GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **26 - 50** of **263** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	GTP-binding protein Par-6 family cell polarity regulator alpha Polyubiquitin-B Protein kinase C TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein	A0A1D5P546 E1BQN6 F1P0U8 H9CX01 O93467 P0CG62 P79781 Q06900 Q90999	ChALK5 PARD6A PRKCZ RHOA RPS27A TGFB1 TGFBR1 TGFBR2 UBA80 UBB cRhoA rhoA	Gallus gallus (chicken)
TGF-beta receptor signaling activates SMADs	Integrin beta Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta receptor 3 Transforming growth factor beta Transforming growth factor beta Zinc finger FYVE domain-containing protein furin peptidylprolyl isomerase	A0A1D5NUH3 E1C6T3 F1NNP2 H9CX01 P84023 Q06900 Q8UWF3 Q90998 Q90999 Q90ZG0 Q91000 Q92071	ChALK5 FKBP12 FURIN ITGB3 LOC769000 MADH2 MADH3 SMAD3 TGFB1 TGFB2 TGFBR1 TGFBR2 TGFBR3 ZFYVE9	Gallus gallus (chicken)
TFAP2 (AP-2) family regulates transcription of cell cycle factors	Lysine-specific demethylase 5B Myc proto-oncogene protein Transcription factor AP-2 gamma	E1C5K7 P01109 Q5F3R2	JARID1B KDM5B MYC TFAP2C	Gallus gallus (chicken)
TCF dependent signaling in response to WNT	Axin 2 Axin-1 Catenin beta-1 Polyubiquitin-B Protein Wnt-3a Protein Wnt Protein Wnt Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein ubiquitinyl hydrolase 1	A0A1D5NYE8 A0A1D5P395 A0A1D5P546 A0A1D5PPH8 A0A3Q2TX44 A1DYI3 P0CG62 P79781 Q2LMP1 Q9YGX6	AXIN1 AXIN2 CTNNB1 RPS27A UBA80 UBB USP34 WNT3 WNT3A WNT5A Wnt3	Gallus gallus (chicken)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Dipeptidyl peptidase 4 G protein subunit alpha transducin 3 G protein subunit beta 3 G protein subunit gamma 13 G protein-coupled receptor 119 Gastrin-releasing peptide Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Pro-glucagon	A0A1D5P7Z5 A0A1D5PJA5 E1C1U6 F1NLV4 F1P3R0 M9NJI3 P01295 P68259	DPP4 GCG GNAT3 GNB1 GNB3 GNG13 GPR119 GRP	Gallus gallus (chicken)	G58161NS
Synthesis, secretion, and deacylation of Ghrelin	Appetite-regulating hormone Insulin-like growth factor I Insulin Pro-glucagon Signal peptidase complex catalytic subunit SEC11 Signal peptidase complex subunit 3 Somatotropin	P08998 P18254 P28687 P67970 P68259 Q5ZMQ3 Q8AV73	GCG GH GHRL IGF1 INS SEC11A SPC22 SPCS3 ghr ghre	Gallus gallus (chicken)	G58161NS
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Hematopoietic prostaglandin D synthase Prostaglandin E synthase Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2	A0A1D5PM03 E2IPN6 O73888 P27607	CEF-147 GSTS HPGDS PGDS PTGDS2 PTGES PTGS1 PTGS2	Gallus gallus (chicken)
Synthesis of PC	Abhydrolase domain containing 3, phospholipase Choline O-acetyltransferase Choline transporter-like protein Choline/ethanolaminephosphotransferase 1 Cholinephosphotransferase 1 Sodium-dependent lysophosphatidylcholine symporter 1 ethanolamine kinase	A0A1D5P2G3 A0A3Q3AVJ7 F1NCD6 F1NT05 F1NTP8 F1P393 Q5ZHQ5	ABHD3 CEPT1 CHAT CHKA CHPT1 MFSD2A NLS1 SLC44A5	Gallus gallus (chicken)
Synthesis of 15-eicosatetraenoic acid derivatives	Hydroperoxide isomerase ALOXE3 Prostaglandin G/H synthase 2	A0A1L1RTQ1 P27607	ALOX15B CEF-147 PTGS2	Gallus gallus (chicken)
Syndecan interactions	Fibroblast growth factor 2 Integrin beta Protein kinase C Syndecan-4 Syndecan Syndecan Transforming growth factor beta	F1NV24 H9CX01 P48800 P49416 Q8JIY0 Q92071 R4GHL2	FGF2 ITGB3 PRKCA SDC1 SDC2 SDC4 TGFB1	Gallus gallus (chicken)
