1\",\"id\":\"Q13501\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 16\",\"id\":\"P08138\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O14920\",\"P01138\",\"P08138\",\"P0CG47\",\"P0CG48\",\"P19838\",\"P25963\",\"P51617\",\"P62979\",\"P62987\",\"Q04206\",\"Q13501\",\"Q9Y4K3\"]", "gene_symbol": "[\"IKBA\",\"IKBKB\",\"IKKB\",\"IRAK\",\"IRAK1\",\"MAD3\",\"NFKB1\",\"NFKB3\",\"NFKBI\",\"NFKBIA\",\"NGF\",\"NGFB\",\"NGFR\",\"ORCA\",\"OSIL\",\"RELA\",\"RNF85\",\"RPS27A\",\"SQSTM1\",\"TNFRSF16\",\"TRAF6\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Platelet sensitization by LDL", "protein_name": "[{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Cytosolic phospholipase A2\",\"id\":\"P47712\"},{\"label\":\"Low-density lipoprotein receptor-related protein 8\",\"id\":\"Q14114\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Platelet endothelial cell adhesion molecule\",\"id\":\"P16284\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"Tyrosine-protein kinase Fgr\",\"id\":\"P09769\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"}]", "uniprot_id": "[\"P04114\",\"P09769\",\"P16284\",\"P29350\",\"P30153\",\"P30154\",\"P47712\",\"P62714\",\"P67775\",\"Q06124\",\"Q13362\",\"Q14114\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q16539\"]", "gene_symbol": "[\"APOB\",\"APOER2\",\"CPLA2\",\"CSBP\",\"CSBP1\",\"CSBP2\",\"CSPB1\",\"FGR\",\"HCP\",\"KIAA0044\",\"LRP8\",\"MAPK14\",\"MXI2\",\"PECAM1\",\"PLA2G4\",\"PLA2G4A\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"PTP1C\",\"PTP2C\",\"PTPN11\",\"PTPN6\",\"SAPK2A\",\"SHPTP2\",\"SRC2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RNA Polymerase II HIV Promoter Escape", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIE subunit 1\",\"id\":\"P29083\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"TATA-binding protein-associated factor 2N\",\"id\":\"Q92804\"},{\"label\":\"TATA-box-binding protein\",\"id\":\"P20226\"},{\"label\":\"Transcription initiation factor IIA subunit 1\",\"id\":\"P52655\"},{\"label\":\"Transcription initiation factor IIA subunit 2\",\"id\":\"P52657\"},{\"label\":\"Transcription initiation factor IIB\",\"id\":\"Q00403\"},{\"label\":\"Transcription initiation factor IIE subunit beta\",\"id\":\"P29084\"},{\"label\":\"Transcription initiation factor TFIID subunit 1-like\",\"id\":\"Q8IZX4\"},{\"label\":\"Transcription initiation factor TFIID subunit 10\",\"id\":\"Q12962\"},{\"label\":\"Transcription initiation factor TFIID subunit 11\",\"id\":\"Q15544\"},{\"label\":\"Transcription initiation factor TFIID subunit 12\",\"id\":\"Q16514\"},{\"label\":\"Transcription initiation factor TFIID subunit 13\",\"id\":\"Q15543\"},{\"label\":\"Transcription initiation factor TFIID subunit 1\",\"id\":\"P21675\"},{\"label\":\"Transcription initiation factor TFIID subunit 2\",\"id\":\"Q6P1X5\"},{\"label\":\"Transcription initiation factor TFIID subunit 3\",\"id\":\"Q5VWG9\"},{\"label\":\"Transcription initiation factor TFIID subunit 4\",\"id\":\"O00268\"},{\"label\":\"Transcription initiation factor TFIID subunit 4B\",\"id\":\"Q92750\"},{\"label\":\"Transcription initiation factor TFIID subunit 5\",\"id\":\"Q15542\"},{\"label\":\"Transcription initiation factor TFIID subunit 6\",\"id\":\"P49848\"},{\"label\":\"Transcription initiation factor TFIID subunit 7-like\",\"id\":\"Q5H9L4\"},{\"label\":\"Transcription initiation factor TFIID subunit 7\",\"id\":\"Q15545\"},{\"label\":\"Transcription initiation factor TFIID subunit 9\",\"id\":\"Q16594\"},{\"label\":\"Transcription initiation factor TFIID subunit 9B\",\"id\":\"Q9HBM6\"}]", "uniprot_id": "[\"O00268\",\"O15514\",\"P13984\",\"P18074\",\"P19387\",\"P19388\",\"P19447\",\"P20226\",\"P21675\",\"P24928\",\"P29083\",\"P29084\",\"P30876\",\"P32780\",\"P35269\",\"P36954\",\"P49848\",\"P50613\",\"P51946\",\"P51948\",\"P52434\",\"P52435\",\"P52655\",\"P52657\",\"P53803\",\"P61218\",\"P62487\",\"P62875\",\"Q00403\",\"Q12962\",\"Q13888\",\"Q13889\",\"Q15542\",\"Q15543\",\"Q15544\",\"Q15545\",\"Q16514\",\"Q16594\",\"Q5H9L4\",\"Q5VWG9\",\"Q6P1X5\",\"Q6ZYL4\",\"Q8IZX4\",\"Q92750\",\"Q92759\",\"Q92804\",\"Q9HBM6\"]", "gene_symbol": "[\"BA2R\",\"BTF2\",\"BTF2P44\",\"C6orf175\",\"CAK\",\"CAK1\",\"CAP35\",\"CCG1\",\"CCGS\",\"CCNH\",\"CDK7\",\"CDKN7\",\"CIF150\",\"ERCC2\",\"ERCC3\",\"GTF2A1\",\"GTF2A2\",\"GTF2B\",\"GTF2D1\",\"GTF2E1\",\"GTF2E2\",\"GTF2F1\",\"GTF2F2\",\"GTF2H1\",\"GTF2H2\",\"GTF2H3\",\"GTF2H4\",\"GTF2H5\",\"MAT1\",\"MNAT1\",\"MO15\",\"POLR2\",\"POLR2A\",\"POLR2B\",\"POLR2C\",\"POLR2D\",\"POLR2E\",\"POLR2F\",\"POLR2G\",\"POLR2H\",\"POLR2I\",\"POLR2J\",\"POLR2J1\",\"POLR2K\",\"POLR2L\",\"POLRF\",\"RAP30\",\"RAP74\",\"RBP56\",\"RNF66\",\"RPB7\",\"STK1\",\"TAF1\",\"TAF10\",\"TAF11\",\"TAF12\",\"TAF13\",\"TAF15\",\"TAF1L\",\"TAF2\",\"TAF2A\",\"TAF2B\",\"TAF2C\",\"TAF2C1\",\"TAF2C2\",\"TAF2D\",\"TAF2E\",\"TAF2F\",\"TAF2G\",\"TAF2H\",\"TAF2I\",\"TAF2J\",\"TAF2K\",\"TAF2N\",\"TAF2Q\",\"TAF3\",\"TAF4\",\"TAF4A\",\"TAF4B\",\"TAF5\",\"TAF6\",\"TAF7\",\"TAF7L\",\"TAF9\",\"TAF9B\",\"TAF9L\",\"TAFII105\",\"TAFII130\",\"TAFII135\",\"TAFII18\",\"TAFII20\",\"TAFII30\",\"TAFII31\",\"TAFII55\",\"TAFII70\",\"TBP\",\"TF2A1\",\"TF2A2\",\"TF2B\",\"TF2D\",\"TF2E1\",\"TF2E2\",\"TFIIB\",\"TFIID\",\"TTDA\",\"XPB\",\"XPBC\",\"XPD\",\"XPDC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "APC truncation mutants have impaired AXIN binding", "protein_name": "[{\"label\":\"APC membrane recruitment protein 1\",\"id\":\"Q5JTC6\"},{\"label\":\"Adenomatous polyposis coli protein\",\"id\":\"P25054\"},{\"label\":\"Axin-1\",\"id\":\"O15169\"},{\"label\":\"Casein kinase I isoform alpha\",\"id\":\"P48729\"},{\"label\":\"Glycogen synthase kinase-3 beta\",\"id\":\"P49841\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform\",\"id\":\"Q15172\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform\",\"id\":\"Q15173\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform\",\"id\":\"Q14738\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform\",\"id\":\"Q16537\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform\",\"id\":\"Q13362\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"}]", "uniprot_id": "[\"O15169\",\"P25054\",\"P30153\",\"P30154\",\"P48729\",\"P49841\",\"P62714\",\"P67775\",\"Q13362\",\"Q14738\",\"Q15172\",\"Q15173\",\"Q16537\",\"Q5JTC6\"]", "gene_symbol": "[\"AMER1\",\"APC\",\"AXIN\",\"AXIN1\",\"CSNK1A1\",\"DP2.5\",\"FAM123B\",\"GSK3B\",\"KIAA0044\",\"PPP2CA\",\"PPP2CB\",\"PPP2R1A\",\"PPP2R1B\",\"PPP2R5A\",\"PPP2R5B\",\"PPP2R5C\",\"PPP2R5D\",\"PPP2R5E\",\"WTX\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PPARA activates gene expression", "protein_name": "[{\"label\":\"3'-5' exoribonuclease HELZ2\",\"id\":\"Q9BYK8\"},{\"label\":\"5-aminolevulinate synthase, non-specific, mitochondrial\",\"id\":\"P13196\"},{\"label\":\"Acyl-CoA (8-3)-desaturase\",\"id\":\"O60427\"},{\"label\":\"Angiopoietin-related protein 4\",\"id\":\"Q9BY76\"},{\"label\":\"Angiotensinogen\",\"id\":\"P01019\"},{\"label\":\"Ankyrin repeat domain-containing protein 1\",\"id\":\"Q15327\"},{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Apolipoprotein A-II\",\"id\":\"P02652\"},{\"label\":\"Apolipoprotein A-V\",\"id\":\"Q6Q788\"},{\"label\":\"Aryl hydrocarbon receptor nuclear translocator 2\",\"id\":\"Q9HBZ2\"},{\"label\":\"Aryl hydrocarbon receptor nuclear translocator\",\"id\":\"P27540\"},{\"label\":\"Aryl hydrocarbon receptor repressor\",\"id\":\"A9YTQ3\"},{\"label\":\"Aryl hydrocarbon receptor\",\"id\":\"P35869\"},{\"label\":\"Basic helix-loop-helix ARNT-like protein 1\",\"id\":\"O00327\"},{\"label\":\"Bile acid receptor\",\"id\":\"Q96RI1\"},{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Carnitine O-palmitoyltransferase 1, liver isoform\",\"id\":\"P50416\"},{\"label\":\"Carnitine O-palmitoyltransferase 2, mitochondrial\",\"id\":\"P23786\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 9\",\"id\":\"Q3L8U1\"},{\"label\":\"Circadian locomoter output cycles protein kaput\",\"id\":\"O15516\"},{\"label\":\"Constitutive coactivator of peroxisome proliferator-activated receptor gamma\",\"id\":\"Q96EK7\"},{\"label\":\"Cyclin-C\",\"id\":\"P24863\"},{\"label\":\"Cyclin-dependent kinase 19\",\"id\":\"Q9BWU1\"},{\"label\":\"Cyclin-dependent kinase 8\",\"id\":\"P49336\"},{\"label\":\"Cytochrome P450 1A1\",\"id\":\"P04798\"},{\"label\":\"Cytochrome P450 4A11\",\"id\":\"Q02928\"},{\"label\":\"Cytochrome P450 7A1\",\"id\":\"P22680\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Fatty acid-binding protein, liver\",\"id\":\"P07148\"},{\"label\":\"Four and a half LIM domains protein 2\",\"id\":\"Q14192\"},{\"label\":\"G protein pathway suppressor 2\",\"id\":\"Q13227\"},{\"label\":\"G0/G1 switch protein 2\",\"id\":\"P27469\"},{\"label\":\"Glioma pathogenesis-related protein 1\",\"id\":\"P48060\"},{\"label\":\"Grainyhead-like protein 1 homolog\",\"id\":\"Q9NZI5\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone-arginine methyltransferase CARM1\",\"id\":\"Q86X55\"},{\"label\":\"Hydroxymethylglutaryl-CoA synthase, cytoplasmic\",\"id\":\"Q01581\"},{\"label\":\"Hydroxymethylglutaryl-CoA synthase, mitochondrial\",\"id\":\"P54868\"},{\"label\":\"Long-chain fatty acid transport protein 1\",\"id\":\"Q6PCB7\"},{\"label\":\"Long-chain-fatty-acid--CoA ligase 1\",\"id\":\"P33121\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 10\",\"id\":\"Q9BTT4\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 11\",\"id\":\"Q9P086\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 12\",\"id\":\"Q93074\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 13-like\",\"id\":\"Q71F56\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 13\",\"id\":\"Q9UHV7\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 14\",\"id\":\"O60244\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 15\",\"id\":\"Q96RN5\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 16\",\"id\":\"Q9Y2X0\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 17\",\"id\":\"Q9NVC6\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 18\",\"id\":\"Q9BUE0\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 19\",\"id\":\"A0JLT2\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 1\",\"id\":\"Q15648\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 20\",\"id\":\"Q9H944\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 21\",\"id\":\"Q13503\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 22\",\"id\":\"Q15528\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 23\",\"id\":\"Q9ULK4\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 24\",\"id\":\"O75448\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 25\",\"id\":\"Q71SY5\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 26\",\"id\":\"O95402\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 27\",\"id\":\"Q6P2C8\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 28\",\"id\":\"Q9H204\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 29\",\"id\":\"Q9NX70\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 30\",\"id\":\"Q96HR3\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 31\",\"id\":\"Q9Y3C7\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 4\",\"id\":\"Q9NPJ6\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 6\",\"id\":\"O75586\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 7\",\"id\":\"O43513\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 8\",\"id\":\"Q96G25\"},{\"label\":\"Mediator of RNA polymerase II transcription subunit 9\",\"id\":\"Q9NWA0\"},{\"label\":\"Medium-chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P11310\"},{\"label\":\"Metal regulatory transcription factor 1\",\"id\":\"Q14872\"},{\"label\":\"NADP-dependent malic enzyme\",\"id\":\"P48163\"},{\"label\":\"Neuronal PAS domain-containing protein 2\",\"id\":\"Q99743\"},{\"label\":\"Nuclear receptor ROR-alpha\",\"id\":\"P35398\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Nuclear receptor coactivator 3\",\"id\":\"Q9Y6Q9\"},{\"label\":\"Nuclear receptor coactivator 6\",\"id\":\"Q14686\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Nuclear receptor subfamily 1 group D member 1\",\"id\":\"P20393\"},{\"label\":\"Nuclear respiratory factor 1\",\"id\":\"Q16656\"},{\"label\":\"Nuclear transcription factor Y subunit alpha\",\"id\":\"P23511\"},{\"label\":\"Nuclear transcription factor Y subunit beta\",\"id\":\"P25208\"},{\"label\":\"Nuclear transcription factor Y subunit gamma\",\"id\":\"Q13952\"},{\"label\":\"Oxysterols receptor LXR-alpha\",\"id\":\"Q13133\"},{\"label\":\"Oxysterols receptor LXR-beta\",\"id\":\"P55055\"},{\"label\":\"Perilipin-2\",\"id\":\"Q99541\"},{\"label\":\"Peroxisomal membrane protein 11A\",\"id\":\"O75192\"},{\"label\":\"Peroxisome proliferator-activated receptor alpha\",\"id\":\"Q07869\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha\",\"id\":\"Q9UBK2\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-beta\",\"id\":\"Q86YN6\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma\",\"id\":\"P37231\"},{\"label\":\"Phosphatidylcholine translocator ABCB4\",\"id\":\"P21439\"},{\"label\":\"Phospholipid-transporting ATPase ABCA1\",\"id\":\"O95477\"},{\"label\":\"Platelet glycoprotein 4\",\"id\":\"P16671\"},{\"label\":\"Ral guanine nucleotide dissociation stimulator-like 1\",\"id\":\"Q9NZL6\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Retinoic acid receptor RXR-beta\",\"id\":\"P28702\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM2\",\"id\":\"Q8IVF5\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3\",\"id\":\"Q6STE5\"},{\"label\":\"Squalene synthase\",\"id\":\"P37268\"},{\"label\":\"Steroid hormone receptor ERR1\",\"id\":\"P11474\"},{\"label\":\"Sterol 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protein\",\"id\":\"P54920\"},{\"label\":\"Beta-soluble NSF attachment protein\",\"id\":\"Q9H115\"},{\"label\":\"Centromere-associated protein E\",\"id\":\"Q02224\"},{\"label\":\"Centromere/kinetochore protein zw10 homolog\",\"id\":\"O43264\"},{\"label\":\"Chromosome-associated kinesin KIF4A\",\"id\":\"O95239\"},{\"label\":\"Chromosome-associated kinesin KIF4B\",\"id\":\"Q2VIQ3\"},{\"label\":\"Coatomer subunit alpha\",\"id\":\"P53621\"},{\"label\":\"Coatomer subunit beta'\",\"id\":\"P35606\"},{\"label\":\"Coatomer subunit beta\",\"id\":\"P53618\"},{\"label\":\"Coatomer subunit delta\",\"id\":\"P48444\"},{\"label\":\"Coatomer subunit epsilon\",\"id\":\"O14579\"},{\"label\":\"Coatomer subunit gamma-1\",\"id\":\"Q9Y678\"},{\"label\":\"Coatomer subunit gamma-2\",\"id\":\"Q9UBF2\"},{\"label\":\"Coatomer subunit zeta-1\",\"id\":\"P61923\"},{\"label\":\"Coatomer subunit zeta-2\",\"id\":\"Q9P299\"},{\"label\":\"ER lumen protein-retaining receptor 1\",\"id\":\"P24390\"},{\"label\":\"ER lumen protein-retaining receptor 2\",\"id\":\"P33947\"},{\"label\":\"ER lumen protein-retaining receptor 3\",\"id\":\"O43731\"},{\"label\":\"Gamma-soluble NSF attachment protein\",\"id\":\"Q99747\"},{\"label\":\"Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1\",\"id\":\"Q92538\"},{\"label\":\"Kinesin heavy chain isoform 5A\",\"id\":\"Q12840\"},{\"label\":\"Kinesin light chain 1\",\"id\":\"Q07866\"},{\"label\":\"Kinesin light chain 2\",\"id\":\"Q9H0B6\"},{\"label\":\"Kinesin light chain 3\",\"id\":\"Q6P597\"},{\"label\":\"Kinesin light chain 4\",\"id\":\"Q9NSK0\"},{\"label\":\"Kinesin-1 heavy chain\",\"id\":\"P33176\"},{\"label\":\"Kinesin-associated protein 3\",\"id\":\"Q92845\"},{\"label\":\"Kinesin-like protein (Fragment)\",\"id\":\"Q66K46\"},{\"label\":\"Kinesin-like protein (Fragment)\",\"id\":\"Q6PKD1\"},{\"label\":\"Kinesin-like protein KIF11\",\"id\":\"P52732\"},{\"label\":\"Kinesin-like protein KIF12\",\"id\":\"Q96FN5\"},{\"label\":\"Kinesin-like protein KIF13B\",\"id\":\"Q9NQT8\"},{\"label\":\"Kinesin-like protein KIF15\",\"id\":\"Q9NS87\"},{\"label\":\"Kinesin-like protein KIF16B\",\"id\":\"Q96L93\"},{\"label\":\"Kinesin-like protein KIF18A\",\"id\":\"Q8NI77\"},{\"label\":\"Kinesin-like protein KIF18B\",\"id\":\"Q86Y91\"},{\"label\":\"Kinesin-like protein KIF19\",\"id\":\"Q2TAC6\"},{\"label\":\"Kinesin-like protein KIF1A\",\"id\":\"Q12756\"},{\"label\":\"Kinesin-like protein KIF1B\",\"id\":\"O60333\"},{\"label\":\"Kinesin-like protein KIF1C\",\"id\":\"O43896\"},{\"label\":\"Kinesin-like protein KIF20A\",\"id\":\"O95235\"},{\"label\":\"Kinesin-like protein KIF20B\",\"id\":\"Q96Q89\"},{\"label\":\"Kinesin-like protein KIF21A\",\"id\":\"Q7Z4S6\"},{\"label\":\"Kinesin-like protein KIF21B\",\"id\":\"O75037\"},{\"label\":\"Kinesin-like protein KIF22\",\"id\":\"Q14807\"},{\"label\":\"Kinesin-like protein KIF23\",\"id\":\"Q02241\"},{\"label\":\"Kinesin-like protein KIF25\",\"id\":\"Q9UIL4\"},{\"label\":\"Kinesin-like protein KIF26A\",\"id\":\"Q9ULI4\"},{\"label\":\"Kinesin-like protein KIF26B\",\"id\":\"Q2KJY2\"},{\"label\":\"Kinesin-like protein KIF27\",\"id\":\"Q86VH2\"},{\"label\":\"Kinesin-like protein KIF28P\",\"id\":\"B7ZC32\"},{\"label\":\"Kinesin-like protein KIF2A\",\"id\":\"O00139\"},{\"label\":\"Kinesin-like protein KIF2B\",\"id\":\"Q8N4N8\"},{\"label\":\"Kinesin-like protein KIF2C\",\"id\":\"Q99661\"},{\"label\":\"Kinesin-like protein KIF3A\",\"id\":\"Q9Y496\"},{\"label\":\"Kinesin-like protein KIF3B\",\"id\":\"O15066\"},{\"label\":\"Kinesin-like protein KIF3C\",\"id\":\"O14782\"},{\"label\":\"Kinesin-like protein KIF6\",\"id\":\"Q6ZMV9\"},{\"label\":\"Kinesin-like protein KIF9\",\"id\":\"Q9HAQ2\"},{\"label\":\"Kinesin-like protein KIFC1\",\"id\":\"Q9BW19\"},{\"label\":\"Kinesin-like protein KIFC2\",\"id\":\"Q96AC6\"},{\"label\":\"NBAS subunit of NRZ tethering complex\",\"id\":\"A2RRP1\"},{\"label\":\"RAD50-interacting protein 1\",\"id\":\"Q6NUQ1\"},{\"label\":\"Rac GTPase-activating protein 1\",\"id\":\"Q9H0H5\"},{\"label\":\"Ras-related protein Rab-1A\",\"id\":\"P62820\"},{\"label\":\"Ras-related protein Rab-1B\",\"id\":\"Q9H0U4\"},{\"label\":\"Surfeit locus protein 4\",\"id\":\"O15260\"},{\"label\":\"Syntaxin-18\",\"id\":\"Q9P2W9\"},{\"label\":\"Transmembrane emp24 domain-containing protein 10\",\"id\":\"P49755\"},{\"label\":\"Transmembrane emp24 domain-containing protein 2\",\"id\":\"Q15363\"},{\"label\":\"Transmembrane emp24 domain-containing protein 3\",\"id\":\"Q9Y3Q3\"},{\"label\":\"Transmembrane emp24 domain-containing protein 7\",\"id\":\"Q9Y3B3\"},{\"label\":\"Transmembrane emp24 domain-containing protein 9\",\"id\":\"Q9BVK6\"},{\"label\":\"Vesicle transport protein SEC20\",\"id\":\"Q12981\"},{\"label\":\"Vesicle transport protein USE1\",\"id\":\"Q9NZ43\"},{\"label\":\"Vesicle-fusing ATPase\",\"id\":\"P46459\"},{\"label\":\"Vesicle-trafficking protein SEC22b\",\"id\":\"O75396\"}]", "uniprot_id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gene_symbol": "[\"ARCN1\",\"ARF1\",\"ARF1GAP\",\"ARF2\",\"ARF3\",\"ARF4\",\"ARF5\",\"ARFGAP1\",\"ARFGAP2\",\"ARFGAP3\",\"ATSV\",\"BNIP1\",\"C15orf22\",\"C20orf23\",\"C2orf20\",\"C6orf102\",\"CENPE\",\"COPA\",\"COPB\",\"COPB1\",\"COPB2\",\"COPD\",\"COPE\",\"COPG\",\"COPG1\",\"COPG2\",\"COPZ\",\"COPZ1\",\"COPZ2\",\"EG5\",\"ERD2.1\",\"ERD2.2\",\"ERD23\",\"GAKIN\",\"GBF1\",\"GP25L2\",\"HSET\",\"KDELR1\",\"KDELR2\",\"KDELR3\",\"KIAA0248\",\"KIAA0359\",\"KIAA0449\",\"KIAA0591\",\"KIAA0639\",\"KIAA0706\",\"KIAA1236\",\"KIAA1448\",\"KIAA1478\",\"KIAA1590\",\"KIAA1708\",\"KID\",\"KIF11\",\"KIF12\",\"KIF13B\",\"KIF15\",\"KIF16B\",\"KIF18A\",\"KIF18B\",\"KIF19\",\"KIF1A\",\"KIF1B\",\"KIF1C\",\"KIF2\",\"KIF20A\",\"KIF20B\",\"KIF21A\",\"KIF21B\",\"KIF22\",\"KIF23\",\"KIF25\",\"KIF26A\",\"KIF26B\",\"KIF27\",\"KIF28P\",\"KIF2A\",\"KIF2B\",\"KIF2C\",\"KIF3\",\"KIF3A\",\"KIF3AP\",\"KIF3B\",\"KIF3C\",\"KIF4\",\"KIF4A\",\"KIF4B\",\"KIF5A\",\"KIF5B\",\"KIF5C\",\"KIF6\",\"KIF9\",\"KIFAP3\",\"KIFC1\",\"KIFC2\",\"KLC\",\"KLC1\",\"KLC2\",\"KLC2L\",\"KLC3\",\"KLC4\",\"KLP2\",\"KLP6\",\"KNS\",\"KNS1\",\"KNS2\",\"KNSL1\",\"KNSL2\",\"KNSL3\",\"KNSL4\",\"KNSL5\",\"KNSL6\",\"KNSL7\",\"KNSL8\",\"KRMP1\",\"MGCRACGAP\",\"MKLP1\",\"MKLP2\",\"MPHOSPH1\",\"NAG\",\"NAPA\",\"NAPB\",\"NAPG\",\"NBAS\",\"NIP1\",\"NKHC1\",\"NSF\",\"RAB1\",\"RAB1A\",\"RAB1B\",\"RAB6KIFL\",\"RACGAP1\",\"RINT1\",\"RNP24\",\"SEC20L\",\"SEC22B\",\"SEC22L1\",\"SMAP\",\"SNAPA\",\"SNAPB\",\"SNAPG\",\"SNX23\",\"STX18\",\"SURF-4\",\"SURF4\",\"TMED10\",\"TMED2\",\"TMED3\",\"TMED7\",\"TMED9\",\"TMP21\",\"TRIP5\",\"USE1\",\"USE1L\",\"ZNF289\",\"ZW10\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective B4GALT7 causes EDS, progeroid type", "protein_name": "[{\"label\":\"Agrin\",\"id\":\"O00468\"},{\"label\":\"Basement membrane-specific heparan sulfate proteoglycan core protein\",\"id\":\"P98160\"},{\"label\":\"Beta-1,4-galactosyltransferase 7\",\"id\":\"Q9UBV7\"},{\"label\":\"Biglycan\",\"id\":\"P21810\"},{\"label\":\"Brevican core protein\",\"id\":\"Q96GW7\"},{\"label\":\"Chondroitin sulfate proteoglycan 4\",\"id\":\"Q6UVK1\"},{\"label\":\"Chondroitin sulfate proteoglycan 5\",\"id\":\"O95196\"},{\"label\":\"Decorin\",\"id\":\"P07585\"},{\"label\":\"Glypican-1\",\"id\":\"P35052\"},{\"label\":\"Glypican-2\",\"id\":\"Q8N158\"},{\"label\":\"Glypican-3\",\"id\":\"P51654\"},{\"label\":\"Glypican-4\",\"id\":\"O75487\"},{\"label\":\"Glypican-5\",\"id\":\"P78333\"},{\"label\":\"Glypican-6\",\"id\":\"Q9Y625\"},{\"label\":\"Neurocan core protein\",\"id\":\"O14594\"},{\"label\":\"Syndecan-1\",\"id\":\"P18827\"},{\"label\":\"Syndecan-2\",\"id\":\"P34741\"},{\"label\":\"Syndecan-3\",\"id\":\"O75056\"},{\"label\":\"Syndecan-4\",\"id\":\"P31431\"},{\"label\":\"Versican core protein\",\"id\":\"P13611\"}]", "uniprot_id": "[\"O00468\",\"O14594\",\"O75056\",\"O75487\",\"O95196\",\"P07585\",\"P13611\",\"P18827\",\"P21810\",\"P31431\",\"P34741\",\"P35052\",\"P51654\",\"P78333\",\"P98160\",\"Q6UVK1\",\"Q8N158\",\"Q96GW7\",\"Q9UBV7\",\"Q9Y625\"]", "gene_symbol": "[\"AGRIN\",\"AGRN\",\"B4GALT7\",\"BCAN\",\"BEHAB\",\"BGN\",\"CALEB\",\"CSPG2\",\"CSPG3\",\"CSPG4\",\"CSPG5\",\"CSPG7\",\"DCN\",\"GPC1\",\"GPC2\",\"GPC3\",\"GPC4\",\"GPC5\",\"GPC6\",\"HSPG1\",\"HSPG2\",\"KIAA0468\",\"MCSP\",\"NCAN\",\"NEUR\",\"NGC\",\"OCI5\",\"SDC\",\"SDC1\",\"SDC2\",\"SDC3\",\"SDC4\",\"SLRR1A\",\"SLRR1B\",\"VCAN\",\"XGALT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Glycosphingolipid biosynthesis", "protein_name": "[{\"label\":\"2-hydroxyacylsphingosine 1-beta-galactosyltransferase\",\"id\":\"Q16880\"},{\"label\":\"Alpha-2,8-sialyltransferase 8E\",\"id\":\"O15466\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5\",\"id\":\"Q9BVH7\"},{\"label\":\"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6\",\"id\":\"Q969X2\"},{\"label\":\"Beta-1,3-galactosyltransferase 4\",\"id\":\"O96024\"},{\"label\":\"Beta-1,4 N-acetylgalactosaminyltransferase 1\",\"id\":\"Q00973\"},{\"label\":\"Beta-1,4-galactosyltransferase 5\",\"id\":\"O43286\"},{\"label\":\"Beta-1,4-galactosyltransferase 6\",\"id\":\"Q9UBX8\"},{\"label\":\"CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase\",\"id\":\"Q11203\"},{\"label\":\"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2\",\"id\":\"Q16842\"},{\"label\":\"Ceramide glucosyltransferase\",\"id\":\"Q16739\"},{\"label\":\"Ceramide kinase\",\"id\":\"Q8TCT0\"},{\"label\":\"Galactoside alpha-(1,2)-fucosyltransferase 1\",\"id\":\"P19526\"},{\"label\":\"Galactoside alpha-(1,2)-fucosyltransferase 2\",\"id\":\"Q10981\"},{\"label\":\"Galactosylceramide sulfotransferase\",\"id\":\"Q99999\"},{\"label\":\"Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase\",\"id\":\"Q9BYG0\"},{\"label\":\"Lactosylceramide 4-alpha-galactosyltransferase\",\"id\":\"Q9NPC4\"},{\"label\":\"Lactosylceramide alpha-2,3-sialyltransferase\",\"id\":\"Q9UNP4\"},{\"label\":\"UDP-GalNAc\",\"id\":\"beta-1,3-N-acetylgalactosaminyltransferase 1:O75752\"}]", "uniprot_id": "[\"O15466\",\"O43286\",\"O75752\",\"O96024\",\"P19526\",\"Q00973\",\"Q10981\",\"Q11203\",\"Q16739\",\"Q16842\",\"Q16880\",\"Q8TCT0\",\"Q969X2\",\"Q99999\",\"Q9BVH7\",\"Q9BYG0\",\"Q9NPC4\",\"Q9UBX8\",\"Q9UNP4\"]", "gene_symbol": "[\"A14GALT\",\"A4GALT\",\"A4GALT1\",\"B3GALNT1\",\"B3GALT3\",\"B3GALT4\",\"B3GNT5\",\"B4GALNT1\",\"B4GALT5\",\"B4GALT6\",\"CERK\",\"CGT\",\"CST\",\"FUT1\",\"FUT2\",\"GAL3ST1\",\"GALGT\",\"GALT4\",\"H\",\"HSC\",\"KIAA1646\",\"SEC2\",\"SIAT2\",\"SIAT4B\",\"SIAT6\",\"SIAT7E\",\"SIAT7F\",\"SIAT8E\",\"SIAT9\",\"ST3GAL2\",\"ST3GAL3\",\"ST3GAL5\",\"ST6GALNAC5\",\"ST6GALNAC6\",\"ST8SIA5\",\"UGCG\",\"UGT4\",\"UGT8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Viral Messenger RNA Synthesis", "protein_name": "[{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": 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"[\"AAAS\",\"ADRACALA\",\"C7orf14\",\"CAIN\",\"CAN\",\"CG1\",\"D3S1231E\",\"GTF2F1\",\"GTF2F2\",\"KIAA0023\",\"KIAA0095\",\"KIAA0169\",\"KIAA0197\",\"KIAA0225\",\"KIAA0618\",\"KIAA0791\",\"KIAA0906\",\"MP44\",\"MRNP41\",\"NDC1\",\"NP\",\"NPAP60L\",\"NUP107\",\"NUP120\",\"NUP121\",\"NUP133\",\"NUP153\",\"NUP155\",\"NUP160\",\"NUP188\",\"NUP205\",\"NUP210\",\"NUP214\",\"NUP35\",\"NUP358\",\"NUP37\",\"NUP42\",\"NUP43\",\"NUP50\",\"NUP53\",\"NUP54\",\"NUP62\",\"NUP75\",\"NUP85\",\"NUP88\",\"NUP93\",\"NUPL2\",\"PA\",\"PB1\",\"PB2\",\"PCNT1\",\"POLR2\",\"POLR2A\",\"POLR2B\",\"POLR2C\",\"POLR2D\",\"POLR2E\",\"POLR2F\",\"POLR2G\",\"POLR2H\",\"POLR2I\",\"POLR2J\",\"POLR2J1\",\"POLR2K\",\"POLR2L\",\"POLRF\",\"POM121\",\"POM121A\",\"POM121C\",\"RAE1\",\"RANBP2\",\"RAP30\",\"RAP74\",\"RPB7\",\"SEC13\",\"SEC13A\",\"SEC13L1\",\"SEC13R\",\"TMEM48\",\"TPR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Heme degradation", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family C member 2\",\"id\":\"Q92887\"},{\"label\":\"Albumin\",\"id\":\"P02768\"},{\"label\":\"Beta-glucuronidase\",\"id\":\"Q8VNV4\"},{\"label\":\"Biliverdin reductase A\",\"id\":\"P53004\"},{\"label\":\"Broad substrate specificity ATP-binding cassette transporter ABCG2\",\"id\":\"Q9UNQ0\"},{\"label\":\"Fatty acid-binding protein, liver\",\"id\":\"P07148\"},{\"label\":\"Flavin reductase (NADPH)\",\"id\":\"P30043\"},{\"label\":\"Glutathione S-transferase A1\",\"id\":\"P08263\"},{\"label\":\"Heme oxygenase 1\",\"id\":\"P09601\"},{\"label\":\"Heme oxygenase 2\",\"id\":\"P30519\"},{\"label\":\"Multidrug resistance-associated protein 1\",\"id\":\"P33527\"},{\"label\":\"Solute carrier organic anion transporter family member 1B1\",\"id\":\"Q9Y6L6\"},{\"label\":\"Solute carrier organic anion transporter family member 1B3\",\"id\":\"Q9NPD5\"},{\"label\":\"UDP-glucuronosyltransferase 1A1\",\"id\":\"P22309\"},{\"label\":\"UDP-glucuronosyltransferase 1A4\",\"id\":\"P22310\"}]", "uniprot_id": "[\"P02768\",\"P07148\",\"P08263\",\"P09601\",\"P22309\",\"P22310\",\"P30043\",\"P30519\",\"P33527\",\"P53004\",\"Q8VNV4\",\"Q92887\",\"Q9NPD5\",\"Q9UNQ0\",\"Q9Y6L6\"]", "gene_symbol": "[\"ABCC1\",\"ABCC2\",\"ABCG2\",\"ABCP\",\"ALB\",\"BCRP\",\"BCRP1\",\"BLVR\",\"BLVRA\",\"BLVRB\",\"BVR\",\"CMOAT\",\"CMOAT1\",\"CMRP\",\"FABP1\",\"FABPL\",\"FLR\",\"GNT1\",\"GSTA1\",\"HMOX1\",\"HMOX2\",\"HO\",\"HO1\",\"HO2\",\"LST1\",\"LST2\",\"MRP\",\"MRP1\",\"MRP2\",\"MXR\",\"OATP1B1\",\"OATP1B3\",\"OATP2\",\"OATP8\",\"OATPC\",\"SCAN\",\"SLC21A6\",\"SLC21A8\",\"SLCO1B1\",\"SLCO1B3\",\"UGT1\",\"UGT1A1\",\"UGT1A4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RAF-independent MAPK1/3 activation", "protein_name": "[{\"label\":\"Astrocytic phosphoprotein PEA-15\",\"id\":\"Q15121\"},{\"label\":\"Dual specificity protein phosphatase 10\",\"id\":\"Q9Y6W6\"},{\"label\":\"Dual specificity protein phosphatase 16\",\"id\":\"Q9BY84\"},{\"label\":\"Dual specificity protein phosphatase 1\",\"id\":\"P28562\"},{\"label\":\"Dual specificity protein phosphatase 2\",\"id\":\"Q05923\"},{\"label\":\"Dual specificity protein phosphatase 4\",\"id\":\"Q13115\"},{\"label\":\"Dual specificity protein phosphatase 5\",\"id\":\"Q16690\"},{\"label\":\"Dual specificity protein phosphatase 6\",\"id\":\"Q16828\"},{\"label\":\"Dual specificity protein phosphatase 7\",\"id\":\"Q16829\"},{\"label\":\"Dual specificity protein phosphatase 8\",\"id\":\"Q13202\"},{\"label\":\"Dual specificity protein phosphatase 9\",\"id\":\"Q99956\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"}]", "uniprot_id": "[\"P27361\",\"P28482\",\"P28562\",\"Q05923\",\"Q13115\",\"Q13202\",\"Q15121\",\"Q16690\",\"Q16828\",\"Q16829\",\"Q99956\",\"Q9BY84\",\"Q9Y6W6\"]", "gene_symbol": 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ubiquitin-protein ligase MIB1\",\"id\":\"Q86YT6\"},{\"label\":\"E3 ubiquitin-protein ligase MIB2\",\"id\":\"Q96AX9\"},{\"label\":\"E3 ubiquitin-protein ligase NEURL1\",\"id\":\"O76050\"},{\"label\":\"E3 ubiquitin-protein ligase NEURL1B\",\"id\":\"A8MQ27\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"Gamma-secretase subunit APH-1A\",\"id\":\"Q96BI3\"},{\"label\":\"Gamma-secretase subunit APH-1B\",\"id\":\"Q8WW43\"},{\"label\":\"Gamma-secretase subunit PEN-2\",\"id\":\"Q9NZ42\"},{\"label\":\"Hairy/enhancer-of-split related with YRPW motif protein 1\",\"id\":\"Q9Y5J3\"},{\"label\":\"Hairy/enhancer-of-split related with YRPW motif protein 2\",\"id\":\"Q9UBP5\"},{\"label\":\"Hairy/enhancer-of-split related with YRPW motif-like protein\",\"id\":\"Q9NQ87\"},{\"label\":\"Histone acetyltransferase KAT2A\",\"id\":\"Q92830\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 11\",\"id\":\"Q96DB2\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone deacetylase 2\",\"id\":\"Q92769\"},{\"label\":\"Histone deacetylase 3\",\"id\":\"O15379\"},{\"label\":\"Histone deacetylase 4\",\"id\":\"P56524\"},{\"label\":\"Histone deacetylase 5\",\"id\":\"Q9UQL6\"},{\"label\":\"Histone deacetylase 6\",\"id\":\"Q9UBN7\"},{\"label\":\"Histone deacetylase 7\",\"id\":\"Q8WUI4\"},{\"label\":\"Histone deacetylase 8\",\"id\":\"Q9BY41\"},{\"label\":\"Histone deacetylase 9\",\"id\":\"Q9UKV0\"},{\"label\":\"Mastermind-like domain-containing protein 1\",\"id\":\"Q13495\"},{\"label\":\"Mastermind-like protein 1\",\"id\":\"Q92585\"},{\"label\":\"Mastermind-like protein 2\",\"id\":\"Q8IZL2\"},{\"label\":\"Mastermind-like protein 3\",\"id\":\"Q96JK9\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Nicastrin\",\"id\":\"Q92542\"},{\"label\":\"Nuclear receptor corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor corepressor 2\",\"id\":\"Q9Y618\"},{\"label\":\"Polyamine deacetylase HDAC10\",\"id\":\"Q969S8\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Presenilin-1\",\"id\":\"P49768\"},{\"label\":\"Presenilin-2\",\"id\":\"P49810\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Protein jagged-2\",\"id\":\"Q9Y219\"},{\"label\":\"Recombining binding protein suppressor of hairless\",\"id\":\"Q06330\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"SNW domain-containing protein 1\",\"id\":\"Q13573\"},{\"label\":\"Transcription factor HES-1\",\"id\":\"Q14469\"},{\"label\":\"Transcription factor 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"gtc_id": "[\"\"]" }, { "pathway_label": "Arachidonate production from DAG", "protein_name": "[{\"label\":\"Diacylglycerol lipase-alpha\",\"id\":\"Q9Y4D2\"},{\"label\":\"Diacylglycerol lipase-beta\",\"id\":\"Q8NCG7\"},{\"label\":\"Lysophosphatidylserine lipase ABHD12\",\"id\":\"Q8N2K0\"},{\"label\":\"Monoacylglycerol lipase ABHD6\",\"id\":\"Q9BV23\"},{\"label\":\"Monoglyceride lipase\",\"id\":\"Q99685\"}]", "uniprot_id": "[\"Q8N2K0\",\"Q8NCG7\",\"Q99685\",\"Q9BV23\",\"Q9Y4D2\"]", "gene_symbol": "[\"ABHD12\",\"ABHD6\",\"C11orf11\",\"C20orf22\",\"DAGLA\",\"DAGLB\",\"KIAA0659\",\"MGLL\",\"NSDDR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective LARGE causes MDDGA6 and MDDGB6", "protein_name": "[{\"label\":\"Beta-1,4-glucuronyltransferase 1\",\"id\":\"O43505\"},{\"label\":\"Xylosyl- and glucuronyltransferase LARGE1\",\"id\":\"O95461\"}]", "uniprot_id": "[\"O43505\",\"O95461\"]", "gene_symbol": "[\"B3GNT1\",\"B3GNT6\",\"B4GAT1\",\"KIAA0609\",\"LARGE\",\"LARGE1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Establishment of Sister Chromatid Cohesion", "protein_name": "[{\"label\":\"Cohesin subunit SA-1\",\"id\":\"Q8WVM7\"},{\"label\":\"Cohesin subunit SA-2\",\"id\":\"Q8N3U4\"},{\"label\":\"Double-strand-break repair protein rad21 homolog\",\"id\":\"O60216\"},{\"label\":\"N-acetyltransferase ESCO1\",\"id\":\"Q5FWF5\"},{\"label\":\"N-acetyltransferase ESCO2\",\"id\":\"Q56NI9\"},{\"label\":\"Sister chromatid cohesion protein PDS5 homolog A\",\"id\":\"Q29RF7\"},{\"label\":\"Sister chromatid cohesion protein PDS5 homolog B\",\"id\":\"Q9NTI5\"},{\"label\":\"Sororin\",\"id\":\"Q96FF9\"},{\"label\":\"Structural maintenance of chromosomes protein 1A\",\"id\":\"Q14683\"},{\"label\":\"Structural maintenance of chromosomes protein 3\",\"id\":\"Q9UQE7\"},{\"label\":\"Wings apart-like protein homolog\",\"id\":\"Q7Z5K2\"}]", "uniprot_id": "[\"O60216\",\"Q14683\",\"Q29RF7\",\"Q56NI9\",\"Q5FWF5\",\"Q7Z5K2\",\"Q8N3U4\",\"Q8WVM7\",\"Q96FF9\",\"Q9NTI5\",\"Q9UQE7\"]", "gene_symbol": 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2\",\"id\":\"Q13490\"},{\"label\":\"Caspase-3\",\"id\":\"P42574\"},{\"label\":\"Caspase-6\",\"id\":\"P55212\"},{\"label\":\"Caspase-7\",\"id\":\"P55210\"},{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"Claspin\",\"id\":\"Q9HAW4\"},{\"label\":\"Cytoplasmic tyrosine-protein kinase BMX\",\"id\":\"P51813\"},{\"label\":\"DNA-binding protein SATB1\",\"id\":\"Q01826\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha\",\"id\":\"P49354\"},{\"label\":\"Protein kinase C delta type\",\"id\":\"Q05655\"},{\"label\":\"Protein kinase C theta type\",\"id\":\"Q04759\"},{\"label\":\"Rho-associated protein kinase 1\",\"id\":\"Q13464\"},{\"label\":\"Serine/threonine-protein kinase 24\",\"id\":\"Q9Y6E0\"},{\"label\":\"Serine/threonine-protein kinase 26\",\"id\":\"Q9P289\"}]", "uniprot_id": "[\"P25054\",\"P42574\",\"P49354\",\"P51572\",\"P51813\",\"P55210\",\"P55212\",\"Q01826\",\"Q04759\",\"Q05397\",\"Q05655\",\"Q13464\",\"Q13490\",\"Q14790\",\"Q9HAW4\",\"Q9P289\",\"Q9UKV3\",\"Q9Y6E0\"]", "gene_symbol": "[\"ACIN1\",\"ACINUS\",\"APC\",\"API1\",\"BAP31\",\"BCAP31\",\"BIRC2\",\"BMX\",\"CASP3\",\"CASP6\",\"CASP7\",\"CASP8\",\"CLSPN\",\"CPP32\",\"DP2.5\",\"DXS1357E\",\"FAK\",\"FAK1\",\"FNTA\",\"KIAA0670\",\"MASK\",\"MCH2\",\"MCH3\",\"MCH5\",\"MIHB\",\"MST3\",\"MST4\",\"PKCD\",\"PRKCD\",\"PRKCQ\",\"PRKCT\",\"PTK2\",\"RNF48\",\"ROCK1\",\"SATB1\",\"STK24\",\"STK26\",\"STK3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Sensing of DNA Double Strand Breaks", "protein_name": "[{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Importin subunit alpha-1\",\"id\":\"P52292\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"Serine-protein kinase ATM\",\"id\":\"Q13315\"}]", "uniprot_id": "[\"O60934\",\"P49959\",\"P52292\",\"Q13315\",\"Q92878\",\"Q92993\"]", "gene_symbol": "[\"ATM\",\"HNGS1\",\"HTATIP\",\"KAT5\",\"KPNA2\",\"MRE11\",\"MRE11A\",\"NBN\",\"NBS\",\"NBS1\",\"P95\",\"RAD50\",\"RCH1\",\"SRP1\",\"TIP60\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CREB3 factors activate genes", "protein_name": "[{\"label\":\"CREB3 regulatory factor\",\"id\":\"Q8IUR6\"},{\"label\":\"Cyclic AMP-responsive element-binding protein 3-like protein 1\",\"id\":\"Q96BA8\"},{\"label\":\"Cyclic AMP-responsive element-binding protein 3-like protein 2\",\"id\":\"Q70SY1\"},{\"label\":\"Cyclic AMP-responsive element-binding protein 3-like protein 3\",\"id\":\"Q68CJ9\"},{\"label\":\"Cyclic AMP-responsive element-binding protein 3-like protein 4\",\"id\":\"Q8TEY5\"},{\"label\":\"Cyclic AMP-responsive element-binding protein 3\",\"id\":\"O43889\"},{\"label\":\"Dendritic cell-specific transmembrane protein\",\"id\":\"Q9H295\"},{\"label\":\"Membrane-bound transcription factor site-1 protease\",\"id\":\"Q14703\"},{\"label\":\"Membrane-bound transcription factor site-2 protease\",\"id\":\"O43462\"}]", "uniprot_id": "[\"O43462\",\"O43889\",\"Q14703\",\"Q68CJ9\",\"Q70SY1\",\"Q8IUR6\",\"Q8TEY5\",\"Q96BA8\",\"Q9H295\"]", "gene_symbol": "[\"AIBZIP\",\"BBF2H7\",\"C5orf41\",\"CREB3\",\"CREB3L1\",\"CREB3L2\",\"CREB3L3\",\"CREB3L4\",\"CREB4\",\"CREBH\",\"CREBRF\",\"DCSTAMP\",\"JAL\",\"KIAA0091\",\"LZIP\",\"MBTPS1\",\"MBTPS2\",\"OASIS\",\"S1P\",\"S2P\",\"SKI1\",\"TM7SF4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Transport of organic anions", "protein_name": "[{\"label\":\"Monocarboxylate transporter 