GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **676 - 700** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism
Negative regulators of RIG-I/MDA5 signaling	Antiviral innate immune response receptor RIG-I Autophagy protein 5 E3 ISG15--protein ligase HERC5 E3 ubiquitin-protein ligase Itchy homolog E3 ubiquitin-protein ligase RNF125 E3 ubiquitin-protein ligase RNF135 E3 ubiquitin-protein ligase RNF216 E3 ubiquitin-protein ligase TRIM4 E3 ubiquitin/ISG15 ligase TRIM25 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon regulatory factor 3 Interferon-induced helicase C domain-containing protein 1 Mitochondrial antiviral-signaling protein NLR family member X1 OTU domain-containing protein 5 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Poly(rC)-binding protein 2 Polyubiquitin-B Polyubiquitin-C Protein NLRC5 Serine/threonine-protein kinase TBK1 TNF receptor-associated factor 3 Tax1-binding protein 1 Tumor necrosis factor alpha-induced protein 3 Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-conjugating enzyme E2 K Ubiquitin-like modifier-activating enzyme 7 Ubiquitin-like protein ATG12 Ubiquitin-like protein ISG15 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Ubiquitin/ISG15-conjugating enzyme E2 L6	O14933 O94817 O95786 P05161 P0CG47 P0CG48 P21580 P41226 P51668 P61077 P61086 P62837 P62979 P62987 Q13114 Q13526 Q14164 Q14258 Q14653 Q15366 Q7Z434 Q86UT6 Q86VP1 Q86WI3 Q8IUD6 Q96EQ8 Q96G74 Q96J02 Q9BYX4 Q9C037 Q9H1Y0 Q9NQC7 Q9NWF9 Q9UHD2 Q9UII4	APG12 APG12L APG5L ASP ATG12 ATG5 CAP-1 CEB1 CEBP1 CRAF1 CYLD CYLD1 DDX58 EFP G1P2 HERC5 HIP2 IFIH1 IKBKE IKKE IKKI IPS1 IRF3 ISG15 ITCH KIAA0151 KIAA0849 KIAA1271 LIG MAVS MDA5 NAK NLRC5 NLRX1 NOD27 NOD4 NOD5 NOD9 OTUD5 OTUD7C PCBP2 PIN1 PUBC1 RH116 RIGI RNF125 RNF135 RNF147 RNF216 RNF87 RPS27A SFT T6BP TAX1BP1 TBK1 TNFAIP3 TRAF3 TRAFAMN TRIAD3 TRIM25 TRIM4 UBA52 UBA7 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCE7IP1 UBCEP1 UBCEP2 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBCH8 UBE1L UBE2 UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 UCRP VISA ZIN ZNF147	Homo sapiens (human)
DDX58/IFIH1-mediated induction of interferon-alpha/beta	ATP-dependent RNA helicase DHX58 Antiviral innate immune response receptor RIG-I E3 ISG15--protein ligase HERC5 E3 ubiquitin-protein ligase RNF135 E3 ubiquitin-protein ligase TRIM4 E3 ubiquitin/ISG15 ligase TRIM25 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Interferon regulatory factor 3 Interferon-induced helicase C domain-containing protein 1 Mitochondrial antiviral-signaling protein Mitochondrial import receptor subunit TOM70 NLR family member X1 Nucleoprotein ORF9b protein Protein NLRC5 Serine/threonine-protein kinase TBK1 Triokinase/FMN cyclase Ubiquitin-like modifier-activating enzyme 7 Ubiquitin-like protein ISG15 Ubiquitin/ISG15-conjugating enzyme E2 L6	O14933 O94826 O95786 P05161 P07900 P08238 P0DTC9 P0DTD2 P41226 Q14258 Q14653 Q3LXA3 Q7Z434 Q86UT6 Q86WI3 Q8IUD6 Q96C10 Q9BYX4 Q9C037 Q9UHD2 Q9UII4	9b CEB1 CEBP1 D11LGP2E DAK DDX58 DHX58 EFP G1P2 HERC5 HSP90A HSP90AA1 HSP90AB1 HSP90B HSPC1 HSPC2 HSPC3 HSPCA HSPCB IFIH1 IPS1 IRF3 ISG15 KIAA0719 KIAA1271 LGP2 MAVS MDA5 N NAK NLRC5 NLRX1 NOD27 NOD4 NOD5 NOD9 RH116 RIGI RNF135 RNF147 RNF87 TBK1 TKFC TOM70 TOMM70 TOMM70A TRIM25 TRIM4 UBA7 UBCH8 UBE1L UBE2 UBE2L6 UCRP VISA ZNF147	Homo sapiens (human)