Surfactant metabolism	Adenosine receptor A2b Adrenoceptor alpha 2C Alpha-2A adrenergic receptor LIM and cysteine rich domains 1 Lung lectin Sodium-dependent phosphate transport protein 2A Surfactant protein A Transcription factor GATA-6 Transcription termination factor 1	A0A1D5NWQ4 E1BQR6 F1NDD8 F1NQY7 O13076 P43693 Q2LK96 Q90XB2 R4GLV7	ADORA2B ADRA2A ADRA2C GATA6 LL LMCD1 SFTPA1 SLC34A1 SP-A TTF1	Gallus gallus (chicken)
Stimuli-sensing channels	Acid-sensing ion channel 1 Anoctamin Bestrophin homolog Bestrophin homolog Chloride channel protein E3 ubiquitin-protein ligase Osteopetrosis associated transmembrane protein 1 Polyubiquitin-B RAF proto-oncogene serine/threonine-protein kinase Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase Sgk3 Serum/glucocorticoid regulated kinase 2 Sodium channel epithelial 1 subunit gamma Sodium leak channel, non-selective Stomatin like 3 Stomatin Two pore segment channel 1 Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein	A0A1D5P0N6 A0A1D5P546 A0A1D5P6F6 E1BQ97 E1BSL8 E1BTV1 E1BZK5 E1C882 F1NGF2 F1NW62 F1P588 P05625 P0CG62 P79781 Q1XA76 Q5F372 Q5ZJQ4 Q5ZMW4 Q6U1I9	ACCN2 ANO10 ASIC1 BEST3 BEST4 CATSPER4 CLCN4 MIL NALCN OSTM1 RAF1 RCJMB04_16g8 RPS27A SCNN1G SGK SGK1 SGK2 STOM STOML3 UBA80 UBB WWP1	Gallus gallus (chicken)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Insulin-like growth factor I Insulin-like growth factor II	P18254 P33717	IGF1 IGF2	Gallus gallus (chicken)
Signaling by SCF-KIT	GRB2 related adaptor protein 2 GTPase HRas GTPase NRas Growth factor receptor bound protein 10 Growth factor receptor-bound protein 2 Kit ligand Mast/stem cell growth factor receptor Kit Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Protein kinase C Proto-oncogene tyrosine-protein kinase Src SOS Ras/Rac guanine nucleotide exchange factor 1 Signal transducer and activator of transcription 3 Signal transducer and activator of transcription Tyrosine-protein kinase Yes Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type 11 small monomeric GTPase	A0A1D5P405 A0A1D5PEZ2 A0A1D5PT95 A0A3Q2U639 A0A3Q3ACS4 A3R0S3 E1BQF3 E1C2C5 E1C7Z1 F1NZY8 P00523 P08642 P09324 Q08156 Q09108 Q5F352 Q5ZJK3 Q6DV79 Q90687 R4GHL2	FER FYN GRAP2 GRB10 GRB2 HRAS HRAS1 KIT KITLG KRAS NRAS PIK3R1 PIK3R2 PRKCA PTPN11 RCJMB04_17i9 SCF SOS1 SRC STAT3 TEC YES YES1	Gallus gallus (chicken)
Signaling by PDGF	Collagen type IV alpha 1 chain Plasminogen activator Plasminogen Platelet-derived growth factor C Platelet-derived growth factor D Platelet-derived growth factor subunit A Thrombospondin 4 furin	A0A1D5P8P3 A0A3Q2U6E1 E1C209 F1NBP0 F1NWX6 Q90WK2 Q91000 Q9I946	COL4A1 FURIN PDGF-A (L) PDGFA PDGFC PDGFD PLAT PLG SCDGF THBS4	Gallus gallus (chicken)
Signaling by Insulin receptor	Insulin Tyrosine-protein kinase receptor	A0A1D5P6T3 P67970	INS INSR	Gallus gallus (chicken)
Signaling by EGFR	Amphiregulin Angio associated migratory cell protein Betacellulin Epigen Epiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Receptor protein-tyrosine kinase	A0A1D5PKH0 F1NJR9 P00523 Q5EG71 Q5ZLQ3 Q645M5 Q64EU6 Q9W7C5	AAMP AREG BTC EGFR EPGN EREG HBEGF HEGFL SRC	Gallus gallus (chicken)