8\",\"id\":\"P36021\"},{\"label\":\"Solute carrier organic anion transporter family member 1A2\",\"id\":\"P46721\"},{\"label\":\"Solute carrier organic anion transporter family member 1B1\",\"id\":\"Q9Y6L6\"},{\"label\":\"Solute carrier organic anion transporter family member 1B3\",\"id\":\"Q9NPD5\"},{\"label\":\"Solute carrier organic anion transporter family member 1C1\",\"id\":\"Q9NYB5\"},{\"label\":\"Solute carrier organic anion transporter family member 2A1\",\"id\":\"Q92959\"},{\"label\":\"Solute carrier organic anion transporter family member 2B1\",\"id\":\"O94956\"},{\"label\":\"Solute carrier organic anion transporter family member 4A1\",\"id\":\"Q96BD0\"},{\"label\":\"Solute carrier organic anion transporter family member 4C1\",\"id\":\"Q6ZQN7\"},{\"label\":\"Vasopressin-neurophysin 2-copeptin\",\"id\":\"P01185\"}]", "uniprot_id": "[\"O94956\",\"P01185\",\"P36021\",\"P46721\",\"Q6ZQN7\",\"Q92959\",\"Q96BD0\",\"Q9NPD5\",\"Q9NYB5\",\"Q9Y6L6\"]", "gene_symbol": "[\"ARVP\",\"AVP\",\"KIAA0880\",\"LST1\",\"LST2\",\"MCT7\",\"MCT8\",\"OATP\",\"OATP1\",\"OATP14\",\"OATP1A2\",\"OATP1B1\",\"OATP1B3\",\"OATP1C1\",\"OATP2\",\"OATP2A1\",\"OATP2B1\",\"OATP4A1\",\"OATP4C1\",\"OATP8\",\"OATPB\",\"OATPC\",\"OATPE\",\"OATPF\",\"OATPX\",\"SLC16A2\",\"SLC21A12\",\"SLC21A14\",\"SLC21A2\",\"SLC21A20\",\"SLC21A3\",\"SLC21A6\",\"SLC21A8\",\"SLC21A9\",\"SLCO1A2\",\"SLCO1B1\",\"SLCO1B3\",\"SLCO1C1\",\"SLCO2A1\",\"SLCO2B1\",\"SLCO4A1\",\"SLCO4C1\",\"VP\",\"XPCT\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Calnexin/calreticulin cycle", "protein_name": "[{\"label\":\"Calnexin\",\"id\":\"P27824\"},{\"label\":\"Calreticulin\",\"id\":\"P27797\"},{\"label\":\"Glucosidase 2 subunit beta\",\"id\":\"P14314\"},{\"label\":\"Neutral alpha-glucosidase AB\",\"id\":\"Q14697\"},{\"label\":\"Protein disulfide-isomerase A3\",\"id\":\"P30101\"}]", "uniprot_id": "[\"P14314\",\"P27797\",\"P27824\",\"P30101\",\"Q14697\"]", "gene_symbol": "[\"CALR\",\"CANX\",\"CRTC\",\"ERP57\",\"ERP60\",\"G19P1\",\"G2AN\",\"GANAB\",\"GRP58\",\"KIAA0088\",\"PDIA3\",\"PRKCSH\"]", "gtc_id": "[\"G58161NS\",\"G63035DM\",\"G86385RC\",\"G93575MM\"]" }, { "pathway_label": "ROS and RNS production in phagocytes", "protein_name": "[{\"label\":\"Cytochrome b-245 heavy chain\",\"id\":\"P04839\"},{\"label\":\"Cytochrome b-245 light chain\",\"id\":\"P13498\"},{\"label\":\"Natural resistance-associated macrophage protein 1\",\"id\":\"P49279\"},{\"label\":\"Neutrophil cytosol factor 1\",\"id\":\"P14598\"},{\"label\":\"Neutrophil cytosol factor 2\",\"id\":\"P19878\"},{\"label\":\"Neutrophil cytosol factor 4\",\"id\":\"Q15080\"},{\"label\":\"Nitric oxide synthase 1\",\"id\":\"P29475\"},{\"label\":\"Nitric oxide synthase 3\",\"id\":\"P29474\"},{\"label\":\"Nitric oxide synthase, inducible\",\"id\":\"P35228\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 2\",\"id\":\"P15153\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 1\",\"id\":\"Q93050\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 2\",\"id\":\"Q9Y487\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 3\",\"id\":\"Q13488\"},{\"label\":\"V-type proton ATPase 116 kDa subunit a 4\",\"id\":\"Q9HBG4\"},{\"label\":\"V-type proton ATPase 16 kDa proteolipid subunit c\",\"id\":\"P27449\"},{\"label\":\"V-type proton ATPase 21 kDa proteolipid subunit c''\",\"id\":\"Q99437\"},{\"label\":\"V-type proton ATPase catalytic subunit A\",\"id\":\"P38606\"},{\"label\":\"V-type proton ATPase subunit B, brain isoform\",\"id\":\"P21281\"},{\"label\":\"V-type proton ATPase subunit B, kidney isoform\",\"id\":\"P15313\"},{\"label\":\"V-type proton ATPase subunit C 1\",\"id\":\"P21283\"},{\"label\":\"V-type proton ATPase subunit C 2\",\"id\":\"Q8NEY4\"},{\"label\":\"V-type proton ATPase subunit D\",\"id\":\"Q9Y5K8\"},{\"label\":\"V-type proton ATPase subunit E 1\",\"id\":\"P36543\"},{\"label\":\"V-type proton ATPase subunit E 2\",\"id\":\"Q96A05\"},{\"label\":\"V-type proton ATPase subunit F\",\"id\":\"Q16864\"},{\"label\":\"V-type proton ATPase subunit G 1\",\"id\":\"O75348\"},{\"label\":\"V-type proton ATPase subunit G 2\",\"id\":\"O95670\"},{\"label\":\"V-type proton ATPase subunit G 3\",\"id\":\"Q96LB4\"},{\"label\":\"V-type proton ATPase subunit H\",\"id\":\"Q9UI12\"},{\"label\":\"V-type proton ATPase subunit d 1\",\"id\":\"P61421\"},{\"label\":\"V-type proton ATPase subunit d 2\",\"id\":\"Q8N8Y2\"},{\"label\":\"V-type proton ATPase subunit e 1\",\"id\":\"O15342\"},{\"label\":\"V-type proton ATPase subunit e 2\",\"id\":\"Q8NHE4\"},{\"label\":\"Voltage-gated hydrogen channel 1\",\"id\":\"Q96D96\"}]", "uniprot_id": 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aminoacylation", "protein_name": "[{\"label\":\"Alanine--tRNA ligase, cytoplasmic\",\"id\":\"P49588\"},{\"label\":\"Aminoacyl tRNA synthase complex-interacting multifunctional protein 1\",\"id\":\"Q12904\"},{\"label\":\"Aminoacyl tRNA synthase complex-interacting multifunctional protein 2\",\"id\":\"Q13155\"},{\"label\":\"Arginine--tRNA ligase, cytoplasmic\",\"id\":\"P54136\"},{\"label\":\"Asparagine--tRNA ligase, cytoplasmic\",\"id\":\"O43776\"},{\"label\":\"Aspartate--tRNA ligase, cytoplasmic\",\"id\":\"P14868\"},{\"label\":\"Bifunctional glutamate/proline--tRNA ligase\",\"id\":\"P07814\"},{\"label\":\"Cysteine--tRNA ligase, cytoplasmic\",\"id\":\"P49589\"},{\"label\":\"Eukaryotic translation elongation factor 1 epsilon-1\",\"id\":\"O43324\"},{\"label\":\"Glutamine--tRNA ligase\",\"id\":\"P47897\"},{\"label\":\"Glycine--tRNA ligase\",\"id\":\"P41250\"},{\"label\":\"Histidine--tRNA ligase, cytoplasmic\",\"id\":\"P12081\"},{\"label\":\"Inorganic pyrophosphatase\",\"id\":\"Q15181\"},{\"label\":\"Isoleucine--tRNA ligase, cytoplasmic\",\"id\":\"P41252\"},{\"label\":\"Leucine--tRNA ligase, cytoplasmic\",\"id\":\"Q9P2J5\"},{\"label\":\"Lysine--tRNA ligase\",\"id\":\"Q15046\"},{\"label\":\"Methionine--tRNA ligase, cytoplasmic\",\"id\":\"P56192\"},{\"label\":\"Phenylalanine--tRNA ligase alpha subunit\",\"id\":\"Q9Y285\"},{\"label\":\"Phenylalanine--tRNA ligase beta subunit\",\"id\":\"Q9NSD9\"},{\"label\":\"Serine--tRNA ligase, cytoplasmic\",\"id\":\"P49591\"},{\"label\":\"Threonine--tRNA ligase 1, cytoplasmic\",\"id\":\"P26639\"},{\"label\":\"Tryptophan--tRNA ligase, cytoplasmic\",\"id\":\"P23381\"},{\"label\":\"Tyrosine--tRNA ligase, cytoplasmic\",\"id\":\"P54577\"},{\"label\":\"Valine--tRNA ligase\",\"id\":\"P26640\"}]", "uniprot_id": 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the SLC30 family", "protein_name": "[{\"label\":\"Probable proton-coupled zinc antiporter SLC30A3\",\"id\":\"Q99726\"},{\"label\":\"Proton-coupled zinc antiporter SLC30A1\",\"id\":\"Q9Y6M5\"},{\"label\":\"Proton-coupled zinc antiporter SLC30A2\",\"id\":\"Q9BRI3\"},{\"label\":\"Proton-coupled zinc antiporter SLC30A5\",\"id\":\"Q8TAD4\"},{\"label\":\"Proton-coupled zinc antiporter SLC30A8\",\"id\":\"Q8IWU4\"}]", "uniprot_id": "[\"Q8IWU4\",\"Q8TAD4\",\"Q99726\",\"Q9BRI3\",\"Q9Y6M5\"]", "gene_symbol": "[\"SLC30A1\",\"SLC30A2\",\"SLC30A3\",\"SLC30A5\",\"SLC30A8\",\"ZNT1\",\"ZNT2\",\"ZNT3\",\"ZNT5\",\"ZNT8\",\"ZNTL1\",\"ZTL1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective DNA double strand break response due to BRCA1 loss of function", "protein_name": "[{\"label\":\"BRCA1-associated RING domain protein 1\",\"id\":\"Q99728\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"}]", "uniprot_id": "[\"P38398\",\"Q99728\"]", "gene_symbol": "[\"BARD1\",\"BRCA1\",\"RNF53\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Assembly of collagen fibrils and other multimeric structures", "protein_name": "[{\"label\":\"CD151 antigen\",\"id\":\"P48509\"},{\"label\":\"Cathepsin B\",\"id\":\"P07858\"},{\"label\":\"Cathepsin L2\",\"id\":\"O60911\"},{\"label\":\"Cathepsin S\",\"id\":\"P25774\"},{\"label\":\"Collagen alpha-1(I) chain\",\"id\":\"P02452\"},{\"label\":\"Collagen alpha-1(II) chain\",\"id\":\"P02458\"},{\"label\":\"Collagen alpha-1(III) chain\",\"id\":\"P02461\"},{\"label\":\"Collagen alpha-1(IV) chain\",\"id\":\"P02462\"},{\"label\":\"Collagen alpha-1(IX) chain\",\"id\":\"P20849\"},{\"label\":\"Collagen alpha-1(V) chain\",\"id\":\"P20908\"},{\"label\":\"Collagen alpha-1(VI) chain\",\"id\":\"P12109\"},{\"label\":\"Collagen alpha-1(VIII) chain\",\"id\":\"P27658\"},{\"label\":\"Collagen alpha-1(X) chain\",\"id\":\"Q03692\"},{\"label\":\"Collagen alpha-1(XI) chain\",\"id\":\"P12107\"},{\"label\":\"Collagen alpha-1(XV) chain\",\"id\":\"P39059\"},{\"label\":\"Collagen alpha-1(XVIII) chain\",\"id\":\"P39060\"},{\"label\":\"Collagen alpha-1(XXIV) chain\",\"id\":\"Q17RW2\"},{\"label\":\"Collagen alpha-1(XXVII) chain\",\"id\":\"Q8IZC6\"},{\"label\":\"Collagen alpha-2(I) chain\",\"id\":\"P08123\"},{\"label\":\"Collagen alpha-2(IV) chain\",\"id\":\"P08572\"},{\"label\":\"Collagen alpha-2(IX) chain\",\"id\":\"Q14055\"},{\"label\":\"Collagen alpha-2(V) chain\",\"id\":\"P05997\"},{\"label\":\"Collagen alpha-2(VI) chain\",\"id\":\"P12110\"},{\"label\":\"Collagen alpha-2(VIII) chain\",\"id\":\"P25067\"},{\"label\":\"Collagen alpha-2(XI) chain\",\"id\":\"P13942\"},{\"label\":\"Collagen alpha-3(IV) chain\",\"id\":\"Q01955\"},{\"label\":\"Collagen alpha-3(IX) chain\",\"id\":\"Q14050\"},{\"label\":\"Collagen alpha-3(V) chain\",\"id\":\"P25940\"},{\"label\":\"Collagen alpha-3(VI) chain\",\"id\":\"P12111\"},{\"label\":\"Collagen alpha-4(IV) chain\",\"id\":\"P53420\"},{\"label\":\"Collagen alpha-5(IV) chain\",\"id\":\"P29400\"},{\"label\":\"Collagen alpha-5(VI) chain\",\"id\":\"A8TX70\"},{\"label\":\"Collagen alpha-6(VI) chain\",\"id\":\"A6NMZ7\"},{\"label\":\"Collagenase 3\",\"id\":\"P45452\"},{\"label\":\"Integrin alpha-6\",\"id\":\"P23229\"},{\"label\":\"Integrin beta-4\",\"id\":\"P16144\"},{\"label\":\"Laminin subunit alpha-3\",\"id\":\"Q16787\"},{\"label\":\"Laminin subunit beta-3\",\"id\":\"Q13751\"},{\"label\":\"Laminin subunit gamma-2\",\"id\":\"Q13753\"},{\"label\":\"Matrilysin\",\"id\":\"P09237\"},{\"label\":\"Matrix metalloproteinase-20\",\"id\":\"O60882\"},{\"label\":\"Matrix metalloproteinase-9\",\"id\":\"P14780\"},{\"label\":\"Plectin\",\"id\":\"Q15149\"},{\"label\":\"Procathepsin L\",\"id\":\"P07711\"},{\"label\":\"Stromelysin-1\",\"id\":\"P08254\"}]", "uniprot_id": 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"[\"C3orf7\",\"CATL2\",\"CD151\",\"CLG4B\",\"COL10A1\",\"COL11A1\",\"COL11A2\",\"COL15A1\",\"COL18A1\",\"COL1A1\",\"COL1A2\",\"COL24A1\",\"COL27A1\",\"COL29A1\",\"COL2A1\",\"COL3A1\",\"COL4A1\",\"COL4A2\",\"COL4A3\",\"COL4A4\",\"COL4A5\",\"COL5A1\",\"COL5A2\",\"COL5A3\",\"COL6A1\",\"COL6A2\",\"COL6A3\",\"COL6A5\",\"COL6A6\",\"COL8A1\",\"COL8A2\",\"COL9A1\",\"COL9A2\",\"COL9A3\",\"COLL6\",\"CPSB\",\"CTSB\",\"CTSL\",\"CTSL1\",\"CTSL2\",\"CTSS\",\"CTSU\",\"CTSV\",\"ITGA6\",\"ITGB4\",\"KIAA1870\",\"LAMA3\",\"LAMB2T\",\"LAMB3\",\"LAMC2\",\"LAMNA\",\"LAMNB1\",\"LAMNB2\",\"MMP13\",\"MMP20\",\"MMP3\",\"MMP7\",\"MMP9\",\"MPSL1\",\"PLEC\",\"PLEC1\",\"PUMP1\",\"STMY1\",\"TSPAN24\",\"VWA4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G2/M DNA replication checkpoint", "protein_name": "[{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"G2/mitotic-specific cyclin-B2\",\"id\":\"O95067\"},{\"label\":\"Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase\",\"id\":\"Q99640\"},{\"label\":\"Wee1-like protein kinase\",\"id\":\"P30291\"}]", "uniprot_id": "[\"O95067\",\"P06493\",\"P14635\",\"P30291\",\"Q99640\"]", "gene_symbol": "[\"CCNB\",\"CCNB1\",\"CCNB2\",\"CDC2\",\"CDC28A\",\"CDK1\",\"CDKN1\",\"MYT1\",\"P34CDC2\",\"PKMYT1\",\"WEE1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of TP53 Expression", "protein_name": "[{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"PR domain zinc finger protein 1\",\"id\":\"O75626\"}]", "uniprot_id": "[\"O75626\",\"P04637\"]", "gene_symbol": "[\"BLIMP1\",\"P53\",\"PRDM1\",\"TP53\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Downstream signal transduction", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"Adapter molecule crk\",\"id\":\"P46108\"},{\"label\":\"Breast cancer anti-estrogen resistance protein 1\",\"id\":\"P56945\"},{\"label\":\"Crk-like protein\",\"id\":\"P46109\"},{\"label\":\"Cytoplasmic protein NCK2\",\"id\":\"O43639\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Growth factor receptor-bound protein 7\",\"id\":\"Q14451\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Platelet-derived growth factor receptor alpha\",\"id\":\"P16234\"},{\"label\":\"Platelet-derived growth factor receptor beta\",\"id\":\"P09619\"},{\"label\":\"Platelet-derived growth factor subunit B\",\"id\":\"P01127\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Rap guanine nucleotide exchange factor 1\",\"id\":\"Q13905\"},{\"label\":\"Ras GTPase-activating protein 1\",\"id\":\"P20936\"},{\"label\":\"SH2/SH3 adapter protein NCK1\",\"id\":\"P16333\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Signal transducer and activator of transcription 6\",\"id\":\"P42226\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": 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member 5\",\"id\":\"O15440\"},{\"label\":\"Equilibrative nucleoside transporter 1\",\"id\":\"Q99808\"},{\"label\":\"Equilibrative nucleoside transporter 2\",\"id\":\"Q14542\"},{\"label\":\"GMP synthase [glutamine-hydrolyzing]\",\"id\":\"P49915\"},{\"label\":\"Glutathione S-transferase A1\",\"id\":\"P08263\"},{\"label\":\"Glutathione S-transferase A2\",\"id\":\"P09210\"},{\"label\":\"Glutathione S-transferase Mu 1\",\"id\":\"P09488\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Guanine nucleotide exchange factor VAV3\",\"id\":\"Q9UKW4\"},{\"label\":\"Guanylate kinase\",\"id\":\"Q16774\"},{\"label\":\"Hypoxanthine-guanine phosphoribosyltransferase\",\"id\":\"P00492\"},{\"label\":\"Inosine-5'-monophosphate dehydrogenase 1\",\"id\":\"P20839\"},{\"label\":\"Inosine-5'-monophosphate dehydrogenase 2\",\"id\":\"P12268\"},{\"label\":\"Nucleoside diphosphate kinase A\",\"id\":\"P15531\"},{\"label\":\"Nucleoside diphosphate kinase B\",\"id\":\"P22392\"},{\"label\":\"Nucleotide triphosphate diphosphatase NUDT15\",\"id\":\"Q9NV35\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Sodium/nucleoside cotransporter 2\",\"id\":\"O43868\"},{\"label\":\"Solute carrier family 28 member 3\",\"id\":\"Q9HAS3\"},{\"label\":\"Thiopurine S-methyltransferase\",\"id\":\"P51580\"},{\"label\":\"Xanthine dehydrogenase/oxidase\",\"id\":\"P47989\"}]", "uniprot_id": "[\"O15439\",\"O15440\",\"O43868\",\"P00492\",\"P08263\",\"P09210\",\"P09488\",\"P12268\",\"P15498\",\"P15531\",\"P20839\",\"P22392\",\"P47989\",\"P49915\",\"P51580\",\"P52735\",\"P63000\",\"Q14542\",\"Q16774\",\"Q99808\",\"Q9HAS3\",\"Q9NV35\",\"Q9UKW4\"]", "gene_symbol": "[\"ABCC4\",\"ABCC5\",\"CNT2\",\"CNT3\",\"DER12\",\"ENT1\",\"ENT2\",\"GMK\",\"GMPK\",\"GMPS\",\"GST1\",\"GST2\",\"GSTA1\",\"GSTA2\",\"GSTM1\",\"GUK1\",\"HNP36\",\"HPRT\",\"HPRT1\",\"IMPD1\",\"IMPD2\",\"IMPDH1\",\"IMPDH2\",\"MOATB\",\"MRP4\",\"MRP5\",\"MTH2\",\"NDPKA\",\"NM23\",\"NM23B\",\"NME1\",\"NME2\",\"NUDT15\",\"RAC1\",\"SLC28A2\",\"SLC28A3\",\"SLC29A1\",\"SLC29A2\",\"TC25\",\"TPMT\",\"VAV\",\"VAV1\",\"VAV2\",\"VAV3\",\"XDH\",\"XDHA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Proton-coupled monocarboxylate transport", "protein_name": "[{\"label\":\"Basigin\",\"id\":\"P35613\"},{\"label\":\"Embigin\",\"id\":\"Q6PCB8\"},{\"label\":\"Monocarboxylate transporter 1\",\"id\":\"P53985\"},{\"label\":\"Monocarboxylate transporter 2\",\"id\":\"O60669\"},{\"label\":\"Monocarboxylate transporter 3\",\"id\":\"O95907\"},{\"label\":\"Monocarboxylate transporter 4\",\"id\":\"O15427\"}]", "uniprot_id": "[\"O15427\",\"O60669\",\"O95907\",\"P35613\",\"P53985\",\"Q6PCB8\"]", "gene_symbol": "[\"BSG\",\"EMB\",\"MCT1\",\"MCT2\",\"MCT3\",\"MCT4\",\"SLC16A1\",\"SLC16A3\",\"SLC16A7\",\"SLC16A8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Dual incision in TC-NER", "protein_name": "[{\"label\":\"CDK-activating kinase assembly factor MAT1\",\"id\":\"P51948\"},{\"label\":\"Cullin-4A\",\"id\":\"Q13619\"},{\"label\":\"Cullin-4B\",\"id\":\"Q13620\"},{\"label\":\"Cyclin-H\",\"id\":\"P51946\"},{\"label\":\"Cyclin-dependent kinase 7\",\"id\":\"P50613\"},{\"label\":\"DNA damage-binding protein 1\",\"id\":\"Q16531\"},{\"label\":\"DNA excision repair protein ERCC-1\",\"id\":\"P07992\"},{\"label\":\"DNA excision repair protein ERCC-5\",\"id\":\"P28715\"},{\"label\":\"DNA excision repair protein ERCC-6\",\"id\":\"Q03468\"},{\"label\":\"DNA excision repair protein ERCC-8\",\"id\":\"Q13216\"},{\"label\":\"DNA polymerase delta catalytic subunit\",\"id\":\"P28340\"},{\"label\":\"DNA polymerase delta subunit 2\",\"id\":\"P49005\"},{\"label\":\"DNA polymerase delta subunit 3\",\"id\":\"Q15054\"},{\"label\":\"DNA polymerase delta subunit 4\",\"id\":\"Q9HCU8\"},{\"label\":\"DNA polymerase epsilon catalytic subunit A\",\"id\":\"Q07864\"},{\"label\":\"DNA polymerase epsilon subunit 2\",\"id\":\"P56282\"},{\"label\":\"DNA polymerase epsilon subunit 3\",\"id\":\"Q9NRF9\"},{\"label\":\"DNA polymerase epsilon subunit 4\",\"id\":\"Q9NR33\"},{\"label\":\"DNA polymerase kappa\",\"id\":\"Q9UBT6\"},{\"label\":\"DNA repair endonuclease XPF\",\"id\":\"Q92889\"},{\"label\":\"DNA repair protein complementing XP-A cells\",\"id\":\"P23025\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase E\",\"id\":\"Q9UNP9\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Pre-mRNA-processing factor 19\",\"id\":\"Q9UMS4\"},{\"label\":\"Pre-mRNA-splicing factor ISY1 homolog\",\"id\":\"Q9ULR0\"},{\"label\":\"Pre-mRNA-splicing factor SYF1\",\"id\":\"Q9HCS7\"},{\"label\":\"Proliferating cell nuclear antigen\",\"id\":\"P12004\"},{\"label\":\"RNA helicase aquarius\",\"id\":\"O60306\"},{\"label\":\"Replication factor C subunit 1\",\"id\":\"P35251\"},{\"label\":\"Replication factor C subunit 2\",\"id\":\"P35250\"},{\"label\":\"Replication factor C subunit 3\",\"id\":\"P40938\"},{\"label\":\"Replication factor C subunit 4\",\"id\":\"P35249\"},{\"label\":\"Replication factor C subunit 5\",\"id\":\"P40937\"},{\"label\":\"Replication protein A 14 kDa subunit\",\"id\":\"P35244\"},{\"label\":\"Replication protein A 32 kDa subunit\",\"id\":\"P15927\"},{\"label\":\"Replication protein A 70 kDa DNA-binding subunit\",\"id\":\"P27694\"},{\"label\":\"Transcription elongation factor A protein 1\",\"id\":\"P23193\"},{\"label\":\"UV-stimulated scaffold protein A\",\"id\":\"Q2YD98\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 7\",\"id\":\"Q93009\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Zinc finger protein 830\",\"id\":\"Q96NB3\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Respiratory syncytial virus genome replication", "protein_name": "[{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03418\"},{\"label\":\"Phosphoprotein\",\"id\":\"P03421\"},{\"label\":\"Protein M2-1\",\"id\":\"P04545\"},{\"label\":\"Protein M2-2\",\"id\":\"P88812\"},{\"label\":\"RNA-directed RNA polymerase L\",\"id\":\"P28887\"}]", "uniprot_id": "[\"P03418\",\"P03421\",\"P04545\",\"P07900\",\"P08238\",\"P28887\",\"P88812\"]", "gene_symbol": "[\"HSP90A\",\"HSP90AA1\",\"HSP90AB1\",\"HSP90B\",\"HSPC1\",\"HSPC2\",\"HSPC3\",\"HSPCA\",\"HSPCB\",\"L\",\"M2-1\",\"M2-2\",\"N\",\"P\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of G protein gated Potassium channels", "protein_name": "[{\"label\":\"ATP-sensitive inward rectifier potassium channel 10\",\"id\":\"P78508\"},{\"label\":\"ATP-sensitive inward rectifier potassium channel 12\",\"id\":\"Q14500\"},{\"label\":\"ATP-sensitive inward rectifier potassium channel 15\",\"id\":\"Q99712\"},{\"label\":\"G protein-activated inward rectifier potassium channel 1\",\"id\":\"P48549\"},{\"label\":\"G protein-activated inward rectifier potassium channel 2\",\"id\":\"P48051\"},{\"label\":\"G protein-activated inward rectifier potassium channel 3\",\"id\":\"Q92806\"},{\"label\":\"G protein-activated inward rectifier potassium channel 4\",\"id\":\"P48544\"},{\"label\":\"Gamma-aminobutyric acid type B receptor subunit 1\",\"id\":\"Q9UBS5\"},{\"label\":\"Gamma-aminobutyric acid type B receptor subunit 2\",\"id\":\"O75899\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Inward rectifier potassium channel 16\",\"id\":\"Q9NPI9\"},{\"label\":\"Inward rectifier potassium channel 2\",\"id\":\"P63252\"},{\"label\":\"Inward rectifier potassium channel 4\",\"id\":\"P48050\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O60262\",\"O75899\",\"P16520\",\"P48050\",\"P48051\",\"P48544\",\"P48549\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63211\",\"P63215\",\"P63218\",\"P63252\",\"P78508\",\"Q14500\",\"Q92806\",\"Q99712\",\"Q9HAV0\",\"Q9NPI9\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UBS5\",\"Q9UK08\"]", "gene_symbol": "[\"GABBR1\",\"GABBR2\",\"GIRK1\",\"GIRK2\",\"GIRK3\",\"GIRK4\",\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNB5\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT1\",\"GNGT10\",\"GNGT11\",\"GNGT2\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT8\",\"GNGT9\",\"GPR51\",\"GPRC3A\",\"GPRC3B\",\"IRK1\",\"IRK2\",\"IRK3\",\"KATP2\",\"KCNJ10\",\"KCNJ12\",\"KCNJ14\",\"KCNJ15\",\"KCNJ16\",\"KCNJ2\",\"KCNJ3\",\"KCNJ4\",\"KCNJ5\",\"KCNJ6\",\"KCNJ7\",\"KCNJ9\",\"KCNJN1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Class C/3 (Metabotropic glutamate/pheromone receptors)", "protein_name": "[{\"label\":\"Extracellular calcium-sensing receptor\",\"id\":\"P41180\"},{\"label\":\"G-protein coupled receptor family C group 6 member A\",\"id\":\"Q5T6X5\"},{\"label\":\"Gamma-aminobutyric acid type B receptor subunit 1\",\"id\":\"Q9UBS5\"},{\"label\":\"Gamma-aminobutyric acid type B receptor subunit 2\",\"id\":\"O75899\"},{\"label\":\"Metabotropic glutamate receptor 1\",\"id\":\"Q13255\"},{\"label\":\"Metabotropic glutamate receptor 2\",\"id\":\"Q14416\"},{\"label\":\"Metabotropic glutamate receptor 3\",\"id\":\"Q14832\"},{\"label\":\"Metabotropic glutamate receptor 4\",\"id\":\"Q14833\"},{\"label\":\"Metabotropic glutamate receptor 5\",\"id\":\"P41594\"},{\"label\":\"Metabotropic glutamate receptor 6\",\"id\":\"O15303\"},{\"label\":\"Metabotropic glutamate receptor 7\",\"id\":\"Q14831\"},{\"label\":\"Metabotropic glutamate receptor 8\",\"id\":\"O00222\"},{\"label\":\"Taste receptor type 1 member 1\",\"id\":\"Q7RTX1\"},{\"label\":\"Taste receptor type 1 member 2\",\"id\":\"Q8TE23\"},{\"label\":\"Taste receptor type 1 member 3\",\"id\":\"Q7RTX0\"},{\"label\":\"Taste receptor type 2 member 10\",\"id\":\"Q9NYW0\"},{\"label\":\"Taste receptor type 2 member 13\",\"id\":\"Q9NYV9\"},{\"label\":\"Taste receptor type 2 member 14\",\"id\":\"Q9NYV8\"},{\"label\":\"Taste receptor type 2 member 16\",\"id\":\"Q9NYV7\"},{\"label\":\"Taste receptor type 2 member 19\",\"id\":\"P59542\"},{\"label\":\"Taste receptor type 2 member 1\",\"id\":\"Q9NYW7\"},{\"label\":\"Taste receptor type 2 member 20\",\"id\":\"P59543\"},{\"label\":\"Taste receptor type 2 member 30\",\"id\":\"P59541\"},{\"label\":\"Taste receptor type 2 member 31\",\"id\":\"P59538\"},{\"label\":\"Taste receptor type 2 member 38\",\"id\":\"P59533\"},{\"label\":\"Taste receptor type 2 member 39\",\"id\":\"P59534\"},{\"label\":\"Taste receptor type 2 member 3\",\"id\":\"Q9NYW6\"},{\"label\":\"Taste receptor type 2 member 40\",\"id\":\"P59535\"},{\"label\":\"Taste receptor type 2 member 41\",\"id\":\"P59536\"},{\"label\":\"Taste receptor type 2 member 42\",\"id\":\"Q7RTR8\"},{\"label\":\"Taste receptor type 2 member 43\",\"id\":\"P59537\"},{\"label\":\"Taste receptor type 2 member 45\",\"id\":\"P59539\"},{\"label\":\"Taste receptor type 2 member 46\",\"id\":\"P59540\"},{\"label\":\"Taste receptor type 2 member 4\",\"id\":\"Q9NYW5\"},{\"label\":\"Taste receptor type 2 member 50\",\"id\":\"P59544\"},{\"label\":\"Taste receptor type 2 member 5\",\"id\":\"Q9NYW4\"},{\"label\":\"Taste receptor type 2 member 60\",\"id\":\"P59551\"},{\"label\":\"Taste receptor type 2 member 7\",\"id\":\"Q9NYW3\"},{\"label\":\"Taste receptor type 2 member 8\",\"id\":\"Q9NYW2\"},{\"label\":\"Taste receptor type 2 member 9\",\"id\":\"Q9NYW1\"}]", "uniprot_id": "[\"O00222\",\"O15303\",\"O75899\",\"P41180\",\"P41594\",\"P59533\",\"P59534\",\"P59535\",\"P59536\",\"P59537\",\"P59538\",\"P59539\",\"P59540\",\"P59541\",\"P59542\",\"P59543\",\"P59544\",\"P59551\",\"Q13255\",\"Q14416\",\"Q14831\",\"Q14832\",\"Q14833\",\"Q5T6X5\",\"Q7RTR8\",\"Q7RTX0\",\"Q7RTX1\",\"Q8TE23\",\"Q9NYV7\",\"Q9NYV8\",\"Q9NYV9\",\"Q9NYW0\",\"Q9NYW1\",\"Q9NYW2\",\"Q9NYW3\",\"Q9NYW4\",\"Q9NYW5\",\"Q9NYW6\",\"Q9NYW7\",\"Q9UBS5\"]", "gene_symbol": "[\"CASR\",\"GABBR1\",\"GABBR2\",\"GPR51\",\"GPR59\",\"GPR60\",\"GPR70\",\"GPR71\",\"GPRC1A\",\"GPRC1B\",\"GPRC1C\",\"GPRC1D\",\"GPRC1E\",\"GPRC1F\",\"GPRC1G\",\"GPRC1H\",\"GPRC2A\",\"GPRC3A\",\"GPRC3B\",\"GPRC6A\",\"GRM1\",\"GRM2\",\"GRM3\",\"GRM4\",\"GRM5\",\"GRM6\",\"GRM7\",\"GRM8\",\"MGLUR1\",\"MGLUR2\",\"MGLUR3\",\"MGLUR4\",\"MGLUR5\",\"MGLUR6\",\"MGLUR7\",\"MGLUR8\",\"PCAR1\",\"PTC\",\"T1R1\",\"T1R2\",\"T1R3\",\"TAS1R1\",\"TAS1R2\",\"TAS1R3\",\"TAS2R1\",\"TAS2R10\",\"TAS2R13\",\"TAS2R14\",\"TAS2R16\",\"TAS2R19\",\"TAS2R20\",\"TAS2R23\",\"TAS2R3\",\"TAS2R30\",\"TAS2R31\",\"TAS2R38\",\"TAS2R39\",\"TAS2R4\",\"TAS2R40\",\"TAS2R41\",\"TAS2R42\",\"TAS2R43\",\"TAS2R44\",\"TAS2R45\",\"TAS2R46\",\"TAS2R47\",\"TAS2R48\",\"TAS2R49\",\"TAS2R5\",\"TAS2R50\",\"TAS2R55\",\"TAS2R60\",\"TAS2R7\",\"TAS2R8\",\"TAS2R9\",\"TR1\",\"TR2\",\"TR3\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "Tie2 Signaling", "protein_name": "[{\"label\":\"Angiopoietin-1 receptor\",\"id\":\"Q02763\"},{\"label\":\"Angiopoietin-1\",\"id\":\"Q15389\"},{\"label\":\"Angiopoietin-2\",\"id\":\"O15123\"},{\"label\":\"Angiopoietin-4\",\"id\":\"Q9Y264\"},{\"label\":\"Docking protein 2\",\"id\":\"O60496\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Growth factor receptor-bound protein 14\",\"id\":\"Q14449\"},{\"label\":\"Growth factor receptor-bound protein 7\",\"id\":\"Q14451\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O00459\",\"O15123\",\"O60496\",\"P01111\",\"P01112\",\"P27986\",\"P29353\",\"P42336\",\"P42338\",\"Q02763\",\"Q06124\",\"Q07889\",\"Q14449\",\"Q14451\",\"Q15389\",\"Q9Y264\"]", "gene_symbol": "[\"ANG3\",\"ANG4\",\"ANGPT1\",\"ANGPT2\",\"ANGPT4\",\"DOK2\",\"GRB1\",\"GRB14\",\"GRB7\",\"HRAS\",\"HRAS1\",\"KIAA0003\",\"NRAS\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3R1\",\"PIK3R2\",\"PTP2C\",\"PTPN11\",\"SHC\",\"SHC1\",\"SHCA\",\"SHPTP2\",\"SOS1\",\"TEK\",\"TIE2\",\"VMCM\",\"VMCM1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of wybutosine at G37 of tRNA(Phe)", "protein_name": "[{\"label\":\"S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1\",\"id\":\"Q9NV66\"},{\"label\":\"tRNA (guanine(37)-N1)-methyltransferase\",\"id\":\"Q32P41\"},{\"label\":\"tRNA wybutosine-synthesizing protein 2 homolog\",\"id\":\"Q53H54\"},{\"label\":\"tRNA wybutosine-synthesizing protein 3 homolog\",\"id\":\"Q6IPR3\"},{\"label\":\"tRNA wybutosine-synthesizing protein 4\",\"id\":\"O60294\"},{\"label\":\"tRNA wybutosine-synthesizing protein 5\",\"id\":\"A2RUC4\"}]", "uniprot_id": "[\"A2RUC4\",\"O60294\",\"Q32P41\",\"Q53H54\",\"Q6IPR3\",\"Q9NV66\"]", "gene_symbol": "[\"C1orf171\",\"C2orf60\",\"KIAA0547\",\"KIAA1393\",\"LCMT2\",\"RSAFD1\",\"TRM12\",\"TRM5\",\"TRMT12\",\"TRMT5\",\"TYW1\",\"TYW2\",\"TYW3\",\"TYW4\",\"TYW5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PTK6 Regulates Cell Cycle", "protein_name": "[{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase 4\",\"id\":\"P11802\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"G1/S-specific cyclin-E1\",\"id\":\"P24864\"},{\"label\":\"Protein-tyrosine kinase 6\",\"id\":\"Q13882\"}]", "uniprot_id": 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RBBP8\",\"id\":\"Q99708\"},{\"label\":\"DNA repair protein RAD50\",\"id\":\"Q92878\"},{\"label\":\"DNA repair protein RAD51 homolog 1\",\"id\":\"Q06609\"},{\"label\":\"DNA repair protein RAD51 homolog 2\",\"id\":\"O15315\"},{\"label\":\"DNA repair protein RAD51 homolog 3\",\"id\":\"O43502\"},{\"label\":\"DNA repair protein RAD51 homolog 4\",\"id\":\"O75771\"},{\"label\":\"DNA repair protein XRCC2\",\"id\":\"O43543\"},{\"label\":\"DNA repair protein XRCC3\",\"id\":\"O43542\"},{\"label\":\"DNA replication ATP-dependent helicase/nuclease DNA2\",\"id\":\"P51530\"},{\"label\":\"DNA topoisomerase 3-alpha\",\"id\":\"Q13472\"},{\"label\":\"Double-strand break repair protein MRE11\",\"id\":\"P49959\"},{\"label\":\"Exonuclease 1\",\"id\":\"Q9UQ84\"},{\"label\":\"Fanconi anemia group J protein\",\"id\":\"Q9BX63\"},{\"label\":\"Histone acetyltransferase KAT5\",\"id\":\"Q92993\"},{\"label\":\"Nibrin\",\"id\":\"O60934\"},{\"label\":\"Partner and localizer of 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Rab-17\",\"id\":\"Q9H0T7\"},{\"label\":\"Ras-related protein Rab-18\",\"id\":\"Q9NP72\"},{\"label\":\"Ras-related protein Rab-19\",\"id\":\"A4D1S5\"},{\"label\":\"Ras-related protein Rab-1A\",\"id\":\"P62820\"},{\"label\":\"Ras-related protein Rab-1B\",\"id\":\"Q9H0U4\"},{\"label\":\"Ras-related protein Rab-20\",\"id\":\"Q9NX57\"},{\"label\":\"Ras-related protein Rab-21\",\"id\":\"Q9UL25\"},{\"label\":\"Ras-related protein Rab-22A\",\"id\":\"Q9UL26\"},{\"label\":\"Ras-related protein Rab-23\",\"id\":\"Q9ULC3\"},{\"label\":\"Ras-related protein Rab-24\",\"id\":\"Q969Q5\"},{\"label\":\"Ras-related protein Rab-25\",\"id\":\"P57735\"},{\"label\":\"Ras-related protein Rab-26\",\"id\":\"Q9ULW5\"},{\"label\":\"Ras-related protein Rab-27A\",\"id\":\"P51159\"},{\"label\":\"Ras-related protein Rab-27B\",\"id\":\"O00194\"},{\"label\":\"Ras-related protein Rab-2A\",\"id\":\"P61019\"},{\"label\":\"Ras-related protein Rab-2B\",\"id\":\"Q8WUD1\"},{\"label\":\"Ras-related protein Rab-30\",\"id\":\"Q15771\"},{\"label\":\"Ras-related protein Rab-31\",\"id\":\"Q13636\"},{\"label\":\"Ras-related protein Rab-32\",\"id\":\"Q13637\"},{\"label\":\"Ras-related protein Rab-33A\",\"id\":\"Q14088\"},{\"label\":\"Ras-related protein Rab-33B\",\"id\":\"Q9H082\"},{\"label\":\"Ras-related protein Rab-34\",\"id\":\"Q9BZG1\"},{\"label\":\"Ras-related protein Rab-35\",\"id\":\"Q15286\"},{\"label\":\"Ras-related protein Rab-36\",\"id\":\"O95755\"},{\"label\":\"Ras-related protein Rab-37\",\"id\":\"Q96AX2\"},{\"label\":\"Ras-related protein Rab-38\",\"id\":\"P57729\"},{\"label\":\"Ras-related protein Rab-39A\",\"id\":\"Q14964\"},{\"label\":\"Ras-related protein Rab-39B\",\"id\":\"Q96DA2\"},{\"label\":\"Ras-related protein Rab-3A\",\"id\":\"P20336\"},{\"label\":\"Ras-related protein Rab-3B\",\"id\":\"P20337\"},{\"label\":\"Ras-related protein Rab-3C\",\"id\":\"Q96E17\"},{\"label\":\"Ras-related protein Rab-3D\",\"id\":\"O95716\"},{\"label\":\"Ras-related protein Rab-40A\",\"id\":\"Q8WXH6\"},{\"label\":\"Ras-related protein Rab-40B\",\"id\":\"Q12829\"},{\"label\":\"Ras-related protein Rab-40C\",\"id\":\"Q96S21\"},{\"label\":\"Ras-related protein Rab-41\",\"id\":\"Q5JT25\"},{\"label\":\"Ras-related protein Rab-42\",\"id\":\"Q8N4Z0\"},{\"label\":\"Ras-related protein Rab-43\",\"id\":\"Q86YS6\"},{\"label\":\"Ras-related protein Rab-44\",\"id\":\"Q7Z6P3\"},{\"label\":\"Ras-related protein Rab-4A\",\"id\":\"P20338\"},{\"label\":\"Ras-related protein Rab-4B\",\"id\":\"P61018\"},{\"label\":\"Ras-related protein Rab-5A\",\"id\":\"P20339\"},{\"label\":\"Ras-related protein Rab-5B\",\"id\":\"P61020\"},{\"label\":\"Ras-related protein Rab-5C\",\"id\":\"P51148\"},{\"label\":\"Ras-related protein Rab-6A\",\"id\":\"P20340\"},{\"label\":\"Ras-related protein Rab-6B\",\"id\":\"Q9NRW1\"},{\"label\":\"Ras-related protein Rab-7L1\",\"id\":\"O14966\"},{\"label\":\"Ras-related protein Rab-7a\",\"id\":\"P51149\"},{\"label\":\"Ras-related protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "COX reactions", "protein_name": "[{\"label\":\"Prostaglandin G/H synthase 1\",\"id\":\"P23219\"}]", "uniprot_id": "[\"P23219\"]", "gene_symbol": "[\"COX1\",\"PTGS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Neddylation", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 8\",\"id\":\"P62195\"},{\"label\":\"APC membrane recruitment protein 1\",\"id\":\"Q5JTC6\"},{\"label\":\"Ankyrin repeat and SOCS box protein 10\",\"id\":\"Q8WXI3\"},{\"label\":\"Ankyrin repeat and SOCS box protein 11\",\"id\":\"Q8WXH4\"},{\"label\":\"Ankyrin repeat and SOCS box protein 12\",\"id\":\"Q8WXK4\"},{\"label\":\"Ankyrin repeat and SOCS box protein 13\",\"id\":\"Q8WXK3\"},{\"label\":\"Ankyrin repeat and SOCS box protein 14\",\"id\":\"A6NK59\"},{\"label\":\"Ankyrin repeat and SOCS box protein 15\",\"id\":\"Q8WXK1\"},{\"label\":\"Ankyrin repeat and SOCS box protein 16\",\"id\":\"Q96NS5\"},{\"label\":\"Ankyrin repeat and SOCS box protein 17\",\"id\":\"Q8WXJ9\"},{\"label\":\"Ankyrin repeat and SOCS box protein 18\",\"id\":\"Q6ZVZ8\"},{\"label\":\"Ankyrin repeat and SOCS box protein 1\",\"id\":\"Q9Y576\"},{\"label\":\"Ankyrin repeat and SOCS box protein 2\",\"id\":\"Q96Q27\"},{\"label\":\"Ankyrin repeat and SOCS box protein 3\",\"id\":\"Q9Y575\"},{\"label\":\"Ankyrin repeat and SOCS box protein 4\",\"id\":\"Q9Y574\"},{\"label\":\"Ankyrin repeat and SOCS box protein 5\",\"id\":\"Q8WWX0\"},{\"label\":\"Ankyrin repeat and SOCS box protein 6\",\"id\":\"Q9NWX5\"},{\"label\":\"Ankyrin repeat and SOCS box protein 7\",\"id\":\"Q9H672\"},{\"label\":\"Ankyrin repeat and SOCS box protein 8\",\"id\":\"Q9H765\"},{\"label\":\"Ankyrin repeat and SOCS box protein 9\",\"id\":\"Q96DX5\"},{\"label\":\"Ankyrin repeat domain-containing protein 9\",\"id\":\"Q96BM1\"},{\"label\":\"BTB/POZ domain-containing protein 1\",\"id\":\"Q9H0C5\"},{\"label\":\"BTB/POZ domain-containing protein 6\",\"id\":\"Q96KE9\"},{\"label\":\"BTB/POZ domain-containing protein KCTD6\",\"id\":\"Q8NC69\"},{\"label\":\"BTB/POZ domain-containing protein KCTD7\",\"id\":\"Q96MP8\"},{\"label\":\"Baculoviral IAP repeat-containing protein 5\",\"id\":\"O15392\"},{\"label\":\"Breast cancer type 1 susceptibility protein\",\"id\":\"P38398\"},{\"label\":\"COMM domain-containing protein 10\",\"id\":\"Q9Y6G5\"},{\"label\":\"COMM domain-containing protein 1\",\"id\":\"Q8N668\"},{\"label\":\"COMM domain-containing protein 2\",\"id\":\"Q86X83\"},{\"label\":\"COMM domain-containing protein 3\",\"id\":\"Q9UBI1\"},{\"label\":\"COMM domain-containing protein 4\",\"id\":\"Q9H0A8\"},{\"label\":\"COMM domain-containing protein 5\",\"id\":\"Q9GZQ3\"},{\"label\":\"COMM domain-containing protein 6\",\"id\":\"Q7Z4G1\"},{\"label\":\"COMM domain-containing protein 7\",\"id\":\"Q86VX2\"},{\"label\":\"COMM domain-containing protein 8\",\"id\":\"Q9NX08\"},{\"label\":\"COMM domain-containing protein 9\",\"id\":\"Q9P000\"},{\"label\":\"COP9 signalosome complex subunit 1\",\"id\":\"Q13098\"},{\"label\":\"COP9 signalosome complex subunit 2\",\"id\":\"P61201\"},{\"label\":\"COP9 signalosome complex subunit 3\",\"id\":\"Q9UNS2\"},{\"label\":\"COP9 signalosome complex subunit 4\",\"id\":\"Q9BT78\"},{\"label\":\"COP9 signalosome complex subunit 5\",\"id\":\"Q92905\"},{\"label\":\"COP9 signalosome complex subunit 6\",\"id\":\"Q7L5N1\"},{\"label\":\"COP9 signalosome complex subunit 7a\",\"id\":\"Q9UBW8\"},{\"label\":\"COP9 signalosome complex subunit 7b\",\"id\":\"Q9H9Q2\"},{\"label\":\"COP9 signalosome complex subunit 8\",\"id\":\"Q99627\"},{\"label\":\"Coiled-coil domain-containing protein 22\",\"id\":\"O60826\"},{\"label\":\"Coiled-coil domain-containing protein 8\",\"id\":\"Q9H0W5\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"Cullin-2\",\"id\":\"Q13617\"},{\"label\":\"Cullin-3\",\"id\":\"Q13618\"},{\"label\":\"Cullin-4A\",\"id\":\"Q13619\"},{\"label\":\"Cullin-4B\",\"id\":\"Q13620\"},{\"label\":\"Cullin-5\",\"id\":\"Q93034\"},{\"label\":\"Cullin-7\",\"id\":\"Q14999\"},{\"label\":\"Cullin-9\",\"id\":\"Q8IWT3\"},{\"label\":\"Cullin-associated NEDD8-dissociated protein 1\",\"id\":\"Q86VP6\"},{\"label\":\"Cyclin-F\",\"id\":\"P41002\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cytokine-inducible SH2-containing protein\",\"id\":\"Q9NSE2\"},{\"label\":\"DCN1-like protein 1\",\"id\":\"Q96GG9\"},{\"label\":\"DCN1-like protein 2\",\"id\":\"Q6PH85\"},{\"label\":\"DCN1-like protein 3\",\"id\":\"Q8IWE4\"},{\"label\":\"DCN1-like protein 