Termination of translesion DNA synthesis	DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA polymerase eta DNA polymerase iota DNA polymerase kappa DNA repair protein REV1 E3 ubiquitin/ISG15 ligase TRIM25 PCNA-associated factor Polyubiquitin-B Polyubiquitin-C Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit Ubiquitin carboxyl-terminal hydrolase 10 Ubiquitin carboxyl-terminal hydrolase 43 Ubiquitin-like modifier-activating enzyme 7 Ubiquitin-like protein ISG15 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Ubiquitin/ISG15-conjugating enzyme E2 L6	O14933 P05161 P0CG47 P0CG48 P12004 P15927 P27694 P28340 P35244 P35249 P35250 P35251 P40937 P40938 P41226 P49005 P56282 P62979 P62987 Q07864 Q14258 Q14694 Q15004 Q15054 Q70EL4 Q9HCU8 Q9NR33 Q9NRF9 Q9UBT6 Q9UBZ9 Q9UNA4 Q9Y253	CHRAC17 DINB1 DPE2 EFP G1P2 ISG15 KIAA0039 KIAA0101 KIAA0190 NS5ATP9 PAF PCLAF PCNA POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 POLH POLI POLK RAD30 RAD30A RAD30B REPA1 REPA2 REPA3 REV1 REV1L RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RNF147 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70 RPS27A TRIM25 UBA52 UBA7 UBA80 UBB UBC UBCEP1 UBCEP2 UBCH8 UBE1L UBE2 UBE2L6 UCRP USP10 USP43 XPV ZNF147	Homo sapiens (human)
Syndecan interactions	Alpha-actinin-1 Fibroblast growth factor 2 Integrin alpha-2 Integrin alpha-6 Integrin alpha-V Integrin beta-1 Integrin beta-3 Integrin beta-4 Integrin beta-5 Peripheral plasma membrane protein CASK Protein kinase C alpha type Syndecan-1 Syndecan-2 Syndecan-3 Syndecan-4 Tenascin Thrombospondin-1 Trafficking protein particle complex subunit 4 Transforming growth factor beta-1 proprotein Vitronectin	O14936 O75056 P01137 P04004 P05106 P05556 P06756 P07996 P09038 P12814 P16144 P17252 P17301 P18084 P18827 P23229 P24821 P31431 P34741 Q9Y296	ACTN1 CASK CD49B FGF2 FGFB FNRB GP3A HSPG1 HXB ITGA2 ITGA6 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 KIAA0468 LIN2 MDF2 MSK12 MSK8 PKCA PRKACA PRKCA SBDN SDC SDC1 SDC2 SDC3 SDC4 TGFB TGFB1 THBS1 TNC TRAPPC4 TSP TSP1 VNRA VTN VTNR	Homo sapiens (human)
Synthesis of PA	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 1-acyl-sn-glycerol-3-phosphate acyltransferase delta 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma Cytosolic phospholipase A2 beta Cytosolic phospholipase A2 delta Cytosolic phospholipase A2 Dihydroxyacetone phosphate acyltransferase Glycerol-3-phosphate acyltransferase 1, mitochondrial Glycerol-3-phosphate acyltransferase 2, mitochondrial Glycerol-3-phosphate