Signaling by BMP	Activin receptor type-2A Bone morphotic protein 10 Cerberus Dorsalin-1 Gremlin 2, DAN family BMP antagonist Mothers against decapentaplegic homolog 5 Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Transforming growth factor beta receptor 3 receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase	A0A1D5PB14 A0A1D5PNY8 A0A3Q3AYA9 F1NTD3 F1P3H0 F6S3W4 O42124 P34822 Q56I99 Q56IA0 Q90669 Q90998 Q9PWB0	ACVR2A BMP10 BMPR1A BMPR1B BRK-3 CER1 DSL1 GREM2 MADH5 SMAD1 SMAD5 SMAD6 SMAD7 TGFBR3	Gallus gallus (chicken)
Signaling by Activin	Activin receptor type-2A Inhibin beta B chain Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Transforming growth factor beta receptor 3 receptor protein serine/threonine kinase	A0A1D5NUH3 A0A3Q2TUT8 P84023 Q8UWF3 Q90669 Q90998 R4GIS0	ACVR1C ACVR2A INHBB LOC769000 MADH2 MADH3 SMAD3 TGFBR3	Gallus gallus (chicken)
Sialic acid metabolism	Alpha-2,8-sialyltransferase Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Beta-galactoside alpha-2,6-sialyltransferase 2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Major facilitator superfamily (MFS) profile domain-containing protein N-acetylneuraminate synthase ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 exo-alpha-sialidase	A0A1D5PEI3 A0A1D5PIR8 A0A3Q2TVY6 E1BZW3 F6VMN5 P79783 Q11200 Q5ZL94 Q5ZMH8 Q6ZXD0 Q92183 R4GHQ6	NANS NEU2 RCJMB04_7b17 SIAT4A SIAT7A SIAT8C ST3GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC5 ST8SIA4 ST8SIA5 ST8SIA6 Sial-T2	Gallus gallus (chicken)
Scavenging by Class A Receptors	Apolipoprotein A-I Collectin-11 Endoplasmin	A0A1D5PPN9 A0A3Q3A736 P08250	APOA1 COLEC11 HSP90B1	Gallus gallus (chicken)	G70323CJ G82576YO
SHC1 events in EGFR signaling	Amphiregulin Betacellulin Epigen Epiregulin GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Proheparin-binding EGF-like growth factor Receptor protein-tyrosine kinase SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A1D5NYP8 A0A1D5PEZ2 A0A1D5PKH0 A0A1D5PT95 A3R0S3 F1NJR9 P08642 Q5EG71 Q5F352 Q645M5 Q64EU6 Q9W7C5	AREG BTC EGFR EPGN EREG GRB2 HBEGF HEGFL HRAS HRAS1 KRAS NRAS SHC1 SOS1	Gallus gallus (chicken)
SHC-mediated cascade:FGFR3	Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor receptor 3 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A1D5NYP8 A0A1D5PEZ2 A0A1D5PT95 A3R0S3 E1BZW7 P08642 P18460 P19596 P48800 Q197G3 Q4R0X9 Q5F352 Q9I950 R4GIR0	CEK2 FGF-18 FGF1 FGF18 FGF2 FGF23 FGF4 FGF8 FGFR3 Fgf16 GRB2 HRAS HRAS1 KRAS NRAS SHC1 SOS1	Gallus gallus (chicken)
SHC-mediated cascade:FGFR2	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor receptor 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A1D5NYP8 A0A1D5PEZ2 A0A1D5PT95 A0A3Q2TTH8 A3R0S3 E1BZW7 F1P5Y5 P08642 P18461 P19596 P48800 P48801 Q197G3 Q4R0X9 Q5F352 Q5KRA4 Q9I950 R4GIR0	CEK3 FGF-18 FGF-3 FGF1 FGF10 FGF18 FGF2 FGF23 FGF3 FGF4 FGF6 FGF7 FGF8 FGFR2 Fgf16 Fgf7 GRB2 HRAS HRAS1 KRAS NRAS SHC1 SOS1	Gallus gallus (chicken)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor receptor 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A1D5NYP8 A0A1D5PEZ2 A0A1D5PT95 A0A3Q2TTH8 A3R0S3 E1BZW7 F1P5Y5 P08642 P19596 P21804 P48800 P48801 Q4R0X9 Q5F352 R4GIR0	CEK1 FGF-3 FGF1 FGF10 FGF2 FGF23 FGF3 FGF4 FGF6 FGF8 FGFR1 GRB2 HRAS HRAS1 KRAS NRAS SHC1 SOS1	Gallus gallus (chicken)

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