4\",\"id\":\"Q92564\"},{\"label\":\"DCN1-like protein 5\",\"id\":\"Q9BTE7\"},{\"label\":\"DDB1- and CUL4-associated factor 10\",\"id\":\"Q5QP82\"},{\"label\":\"DDB1- and CUL4-associated factor 11\",\"id\":\"Q8TEB1\"},{\"label\":\"DDB1- and CUL4-associated factor 13\",\"id\":\"Q9NV06\"},{\"label\":\"DDB1- and CUL4-associated factor 16\",\"id\":\"Q9NXF7\"},{\"label\":\"DDB1- and CUL4-associated factor 17\",\"id\":\"Q5H9S7\"},{\"label\":\"DDB1- and CUL4-associated factor 4\",\"id\":\"Q8WV16\"},{\"label\":\"DDB1- and CUL4-associated factor 5\",\"id\":\"Q96JK2\"},{\"label\":\"DDB1- and CUL4-associated factor 6\",\"id\":\"Q58WW2\"},{\"label\":\"DDB1- and CUL4-associated factor 7\",\"id\":\"P61962\"},{\"label\":\"DDB1- and CUL4-associated factor 8\",\"id\":\"Q5TAQ9\"},{\"label\":\"DET1- and DDB1-associated protein 1\",\"id\":\"Q9BW61\"},{\"label\":\"DNA damage-binding protein 1\",\"id\":\"Q16531\"},{\"label\":\"DNA damage-binding protein 2\",\"id\":\"Q92466\"},{\"label\":\"DNA excision repair protein ERCC-8\",\"id\":\"Q13216\"},{\"label\":\"Denticleless protein homolog\",\"id\":\"Q9NZJ0\"},{\"label\":\"Dipeptidyl peptidase 3\",\"id\":\"Q9NY33\"},{\"label\":\"E3 ubiquitin-protein ligase COP1\",\"id\":\"Q8NHY2\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"Elongin-B\",\"id\":\"Q15370\"},{\"label\":\"Elongin-C\",\"id\":\"Q15369\"},{\"label\":\"Endothelial PAS domain-containing protein 1\",\"id\":\"Q99814\"},{\"label\":\"F-box and leucine-rich protein 22\",\"id\":\"Q6P050\"},{\"label\":\"F-box and leucine-rich repeat protein 13\",\"id\":\"Q8NEE6\"},{\"label\":\"F-box only protein 10\",\"id\":\"Q9UK96\"},{\"label\":\"F-box only protein 11\",\"id\":\"Q86XK2\"},{\"label\":\"F-box only protein 15\",\"id\":\"Q8NCQ5\"},{\"label\":\"F-box only protein 17\",\"id\":\"Q96EF6\"},{\"label\":\"F-box only protein 21\",\"id\":\"O94952\"},{\"label\":\"F-box only protein 22\",\"id\":\"Q8NEZ5\"},{\"label\":\"F-box only protein 27\",\"id\":\"Q8NI29\"},{\"label\":\"F-box only protein 2\",\"id\":\"Q9UK22\"},{\"label\":\"F-box only protein 30\",\"id\":\"Q8TB52\"},{\"label\":\"F-box only protein 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\",\"TCEB1L\",\"TCEB2\",\"TIP120\",\"TIP120A\",\"TRAP2\",\"TRIP15\",\"TUBL4\",\"TULP4\",\"TUSP\",\"UBA3\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBC12\",\"UBC4\",\"UBC5A\",\"UBC5B\",\"UBC5C\",\"UBCEP1\",\"UBCEP2\",\"UBCH4\",\"UBCH5\",\"UBCH5A\",\"UBCH5B\",\"UBCH5C\",\"UBD\",\"UBE1C\",\"UBE2D1\",\"UBE2D2\",\"UBE2D3\",\"UBE2F\",\"UBE2M\",\"UBXD7\",\"UBXN7\",\"UCHL3\",\"UFD1\",\"UFD1L\",\"VACM1\",\"VCIA1\",\"VCP\",\"VHL\",\"VIT1\",\"WAF1\",\"WDR21\",\"WDR21A\",\"WDR22\",\"WDR23\",\"WDR32\",\"WDR42A\",\"WDR5\",\"WDR68\",\"WDSOF1\",\"WDTC1\",\"WSB1\",\"WSB2\",\"WTX\",\"X\",\"XAP1\",\"Y\",\"Z\",\"ZBTB16\",\"ZNF145\",\"x\"]", 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2\",\"id\":\"Q9NY97\"},{\"label\":\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3\",\"id\":\"Q9Y2A9\"},{\"label\":\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4\",\"id\":\"Q9C0J1\"},{\"label\":\"Nucleotide sugar transporter SLC35D2\",\"id\":\"Q76EJ3\"},{\"label\":\"Osteomodulin\",\"id\":\"Q99983\"},{\"label\":\"Prolargin\",\"id\":\"P51888\"},{\"label\":\"Type 2 lactosamine alpha-2,3-sialyltransferase\",\"id\":\"Q9Y274\"},{\"label\":\"UDP-GlcNAc\",\"id\":\"betaGal beta-1,3-N-acetylglucosaminyltransferase 7:Q8NFL0\"}]", "uniprot_id": "[\"O43286\",\"O43505\",\"O43916\",\"O60512\",\"O60513\",\"O60909\",\"O60938\",\"P15291\",\"P16112\",\"P20774\",\"P51884\",\"P51888\",\"Q06828\",\"Q11201\",\"Q11203\",\"Q11206\",\"Q16842\",\"Q76EJ3\",\"Q8NFL0\",\"Q99983\",\"Q9C0J1\",\"Q9GZS9\",\"Q9GZX3\",\"Q9NY97\",\"Q9UBX8\",\"Q9Y274\",\"Q9Y2A9\",\"Q9Y4C5\"]", "gene_symbol": "[\"ACAN\",\"AGC1\",\"B3GALT7\",\"B3GALT8\",\"B3GNT1\",\"B3GNT2\",\"B3GNT3\",\"B3GNT4\",\"B3GNT6\",\"B3GNT7\",\"B4GALT1\",\"B4GALT2\",\"B4GALT3\",\"B4GALT4\",\"B4GALT5\",\"B4GALT6\",\"B4GAT1\",\"CGS23\",\"CHST1\",\"CHST2\",\"CHST5\",\"CHST6\",\"CSPG1\",\"FM\",\"FMOD\",\"GGTB2\",\"GN6ST\",\"HFRC\",\"KERA\",\"LDC\",\"LUM\",\"MSK16\",\"NANTA3\",\"OGN\",\"OIF\",\"OMD\",\"PRELP\",\"SIAT10\",\"SIAT4\",\"SIAT4A\",\"SIAT4B\",\"SIAT4C\",\"SIAT6\",\"SLC35D2\",\"SLRR2A\",\"SLRR2B\",\"SLRR2C\",\"SLRR2D\",\"SLRR2E\",\"SLRR3A\",\"ST3GAL1\",\"ST3GAL2\",\"ST3GAL3\",\"ST3GAL4\",\"ST3GAL6\",\"STZ\",\"TMEM3\",\"UGTREL8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IRF3 mediated activation of type 1 IFN", "protein_name": "[{\"label\":\"E3 ubiquitin-protein ligase DTX4\",\"id\":\"Q9Y2E6\"},{\"label\":\"Interferon regulatory factor 3\",\"id\":\"Q14653\"},{\"label\":\"NACHT, LRR and PYD domains-containing protein 4\",\"id\":\"Q96MN2\"},{\"label\":\"Serine/threonine-protein kinase TBK1\",\"id\":\"Q9UHD2\"},{\"label\":\"Z-DNA-binding protein 1\",\"id\":\"Q9H171\"}]", "uniprot_id": "[\"Q14653\",\"Q96MN2\",\"Q9H171\",\"Q9UHD2\",\"Q9Y2E6\"]", "gene_symbol": "[\"C20orf183\",\"DLM1\",\"DTX4\",\"IRF3\",\"KIAA0937\",\"NAK\",\"NALP4\",\"NLRP4\",\"PAN2\",\"PYPAF4\",\"RNF155\",\"RNH2\",\"TBK1\",\"ZBP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria", "protein_name": "[{\"label\":\"Inactive sodium-dependent neutral amino acid transporter B(0)AT3\",\"id\":\"Q96N87\"}]", "uniprot_id": "[\"Q96N87\"]", "gene_symbol": "[\"B0AT3\",\"SLC6A18\",\"XTRP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NOSIP mediated eNOS trafficking", "protein_name": "[{\"label\":\"Nitric oxide synthase 3\",\"id\":\"P29474\"},{\"label\":\"Nitric oxide synthase-interacting protein\",\"id\":\"Q9Y314\"}]", "uniprot_id": "[\"P29474\",\"Q9Y314\"]", "gene_symbol": "[\"NOS3\",\"NOSIP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of D-series resolvins", "protein_name": "[{\"label\":\"15-hydroxyprostaglandin dehydrogenase [NAD(+)]\",\"id\":\"P15428\"},{\"label\":\"Leukotriene A-4 hydrolase\",\"id\":\"P09960\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"}]", "uniprot_id": "[\"P09917\",\"P09960\",\"P15428\"]", "gene_symbol": "[\"ALOX5\",\"HPGD\",\"LOG5\",\"LTA4\",\"LTA4H\",\"PGDH1\",\"SDR36C1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Noncanonical activation of NOTCH3", "protein_name": "[{\"label\":\"Gamma-secretase subunit APH-1A\",\"id\":\"Q96BI3\"},{\"label\":\"Gamma-secretase subunit APH-1B\",\"id\":\"Q8WW43\"},{\"label\":\"Gamma-secretase subunit PEN-2\",\"id\":\"Q9NZ42\"},{\"label\":\"Neurogenic locus notch homolog protein 3\",\"id\":\"Q9UM47\"},{\"label\":\"Nicastrin\",\"id\":\"Q92542\"},{\"label\":\"Presenilin-1\",\"id\":\"P49768\"},{\"label\":\"Presenilin-2\",\"id\":\"P49810\"},{\"label\":\"Y-box-binding protein 1\",\"id\":\"P67809\"}]", "uniprot_id": "[\"P49768\",\"P49810\",\"P67809\",\"Q8WW43\",\"Q92542\",\"Q96BI3\",\"Q9NZ42\",\"Q9UM47\"]", "gene_symbol": "[\"AD3\",\"AD4\",\"APH1A\",\"APH1B\",\"KIAA0253\",\"NCSTN\",\"NOTCH3\",\"NSEP1\",\"PEN2\",\"PS1\",\"PS2\",\"PSEN1\",\"PSEN2\",\"PSENEN\",\"PSF\",\"PSFL\",\"PSNL1\",\"PSNL2\",\"STM2\",\"YB1\",\"YBX1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "IRS activation", "protein_name": "[{\"label\":\"Growth factor receptor-bound protein 10\",\"id\":\"Q13322\"},{\"label\":\"Insulin receptor substrate 1\",\"id\":\"P35568\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Insulin receptor\",\"id\":\"P06213\"},{\"label\":\"Insulin\",\"id\":\"P01308\"}]", "uniprot_id": "[\"P01308\",\"P06213\",\"P35568\",\"Q13322\",\"Q9Y4H2\"]", "gene_symbol": "[\"GRB10\",\"GRBIR\",\"INS\",\"INSR\",\"IRS1\",\"IRS2\",\"KIAA0207\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Prevention of phagosomal-lysosomal fusion", "protein_name": "[{\"label\":\"Coronin-1A\",\"id\":\"P31146\"},{\"label\":\"Dihydrolipoyl dehydrogenase\",\"id\":\"P9WHH9\"},{\"label\":\"ESAT-6-like protein EsxG\",\"id\":\"O53692\"},{\"label\":\"ESAT-6-like protein EsxH\",\"id\":\"P9WNK3\"},{\"label\":\"Hepatocyte growth factor-regulated tyrosine kinase substrate\",\"id\":\"O14964\"},{\"label\":\"Lipoarabinomannan carrier protein LprG\",\"id\":\"P9WK45\"},{\"label\":\"Low molecular weight protein-tyrosine phosphatase A\",\"id\":\"P9WIA1\"},{\"label\":\"Nucleoside diphosphate kinase\",\"id\":\"P9WJH7\"},{\"label\":\"Phosphatidylinositol-3-phosphatase\",\"id\":\"O53361\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein translocase subunit SecA 2\",\"id\":\"P9WGP3\"},{\"label\":\"Ras-related protein Rab-5A\",\"id\":\"P20339\"},{\"label\":\"Ras-related protein Rab-7a\",\"id\":\"P51149\"},{\"label\":\"Triacylglyceride transporter Rv1410c\",\"id\":\"P9WJY3\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"Vacuolar protein sorting-associated protein 33B\",\"id\":\"Q9H267\"}]", "uniprot_id": "[\"O14964\",\"O53361\",\"O53692\",\"P0CG47\",\"P0CG48\",\"P20339\",\"P31146\",\"P51149\",\"P62979\",\"P62987\",\"P9WGP3\",\"P9WHH9\",\"P9WIA1\",\"P9WJH7\",\"P9WJY3\",\"P9WK45\",\"P9WNK3\",\"Q9H267\"]", "gene_symbol": "[\"CORO1\",\"CORO1A\",\"HGS\",\"HRS\",\"RAB5\",\"RAB5A\",\"RAB7\",\"RAB7A\",\"RPS27A\",\"Rv1410c\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"VPS33B\",\"cfp7\",\"esxG\",\"esxH\",\"lpd\",\"lpdC\",\"lpp-27\",\"lprG\",\"mptpA\",\"ndk\",\"ndkA\",\"ptpA\",\"sapM\",\"secA2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)", "protein_name": "[{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase 4\",\"id\":\"P11802\"},{\"label\":\"Cyclin-dependent kinase 6\",\"id\":\"Q00534\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1\",\"id\":\"P38936\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1B\",\"id\":\"P46527\"},{\"label\":\"Cyclin-dependent kinase inhibitor 1C\",\"id\":\"P49918\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"G1/S-specific cyclin-D2\",\"id\":\"P30279\"},{\"label\":\"G1/S-specific cyclin-D3\",\"id\":\"P30281\"},{\"label\":\"G1/S-specific cyclin-E1\",\"id\":\"P24864\"},{\"label\":\"G1/S-specific cyclin-E2\",\"id\":\"O96020\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"},{\"label\":\"Transcription factor E2F2\",\"id\":\"Q14209\"},{\"label\":\"Transcription factor E2F3\",\"id\":\"O00716\"}]", "uniprot_id": "[\"O00716\",\"O96020\",\"P06400\",\"P11802\",\"P24385\",\"P24864\",\"P24941\",\"P30279\",\"P30281\",\"P38936\",\"P46527\",\"P49918\",\"Q00534\",\"Q01094\",\"Q14186\",\"Q14188\",\"Q14209\"]", "gene_symbol": "[\"BCL1\",\"CAP20\",\"CCND1\",\"CCND2\",\"CCND3\",\"CCNE\",\"CCNE1\",\"CCNE2\",\"CDK2\",\"CDK4\",\"CDK6\",\"CDKN1\",\"CDKN1A\",\"CDKN1B\",\"CDKN1C\",\"CDKN2\",\"CDKN6\",\"CIP1\",\"DP1\",\"DP2\",\"E2F1\",\"E2F2\",\"E2F3\",\"KIAA0075\",\"KIP1\",\"KIP2\",\"MDA6\",\"PIC1\",\"PRAD1\",\"RB1\",\"RBBP3\",\"SDI1\",\"TFDP1\",\"TFDP2\",\"WAF1\",\"p27\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Downstream signaling of activated FGFR1", "protein_name": "[{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 22\",\"id\":\"Q9HCT0\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 3\",\"id\":\"P11487\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 6\",\"id\":\"P10767\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Leucine-rich repeat transmembrane protein FLRT1\",\"id\":\"Q9NZU1\"},{\"label\":\"Leucine-rich repeat transmembrane protein FLRT2\",\"id\":\"O43155\"},{\"label\":\"Leucine-rich repeat transmembrane protein FLRT3\",\"id\":\"Q9NZU0\"}]", "uniprot_id": "[\"O15520\",\"O43155\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11487\",\"P31371\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\",\"Q9NZU0\",\"Q9NZU1\"]", "gene_symbol": "[\"FGF1\",\"FGF10\",\"FGF2\",\"FGF20\",\"FGF22\",\"FGF23\",\"FGF3\",\"FGF4\",\"FGF6\",\"FGF9\",\"FGFA\",\"FGFB\",\"FLRT1\",\"FLRT2\",\"FLRT3\",\"HST\",\"HST2\",\"HSTF1\",\"HSTF2\",\"HYPF\",\"INT2\",\"KIAA0405\",\"KIAA1469\",\"KS3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "COPII-mediated vesicle transport", "protein_name": "[{\"label\":\"Alpha-1-antitrypsin\",\"id\":\"P01009\"},{\"label\":\"Alpha-soluble NSF attachment protein\",\"id\":\"P54920\"},{\"label\":\"Amphiregulin\",\"id\":\"P15514\"},{\"label\":\"BET1 homolog\",\"id\":\"O15155\"},{\"label\":\"Beta-soluble NSF attachment protein\",\"id\":\"Q9H115\"},{\"label\":\"CD59 glycoprotein\",\"id\":\"P13987\"},{\"label\":\"Casein kinase I isoform delta\",\"id\":\"P48730\"},{\"label\":\"Cathepsin Z\",\"id\":\"Q9UBR2\"},{\"label\":\"Coagulation factor V\",\"id\":\"P12259\"},{\"label\":\"Coagulation factor VIII\",\"id\":\"P00451\"},{\"label\":\"Collagen alpha-1(VII) chain\",\"id\":\"Q02388\"},{\"label\":\"Dipeptidyl peptidase 1\",\"id\":\"P53634\"},{\"label\":\"Folate receptor alpha\",\"id\":\"P15328\"},{\"label\":\"Gamma-soluble NSF attachment protein\",\"id\":\"Q99747\"},{\"label\":\"General vesicular transport factor p115\",\"id\":\"O60763\"},{\"label\":\"Glutamate receptor 1\",\"id\":\"P42261\"},{\"label\":\"Golgi SNAP receptor complex member 2\",\"id\":\"O14653\"},{\"label\":\"Golgi reassembly-stacking protein 1\",\"id\":\"Q9BQQ3\"},{\"label\":\"Golgin subfamily A member 2\",\"id\":\"Q08379\"},{\"label\":\"Guanine nucleotide-exchange factor SEC12\",\"id\":\"Q9HCU5\"},{\"label\":\"Multiple coagulation factor deficiency protein 2\",\"id\":\"Q8NI22\"},{\"label\":\"Protein ERGIC-53-like\",\"id\":\"Q9HAT1\"},{\"label\":\"Protein ERGIC-53\",\"id\":\"P49257\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Protein TFG\",\"id\":\"Q92734\"},{\"label\":\"Protein cornichon homolog 1\",\"id\":\"O95406\"},{\"label\":\"Protein cornichon homolog 2\",\"id\":\"Q6PI25\"},{\"label\":\"Protein cornichon homolog 3\",\"id\":\"Q8TBE1\"},{\"label\":\"Protein transport protein Sec16A\",\"id\":\"O15027\"},{\"label\":\"Protein transport protein Sec16B\",\"id\":\"Q96JE7\"},{\"label\":\"Protein transport protein Sec23A\",\"id\":\"Q15436\"},{\"label\":\"Protein transport protein Sec24A\",\"id\":\"O95486\"},{\"label\":\"Protein transport protein Sec24B\",\"id\":\"O95487\"},{\"label\":\"Protein transport protein Sec24C\",\"id\":\"P53992\"},{\"label\":\"Protein transport protein Sec24D\",\"id\":\"O94855\"},{\"label\":\"Protein transport protein Sec31A\",\"id\":\"O94979\"},{\"label\":\"Protein transport protein Sec31B\",\"id\":\"Q9NQW1\"},{\"label\":\"Protransforming growth factor alpha\",\"id\":\"P01135\"},{\"label\":\"Ras-related protein Rab-1A\",\"id\":\"P62820\"},{\"label\":\"Ras-related protein Rab-1B\",\"id\":\"Q9H0U4\"},{\"label\":\"SEC23-interacting protein\",\"id\":\"Q9Y6Y8\"},{\"label\":\"Sec1 family domain-containing protein 1\",\"id\":\"Q8WVM8\"},{\"label\":\"Serine/threonine-protein phosphatase 6 catalytic subunit\",\"id\":\"O00743\"},{\"label\":\"Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A\",\"id\":\"O15084\"},{\"label\":\"Serine/threonine-protein phosphatase 6 regulatory subunit 1\",\"id\":\"Q9UPN7\"},{\"label\":\"Serine/threonine-protein phosphatase 6 regulatory subunit 3\",\"id\":\"Q5H9R7\"},{\"label\":\"Small COPII coat GTPase SAR1B\",\"id\":\"Q9Y6B6\"},{\"label\":\"Synaptobrevin homolog YKT6\",\"id\":\"O15498\"},{\"label\":\"Syntaxin-17\",\"id\":\"P56962\"},{\"label\":\"Syntaxin-5\",\"id\":\"Q13190\"},{\"label\":\"TBC1 domain family member 20\",\"id\":\"Q96BZ9\"},{\"label\":\"Trafficking protein particle complex subunit 10\",\"id\":\"P48553\"},{\"label\":\"Trafficking protein particle complex subunit 1\",\"id\":\"Q9Y5R8\"},{\"label\":\"Trafficking protein particle complex subunit 2-like protein\",\"id\":\"Q9UL33\"},{\"label\":\"Trafficking protein particle complex subunit 2\",\"id\":\"P0DI81\"},{\"label\":\"Trafficking protein particle complex subunit 3\",\"id\":\"O43617\"},{\"label\":\"Trafficking protein particle complex subunit 4\",\"id\":\"Q9Y296\"},{\"label\":\"Trafficking protein particle complex subunit 5\",\"id\":\"Q8IUR0\"},{\"label\":\"Trafficking protein particle complex subunit 6A\",\"id\":\"O75865\"},{\"label\":\"Trafficking protein particle complex subunit 6B\",\"id\":\"Q86SZ2\"},{\"label\":\"Trafficking protein particle complex subunit 9\",\"id\":\"Q96Q05\"},{\"label\":\"Transmembrane emp24 domain-containing protein 10\",\"id\":\"P49755\"},{\"label\":\"Transmembrane emp24 domain-containing protein 2\",\"id\":\"Q15363\"},{\"label\":\"VIP36-like protein\",\"id\":\"Q9H0V9\"},{\"label\":\"Vesicle-fusing ATPase\",\"id\":\"P46459\"},{\"label\":\"Vesicle-trafficking protein SEC22a\",\"id\":\"Q96IW7\"},{\"label\":\"Vesicle-trafficking protein SEC22b\",\"id\":\"O75396\"},{\"label\":\"Vesicle-trafficking protein SEC22c\",\"id\":\"Q9BRL7\"},{\"label\":\"Vesicular integral-membrane protein VIP36\",\"id\":\"Q12907\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Translation of Replicase and Assembly of the Replication Transcription Complex", "protein_name": "[{\"label\":\"Beclin-1\",\"id\":\"Q14457\"},{\"label\":\"Charged multivesicular body protein 2a\",\"id\":\"O43633\"},{\"label\":\"Charged multivesicular body protein 2b\",\"id\":\"Q9UQN3\"},{\"label\":\"Charged multivesicular body protein 3\",\"id\":\"Q9Y3E7\"},{\"label\":\"Charged multivesicular body protein 4a\",\"id\":\"Q9BY43\"},{\"label\":\"Charged multivesicular body protein 4b\",\"id\":\"Q9H444\"},{\"label\":\"Charged multivesicular body protein 4c\",\"id\":\"Q96CF2\"},{\"label\":\"Charged multivesicular body protein 6\",\"id\":\"Q96FZ7\"},{\"label\":\"Charged multivesicular body protein 7\",\"id\":\"Q8WUX9\"},{\"label\":\"Microtubule-associated proteins 1A/1B light chain 3B\",\"id\":\"Q9GZQ8\"},{\"label\":\"ORF8b protein\",\"id\":\"Q80H93\"},{\"label\":\"ORF9b protein\",\"id\":\"P59636\"},{\"label\":\"Phosphatidylinositol 3-kinase catalytic 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"[\"DCC\",\"DSCAM\",\"DSCAM2\",\"DSCAML1\",\"IGDCC1\",\"KIAA1132\",\"NTN1\",\"NTN1L\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Succinyl-CoA Biosynthesis", "protein_name": "[{\"label\":\"2-oxoglutarate dehydrogenase complex component E1\",\"id\":\"Q02218\"},{\"label\":\"Alpha-ketoglutarate dehydrogenase component 4\",\"id\":\"P82909\"},{\"label\":\"Dihydrolipoyl dehydrogenase, mitochondrial\",\"id\":\"P09622\"},{\"label\":\"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial\",\"id\":\"P36957\"}]", "uniprot_id": "[\"P09622\",\"P36957\",\"P82909\",\"Q02218\"]", "gene_symbol": "[\"DLD\",\"DLST\",\"DLTS\",\"GCSL\",\"KGD4\",\"LAD\",\"MRPS36\",\"OGDH\",\"PHE3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "GDP-fucose biosynthesis", "protein_name": "[{\"label\":\"Fucose mutarotase\",\"id\":\"A2VDF0\"},{\"label\":\"Fucose-1-phosphate guanylyltransferase\",\"id\":\"O14772\"},{\"label\":\"GDP-L-fucose synthase\",\"id\":\"Q13630\"},{\"label\":\"GDP-fucose transporter 1\",\"id\":\"Q96A29\"},{\"label\":\"GDP-mannose 4,6 dehydratase\",\"id\":\"O60547\"},{\"label\":\"L-fucose kinase\",\"id\":\"Q8N0W3\"}]", "uniprot_id": "[\"A2VDF0\",\"O14772\",\"O60547\",\"Q13630\",\"Q8N0W3\",\"Q96A29\"]", "gene_symbol": "[\"C10orf125\",\"FCSK\",\"FPGT\",\"FUCT1\",\"FUK\",\"FUOM\",\"GFPP\",\"GFUS\",\"GMDS\",\"SDR4E1\",\"SLC35C1\",\"TSTA3\"]", "gtc_id": "[\"G85196CF\",\"G96881BQ\"]" }, { "pathway_label": "Signaling by juxtamembrane domain KIT mutants", "protein_name": "[{\"label\":\"Mast/stem cell growth factor receptor Kit\",\"id\":\"P10721\"}]", "uniprot_id": "[\"P10721\"]", "gene_symbol": "[\"KIT\",\"SCFR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-2 family signaling", "protein_name": "[{\"label\":\"Galectin-9\",\"id\":\"O00182\"},{\"label\":\"Hepatitis A virus cellular receptor 2\",\"id\":\"Q8TDQ0\"}]", "uniprot_id": "[\"O00182\",\"Q8TDQ0\"]", "gene_symbol": "[\"HAVCR2\",\"LGALS9\",\"TIM3\",\"TIMD3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Assembly of the pre-replicative complex", "protein_name": "[{\"label\":\"26S proteasome complex subunit SEM1\",\"id\":\"P60896\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 11\",\"id\":\"O00231\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 12\",\"id\":\"O00232\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory 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channel protein type 4 subunit alpha\",\"id\":\"P35499\"},{\"label\":\"Sodium channel protein type 5 subunit alpha\",\"id\":\"Q14524\"},{\"label\":\"Sodium channel protein type 7 subunit alpha\",\"id\":\"Q01118\"},{\"label\":\"Sodium channel protein type 8 subunit alpha\",\"id\":\"Q9UQD0\"},{\"label\":\"Sodium channel protein type 9 subunit alpha\",\"id\":\"Q15858\"},{\"label\":\"Sodium channel regulatory subunit beta-1\",\"id\":\"Q07699\"},{\"label\":\"Sodium channel regulatory subunit beta-2\",\"id\":\"O60939\"},{\"label\":\"Sodium channel regulatory subunit beta-3\",\"id\":\"Q9NY72\"},{\"label\":\"Sodium channel subunit beta-4\",\"id\":\"Q8IWT1\"},{\"label\":\"Spectrin alpha chain, erythrocytic 1\",\"id\":\"P02549\"},{\"label\":\"Spectrin alpha chain, non-erythrocytic 1\",\"id\":\"Q13813\"},{\"label\":\"Spectrin beta chain, erythrocytic\",\"id\":\"P11277\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 1\",\"id\":\"Q01082\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 2\",\"id\":\"O15020\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 4\",\"id\":\"Q9H254\"},{\"label\":\"Spectrin beta chain, non-erythrocytic 5\",\"id\":\"Q9NRC6\"}]", "uniprot_id": "[\"O15020\",\"O43525\",\"O43526\",\"O60939\",\"O94856\",\"P02549\",\"P11277\",\"P16157\",\"P32004\",\"P35498\",\"P35499\",\"Q01082\",\"Q01118\",\"Q01484\",\"Q07699\",\"Q12955\",\"Q13813\",\"Q14524\",\"Q15858\",\"Q8IWT1\",\"Q92823\",\"Q99250\",\"Q9H254\",\"Q9NRC6\",\"Q9NY46\",\"Q9NY72\",\"Q9UI33\",\"Q9UQD0\",\"Q9Y5Y9\"]", "gene_symbol": 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type-2\",\"id\":\"Q99714\"},{\"label\":\"3-hydroxyisobutyrate dehydrogenase, mitochondrial\",\"id\":\"P31937\"},{\"label\":\"3-hydroxyisobutyryl-CoA hydrolase, mitochondrial\",\"id\":\"Q6NVY1\"},{\"label\":\"Acetyl-CoA acetyltransferase, mitochondrial\",\"id\":\"P24752\"},{\"label\":\"Branched-chain alpha-ketoacid dehydrogenase kinase\",\"id\":\"O14874\"},{\"label\":\"Branched-chain-amino-acid aminotransferase, cytosolic\",\"id\":\"P54687\"},{\"label\":\"Branched-chain-amino-acid aminotransferase, mitochondrial\",\"id\":\"O15382\"},{\"label\":\"Dihydrolipoyl dehydrogenase, mitochondrial\",\"id\":\"P09622\"},{\"label\":\"Enoyl-CoA hydratase, mitochondrial\",\"id\":\"P30084\"},{\"label\":\"Isobutyryl-CoA dehydrogenase, mitochondrial\",\"id\":\"Q9UKU7\"},{\"label\":\"Isovaleryl-CoA dehydrogenase, mitochondrial\",\"id\":\"P26440\"},{\"label\":\"Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial\",\"id\":\"P11182\"},{\"label\":\"Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial\",\"id\":\"Q9HCC0\"},{\"label\":\"Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial\",\"id\":\"Q96RQ3\"},{\"label\":\"Methylglutaconyl-CoA hydratase, mitochondrial\",\"id\":\"Q13825\"},{\"label\":\"Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial\",\"id\":\"Q02252\"},{\"label\":\"Protein phosphatase Mn(2+)-dependent 1K\",\"id\":\"Q8N3J5\"},{\"label\":\"Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P45954\"},{\"label\":\"Solute carrier family 25 member 44\",\"id\":\"Q96H78\"}]", "uniprot_id": "[\"O14874\",\"O15382\",\"P09622\",\"P11182\",\"P12694\",\"P21953\",\"P24752\",\"P26440\",\"P30084\",\"P31937\",\"P45954\",\"P54687\",\"Q02252\",\"Q13825\",\"Q6NVY1\",\"Q8N3J5\",\"Q96H78\",\"Q96RQ3\",\"Q99714\",\"Q9HCC0\",\"Q9UKU7\"]", "gene_symbol": 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chain\",\"id\":\"P02679\"},{\"label\":\"Fibronectin\",\"id\":\"P02751\"},{\"label\":\"Focal adhesion kinase 1\",\"id\":\"Q05397\"},{\"label\":\"Integrin alpha-IIb\",\"id\":\"P08514\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Proto-oncogene tyrosine-protein kinase Src\",\"id\":\"P12931\"},{\"label\":\"Ras-related protein Rap-1A\",\"id\":\"P62834\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"},{\"label\":\"Talin-1\",\"id\":\"Q9Y490\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"P02671\",\"P02675\",\"P02679\",\"P02751\",\"P04275\",\"P05106\",\"P08514\",\"P12931\",\"P46108\",\"P56945\",\"P61224\",\"P62834\",\"Q05397\",\"Q7Z5R6\",\"Q9Y490\"]", "gene_symbol": 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3\",\"id\":\"P35916\"}]", "uniprot_id": "[\"O43915\",\"P15692\",\"P17948\",\"P35916\",\"P35968\",\"P49763\",\"P49765\",\"P49767\"]", "gene_symbol": "[\"FIGF\",\"FLK1\",\"FLT\",\"FLT1\",\"FLT4\",\"FRT\",\"KDR\",\"PGF\",\"PGFL\",\"PLGF\",\"VEGF\",\"VEGFA\",\"VEGFB\",\"VEGFC\",\"VEGFD\",\"VEGFR1\",\"VEGFR2\",\"VEGFR3\",\"VRF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "activated TAK1 mediates p38 MAPK activation", "protein_name": "[{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 3\",\"id\":\"P46734\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 6\",\"id\":\"P52564\"},{\"label\":\"Interleukin-1 receptor-associated kinase 1\",\"id\":\"P51617\"},{\"label\":\"Interleukin-1 receptor-associated kinase-like 2\",\"id\":\"O43187\"},{\"label\":\"MAP kinase-activated protein kinase 2\",\"id\":\"P49137\"},{\"label\":\"MAP kinase-activated protein kinase 3\",\"id\":\"Q16644\"},{\"label\":\"Mitogen-activated protein kinase 11\",\"id\":\"Q15759\"},{\"label\":\"Mitogen-activated protein kinase 14\",\"id\":\"Q16539\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 7\",\"id\":\"O43318\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"Nucleotide-binding oligomerization domain-containing protein 1\",\"id\":\"Q9Y239\"},{\"label\":\"Nucleotide-binding oligomerization domain-containing protein 2\",\"id\":\"Q9HC29\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 2\",\"id\":\"O43353\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 1\",\"id\":\"Q15750\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2\",\"id\":\"Q9NYJ8\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 3\",\"id\":\"Q8N5C8\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 N\",\"id\":\"P61088\"},{\"label\":\"Ubiquitin-conjugating enzyme E2 variant 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gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform\",\"id\":\"P48736\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 5\",\"id\":\"Q8WYR1\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 6\",\"id\":\"Q5UE93\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"}]", "uniprot_id": 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uL10\",\"id\":\"P05388\"},{\"label\":\"Macrophage migration inhibitory factor\",\"id\":\"P14174\"},{\"label\":\"Moesin\",\"id\":\"P26038\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"Phosphatidylinositol transfer protein alpha isoform\",\"id\":\"Q00169\"},{\"label\":\"Plasminogen activator inhibitor 2\",\"id\":\"P05120\"},{\"label\":\"Plastin-2\",\"id\":\"P13796\"},{\"label\":\"Programmed cell death protein 4\",\"id\":\"Q53EL6\"},{\"label\":\"Proteasome activator complex subunit 2\",\"id\":\"Q9UL46\"},{\"label\":\"Ras-related protein Ral-A\",\"id\":\"P11233\"},{\"label\":\"Ras-related protein Rap-1b\",\"id\":\"P61224\"},{\"label\":\"S-methyl-5'-thioadenosine phosphorylase\",\"id\":\"Q13126\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Signal transducer and activator of transcription 4\",\"id\":\"Q14765\"},{\"label\":\"Stress-70 protein, mitochondrial\",\"id\":\"P38646\"},{\"label\":\"Superoxide dismutase [Cu-Zn]\",\"id\":\"P00441\"},{\"label\":\"Superoxide dismutase [Mn], mitochondrial\",\"id\":\"P04179\"},{\"label\":\"T-complex protein 1 subunit alpha\",\"id\":\"P17987\"},{\"label\":\"Transaldolase\",\"id\":\"P37837\"},{\"label\":\"U2 small nuclear ribonucleoprotein A'\",\"id\":\"P09661\"}]", "uniprot_id": "[\"O00170\",\"O14979\",\"P00441\",\"P00915\",\"P01579\",\"P04179\",\"P05120\",\"P05388\",\"P07355\",\"P09210\",\"P09661\",\"P11233\",\"P13796\",\"P14174\",\"P17987\",\"P20700\",\"P22301\",\"P22626\",\"P23528\",\"P26038\",\"P37837\",\"P38646\",\"P52597\",\"P52907\",\"P60953\",\"P61224\",\"P62937\",\"P78417\",\"P84077\",\"Q00169\",\"Q13126\",\"Q13177\",\"Q14765\",\"Q53EL6\",\"Q99439\",\"Q9H3K6\",\"Q9UL46\"]", "gene_symbol": 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"[\"ACO1\",\"IDH1\",\"IREB1\",\"PICD\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective visual phototransduction due to ABCA4 loss of function", "protein_name": "[{\"label\":\"Retinal-specific phospholipid-transporting ATPase ABCA4\",\"id\":\"P78363\"}]", "uniprot_id": "[\"P78363\"]", "gene_symbol": "[\"ABCA4\",\"ABCR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant", "protein_name": "[{\"label\":\"Delta-like protein 1\",\"id\":\"O00548\"},{\"label\":\"Delta-like protein 4\",\"id\":\"Q9NR61\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 10\",\"id\":\"O14672\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 17\",\"id\":\"P78536\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Protein jagged-2\",\"id\":\"Q9Y219\"}]", "uniprot_id": 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1\",\"id\":\"O00548\"},{\"label\":\"Delta-like protein 4\",\"id\":\"Q9NR61\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 10\",\"id\":\"O14672\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 17\",\"id\":\"P78536\"},{\"label\":\"E3 ubiquitin-protein ligase MIB1\",\"id\":\"Q86YT6\"},{\"label\":\"E3 ubiquitin-protein ligase MIB2\",\"id\":\"Q96AX9\"},{\"label\":\"E3 ubiquitin-protein ligase NEURL1\",\"id\":\"O76050\"},{\"label\":\"E3 ubiquitin-protein ligase NEURL1B\",\"id\":\"A8MQ27\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Protein jagged-2\",\"id\":\"Q9Y219\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"A8MQ27\",\"O00548\",\"O14672\",\"O76050\",\"P0CG47\",\"P0CG48\",\"P46531\",\"P62979\",\"P62987\",\"P78504\",\"P78536\",\"Q86YT6\",\"Q96AX9\",\"Q9NR61\",\"Q9Y219\"]", "gene_symbol": "[\"ADAM10\",\"ADAM17\",\"CSVP\",\"DIP1\",\"DLL1\",\"DLL4\",\"JAG1\",\"JAG2\",\"JAGL1\",\"KIAA1323\",\"KUZ\",\"MADM\",\"MIB1\",\"MIB2\",\"NEURL\",\"NEURL1\",\"NEURL1A\",\"NEURL1B\",\"NEURL3\",\"NOTCH1\",\"RNF67\",\"RPS27A\",\"SKD\",\"TACE\",\"TAN1\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"ZZANK1\",\"ZZANK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Peptide hormone biosynthesis", "protein_name": "[{\"label\":\"Neuroendocrine convertase 1\",\"id\":\"P29120\"},{\"label\":\"Pro-opiomelanocortin\",\"id\":\"P01189\"}]", "uniprot_id": "[\"P01189\",\"P29120\"]", "gene_symbol": "[\"NEC1\",\"PCSK1\",\"POMC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "G beta:gamma signalling through PLC beta", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1\",\"id\":\"Q9NQ66\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2\",\"id\":\"Q00722\"},{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3\",\"id\":\"Q01970\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10\",\"id\":\"P50151\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11\",\"id\":\"P61952\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12\",\"id\":\"Q9UBI6\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2\",\"id\":\"P59768\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3\",\"id\":\"P63215\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O60262\",\"P16520\",\"P50150\",\"P50151\",\"P59768\",\"P61952\",\"P62873\",\"P62879\",\"P63211\",\"P63215\",\"P63218\",\"Q00722\",\"Q01970\",\"Q9HAV0\",\"Q9NQ66\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": "[\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNB5\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT1\",\"GNGT10\",\"GNGT11\",\"GNGT2\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT8\",\"GNGT9\",\"KIAA0581\",\"PLCB1\",\"PLCB2\",\"PLCB3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Late Phase of HIV Life Cycle", "protein_name": "[{\"label\":\"Glycylpeptide N-tetradecanoyltransferase 1\",\"id\":\"P30419\"},{\"label\":\"Protein Nef\",\"id\":\"P04601\"}]", "uniprot_id": "[\"P04601\",\"P30419\"]", "gene_symbol": "[\"NMT\",\"NMT1\",\"nef\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PDE3B signalling", "protein_name": "[{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B\",\"id\":\"Q13370\"}]", "uniprot_id": "[\"P31751\",\"Q13370\"]", "gene_symbol": "[\"AKT2\",\"PDE3B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)", "protein_name": "[{\"label\":\"Solute carrier organic anion transporter family member 2A1\",\"id\":\"Q92959\"}]", "uniprot_id": "[\"Q92959\"]", "gene_symbol": "[\"OATP2A1\",\"SLC21A2\",\"SLCO2A1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "pre-mRNA splicing", "protein_name": "[{\"label\":\"116 kDa U5 small nuclear ribonucleoprotein component\",\"id\":\"Q15029\"},{\"label\":\"17S U2 SnRNP complex component HTATSF1\",\"id\":\"O43719\"},{\"label\":\"ATP-dependent RNA helicase A\",\"id\":\"Q08211\"},{\"label\":\"ATP-dependent RNA helicase DDX42\",\"id\":\"Q86XP3\"},{\"label\":\"ATP-dependent RNA helicase DHX15\",\"id\":\"O43143\"},{\"label\":\"ATP-dependent RNA helicase DHX8\",\"id\":\"Q14562\"},{\"label\":\"Apoptotic chromatin condensation inducer in the nucleus\",\"id\":\"Q9UKV3\"},{\"label\":\"BUD13 homolog\",\"id\":\"Q9BRD0\"},{\"label\":\"Beta-catenin-like protein 1\",\"id\":\"Q8WYA6\"},{\"label\":\"CWF19-like protein 2\",\"id\":\"Q2TBE0\"},{\"label\":\"Calcium homeostasis endoplasmic reticulum protein\",\"id\":\"Q8IWX8\"},{\"label\":\"Cell division cycle 5-like protein\",\"id\":\"Q99459\"},{\"label\":\"Cell division cycle and apoptosis regulator protein 1\",\"id\":\"Q8IX12\"},{\"label\":\"Coiled-coil domain-containing protein 12\",\"id\":\"Q8WUD4\"},{\"label\":\"Crooked neck-like protein 1\",\"id\":\"Q9BZJ0\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB11-a\",\"id\":\"P52435\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"DnaJ homolog subfamily C member 8\",\"id\":\"O75937\"},{\"label\":\"E3 ubiquitin-protein ligase RNF113A\",\"id\":\"O15541\"},{\"label\":\"Eukaryotic initiation factor 4A-III\",\"id\":\"P38919\"},{\"label\":\"Exosome RNA helicase MTR4\",\"id\":\"P42285\"},{\"label\":\"G patch domain-containing protein 1\",\"id\":\"Q9BRR8\"},{\"label\":\"G-patch domain and KOW motifs-containing protein\",\"id\":\"Q92917\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein A1\",\"id\":\"P09651\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein A3\",\"id\":\"P51991\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein D0\",\"id\":\"Q14103\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein F\",\"id\":\"P52597\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein H2\",\"id\":\"P55795\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein H\",\"id\":\"P31943\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein K\",\"id\":\"P61978\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein L\",\"id\":\"P14866\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein M\",\"id\":\"P52272\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein R\",\"id\":\"O43390\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein U\",\"id\":\"Q00839\"},{\"label\":\"Heterogeneous nuclear ribonucleoproteins A2/B1\",\"id\":\"P22626\"},{\"label\":\"Heterogeneous nuclear ribonucleoproteins C1/C2\",\"id\":\"P07910\"},{\"label\":\"Histone deacetylase complex subunit SAP18\",\"id\":\"O00422\"},{\"label\":\"Intron Large complex component GCFC2\",\"id\":\"P16383\"},{\"label\":\"Leukocyte receptor cluster member 1\",\"id\":\"Q96BZ8\"},{\"label\":\"Luc7-like protein 3\",\"id\":\"O95232\"},{\"label\":\"Microfibrillar-associated protein 1\",\"id\":\"P55081\"},{\"label\":\"NF-kappa-B-activating protein\",\"id\":\"Q8N5F7\"},{\"label\":\"NHP2-like protein 1\",\"id\":\"P55769\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"Nuclear inhibitor of protein phosphatase 1\",\"id\":\"Q12972\"},{\"label\":\"Nuclear speckle splicing regulatory protein 1\",\"id\":\"Q9H0G5\"},{\"label\":\"PHD finger-like domain-containing protein 5A\",\"id\":\"Q7RTV0\"},{\"label\":\"PRKR-interacting protein 1\",\"id\":\"Q9H875\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase E\",\"id\":\"Q9UNP9\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase G\",\"id\":\"Q13427\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase H\",\"id\":\"O43447\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase-like 1\",\"id\":\"Q9Y3C6\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase-like 3\",\"id\":\"Q9H2H8\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase-like 