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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature ▲ | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Escherichia coli | PrsG (class III) G adhesins | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | Acute cystitis patients | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | |
| Escherichia coli | PapG (class I) | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | Human erythrocytes | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9673272 |
| Burkholderia cepacia | Lectin-like proteins (adhesin) | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Sputa of cystic fibrosis patients | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 8606110 |
| Escherichia coli | Pyelonephritic adhesins | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | Kidney | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 18809496 |
| Streptococcus pneumoniae | Adhesins | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Type-II lung cells, Vascular endothelial cells | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7752878 |
| Streptococcus pneumoniae | Adhesins | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | Type-II lung cells, Vascular endothelial cells | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7752878 |
| Streptococcus pneumoniae | Adhesins | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | Type-II lung cells, Vascular endothelial cells | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7752878 |
| Streptococcus suis | Adhesins | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | Erythrocytes | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7961660 |
| Streptococcus pneumoniae | CBPs (choline-binding proteins) | nLc4Cer (Neolactotetraosylceramide; Paragloboside) | Oligoglycosylceramides | Cytokine-activated cells | Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 12640357 |
| Burkholderia pseudomallei | Adhesins | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Pharyngeal epithelial cells | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 10497993 |
| Escherichia coli | P-fimbriae | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | Acute cystitis patients | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | |
| Escherichia coli | P-fimbriae | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | Human erythrocytes | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9673272 |
| Moraxella catarrhalis | Fimbriae | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Other than pharyngeal epithelial cells | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 12137200 |
| Candida albicans | 66-kDa subunit | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Human buccal epihelial cells (BECs) | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 8005674 |
| Pseudomonas aeruginosa | Type 4-pili | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Epithelial cells | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9224879 |
| Escherichia coli | P-pili | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | Epithelial cells in human urinary tract | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9007266 |
| Escherichia coli | Verotoxin (1; B-subunit) | CD77 (Globotriaosylceramide; Gb3) | Oligoglycosylceramides | Germinal center B lymphocytes, Burkitt's lymphoma cells | Gal(a1-4)Gal | Binding | 7516406 |
| Streptococcus pneumoniae | Unknown | nLc4Cer (Neolactotetraosylceramide; Paragloboside) | Oligoglycosylceramides | Chinchilla tracheal epithelium | Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 10090858 |
| Neisseria gonorrhoeae | 36-kDa proteins | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 2115881 |
| Propionibacterium granulosum | Unknown | isoGb3 (Isoglobotriaosylceramide; iGb3) | Oligoglycosylceramides | Whole dog small intestine | Gal(a1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 2452754 |
| Helicobacter pylori | 35S-labeled or 125I-labeled proteins | isoGb3 (Isoglobotriaosylceramide; iGb3) | Oligoglycosylceramides | Dog small intestine | Gal(a1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 9499377 |
| Helicobacter pylori | 35S-labeled or 125I-labeled proteins | Fucosyl Asialo GM1 | Oligoglycosylceramides | Mouse small intestine | Fuc(a1-2)Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9499377 |
| Helicobacter pylori | 35S-labeled or 125I-labeled proteins | Asialo-GM2 (Gangliotriosylceramide; GgO3) | Oligoglycosylceramides | Guinea pig erythrocytes | GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9499377 |
| Escherichia coli | PapG (class II) | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | Human erythrocytes | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9673272 |
| Neisseria gonorrhoeae | Adhesins | nLc4Cer (Neolactotetraosylceramide; Paragloboside) | Oligoglycosylceramides | Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva | Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 2115881 |