acyltransferase 3 Glycerol-3-phosphate acyltransferase 4 Glycerol-3-phosphate dehydrogenase 1-like protein Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic Glycerol-3-phosphate dehydrogenase, mitochondrial Group 10 secretory phospholipase A2 Group IID secretory phospholipase A2 Group IIE secretory phospholipase A2 Group IIF secretory phospholipase A2 Group XIIA secretory phospholipase A2 Intestinal-type alkaline phosphatase Lipase member H Lipase member I Lysocardiolipin acyltransferase 1 Lysophosphatidic acid phosphatase type 6 Lysophosphatidylcholine acyltransferase 1 Lysophospholipid acyltransferase LPCAT4 Mitochondrial cardiolipin hydrolase Mitoguardin 1 Mitoguardin 2 Phospholipase A2 group V Phospholipase A2, membrane associated Phospholipase A2 Phospholipase D1 Phospholipase D2 Phospholipase DDHD1 Phospholipase DDHD2 Secretory phospholipase A2 receptor	O14939 O15120 O15228 O15496 O94830 P04054 P09923 P0C869 P14555 P21695 P39877 P43304 P47712 Q13018 Q13393 Q53EU6 Q643R3 Q6NUI2 Q6UWP7 Q6XZB0 Q7L4E1 Q86UL3 Q86XP0 Q8N2A8 Q8N335 Q8NAN2 Q8NEL9 Q8NF37 Q8WWY8 Q99943 Q9BZM1 Q9BZM2 Q9HCL2 Q9NPH0 Q9NRZ5 Q9NRZ7 Q9NUQ2 Q9NZK7 Q9UNK4	ACP6 ACPL1 AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 AGPAT6 AGPAT7 AGPAT8 AGPAT9 ALCAT1 ALPI AYTL2 AYTL3 C9orf54 CLEC13C CPLA2 DAPAT DDHD1 DDHD2 DHAPAT FAM73A FAM73B G15 GNPAT GPAM GPAT1 GPAT2 GPAT3 GPAT4 GPD1 GPD1L GPD2 KIAA0089 KIAA0725 KIAA1560 KIAA1705 LCLAT1 LIPH LIPI LPAAT3 LPAP LPCAT1 LPCAT4 LPDL LPDLR LPEAT2 LYCAT MAG1 MIGA1 MIGA2 MPAPLA1 PFAAP3 PLA1B PLA2 PLA2A PLA2B PLA2G10 PLA2G12 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4 PLA2G4A PLA2G4B PLA2G4D PLA2G5 PLA2L PLA2R1 PLD1 PLD2 PLD6 PPLA2 RASF-A SAMWD1 SPLASH TSARG7	Homo sapiens (human)
Synthesis of PG	5'-3' exonuclease PLD3 5'-3' exonuclease PLD4 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial Mitochondrial cardiolipin hydrolase Phosphatidate cytidylyltransferase 2 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 Phospholipase D1 Phospholipase D2	O14939 O95674 Q13393 Q32NB8 Q8IV08 Q8N2A8 Q8WUK0 Q96BZ4	C14orf175 CDS2 MOSP PGS1 PLD1 PLD2 PLD3 PLD4 PLD6 PLIP PTPMT1	Homo sapiens (human)
EGFR downregulation	Amphiregulin Cell division control protein 42 homolog E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15-like 1 Epidermal growth factor receptor substrate 15 Epidermal growth factor receptor Epigen Epsin-1 Hepatocyte growth factor-regulated tyrosine kinase substrate Polyubiquitin-B Polyubiquitin-C Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein sprouty homolog 1 Protein sprouty homolog 2 Protransforming growth factor alpha Receptor-type tyrosine-protein phosphatase kappa Rho guanine nucleotide exchange factor 7 SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tyrosine-protein phosphatase non-receptor type 12 Tyrosine-protein phosphatase non-receptor type 3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14944 O14964 O43597 