4\",\"id\":\"Q8WUA2\"},{\"label\":\"Peptidylprolyl isomerase domain and WD repeat-containing protein 1\",\"id\":\"Q96BP3\"},{\"label\":\"Pinin\",\"id\":\"Q9H307\"},{\"label\":\"Pleiotropic regulator 1\",\"id\":\"O43660\"},{\"label\":\"Poly(U)-binding-splicing factor PUF60\",\"id\":\"Q9UHX1\"},{\"label\":\"Poly(rC)-binding protein 1\",\"id\":\"Q15365\"},{\"label\":\"Poly(rC)-binding protein 2\",\"id\":\"Q15366\"},{\"label\":\"Polyglutamine-binding protein 1\",\"id\":\"O60828\"},{\"label\":\"Polypyrimidine tract-binding protein 1\",\"id\":\"P26599\"},{\"label\":\"Pre-mRNA-processing factor 17\",\"id\":\"O60508\"},{\"label\":\"Pre-mRNA-processing factor 19\",\"id\":\"Q9UMS4\"},{\"label\":\"Pre-mRNA-processing factor 40 homolog A\",\"id\":\"O75400\"},{\"label\":\"Pre-mRNA-processing factor 6\",\"id\":\"O94906\"},{\"label\":\"Pre-mRNA-processing-splicing factor 8\",\"id\":\"Q6P2Q9\"},{\"label\":\"Pre-mRNA-splicing factor 18\",\"id\":\"Q99633\"},{\"label\":\"Pre-mRNA-splicing factor 38A\",\"id\":\"Q8NAV1\"},{\"label\":\"Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16\",\"id\":\"O60231\"},{\"label\":\"Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16\",\"id\":\"Q92620\"},{\"label\":\"Pre-mRNA-splicing factor CWC22 homolog\",\"id\":\"Q9HCG8\"},{\"label\":\"Pre-mRNA-splicing factor CWC25 homolog\",\"id\":\"Q9NXE8\"},{\"label\":\"Pre-mRNA-splicing factor ISY1 homolog\",\"id\":\"Q9ULR0\"},{\"label\":\"Pre-mRNA-splicing factor RBM22\",\"id\":\"Q9NW64\"},{\"label\":\"Pre-mRNA-splicing factor SLU7\",\"id\":\"O95391\"},{\"label\":\"Pre-mRNA-splicing factor SPF27\",\"id\":\"O75934\"},{\"label\":\"Pre-mRNA-splicing factor SYF1\",\"id\":\"Q9HCS7\"},{\"label\":\"Pre-mRNA-splicing factor SYF2\",\"id\":\"O95926\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX23\",\"id\":\"Q9BUQ8\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX41\",\"id\":\"Q9UJV9\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX46\",\"id\":\"Q7L014\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX5\",\"id\":\"P17844\"},{\"label\":\"Probable ATP-dependent RNA helicase DHX35\",\"id\":\"Q9H5Z1\"},{\"label\":\"Proline-rich protein PRCC\",\"id\":\"Q92733\"},{\"label\":\"Protein BUD31 homolog\",\"id\":\"P41223\"},{\"label\":\"Protein CASC3\",\"id\":\"O15234\"},{\"label\":\"Protein FAM32A\",\"id\":\"Q9Y421\"},{\"label\":\"Protein FAM50A\",\"id\":\"Q14320\"},{\"label\":\"Protein Red\",\"id\":\"Q13123\"},{\"label\":\"Protein mago nashi homolog 2\",\"id\":\"Q96A72\"},{\"label\":\"Protein mago nashi homolog\",\"id\":\"P61326\"},{\"label\":\"RING-type E3 ubiquitin-protein ligase PPIL2\",\"id\":\"Q13356\"},{\"label\":\"RNA helicase aquarius\",\"id\":\"O60306\"},{\"label\":\"RNA-binding motif protein, X chromosome\",\"id\":\"P38159\"},{\"label\":\"RNA-binding motif protein, X-linked 2\",\"id\":\"Q9Y388\"},{\"label\":\"RNA-binding protein 10\",\"id\":\"P98175\"},{\"label\":\"RNA-binding protein 25\",\"id\":\"P49756\"},{\"label\":\"RNA-binding protein 39\",\"id\":\"Q14498\"},{\"label\":\"RNA-binding protein 42\",\"id\":\"Q9BTD8\"},{\"label\":\"RNA-binding protein 5\",\"id\":\"P52756\"},{\"label\":\"RNA-binding protein 7\",\"id\":\"Q9Y580\"},{\"label\":\"RNA-binding protein 8A\",\"id\":\"Q9Y5S9\"},{\"label\":\"RNA-binding protein FUS\",\"id\":\"P35637\"},{\"label\":\"RNA-binding protein with serine-rich domain 1\",\"id\":\"Q15287\"},{\"label\":\"Regulator of nonsense transcripts 3B\",\"id\":\"Q9BZI7\"},{\"label\":\"SNW domain-containing protein 1\",\"id\":\"Q13573\"},{\"label\":\"STING ER exit protein\",\"id\":\"Q9H5V9\"},{\"label\":\"SURP and G-patch domain-containing protein 1\",\"id\":\"Q8IWZ8\"},{\"label\":\"Serine/arginine repetitive matrix protein 1\",\"id\":\"Q8IYB3\"},{\"label\":\"Serine/arginine repetitive matrix protein 2\",\"id\":\"Q9UQ35\"},{\"label\":\"Serine/arginine-rich splicing factor 10\",\"id\":\"O75494\"},{\"label\":\"Serine/arginine-rich splicing factor 11\",\"id\":\"Q05519\"},{\"label\":\"Serine/arginine-rich splicing factor 12\",\"id\":\"Q8WXF0\"},{\"label\":\"Serine/arginine-rich splicing factor 1\",\"id\":\"Q07955\"},{\"label\":\"Serine/arginine-rich splicing factor 2\",\"id\":\"Q01130\"},{\"label\":\"Serine/arginine-rich splicing factor 3\",\"id\":\"P84103\"},{\"label\":\"Serine/arginine-rich splicing factor 4\",\"id\":\"Q08170\"},{\"label\":\"Serine/arginine-rich splicing factor 5\",\"id\":\"Q13243\"},{\"label\":\"Serine/arginine-rich splicing factor 6\",\"id\":\"Q13247\"},{\"label\":\"Serine/arginine-rich splicing factor 7\",\"id\":\"Q16629\"},{\"label\":\"Serine/arginine-rich splicing factor 8\",\"id\":\"Q9BRL6\"},{\"label\":\"Serine/arginine-rich splicing factor 9\",\"id\":\"Q13242\"},{\"label\":\"Serine/threonine-protein kinase PRP4 homolog\",\"id\":\"Q13523\"},{\"label\":\"Serrate RNA effector molecule homolog\",\"id\":\"Q9BXP5\"},{\"label\":\"Smad nuclear-interacting protein 1\",\"id\":\"Q8TAD8\"},{\"label\":\"Small nuclear ribonucleoprotein E\",\"id\":\"P62304\"},{\"label\":\"Small nuclear ribonucleoprotein F\",\"id\":\"P62306\"},{\"label\":\"Small nuclear ribonucleoprotein G\",\"id\":\"P62308\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D1\",\"id\":\"P62314\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D2\",\"id\":\"P62316\"},{\"label\":\"Small nuclear ribonucleoprotein Sm D3\",\"id\":\"P62318\"},{\"label\":\"Small nuclear ribonucleoprotein-associated protein N\",\"id\":\"P63162\"},{\"label\":\"Small nuclear ribonucleoprotein-associated proteins B and B'\",\"id\":\"P14678\"},{\"label\":\"Spliceosome RNA helicase DDX39B\",\"id\":\"Q13838\"},{\"label\":\"Spliceosome-associated protein CWC15 homolog\",\"id\":\"Q9P013\"},{\"label\":\"Spliceosome-associated protein CWC27 homolog\",\"id\":\"Q6UX04\"},{\"label\":\"Splicing factor 1\",\"id\":\"Q15637\"},{\"label\":\"Splicing factor 3A subunit 1\",\"id\":\"Q15459\"},{\"label\":\"Splicing factor 3A subunit 2\",\"id\":\"Q15428\"},{\"label\":\"Splicing factor 3A subunit 3\",\"id\":\"Q12874\"},{\"label\":\"Splicing factor 3B subunit 1\",\"id\":\"O75533\"},{\"label\":\"Splicing factor 3B subunit 2\",\"id\":\"Q13435\"},{\"label\":\"Splicing factor 3B subunit 3\",\"id\":\"Q15393\"},{\"label\":\"Splicing factor 3B subunit 4\",\"id\":\"Q15427\"},{\"label\":\"Splicing factor 3B subunit 5\",\"id\":\"Q9BWJ5\"},{\"label\":\"Splicing factor 3B subunit 6\",\"id\":\"Q9Y3B4\"},{\"label\":\"Splicing factor 45\",\"id\":\"Q96I25\"},{\"label\":\"Splicing factor C9orf78\",\"id\":\"Q9NZ63\"},{\"label\":\"Splicing factor Cactin\",\"id\":\"Q8WUQ7\"},{\"label\":\"Splicing factor U2AF 26 kDa subunit\",\"id\":\"Q8WU68\"},{\"label\":\"Splicing factor U2AF 35 kDa subunit\",\"id\":\"Q01081\"},{\"label\":\"Splicing factor U2AF 65 kDa subunit\",\"id\":\"P26368\"},{\"label\":\"Splicing factor YJU2\",\"id\":\"Q9BW85\"},{\"label\":\"Splicing regulator SDE2\",\"id\":\"Q6IQ49\"},{\"label\":\"Survival of motor neuron-related-splicing factor 30\",\"id\":\"O75940\"},{\"label\":\"THO complex subunit 4\",\"id\":\"Q86V81\"},{\"label\":\"Thioredoxin-like protein 4A\",\"id\":\"P83876\"},{\"label\":\"Transcription elongation regulator 1\",\"id\":\"O14776\"},{\"label\":\"Transformer-2 protein homolog beta\",\"id\":\"P62995\"},{\"label\":\"Tuftelin-interacting protein 11\",\"id\":\"Q9UBB9\"},{\"label\":\"U1 small nuclear ribonucleoprotein 70 kDa\",\"id\":\"P08621\"},{\"label\":\"U1 small nuclear ribonucleoprotein A\",\"id\":\"P09012\"},{\"label\":\"U1 small nuclear ribonucleoprotein C\",\"id\":\"P09234\"},{\"label\":\"U2 small nuclear ribonucleoprotein A'\",\"id\":\"P09661\"},{\"label\":\"U2 small nuclear ribonucleoprotein B''\",\"id\":\"P08579\"},{\"label\":\"U2 snRNP-associated SURP motif-containing protein\",\"id\":\"O15042\"},{\"label\":\"U4/U6 small nuclear ribonucleoprotein Prp31\",\"id\":\"Q8WWY3\"},{\"label\":\"U4/U6 small nuclear ribonucleoprotein Prp3\",\"id\":\"O43395\"},{\"label\":\"U4/U6 small nuclear ribonucleoprotein Prp4\",\"id\":\"O43172\"},{\"label\":\"U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein\",\"id\":\"Q8WVK2\"},{\"label\":\"U4/U6.U5 tri-snRNP-associated protein 1\",\"id\":\"O43290\"},{\"label\":\"U5 small nuclear ribonucleoprotein 200 kDa helicase\",\"id\":\"O75643\"},{\"label\":\"U5 small nuclear ribonucleoprotein 40 kDa protein\",\"id\":\"Q96DI7\"},{\"label\":\"U6 snRNA-associated Sm-like protein LSm2\",\"id\":\"Q9Y333\"},{\"label\":\"U6 snRNA-associated Sm-like protein LSm3\",\"id\":\"P62310\"},{\"label\":\"U6 snRNA-associated Sm-like protein LSm4\",\"id\":\"Q9Y4Z0\"},{\"label\":\"U6 snRNA-associated Sm-like protein LSm5\",\"id\":\"Q9Y4Y9\"},{\"label\":\"U6 snRNA-associated Sm-like protein LSm6\",\"id\":\"P62312\"},{\"label\":\"U6 snRNA-associated Sm-like protein LSm7\",\"id\":\"Q9UK45\"},{\"label\":\"U6 snRNA-associated Sm-like protein LSm8\",\"id\":\"O95777\"},{\"label\":\"Ubiquitin carboxyl-terminal hydrolase 39\",\"id\":\"Q53GS9\"},{\"label\":\"Ubiquitin-like protein 5\",\"id\":\"Q9BZL1\"},{\"label\":\"WD repeat-containing protein 70\",\"id\":\"Q9NW82\"},{\"label\":\"WD40 repeat-containing protein SMU1\",\"id\":\"Q2TAY7\"},{\"label\":\"WW domain-binding protein 11\",\"id\":\"Q9Y2W2\"},{\"label\":\"WW domain-binding protein 4\",\"id\":\"O75554\"},{\"label\":\"Y-box-binding protein 1\",\"id\":\"P67809\"},{\"label\":\"Zinc finger matrin-type protein 2\",\"id\":\"Q96NC0\"},{\"label\":\"Zinc finger protein 830\",\"id\":\"Q96NB3\"}]", "uniprot_id": 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{ "pathway_label": "VxPx cargo-targeting to cilium", "protein_name": "[{\"label\":\"ADP-ribosylation factor 4\",\"id\":\"P18085\"},{\"label\":\"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1\",\"id\":\"Q9ULH1\"},{\"label\":\"Cyclic nucleotide-gated channel alpha-2\",\"id\":\"Q16280\"},{\"label\":\"Cyclic nucleotide-gated channel alpha-4\",\"id\":\"Q8IV77\"},{\"label\":\"Cyclic nucleotide-gated channel beta-1\",\"id\":\"Q14028\"},{\"label\":\"Exocyst complex component 1\",\"id\":\"Q9NV70\"},{\"label\":\"Exocyst complex component 2\",\"id\":\"Q96KP1\"},{\"label\":\"Exocyst complex component 3\",\"id\":\"O60645\"},{\"label\":\"Exocyst complex component 4\",\"id\":\"Q96A65\"},{\"label\":\"Exocyst complex component 5\",\"id\":\"O00471\"},{\"label\":\"Exocyst complex component 6\",\"id\":\"Q8TAG9\"},{\"label\":\"Exocyst complex component 7\",\"id\":\"Q9UPT5\"},{\"label\":\"Exocyst complex component 8\",\"id\":\"Q8IYI6\"},{\"label\":\"Golgi-specific brefeldin 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C-II\",\"id\":\"P02655\"},{\"label\":\"Cyclic AMP-responsive element-binding protein 3-like protein 3\",\"id\":\"Q68CJ9\"},{\"label\":\"Fibroblast growth factor 21\",\"id\":\"Q9NSA1\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1\",\"id\":\"Q8IV16\"},{\"label\":\"Hepatic triacylglycerol lipase\",\"id\":\"P11150\"},{\"label\":\"Lipase maturation factor 1\",\"id\":\"Q96S06\"},{\"label\":\"Lipase maturation factor 2\",\"id\":\"Q9BU23\"},{\"label\":\"Lipoprotein lipase\",\"id\":\"P06858\"},{\"label\":\"Membrane-bound transcription factor site-1 protease\",\"id\":\"Q14703\"},{\"label\":\"Membrane-bound transcription factor site-2 protease\",\"id\":\"O43462\"},{\"label\":\"Proprotein convertase subtilisin/kexin type 5\",\"id\":\"Q92824\"},{\"label\":\"Proprotein convertase subtilisin/kexin type 6\",\"id\":\"P29122\"}]", "uniprot_id": 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"[\"CADM1\",\"CADM3\",\"HVEB\",\"HVEC\",\"IGSF4\",\"IGSF4A\",\"IGSF4B\",\"LNIR\",\"NECL1\",\"NECL2\",\"NECTIN1\",\"NECTIN2\",\"NECTIN3\",\"NECTIN4\",\"PRR1\",\"PRR2\",\"PRR3\",\"PRR4\",\"PVR\",\"PVRL1\",\"PVRL2\",\"PVRL3\",\"PVRL4\",\"PVS\",\"SYNCAM\",\"SYNCAM3\",\"TSLC1\",\"TSLL1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "O-linked glycosylation", "protein_name": "[{\"label\":\"Beta-1,4-glucuronyltransferase 1\",\"id\":\"O43505\"},{\"label\":\"Dystroglycan 1\",\"id\":\"Q14118\"},{\"label\":\"Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1\",\"id\":\"Q8WZA1\"},{\"label\":\"Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2\",\"id\":\"Q8NAT1\"},{\"label\":\"Protein O-mannose kinase\",\"id\":\"Q9H5K3\"},{\"label\":\"Protein O-mannosyl-transferase 1\",\"id\":\"Q9Y6A1\"},{\"label\":\"Protein O-mannosyl-transferase 2\",\"id\":\"Q9UKY4\"},{\"label\":\"UDP-GalNAc\",\"id\":\"beta-1,3-N-acetylgalactosaminyltransferase 2:Q8NCR0\"},{\"label\":\"Xylosyl- and glucuronyltransferase LARGE1\",\"id\":\"O95461\"},{\"label\":\"Xylosyl- and glucuronyltransferase LARGE2\",\"id\":\"Q8N3Y3\"}]", "uniprot_id": "[\"O43505\",\"O95461\",\"Q14118\",\"Q8N3Y3\",\"Q8NAT1\",\"Q8NCR0\",\"Q8WZA1\",\"Q9H5K3\",\"Q9UKY4\",\"Q9Y6A1\"]", "gene_symbol": "[\"AGO61\",\"B3GALNT2\",\"B3GNT1\",\"B3GNT6\",\"B4GAT1\",\"C3orf39\",\"DAG1\",\"EOGTL\",\"GTDC2\",\"GYLTL1B\",\"KIAA0609\",\"LARGE\",\"LARGE1\",\"LARGE2\",\"MGAT1.2\",\"POMGNT1\",\"POMGNT2\",\"POMK\",\"POMT1\",\"POMT2\",\"SGK196\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "HCMV Late Events", "protein_name": "[{\"label\":\"65 kDa phosphoprotein\",\"id\":\"Q6SW59\"},{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Apoptosis inhibitor UL38\",\"id\":\"F5HG98\"},{\"label\":\"CCAAT/enhancer-binding protein delta\",\"id\":\"P49716\"},{\"label\":\"CEACAM1-like protein UL7\",\"id\":\"Q6SWC3\"},{\"label\":\"Capsid scaffolding protein\",\"id\":\"Q6SW62\"},{\"label\":\"Capsid vertex component 1\",\"id\":\"Q6SW50\"},{\"label\":\"Capsid vertex component 2\",\"id\":\"Q6SW65\"},{\"label\":\"Charged multivesicular body protein 1a\",\"id\":\"Q9HD42\"},{\"label\":\"Charged multivesicular body protein 2a\",\"id\":\"O43633\"},{\"label\":\"Charged multivesicular body protein 2b\",\"id\":\"Q9UQN3\"},{\"label\":\"Charged multivesicular body protein 3\",\"id\":\"Q9Y3E7\"},{\"label\":\"Charged multivesicular body protein 4a\",\"id\":\"Q9BY43\"},{\"label\":\"Charged multivesicular body protein 4b\",\"id\":\"Q9H444\"},{\"label\":\"Charged multivesicular body protein 4c\",\"id\":\"Q96CF2\"},{\"label\":\"Charged multivesicular body protein 6\",\"id\":\"Q96FZ7\"},{\"label\":\"Charged multivesicular body protein 7\",\"id\":\"Q8WUX9\"},{\"label\":\"Chemokine vCXCL1\",\"id\":\"F5HBX1\"},{\"label\":\"Cytoplasmic envelopment protein 1\",\"id\":\"F5HA10\"},{\"label\":\"Cytoplasmic envelopment protein 2\",\"id\":\"F5HAC7\"},{\"label\":\"Cytoplasmic envelopment protein 3\",\"id\":\"F5HI87\"},{\"label\":\"DNA helicase/primase complex-associated protein\",\"id\":\"F5HIG1\"},{\"label\":\"DNA polymerase catalytic subunit\",\"id\":\"Q6SW77\"},{\"label\":\"DNA polymerase processivity factor\",\"id\":\"F5HC97\"},{\"label\":\"DNA primase\",\"id\":\"F5HG51\"},{\"label\":\"DNA replication helicase\",\"id\":\"F5HEN8\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Early phosphoprotein p84\",\"id\":\"Q6SW37\"},{\"label\":\"Envelope glycoprotein B\",\"id\":\"F5HB53\"},{\"label\":\"Envelope glycoprotein H\",\"id\":\"Q6SW67\"},{\"label\":\"Envelope glycoprotein L\",\"id\":\"F5HCH8\"},{\"label\":\"Envelope glycoprotein M\",\"id\":\"Q6SW43\"},{\"label\":\"Envelope glycoprotein N\",\"id\":\"F5HHQ0\"},{\"label\":\"Envelope glycoprotein O\",\"id\":\"F5HGP1\"},{\"label\":\"Envelope glycoprotein UL130\",\"id\":\"F5HCP3\"},{\"label\":\"Envelope glycoprotein UL132\",\"id\":\"F5HGU6\"},{\"label\":\"Glycoprotein UL22A\",\"id\":\"F5HF90\"},{\"label\":\"Heterogeneous nuclear ribonucleoprotein K\",\"id\":\"P61978\"},{\"label\":\"Histone H2A type 1-A\",\"id\":\"Q96QV6\"},{\"label\":\"Histone H2A type 1-B/E\",\"id\":\"P04908\"},{\"label\":\"Histone H2A type 1-C\",\"id\":\"Q93077\"},{\"label\":\"Histone H2A type 1-D\",\"id\":\"P20671\"},{\"label\":\"Histone H2A type 1-H\",\"id\":\"Q96KK5\"},{\"label\":\"Histone H2A type 1-J\",\"id\":\"Q99878\"},{\"label\":\"Histone H2A type 1\",\"id\":\"P0C0S8\"},{\"label\":\"Histone H2A type 2-A\",\"id\":\"Q6FI13\"},{\"label\":\"Histone H2A type 2-B\",\"id\":\"Q8IUE6\"},{\"label\":\"Histone H2A type 2-C\",\"id\":\"Q16777\"},{\"label\":\"Histone H2A type 3\",\"id\":\"Q7L7L0\"},{\"label\":\"Histone H2B type 1-A\",\"id\":\"Q96A08\"},{\"label\":\"Histone H2B type 1-B\",\"id\":\"P33778\"},{\"label\":\"Histone H2B type 1-C/E/F/G/I\",\"id\":\"P62807\"},{\"label\":\"Histone H2B type 1-D\",\"id\":\"P58876\"},{\"label\":\"Histone H2B type 1-H\",\"id\":\"Q93079\"},{\"label\":\"Histone H2B type 1-J\",\"id\":\"P06899\"},{\"label\":\"Histone H2B type 1-K\",\"id\":\"O60814\"},{\"label\":\"Histone H2B type 1-L\",\"id\":\"Q99880\"},{\"label\":\"Histone H2B type 1-M\",\"id\":\"Q99879\"},{\"label\":\"Histone H2B type 1-N\",\"id\":\"Q99877\"},{\"label\":\"Histone H2B type 1-O\",\"id\":\"P23527\"},{\"label\":\"Histone H2B type 2-E\",\"id\":\"Q16778\"},{\"label\":\"Histone H2B type 2-F\",\"id\":\"Q5QNW6\"},{\"label\":\"Histone H2B type 3-B\",\"id\":\"Q8N257\"},{\"label\":\"Histone H3.1\",\"id\":\"P68431\"},{\"label\":\"Histone H3.2\",\"id\":\"Q71DI3\"},{\"label\":\"Histone H4\",\"id\":\"P62805\"},{\"label\":\"Inner tegument protein\",\"id\":\"Q6SW85\"},{\"label\":\"Large tegument protein deneddylase\",\"id\":\"Q6SW84\"},{\"label\":\"Major DNA-binding protein\",\"id\":\"F5HDQ6\"},{\"label\":\"Major capsid protein\",\"id\":\"F5HGT1\"},{\"label\":\"Membrane glycoprotein RL11\",\"id\":\"Q6SWD1\"},{\"label\":\"Membrane glycoprotein 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p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Packaging protein UL32 homolog\",\"id\":\"Q6SW79\"},{\"label\":\"Phosphoprotein 85\",\"id\":\"F5HGJ4\"},{\"label\":\"Portal protein\",\"id\":\"F5HBR4\"},{\"label\":\"Protein IRS1\",\"id\":\"Q6SW04\"},{\"label\":\"Protein RL8A\",\"id\":\"F7V995\"},{\"label\":\"Protein RL9A\",\"id\":\"F7V996\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Protein TRS1\",\"id\":\"Q6SVX2\"},{\"label\":\"Protein UL117\",\"id\":\"F5HFA5\"},{\"label\":\"Protein UL131A\",\"id\":\"F5HET4\"},{\"label\":\"Protein UL29/28\",\"id\":\"Q6SWA3\"},{\"label\":\"Protein UL31\",\"id\":\"Q6SWA0\"},{\"label\":\"Protein UL41A\",\"id\":\"F5HFG3\"},{\"label\":\"Protein UL76\",\"id\":\"Q6SW66\"},{\"label\":\"Protein UL79\",\"id\":\"Q6SW63\"},{\"label\":\"Protein UL84\",\"id\":\"F5HB40\"},{\"label\":\"Protein UL88\",\"id\":\"F5H9F9\"},{\"label\":\"Protein UL91\",\"id\":\"F5HFJ8\"},{\"label\":\"Protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "MASTL Facilitates Mitotic Progression", "protein_name": "[{\"label\":\"Alpha-endosulfine\",\"id\":\"O43768\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"G2/mitotic-specific cyclin-B1\",\"id\":\"P14635\"},{\"label\":\"Serine/threonine-protein kinase greatwall\",\"id\":\"Q96GX5\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform\",\"id\":\"Q66LE6\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform\",\"id\":\"P30154\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform\",\"id\":\"P67775\"},{\"label\":\"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform\",\"id\":\"P62714\"},{\"label\":\"cAMP-regulated phosphoprotein 19\",\"id\":\"P56211\"}]", "uniprot_id": 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1A\",\"id\":\"P0DMV8\"},{\"label\":\"Heat shock 70 kDa protein 1B\",\"id\":\"P0DMV9\"},{\"label\":\"Heat shock factor protein 1\",\"id\":\"Q00613\"},{\"label\":\"Lon protease homolog, mitochondrial\",\"id\":\"P36776\"},{\"label\":\"NAD-dependent protein deacetylase sirtuin-3, mitochondrial\",\"id\":\"Q9NTG7\"},{\"label\":\"Nuclear respiratory factor 1\",\"id\":\"Q16656\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"Serine protease HTRA2, mitochondrial\",\"id\":\"O43464\"},{\"label\":\"Stress-70 protein, mitochondrial\",\"id\":\"P38646\"},{\"label\":\"Superoxide dismutase [Mn], mitochondrial\",\"id\":\"P04179\"}]", "uniprot_id": "[\"O43464\",\"O43524\",\"P03372\",\"P04040\",\"P04179\",\"P0DMV8\",\"P0DMV9\",\"P10809\",\"P31689\",\"P31749\",\"P36776\",\"P38646\",\"P61604\",\"Q00613\",\"Q01523\",\"Q16656\",\"Q9NTG7\",\"Q9Y2D1\"]", "gene_symbol": 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S\",\"id\":\"P25774\"},{\"label\":\"Endoplasmin\",\"id\":\"P14625\"},{\"label\":\"Legumain\",\"id\":\"Q99538\"},{\"label\":\"Procathepsin L\",\"id\":\"P07711\"},{\"label\":\"Protein canopy homolog 3\",\"id\":\"Q9BT09\"},{\"label\":\"Protein unc-93 homolog B1\",\"id\":\"Q9H1C4\"},{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"},{\"label\":\"Toll-like receptor 7\",\"id\":\"Q9NYK1\"},{\"label\":\"Toll-like receptor 8\",\"id\":\"Q9NR97\"},{\"label\":\"Toll-like receptor 9\",\"id\":\"Q9NR96\"}]", "uniprot_id": "[\"O15455\",\"O60911\",\"P07711\",\"P07858\",\"P14625\",\"P25774\",\"P43235\",\"Q99538\",\"Q9BT09\",\"Q9H1C4\",\"Q9NR96\",\"Q9NR97\",\"Q9NYK1\"]", "gene_symbol": "[\"CATL2\",\"CNPY3\",\"CPSB\",\"CTG4A\",\"CTSB\",\"CTSK\",\"CTSL\",\"CTSL1\",\"CTSL2\",\"CTSO\",\"CTSO2\",\"CTSS\",\"CTSU\",\"CTSV\",\"ERDA5\",\"GRP94\",\"HSP90B1\",\"HSPC4\",\"LGMN\",\"PRAT4A\",\"PRSC1\",\"TLR3\",\"TLR7\",\"TLR8\",\"TLR9\",\"TNRC5\",\"TRA1\",\"UNC93\",\"UNC93B\",\"UNC93B1\"]", "gtc_id": "[\"\"]" }, { 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serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 3\",\"id\":\"Q9Y572\"},{\"label\":\"Ribonucleoside-diphosphate reductase large subunit\",\"id\":\"P08543\"},{\"label\":\"Serine proteinase inhibitor 2\",\"id\":\"P07385\"},{\"label\":\"Serine proteinase inhibitor 2\",\"id\":\"P15059\"},{\"label\":\"Uncharacterized protein UL36\",\"id\":\"P16767\"}]", "uniprot_id": "[\"P03496\",\"P07385\",\"P08543\",\"P15059\",\"P16767\",\"P59632\",\"Q13546\",\"Q14790\",\"Q8NB16\",\"Q9Y572\"]", "gene_symbol": "[\"3a\",\"CASP8\",\"ICP6\",\"MCH5\",\"MLKL\",\"NS\",\"OPG199\",\"RIP\",\"RIP1\",\"RIP3\",\"RIPK1\",\"RIPK3\",\"RIR1\",\"SPI-2\",\"UL36\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC9A9 causes autism 16 (AUTS16)", "protein_name": "[{\"label\":\"Sodium/hydrogen exchanger 9\",\"id\":\"Q8IVB4\"}]", "uniprot_id": "[\"Q8IVB4\"]", "gene_symbol": "[\"NHE9\",\"SLC9A9\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Sema4D induced cell migration and growth-cone collapse", "protein_name": "[{\"label\":\"LIM domain kinase 1\",\"id\":\"P53667\"},{\"label\":\"LIM domain kinase 2\",\"id\":\"P53671\"},{\"label\":\"Myosin light polypeptide 6\",\"id\":\"P60660\"},{\"label\":\"Myosin regulatory light chain 12B\",\"id\":\"O14950\"},{\"label\":\"Myosin regulatory light polypeptide 9\",\"id\":\"P24844\"},{\"label\":\"Myosin-10\",\"id\":\"P35580\"},{\"label\":\"Myosin-11\",\"id\":\"P35749\"},{\"label\":\"Myosin-14\",\"id\":\"Q7Z406\"},{\"label\":\"Myosin-9\",\"id\":\"P35579\"},{\"label\":\"Plexin-B1\",\"id\":\"O43157\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"},{\"label\":\"Rho guanine nucleotide exchange factor 11\",\"id\":\"O15085\"},{\"label\":\"Rho guanine nucleotide exchange factor 12\",\"id\":\"Q9NZN5\"},{\"label\":\"Rho-associated protein kinase 1\",\"id\":\"Q13464\"},{\"label\":\"Rho-associated protein kinase 2\",\"id\":\"O75116\"},{\"label\":\"Rho-related GTP-binding protein 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factor beta-1 proprotein\",\"id\":\"P01137\"}]", "uniprot_id": "[\"P01137\",\"P03468\",\"P0C0U1\",\"P12236\"]", "gene_symbol": "[\"AAC3\",\"ANT3\",\"NA\",\"PB1\",\"SLC25A6\",\"TGFB\",\"TGFB1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX3 regulates p14-ARF", "protein_name": "[{\"label\":\"Bromodomain-containing protein 2\",\"id\":\"P25440\"},{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"GTPase KRas\",\"id\":\"P01116\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Histone deacetylase 4\",\"id\":\"P56524\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"},{\"label\":\"Runt-related transcription factor 3\",\"id\":\"Q13761\"},{\"label\":\"Transforming growth factor beta-1 proprotein\",\"id\":\"P01137\"}]", "uniprot_id": "[\"P01116\",\"P01137\",\"P24385\",\"P25440\",\"P56524\",\"Q01196\",\"Q09472\",\"Q13761\",\"Q13951\"]", "gene_symbol": 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"[\"O43320\",\"O76093\",\"P05230\",\"P08620\",\"P09038\",\"P22607\",\"P31371\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF16\",\"FGF18\",\"FGF2\",\"FGF20\",\"FGF23\",\"FGF4\",\"FGF9\",\"FGFA\",\"FGFB\",\"FGFR3\",\"HST\",\"HSTF1\",\"HYPF\",\"JTK4\",\"KS3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Erythropoietin activates STAT5", "protein_name": "[{\"label\":\"Erythropoietin receptor\",\"id\":\"P19235\"},{\"label\":\"Erythropoietin\",\"id\":\"P01588\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"}]", "uniprot_id": "[\"O60674\",\"P01588\",\"P07948\",\"P19235\",\"P42229\",\"P51692\",\"Q9Y4H2\"]", "gene_symbol": "[\"EPO\",\"EPOR\",\"IRS2\",\"JAK2\",\"JTK8\",\"LYN\",\"STAT5\",\"STAT5A\",\"STAT5B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of TP53 Activity through Association with Co-factors", "protein_name": "[{\"label\":\"Apoptosis-stimulating of p53 protein 1\",\"id\":\"Q96KQ4\"},{\"label\":\"Apoptosis-stimulating of p53 protein 2\",\"id\":\"Q13625\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"PHD finger protein 20\",\"id\":\"Q9BVI0\"},{\"label\":\"POU domain, class 4, transcription factor 1\",\"id\":\"Q01851\"},{\"label\":\"POU domain, class 4, transcription factor 2\",\"id\":\"Q12837\"},{\"label\":\"Protein BANP\",\"id\":\"Q8N9N5\"},{\"label\":\"RAC-alpha serine/threonine-protein kinase\",\"id\":\"P31749\"},{\"label\":\"RAC-beta serine/threonine-protein kinase\",\"id\":\"P31751\"},{\"label\":\"RAC-gamma serine/threonine-protein kinase\",\"id\":\"Q9Y243\"},{\"label\":\"RelA-associated inhibitor\",\"id\":\"Q8WUF5\"},{\"label\":\"Tumor protein 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3\",\"id\":\"Q6UUV7\"},{\"label\":\"Casein kinase I isoform delta\",\"id\":\"P48730\"},{\"label\":\"Casein kinase I isoform epsilon\",\"id\":\"P49674\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 9\",\"id\":\"Q3L8U1\"},{\"label\":\"Circadian locomoter output cycles protein kaput\",\"id\":\"O15516\"},{\"label\":\"Class E basic helix-loop-helix protein 41\",\"id\":\"Q9C0J9\"},{\"label\":\"Cryptochrome-1\",\"id\":\"Q16526\"},{\"label\":\"Cryptochrome-2\",\"id\":\"Q49AN0\"},{\"label\":\"Cullin-1\",\"id\":\"Q13616\"},{\"label\":\"Cyclic AMP-dependent transcription factor ATF-2\",\"id\":\"P15336\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1X\",\"id\":\"O60907\"},{\"label\":\"F-box-like/WD repeat-containing protein TBL1XR1\",\"id\":\"Q9BZK7\"},{\"label\":\"F-box/LRR-repeat protein 3\",\"id\":\"Q9UKT7\"},{\"label\":\"F-box/WD repeat-containing protein 1A\",\"id\":\"Q9Y297\"},{\"label\":\"Glucocorticoid receptor\",\"id\":\"P04150\"},{\"label\":\"Histone 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corepressor 1\",\"id\":\"O75376\"},{\"label\":\"Nuclear receptor subfamily 1 group D member 1\",\"id\":\"P20393\"},{\"label\":\"Nuclear receptor-interacting protein 1\",\"id\":\"P48552\"},{\"label\":\"Period circadian protein homolog 1\",\"id\":\"O15534\"},{\"label\":\"Period circadian protein homolog 2\",\"id\":\"O15055\"},{\"label\":\"Peroxisome proliferator-activated receptor alpha\",\"id\":\"Q07869\"},{\"label\":\"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha\",\"id\":\"Q9UBK2\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"RNA-binding protein 4\",\"id\":\"Q9BWF3\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"},{\"label\":\"Retinoic acid-induced protein 1\",\"id\":\"Q7Z5J4\"},{\"label\":\"S-phase kinase-associated protein 1\",\"id\":\"P63208\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3\",\"id\":\"Q6STE5\"},{\"label\":\"Serine/threonine-protein kinase SIK1\",\"id\":\"P57059\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-alpha catalytic subunit\",\"id\":\"P62136\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-beta catalytic subunit\",\"id\":\"P62140\"},{\"label\":\"Serine/threonine-protein phosphatase PP1-gamma catalytic subunit\",\"id\":\"P36873\"},{\"label\":\"Trimethylguanosine synthase\",\"id\":\"Q96RS0\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Glycerophospholipid biosynthesis", "protein_name": "[{\"label\":\"Acylglycerol kinase, mitochondrial\",\"id\":\"Q53H12\"},{\"label\":\"Copine-1\",\"id\":\"Q99829\"},{\"label\":\"Copine-3\",\"id\":\"O75131\"},{\"label\":\"Copine-6\",\"id\":\"O95741\"},{\"label\":\"Copine-7\",\"id\":\"Q9UBL6\"}]", "uniprot_id": "[\"O75131\",\"O95741\",\"Q53H12\",\"Q99829\",\"Q9UBL6\"]", "gene_symbol": "[\"AGK\",\"CPN1\",\"CPN3\",\"CPNE1\",\"CPNE3\",\"CPNE6\",\"CPNE7\",\"KIAA0636\",\"MULK\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RIP-mediated NFkB activation via ZBP1", "protein_name": "[{\"label\":\"ATP-dependent RNA helicase A\",\"id\":\"Q08211\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit alpha\",\"id\":\"O15111\"},{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit beta\",\"id\":\"O14920\"},{\"label\":\"Myeloid differentiation primary response protein MyD88\",\"id\":\"Q99836\"},{\"label\":\"NF-kappa-B essential modulator\",\"id\":\"Q9Y6K9\"},{\"label\":\"NF-kappa-B inhibitor alpha\",\"id\":\"P25963\"},{\"label\":\"NF-kappa-B inhibitor beta\",\"id\":\"Q15653\"},{\"label\":\"NF-kappa-B inhibitor-interacting Ras-like protein 1\",\"id\":\"Q9NYS0\"},{\"label\":\"NF-kappa-B inhibitor-interacting Ras-like protein 2\",\"id\":\"Q9NYR9\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 3\",\"id\":\"Q9Y572\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"},{\"label\":\"Z-DNA-binding protein 1\",\"id\":\"Q9H171\"}]", "uniprot_id": 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(ascorbate) metabolism", "protein_name": "[{\"label\":\"Cytochrome b5\",\"id\":\"P00167\"},{\"label\":\"Glutathione S-transferase omega-1\",\"id\":\"P78417\"},{\"label\":\"Glutathione S-transferase omega-2\",\"id\":\"Q9H4Y5\"},{\"label\":\"NADH-cytochrome b5 reductase 3\",\"id\":\"P00387\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 1\",\"id\":\"P11166\"},{\"label\":\"Solute carrier family 2, facilitated glucose transporter member 3\",\"id\":\"P11169\"},{\"label\":\"Solute carrier family 23 member 1\",\"id\":\"Q9UHI7\"},{\"label\":\"Solute carrier family 23 member 2\",\"id\":\"Q9UGH3\"}]", "uniprot_id": "[\"P00167\",\"P00387\",\"P11166\",\"P11169\",\"P78417\",\"Q9H4Y5\",\"Q9UGH3\",\"Q9UHI7\"]", "gene_symbol": "[\"CYB5\",\"CYB5A\",\"CYB5R3\",\"DIA1\",\"GLUT1\",\"GLUT3\",\"GSTO1\",\"GSTO2\",\"GSTTLP28\",\"KIAA0238\",\"NBTL1\",\"SLC23A1\",\"SLC23A2\",\"SLC2A1\",\"SLC2A3\",\"SVCT1\",\"SVCT2\",\"YSPL2\",\"YSPL3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": 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"[\"G49108TO\",\"G57321FI\"]" }, { "pathway_label": "SHC-mediated cascade:FGFR3", "protein_name": "[{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O43320\",\"O76093\",\"P01111\",\"P01112\",\"P05230\",\"P08620\",\"P09038\",\"P31371\",\"Q07889\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": 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SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Importin subunit alpha-5\",\"id\":\"P52294\"},{\"label\":\"Importin subunit beta-1\",\"id\":\"Q14974\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Nucleoprotein\",\"id\":\"P03466\"},{\"label\":\"Polymerase acidic protein\",\"id\":\"P03433\"},{\"label\":\"Polymerase basic protein 2\",\"id\":\"P03428\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"RNA-directed RNA polymerase catalytic subunit\",\"id\":\"P03431\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"}]", "uniprot_id": "[\"A8CG34\",\"O15504\",\"O75694\",\"P03428\",\"P03431\",\"P03433\",\"P03466\",\"P12270\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P52294\",\"P55735\",\"P57740\",\"P78406\",\"Q12769\",\"Q14974\",\"Q5SRE5\",\"Q7Z3B4\",\"Q8N1F7\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q92621\",\"Q96HA1\",\"Q99567\",\"Q9BTX1\",\"Q9BW27\",\"Q9NRG9\",\"Q9UKX7\"]", "gene_symbol": 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"[\"GABBR1\",\"GABBR2\",\"GPR51\",\"GPRC3A\",\"GPRC3B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of the ternary complex, and subsequently, the 43S complex", "protein_name": "[{\"label\":\"Eukaryotic translation initiation factor 1A, X-chromosomal\",\"id\":\"P47813\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 1\",\"id\":\"P05198\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 2\",\"id\":\"P20042\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 3\",\"id\":\"P41091\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit A\",\"id\":\"Q14152\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit B\",\"id\":\"P55884\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit C\",\"id\":\"Q99613\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit D\",\"id\":\"O15371\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit E\",\"id\":\"P60228\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit F\",\"id\":\"O00303\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit G\",\"id\":\"O75821\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit H\",\"id\":\"O15372\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit I\",\"id\":\"Q13347\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit J\",\"id\":\"O75822\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit K\",\"id\":\"Q9UBQ5\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit L\",\"id\":\"Q9Y262\"},{\"label\":\"Eukaryotic translation initiation factor 3 subunit M\",\"id\":\"Q7L2H7\"},{\"label\":\"Ribosomal protein eS27-like\",\"id\":\"Q71UM5\"},{\"label\":\"Small ribosomal subunit protein eS10\",\"id\":\"P46783\"},{\"label\":\"Small ribosomal subunit protein eS12\",\"id\":\"P25398\"},{\"label\":\"Small ribosomal subunit protein eS17\",\"id\":\"P08708\"},{\"label\":\"Small ribosomal subunit protein eS19\",\"id\":\"P39019\"},{\"label\":\"Small ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS4, X isoform\",\"id\":\"P62701\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 1\",\"id\":\"P22090\"},{\"label\":\"Small ribosomal subunit protein eS4, Y isoform 2\",\"id\":\"Q8TD47\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein eS7\",\"id\":\"P62081\"},{\"label\":\"Small ribosomal subunit protein eS8\",\"id\":\"P62241\"},{\"label\":\"Small ribosomal subunit protein uS10\",\"id\":\"P60866\"},{\"label\":\"Small ribosomal subunit protein uS11\",\"id\":\"P62263\"},{\"label\":\"Small ribosomal subunit protein uS12\",\"id\":\"P62266\"},{\"label\":\"Small ribosomal subunit protein uS13\",\"id\":\"P62269\"},{\"label\":\"Small ribosomal subunit protein uS14\",\"id\":\"P62273\"},{\"label\":\"Small ribosomal subunit protein uS15\",\"id\":\"P62277\"},{\"label\":\"Small ribosomal subunit protein uS17\",\"id\":\"P62280\"},{\"label\":\"Small ribosomal subunit protein uS19\",\"id\":\"P62841\"},{\"label\":\"Small ribosomal subunit protein uS2\",\"id\":\"P08865\"},{\"label\":\"Small ribosomal subunit protein uS3\",\"id\":\"P23396\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small ribosomal subunit protein uS7\",\"id\":\"P46782\"},{\"label\":\"Small ribosomal subunit protein uS8\",\"id\":\"P62244\"},{\"label\":\"Small ribosomal subunit protein uS9\",\"id\":\"P62249\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00303\",\"O15371\",\"O15372\",\"O75821\",\"O75822\",\"P05198\",\"P08708\",\"P08865\",\"P15880\",\"P20042\",\"P22090\",\"P23396\",\"P25398\",\"P39019\",\"P41091\",\"P42677\",\"P46781\",\"P46782\",\"P46783\",\"P47813\",\"P55884\",\"P60228\",\"P60866\",\"P61247\",\"P62081\",\"P62241\",\"P62244\",\"P62249\",\"P62263\",\"P62266\",\"P62269\",\"P62273\",\"P62277\",\"P62280\",\"P62701\",\"P62753\",\"P62841\",\"P62847\",\"P62851\",\"P62854\",\"P62857\",\"P62861\",\"P62979\",\"P63220\",\"Q13347\",\"Q14152\",\"Q71UM5\",\"Q7L2H7\",\"Q8TD47\",\"Q99613\",\"Q9UBQ5\",\"Q9Y262\"]", "gene_symbol": 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alpha-13\",\"id\":\"Q14344\"},{\"label\":\"Intersectin-1\",\"id\":\"Q15811\"},{\"label\":\"Kalirin\",\"id\":\"O60229\"},{\"label\":\"Melanoma-associated antigen D1\",\"id\":\"Q9Y5V3\"},{\"label\":\"Mitogen-activated protein kinase 8\",\"id\":\"P45983\"},{\"label\":\"Neuroepithelial cell-transforming gene 1 protein\",\"id\":\"Q7Z628\"},{\"label\":\"Obscurin\",\"id\":\"Q5VST9\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Pleckstrin homology domain-containing family G member 2\",\"id\":\"Q9H7P9\"},{\"label\":\"Pleckstrin homology domain-containing family G member 5\",\"id\":\"O94827\"},{\"label\":\"Protein AATF\",\"id\":\"Q9NY61\"},{\"label\":\"Protein ECT2\",\"id\":\"Q9H8V3\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Ras-specific guanine nucleotide-releasing factor 2\",\"id\":\"O14827\"},{\"label\":\"Rho guanine nucleotide exchange factor 10-like protein\",\"id\":\"Q9HCE6\"},{\"label\":\"Rho guanine nucleotide exchange factor 10\",\"id\":\"O15013\"},{\"label\":\"Rho guanine nucleotide exchange factor 11\",\"id\":\"O15085\"},{\"label\":\"Rho guanine nucleotide exchange factor 12\",\"id\":\"Q9NZN5\"},{\"label\":\"Rho guanine nucleotide exchange factor 15\",\"id\":\"O94989\"},{\"label\":\"Rho guanine nucleotide exchange factor 16\",\"id\":\"Q5VV41\"},{\"label\":\"Rho guanine nucleotide exchange factor 17\",\"id\":\"Q96PE2\"},{\"label\":\"Rho guanine nucleotide exchange factor 18\",\"id\":\"Q6ZSZ5\"},{\"label\":\"Rho guanine nucleotide exchange factor 19\",\"id\":\"Q8IW93\"},{\"label\":\"Rho guanine nucleotide exchange factor 1\",\"id\":\"Q92888\"},{\"label\":\"Rho guanine nucleotide exchange factor 26\",\"id\":\"Q96DR7\"},{\"label\":\"Rho guanine nucleotide exchange factor 2\",\"id\":\"Q92974\"},{\"label\":\"Rho guanine nucleotide exchange 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)", "protein_name": "[{\"label\":\"High affinity choline transporter 1\",\"id\":\"Q9GZV3\"}]", "uniprot_id": "[\"Q9GZV3\"]", "gene_symbol": "[\"CHT1\",\"SLC5A7\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Glycolysis", "protein_name": "[{\"label\":\"ADP-dependent glucokinase\",\"id\":\"Q9BRR6\"},{\"label\":\"ATP-dependent 6-phosphofructokinase, liver type\",\"id\":\"P17858\"},{\"label\":\"ATP-dependent 6-phosphofructokinase, muscle type\",\"id\":\"P08237\"},{\"label\":\"ATP-dependent 6-phosphofructokinase, platelet type\",\"id\":\"Q01813\"},{\"label\":\"Alpha-enolase\",\"id\":\"P06733\"},{\"label\":\"Beta-enolase\",\"id\":\"P13929\"},{\"label\":\"Bisphosphoglycerate mutase\",\"id\":\"P07738\"},{\"label\":\"Enolase 4\",\"id\":\"A6NNW6\"},{\"label\":\"Fructose-bisphosphate aldolase A\",\"id\":\"P04075\"},{\"label\":\"Fructose-bisphosphate aldolase B\",\"id\":\"P05062\"},{\"label\":\"Fructose-bisphosphate aldolase C\",\"id\":\"P09972\"},{\"label\":\"Gamma-enolase\",\"id\":\"P09104\"},{\"label\":\"Glucosamine-6-phosphate isomerase 1\",\"id\":\"P46926\"},{\"label\":\"Glucosamine-6-phosphate isomerase 2\",\"id\":\"Q8TDQ7\"},{\"label\":\"Glucose 1,6-bisphosphate synthase\",\"id\":\"Q6PCE3\"},{\"label\":\"Glucose-6-phosphate isomerase\",\"id\":\"P06744\"},{\"label\":\"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific\",\"id\":\"O14556\"},{\"label\":\"Glyceraldehyde-3-phosphate dehydrogenase\",\"id\":\"P04406\"},{\"label\":\"Glycerol-3-phosphate phosphatase\",\"id\":\"A6NDG6\"},{\"label\":\"Hexokinase HKDC1\",\"id\":\"Q2TB90\"},{\"label\":\"Hexokinase-1\",\"id\":\"P19367\"},{\"label\":\"Hexokinase-2\",\"id\":\"P52789\"},{\"label\":\"Hexokinase-3\",\"id\":\"P52790\"},{\"label\":\"Hexokinase-4\",\"id\":\"P35557\"},{\"label\":\"Phosphoglycerate kinase 1\",\"id\":\"P00558\"},{\"label\":\"Phosphoglycerate kinase 2\",\"id\":\"P07205\"},{\"label\":\"Phosphoglycerate mutase 1\",\"id\":\"P18669\"},{\"label\":\"Phosphoglycerate mutase 2\",\"id\":\"P15259\"},{\"label\":\"Triosephosphate isomerase\",\"id\":\"P60174\"}]", "uniprot_id": "[\"A6NDG6\",\"A6NNW6\",\"O14556\",\"P00558\",\"P04075\",\"P04406\",\"P05062\",\"P06733\",\"P06744\",\"P07205\",\"P07738\",\"P08237\",\"P09104\",\"P09972\",\"P13929\",\"P15259\",\"P17858\",\"P18669\",\"P19367\",\"P35557\",\"P46926\",\"P52789\",\"P52790\",\"P60174\",\"Q01813\",\"Q2TB90\",\"Q6PCE3\",\"Q8TDQ7\",\"Q9BRR6\"]", "gene_symbol": "[\"ADPGK\",\"ALDA\",\"ALDB\",\"ALDC\",\"ALDOA\",\"ALDOB\",\"ALDOC\",\"BM32A\",\"BPGM\",\"C10orf134\",\"ENO1\",\"ENO1L1\",\"ENO2\",\"ENO3\",\"ENO4\",\"GAPD\",\"GAPD2\",\"GAPDH\",\"GAPDH2\",\"GAPDHS\",\"GAPDS\",\"GCK\",\"GNP2\",\"GNPDA1\",\"GNPDA2\",\"GNPI\",\"GPI\",\"HK1\",\"HK2\",\"HK3\",\"HKDC1\",\"HLN\",\"KIAA0060\",\"MBPB1\",\"MPB1\",\"PFKF\",\"PFKL\",\"PFKM\",\"PFKP\",\"PFKX\",\"PGAM1\",\"PGAM2\",\"PGAMA\",\"PGAMM\",\"PGK1\",\"PGK2\",\"PGKA\",\"PGKB\",\"PGM2L1\",\"PGP\",\"TPI\",\"TPI1\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "Interleukin-10 signaling", "protein_name": "[{\"label\":\"C-C chemokine receptor type 1\",\"id\":\"P32246\"},{\"label\":\"C-C chemokine receptor type 2\",\"id\":\"P41597\"},{\"label\":\"C-C chemokine receptor type 5\",\"id\":\"P51681\"},{\"label\":\"C-C motif chemokine 19\",\"id\":\"Q99731\"},{\"label\":\"C-C motif chemokine 20\",\"id\":\"P78556\"},{\"label\":\"C-C motif chemokine 22\",\"id\":\"O00626\"},{\"label\":\"C-C motif chemokine 2\",\"id\":\"P13500\"},{\"label\":\"C-C motif chemokine 3-like 1\",\"id\":\"P16619\"},{\"label\":\"C-C motif chemokine 3\",\"id\":\"P10147\"},{\"label\":\"C-C motif chemokine 4\",\"id\":\"P13236\"},{\"label\":\"C-C motif chemokine 5\",\"id\":\"P13501\"},{\"label\":\"C-X-C motif chemokine 10\",\"id\":\"P02778\"},{\"label\":\"C-X-C motif chemokine 2\",\"id\":\"P19875\"},{\"label\":\"Granulocyte colony-stimulating factor\",\"id\":\"P09919\"},{\"label\":\"Granulocyte-macrophage colony-stimulating factor\",\"id\":\"P04141\"},{\"label\":\"Growth-regulated alpha protein\",\"id\":\"P09341\"},{\"label\":\"Intercellular adhesion molecule 1\",\"id\":\"P05362\"},{\"label\":\"Interleukin-1 alpha\",\"id\":\"P01583\"},{\"label\":\"Interleukin-1 beta\",\"id\":\"P01584\"},{\"label\":\"Interleukin-1 receptor antagonist protein\",\"id\":\"P18510\"},{\"label\":\"Interleukin-1 receptor type 1\",\"id\":\"P14778\"},{\"label\":\"Interleukin-1 receptor type 2\",\"id\":\"P27930\"},{\"label\":\"Interleukin-10 receptor subunit alpha\",\"id\":\"Q13651\"},{\"label\":\"Interleukin-10 receptor subunit beta\",\"id\":\"Q08334\"},{\"label\":\"Interleukin-10\",\"id\":\"P22301\"},{\"label\":\"Interleukin-12 subunit alpha\",\"id\":\"P29459\"},{\"label\":\"Interleukin-12 subunit beta\",\"id\":\"P29460\"},{\"label\":\"Interleukin-18\",\"id\":\"Q14116\"},{\"label\":\"Interleukin-6\",\"id\":\"P05231\"},{\"label\":\"Interleukin-8\",\"id\":\"P10145\"},{\"label\":\"Leukemia inhibitory factor\",\"id\":\"P15018\"},{\"label\":\"Low affinity immunoglobulin epsilon Fc receptor\",\"id\":\"P06734\"},{\"label\":\"Macrophage colony-stimulating factor 1\",\"id\":\"P09603\"},{\"label\":\"Metalloproteinase inhibitor 1\",\"id\":\"P01033\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Platelet-activating factor receptor\",\"id\":\"P25105\"},{\"label\":\"Prostaglandin G/H synthase 2\",\"id\":\"P35354\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"T-lymphocyte activation antigen CD80\",\"id\":\"P33681\"},{\"label\":\"T-lymphocyte activation antigen CD86\",\"id\":\"P42081\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 1A\",\"id\":\"P19438\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 1B\",\"id\":\"P20333\"},{\"label\":\"Tumor necrosis factor\",\"id\":\"P01375\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"fMet-Leu-Phe receptor\",\"id\":\"P21462\"}]", "uniprot_id": 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"[\"APRF\",\"C17orf33\",\"CCL19\",\"CCL2\",\"CCL20\",\"CCL22\",\"CCL3\",\"CCL3L1\",\"CCL3L3\",\"CCL4\",\"CCL5\",\"CCR1\",\"CCR2\",\"CCR5\",\"CD23A\",\"CD28LG\",\"CD28LG1\",\"CD28LG2\",\"CD80\",\"CD86\",\"CLEC4J\",\"CLGI\",\"CMKBR1\",\"CMKBR2\",\"CMKBR5\",\"CMKR1\",\"COX2\",\"CRFB4\",\"CSF1\",\"CSF2\",\"CSF3\",\"CXCL1\",\"CXCL10\",\"CXCL2\",\"CXCL8\",\"D17S136E\",\"D17S1718\",\"D21S58\",\"D21S66\",\"ELC\",\"FCE2\",\"FCER2\",\"FPR1\",\"G0S19-1\",\"G0S19-2\",\"GCSF\",\"GMCSF\",\"GRO\",\"GRO1\",\"GRO2\",\"GROA\",\"GROB\",\"HILDA\",\"ICAM1\",\"IFNB2\",\"IGEBF\",\"IGIF\",\"IL10\",\"IL10R\",\"IL10RA\",\"IL10RB\",\"IL12A\",\"IL12B\",\"IL18\",\"IL1A\",\"IL1B\",\"IL1F1\",\"IL1F2\",\"IL1F3\",\"IL1F4\",\"IL1R\",\"IL1R1\",\"IL1R2\",\"IL1RA\",\"IL1RB\",\"IL1RN\",\"IL1RT1\",\"IL6\",\"IL8\",\"INP10\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"LAB7\",\"LAG1\",\"LARC\",\"LIF\",\"MCP1\",\"MDC\",\"MGSA\",\"MIP1A\",\"MIP1B\",\"MIP2A\",\"MIP3A\",\"MIP3B\",\"NKSF1\",\"NKSF2\",\"PAFR\",\"PTAFR\",\"PTGS2\",\"SCYA19\",\"SCYA2\",\"SCYA20\",\"SCYA22\",\"SCYA3\",\"SCYA3L1\",\"SCYA4\",\"SCYA5\",\"SCYAR1\",\"SCYB1\",\"SCYB10\",\"SCYB2\",\"STAT3\",\"TIMP\",\"TIMP1\",\"TNF\",\"TNFA\",\"TNFAR\",\"TNFBR\",\"TNFR1\",\"TNFR2\",\"TNFRSF1A\",\"TNFRSF1B\",\"TNFSF2\",\"TYK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "semaxanib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Scavenging by Class A Receptors", "protein_name": "[{\"label\":\"Apolipoprotein A-I\",\"id\":\"P02647\"},{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Apolipoprotein E\",\"id\":\"P02649\"},{\"label\":\"Calreticulin\",\"id\":\"P27797\"},{\"label\":\"Collagen alpha-1(I) chain\",\"id\":\"P02452\"},{\"label\":\"Collagen alpha-1(III) chain\",\"id\":\"P02461\"},{\"label\":\"Collagen alpha-1(IV) chain\",\"id\":\"P02462\"},{\"label\":\"Collagen alpha-2(I) chain\",\"id\":\"P08123\"},{\"label\":\"Collagen alpha-2(IV) chain\",\"id\":\"P08572\"},{\"label\":\"Collectin-11\",\"id\":\"Q9BWP8\"},{\"label\":\"Collectin-12\",\"id\":\"Q5KU26\"},{\"label\":\"Endoplasmin\",\"id\":\"P14625\"},{\"label\":\"Ferritin heavy chain\",\"id\":\"P02794\"},{\"label\":\"Ferritin light chain\",\"id\":\"P02792\"},{\"label\":\"Macrophage receptor MARCO\",\"id\":\"Q9UEW3\"},{\"label\":\"Macrophage scavenger receptor types I and II\",\"id\":\"P21757\"},{\"label\":\"Mannan-binding lectin serine protease 1\",\"id\":\"P48740\"},{\"label\":\"Scavenger receptor class A member 5\",\"id\":\"Q6ZMJ2\"},{\"label\":\"Secretoglobin family 3A member 2\",\"id\":\"Q96PL1\"}]", "uniprot_id": "[\"P02452\",\"P02461\",\"P02462\",\"P02647\",\"P02649\",\"P02792\",\"P02794\",\"P04114\",\"P08123\",\"P08572\",\"P14625\",\"P21757\",\"P27797\",\"P48740\",\"Q5KU26\",\"Q6ZMJ2\",\"Q96PL1\",\"Q9BWP8\",\"Q9UEW3\"]", "gene_symbol": 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mitochondrial\",\"id\":\"Q7L8L6\"}]", "uniprot_id": "[\"Q7L8L6\",\"Q969Z0\",\"Q9NYY8\"]", "gene_symbol": "[\"CPR2\",\"FASTKD2\",\"FASTKD4\",\"FASTKD5\",\"KIAA0948\",\"KIAA0971\",\"KIAA1792\",\"TBRG4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Deposition of new CENPA-containing nucleosomes at the centromere", "protein_name": "[{\"label\":\"Centromere protein C\",\"id\":\"Q03188\"},{\"label\":\"Centromere protein H\",\"id\":\"Q9H3R5\"},{\"label\":\"Centromere protein I\",\"id\":\"Q92674\"},{\"label\":\"Centromere protein K\",\"id\":\"Q9BS16\"},{\"label\":\"Centromere protein L\",\"id\":\"Q8N0S6\"},{\"label\":\"Centromere protein M\",\"id\":\"Q9NSP4\"},{\"label\":\"Centromere protein N\",\"id\":\"Q96H22\"},{\"label\":\"Centromere protein O\",\"id\":\"Q9BU64\"},{\"label\":\"Centromere protein P\",\"id\":\"Q6IPU0\"},{\"label\":\"Centromere protein Q\",\"id\":\"Q7L2Z9\"},{\"label\":\"Centromere protein R\",\"id\":\"Q13352\"},{\"label\":\"Centromere protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of PAK-2p34 activity by PS-GAP/RHG10", "protein_name": "[{\"label\":\"Rho GTPase-activating protein 10\",\"id\":\"A1A4S6\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"}]", "uniprot_id": "[\"A1A4S6\",\"Q13177\"]", "gene_symbol": "[\"ARHGAP10\",\"GRAF2\",\"PAK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "LDL clearance", "protein_name": "[{\"label\":\"AP-2 complex subunit alpha-1\",\"id\":\"O95782\"},{\"label\":\"AP-2 complex subunit alpha-2\",\"id\":\"O94973\"},{\"label\":\"AP-2 complex subunit beta\",\"id\":\"P63010\"},{\"label\":\"AP-2 complex subunit mu\",\"id\":\"Q96CW1\"},{\"label\":\"AP-2 complex subunit sigma\",\"id\":\"P53680\"},{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"Carboxylesterase 3\",\"id\":\"Q6UWW8\"},{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Clathrin light chain A\",\"id\":\"P09496\"},{\"label\":\"Lipolysis-stimulated lipoprotein receptor\",\"id\":\"Q86X29\"},{\"label\":\"Low density lipoprotein receptor adapter protein 1\",\"id\":\"Q5SW96\"},{\"label\":\"Low-density lipoprotein receptor\",\"id\":\"P01130\"},{\"label\":\"Lysosomal acid lipase/cholesteryl ester hydrolase\",\"id\":\"P38571\"},{\"label\":\"NPC intracellular cholesterol transporter 1\",\"id\":\"O15118\"},{\"label\":\"NPC intracellular cholesterol transporter 2\",\"id\":\"P61916\"},{\"label\":\"Neutral cholesterol ester hydrolase 1\",\"id\":\"Q6PIU2\"},{\"label\":\"Proprotein convertase subtilisin/kexin type 9\",\"id\":\"Q8NBP7\"},{\"label\":\"Sterol O-acyltransferase 1\",\"id\":\"P35610\"},{\"label\":\"Sterol O-acyltransferase 2\",\"id\":\"O75908\"}]", "uniprot_id": "[\"O15118\",\"O75908\",\"O94973\",\"O95782\",\"P01130\",\"P04114\",\"P09496\",\"P35610\",\"P38571\",\"P53680\",\"P61916\",\"P63010\",\"Q00610\",\"Q5SW96\",\"Q6PIU2\",\"Q6UWW8\",\"Q86X29\",\"Q8NBP7\",\"Q96CW1\"]", "gene_symbol": 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sigma\",\"id\":\"P53680\"},{\"label\":\"AT-rich interactive domain-containing protein 4A\",\"id\":\"P29374\"},{\"label\":\"AT-rich interactive domain-containing protein 4B\",\"id\":\"Q4LE39\"},{\"label\":\"Angiotensin-converting enzyme 2\",\"id\":\"Q9BYF1\"},{\"label\":\"B-cell antigen receptor complex-associated protein alpha chain\",\"id\":\"P11912\"},{\"label\":\"B-cell antigen receptor complex-associated protein beta chain\",\"id\":\"P40259\"},{\"label\":\"B-cell linker protein\",\"id\":\"Q8WV28\"},{\"label\":\"Breast cancer metastasis-suppressor 1\",\"id\":\"Q9HCU9\"},{\"label\":\"Bromodomain-containing protein 4\",\"id\":\"O60885\"},{\"label\":\"Catechol O-methyltransferase\",\"id\":\"P21964\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 3\",\"id\":\"Q12873\"},{\"label\":\"Chromodomain-helicase-DNA-binding protein 4\",\"id\":\"Q14839\"},{\"label\":\"Cullin-3\",\"id\":\"Q13618\"},{\"label\":\"Cysteinyl leukotriene receptor 1\",\"id\":\"Q9Y271\"},{\"label\":\"E3 ubiquitin-protein ligase RBX1\",\"id\":\"P62877\"},{\"label\":\"FXYD domain-containing ion transport regulator 3\",\"id\":\"Q14802\"},{\"label\":\"FXYD domain-containing ion transport regulator 4\",\"id\":\"P59646\"},{\"label\":\"FXYD domain-containing ion transport regulator 6\",\"id\":\"Q9H0Q3\"},{\"label\":\"FXYD domain-containing ion transport regulator 7\",\"id\":\"P58549\"},{\"label\":\"Furin\",\"id\":\"P09958\"},{\"label\":\"Glucocorticoid receptor\",\"id\":\"P04150\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Heat shock protein HSP 90-beta\",\"id\":\"P08238\"},{\"label\":\"Histone deacetylase 1\",\"id\":\"Q13547\"},{\"label\":\"Histone deacetylase 2\",\"id\":\"Q92769\"},{\"label\":\"Histone deacetylase complex subunit SAP18\",\"id\":\"O00422\"},{\"label\":\"Histone deacetylase complex subunit SAP30\",\"id\":\"O75446\"},{\"label\":\"Histone deacetylase complex subunit SAP30L\",\"id\":\"Q9HAJ7\"},{\"label\":\"Histone-binding protein RBBP4\",\"id\":\"Q09028\"},{\"label\":\"Histone-binding protein RBBP7\",\"id\":\"Q16576\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant delta\",\"id\":\"P01880\"},{\"label\":\"Immunoglobulin heavy constant mu\",\"id\":\"P01871\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 3-20\",\"id\":\"P01619\"},{\"label\":\"Immunoglobulin kappa variable 3D-20\",\"id\":\"A0A0C4DH25\"},{\"label\":\"Immunoglobulin kappa variable 4-1\",\"id\":\"P06312\"},{\"label\":\"Immunoglobulin kappa variable 5-2\",\"id\":\"P06315\"},{\"label\":\"Immunoglobulin lambda constant 1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 3\",\"id\":\"P0DOY3\"},{\"label\":\"Immunoglobulin lambda constant 6\",\"id\":\"P0CF74\"},{\"label\":\"Immunoglobulin lambda constant 7\",\"id\":\"A0M8Q6\"},{\"label\":\"Immunoglobulin lambda variable 1-40\",\"id\":\"P01703\"},{\"label\":\"Immunoglobulin lambda variable 1-44\",\"id\":\"P01699\"},{\"label\":\"Immunoglobulin lambda variable 1-47\",\"id\":\"P01700\"},{\"label\":\"Immunoglobulin lambda variable 1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 2-8\",\"id\":\"P01709\"},{\"label\":\"Immunoglobulin lambda variable 3-19\",\"id\":\"P01714\"},{\"label\":\"Immunoglobulin lambda variable 3-1\",\"id\":\"P01715\"},{\"label\":\"Immunoglobulin lambda variable 3-21\",\"id\":\"P80748\"},{\"label\":\"Immunoglobulin lambda variable 3-25\",\"id\":\"P01717\"},{\"label\":\"Immunoglobulin lambda variable 3-27\",\"id\":\"P01718\"},{\"label\":\"Immunoglobulin lambda variable 6-57\",\"id\":\"P01721\"},{\"label\":\"Immunoglobulin lambda variable 7-43\",\"id\":\"P04211\"},{\"label\":\"Immunolglobulin kappa light chain variable region L22 (Fragment)\",\"id\":\"A2NXD2\"},{\"label\":\"Inosine-5'-monophosphate dehydrogenase 1\",\"id\":\"P20839\"},{\"label\":\"Inosine-5'-monophosphate dehydrogenase 2\",\"id\":\"P12268\"},{\"label\":\"Integrin alpha-4\",\"id\":\"P13612\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Interferon alpha/beta receptor 1\",\"id\":\"P17181\"},{\"label\":\"Interferon gamma receptor 1\",\"id\":\"P15260\"},{\"label\":\"Interferon gamma receptor 2\",\"id\":\"P38484\"},{\"label\":\"Interleukin-1 receptor type 1\",\"id\":\"P14778\"},{\"label\":\"Interleukin-6 receptor subunit alpha\",\"id\":\"P08887\"},{\"label\":\"Kelch-like ECH-associated protein 1\",\"id\":\"Q14145\"},{\"label\":\"Lysine-specific histone demethylase 1A\",\"id\":\"O60341\"},{\"label\":\"Metastasis-associated protein MTA1\",\"id\":\"Q13330\"},{\"label\":\"Metastasis-associated protein MTA2\",\"id\":\"O94776\"},{\"label\":\"Metastasis-associated protein MTA3\",\"id\":\"Q9BTC8\"},{\"label\":\"Methyl-CpG-binding domain protein 3\",\"id\":\"O95983\"},{\"label\":\"Non-receptor tyrosine-protein kinase TYK2\",\"id\":\"P29597\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"},{\"label\":\"PHD finger protein 21A\",\"id\":\"Q96BD5\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase FKBP1A\",\"id\":\"P62942\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase 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"gtc_id": "[\"\"]" }, { "pathway_label": "Role of ABL in ROBO-SLIT signaling", "protein_name": "[{\"label\":\"Adenylyl cyclase-associated protein 1\",\"id\":\"Q01518\"},{\"label\":\"Adenylyl cyclase-associated protein 2\",\"id\":\"P40123\"},{\"label\":\"CLIP-associating protein 1\",\"id\":\"Q7Z460\"},{\"label\":\"CLIP-associating protein 2\",\"id\":\"O75122\"},{\"label\":\"Roundabout homolog 1\",\"id\":\"Q9Y6N7\"},{\"label\":\"Slit homolog 2 protein\",\"id\":\"O94813\"},{\"label\":\"Tyrosine-protein kinase ABL1\",\"id\":\"P00519\"},{\"label\":\"Tyrosine-protein kinase ABL2\",\"id\":\"P42684\"}]", "uniprot_id": "[\"O75122\",\"O94813\",\"P00519\",\"P40123\",\"P42684\",\"Q01518\",\"Q7Z460\",\"Q9Y6N7\"]", "gene_symbol": "[\"ABL\",\"ABL1\",\"ABL2\",\"ABLL\",\"ARG\",\"CAP\",\"CAP1\",\"CAP2\",\"CLASP1\",\"CLASP2\",\"DUTT1\",\"JTK7\",\"KIAA0622\",\"KIAA0627\",\"MAST1\",\"ROBO1\",\"SLIL3\",\"SLIT2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Sorafenib-resistant KIT mutants", "protein_name": "[{\"label\":\"Mast/stem cell growth factor receptor Kit\",\"id\":\"P10721\"}]", "uniprot_id": "[\"P10721\"]", "gene_symbol": "[\"KIT\",\"SCFR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FGFR3c ligand binding and activation", "protein_name": "[{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Polypeptide N-acetylgalactosaminyltransferase 3\",\"id\":\"Q14435\"}]", "uniprot_id": "[\"O43320\",\"O76093\",\"P05230\",\"P08620\",\"P09038\",\"P31371\",\"Q14435\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": 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1\",\"id\":\"P53985\"},{\"label\":\"Monocarboxylate transporter 3\",\"id\":\"O95907\"},{\"label\":\"Monocarboxylate transporter 4\",\"id\":\"O15427\"},{\"label\":\"Myelin-associated glycoprotein\",\"id\":\"P20916\"},{\"label\":\"Neural cell adhesion molecule L1\",\"id\":\"P32004\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase A\",\"id\":\"P62937\"},{\"label\":\"RING-type E3 ubiquitin-protein ligase PPIL2\",\"id\":\"Q13356\"},{\"label\":\"Sodium/potassium-transporting ATPase subunit beta-1\",\"id\":\"P05026\"},{\"label\":\"Sodium/potassium-transporting ATPase subunit beta-2\",\"id\":\"P14415\"},{\"label\":\"Sodium/potassium-transporting ATPase subunit beta-3\",\"id\":\"P54709\"},{\"label\":\"Y+L amino acid transporter 1\",\"id\":\"Q9UM01\"},{\"label\":\"Y+L amino acid transporter 2\",\"id\":\"Q92536\"},{\"label\":\"b(0,+)-type amino acid transporter 1\",\"id\":\"P82251\"}]", "uniprot_id": 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protein 2\",\"id\":\"Q9UQC2\"},{\"label\":\"IGHV7-81 protein\",\"id\":\"Q6PIL0\"},{\"label\":\"Immunoglobulin heavy constant epsilon\",\"id\":\"P01854\"},{\"label\":\"Immunoglobulin heavy variable 1-2\",\"id\":\"P23083\"},{\"label\":\"Immunoglobulin heavy variable 1-46\",\"id\":\"P01743\"},{\"label\":\"Immunoglobulin heavy variable 1-69\",\"id\":\"P01742\"},{\"label\":\"Immunoglobulin heavy variable 2-5\",\"id\":\"P01817\"},{\"label\":\"Immunoglobulin heavy variable 2-70\",\"id\":\"P01814\"},{\"label\":\"Immunoglobulin heavy variable 3-11\",\"id\":\"P01762\"},{\"label\":\"Immunoglobulin heavy variable 3-13\",\"id\":\"P01766\"},{\"label\":\"Immunoglobulin heavy variable 3-23\",\"id\":\"P01764\"},{\"label\":\"Immunoglobulin heavy variable 3-30\",\"id\":\"P01768\"},{\"label\":\"Immunoglobulin heavy variable 3-33\",\"id\":\"P01772\"},{\"label\":\"Immunoglobulin heavy variable 3-48\",\"id\":\"P01763\"},{\"label\":\"Immunoglobulin heavy variable 3-53\",\"id\":\"P01767\"},{\"label\":\"Immunoglobulin heavy variable 3-7\",\"id\":\"P01780\"},{\"label\":\"Immunoglobulin heavy variable 3-9\",\"id\":\"P01782\"},{\"label\":\"Immunoglobulin heavy variable 4-34\",\"id\":\"P06331\"},{\"label\":\"Immunoglobulin heavy variable 4-39\",\"id\":\"P01824\"},{\"label\":\"Immunoglobulin heavy variable 4-59\",\"id\":\"P01825\"},{\"label\":\"Immunoglobulin kappa constant\",\"id\":\"P01834\"},{\"label\":\"Immunoglobulin kappa variable 1-12\",\"id\":\"A0A0C4DH73\"},{\"label\":\"Immunoglobulin kappa variable 1-16\",\"id\":\"P04430\"},{\"label\":\"Immunoglobulin kappa variable 1-17\",\"id\":\"P01599\"},{\"label\":\"Immunoglobulin kappa variable 1-33\",\"id\":\"P01594\"},{\"label\":\"Immunoglobulin kappa variable 1-39\",\"id\":\"P01597\"},{\"label\":\"Immunoglobulin kappa variable 1-5\",\"id\":\"P01602\"},{\"label\":\"Immunoglobulin kappa variable 1D-12\",\"id\":\"P01611\"},{\"label\":\"Immunoglobulin kappa variable 1D-16\",\"id\":\"P01601\"},{\"label\":\"Immunoglobulin kappa variable 1D-33\",\"id\":\"P01593\"},{\"label\":\"Immunoglobulin kappa variable 1D-39\",\"id\":\"P04432\"},{\"label\":\"Immunoglobulin kappa variable 2-28\",\"id\":\"A0A075B6P5\"},{\"label\":\"Immunoglobulin kappa variable 2-29\",\"id\":\"A2NJV5\"},{\"label\":\"Immunoglobulin kappa variable 2-30\",\"id\":\"P06310\"},{\"label\":\"Immunoglobulin kappa variable 2D-28\",\"id\":\"P01615\"},{\"label\":\"Immunoglobulin kappa variable 2D-30\",\"id\":\"A0A075B6S6\"},{\"label\":\"Immunoglobulin kappa variable 2D-40\",\"id\":\"P01614\"},{\"label\":\"Immunoglobulin kappa variable 3-11\",\"id\":\"P04433\"},{\"label\":\"Immunoglobulin kappa variable 3-15\",\"id\":\"P01624\"},{\"label\":\"Immunoglobulin kappa variable 3-20\",\"id\":\"P01619\"},{\"label\":\"Immunoglobulin kappa variable 3D-20\",\"id\":\"A0A0C4DH25\"},{\"label\":\"Immunoglobulin kappa variable 4-1\",\"id\":\"P06312\"},{\"label\":\"Immunoglobulin kappa variable 5-2\",\"id\":\"P06315\"},{\"label\":\"Immunoglobulin lambda constant 1\",\"id\":\"P0CG04\"},{\"label\":\"Immunoglobulin lambda constant 2\",\"id\":\"P0DOY2\"},{\"label\":\"Immunoglobulin lambda constant 3\",\"id\":\"P0DOY3\"},{\"label\":\"Immunoglobulin lambda constant 6\",\"id\":\"P0CF74\"},{\"label\":\"Immunoglobulin lambda constant 7\",\"id\":\"A0M8Q6\"},{\"label\":\"Immunoglobulin lambda variable 1-40\",\"id\":\"P01703\"},{\"label\":\"Immunoglobulin lambda variable 1-44\",\"id\":\"P01699\"},{\"label\":\"Immunoglobulin lambda variable 1-47\",\"id\":\"P01700\"},{\"label\":\"Immunoglobulin lambda variable 1-51\",\"id\":\"P01701\"},{\"label\":\"Immunoglobulin lambda variable 2-11\",\"id\":\"P01706\"},{\"label\":\"Immunoglobulin lambda variable 2-14\",\"id\":\"P01704\"},{\"label\":\"Immunoglobulin lambda variable 2-23\",\"id\":\"P01705\"},{\"label\":\"Immunoglobulin lambda variable 2-8\",\"id\":\"P01709\"},{\"label\":\"Immunoglobulin lambda variable 3-19\",\"id\":\"P01714\"},{\"label\":\"Immunoglobulin lambda variable 3-1\",\"id\":\"P01715\"},{\"label\":\"Immunoglobulin lambda variable 3-21\",\"id\":\"P80748\"},{\"label\":\"Immunoglobulin lambda variable 3-25\",\"id\":\"P01717\"},{\"label\":\"Immunoglobulin lambda variable 3-27\",\"id\":\"P01718\"},{\"label\":\"Immunoglobulin lambda variable 6-57\",\"id\":\"P01721\"},{\"label\":\"Immunoglobulin lambda variable 7-43\",\"id\":\"P04211\"},{\"label\":\"Immunolglobulin kappa light chain variable region L22 (Fragment)\",\"id\":\"A2NXD2\"},{\"label\":\"Linker for activation of T-cells family member 2\",\"id\":\"Q9GZY6\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform\",\"id\":\"P42338\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein kinase Fyn\",\"id\":\"P06241\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"},{\"label\":\"Tyrosine-protein kinase SYK\",\"id\":\"P43405\"},{\"label\":\"UGa8H (Fragment)\",\"id\":\"A2KUC3\"},{\"label\":\"V1-11 protein (Fragment)\",\"id\":\"Q5NV67\"},{\"label\":\"V1-13 protein (Fragment)\",\"id\":\"Q5NV69\"},{\"label\":\"V1-16 protein (Fragment)\",\"id\":\"Q5NV81\"},{\"label\":\"V1-20 protein (Fragment)\",\"id\":\"Q5NV86\"},{\"label\":\"V1-3 protein (Fragment)\",\"id\":\"Q5NV84\"},{\"label\":\"V1-5 protein (Fragment)\",\"id\":\"Q5NV65\"},{\"label\":\"V1-7 protein (Fragment)\",\"id\":\"Q5NV89\"},{\"label\":\"V1-9 protein (Fragment)\",\"id\":\"Q5NV66\"},{\"label\":\"V2-11 protein (Fragment)\",\"id\":\"Q5NV64\"},{\"label\":\"V2-15 protein (Fragment)\",\"id\":\"Q5NV75\"},{\"label\":\"V2-17 protein (Fragment)\",\"id\":\"Q5NV90\"},{\"label\":\"V2-19 protein (Fragment)\",\"id\":\"Q5NV91\"},{\"label\":\"V2-8 protein (Fragment)\",\"id\":\"Q5NV85\"},{\"label\":\"V3-2 protein (Fragment)\",\"id\":\"Q5NV80\"},{\"label\":\"V3-3 protein (Fragment)\",\"id\":\"Q5NV83\"},{\"label\":\"V3-4 protein (Fragment)\",\"id\":\"Q5NV62\"},{\"label\":\"V4-1 protein (Fragment)\",\"id\":\"Q5NV68\"},{\"label\":\"V4-2 protein (Fragment)\",\"id\":\"Q5NV82\"},{\"label\":\"V4-6 protein (Fragment)\",\"id\":\"Q5NV87\"},{\"label\":\"V5-1 protein (Fragment)\",\"id\":\"Q5NV61\"},{\"label\":\"V5-4 protein (Fragment)\",\"id\":\"Q5NV79\"},{\"label\":\"V5-6 protein (Fragment)\",\"id\":\"Q5NV92\"}]", "uniprot_id": "[\"A0A075B6P5\",\"A0A075B6S6\",\"A0A0C4DH25\",\"A0A0C4DH73\",\"A0M8Q6\",\"A2KUC3\",\"A2NJV5\",\"A2NXD2\",\"O00459\",\"O15530\",\"P01593\",\"P01594\",\"P01597\",\"P01599\",\"P01601\",\"P01602\",\"P01611\",\"P01614\",\"P01615\",\"P01619\",\"P01624\",\"P01699\",\"P01700\",\"P01701\",\"P01703\",\"P01704\",\"P01705\",\"P01706\",\"P01709\",\"P01714\",\"P01715\",\"P01717\",\"P01718\",\"P01721\",\"P01742\",\"P01743\",\"P01762\",\"P01763\",\"P01764\",\"P01766\",\"P01767\",\"P01768\",\"P01772\",\"P01780\",\"P01782\",\"P01814\",\"P01817\",\"P01824\",\"P01825\",\"P01834\",\"P01854\",\"P04211\",\"P04430\",\"P04432\",\"P04433\",\"P06241\",\"P06310\",\"P06312\",\"P06315\",\"P06331\",\"P07948\",\"P0CF74\",\"P0CG04\",\"P0DOY2\",\"P0DOY3\",\"P23083\",\"P27986\",\"P42336\",\"P42338\",\"P43405\",\"P80748\",\"Q07889\",\"Q5NV61\",\"Q5NV62\",\"Q5NV64\",\"Q5NV65\",\"Q5NV66\",\"Q5NV67\",\"Q5NV68\",\"Q5NV69\",\"Q5NV75\",\"Q5NV79\",\"Q5NV80\",\"Q5NV81\",\"Q5NV82\",\"Q5NV83\",\"Q5NV84\",\"Q5NV85\",\"Q5NV86\",\"Q5NV87\",\"Q5NV89\",\"Q5NV90\",\"Q5NV91\",\"Q5NV92\",\"Q6PIL0\",\"Q9GZY6\",\"Q9UQC2\"]", "gene_symbol": "[\"FYN\",\"GAB2\",\"GRB1\",\"IGHE\",\"IGHV\",\"IGHV1-2\",\"IGHV1-46\",\"IGHV1-69\",\"IGHV2-5\",\"IGHV2-70\",\"IGHV3-11\",\"IGHV3-13\",\"IGHV3-23\",\"IGHV3-30\",\"IGHV3-33\",\"IGHV3-48\",\"IGHV3-53\",\"IGHV3-7\",\"IGHV3-9\",\"IGHV4-34\",\"IGHV4-39\",\"IGHV4-59\",\"IGHV7-81\",\"IGKC\",\"IGKV1-12\",\"IGKV1-16\",\"IGKV1-17\",\"IGKV1-33\",\"IGKV1-39\",\"IGKV1-5\",\"IGKV1D-12\",\"IGKV1D-16\",\"IGKV1D-33\",\"IGKV1D-39\",\"IGKV2-28\",\"IGKV2-29\",\"IGKV2-30\",\"IGKV2D-28\",\"IGKV2D-30\",\"IGKV2D-40\",\"IGKV3-11\",\"IGKV3-15\",\"IGKV3-20\",\"IGKV3D-20\",\"IGKV4-1\",\"IGKV5-2\",\"IGLC1\",\"IGLC2\",\"IGLC3\",\"IGLC6\",\"IGLC7\",\"IGLV\",\"IGLV1-40\",\"IGLV1-44\",\"IGLV1-47\",\"IGLV1-51\",\"IGLV2-11\",\"IGLV2-14\",\"IGLV2-23\",\"IGLV2-8\",\"IGLV3-1\",\"IGLV3-19\",\"IGLV3-21\",\"IGLV3-25\",\"IGLV3-27\",\"IGLV6-57\",\"IGLV7-43\",\"JTK8\",\"KIAA0571\",\"LAB\",\"LAT2\",\"LYN\",\"NTAL\",\"PDK1\",\"PDPK1\",\"PIK3C1\",\"PIK3CA\",\"PIK3CB\",\"PIK3R1\",\"PIK3R2\",\"SOS1\",\"SYK\",\"V1-11\",\"V1-13\",\"V1-16\",\"V1-20\",\"V1-3\",\"V1-5\",\"V1-7\",\"V1-9\",\"V2-11\",\"V2-15\",\"V2-17\",\"V2-19\",\"V2-8\",\"V3-2\",\"V3-3\",\"V3-4\",\"V4-1\",\"V4-2\",\"V4-6\",\"V5-1\",\"V5-4\",\"V5-6\",\"WBS15\",\"WBSCR15\",\"WBSCR5\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TRP channels", "protein_name": "[{\"label\":\"Mucolipin-1\",\"id\":\"Q9GZU1\"},{\"label\":\"Mucolipin-2\",\"id\":\"Q8IZK6\"},{\"label\":\"Mucolipin-3\",\"id\":\"Q8TDD5\"},{\"label\":\"Short transient receptor potential channel 1\",\"id\":\"P48995\"},{\"label\":\"Short transient receptor potential channel 3\",\"id\":\"Q13507\"},{\"label\":\"Short transient receptor potential channel 4-associated protein\",\"id\":\"Q8TEL6\"},{\"label\":\"Short transient receptor potential channel 4\",\"id\":\"Q9UBN4\"},{\"label\":\"Short transient receptor potential channel 5\",\"id\":\"Q9UL62\"},{\"label\":\"Short transient receptor potential channel 6\",\"id\":\"Q9Y210\"},{\"label\":\"Short transient receptor potential channel 7\",\"id\":\"Q9HCX4\"},{\"label\":\"Transient receptor potential cation channel subfamily A member 1\",\"id\":\"O75762\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 1\",\"id\":\"Q7Z4N2\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 2\",\"id\":\"O94759\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 3\",\"id\":\"Q9HCF6\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 4\",\"id\":\"Q8TD43\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 5\",\"id\":\"Q9NZQ8\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 6\",\"id\":\"Q9BX84\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 7\",\"id\":\"Q96QT4\"},{\"label\":\"Transient receptor potential cation channel subfamily M member 8\",\"id\":\"Q7Z2W7\"},{\"label\":\"Transient receptor potential cation channel subfamily V member 1\",\"id\":\"Q8NER1\"},{\"label\":\"Transient receptor potential cation channel subfamily V member 2\",\"id\":\"Q9Y5S1\"},{\"label\":\"Transient receptor potential cation channel subfamily V member 3\",\"id\":\"Q8NET8\"},{\"label\":\"Transient receptor potential cation channel subfamily V member 4\",\"id\":\"Q9HBA0\"},{\"label\":\"Transient receptor potential cation channel subfamily V member 5\",\"id\":\"Q9NQA5\"},{\"label\":\"Transient receptor potential cation channel subfamily V member 6\",\"id\":\"Q9H1D0\"}]", "uniprot_id": "[\"O75762\",\"O94759\",\"P48995\",\"Q13507\",\"Q7Z2W7\",\"Q7Z4N2\",\"Q8IZK6\",\"Q8NER1\",\"Q8NET8\",\"Q8TD43\",\"Q8TDD5\",\"Q8TEL6\",\"Q96QT4\",\"Q9BX84\",\"Q9GZU1\",\"Q9H1D0\",\"Q9HBA0\",\"Q9HCF6\",\"Q9HCX4\",\"Q9NQA5\",\"Q9NZQ8\",\"Q9UBN4\",\"Q9UL62\",\"Q9Y210\",\"Q9Y5S1\"]", "gene_symbol": "[\"ANKTM1\",\"C20orf188\",\"CHAK1\",\"CHAK2\",\"ECAC1\",\"ECAC2\",\"EREG1\",\"KIAA1616\",\"KNP3\",\"LTRPC1\",\"LTRPC2\",\"LTRPC3\",\"LTRPC4\",\"LTRPC5\",\"LTRPC6\",\"LTRPC7\",\"MCOLN1\",\"MCOLN2\",\"MCOLN3\",\"ML4\",\"MLSN\",\"MLSN1\",\"MTR1\",\"TRP1\",\"TRP3\",\"TRP5\",\"TRP6\",\"TRP7\",\"TRPA1\",\"TRPC1\",\"TRPC3\",\"TRPC4\",\"TRPC4AP\",\"TRPC5\",\"TRPC6\",\"TRPC7\",\"TRPM1\",\"TRPM2\",\"TRPM3\",\"TRPM4\",\"TRPM5\",\"TRPM6\",\"TRPM7\",\"TRPM8\",\"TRPML1\",\"TRPP8\",\"TRPV1\",\"TRPV2\",\"TRPV3\",\"TRPV4\",\"TRPV5\",\"TRPV6\",\"TRRP4AP\",\"VR1\",\"VRL\",\"VRL2\",\"VROAC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of NOXA and translocation to mitochondria", "protein_name": "[{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Phorbol-12-myristate-13-acetate-induced protein 1\",\"id\":\"Q13794\"},{\"label\":\"Transcription factor Dp-1\",\"id\":\"Q14186\"},{\"label\":\"Transcription factor Dp-2\",\"id\":\"Q14188\"},{\"label\":\"Transcription factor E2F1\",\"id\":\"Q01094\"}]", "uniprot_id": "[\"P04637\",\"Q01094\",\"Q13794\",\"Q14186\",\"Q14188\"]", "gene_symbol": "[\"DP1\",\"DP2\",\"E2F1\",\"NOXA\",\"P53\",\"PMAIP1\",\"RBBP3\",\"TFDP1\",\"TFDP2\",\"TP53\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Reduction of cytosolic Ca++ levels", "protein_name": "[{\"label\":\"Calmodulin-1\",\"id\":\"P0DP23\"},{\"label\":\"Plasma membrane calcium-transporting ATPase 1\",\"id\":\"P20020\"},{\"label\":\"Plasma membrane calcium-transporting ATPase 2\",\"id\":\"Q01814\"},{\"label\":\"Plasma membrane calcium-transporting ATPase 3\",\"id\":\"Q16720\"},{\"label\":\"Plasma membrane calcium-transporting ATPase 4\",\"id\":\"P23634\"},{\"label\":\"Sarcoplasmic/endoplasmic reticulum calcium ATPase 1\",\"id\":\"O14983\"},{\"label\":\"Sarcoplasmic/endoplasmic reticulum calcium ATPase 2\",\"id\":\"P16615\"},{\"label\":\"Sarcoplasmic/endoplasmic reticulum calcium ATPase 3\",\"id\":\"Q93084\"},{\"label\":\"Sodium/calcium exchanger 1\",\"id\":\"P32418\"},{\"label\":\"Sodium/calcium exchanger 2\",\"id\":\"Q9UPR5\"},{\"label\":\"Sodium/calcium exchanger 3\",\"id\":\"P57103\"},{\"label\":\"Sorcin\",\"id\":\"P30626\"}]", "uniprot_id": "[\"O14983\",\"P0DP23\",\"P16615\",\"P20020\",\"P23634\",\"P30626\",\"P32418\",\"P57103\",\"Q01814\",\"Q16720\",\"Q93084\",\"Q9UPR5\"]", "gene_symbol": "[\"ATP2A1\",\"ATP2A2\",\"ATP2A3\",\"ATP2B\",\"ATP2B1\",\"ATP2B2\",\"ATP2B3\",\"ATP2B4\",\"CALM\",\"CALM1\",\"CAM\",\"CAM1\",\"CNC\",\"KIAA1087\",\"MXRA1\",\"NCX1\",\"NCX2\",\"NCX3\",\"PMCA1\",\"PMCA2\",\"SLC8A1\",\"SLC8A2\",\"SLC8A3\",\"SRI\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCG5 causes sitosterolemia", "protein_name": "[{\"label\":\"ATP-binding cassette sub-family G member 5\",\"id\":\"Q9H222\"},{\"label\":\"ATP-binding cassette sub-family G member 8\",\"id\":\"Q9H221\"}]", "uniprot_id": "[\"Q9H221\",\"Q9H222\"]", "gene_symbol": "[\"ABCG5\",\"ABCG8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective GALK1 causes GALCT2", "protein_name": "[{\"label\":\"Galactokinase\",\"id\":\"P51570\"}]", "uniprot_id": "[\"P51570\"]", "gene_symbol": "[\"GALK\",\"GALK1\"]", "gtc_id": "[\"G93924TT\"]" }, { "pathway_label": "SHC1 events in ERBB4 signaling", "protein_name": "[{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O14511\",\"O14944\",\"P01111\",\"P01112\",\"P29353\",\"P35070\",\"P56975\",\"Q02297\",\"Q07889\",\"Q8WWG1\",\"Q99075\"]", "gene_symbol": "[\"BTC\",\"DTR\",\"DTS\",\"EREG\",\"GGF\",\"HBEGF\",\"HEGFL\",\"HGL\",\"HRAS\",\"HRAS1\",\"HRGA\",\"NDF\",\"NRAS\",\"NRG1\",\"NRG2\",\"NRG3\",\"NRG4\",\"NTAK\",\"SHC\",\"SHC1\",\"SHCA\",\"SMDF\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)", "protein_name": "[{\"label\":\"Potassium channel subfamily K member 1\",\"id\":\"O00180\"},{\"label\":\"Potassium channel subfamily K member 6\",\"id\":\"Q9Y257\"},{\"label\":\"Potassium channel subfamily K member 7\",\"id\":\"Q9Y2U2\"}]", "uniprot_id": "[\"O00180\",\"Q9Y257\",\"Q9Y2U2\"]", "gene_symbol": "[\"HOHO1\",\"KCNK1\",\"KCNK6\",\"KCNK7\",\"KCNO1\",\"TOSS\",\"TWIK1\",\"TWIK2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Loss of proteins required for interphase microtubule organization from the centrosome", "protein_name": "[{\"label\":\"14-3-3 protein epsilon\",\"id\":\"P62258\"},{\"label\":\"14-3-3 protein gamma\",\"id\":\"P61981\"},{\"label\":\"A-kinase anchor protein 9\",\"id\":\"Q99996\"},{\"label\":\"Alpha-centractin\",\"id\":\"P61163\"},{\"label\":\"CDK5 regulatory subunit-associated protein 2\",\"id\":\"Q96SN8\"},{\"label\":\"CLIP-associating protein 1\",\"id\":\"Q7Z460\"},{\"label\":\"Casein kinase I isoform delta\",\"id\":\"P48730\"},{\"label\":\"Casein kinase I isoform epsilon\",\"id\":\"P49674\"},{\"label\":\"Centrin-2\",\"id\":\"P41208\"},{\"label\":\"Centriolar coiled-coil protein of 110 kDa\",\"id\":\"O43303\"},{\"label\":\"Centriole and centriolar satellite protein OFD1\",\"id\":\"O75665\"},{\"label\":\"Centriolin\",\"id\":\"Q7Z7A1\"},{\"label\":\"Centromere protein J\",\"id\":\"Q9HC77\"},{\"label\":\"Centrosomal protein 43\",\"id\":\"O95684\"},{\"label\":\"Centrosomal protein of 131 kDa\",\"id\":\"Q9UPN4\"},{\"label\":\"Centrosomal protein of 135 kDa\",\"id\":\"Q66GS9\"},{\"label\":\"Centrosomal protein of 152 kDa\",\"id\":\"O94986\"},{\"label\":\"Centrosomal protein of 164 kDa\",\"id\":\"Q9UPV0\"},{\"label\":\"Centrosomal protein of 192 kDa\",\"id\":\"Q8TEP8\"},{\"label\":\"Centrosomal protein of 290 kDa\",\"id\":\"O15078\"},{\"label\":\"Centrosomal protein of 41 kDa\",\"id\":\"Q9BYV8\"},{\"label\":\"Centrosomal protein of 57 kDa\",\"id\":\"Q86XR8\"},{\"label\":\"Centrosomal protein of 63 kDa\",\"id\":\"Q96MT8\"},{\"label\":\"Centrosomal protein of 70 kDa\",\"id\":\"Q8NHQ1\"},{\"label\":\"Centrosomal protein of 72 kDa\",\"id\":\"Q9P209\"},{\"label\":\"Centrosomal protein of 76 kDa\",\"id\":\"Q8TAP6\"},{\"label\":\"Centrosomal protein of 78 kDa\",\"id\":\"Q5JTW2\"},{\"label\":\"Centrosome-associated protein ALMS1\",\"id\":\"Q8TCU4\"},{\"label\":\"Centrosome-associated protein CEP250\",\"id\":\"Q9BV73\"},{\"label\":\"Cyclin-dependent kinase 1\",\"id\":\"P06493\"},{\"label\":\"Cytoplasmic dynein 1 heavy chain 1\",\"id\":\"Q14204\"},{\"label\":\"Cytoplasmic dynein 1 intermediate chain 2\",\"id\":\"Q13409\"},{\"label\":\"Cytoskeleton-associated protein 5\",\"id\":\"Q14008\"},{\"label\":\"Dynactin subunit 2\",\"id\":\"Q13561\"},{\"label\":\"Dynactin subunit 3\",\"id\":\"O75935\"},{\"label\":\"Dynein light chain 1, cytoplasmic\",\"id\":\"P63167\"},{\"label\":\"HAUS augmin-like complex subunit 1\",\"id\":\"Q96CS2\"},{\"label\":\"HAUS augmin-like complex subunit 2\",\"id\":\"Q9NVX0\"},{\"label\":\"HAUS augmin-like complex subunit 3\",\"id\":\"Q68CZ6\"},{\"label\":\"HAUS augmin-like complex subunit 4\",\"id\":\"Q9H6D7\"},{\"label\":\"HAUS augmin-like complex subunit 5\",\"id\":\"O94927\"},{\"label\":\"HAUS augmin-like complex subunit 6\",\"id\":\"Q7Z4H7\"},{\"label\":\"HAUS augmin-like complex subunit 7\",\"id\":\"Q99871\"},{\"label\":\"HAUS augmin-like complex subunit 8\",\"id\":\"Q9BT25\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Microtubule nucleation factor SSNA1\",\"id\":\"O43805\"},{\"label\":\"Microtubule-associated protein RP/EB family member 1\",\"id\":\"Q15691\"},{\"label\":\"Ninein-like protein\",\"id\":\"Q9Y2I6\"},{\"label\":\"Nuclear distribution protein nudE homolog 1\",\"id\":\"Q9NXR1\"},{\"label\":\"Outer dense fiber protein 2\",\"id\":\"Q5BJF6\"},{\"label\":\"Pericentrin\",\"id\":\"O95613\"},{\"label\":\"Pericentriolar material 1 protein\",\"id\":\"Q15154\"},{\"label\":\"Platelet-activating factor acetylhydrolase IB subunit beta\",\"id\":\"P43034\"},{\"label\":\"Protein NEDD1\",\"id\":\"Q8NHV4\"},{\"label\":\"Protein SFI1 homolog\",\"id\":\"A8K8P3\"},{\"label\":\"Serine/threonine-protein kinase Nek2\",\"id\":\"P51955\"},{\"label\":\"Serine/threonine-protein kinase PLK1\",\"id\":\"P53350\"},{\"label\":\"Serine/threonine-protein kinase PLK4\",\"id\":\"O00444\"},{\"label\":\"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform\",\"id\":\"P30153\"},{\"label\":\"Serologically defined colon cancer antigen 8\",\"id\":\"Q86SQ7\"},{\"label\":\"Tubulin alpha-1A chain\",\"id\":\"Q71U36\"},{\"label\":\"Tubulin alpha-4A chain\",\"id\":\"P68366\"},{\"label\":\"Tubulin beta chain\",\"id\":\"P07437\"},{\"label\":\"Tubulin beta-4A chain\",\"id\":\"P04350\"},{\"label\":\"Tubulin beta-4B chain\",\"id\":\"P68371\"},{\"label\":\"Tubulin gamma-1 chain\",\"id\":\"P23258\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase type II-beta regulatory subunit\",\"id\":\"P31323\"}]", "uniprot_id": 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beta\",\"id\":\"O14986\"},{\"label\":\"Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma\",\"id\":\"O60331\"},{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha\",\"id\":\"P48426\"},{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 beta\",\"id\":\"P78356\"},{\"label\":\"Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma\",\"id\":\"Q8TBX8\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14\",\"id\":\"Q8NCE2\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2\",\"id\":\"Q13614\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3\",\"id\":\"Q13615\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6\",\"id\":\"Q9Y217\"},{\"label\":\"Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8\",\"id\":\"Q96EF0\"},{\"label\":\"Phosphatidylinositol-3-phosphate phosphatase MTMR1\",\"id\":\"Q13613\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 5\",\"id\":\"Q8WYR1\"},{\"label\":\"Phosphoinositide 3-kinase regulatory subunit 6\",\"id\":\"Q5UE93\"},{\"label\":\"Pleckstrin homology domain-containing family A member 1\",\"id\":\"Q9HB21\"},{\"label\":\"Pleckstrin homology domain-containing family A member 2\",\"id\":\"Q9HB19\"},{\"label\":\"Pleckstrin homology domain-containing family A member 3\",\"id\":\"Q9HB20\"},{\"label\":\"Pleckstrin homology domain-containing family A member 4\",\"id\":\"Q9H4M7\"},{\"label\":\"Pleckstrin homology domain-containing family A member 5\",\"id\":\"Q9HAU0\"},{\"label\":\"Pleckstrin homology domain-containing family A member 6\",\"id\":\"Q9Y2H5\"},{\"label\":\"Pleckstrin homology domain-containing family A member 8\",\"id\":\"Q96JA3\"},{\"label\":\"RUN and FYVE domain-containing protein 1\",\"id\":\"Q96T51\"},{\"label\":\"Ras-related protein Rab-14\",\"id\":\"P61106\"},{\"label\":\"Ras-related protein Rab-4A\",\"id\":\"P20338\"},{\"label\":\"Ras-related protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Sperm Motility And Taxes", "protein_name": "[{\"label\":\"Cation channel sperm-associated auxiliary subunit beta\",\"id\":\"Q9H7T0\"},{\"label\":\"Cation channel sperm-associated auxiliary subunit delta\",\"id\":\"Q86XM0\"},{\"label\":\"Cation channel sperm-associated auxiliary subunit gamma\",\"id\":\"Q6ZRH7\"},{\"label\":\"Cation channel sperm-associated protein 1\",\"id\":\"Q8NEC5\"},{\"label\":\"Cation channel sperm-associated protein 2\",\"id\":\"Q96P56\"},{\"label\":\"Cation channel sperm-associated protein 3\",\"id\":\"Q86XQ3\"},{\"label\":\"Cation channel sperm-associated protein 4\",\"id\":\"Q7RTX7\"},{\"label\":\"Potassium channel subfamily U member 1\",\"id\":\"A8MYU2\"},{\"label\":\"Voltage-gated hydrogen channel 1\",\"id\":\"Q96D96\"}]", "uniprot_id": "[\"A8MYU2\",\"Q6ZRH7\",\"Q7RTX7\",\"Q86XM0\",\"Q86XQ3\",\"Q8NEC5\",\"Q96D96\",\"Q96P56\",\"Q9H7T0\"]", "gene_symbol": "[\"C14orf161\",\"C19orf15\",\"CATSPER1\",\"CATSPER2\",\"CATSPER3\",\"CATSPER4\",\"CATSPERB\",\"CATSPERD\",\"CATSPERG\",\"HVCN1\",\"KCNMA3\",\"KCNMC1\",\"KCNU1\",\"SLO3\",\"TMEM146\",\"VSOP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "pexidartinib-resistant FLT3 mutants", "protein_name": "[{\"label\":\"Receptor-type tyrosine-protein kinase FLT3\",\"id\":\"P36888\"}]", "uniprot_id": "[\"P36888\"]", "gene_symbol": "[\"CD135\",\"FLK2\",\"FLT3\",\"STK1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "tRNA processing in the nucleus", "protein_name": "[{\"label\":\"ATP-dependent RNA helicase DDX1\",\"id\":\"Q92499\"},{\"label\":\"Aladin\",\"id\":\"Q9NRG9\"},{\"label\":\"Ashwin\",\"id\":\"Q9BVC5\"},{\"label\":\"CCA tRNA nucleotidyltransferase 1, mitochondrial\",\"id\":\"Q96Q11\"},{\"label\":\"Cleavage and polyadenylation specificity factor subunit 1\",\"id\":\"Q10570\"},{\"label\":\"Cleavage and polyadenylation specificity factor subunit 4\",\"id\":\"O95639\"},{\"label\":\"Cleavage stimulation factor subunit 2\",\"id\":\"P33240\"},{\"label\":\"E3 SUMO-protein ligase RanBP2\",\"id\":\"P49792\"},{\"label\":\"Exportin-T\",\"id\":\"O43592\"},{\"label\":\"GTP-binding nuclear protein Ran\",\"id\":\"P62826\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121\",\"id\":\"Q96HA1\"},{\"label\":\"Nuclear envelope pore membrane protein POM 121C\",\"id\":\"A8CG34\"},{\"label\":\"Nuclear pore complex protein Nup107\",\"id\":\"P57740\"},{\"label\":\"Nuclear pore complex protein Nup133\",\"id\":\"Q8WUM0\"},{\"label\":\"Nuclear pore complex protein Nup153\",\"id\":\"P49790\"},{\"label\":\"Nuclear pore complex protein Nup155\",\"id\":\"O75694\"},{\"label\":\"Nuclear pore complex protein Nup160\",\"id\":\"Q12769\"},{\"label\":\"Nuclear pore complex protein Nup205\",\"id\":\"Q92621\"},{\"label\":\"Nuclear pore complex protein Nup214\",\"id\":\"P35658\"},{\"label\":\"Nuclear pore complex protein Nup50\",\"id\":\"Q9UKX7\"},{\"label\":\"Nuclear pore complex protein Nup85\",\"id\":\"Q9BW27\"},{\"label\":\"Nuclear pore complex protein Nup88\",\"id\":\"Q99567\"},{\"label\":\"Nuclear pore complex protein Nup93\",\"id\":\"Q8N1F7\"},{\"label\":\"Nuclear pore glycoprotein p62\",\"id\":\"P37198\"},{\"label\":\"Nuclear pore membrane glycoprotein 210\",\"id\":\"Q8TEM1\"},{\"label\":\"Nucleoporin NDC1\",\"id\":\"Q9BTX1\"},{\"label\":\"Nucleoporin NUP188\",\"id\":\"Q5SRE5\"},{\"label\":\"Nucleoporin NUP35\",\"id\":\"Q8NFH5\"},{\"label\":\"Nucleoporin NUP42\",\"id\":\"O15504\"},{\"label\":\"Nucleoporin Nup37\",\"id\":\"Q8NFH4\"},{\"label\":\"Nucleoporin Nup43\",\"id\":\"Q8NFH3\"},{\"label\":\"Nucleoporin p54\",\"id\":\"Q7Z3B4\"},{\"label\":\"Nucleoprotein TPR\",\"id\":\"P12270\"},{\"label\":\"Polyribonucleotide 5'-hydroxyl-kinase Clp1\",\"id\":\"Q92989\"},{\"label\":\"Protein FAM98B\",\"id\":\"Q52LJ0\"},{\"label\":\"Protein SEC13 homolog\",\"id\":\"P55735\"},{\"label\":\"Protein archease\",\"id\":\"Q8IWT0\"},{\"label\":\"RNA transcription, translation and transport factor protein\",\"id\":\"Q9Y224\"},{\"label\":\"RNA-splicing ligase RtcB homolog\",\"id\":\"Q9Y3I0\"},{\"label\":\"Ribonuclease P protein subunit p14\",\"id\":\"O95059\"},{\"label\":\"Ribonuclease P protein subunit p20\",\"id\":\"O75817\"},{\"label\":\"Ribonuclease P protein subunit p21\",\"id\":\"Q9H633\"},{\"label\":\"Ribonuclease P protein subunit p25\",\"id\":\"Q9BUL9\"},{\"label\":\"Ribonuclease P protein subunit p29\",\"id\":\"O95707\"},{\"label\":\"Ribonuclease P protein subunit p30\",\"id\":\"P78346\"},{\"label\":\"Ribonuclease P protein subunit p38\",\"id\":\"P78345\"},{\"label\":\"Ribonuclease P protein subunit p40\",\"id\":\"O75818\"},{\"label\":\"Ribonuclease P/MRP protein subunit POP5\",\"id\":\"Q969H6\"},{\"label\":\"Ribonucleases P/MRP protein subunit POP1\",\"id\":\"Q99575\"},{\"label\":\"Zinc phosphodiesterase ELAC protein 2\",\"id\":\"Q9BQ52\"},{\"label\":\"mRNA export factor RAE1\",\"id\":\"P78406\"},{\"label\":\"tRNA-splicing endonuclease subunit Sen15\",\"id\":\"Q8WW01\"},{\"label\":\"tRNA-splicing endonuclease subunit Sen2\",\"id\":\"Q8NCE0\"},{\"label\":\"tRNA-splicing endonuclease subunit Sen34\",\"id\":\"Q9BSV6\"},{\"label\":\"tRNA-splicing endonuclease subunit Sen54\",\"id\":\"Q7Z6J9\"}]", "uniprot_id": "[\"A8CG34\",\"O15504\",\"O43592\",\"O75694\",\"O75817\",\"O75818\",\"O95059\",\"O95639\",\"O95707\",\"P12270\",\"P33240\",\"P35658\",\"P37198\",\"P49790\",\"P49792\",\"P55735\",\"P57740\",\"P62826\",\"P78345\",\"P78346\",\"P78406\",\"Q10570\",\"Q12769\",\"Q52LJ0\",\"Q5SRE5\",\"Q7Z3B4\",\"Q7Z6J9\",\"Q8IWT0\",\"Q8N1F7\",\"Q8NCE0\",\"Q8NFH3\",\"Q8NFH4\",\"Q8NFH5\",\"Q8TEM1\",\"Q8WUM0\",\"Q8WW01\",\"Q92499\",\"Q92621\",\"Q92989\",\"Q969H6\",\"Q96HA1\",\"Q96Q11\",\"Q99567\",\"Q99575\",\"Q9BQ52\",\"Q9BSV6\",\"Q9BTX1\",\"Q9BUL9\",\"Q9BVC5\",\"Q9BW27\",\"Q9H633\",\"Q9NRG9\",\"Q9UKX7\",\"Q9Y224\",\"Q9Y3I0\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "RIPK1-mediated regulated necrosis", "protein_name": "[{\"label\":\"Baculoviral IAP repeat-containing protein 2\",\"id\":\"Q13490\"},{\"label\":\"Baculoviral IAP repeat-containing protein 3\",\"id\":\"Q13489\"},{\"label\":\"Caspase-8\",\"id\":\"Q14790\"},{\"label\":\"E3 ubiquitin-protein ligase CHIP\",\"id\":\"Q9UNE7\"},{\"label\":\"E3 ubiquitin-protein ligase XIAP\",\"id\":\"P98170\"},{\"label\":\"FAS-associated death domain protein\",\"id\":\"Q13158\"},{\"label\":\"Flotillin-1\",\"id\":\"O75955\"},{\"label\":\"Flotillin-2\",\"id\":\"Q14254\"},{\"label\":\"Mixed lineage kinase domain-like protein\",\"id\":\"Q8NB16\"},{\"label\":\"Non-structural protein 1\",\"id\":\"P03496\"},{\"label\":\"Programmed cell death 6-interacting protein\",\"id\":\"Q8WUM4\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 1\",\"id\":\"Q13546\"},{\"label\":\"Receptor-interacting serine/threonine-protein kinase 3\",\"id\":\"Q9Y572\"},{\"label\":\"Ribonucleoside-diphosphate reductase large subunit\",\"id\":\"P08543\"},{\"label\":\"Syntenin-1\",\"id\":\"O00560\"},{\"label\":\"TNF receptor-associated factor 2\",\"id\":\"Q12933\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 10\",\"id\":\"P50591\"},{\"label\":\"Tumor necrosis factor ligand superfamily member 6\",\"id\":\"P48023\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10A\",\"id\":\"O00220\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 10B\",\"id\":\"O14763\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 6\",\"id\":\"P25445\"},{\"label\":\"Tumor necrosis factor receptor type 1-associated DEATH domain protein\",\"id\":\"Q15628\"},{\"label\":\"UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit\",\"id\":\"O15294\"}]", "uniprot_id": 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"protein_name": "[{\"label\":\"Cadherin-19\",\"id\":\"Q9H159\"},{\"label\":\"Catenin alpha-1\",\"id\":\"P35221\"},{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Catenin delta-1\",\"id\":\"O60716\"},{\"label\":\"Endoribonuclease ZC3H12A\",\"id\":\"Q5D1E8\"},{\"label\":\"Junction plakoglobin\",\"id\":\"P14923\"},{\"label\":\"Transcription factor SOX-10\",\"id\":\"P56693\"}]", "uniprot_id": "[\"O60716\",\"P14923\",\"P35221\",\"P35222\",\"P56693\",\"Q5D1E8\",\"Q9H159\"]", "gene_symbol": "[\"CDH19\",\"CDH7L2\",\"CTNNA1\",\"CTNNB\",\"CTNNB1\",\"CTNND1\",\"CTNNG\",\"DP3\",\"JUP\",\"KIAA0384\",\"MCPIP\",\"MCPIP1\",\"SOX10\",\"ZC3H12A\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "protein_name": "[{\"label\":\"AT-rich interactive domain-containing protein 1A\",\"id\":\"O14497\"},{\"label\":\"AT-rich interactive domain-containing protein 1B\",\"id\":\"Q8NFD5\"},{\"label\":\"AT-rich interactive 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2\",\"id\":\"Q9H2X6\"},{\"label\":\"Polycomb complex protein BMI-1\",\"id\":\"P35226\"},{\"label\":\"Polycomb group RING finger protein 5\",\"id\":\"Q86SE9\"},{\"label\":\"Polyhomeotic-like protein 1\",\"id\":\"P78364\"},{\"label\":\"Polyhomeotic-like protein 2\",\"id\":\"Q8IXK0\"},{\"label\":\"Polyhomeotic-like protein 3\",\"id\":\"Q8NDX5\"},{\"label\":\"Probable global transcription activator SNF2L2\",\"id\":\"P51531\"},{\"label\":\"Protein polybromo-1\",\"id\":\"Q86U86\"},{\"label\":\"RING1 and YY1-binding protein\",\"id\":\"Q8N488\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"},{\"label\":\"SWI/SNF complex subunit SMARCC1\",\"id\":\"Q92922\"},{\"label\":\"SWI/SNF complex subunit SMARCC2\",\"id\":\"Q8TAQ2\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1\",\"id\":\"Q12824\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1\",\"id\":\"Q96GM5\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2\",\"id\":\"Q92925\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3\",\"id\":\"Q6STE5\"},{\"label\":\"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1\",\"id\":\"Q969G3\"},{\"label\":\"Transcription activator BRG1\",\"id\":\"P51532\"},{\"label\":\"YY1-associated factor 2\",\"id\":\"Q8IY57\"}]", "uniprot_id": "[\"O00257\",\"O14497\",\"O94805\",\"O95503\",\"O96019\",\"P19784\",\"P35226\",\"P51531\",\"P51532\",\"P67870\",\"P68400\",\"P78364\",\"Q01196\",\"Q06587\",\"Q09472\",\"Q12824\",\"Q13951\",\"Q14781\",\"Q68CP9\",\"Q6STE5\",\"Q86SE9\",\"Q86U86\",\"Q8IXK0\",\"Q8IY57\",\"Q8N488\",\"Q8NDX5\",\"Q8NFD5\",\"Q8TAQ2\",\"Q8WXX7\",\"Q92922\",\"Q92925\",\"Q969G3\",\"Q96GM5\",\"Q99496\",\"Q9H2X6\",\"Q9HC52\"]", "gene_symbol": 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"gtc_id": "[\"\"]" }, { "pathway_label": "RAC1 GTPase cycle", "protein_name": "[{\"label\":\"ARF GTPase-activating protein GIT1\",\"id\":\"Q9Y2X7\"},{\"label\":\"ARF GTPase-activating protein GIT2\",\"id\":\"Q14161\"},{\"label\":\"Abl interactor 1\",\"id\":\"Q8IZP0\"},{\"label\":\"Abl interactor 2\",\"id\":\"Q9NYB9\"},{\"label\":\"Actin nucleation-promoting factor WAS\",\"id\":\"P42768\"},{\"label\":\"Actin nucleation-promoting factor WASL\",\"id\":\"O00401\"},{\"label\":\"Actin remodeling regulator NHS\",\"id\":\"Q6T4R5\"},{\"label\":\"Actin-binding protein WASF1\",\"id\":\"Q92558\"},{\"label\":\"Actin-binding protein WASF2\",\"id\":\"Q9Y6W5\"},{\"label\":\"Actin-binding protein WASF3\",\"id\":\"Q9UPY6\"},{\"label\":\"Active breakpoint cluster region-related protein\",\"id\":\"Q12979\"},{\"label\":\"Alsin\",\"id\":\"Q96Q42\"},{\"label\":\"Amphoterin-induced protein 2\",\"id\":\"Q86SJ2\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1\",\"id\":\"Q96P48\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2\",\"id\":\"Q8WZ64\"},{\"label\":\"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3\",\"id\":\"Q8WWN8\"},{\"label\":\"BAR/IMD domain-containing adapter protein 2-like 1\",\"id\":\"Q9UHR4\"},{\"label\":\"BAR/IMD domain-containing adapter protein 2\",\"id\":\"Q9UQB8\"},{\"label\":\"Beta-chimaerin\",\"id\":\"P52757\"},{\"label\":\"Breakpoint cluster region protein\",\"id\":\"P11274\"},{\"label\":\"Caveolin-1\",\"id\":\"Q03135\"},{\"label\":\"Cdc42 effector protein 1\",\"id\":\"Q00587\"},{\"label\":\"Cdc42 effector protein 4\",\"id\":\"Q9H3Q1\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Cell surface glycoprotein MUC18\",\"id\":\"P43121\"},{\"label\":\"Citron Rho-interacting kinase\",\"id\":\"O14578\"},{\"label\":\"Cytochrome b-245 heavy chain\",\"id\":\"P04839\"},{\"label\":\"Cytochrome b-245 light chain\",\"id\":\"P13498\"},{\"label\":\"Cytoplasmic FMR1-interacting protein 1\",\"id\":\"Q7L576\"},{\"label\":\"Cytoplasmic FMR1-interacting protein 2\",\"id\":\"Q96F07\"},{\"label\":\"DEP domain-containing protein 1B\",\"id\":\"Q8WUY9\"},{\"label\":\"Dedicator of cytokinesis protein 10\",\"id\":\"Q96BY6\"},{\"label\":\"Dedicator of cytokinesis protein 11\",\"id\":\"Q5JSL3\"},{\"label\":\"Dedicator of cytokinesis protein 1\",\"id\":\"Q14185\"},{\"label\":\"Dedicator of cytokinesis protein 2\",\"id\":\"Q92608\"},{\"label\":\"Dedicator of cytokinesis protein 3\",\"id\":\"Q8IZD9\"},{\"label\":\"Dedicator of cytokinesis protein 4\",\"id\":\"Q8N1I0\"},{\"label\":\"Dedicator of cytokinesis protein 5\",\"id\":\"Q9H7D0\"},{\"label\":\"Dedicator of cytokinesis protein 6\",\"id\":\"Q96HP0\"},{\"label\":\"Dedicator of cytokinesis protein 7\",\"id\":\"Q96N67\"},{\"label\":\"Dedicator of cytokinesis protein 8\",\"id\":\"Q8NF50\"},{\"label\":\"Dedicator of cytokinesis protein 9\",\"id\":\"Q9BZ29\"},{\"label\":\"Delta(14)-sterol reductase LBR\",\"id\":\"Q14739\"},{\"label\":\"Differentially expressed in FDCP 6 homolog\",\"id\":\"Q9H4E7\"},{\"label\":\"Emerin\",\"id\":\"P50402\"},{\"label\":\"Ephexin-1\",\"id\":\"Q8N5V2\"},{\"label\":\"Ephrin type-A receptor 2\",\"id\":\"P29317\"},{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Extended synaptotagmin-1\",\"id\":\"Q9BSJ8\"},{\"label\":\"FERM, ARHGEF and pleckstrin domain-containing protein 1\",\"id\":\"Q9Y4F1\"},{\"label\":\"FERM, ARHGEF and pleckstrin domain-containing protein 2\",\"id\":\"O94887\"},{\"label\":\"FYVE, RhoGEF and PH domain-containing protein 5\",\"id\":\"Q6ZNL6\"},{\"label\":\"Fermitin family homolog 2\",\"id\":\"Q96AC1\"},{\"label\":\"Formin-like protein 1\",\"id\":\"O95466\"},{\"label\":\"GEM-interacting protein\",\"id\":\"Q9P107\"},{\"label\":\"Granule associated Rac and RHOG effector protein 1\",\"id\":\"O15063\"},{\"label\":\"Guanine nucleotide exchange factor DBS\",\"id\":\"O15068\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Guanine nucleotide exchange factor VAV3\",\"id\":\"Q9UKW4\"},{\"label\":\"Guanine nucleotide-binding protein subunit alpha-13\",\"id\":\"Q14344\"},{\"label\":\"Inner nuclear membrane protein Man1\",\"id\":\"Q9Y2U8\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Kalirin\",\"id\":\"O60229\"},{\"label\":\"Kinectin\",\"id\":\"Q86UP2\"},{\"label\":\"Lamina-associated polypeptide 2, isoforms beta/gamma\",\"id\":\"P42167\"},{\"label\":\"MAGUK p55 subfamily member 7\",\"id\":\"Q5T2T1\"},{\"label\":\"N-chimaerin\",\"id\":\"P15882\"},{\"label\":\"NADPH oxidase 1\",\"id\":\"Q9Y5S8\"},{\"label\":\"NADPH oxidase 3\",\"id\":\"Q9HBY0\"},{\"label\":\"NADPH oxidase activator 1\",\"id\":\"Q86UR1\"},{\"label\":\"NADPH oxidase organizer 1\",\"id\":\"Q8NFA2\"},{\"label\":\"Nck-associated protein 1-like\",\"id\":\"P55160\"},{\"label\":\"Nck-associated protein 1\",\"id\":\"Q9Y2A7\"},{\"label\":\"Neutral amino acid transporter B(0)\",\"id\":\"Q15758\"},{\"label\":\"Neutrophil cytosol factor 1\",\"id\":\"P14598\"},{\"label\":\"Neutrophil cytosol factor 2\",\"id\":\"P19878\"},{\"label\":\"Neutrophil cytosol factor 4\",\"id\":\"Q15080\"},{\"label\":\"Nischarin\",\"id\":\"Q9Y2I1\"},{\"label\":\"Oligophrenin-1\",\"id\":\"O60890\"},{\"label\":\"Partitioning defective 6 homolog alpha\",\"id\":\"Q9NPB6\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein\",\"id\":\"Q8TCU6\"},{\"label\":\"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein\",\"id\":\"Q70Z35\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Phospholipase D1\",\"id\":\"Q13393\"},{\"label\":\"Phospholipase D2\",\"id\":\"O14939\"},{\"label\":\"Pleckstrin homology domain-containing family G member 1\",\"id\":\"Q9ULL1\"},{\"label\":\"Pleckstrin homology domain-containing family G member 2\",\"id\":\"Q9H7P9\"},{\"label\":\"Pleckstrin homology domain-containing family G member 3\",\"id\":\"A1L390\"},{\"label\":\"Pleckstrin homology domain-containing family G member 6\",\"id\":\"Q3KR16\"},{\"label\":\"Protein BRICK1\",\"id\":\"Q8WUW1\"},{\"label\":\"Protein ECT2\",\"id\":\"Q9H8V3\"},{\"label\":\"Protein FAM13A\",\"id\":\"O94988\"},{\"label\":\"Protein FAM13B\",\"id\":\"Q9NYF5\"},{\"label\":\"Protein diaphanous homolog 3\",\"id\":\"Q9NSV4\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"Puratrophin-1\",\"id\":\"Q58EX7\"},{\"label\":\"Rac 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protein 17\",\"id\":\"Q68EM7\"},{\"label\":\"Rho GTPase-activating protein 1\",\"id\":\"Q07960\"},{\"label\":\"Rho GTPase-activating protein 20\",\"id\":\"Q9P2F6\"},{\"label\":\"Rho GTPase-activating protein 21\",\"id\":\"Q5T5U3\"},{\"label\":\"Rho GTPase-activating protein 22\",\"id\":\"Q7Z5H3\"},{\"label\":\"Rho GTPase-activating protein 23\",\"id\":\"Q9P227\"},{\"label\":\"Rho GTPase-activating protein 24\",\"id\":\"Q8N264\"},{\"label\":\"Rho GTPase-activating protein 25\",\"id\":\"P42331\"},{\"label\":\"Rho GTPase-activating protein 26\",\"id\":\"Q9UNA1\"},{\"label\":\"Rho GTPase-activating protein 27\",\"id\":\"Q6ZUM4\"},{\"label\":\"Rho GTPase-activating protein 29\",\"id\":\"Q52LW3\"},{\"label\":\"Rho GTPase-activating protein 30\",\"id\":\"Q7Z6I6\"},{\"label\":\"Rho GTPase-activating protein 31\",\"id\":\"Q2M1Z3\"},{\"label\":\"Rho GTPase-activating protein 32\",\"id\":\"A7KAX9\"},{\"label\":\"Rho GTPase-activating protein 33\",\"id\":\"O14559\"},{\"label\":\"Rho GTPase-activating protein 35\",\"id\":\"Q9NRY4\"},{\"label\":\"Rho GTPase-activating protein 39\",\"id\":\"Q9C0H5\"},{\"label\":\"Rho GTPase-activating protein 42\",\"id\":\"A6NI28\"},{\"label\":\"Rho GTPase-activating protein 44\",\"id\":\"Q17R89\"},{\"label\":\"Rho GTPase-activating protein 45\",\"id\":\"Q92619\"},{\"label\":\"Rho GTPase-activating protein 4\",\"id\":\"P98171\"},{\"label\":\"Rho GTPase-activating protein 5\",\"id\":\"Q13017\"},{\"label\":\"Rho GTPase-activating protein 7\",\"id\":\"Q96QB1\"},{\"label\":\"Rho GTPase-activating protein 9\",\"id\":\"Q9BRR9\"},{\"label\":\"Rho GTPase-activating protein SYDE2\",\"id\":\"Q5VT97\"},{\"label\":\"Rho guanine nucleotide exchange factor 10\",\"id\":\"O15013\"},{\"label\":\"Rho guanine nucleotide exchange factor 11\",\"id\":\"O15085\"},{\"label\":\"Rho guanine nucleotide exchange factor 15\",\"id\":\"O94989\"},{\"label\":\"Rho guanine nucleotide exchange factor 18\",\"id\":\"Q6ZSZ5\"},{\"label\":\"Rho guanine nucleotide exchange factor 19\",\"id\":\"Q8IW93\"},{\"label\":\"Rho guanine nucleotide exchange factor 25\",\"id\":\"Q86VW2\"},{\"label\":\"Rho guanine nucleotide exchange factor 39\",\"id\":\"Q8N4T4\"},{\"label\":\"Rho guanine nucleotide exchange factor 4\",\"id\":\"Q9NR80\"},{\"label\":\"Rho guanine nucleotide exchange factor 5\",\"id\":\"Q12774\"},{\"label\":\"Rho guanine nucleotide exchange factor 6\",\"id\":\"Q15052\"},{\"label\":\"Rho guanine nucleotide exchange factor 7\",\"id\":\"Q14155\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM1\",\"id\":\"Q13009\"},{\"label\":\"Rho guanine nucleotide exchange factor TIAM2\",\"id\":\"Q8IVF5\"},{\"label\":\"SH3 domain-binding protein 1\",\"id\":\"Q9Y3L3\"},{\"label\":\"SLIT-ROBO Rho GTPase-activating protein 1\",\"id\":\"Q7Z6B7\"},{\"label\":\"SLIT-ROBO Rho GTPase-activating protein 2\",\"id\":\"O75044\"},{\"label\":\"SLIT-ROBO Rho GTPase-activating protein 3\",\"id\":\"O43295\"},{\"label\":\"Serine/threonine-protein kinase MRCK alpha\",\"id\":\"Q5VT25\"},{\"label\":\"Serine/threonine-protein kinase N1\",\"id\":\"Q16512\"},{\"label\":\"Serine/threonine-protein kinase N2\",\"id\":\"Q16513\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"},{\"label\":\"Serine/threonine-protein kinase PAK 2\",\"id\":\"Q13177\"},{\"label\":\"Serine/threonine-protein kinase PAK 3\",\"id\":\"O75914\"},{\"label\":\"Serine/threonine-protein kinase PAK 4\",\"id\":\"O96013\"},{\"label\":\"Serine/threonine-protein kinase PAK 5\",\"id\":\"Q9P286\"},{\"label\":\"Serine/threonine-protein kinase PAK 6\",\"id\":\"Q9NQU5\"},{\"label\":\"Serine/threonine-protein kinase TAO3\",\"id\":\"Q9H2K8\"},{\"label\":\"Serine/threonine-protein kinase VRK2\",\"id\":\"Q86Y07\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Son of sevenless homolog 2\",\"id\":\"Q07890\"},{\"label\":\"Spermatogenesis-associated protein 13\",\"id\":\"Q96N96\"},{\"label\":\"Switch-associated protein 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protein\",\"id\":\"Q5T442\"}]", "uniprot_id": "[\"O75712\",\"O95377\",\"O95452\",\"P08034\",\"P17302\",\"P29033\",\"P35212\",\"P36382\",\"P36383\",\"P48165\",\"P57773\",\"Q5T442\",\"Q6PEY0\",\"Q8N144\",\"Q969M2\",\"Q96KN9\",\"Q9NTQ9\",\"Q9UKL4\",\"Q9Y6H8\"]", "gene_symbol": "[\"CX25\",\"CX31\",\"CX32\",\"CX40.1\",\"CX62\",\"GJA1\",\"GJA10\",\"GJA11\",\"GJA12\",\"GJA3\",\"GJA4\",\"GJA5\",\"GJA7\",\"GJA8\",\"GJA9\",\"GJAL\",\"GJB1\",\"GJB2\",\"GJB3\",\"GJB4\",\"GJB5\",\"GJB6\",\"GJB7\",\"GJC1\",\"GJC2\",\"GJD2\",\"GJD3\",\"GJD4\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective GGT1 in aflatoxin detoxification causes GLUTH", "protein_name": "[{\"label\":\"Glutathione hydrolase 1 proenzyme\",\"id\":\"P19440\"}]", "uniprot_id": "[\"P19440\"]", "gene_symbol": "[\"GGT\",\"GGT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PI-3K cascade:FGFR1", "protein_name": "[{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Fibroblast growth factor 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"[\"O15520\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11487\",\"P27986\",\"P31371\",\"P42336\",\"Q06124\",\"Q13480\",\"Q8WU20\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF10\",\"FGF2\",\"FGF20\",\"FGF22\",\"FGF23\",\"FGF3\",\"FGF4\",\"FGF6\",\"FGF9\",\"FGFA\",\"FGFB\",\"FRS2\",\"GAB1\",\"GRB1\",\"HST\",\"HST2\",\"HSTF1\",\"HSTF2\",\"HYPF\",\"INT2\",\"KS3\",\"PIK3CA\",\"PIK3R1\",\"PTP2C\",\"PTPN11\",\"SHPTP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of gene expression in early pancreatic precursor cells", "protein_name": "[{\"label\":\"Fibroblast growth factor 10\",\"id\":\"O15520\"},{\"label\":\"Hepatocyte nuclear factor 1-beta\",\"id\":\"P35680\"},{\"label\":\"Hepatocyte nuclear factor 6\",\"id\":\"Q9UBC0\"},{\"label\":\"Homeobox protein Nkx-6.1\",\"id\":\"P78426\"},{\"label\":\"One cut domain family member 3\",\"id\":\"O60422\"},{\"label\":\"Pancreas transcription factor 1 subunit alpha\",\"id\":\"Q7RTS3\"},{\"label\":\"Pancreas/duodenum homeobox protein 1\",\"id\":\"P52945\"}]", "uniprot_id": "[\"O15520\",\"O60422\",\"P35680\",\"P52945\",\"P78426\",\"Q7RTS3\",\"Q9UBC0\"]", "gene_symbol": "[\"BHLHA29\",\"FGF10\",\"HNF1B\",\"HNF6\",\"HNF6A\",\"IPF1\",\"NKX6-1\",\"NKX6A\",\"ONECUT1\",\"ONECUT3\",\"PDX1\",\"PTF1A\",\"PTF1P48\",\"STF1\",\"TCF2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nef Mediated CD4 Down-regulation", "protein_name": "[{\"label\":\"ADP-ribosylation factor 1\",\"id\":\"P84077\"},{\"label\":\"AP-2 complex subunit alpha-1\",\"id\":\"O95782\"},{\"label\":\"AP-2 complex subunit alpha-2\",\"id\":\"O94973\"},{\"label\":\"AP-2 complex subunit beta\",\"id\":\"P63010\"},{\"label\":\"AP-2 complex subunit mu\",\"id\":\"Q96CW1\"},{\"label\":\"AP-2 complex subunit sigma\",\"id\":\"P53680\"},{\"label\":\"Protein Nef\",\"id\":\"P04601\"},{\"label\":\"T-cell surface glycoprotein CD4\",\"id\":\"P01730\"},{\"label\":\"Tyrosine-protein kinase Lck\",\"id\":\"P06239\"},{\"label\":\"V-type proton ATPase subunit H\",\"id\":\"Q9UI12\"}]", "uniprot_id": "[\"O94973\",\"O95782\",\"P01730\",\"P04601\",\"P06239\",\"P53680\",\"P63010\",\"P84077\",\"Q96CW1\",\"Q9UI12\"]", "gene_symbol": "[\"ADTAA\",\"ADTAB\",\"ADTB2\",\"AP17\",\"AP2A1\",\"AP2A2\",\"AP2B1\",\"AP2M1\",\"AP2S1\",\"ARF1\",\"ATP6V1H\",\"CD4\",\"CLAPA1\",\"CLAPA2\",\"CLAPB1\",\"CLAPM1\",\"CLAPS2\",\"HIP9\",\"HYPJ\",\"KIAA0109\",\"KIAA0899\",\"LCK\",\"nef\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation", "protein_name": "[{\"label\":\"28S rRNA (cytosine(4447)-C(5))-methyltransferase\",\"id\":\"P46087\"},{\"label\":\"60 kDa heat shock protein, mitochondrial\",\"id\":\"P10809\"},{\"label\":\"Myb-related protein B\",\"id\":\"P10244\"},{\"label\":\"Nucleophosmin\",\"id\":\"P06748\"},{\"label\":\"Transcription factor AP-2-alpha\",\"id\":\"P05549\"}]", "uniprot_id": "[\"P05549\",\"P06748\",\"P10244\",\"P10809\",\"P46087\"]", "gene_symbol": 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gamma-4\",\"id\":\"P50150\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5\",\"id\":\"P63218\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7\",\"id\":\"O60262\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8\",\"id\":\"Q9UK08\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2\",\"id\":\"O14610\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2\",\"id\":\"P62879\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(T) subunit gamma-T1\",\"id\":\"P63211\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-4\",\"id\":\"Q9HAV0\"},{\"label\":\"Guanine nucleotide-binding protein subunit beta-5\",\"id\":\"O14775\"},{\"label\":\"Rho guanine nucleotide exchange factor 6\",\"id\":\"Q15052\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"}]", "uniprot_id": "[\"O14610\",\"O14775\",\"O60262\",\"P16520\",\"P50150\",\"P50151\",\"P59768\",\"P60953\",\"P61952\",\"P62873\",\"P62879\",\"P63211\",\"P63215\",\"P63218\",\"Q13153\",\"Q15052\",\"Q9HAV0\",\"Q9P2W3\",\"Q9UBI6\",\"Q9UK08\"]", "gene_symbol": "[\"ARHGEF6\",\"CDC42\",\"COOL2\",\"GNB1\",\"GNB2\",\"GNB3\",\"GNB4\",\"GNB5\",\"GNG10\",\"GNG11\",\"GNG12\",\"GNG13\",\"GNG2\",\"GNG3\",\"GNG4\",\"GNG5\",\"GNG7\",\"GNG8\",\"GNG9\",\"GNGT1\",\"GNGT10\",\"GNGT11\",\"GNGT2\",\"GNGT3\",\"GNGT4\",\"GNGT5\",\"GNGT7\",\"GNGT8\",\"GNGT9\",\"KIAA0006\",\"PAK1\",\"PIXA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Regulation of necroptotic cell death", "protein_name": "[{\"label\":\"Baculoviral IAP repeat-containing protein 2\",\"id\":\"Q13490\"},{\"label\":\"Baculoviral IAP repeat-containing protein 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protein uL24-like\",\"id\":\"Q9UNX3\"},{\"label\":\"Ribosomal protein uL3-like\",\"id\":\"Q92901\"},{\"label\":\"Small ribosomal subunit protein eS10\",\"id\":\"P46783\"},{\"label\":\"Small ribosomal subunit protein eS12\",\"id\":\"P25398\"},{\"label\":\"Small ribosomal subunit protein eS17\",\"id\":\"P08708\"},{\"label\":\"Small ribosomal subunit protein eS19\",\"id\":\"P39019\"},{\"label\":\"Small ribosomal subunit protein eS1\",\"id\":\"P61247\"},{\"label\":\"Small ribosomal subunit protein eS21\",\"id\":\"P63220\"},{\"label\":\"Small ribosomal subunit protein eS24\",\"id\":\"P62847\"},{\"label\":\"Small ribosomal subunit protein eS25\",\"id\":\"P62851\"},{\"label\":\"Small ribosomal subunit protein eS26\",\"id\":\"P62854\"},{\"label\":\"Small ribosomal subunit protein eS27\",\"id\":\"P42677\"},{\"label\":\"Small ribosomal subunit protein eS28\",\"id\":\"P62857\"},{\"label\":\"Small ribosomal subunit protein eS32\",\"id\":\"P62945\"},{\"label\":\"Small ribosomal subunit protein eS4, 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ribosomal subunit protein uS2\",\"id\":\"P08865\"},{\"label\":\"Small ribosomal subunit protein uS3\",\"id\":\"P23396\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small ribosomal subunit protein uS7\",\"id\":\"P46782\"},{\"label\":\"Small ribosomal subunit protein uS8\",\"id\":\"P62244\"},{\"label\":\"Small ribosomal subunit protein uS9\",\"id\":\"P62249\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": 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disintegrin and metalloproteinase with thrombospondin motifs 14\",\"id\":\"Q8WXS8\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 15\",\"id\":\"Q8TE58\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 16\",\"id\":\"Q8TE57\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 17\",\"id\":\"Q8TE56\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 18\",\"id\":\"Q8TE60\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 19\",\"id\":\"Q8TE59\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 1\",\"id\":\"Q9UHI8\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 20\",\"id\":\"P59510\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 2\",\"id\":\"O95450\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 3\",\"id\":\"O15072\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 4\",\"id\":\"O75173\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 5\",\"id\":\"Q9UNA0\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 6\",\"id\":\"Q9UKP5\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 7\",\"id\":\"Q9UKP4\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 8\",\"id\":\"Q9UP79\"},{\"label\":\"A disintegrin and metalloproteinase with thrombospondin motifs 9\",\"id\":\"Q9P2N4\"},{\"label\":\"ADAMTS-like protein 1\",\"id\":\"Q8N6G6\"},{\"label\":\"ADAMTS-like protein 2\",\"id\":\"Q86TH1\"},{\"label\":\"ADAMTS-like protein 3\",\"id\":\"P82987\"},{\"label\":\"ADAMTS-like protein 4\",\"id\":\"Q6UY14\"},{\"label\":\"ADAMTS-like protein 5\",\"id\":\"Q6ZMM2\"},{\"label\":\"Beta-1,3-glucosyltransferase\",\"id\":\"Q6Y288\"},{\"label\":\"GDP-fucose protein O-fucosyltransferase 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"protein_name": "[{\"label\":\"Isocitrate dehydrogenase [NADP] cytoplasmic\",\"id\":\"O75874\"},{\"label\":\"NADP-dependent malic enzyme\",\"id\":\"P48163\"},{\"label\":\"Nuclear factor erythroid 2-related factor 2\",\"id\":\"Q16236\"}]", "uniprot_id": "[\"O75874\",\"P48163\",\"Q16236\"]", "gene_symbol": "[\"IDH1\",\"ME1\",\"NFE2L2\",\"NRF2\",\"PICD\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Erythropoietin activates RAS", "protein_name": "[{\"label\":\"Crk-like protein\",\"id\":\"P46109\"},{\"label\":\"Erythropoietin receptor\",\"id\":\"P19235\"},{\"label\":\"Erythropoietin\",\"id\":\"P01588\"},{\"label\":\"GTPase HRas\",\"id\":\"P01112\"},{\"label\":\"GTPase NRas\",\"id\":\"P01111\"},{\"label\":\"Insulin receptor substrate 2\",\"id\":\"Q9Y4H2\"},{\"label\":\"Proto-oncogene vav\",\"id\":\"P15498\"},{\"label\":\"Rap guanine nucleotide exchange factor 1\",\"id\":\"Q13905\"},{\"label\":\"SHC-transforming protein 1\",\"id\":\"P29353\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"},{\"label\":\"Tyrosine-protein kinase JAK2\",\"id\":\"O60674\"},{\"label\":\"Tyrosine-protein kinase Lyn\",\"id\":\"P07948\"}]", "uniprot_id": "[\"O60674\",\"P01111\",\"P01112\",\"P01588\",\"P07948\",\"P15498\",\"P19235\",\"P29353\",\"P46109\",\"Q07889\",\"Q13905\",\"Q9Y4H2\"]", "gene_symbol": "[\"CRKL\",\"EPO\",\"EPOR\",\"GRF2\",\"HRAS\",\"HRAS1\",\"IRS2\",\"JAK2\",\"JTK8\",\"LYN\",\"NRAS\",\"RAPGEF1\",\"SHC\",\"SHC1\",\"SHCA\",\"SOS1\",\"VAV\",\"VAV1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX3 regulates NOTCH signaling", "protein_name": "[{\"label\":\"CREB-binding protein\",\"id\":\"Q92793\"},{\"label\":\"Histone acetyltransferase KAT2A\",\"id\":\"Q92830\"},{\"label\":\"Histone acetyltransferase KAT2B\",\"id\":\"Q92831\"},{\"label\":\"Histone acetyltransferase p300\",\"id\":\"Q09472\"},{\"label\":\"Mastermind-like domain-containing protein 1\",\"id\":\"Q13495\"},{\"label\":\"Mastermind-like protein 1\",\"id\":\"Q92585\"},{\"label\":\"Mastermind-like protein 2\",\"id\":\"Q8IZL2\"},{\"label\":\"Mastermind-like protein 3\",\"id\":\"Q96JK9\"},{\"label\":\"Neurogenic locus notch homolog protein 1\",\"id\":\"P46531\"},{\"label\":\"Protein jagged-1\",\"id\":\"P78504\"},{\"label\":\"Recombining binding protein suppressor of hairless\",\"id\":\"Q06330\"},{\"label\":\"Runt-related transcription factor 3\",\"id\":\"Q13761\"},{\"label\":\"SNW domain-containing protein 1\",\"id\":\"Q13573\"},{\"label\":\"Transcription factor HES-1\",\"id\":\"Q14469\"}]", "uniprot_id": "[\"P46531\",\"P78504\",\"Q06330\",\"Q09472\",\"Q13495\",\"Q13573\",\"Q13761\",\"Q14469\",\"Q8IZL2\",\"Q92585\",\"Q92793\",\"Q92830\",\"Q92831\",\"Q96JK9\"]", "gene_symbol": 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P450 2B6\",\"id\":\"P20813\"},{\"label\":\"Cytochrome P450 2C18\",\"id\":\"P33260\"},{\"label\":\"Cytochrome P450 2C19\",\"id\":\"P33261\"},{\"label\":\"Cytochrome P450 2C8\",\"id\":\"P10632\"},{\"label\":\"Cytochrome P450 2C9\",\"id\":\"P11712\"},{\"label\":\"Cytochrome P450 2D6\",\"id\":\"P10635\"},{\"label\":\"Cytochrome P450 2E1\",\"id\":\"P05181\"},{\"label\":\"Cytochrome P450 2F1\",\"id\":\"P24903\"},{\"label\":\"Cytochrome P450 2J2\",\"id\":\"P51589\"},{\"label\":\"Cytochrome P450 2S1\",\"id\":\"Q96SQ9\"},{\"label\":\"Cytochrome P450 2W1\",\"id\":\"Q8TAV3\"},{\"label\":\"Cytochrome P450 3A43\",\"id\":\"Q9HB55\"},{\"label\":\"Cytochrome P450 3A4\",\"id\":\"P08684\"},{\"label\":\"Cytochrome P450 3A5\",\"id\":\"P20815\"},{\"label\":\"Cytochrome P450 3A7\",\"id\":\"P24462\"}]", "uniprot_id": "[\"A9YTQ3\",\"P04798\",\"P05181\",\"P08684\",\"P10632\",\"P10635\",\"P11509\",\"P11712\",\"P20813\",\"P20815\",\"P20853\",\"P24462\",\"P24903\",\"P27540\",\"P33260\",\"P33261\",\"P35869\",\"P51589\",\"Q16696\",\"Q8TAV3\",\"Q96SQ9\",\"Q9HB55\",\"Q9HBZ2\"]", "gene_symbol": "[\"AHR\",\"AHRR\",\"ARNT\",\"ARNT2\",\"BHLHE1\",\"BHLHE2\",\"BHLHE76\",\"BHLHE77\",\"CYP1A1\",\"CYP2A13\",\"CYP2A3\",\"CYP2A6\",\"CYP2A7\",\"CYP2B6\",\"CYP2C10\",\"CYP2C18\",\"CYP2C19\",\"CYP2C8\",\"CYP2C9\",\"CYP2D6\",\"CYP2DL1\",\"CYP2E\",\"CYP2E1\",\"CYP2F1\",\"CYP2J2\",\"CYP2S1\",\"CYP2W1\",\"CYP3A3\",\"CYP3A4\",\"CYP3A43\",\"CYP3A5\",\"CYP3A7\",\"KIAA0307\",\"KIAA1234\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "ALPK1 signaling pathway", "protein_name": "[{\"label\":\"Alpha-protein kinase 1\",\"id\":\"Q96QP1\"},{\"label\":\"Mitogen-activated protein kinase kinase kinase 7\",\"id\":\"O43318\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 1\",\"id\":\"Q15750\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2\",\"id\":\"Q9NYJ8\"},{\"label\":\"TGF-beta-activated kinase 1 and MAP3K7-binding protein 3\",\"id\":\"Q8N5C8\"},{\"label\":\"TNF receptor-associated factor 6\",\"id\":\"Q9Y4K3\"},{\"label\":\"TRAF-interacting protein with FHA domain-containing protein A\",\"id\":\"Q96CG3\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O43318\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q15750\",\"Q8N5C8\",\"Q96CG3\",\"Q96QP1\",\"Q9NYJ8\",\"Q9Y4K3\"]", "gene_symbol": 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1\",\"id\":\"Q9Y4D1\"},{\"label\":\"Frizzled-1\",\"id\":\"Q9UP38\"},{\"label\":\"Frizzled-3\",\"id\":\"Q9NPG1\"},{\"label\":\"Frizzled-6\",\"id\":\"O60353\"},{\"label\":\"Frizzled-7\",\"id\":\"O75084\"},{\"label\":\"Profilin-1\",\"id\":\"P07737\"},{\"label\":\"Protein Wnt-11\",\"id\":\"O96014\"},{\"label\":\"Protein Wnt-4\",\"id\":\"P56705\"},{\"label\":\"Protein Wnt-5a\",\"id\":\"P41221\"},{\"label\":\"Protein Wnt-5b\",\"id\":\"Q9H1J7\"},{\"label\":\"Proto-oncogene Wnt-1\",\"id\":\"P04628\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 2\",\"id\":\"P15153\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 3\",\"id\":\"P60763\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-1\",\"id\":\"O14640\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-2\",\"id\":\"O14641\"},{\"label\":\"Segment polarity protein dishevelled homolog DVL-3\",\"id\":\"Q92997\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"},{\"label\":\"Tyrosine-protein kinase RYK\",\"id\":\"P34925\"},{\"label\":\"Tyrosine-protein kinase transmembrane receptor ROR2\",\"id\":\"Q01974\"},{\"label\":\"Vang-like protein 2\",\"id\":\"Q9ULK5\"}]", "uniprot_id": "[\"O14640\",\"O14641\",\"O60353\",\"O75084\",\"O96014\",\"P04628\",\"P07737\",\"P15153\",\"P34925\",\"P41221\",\"P56705\",\"P60763\",\"P61586\",\"P63000\",\"Q01974\",\"Q92997\",\"Q9H1J7\",\"Q9NPG1\",\"Q9ULK5\",\"Q9UP38\",\"Q9Y4D1\"]", "gene_symbol": "[\"ARH12\",\"ARHA\",\"DAAM1\",\"DVL1\",\"DVL2\",\"DVL3\",\"FZD1\",\"FZD3\",\"FZD6\",\"FZD7\",\"INT1\",\"JTK5A\",\"KIAA0208\",\"KIAA0666\",\"KIAA1215\",\"NTRKR2\",\"PFN1\",\"RAC1\",\"RAC2\",\"RAC3\",\"RHO12\",\"RHOA\",\"ROR2\",\"RYK\",\"STB1\",\"TC25\",\"VANGL2\",\"WNT1\",\"WNT11\",\"WNT4\",\"WNT5A\",\"WNT5B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Miscellaneous transport and binding events", "protein_name": 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protein\",\"id\":\"P12273\"},{\"label\":\"Tumor suppressor candidate 3\",\"id\":\"Q13454\"},{\"label\":\"Volume-regulated anion channel subunit LRRC8A\",\"id\":\"Q8IWT6\"},{\"label\":\"Volume-regulated anion channel subunit LRRC8B\",\"id\":\"Q6P9F7\"},{\"label\":\"Volume-regulated anion channel subunit LRRC8C\",\"id\":\"Q8TDW0\"},{\"label\":\"Volume-regulated anion channel subunit LRRC8D\",\"id\":\"Q7L1W4\"},{\"label\":\"Volume-regulated anion channel subunit LRRC8E\",\"id\":\"Q6NSJ5\"},{\"label\":\"Zinc-alpha-2-glycoprotein\",\"id\":\"P25311\"}]", "uniprot_id": "[\"O60931\",\"P12273\",\"P25311\",\"P35611\",\"P35612\",\"Q08495\",\"Q0D2K0\",\"Q13454\",\"Q6NSJ5\",\"Q6NVV3\",\"Q6P499\",\"Q6P9F7\",\"Q6ZP29\",\"Q7L1W4\",\"Q7RTP0\",\"Q8IWT6\",\"Q8N4V1\",\"Q8N8Q9\",\"Q8TDW0\",\"Q9H0U3\",\"Q9H841\",\"Q9HCJ1\",\"Q9HD23\",\"Q9UEY8\"]", "gene_symbol": 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epsilon\",\"id\":\"Q9NUQ2\"},{\"label\":\"1-acyl-sn-glycerol-3-phosphate acyltransferase gamma\",\"id\":\"Q9NRZ7\"},{\"label\":\"Cytosolic phospholipase A2 beta\",\"id\":\"P0C869\"},{\"label\":\"Cytosolic phospholipase A2 delta\",\"id\":\"Q86XP0\"},{\"label\":\"Cytosolic phospholipase A2\",\"id\":\"P47712\"},{\"label\":\"Dihydroxyacetone phosphate acyltransferase\",\"id\":\"O15228\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 1, mitochondrial\",\"id\":\"Q9HCL2\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 2, mitochondrial\",\"id\":\"Q6NUI2\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 3\",\"id\":\"Q53EU6\"},{\"label\":\"Glycerol-3-phosphate acyltransferase 4\",\"id\":\"Q86UL3\"},{\"label\":\"Glycerol-3-phosphate dehydrogenase 1-like protein\",\"id\":\"Q8N335\"},{\"label\":\"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic\",\"id\":\"P21695\"},{\"label\":\"Glycerol-3-phosphate dehydrogenase, mitochondrial\",\"id\":\"P43304\"},{\"label\":\"Group 10 secretory phospholipase A2\",\"id\":\"O15496\"},{\"label\":\"Group IID secretory phospholipase A2\",\"id\":\"Q9UNK4\"},{\"label\":\"Group IIE secretory phospholipase A2\",\"id\":\"Q9NZK7\"},{\"label\":\"Group IIF secretory phospholipase A2\",\"id\":\"Q9BZM2\"},{\"label\":\"Group XIIA secretory phospholipase A2\",\"id\":\"Q9BZM1\"},{\"label\":\"Intestinal-type alkaline phosphatase\",\"id\":\"P09923\"},{\"label\":\"Lipase member H\",\"id\":\"Q8WWY8\"},{\"label\":\"Lipase member I\",\"id\":\"Q6XZB0\"},{\"label\":\"Lysocardiolipin acyltransferase 1\",\"id\":\"Q6UWP7\"},{\"label\":\"Lysophosphatidic acid phosphatase type 6\",\"id\":\"Q9NPH0\"},{\"label\":\"Lysophosphatidylcholine acyltransferase 1\",\"id\":\"Q8NF37\"},{\"label\":\"Lysophospholipid acyltransferase LPCAT4\",\"id\":\"Q643R3\"},{\"label\":\"Mitochondrial cardiolipin hydrolase\",\"id\":\"Q8N2A8\"},{\"label\":\"Mitoguardin 1\",\"id\":\"Q8NAN2\"},{\"label\":\"Mitoguardin 2\",\"id\":\"Q7L4E1\"},{\"label\":\"Phospholipase A2 group 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7A1\",\"id\":\"P22680\"},{\"label\":\"Cytochrome P450 7B1\",\"id\":\"O75881\"},{\"label\":\"Nuclear receptor coactivator 1\",\"id\":\"Q15788\"},{\"label\":\"Nuclear receptor coactivator 2\",\"id\":\"Q15596\"},{\"label\":\"Oxysterol-binding protein 1\",\"id\":\"P22059\"},{\"label\":\"Oxysterol-binding protein-related protein 1\",\"id\":\"Q9BXW6\"},{\"label\":\"Oxysterol-binding protein-related protein 2\",\"id\":\"Q9H1P3\"},{\"label\":\"Oxysterol-binding protein-related protein 3\",\"id\":\"Q9H4L5\"},{\"label\":\"Oxysterol-binding protein-related protein 6\",\"id\":\"Q9BZF3\"},{\"label\":\"Oxysterol-binding protein-related protein 7\",\"id\":\"Q9BZF2\"},{\"label\":\"Oxysterol-binding protein-related protein 9\",\"id\":\"Q96SU4\"},{\"label\":\"Retinoic acid receptor RXR-alpha\",\"id\":\"P19793\"}]", "uniprot_id": "[\"O75881\",\"O95992\",\"P19793\",\"P22059\",\"P22680\",\"Q15596\",\"Q15788\",\"Q96RI1\",\"Q96SU4\",\"Q9BXW6\",\"Q9BZF2\",\"Q9BZF3\",\"Q9H1P3\",\"Q9H4L5\"]", "gene_symbol": 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factor receptor alpha\",\"id\":\"P16234\"}]", "uniprot_id": "[\"P16234\"]", "gene_symbol": "[\"PDGFR2\",\"PDGFRA\",\"RHEPDGFRA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Scavenging by Class H Receptors", "protein_name": "[{\"label\":\"Apolipoprotein B-100\",\"id\":\"P04114\"},{\"label\":\"SPARC\",\"id\":\"P09486\"},{\"label\":\"Stabilin-1\",\"id\":\"Q9NY15\"},{\"label\":\"Stabilin-2\",\"id\":\"Q8WWQ8\"}]", "uniprot_id": "[\"P04114\",\"P09486\",\"Q8WWQ8\",\"Q9NY15\"]", "gene_symbol": "[\"APOB\",\"FEEL1\",\"FEEL2\",\"FELL\",\"FEX2\",\"HARE\",\"KIAA0246\",\"ON\",\"SPARC\",\"STAB1\",\"STAB2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NOTCH4 Activation and Transmission of Signal to the Nucleus", "protein_name": "[{\"label\":\"14-3-3 protein zeta/delta\",\"id\":\"P63104\"},{\"label\":\"Delta-like protein 4\",\"id\":\"Q9NR61\"},{\"label\":\"Disintegrin and metalloproteinase domain-containing protein 10\",\"id\":\"O14672\"},{\"label\":\"Gamma-secretase subunit 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mitochondrial\",\"id\":\"Q5JTZ9\"},{\"label\":\"Asparaginyl-tRNA synthetase\",\"id\":\"Q96I59\"},{\"label\":\"Aspartate--tRNA ligase, mitochondrial\",\"id\":\"Q6PI48\"},{\"label\":\"Glutamine--tRNA ligase\",\"id\":\"P47897\"},{\"label\":\"Glycine--tRNA ligase\",\"id\":\"P41250\"},{\"label\":\"Histidine--tRNA ligase, mitochondrial\",\"id\":\"P49590\"},{\"label\":\"Inorganic pyrophosphatase 2, mitochondrial\",\"id\":\"Q9H2U2\"},{\"label\":\"Isoleucine--tRNA ligase, mitochondrial\",\"id\":\"Q9NSE4\"},{\"label\":\"Leucine--tRNA ligase, mitochondrial\",\"id\":\"Q15031\"},{\"label\":\"Lysine--tRNA ligase\",\"id\":\"Q15046\"},{\"label\":\"Methionine--tRNA ligase, mitochondrial\",\"id\":\"Q96GW9\"},{\"label\":\"Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial\",\"id\":\"Q5JPH6\"},{\"label\":\"Phenylalanine--tRNA ligase, mitochondrial\",\"id\":\"O95363\"},{\"label\":\"Probable arginine--tRNA ligase, mitochondrial\",\"id\":\"Q5T160\"},{\"label\":\"Probable cysteine--tRNA ligase, 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"[\"AARS2\",\"AARSL\",\"CARS2\",\"DARS2\",\"EARS2\",\"FARS1\",\"FARS2\",\"GARS\",\"GARS1\",\"HARS2\",\"HARSL\",\"HARSR\",\"HO3\",\"IARS2\",\"KARS\",\"KARS1\",\"KIAA0028\",\"KIAA0070\",\"KIAA1270\",\"KIAA1885\",\"KIAA1970\",\"LARS2\",\"MARS2\",\"NARS2\",\"PARS2\",\"PPA2\",\"QARS\",\"QARS1\",\"RARS2\",\"RARSL\",\"SARS2\",\"SARSM\",\"TARS2\",\"TARSL1\",\"VARS2\",\"VARS2L\",\"VARSL\",\"WARS2\",\"YARS2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)", "protein_name": "[{\"label\":\"Sodium- and chloride-dependent transporter XTRP3\",\"id\":\"Q9NP91\"}]", "uniprot_id": "[\"Q9NP91\"]", "gene_symbol": "[\"SIT1\",\"SLC6A20\",\"XT3\",\"XTRP3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Replication of the SARS-CoV-2 genome", "protein_name": "[{\"label\":\"Probable ATP-dependent RNA helicase DDX5\",\"id\":\"P17844\"},{\"label\":\"Replicase polyprotein 1a\",\"id\":\"P0DTC1\"},{\"label\":\"Replicase polyprotein 1ab\",\"id\":\"P0DTD1\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Zinc finger CCHC-type and RNA-binding motif-containing protein 1\",\"id\":\"Q8TBF4\"},{\"label\":\"von Hippel-Lindau disease tumor suppressor\",\"id\":\"P40337\"}]", "uniprot_id": "[\"P06400\",\"P0DTC1\",\"P0DTD1\",\"P17844\",\"P40337\",\"Q8TBF4\"]", "gene_symbol": "[\"DDX5\",\"G17P1\",\"HELR\",\"HLR1\",\"RB1\",\"VHL\",\"ZCRB1\",\"rep\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Gap junction degradation", "protein_name": "[{\"label\":\"AP-2 complex subunit mu\",\"id\":\"Q96CW1\"},{\"label\":\"Clathrin heavy chain 1\",\"id\":\"Q00610\"},{\"label\":\"Clathrin heavy chain 2\",\"id\":\"P53675\"},{\"label\":\"Clathrin light chain A\",\"id\":\"P09496\"},{\"label\":\"Clathrin light chain B\",\"id\":\"P09497\"},{\"label\":\"Disabled homolog 2\",\"id\":\"P98082\"},{\"label\":\"Dynamin-1\",\"id\":\"Q05193\"},{\"label\":\"Dynamin-2\",\"id\":\"P50570\"},{\"label\":\"Gap junction alpha-1 protein\",\"id\":\"P17302\"},{\"label\":\"Unconventional myosin-VI\",\"id\":\"Q9UM54\"}]", "uniprot_id": "[\"P09496\",\"P09497\",\"P17302\",\"P50570\",\"P53675\",\"P98082\",\"Q00610\",\"Q05193\",\"Q96CW1\",\"Q9UM54\"]", "gene_symbol": "[\"AP2M1\",\"CLAPM1\",\"CLH17\",\"CLH22\",\"CLTA\",\"CLTB\",\"CLTC\",\"CLTCL\",\"CLTCL1\",\"CLTCL2\",\"CLTD\",\"DAB2\",\"DNM\",\"DNM1\",\"DNM2\",\"DOC2\",\"DYN2\",\"GJA1\",\"GJAL\",\"KIAA0034\",\"KIAA0109\",\"KIAA0389\",\"MYO6\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Adrenoceptors", "protein_name": "[{\"label\":\"Alpha-1A adrenergic receptor\",\"id\":\"P35348\"},{\"label\":\"Alpha-1B adrenergic receptor\",\"id\":\"P35368\"},{\"label\":\"Alpha-1D adrenergic receptor\",\"id\":\"P25100\"},{\"label\":\"Alpha-2A adrenergic receptor\",\"id\":\"P08913\"},{\"label\":\"Alpha-2B adrenergic receptor\",\"id\":\"P18089\"},{\"label\":\"Alpha-2C adrenergic receptor\",\"id\":\"P18825\"},{\"label\":\"Beta-1 adrenergic receptor\",\"id\":\"P08588\"},{\"label\":\"Beta-2 adrenergic receptor\",\"id\":\"P07550\"},{\"label\":\"Beta-3 adrenergic receptor\",\"id\":\"P13945\"}]", "uniprot_id": "[\"P07550\",\"P08588\",\"P08913\",\"P13945\",\"P18089\",\"P18825\",\"P25100\",\"P35348\",\"P35368\"]", "gene_symbol": "[\"ADRA1A\",\"ADRA1B\",\"ADRA1C\",\"ADRA1D\",\"ADRA2A\",\"ADRA2B\",\"ADRA2C\",\"ADRA2L1\",\"ADRA2L2\",\"ADRA2R\",\"ADRA2RL1\",\"ADRA2RL2\",\"ADRAR\",\"ADRB1\",\"ADRB1R\",\"ADRB2\",\"ADRB2R\",\"ADRB3\",\"ADRB3R\",\"B1AR\",\"B2AR\",\"B3AR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-18 signaling", "protein_name": "[{\"label\":\"Interleukin-13\",\"id\":\"P35225\"},{\"label\":\"Interleukin-18 receptor 1\",\"id\":\"Q13478\"},{\"label\":\"Interleukin-18 receptor accessory protein\",\"id\":\"O95256\"},{\"label\":\"Interleukin-18-binding protein\",\"id\":\"O95998\"},{\"label\":\"Interleukin-18\",\"id\":\"Q14116\"},{\"label\":\"Interleukin-37\",\"id\":\"Q9NZH6\"},{\"label\":\"Interleukin-4\",\"id\":\"P05112\"},{\"label\":\"Polyunsaturated fatty acid 5-lipoxygenase\",\"id\":\"P09917\"}]", "uniprot_id": "[\"O95256\",\"O95998\",\"P05112\",\"P09917\",\"P35225\",\"Q13478\",\"Q14116\",\"Q9NZH6\"]", "gene_symbol": "[\"ALOX5\",\"FIL1Z\",\"IGIF\",\"IL13\",\"IL18\",\"IL18BP\",\"IL18R1\",\"IL18RAP\",\"IL1F4\",\"IL1F7\",\"IL1H4\",\"IL1R7\",\"IL1RP1\",\"IL1RRP\",\"IL37\",\"IL4\",\"LOG5\",\"NC30\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)", "protein_name": "[{\"label\":\"Chloride anion exchanger\",\"id\":\"P40879\"}]", "uniprot_id": "[\"P40879\"]", "gene_symbol": "[\"DRA\",\"SLC26A3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "GSD IV", "protein_name": "[{\"label\":\"1,4-alpha-glucan-branching enzyme\",\"id\":\"Q04446\"},{\"label\":\"Glycogen [starch] synthase, liver\",\"id\":\"P54840\"},{\"label\":\"Glycogenin-2\",\"id\":\"O15488\"}]", "uniprot_id": "[\"O15488\",\"P54840\",\"Q04446\"]", "gene_symbol": "[\"GBE1\",\"GYG2\",\"GYS2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Metabolism of serotonin", "protein_name": "[{\"label\":\"Aldehyde dehydrogenase, mitochondrial\",\"id\":\"P05091\"},{\"label\":\"Amine oxidase [flavin-containing] A\",\"id\":\"P21397\"}]", "uniprot_id": "[\"P05091\",\"P21397\"]", "gene_symbol": "[\"ALDH2\",\"ALDM\",\"MAOA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Acyl chain remodeling of CL", "protein_name": "[{\"label\":\"85/88 kDa calcium-independent phospholipase A2\",\"id\":\"O60733\"},{\"label\":\"Cytosolic phospholipase A2\",\"id\":\"P47712\"},{\"label\":\"Lysocardiolipin acyltransferase 1\",\"id\":\"Q6UWP7\"},{\"label\":\"Tafazzin\",\"id\":\"Q16635\"},{\"label\":\"Trifunctional enzyme subunit alpha, mitochondrial\",\"id\":\"P40939\"},{\"label\":\"Trifunctional enzyme subunit beta, mitochondrial\",\"id\":\"P55084\"}]", "uniprot_id": "[\"O60733\",\"P40939\",\"P47712\",\"P55084\",\"Q16635\",\"Q6UWP7\"]", "gene_symbol": "[\"AGPAT8\",\"ALCAT1\",\"CPLA2\",\"EFE2\",\"G4.5\",\"HADH\",\"HADHA\",\"HADHB\",\"LCLAT1\",\"LYCAT\",\"PLA2G4\",\"PLA2G4A\",\"PLA2G6\",\"PLPLA9\",\"TAFAZZIN\",\"TAZ\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "MyD88 deficiency (TLR2/4)", "protein_name": "[{\"label\":\"Fibrinogen alpha chain\",\"id\":\"P02671\"},{\"label\":\"Fibrinogen beta chain\",\"id\":\"P02675\"},{\"label\":\"Fibrinogen gamma chain\",\"id\":\"P02679\"},{\"label\":\"High mobility group protein B1\",\"id\":\"P09429\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Major outer membrane protein P.IB\",\"id\":\"P30690\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Myeloid differentiation primary response protein MyD88\",\"id\":\"Q99836\"},{\"label\":\"Peptidyl-prolyl cis-trans isomerase Mip\",\"id\":\"P26623\"},{\"label\":\"Platelet glycoprotein 4\",\"id\":\"P16671\"},{\"label\":\"Protein S100-A1\",\"id\":\"P23297\"},{\"label\":\"Protein S100-A8\",\"id\":\"P05109\"},{\"label\":\"Protein S100-A9\",\"id\":\"P06702\"},{\"label\":\"Toll-like receptor 1\",\"id\":\"Q15399\"},{\"label\":\"Toll-like receptor 2\",\"id\":\"O60603\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Toll-like receptor 6\",\"id\":\"Q9Y2C9\"},{\"label\":\"Toll/interleukin-1 receptor domain-containing adapter protein\",\"id\":\"P58753\"},{\"label\":\"Tyrosine-protein kinase BTK\",\"id\":\"Q06187\"}]", "uniprot_id": "[\"O00206\",\"O60603\",\"P02671\",\"P02675\",\"P02679\",\"P05109\",\"P06702\",\"P08571\",\"P09429\",\"P16671\",\"P23297\",\"P26623\",\"P30690\",\"P58753\",\"Q06187\",\"Q15399\",\"Q99836\",\"Q9Y2C9\",\"Q9Y6Y9\"]", "gene_symbol": 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protein\",\"id\":\"P35638\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 1\",\"id\":\"P05198\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 2\",\"id\":\"P20042\"},{\"label\":\"Eukaryotic translation initiation factor 2 subunit 3\",\"id\":\"P41091\"},{\"label\":\"Large ribosomal subunit protein P1\",\"id\":\"P05386\"},{\"label\":\"Large ribosomal subunit protein P2\",\"id\":\"P05387\"},{\"label\":\"Large ribosomal subunit protein eL13\",\"id\":\"P26373\"},{\"label\":\"Large ribosomal subunit protein eL14\",\"id\":\"P50914\"},{\"label\":\"Large ribosomal subunit protein eL15\",\"id\":\"P61313\"},{\"label\":\"Large ribosomal subunit protein eL18\",\"id\":\"Q07020\"},{\"label\":\"Large ribosomal subunit protein eL19\",\"id\":\"P84098\"},{\"label\":\"Large ribosomal subunit protein eL20\",\"id\":\"Q02543\"},{\"label\":\"Large ribosomal subunit protein eL21\",\"id\":\"P46778\"},{\"label\":\"Large ribosomal subunit protein eL22\",\"id\":\"P35268\"},{\"label\":\"Large ribosomal subunit protein eL24\",\"id\":\"P83731\"},{\"label\":\"Large ribosomal subunit protein eL27\",\"id\":\"P61353\"},{\"label\":\"Large ribosomal subunit protein eL28\",\"id\":\"P46779\"},{\"label\":\"Large ribosomal subunit protein eL29\",\"id\":\"P47914\"},{\"label\":\"Large ribosomal subunit protein eL30\",\"id\":\"P62888\"},{\"label\":\"Large ribosomal subunit protein eL31\",\"id\":\"P62899\"},{\"label\":\"Large ribosomal subunit protein eL32\",\"id\":\"P62910\"},{\"label\":\"Large ribosomal subunit protein eL33\",\"id\":\"P18077\"},{\"label\":\"Large ribosomal subunit protein eL34\",\"id\":\"P49207\"},{\"label\":\"Large ribosomal subunit protein eL36\",\"id\":\"Q9Y3U8\"},{\"label\":\"Large ribosomal subunit protein eL37\",\"id\":\"P61927\"},{\"label\":\"Large ribosomal subunit protein eL38\",\"id\":\"P63173\"},{\"label\":\"Large ribosomal subunit protein eL39\",\"id\":\"P62891\"},{\"label\":\"Large ribosomal subunit protein eL42\",\"id\":\"P83881\"},{\"label\":\"Large ribosomal subunit protein eL43\",\"id\":\"P61513\"},{\"label\":\"Large ribosomal subunit protein eL6\",\"id\":\"Q02878\"},{\"label\":\"Large ribosomal subunit protein eL8\",\"id\":\"P62424\"},{\"label\":\"Large ribosomal subunit protein uL10\",\"id\":\"P05388\"},{\"label\":\"Large ribosomal subunit protein uL11\",\"id\":\"P30050\"},{\"label\":\"Large ribosomal subunit protein uL13\",\"id\":\"P40429\"},{\"label\":\"Large ribosomal subunit protein uL14\",\"id\":\"P62829\"},{\"label\":\"Large ribosomal subunit protein uL15\",\"id\":\"P46776\"},{\"label\":\"Large ribosomal subunit protein uL16\",\"id\":\"P27635\"},{\"label\":\"Large ribosomal subunit protein uL18\",\"id\":\"P46777\"},{\"label\":\"Large ribosomal subunit protein uL1\",\"id\":\"P62906\"},{\"label\":\"Large ribosomal subunit protein uL22\",\"id\":\"P18621\"},{\"label\":\"Large ribosomal subunit protein uL23\",\"id\":\"P62750\"},{\"label\":\"Large ribosomal subunit protein 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ribosomal subunit protein uS3\",\"id\":\"P23396\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small ribosomal subunit protein uS7\",\"id\":\"P46782\"},{\"label\":\"Small ribosomal subunit protein uS8\",\"id\":\"P62244\"},{\"label\":\"Small ribosomal subunit protein uS9\",\"id\":\"P62249\"},{\"label\":\"Stalled ribosome sensor GCN1\",\"id\":\"Q92616\"},{\"label\":\"Tribbles homolog 3\",\"id\":\"Q96RU7\"},{\"label\":\"Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein\",\"id\":\"P62861\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"},{\"label\":\"eIF-2-alpha kinase GCN2\",\"id\":\"Q9P2K8\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "HSF1-dependent transactivation", "protein_name": "[{\"label\":\"Alpha-crystallin B chain\",\"id\":\"P02511\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit alpha\",\"id\":\"Q9UQM7\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit beta\",\"id\":\"Q13554\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit delta\",\"id\":\"Q13557\"},{\"label\":\"Calcium/calmodulin-dependent protein kinase type II subunit gamma\",\"id\":\"Q13555\"},{\"label\":\"DnaJ homolog subfamily B member 1\",\"id\":\"P25685\"},{\"label\":\"Heat shock 70 kDa protein 1-like\",\"id\":\"P34931\"},{\"label\":\"Heat shock 70 kDa protein 1A\",\"id\":\"P0DMV8\"},{\"label\":\"Heat shock 70 kDa protein 1B\",\"id\":\"P0DMV9\"},{\"label\":\"Heat shock cognate 71 kDa protein\",\"id\":\"P11142\"},{\"label\":\"Heat shock factor protein 1\",\"id\":\"Q00613\"},{\"label\":\"Heat shock factor-binding protein 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PP1-alpha catalytic subunit\",\"id\":\"P62136\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit alpha\",\"id\":\"P17612\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit beta\",\"id\":\"P22694\"},{\"label\":\"cAMP-dependent protein kinase catalytic subunit gamma\",\"id\":\"P22612\"},{\"label\":\"cAMP-dependent protein kinase type I-alpha regulatory subunit\",\"id\":\"P10644\"},{\"label\":\"cAMP-dependent protein kinase type I-beta regulatory subunit\",\"id\":\"P31321\"},{\"label\":\"cAMP-dependent protein kinase type II-alpha regulatory subunit\",\"id\":\"P13861\"},{\"label\":\"cAMP-dependent protein kinase type II-beta regulatory subunit\",\"id\":\"P31323\"}]", "uniprot_id": "[\"P0DP23\",\"P10644\",\"P13861\",\"P16298\",\"P17612\",\"P22612\",\"P22694\",\"P27815\",\"P30153\",\"P30154\",\"P31321\",\"P31323\",\"P48454\",\"P62136\",\"P62714\",\"P63098\",\"P67775\",\"Q00535\",\"Q08209\",\"Q08493\",\"Q08499\",\"Q14738\",\"Q9UD71\"]", "gene_symbol": 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repeat and PH domain-containing protein 2\",\"id\":\"Q99490\"},{\"label\":\"E3 ubiquitin-protein ligase SIAH1\",\"id\":\"Q8IUQ4\"},{\"label\":\"E3 ubiquitin-protein ligase SIAH2\",\"id\":\"O43255\"},{\"label\":\"Ezrin\",\"id\":\"P15311\"},{\"label\":\"Hemojuvelin\",\"id\":\"Q6ZVN8\"},{\"label\":\"Neogenin\",\"id\":\"Q92859\"},{\"label\":\"Netrin receptor DCC\",\"id\":\"P43146\"},{\"label\":\"Netrin receptor UNC5A\",\"id\":\"Q6ZN44\"},{\"label\":\"Netrin receptor UNC5B\",\"id\":\"Q8IZJ1\"},{\"label\":\"Netrin-1\",\"id\":\"O95631\"},{\"label\":\"Netrin-4\",\"id\":\"Q9HB63\"},{\"label\":\"Protein kinase C theta type\",\"id\":\"Q04759\"},{\"label\":\"Repulsive guidance molecule A\",\"id\":\"Q96B86\"},{\"label\":\"Repulsive guidance molecule B\",\"id\":\"Q6NW40\"},{\"label\":\"Roundabout homolog 1\",\"id\":\"Q9Y6N7\"},{\"label\":\"Slit homolog 1 protein\",\"id\":\"O75093\"},{\"label\":\"Slit homolog 2 protein\",\"id\":\"O94813\"},{\"label\":\"Slit homolog 3 protein\",\"id\":\"O75094\"},{\"label\":\"Unconventional myosin-X\",\"id\":\"Q9HD67\"}]", "uniprot_id": "[\"O43255\",\"O75093\",\"O75094\",\"O94813\",\"O95631\",\"P15311\",\"P43146\",\"Q04759\",\"Q6NW40\",\"Q6ZN44\",\"Q6ZVN8\",\"Q8IUQ4\",\"Q8IZJ1\",\"Q92859\",\"Q96B86\",\"Q99490\",\"Q9HB63\",\"Q9HD67\",\"Q9Y6N7\"]", "gene_symbol": "[\"AGAP2\",\"CENTG1\",\"DCC\",\"DUTT1\",\"EZR\",\"HFE2\",\"HJV\",\"HUMSIAH\",\"IGDCC1\",\"IGDCC2\",\"KIAA0167\",\"KIAA0799\",\"KIAA0813\",\"KIAA0814\",\"KIAA1976\",\"MEGF4\",\"MEGF5\",\"MYO10\",\"NEO1\",\"NGN\",\"NTN1\",\"NTN1L\",\"NTN4\",\"P53RDL1\",\"PRKCQ\",\"PRKCT\",\"RGM\",\"RGMA\",\"RGMB\",\"RGMC\",\"ROBO1\",\"SIAH1\",\"SIAH2\",\"SLIL1\",\"SLIL2\",\"SLIL3\",\"SLIT1\",\"SLIT2\",\"SLIT3\",\"UNC5A\",\"UNC5B\",\"UNC5H1\",\"UNC5H2\",\"VIL2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "CTLA4 inhibitory signaling", "protein_name": "[{\"label\":\"Cytotoxic T-lymphocyte protein 4\",\"id\":\"P16410\"},{\"label\":\"RAC-alpha serine/threonine-protein 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"[\"\"]" }, { "pathway_label": "RUNX2 regulates genes involved in differentiation of myeloid cells", "protein_name": "[{\"label\":\"Core-binding factor subunit beta\",\"id\":\"Q13951\"},{\"label\":\"Galectin-3\",\"id\":\"P17931\"},{\"label\":\"Runt-related transcription factor 1\",\"id\":\"Q01196\"}]", "uniprot_id": "[\"P17931\",\"Q01196\",\"Q13951\"]", "gene_symbol": "[\"AML1\",\"CBFA2\",\"CBFB\",\"LGALS3\",\"MAC2\",\"RUNX1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective ABCA3 causes SMDP3", "protein_name": "[{\"label\":\"Phospholipid-transporting ATPase ABCA3\",\"id\":\"Q99758\"}]", "uniprot_id": "[\"Q99758\"]", "gene_symbol": "[\"ABC3\",\"ABCA3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signalling to STAT3", "protein_name": "[{\"label\":\"Beta-nerve growth factor\",\"id\":\"P01138\"},{\"label\":\"High affinity nerve growth factor receptor\",\"id\":\"P04629\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"}]", "uniprot_id": 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13\",\"id\":\"Q9UNM6\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 14\",\"id\":\"O00487\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 1\",\"id\":\"Q99460\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 2\",\"id\":\"Q13200\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 3\",\"id\":\"O43242\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 6\",\"id\":\"Q15008\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 7\",\"id\":\"P51665\"},{\"label\":\"26S proteasome non-ATPase regulatory subunit 8\",\"id\":\"P48556\"},{\"label\":\"26S proteasome regulatory subunit 10B\",\"id\":\"P62333\"},{\"label\":\"26S proteasome regulatory subunit 4\",\"id\":\"P62191\"},{\"label\":\"26S proteasome regulatory subunit 6A\",\"id\":\"P17980\"},{\"label\":\"26S proteasome regulatory subunit 6B\",\"id\":\"P43686\"},{\"label\":\"26S proteasome regulatory subunit 7\",\"id\":\"P35998\"},{\"label\":\"26S proteasome regulatory subunit 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"gtc_id": "[\"\"]" }, { "pathway_label": "Downregulation of ERBB2 signaling", "protein_name": "[{\"label\":\"Cullin-5\",\"id\":\"Q93034\"},{\"label\":\"E3 ubiquitin-protein ligase CHIP\",\"id\":\"Q9UNE7\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Megakaryocyte-associated tyrosine-protein kinase\",\"id\":\"P42679\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Pro-neuregulin-1, membrane-bound isoform\",\"id\":\"Q02297\"},{\"label\":\"Pro-neuregulin-2, membrane-bound isoform\",\"id\":\"O14511\"},{\"label\":\"Pro-neuregulin-3, membrane-bound isoform\",\"id\":\"P56975\"},{\"label\":\"Pro-neuregulin-4, membrane-bound isoform\",\"id\":\"Q8WWG1\"},{\"label\":\"Probetacellulin\",\"id\":\"P35070\"},{\"label\":\"Proepiregulin\",\"id\":\"O14944\"},{\"label\":\"Proheparin-binding EGF-like growth factor\",\"id\":\"Q99075\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 12\",\"id\":\"Q05209\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 18\",\"id\":\"Q99952\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O14511\",\"O14944\",\"P00533\",\"P01133\",\"P04626\",\"P07900\",\"P0CG47\",\"P0CG48\",\"P35070\",\"P42679\",\"P56975\",\"P62979\",\"P62987\",\"Q02297\",\"Q05209\",\"Q16543\",\"Q8WWG1\",\"Q93034\",\"Q96RT1\",\"Q99075\",\"Q99952\",\"Q9UNE7\"]", "gene_symbol": 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b-c1 complex subunit 7\",\"id\":\"P14927\"},{\"label\":\"Cytochrome b-c1 complex subunit 8\",\"id\":\"O14949\"},{\"label\":\"Cytochrome b-c1 complex subunit 9\",\"id\":\"Q9UDW1\"},{\"label\":\"Cytochrome b-c1 complex subunit Rieske, mitochondrial\",\"id\":\"P47985\"},{\"label\":\"Cytochrome b\",\"id\":\"P00156\"},{\"label\":\"Cytochrome c1, heme protein, mitochondrial\",\"id\":\"P08574\"},{\"label\":\"Frataxin, mitochondrial\",\"id\":\"Q16595\"},{\"label\":\"Iron-sulfur cluster co-chaperone protein HscB\",\"id\":\"Q8IWL3\"},{\"label\":\"LYR motif-containing protein 4\",\"id\":\"Q9HD34\"},{\"label\":\"Mitochondrial chaperone BCS1\",\"id\":\"Q9Y276\"},{\"label\":\"Mitochondrial proton/calcium exchanger protein\",\"id\":\"O95202\"},{\"label\":\"Stress-70 protein, mitochondrial\",\"id\":\"P38646\"},{\"label\":\"Tetratricopeptide repeat protein 19, mitochondrial\",\"id\":\"Q6DKK2\"},{\"label\":\"Ubiquinol-cytochrome c reductase complex assembly factor 1\",\"id\":\"Q9NVA1\"},{\"label\":\"Ubiquinol-cytochrome c reductase complex assembly factor 2\",\"id\":\"Q9BRT2\"},{\"label\":\"Ubiquinol-cytochrome c reductase complex assembly factor 5\",\"id\":\"Q8WVI0\"},{\"label\":\"Ubiquinol-cytochrome c reductase complex assembly factor 6\",\"id\":\"Q69YU5\"},{\"label\":\"Ubiquinol-cytochrome-c reductase complex assembly factor 3\",\"id\":\"Q6UW78\"}]", "uniprot_id": "[\"O14949\",\"O14957\",\"O95202\",\"P00156\",\"P07919\",\"P08574\",\"P14927\",\"P22695\",\"P31930\",\"P38646\",\"P47985\",\"Q16595\",\"Q5U5X0\",\"Q69YU5\",\"Q6DKK2\",\"Q6UW78\",\"Q8IWL3\",\"Q8WVI0\",\"Q9BRT2\",\"Q9HD34\",\"Q9NVA1\",\"Q9UDW1\",\"Q9Y276\"]", "gene_symbol": 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RPB1\",\"id\":\"P24928\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB2\",\"id\":\"P30876\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB3\",\"id\":\"P19387\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB4\",\"id\":\"O15514\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB7\",\"id\":\"P62487\"},{\"label\":\"DNA-directed RNA polymerase II subunit RPB9\",\"id\":\"P36954\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC1\",\"id\":\"P19388\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC2\",\"id\":\"P61218\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC3\",\"id\":\"P52434\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC4\",\"id\":\"P53803\"},{\"label\":\"DNA-directed RNA polymerases I, II, and III subunit RPABC5\",\"id\":\"P62875\"},{\"label\":\"General transcription and DNA repair factor IIH helicase subunit XPD\",\"id\":\"P18074\"},{\"label\":\"General transcription and DNA repair factor IIH helicase/translocase subunit XPB\",\"id\":\"P19447\"},{\"label\":\"General transcription factor IIF subunit 1\",\"id\":\"P35269\"},{\"label\":\"General transcription factor IIF subunit 2\",\"id\":\"P13984\"},{\"label\":\"General transcription factor IIH subunit 1\",\"id\":\"P32780\"},{\"label\":\"General transcription factor IIH subunit 2\",\"id\":\"Q13888\"},{\"label\":\"General transcription factor IIH subunit 3\",\"id\":\"Q13889\"},{\"label\":\"General transcription factor IIH subunit 4\",\"id\":\"Q92759\"},{\"label\":\"General transcription factor IIH subunit 5\",\"id\":\"Q6ZYL4\"},{\"label\":\"Negative elongation factor A\",\"id\":\"Q9H3P2\"},{\"label\":\"Negative elongation factor B\",\"id\":\"Q8WX92\"},{\"label\":\"Negative elongation factor C/D\",\"id\":\"Q8IXH7\"},{\"label\":\"Negative elongation factor E\",\"id\":\"P18615\"},{\"label\":\"Nuclear cap-binding protein subunit 1\",\"id\":\"Q09161\"},{\"label\":\"Nuclear cap-binding protein subunit 2\",\"id\":\"P52298\"},{\"label\":\"RNA polymerase II subunit A C-terminal domain phosphatase\",\"id\":\"Q9Y5B0\"},{\"label\":\"Transcription elongation factor SPT4\",\"id\":\"P63272\"},{\"label\":\"Transcription elongation factor SPT5\",\"id\":\"O00267\"}]", "uniprot_id": "[\"O00267\",\"O15514\",\"P13984\",\"P18074\",\"P18615\",\"P19387\",\"P19388\",\"P19447\",\"P24928\",\"P30876\",\"P32780\",\"P35269\",\"P36954\",\"P50613\",\"P51946\",\"P51948\",\"P52298\",\"P52434\",\"P52435\",\"P53803\",\"P61218\",\"P62487\",\"P62875\",\"P63272\",\"Q09161\",\"Q13888\",\"Q13889\",\"Q6ZYL4\",\"Q8IXH7\",\"Q8WX92\",\"Q92759\",\"Q9H3P2\",\"Q9Y5B0\"]", "gene_symbol": "[\"BTF2\",\"BTF2P44\",\"C6orf175\",\"CAK\",\"CAK1\",\"CAP35\",\"CBP20\",\"CBP80\",\"CCNH\",\"CDK7\",\"CDKN7\",\"COBRA1\",\"CTDP1\",\"ERCC2\",\"ERCC3\",\"FCP1\",\"GTF2F1\",\"GTF2F2\",\"GTF2H1\",\"GTF2H2\",\"GTF2H3\",\"GTF2H4\",\"GTF2H5\",\"KIAA1182\",\"MAT1\",\"MNAT1\",\"MO15\",\"NCBP\",\"NCBP1\",\"NCBP2\",\"NELFA\",\"NELFB\",\"NELFCD\",\"NELFD\",\"NELFE\",\"POLR2\",\"POLR2A\",\"POLR2B\",\"POLR2C\",\"POLR2D\",\"POLR2E\",\"POLR2F\",\"POLR2G\",\"POLR2H\",\"POLR2I\",\"POLR2J\",\"POLR2J1\",\"POLR2K\",\"POLR2L\",\"POLRF\",\"RAP30\",\"RAP74\",\"RD\",\"RDBP\",\"RNF66\",\"RPB7\",\"SPT4H\",\"SPT5\",\"SPT5H\",\"STK1\",\"SUPT4H\",\"SUPT4H1\",\"SUPT5H\",\"TH1\",\"TH1L\",\"TTDA\",\"WHSC2\",\"XPB\",\"XPBC\",\"XPD\",\"XPDC\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "RUNX3 regulates WNT signaling", "protein_name": "[{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"G1/S-specific cyclin-D1\",\"id\":\"P24385\"},{\"label\":\"Lymphoid enhancer-binding factor 1\",\"id\":\"Q9UJU2\"},{\"label\":\"Myc proto-oncogene protein\",\"id\":\"P01106\"},{\"label\":\"Runt-related transcription factor 3\",\"id\":\"Q13761\"},{\"label\":\"Transcription factor 7-like 1\",\"id\":\"Q9HCS4\"},{\"label\":\"Transcription factor 7-like 2\",\"id\":\"Q9NQB0\"},{\"label\":\"Transcription factor 7\",\"id\":\"P36402\"}]", "uniprot_id": "[\"P01106\",\"P24385\",\"P35222\",\"P36402\",\"Q13761\",\"Q9HCS4\",\"Q9NQB0\",\"Q9UJU2\"]", "gene_symbol": "[\"AML2\",\"BCL1\",\"BHLHE39\",\"CBFA3\",\"CCND1\",\"CTNNB\",\"CTNNB1\",\"LEF1\",\"MYC\",\"PEBP2A3\",\"PRAD1\",\"RUNX3\",\"TCF1\",\"TCF3\",\"TCF4\",\"TCF7\",\"TCF7L1\",\"TCF7L2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Maturation of TCA enzymes and regulation of TCA cycle", "protein_name": "[{\"label\":\"Acetyl-CoA acetyltransferase, mitochondrial\",\"id\":\"P24752\"},{\"label\":\"Aconitate hydratase, mitochondrial\",\"id\":\"Q99798\"},{\"label\":\"Citrate synthase, mitochondrial\",\"id\":\"O75390\"},{\"label\":\"Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial\",\"id\":\"A8MUP2\"},{\"label\":\"Frataxin, mitochondrial\",\"id\":\"Q16595\"},{\"label\":\"Iron-sulfur cluster assembly 1 homolog, mitochondrial\",\"id\":\"Q9BUE6\"},{\"label\":\"Iron-sulfur cluster assembly 2 homolog, mitochondrial\",\"id\":\"Q86U28\"},{\"label\":\"Isocitrate dehydrogenase [NADP], mitochondrial\",\"id\":\"P48735\"},{\"label\":\"LYR motif-containing protein 4\",\"id\":\"Q9HD34\"},{\"label\":\"NAD-dependent protein deacetylase sirtuin-3, mitochondrial\",\"id\":\"Q9NTG7\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial\",\"id\":\"O14521\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial\",\"id\":\"P31040\"},{\"label\":\"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial\",\"id\":\"P21912\"},{\"label\":\"Succinate dehydrogenase assembly factor 1, mitochondrial\",\"id\":\"A6NFY7\"},{\"label\":\"Succinate dehydrogenase assembly factor 2, mitochondrial\",\"id\":\"Q9NX18\"},{\"label\":\"Succinate dehydrogenase assembly factor 3, mitochondrial\",\"id\":\"Q9NRP4\"},{\"label\":\"Succinate dehydrogenase assembly factor 4, mitochondrial\",\"id\":\"Q5VUM1\"},{\"label\":\"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial\",\"id\":\"Q99643\"}]", "uniprot_id": "[\"A6NFY7\",\"A8MUP2\",\"O14521\",\"O75390\",\"P21912\",\"P24752\",\"P31040\",\"P48735\",\"Q16595\",\"Q5VUM1\",\"Q86U28\",\"Q99643\",\"Q99798\",\"Q9BUE6\",\"Q9HD34\",\"Q9NRP4\",\"Q9NTG7\",\"Q9NX18\"]", "gene_symbol": "[\"ACAT\",\"ACAT1\",\"ACN9\",\"ACO2\",\"C11orf79\",\"C6orf149\",\"C6orf57\",\"CS\",\"CSKMT\",\"CYB560\",\"FRDA\",\"FXN\",\"HBLD1\",\"HBLD2\",\"IDH2\",\"ISCA1\",\"ISCA2\",\"ISD11\",\"LYRM4\",\"LYRM8\",\"MAT\",\"METTL12\",\"PGL2\",\"SDH\",\"SDH1\",\"SDH2\",\"SDH3\",\"SDH4\",\"SDH5\",\"SDHA\",\"SDHAF1\",\"SDHAF2\",\"SDHAF3\",\"SDHAF4\",\"SDHB\",\"SDHC\",\"SDHD\",\"SDHF\",\"SIR2L3\",\"SIRT3\",\"X25\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "rRNA modification in the nucleus and cytosol", "protein_name": "[{\"label\":\"18S rRNA (guanine-N(7))-methyltransferase\",\"id\":\"O43709\"},{\"label\":\"18S rRNA aminocarboxypropyltransferase\",\"id\":\"Q9UJK0\"},{\"label\":\"28S rRNA (cytosine(4447)-C(5))-methyltransferase\",\"id\":\"P46087\"},{\"label\":\"DDB1- and CUL4-associated factor 13\",\"id\":\"Q9NV06\"},{\"label\":\"Dimethyladenosine transferase\",\"id\":\"Q9UNQ2\"},{\"label\":\"H/ACA ribonucleoprotein complex subunit 1\",\"id\":\"Q9NY12\"},{\"label\":\"H/ACA ribonucleoprotein complex subunit 2\",\"id\":\"Q9NX24\"},{\"label\":\"H/ACA ribonucleoprotein complex subunit 3\",\"id\":\"Q9NPE3\"},{\"label\":\"H/ACA ribonucleoprotein complex subunit DKC1\",\"id\":\"O60832\"},{\"label\":\"HEAT repeat-containing protein 1\",\"id\":\"Q9H583\"},{\"label\":\"KRR1 small subunit processome component homolog\",\"id\":\"Q13601\"},{\"label\":\"Multifunctional methyltransferase subunit TRM112-like protein\",\"id\":\"Q9UI30\"},{\"label\":\"NHP2-like protein 1\",\"id\":\"P55769\"},{\"label\":\"Nucleolar complex protein 4 homolog\",\"id\":\"Q9BVI4\"},{\"label\":\"Nucleolar protein 11\",\"id\":\"Q9H8H0\"},{\"label\":\"Nucleolar protein 14\",\"id\":\"P78316\"},{\"label\":\"Nucleolar protein 56\",\"id\":\"O00567\"},{\"label\":\"Nucleolar protein 58\",\"id\":\"Q9Y2X3\"},{\"label\":\"Nucleolar protein 6\",\"id\":\"Q9H6R4\"},{\"label\":\"Periodic tryptophan protein 2 homolog\",\"id\":\"Q15269\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX47\",\"id\":\"Q9H0S4\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX49\",\"id\":\"Q9Y6V7\"},{\"label\":\"Probable ATP-dependent RNA helicase DDX52\",\"id\":\"Q9Y2R4\"},{\"label\":\"Probable ATP-dependent RNA helicase DHX37\",\"id\":\"Q8IY37\"},{\"label\":\"Probable U3 small nucleolar RNA-associated protein 11\",\"id\":\"Q9Y3A2\"},{\"label\":\"Protein RRP5 homolog\",\"id\":\"Q14690\"},{\"label\":\"RNA 3'-terminal phosphate cyclase-like protein\",\"id\":\"Q9Y2P8\"},{\"label\":\"RNA cytidine acetyltransferase\",\"id\":\"Q9H0A0\"},{\"label\":\"RNA-binding protein PNO1\",\"id\":\"Q9NRX1\"},{\"label\":\"Ribosomal RNA processing protein 36 homolog\",\"id\":\"Q96EU6\"},{\"label\":\"Ribosomal RNA small subunit methyltransferase NEP1\",\"id\":\"Q92979\"},{\"label\":\"Ribosomal RNA-processing protein 7 homolog A\",\"id\":\"Q9Y3A4\"},{\"label\":\"Ribosome biogenesis protein BMS1 homolog\",\"id\":\"Q14692\"},{\"label\":\"Small ribosomal subunit protein eS6\",\"id\":\"P62753\"},{\"label\":\"Small ribosomal subunit protein eS7\",\"id\":\"P62081\"},{\"label\":\"Small ribosomal subunit protein uS11\",\"id\":\"P62263\"},{\"label\":\"Small ribosomal subunit protein uS4\",\"id\":\"P46781\"},{\"label\":\"Small ribosomal subunit protein uS5\",\"id\":\"P15880\"},{\"label\":\"Small subunit processome component 20 homolog\",\"id\":\"O75691\"},{\"label\":\"Something about silencing protein 10\",\"id\":\"Q9NQZ2\"},{\"label\":\"THUMP domain-containing protein 1\",\"id\":\"Q9NXG2\"},{\"label\":\"Transducin beta-like protein 3\",\"id\":\"Q12788\"},{\"label\":\"U3 small nucleolar RNA-associated protein 14 homolog A\",\"id\":\"Q9BVJ6\"},{\"label\":\"U3 small nucleolar RNA-associated protein 14 homolog C\",\"id\":\"Q5TAP6\"},{\"label\":\"U3 small nucleolar RNA-associated protein 15 homolog\",\"id\":\"Q8TED0\"},{\"label\":\"U3 small nucleolar RNA-associated protein 18 homolog\",\"id\":\"Q9Y5J1\"},{\"label\":\"U3 small nucleolar RNA-associated protein 25 homolog\",\"id\":\"Q68CQ4\"},{\"label\":\"U3 small nucleolar RNA-associated protein 4 homolog\",\"id\":\"Q969X6\"},{\"label\":\"U3 small nucleolar RNA-associated protein 6 homolog\",\"id\":\"Q9NYH9\"},{\"label\":\"U3 small nucleolar RNA-interacting protein 2\",\"id\":\"O43818\"},{\"label\":\"U3 small nucleolar ribonucleoprotein protein IMP3\",\"id\":\"Q9NV31\"},{\"label\":\"U3 small nucleolar ribonucleoprotein protein IMP4\",\"id\":\"Q96G21\"},{\"label\":\"U3 small nucleolar ribonucleoprotein protein MPP10\",\"id\":\"O00566\"},{\"label\":\"WD repeat-containing protein 36\",\"id\":\"Q8NI36\"},{\"label\":\"WD repeat-containing protein 3\",\"id\":\"Q9UNX4\"},{\"label\":\"WD repeat-containing protein 43\",\"id\":\"Q15061\"},{\"label\":\"WD repeat-containing protein 46\",\"id\":\"O15213\"},{\"label\":\"WD repeat-containing protein 75\",\"id\":\"Q8IWA0\"},{\"label\":\"rRNA 2'-O-methyltransferase fibrillarin\",\"id\":\"P22087\"},{\"label\":\"rRNA-processing protein FCF1 homolog\",\"id\":\"Q9Y324\"}]", "uniprot_id": 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"gtc_id": "[\"\"]" }, { "pathway_label": "Defective GGT1 causes GLUTH", "protein_name": "[{\"label\":\"Glutathione hydrolase 1 proenzyme\",\"id\":\"P19440\"}]", "uniprot_id": "[\"P19440\"]", "gene_symbol": "[\"GGT\",\"GGT1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TGFBR3 regulates FGF2 signaling", "protein_name": "[{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"PDZ domain-containing protein GIPC1\",\"id\":\"O14908\"},{\"label\":\"Transforming growth factor beta receptor type 3\",\"id\":\"Q03167\"}]", "uniprot_id": "[\"O14908\",\"P09038\",\"Q03167\"]", "gene_symbol": "[\"C19orf3\",\"FGF2\",\"FGFB\",\"GIPC\",\"GIPC1\",\"RGS19IP1\",\"TGFBR3\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-1 processing", "protein_name": "[{\"label\":\"Caspase-1\",\"id\":\"P29466\"},{\"label\":\"Cathepsin G\",\"id\":\"P08311\"},{\"label\":\"Gasdermin-D\",\"id\":\"P57764\"},{\"label\":\"Interleukin-1 alpha\",\"id\":\"P01583\"},{\"label\":\"Interleukin-1 beta\",\"id\":\"P01584\"},{\"label\":\"Interleukin-18\",\"id\":\"Q14116\"},{\"label\":\"Nuclear factor NF-kappa-B p100 subunit\",\"id\":\"Q00653\"},{\"label\":\"Nuclear factor NF-kappa-B p105 subunit\",\"id\":\"P19838\"},{\"label\":\"Transcription factor p65\",\"id\":\"Q04206\"}]", "uniprot_id": "[\"P01583\",\"P01584\",\"P08311\",\"P19838\",\"P29466\",\"P57764\",\"Q00653\",\"Q04206\",\"Q14116\"]", "gene_symbol": "[\"CASP1\",\"CTSG\",\"DFNA5L\",\"GSDMD\",\"GSDMDC1\",\"IGIF\",\"IL18\",\"IL1A\",\"IL1B\",\"IL1BC\",\"IL1BCE\",\"IL1F1\",\"IL1F2\",\"IL1F4\",\"LYT10\",\"NFKB1\",\"NFKB2\",\"NFKB3\",\"RELA\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective F8 cleavage by thrombin", "protein_name": "[{\"label\":\"Coagulation factor VIII\",\"id\":\"P00451\"},{\"label\":\"Prothrombin\",\"id\":\"P00734\"},{\"label\":\"von Willebrand factor\",\"id\":\"P04275\"}]", "uniprot_id": "[\"P00451\",\"P00734\",\"P04275\"]", "gene_symbol": "[\"F2\",\"F8\",\"F8C\",\"F8VWF\",\"VWF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TGFBR3 PTM regulation", "protein_name": "[{\"label\":\"Gamma-secretase subunit APH-1A\",\"id\":\"Q96BI3\"},{\"label\":\"Gamma-secretase subunit APH-1B\",\"id\":\"Q8WW43\"},{\"label\":\"Gamma-secretase subunit PEN-2\",\"id\":\"Q9NZ42\"},{\"label\":\"Matrix metalloproteinase-14\",\"id\":\"P50281\"},{\"label\":\"Matrix metalloproteinase-16\",\"id\":\"P51512\"},{\"label\":\"Metalloproteinase inhibitor 1\",\"id\":\"P01033\"},{\"label\":\"Metalloproteinase inhibitor 2\",\"id\":\"P16035\"},{\"label\":\"Nicastrin\",\"id\":\"Q92542\"},{\"label\":\"Presenilin-1\",\"id\":\"P49768\"},{\"label\":\"Presenilin-2\",\"id\":\"P49810\"},{\"label\":\"Transforming growth factor beta receptor type 3\",\"id\":\"Q03167\"}]", "uniprot_id": "[\"P01033\",\"P16035\",\"P49768\",\"P49810\",\"P50281\",\"P51512\",\"Q03167\",\"Q8WW43\",\"Q92542\",\"Q96BI3\",\"Q9NZ42\"]", "gene_symbol": "[\"AD3\",\"AD4\",\"APH1A\",\"APH1B\",\"C8orf57\",\"CLGI\",\"KIAA0253\",\"MMP14\",\"MMP16\",\"MMPX2\",\"NCSTN\",\"PEN2\",\"PS1\",\"PS2\",\"PSEN1\",\"PSEN2\",\"PSENEN\",\"PSF\",\"PSFL\",\"PSNL1\",\"PSNL2\",\"STM2\",\"TGFBR3\",\"TIMP\",\"TIMP1\",\"TIMP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Resistance of ERBB2 KD mutants to sapitinib", "protein_name": "[{\"label\":\"Erbin\",\"id\":\"Q96RT1\"},{\"label\":\"Heat shock protein HSP 90-alpha\",\"id\":\"P07900\"},{\"label\":\"Hsp90 co-chaperone Cdc37\",\"id\":\"Q16543\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P04626\",\"P07900\",\"Q16543\",\"Q96RT1\"]", "gene_symbol": "[\"CDC37\",\"CDC37A\",\"ERBB2\",\"ERBB2IP\",\"ERBIN\",\"HER2\",\"HSP90A\",\"HSP90AA1\",\"HSPC1\",\"HSPCA\",\"KIAA1225\",\"LAP2\",\"MLN19\",\"NEU\",\"NGL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of apoptosome", "protein_name": "[{\"label\":\"Apoptotic protease-activating factor 1\",\"id\":\"O14727\"},{\"label\":\"Caspase recruitment domain-containing protein 8\",\"id\":\"Q9Y2G2\"},{\"label\":\"Caspase-9\",\"id\":\"P55211\"},{\"label\":\"Cell death regulator Aven\",\"id\":\"Q9NQS1\"},{\"label\":\"Cytochrome c\",\"id\":\"P99999\"},{\"label\":\"Methylthioribulose-1-phosphate dehydratase\",\"id\":\"Q96GX9\"}]", "uniprot_id": "[\"O14727\",\"P55211\",\"P99999\",\"Q96GX9\",\"Q9NQS1\",\"Q9Y2G2\"]", "gene_symbol": "[\"APAF1\",\"APIP\",\"AVEN\",\"CARD8\",\"CASP9\",\"CYC\",\"CYCS\",\"DACAR\",\"KIAA0413\",\"KIAA0955\",\"MCH6\",\"NDPP1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "protein_name": "[{\"label\":\"Calcineurin-binding protein cabin-1\",\"id\":\"Q9Y6J0\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"E1A-binding protein p400\",\"id\":\"Q96L91\"},{\"label\":\"High mobility group protein HMG-I/HMG-Y\",\"id\":\"P17096\"},{\"label\":\"High mobility group protein HMGI-C\",\"id\":\"P52926\"},{\"label\":\"Histone H1.0\",\"id\":\"P07305\"},{\"label\":\"Histone H1.1\",\"id\":\"Q02539\"},{\"label\":\"Histone H1.2\",\"id\":\"P16403\"},{\"label\":\"Histone H1.3\",\"id\":\"P16402\"},{\"label\":\"Histone H1.4\",\"id\":\"P10412\"},{\"label\":\"Histone H1.5\",\"id\":\"P16401\"},{\"label\":\"Histone chaperone ASF1A\",\"id\":\"Q9Y294\"},{\"label\":\"Lamin-B1\",\"id\":\"P20700\"},{\"label\":\"Protein HIRA\",\"id\":\"P54198\"},{\"label\":\"Retinoblastoma-associated protein\",\"id\":\"P06400\"},{\"label\":\"Ubinuclein-1\",\"id\":\"Q9NPG3\"}]", "uniprot_id": "[\"P04637\",\"P06400\",\"P07305\",\"P10412\",\"P16401\",\"P16402\",\"P16403\",\"P17096\",\"P20700\",\"P52926\",\"P54198\",\"Q02539\",\"Q96L91\",\"Q9NPG3\",\"Q9Y294\",\"Q9Y6J0\"]", "gene_symbol": 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Z\",\"id\":\"Q9UBR2\"},{\"label\":\"Chymase\",\"id\":\"P23946\"},{\"label\":\"Glutamyl aminopeptidase\",\"id\":\"Q07075\"},{\"label\":\"Granzyme H\",\"id\":\"P20718\"},{\"label\":\"Liver carboxylesterase 1\",\"id\":\"P23141\"},{\"label\":\"Mast cell carboxypeptidase A\",\"id\":\"P15088\"},{\"label\":\"Neprilysin\",\"id\":\"P08473\"},{\"label\":\"Renin receptor\",\"id\":\"O75787\"},{\"label\":\"Renin\",\"id\":\"P00797\"}]", "uniprot_id": "[\"O75787\",\"P00797\",\"P01019\",\"P07339\",\"P08311\",\"P08473\",\"P12821\",\"P15086\",\"P15088\",\"P15144\",\"P20718\",\"P23141\",\"P23946\",\"Q07075\",\"Q96IY4\",\"Q9BYF1\",\"Q9UBR2\"]", "gene_symbol": "[\"ACE\",\"ACE2\",\"AGT\",\"ANPEP\",\"APN\",\"ATP6AP2\",\"ATP6IP2\",\"CAPER\",\"CD13\",\"CES1\",\"CES2\",\"CGL2\",\"CMA1\",\"CPA3\",\"CPB\",\"CPB1\",\"CPB2\",\"CPSD\",\"CTSD\",\"CTSG\",\"CTSGL2\",\"CTSZ\",\"CYH\",\"CYM\",\"DCP\",\"DCP1\",\"ELDF10\",\"ENPEP\",\"EPN\",\"GZMH\",\"MME\",\"PCPB\",\"PEPN\",\"REN\",\"SERPINA8\",\"SES1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by FGFR2 amplification mutants", "protein_name": "[{\"label\":\"Fibroblast growth factor receptor 2\",\"id\":\"P21802\"}]", "uniprot_id": "[\"P21802\"]", "gene_symbol": "[\"BEK\",\"FGFR2\",\"KGFR\",\"KSAM\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "protein_name": "[{\"label\":\"Catenin beta-1\",\"id\":\"P35222\"},{\"label\":\"Dipeptidyl peptidase 4\",\"id\":\"P27487\"},{\"label\":\"Free fatty acid receptor 1\",\"id\":\"O14842\"},{\"label\":\"Free fatty acid receptor 4\",\"id\":\"Q5NUL3\"},{\"label\":\"Gastrin-releasing peptide\",\"id\":\"P07492\"},{\"label\":\"Glucose-dependent insulinotropic receptor\",\"id\":\"Q8TDV5\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13\",\"id\":\"Q9P2W3\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1\",\"id\":\"P62873\"},{\"label\":\"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3\",\"id\":\"P16520\"},{\"label\":\"Guanine nucleotide-binding protein G(t) subunit alpha-3\",\"id\":\"A8MTJ3\"},{\"label\":\"Homeobox protein CDX-2\",\"id\":\"Q99626\"},{\"label\":\"Leptin\",\"id\":\"P41159\"},{\"label\":\"Neuroendocrine convertase 1\",\"id\":\"P29120\"},{\"label\":\"Paired box protein Pax-6\",\"id\":\"P26367\"},{\"label\":\"Pro-glucagon\",\"id\":\"P01275\"},{\"label\":\"Signal peptidase complex catalytic subunit SEC11A\",\"id\":\"P67812\"},{\"label\":\"Signal peptidase complex catalytic subunit SEC11C\",\"id\":\"Q9BY50\"},{\"label\":\"Signal peptidase complex subunit 1\",\"id\":\"Q9Y6A9\"},{\"label\":\"Signal peptidase complex subunit 2\",\"id\":\"Q15005\"},{\"label\":\"Signal peptidase complex subunit 3\",\"id\":\"P61009\"},{\"label\":\"Transcription factor 7-like 2\",\"id\":\"Q9NQB0\"}]", "uniprot_id": "[\"A8MTJ3\",\"O14842\",\"P01275\",\"P07492\",\"P16520\",\"P26367\",\"P27487\",\"P29120\",\"P35222\",\"P41159\",\"P61009\",\"P62873\",\"P67812\",\"Q15005\",\"Q5NUL3\",\"Q8TDV5\",\"Q99626\",\"Q9BY50\",\"Q9NQB0\",\"Q9P2W3\",\"Q9Y6A9\"]", "gene_symbol": "[\"ADCP2\",\"AN2\",\"CD26\",\"CDX2\",\"CDX3\",\"CTNNB\",\"CTNNB1\",\"DPP4\",\"FFAR1\",\"FFAR4\",\"GCG\",\"GNAT3\",\"GNB1\",\"GNB3\",\"GNG13\",\"GPR119\",\"GPR120\",\"GPR129\",\"GPR40\",\"GRP\",\"KIAA0102\",\"LEP\",\"NEC1\",\"O3FAR1\",\"OB\",\"OBS\",\"PAX6\",\"PCSK1\",\"PGR4\",\"SEC11A\",\"SEC11C\",\"SEC11L1\",\"SEC11L3\",\"SPC12\",\"SPC18\",\"SPC21\",\"SPC22\",\"SPC25\",\"SPCS1\",\"SPCS2\",\"SPCS3\",\"SPCS4A\",\"SPCS4C\",\"TCF4\",\"TCF7L2\"]", "gtc_id": "[\"G58161NS\"]" }, { "pathway_label": "Toll Like Receptor 7/8 (TLR7/8) Cascade", "protein_name": "[{\"label\":\"Toll-like receptor 7\",\"id\":\"Q9NYK1\"},{\"label\":\"Toll-like receptor 8\",\"id\":\"Q9NR97\"}]", "uniprot_id": "[\"Q9NR97\",\"Q9NYK1\"]", "gene_symbol": "[\"TLR7\",\"TLR8\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Axonal growth inhibition (RHOA activation)", "protein_name": "[{\"label\":\"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1\",\"id\":\"Q96FE5\"},{\"label\":\"Myelin-associated glycoprotein\",\"id\":\"P20916\"},{\"label\":\"Oligodendrocyte-myelin glycoprotein\",\"id\":\"P23515\"},{\"label\":\"Proto-oncogene DBL\",\"id\":\"P10911\"},{\"label\":\"Reticulon-4\",\"id\":\"Q9NQC3\"},{\"label\":\"Rho GDP-dissociation inhibitor 1\",\"id\":\"P52565\"},{\"label\":\"Transforming protein RhoA\",\"id\":\"P61586\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 16\",\"id\":\"P08138\"}]", "uniprot_id": "[\"P08138\",\"P10911\",\"P20916\",\"P23515\",\"P52565\",\"P61586\",\"Q96FE5\",\"Q9NQC3\"]", "gene_symbol": "[\"ARH12\",\"ARHA\",\"ARHGDIA\",\"DBL\",\"GDIA1\",\"GMA\",\"KIAA0886\",\"LERN1\",\"LINGO1\",\"LRRN6A\",\"MAG\",\"MCF2\",\"NGFR\",\"NOGO\",\"OMG\",\"OMGP\",\"RHO12\",\"RHOA\",\"RTN4\",\"TNFRSF16\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Maturation of protein E", "protein_name": "[{\"label\":\"Envelope small membrane protein\",\"id\":\"P59637\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"P0CG47\",\"P0CG48\",\"P59637\",\"P62979\",\"P62987\"]", "gene_symbol": "[\"E\",\"RPS27A\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\",\"sM\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signaling by extracellular domain mutants of KIT", "protein_name": "[{\"label\":\"Mast/stem cell growth factor receptor Kit\",\"id\":\"P10721\"}]", "uniprot_id": "[\"P10721\"]", "gene_symbol": "[\"KIT\",\"SCFR\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Bloch pathway", "protein_name": "[{\"label\":\"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase\",\"id\":\"Q15125\"},{\"label\":\"7-dehydrocholesterol reductase\",\"id\":\"Q9UBM7\"},{\"label\":\"Delta(24)-sterol reductase\",\"id\":\"Q15392\"},{\"label\":\"Lathosterol oxidase\",\"id\":\"O75845\"}]", "uniprot_id": "[\"O75845\",\"Q15125\",\"Q15392\",\"Q9UBM7\"]", "gene_symbol": "[\"D7SR\",\"DHCR24\",\"DHCR7\",\"EBP\",\"KIAA0018\",\"SC5D\",\"SC5DL\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "NTF4 activates NTRK2 (TRKB) signaling", "protein_name": "[{\"label\":\"BDNF/NT-3 growth factors receptor\",\"id\":\"Q16620\"},{\"label\":\"Neurotrophin-4\",\"id\":\"P34130\"}]", "uniprot_id": "[\"P34130\",\"Q16620\"]", "gene_symbol": "[\"NTF4\",\"NTF5\",\"NTRK2\",\"TRKB\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Synthesis of IP2, IP, and Ins in the cytosol", "protein_name": "[{\"label\":\"Inositol monophosphatase 1\",\"id\":\"P29218\"},{\"label\":\"Inositol monophosphatase 2\",\"id\":\"O14732\"},{\"label\":\"Inositol oxygenase\",\"id\":\"Q9UGB7\"},{\"label\":\"Inositol polyphosphate 1-phosphatase\",\"id\":\"P49441\"},{\"label\":\"Inositol polyphosphate 4-phosphatase type II\",\"id\":\"O15327\"},{\"label\":\"Inositol polyphosphate 5-phosphatase OCRL\",\"id\":\"Q01968\"},{\"label\":\"Inositol polyphosphate-4-phosphatase type I A\",\"id\":\"Q96PE3\"},{\"label\":\"Inositol polyphosphate-5-phosphatase A\",\"id\":\"Q14642\"},{\"label\":\"Inositol-3-phosphate synthase 1\",\"id\":\"Q9NPH2\"},{\"label\":\"Myotubularin-related protein 9\",\"id\":\"Q96QG7\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A\",\"id\":\"Q15735\"},{\"label\":\"Phosphatidylinositol-3-phosphate phosphatase MTMR7\",\"id\":\"Q9Y216\"},{\"label\":\"Synaptojanin-1\",\"id\":\"O43426\"},{\"label\":\"Type II inositol 1,4,5-trisphosphate 5-phosphatase\",\"id\":\"P32019\"}]", "uniprot_id": 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core protein\",\"id\":\"O14594\"},{\"label\":\"Uronyl 2-sulfotransferase\",\"id\":\"Q9Y2C2\"},{\"label\":\"Versican core protein\",\"id\":\"P13611\"}]", "uniprot_id": "[\"O14594\",\"O95196\",\"P07585\",\"P13611\",\"P21810\",\"Q6UVK1\",\"Q8IZU8\",\"Q8NCH0\",\"Q96GW7\",\"Q9UL01\",\"Q9Y2C2\"]", "gene_symbol": "[\"BCAN\",\"BEHAB\",\"BGN\",\"C18orf4\",\"CALEB\",\"CHST14\",\"CSPG2\",\"CSPG3\",\"CSPG4\",\"CSPG5\",\"CSPG7\",\"D4ST1\",\"DCN\",\"DS2ST\",\"DSE\",\"DSEL\",\"MCSP\",\"NCAG1\",\"NCAN\",\"NEUR\",\"NGC\",\"SART2\",\"SLRR1A\",\"SLRR1B\",\"UST\",\"VCAN\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Interleukin-9 signaling", "protein_name": "[{\"label\":\"Cytokine receptor common subunit gamma\",\"id\":\"P31785\"},{\"label\":\"Interleukin-9 receptor\",\"id\":\"Q01113\"},{\"label\":\"Interleukin-9\",\"id\":\"P15248\"},{\"label\":\"Signal transducer and activator of transcription 1-alpha/beta\",\"id\":\"P42224\"},{\"label\":\"Signal transducer and activator of transcription 3\",\"id\":\"P40763\"},{\"label\":\"Signal transducer and activator of transcription 5A\",\"id\":\"P42229\"},{\"label\":\"Signal transducer and activator of transcription 5B\",\"id\":\"P51692\"},{\"label\":\"Tyrosine-protein kinase JAK1\",\"id\":\"P23458\"},{\"label\":\"Tyrosine-protein kinase JAK3\",\"id\":\"P52333\"}]", "uniprot_id": "[\"P15248\",\"P23458\",\"P31785\",\"P40763\",\"P42224\",\"P42229\",\"P51692\",\"P52333\",\"Q01113\"]", "gene_symbol": "[\"APRF\",\"IL2RG\",\"IL9\",\"IL9R\",\"JAK1\",\"JAK1A\",\"JAK1B\",\"JAK3\",\"STAT1\",\"STAT3\",\"STAT5\",\"STAT5A\",\"STAT5B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Signal transduction by L1", "protein_name": "[{\"label\":\"Casein kinase II subunit alpha'\",\"id\":\"P19784\"},{\"label\":\"Casein kinase II subunit alpha\",\"id\":\"P68400\"},{\"label\":\"Casein kinase II subunit beta\",\"id\":\"P67870\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 1\",\"id\":\"Q02750\"},{\"label\":\"Dual specificity mitogen-activated protein kinase kinase 2\",\"id\":\"P36507\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Guanine nucleotide exchange factor VAV2\",\"id\":\"P52735\"},{\"label\":\"Integrin alpha-5\",\"id\":\"P08648\"},{\"label\":\"Integrin alpha-9\",\"id\":\"Q13797\"},{\"label\":\"Integrin alpha-IIb\",\"id\":\"P08514\"},{\"label\":\"Integrin alpha-V\",\"id\":\"P06756\"},{\"label\":\"Integrin beta-1\",\"id\":\"P05556\"},{\"label\":\"Integrin beta-3\",\"id\":\"P05106\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Neural cell adhesion molecule 1\",\"id\":\"P13591\"},{\"label\":\"Neural cell adhesion molecule L1\",\"id\":\"P32004\"},{\"label\":\"Neuropilin-1\",\"id\":\"O14786\"},{\"label\":\"Ras-related C3 botulinum toxin substrate 1\",\"id\":\"P63000\"},{\"label\":\"Serine/threonine-protein kinase PAK 1\",\"id\":\"Q13153\"}]", "uniprot_id": 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B1\",\"id\":\"P09429\"},{\"label\":\"Mitogen-activated protein kinase 1\",\"id\":\"P28482\"},{\"label\":\"Mitogen-activated protein kinase 3\",\"id\":\"P27361\"},{\"label\":\"Protein S100-A12\",\"id\":\"P80511\"},{\"label\":\"Protein S100-B\",\"id\":\"P04271\"},{\"label\":\"Serum amyloid A-1 protein\",\"id\":\"P0DJI8\"}]", "uniprot_id": "[\"P04271\",\"P05067\",\"P09429\",\"P0DJI8\",\"P14314\",\"P17931\",\"P27361\",\"P28482\",\"P39656\",\"P47755\",\"P52907\",\"P80511\",\"Q15109\"]", "gene_symbol": "[\"A4\",\"AD1\",\"AGER\",\"APP\",\"CAPZA1\",\"CAPZA2\",\"DDOST\",\"ERK1\",\"ERK2\",\"G19P1\",\"HMG1\",\"HMGB1\",\"KIAA0115\",\"LGALS3\",\"MAC2\",\"MAPK1\",\"MAPK3\",\"OST48\",\"PRKCSH\",\"PRKM1\",\"PRKM2\",\"PRKM3\",\"RAGE\",\"S100A12\",\"S100B\",\"SAA1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Biosynthesis of protectins", "protein_name": "[{\"label\":\"Cytochrome P450 1A1\",\"id\":\"P04798\"},{\"label\":\"Cytochrome P450 1A2\",\"id\":\"P05177\"},{\"label\":\"Leukotriene A-4 hydrolase\",\"id\":\"P09960\"},{\"label\":\"Polyunsaturated fatty acid lipoxygenase ALOX15\",\"id\":\"P16050\"}]", "uniprot_id": "[\"P04798\",\"P05177\",\"P09960\",\"P16050\"]", "gene_symbol": "[\"ALOX15\",\"CYP1A1\",\"CYP1A2\",\"LOG15\",\"LTA4\",\"LTA4H\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)", "protein_name": "[{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit epsilon\",\"id\":\"Q14164\"},{\"label\":\"Interferon regulatory factor 3\",\"id\":\"Q14653\"},{\"label\":\"Interferon regulatory factor 7\",\"id\":\"Q92985\"},{\"label\":\"Lymphocyte antigen 96\",\"id\":\"Q9Y6Y9\"},{\"label\":\"Monocyte differentiation antigen CD14\",\"id\":\"P08571\"},{\"label\":\"Optineurin\",\"id\":\"Q96CV9\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Serine/threonine-protein kinase TBK1\",\"id\":\"Q9UHD2\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"TIR domain-containing adapter molecule 2\",\"id\":\"Q86XR7\"},{\"label\":\"TNF receptor-associated factor 3\",\"id\":\"Q13114\"},{\"label\":\"TRAF family member-associated NF-kappa-B activator\",\"id\":\"Q92844\"},{\"label\":\"Toll-like receptor 4\",\"id\":\"O00206\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O00206\",\"P08571\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q06124\",\"Q13114\",\"Q14164\",\"Q14653\",\"Q86XR7\",\"Q8IUC6\",\"Q92844\",\"Q92985\",\"Q96CV9\",\"Q9UHD2\",\"Q9Y6Y9\"]", "gene_symbol": 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Sp1\",\"id\":\"P08047\"},{\"label\":\"Zinc finger E-box-binding homeobox 2\",\"id\":\"O60315\"},{\"label\":\"Zinc finger protein SNAI1\",\"id\":\"O95863\"}]", "uniprot_id": "[\"O60315\",\"O95863\",\"P08047\",\"P31273\",\"Q12906\",\"Q12946\",\"Q8NFJ8\",\"Q9NQ87\",\"Q9NQV8\"]", "gene_symbol": "[\"BHLHB33\",\"BHLHB5\",\"BHLHE22\",\"DRBF\",\"FKHL5\",\"FOXF1\",\"FREAC1\",\"HEYL\",\"HOX3A\",\"HOXC8\",\"HRT3\",\"ILF3\",\"KIAA0569\",\"MPHOSPH4\",\"NF90\",\"PFM5\",\"PRDM8\",\"SIP1\",\"SNAH\",\"SNAI1\",\"SP1\",\"TNRC20\",\"TSFP1\",\"ZEB2\",\"ZFHX1B\",\"ZFX1B\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PLCG1 events in ERBB2 signaling", "protein_name": "[{\"label\":\"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1\",\"id\":\"P19174\"},{\"label\":\"Epidermal growth factor receptor\",\"id\":\"P00533\"},{\"label\":\"Pro-epidermal growth factor\",\"id\":\"P01133\"},{\"label\":\"Receptor tyrosine-protein kinase erbB-2\",\"id\":\"P04626\"}]", "uniprot_id": "[\"P00533\",\"P01133\",\"P04626\",\"P19174\"]", "gene_symbol": "[\"EGF\",\"EGFR\",\"ERBB\",\"ERBB1\",\"ERBB2\",\"HER1\",\"HER2\",\"MLN19\",\"NEU\",\"NGL\",\"PLC1\",\"PLCG1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA", "protein_name": "[{\"label\":\"Enoyl-CoA hydratase, mitochondrial\",\"id\":\"P30084\"},{\"label\":\"Enoyl-[acyl-carrier-protein] reductase, mitochondrial\",\"id\":\"Q9BV79\"},{\"label\":\"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial\",\"id\":\"Q16836\"},{\"label\":\"Medium-chain specific acyl-CoA dehydrogenase, mitochondrial\",\"id\":\"P11310\"},{\"label\":\"Trifunctional enzyme subunit alpha, mitochondrial\",\"id\":\"P40939\"},{\"label\":\"Trifunctional enzyme subunit beta, mitochondrial\",\"id\":\"P55084\"}]", "uniprot_id": "[\"P11310\",\"P30084\",\"P40939\",\"P55084\",\"Q16836\",\"Q9BV79\"]", "gene_symbol": "[\"ACADM\",\"ECHS1\",\"HAD\",\"HAD1\",\"HADH\",\"HADHA\",\"HADHB\",\"HADHSC\",\"MECR\",\"NBRF1\",\"SCHAD\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Defective BTD causes biotidinase deficiency", "protein_name": "[{\"label\":\"Biotinidase\",\"id\":\"P43251\"}]", "uniprot_id": "[\"P43251\"]", "gene_symbol": "[\"BTD\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "PI-3K cascade:FGFR3", "protein_name": "[{\"label\":\"Fibroblast growth factor 16\",\"id\":\"O43320\"},{\"label\":\"Fibroblast growth factor 18\",\"id\":\"O76093\"},{\"label\":\"Fibroblast growth factor 1\",\"id\":\"P05230\"},{\"label\":\"Fibroblast growth factor 20\",\"id\":\"Q9NP95\"},{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"},{\"label\":\"Fibroblast growth factor 2\",\"id\":\"P09038\"},{\"label\":\"Fibroblast growth factor 4\",\"id\":\"P08620\"},{\"label\":\"Fibroblast growth factor 9\",\"id\":\"P31371\"},{\"label\":\"Fibroblast growth factor receptor substrate 2\",\"id\":\"Q8WU20\"},{\"label\":\"GRB2-associated-binding protein 1\",\"id\":\"Q13480\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"}]", "uniprot_id": "[\"O43320\",\"O76093\",\"P05230\",\"P08620\",\"P09038\",\"P27986\",\"P31371\",\"P42336\",\"Q06124\",\"Q13480\",\"Q8WU20\",\"Q9GZV9\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF16\",\"FGF18\",\"FGF2\",\"FGF20\",\"FGF23\",\"FGF4\",\"FGF9\",\"FGFA\",\"FGFB\",\"FRS2\",\"GAB1\",\"GRB1\",\"HST\",\"HSTF1\",\"HYPF\",\"KS3\",\"PIK3CA\",\"PIK3R1\",\"PTP2C\",\"PTPN11\",\"SHPTP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "FGFR1c and Klotho ligand binding and activation", "protein_name": "[{\"label\":\"Fibroblast growth factor 23\",\"id\":\"Q9GZV9\"}]", "uniprot_id": "[\"Q9GZV9\"]", "gene_symbol": "[\"FGF23\",\"HYPF\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Loss of function of TP53 in cancer due to loss of tetramerization ability", "protein_name": "[{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"}]", "uniprot_id": "[\"P04637\"]", "gene_symbol": "[\"P53\",\"TP53\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "TICAM1-dependent activation of IRF3/IRF7", "protein_name": "[{\"label\":\"Inhibitor of nuclear factor kappa-B kinase subunit epsilon\",\"id\":\"Q14164\"},{\"label\":\"Interferon regulatory factor 3\",\"id\":\"Q14653\"},{\"label\":\"Interferon regulatory factor 7\",\"id\":\"Q92985\"},{\"label\":\"Optineurin\",\"id\":\"Q96CV9\"},{\"label\":\"Polyubiquitin-B\",\"id\":\"P0CG47\"},{\"label\":\"Polyubiquitin-C\",\"id\":\"P0CG48\"},{\"label\":\"Serine/threonine-protein kinase TBK1\",\"id\":\"Q9UHD2\"},{\"label\":\"TIR domain-containing adapter molecule 1\",\"id\":\"Q8IUC6\"},{\"label\":\"TNF receptor-associated factor 3\",\"id\":\"Q13114\"},{\"label\":\"TRAF family member-associated NF-kappa-B activator\",\"id\":\"Q92844\"},{\"label\":\"Toll-like receptor 3\",\"id\":\"O15455\"},{\"label\":\"Ubiquitin-ribosomal protein eL40 fusion protein\",\"id\":\"P62987\"},{\"label\":\"Ubiquitin-ribosomal protein eS31 fusion protein\",\"id\":\"P62979\"}]", "uniprot_id": "[\"O15455\",\"P0CG47\",\"P0CG48\",\"P62979\",\"P62987\",\"Q13114\",\"Q14164\",\"Q14653\",\"Q8IUC6\",\"Q92844\",\"Q92985\",\"Q96CV9\",\"Q9UHD2\"]", "gene_symbol": "[\"CAP-1\",\"CRAF1\",\"FIP2\",\"GLC1E\",\"HIP7\",\"HYPL\",\"IKBKE\",\"IKKE\",\"IKKI\",\"IRF3\",\"IRF7\",\"ITRAF\",\"KIAA0151\",\"NAK\",\"NRP\",\"OPTN\",\"PRVTIRB\",\"RPS27A\",\"TANK\",\"TBK1\",\"TICAM1\",\"TLR3\",\"TRAF2\",\"TRAF3\",\"TRAFAMN\",\"TRIF\",\"UBA52\",\"UBA80\",\"UBB\",\"UBC\",\"UBCEP1\",\"UBCEP2\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Factors involved in megakaryocyte development and platelet production", "protein_name": "[{\"label\":\"A-kinase anchor protein 1, mitochondrial\",\"id\":\"Q92667\"},{\"label\":\"A-kinase anchor protein 10, mitochondrial\",\"id\":\"O43572\"},{\"label\":\"CDK5 and ABL1 enzyme substrate 1\",\"id\":\"Q8TDN4\"},{\"label\":\"CDK5 and ABL1 enzyme substrate 2\",\"id\":\"Q9BTV7\"},{\"label\":\"Cell division control protein 42 homolog\",\"id\":\"P60953\"},{\"label\":\"Cellular tumor antigen p53\",\"id\":\"P04637\"},{\"label\":\"Chromobox protein homolog 5\",\"id\":\"P45973\"},{\"label\":\"Cyclin-dependent kinase 2\",\"id\":\"P24941\"},{\"label\":\"Cyclin-dependent kinase 5\",\"id\":\"Q00535\"},{\"label\":\"DNA repair protein RAD51 homolog 2\",\"id\":\"O15315\"},{\"label\":\"DNA repair protein RAD51 homolog 3\",\"id\":\"O43502\"},{\"label\":\"Dedicator of cytokinesis protein 10\",\"id\":\"Q96BY6\"},{\"label\":\"Dedicator of cytokinesis protein 11\",\"id\":\"Q5JSL3\"},{\"label\":\"Dedicator of cytokinesis protein 1\",\"id\":\"Q14185\"},{\"label\":\"Dedicator of cytokinesis protein 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"gtc_id": "[\"\"]" }, { "pathway_label": "Costimulation by the CD28 family", "protein_name": "[{\"label\":\"B- and T-lymphocyte attenuator\",\"id\":\"Q7Z6A9\"},{\"label\":\"ICOS ligand\",\"id\":\"O75144\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit alpha\",\"id\":\"P27986\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit beta\",\"id\":\"O00459\"},{\"label\":\"Phosphatidylinositol 3-kinase regulatory subunit gamma\",\"id\":\"Q92569\"},{\"label\":\"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform\",\"id\":\"P42336\"},{\"label\":\"Tumor necrosis factor receptor superfamily member 14\",\"id\":\"Q92956\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 11\",\"id\":\"Q06124\"},{\"label\":\"Tyrosine-protein phosphatase non-receptor type 6\",\"id\":\"P29350\"}]", "uniprot_id": "[\"O00459\",\"O75144\",\"P27986\",\"P29350\",\"P42336\",\"Q06124\",\"Q7Z6A9\",\"Q92569\",\"Q92956\"]", "gene_symbol": 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NRas\",\"id\":\"P01111\"},{\"label\":\"Son of sevenless homolog 1\",\"id\":\"Q07889\"}]", "uniprot_id": "[\"O15520\",\"P01111\",\"P01112\",\"P05230\",\"P08620\",\"P09038\",\"P10767\",\"P11487\",\"P31371\",\"Q07889\",\"Q9GZV9\",\"Q9HCT0\",\"Q9NP95\"]", "gene_symbol": "[\"FGF1\",\"FGF10\",\"FGF2\",\"FGF20\",\"FGF22\",\"FGF23\",\"FGF3\",\"FGF4\",\"FGF6\",\"FGF9\",\"FGFA\",\"FGFB\",\"HRAS\",\"HRAS1\",\"HST\",\"HST2\",\"HSTF1\",\"HSTF2\",\"HYPF\",\"INT2\",\"KS3\",\"NRAS\",\"SOS1\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "GLI proteins bind promoters of Hh responsive genes to promote transcription", "protein_name": "[{\"label\":\"Transcriptional activator GLI3\",\"id\":\"P10071\"},{\"label\":\"Zinc finger protein GLI1\",\"id\":\"P08151\"},{\"label\":\"Zinc finger protein GLI2\",\"id\":\"P10070\"}]", "uniprot_id": "[\"P08151\",\"P10070\",\"P10071\"]", "gene_symbol": "[\"GLI\",\"GLI1\",\"GLI2\",\"GLI3\",\"THP\"]", "gtc_id": "[\"\"]" }, { "pathway_label": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)", "protein_name": "[{\"label\":\"Eukaryotic peptide chain release factor GTP-binding subunit ERF3A\",\"id\":\"P15170\"},{\"label\":\"Eukaryotic peptide chain release factor GTP-binding subunit ERF3B\",\"id\":\"Q8IYD1\"},{\"label\":\"Eukaryotic peptide chain release factor subunit 1\",\"id\":\"P62495\"},{\"label\":\"Eukaryotic translation initiation factor 4 gamma 1\",\"id\":\"Q04637\"},{\"label\":\"Large ribosomal subunit protein P1\",\"id\":\"P05386\"},{\"label\":\"Large ribosomal subunit protein P2\",\"id\":\"P05387\"},{\"label\":\"Large ribosomal subunit protein eL13\",\"id\":\"P26373\"},{\"label\":\"Large ribosomal subunit protein eL14\",\"id\":\"P50914\"},{\"label\":\"Large ribosomal subunit protein eL15\",\"id\":\"P61313\"},{\"label\":\"Large ribosomal subunit protein eL18\",\"id\":\"Q07020\"},{\"label\":\"Large ribosomal subunit protein eL19\",\"id\":\"P84098\"},{\"label\":\"Large ribosomal subunit protein 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eL38\",\"id\":\"P63173\"},{\"label\":\"Large ribosomal subunit protein eL39\",\"id\":\"P62891\"},{\"label\":\"Large ribosomal subunit protein eL42\",\"id\":\"P83881\"},{\"label\":\"Large ribosomal subunit protein eL43\",\"id\":\"P61513\"},{\"label\":\"Large ribosomal subunit protein eL6\",\"id\":\"Q02878\"},{\"label\":\"Large ribosomal subunit protein eL8\",\"id\":\"P62424\"},{\"label\":\"Large ribosomal subunit protein uL10\",\"id\":\"P05388\"},{\"label\":\"Large ribosomal subunit protein uL11\",\"id\":\"P30050\"},{\"label\":\"Large ribosomal subunit protein uL13\",\"id\":\"P40429\"},{\"label\":\"Large ribosomal subunit protein uL14\",\"id\":\"P62829\"},{\"label\":\"Large ribosomal subunit protein uL15\",\"id\":\"P46776\"},{\"label\":\"Large ribosomal subunit protein uL16\",\"id\":\"P27635\"},{\"label\":\"Large ribosomal subunit protein uL18\",\"id\":\"P46777\"},{\"label\":\"Large ribosomal subunit protein uL1\",\"id\":\"P62906\"},{\"label\":\"Large ribosomal subunit protein 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