O43609 O75886 P00533 P01133 P01135 P0CG47 P0CG48 P15514 P22681 P26045 P35070 P42566 P60953 P62979 P62987 Q05209 Q14155 Q15262 Q6UW88 Q92783 Q96B97 Q99075 Q99961 Q99962 Q99963 Q9UBC2 Q9Y6I3	AF1P AREG AREGB ARHGEF7 BTC CBL CBL2 CDC42 CIN85 CNSA1 CNSA2 CNSA3 COOL1 DTR DTS EGF EGFR EPGN EPN1 EPS15 EPS15L1 EPS15R ERBB ERBB1 EREG HBEGF HBP HEGFL HER1 HGS HRS KIAA0142 P85SPR PAK3BP PIXB PTPH1 PTPK PTPN12 PTPN3 PTPRK RNF55 RPS27A SDGF SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SPRY1 SPRY2 STAM STAM1 STAM2 TGFA UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Amphiregulin Apoptosis regulator Bcl-2 Cyclin-dependent kinase inhibitor 1B ETS domain-containing protein Elk-1 Epidermal growth factor receptor Epigen Exportin-1 Focal adhesion kinase 1 Forkhead box protein O3 G1/S-specific cyclin-D1 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protein c-Fos Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Serine/threonine-protein kinase Kist Serum response factor	O14944 O14980 O43524 P00533 P01100 P01133 P01135 P10415 P11831 P15514 P19419 P24385 P27361 P28482 P31749 P31751 P35070 P46527 Q05397 Q6UW88 Q8TAS1 Q99075 Q9Y243	AKT1 AKT2 AKT3 AREG AREGB BCL1 BCL2 BTC CCND1 CDKN1B CRM1 DTR DTS EGF EGFR ELK1 EPGN ERBB ERBB1 EREG ERK1 ERK2 FAK FAK1 FKHRL1 FOS FOXO3 FOXO3A G0S7 HBEGF HEGFL HER1 KIP1 KIS KIST MAPK1 MAPK3 PKB PKBG PRAD1 PRKM1 PRKM2 PRKM3 PTK2 RAC SDGF SRF TGFA UHMK1 XPO1 p27	Homo sapiens (human)
SHC1 events in EGFR signaling	Amphiregulin Epidermal growth factor receptor Epigen GTPase HRas GTPase NRas Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha SHC-transforming protein 1 Son of sevenless homolog 1	O14944 P00533 P01111 P01112 P01133 P01135 P15514 P29353 P35070 Q07889 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 HRAS HRAS1 NRAS SDGF SHC SHC1 SHCA SOS1 TGFA	Homo sapiens (human)
GRB2 events in EGFR signaling	Amphiregulin Epidermal growth factor receptor Epigen GTPase HRas GTPase NRas Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha Son of sevenless homolog 1	O14944 P00533 P01111 P01112 P01133 P01135 P15514 P35070 Q07889 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 HRAS HRAS1 NRAS SDGF SOS1 TGFA	Homo sapiens (human)
GAB1 signalosome	Amphiregulin Epidermal growth factor receptor Epigen GRB2-associated-binding protein 1 Paxillin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Protransforming growth factor alpha Tyrosine-protein kinase CSK Tyrosine-protein phosphatase non-receptor type 11	O14944 P00533 P01133 P01135 P12931 P15514 P27986 P35070 P41240 P42336 P49023 Q06124 Q13480 Q6UW88 Q99075 Q9NWQ8	AREG AREGB BTC CBP CSK DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG GAB1 GRB1 HBEGF HEGFL HER1 PAG PAG1 PIK3CA PIK3R1 PTP2C PTPN11 PXN SDGF SHPTP2 SRC SRC1 TGFA	Homo sapiens (human)
EGFR interacts with phospholipase C-gamma	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Amphiregulin Epidermal growth factor receptor Epigen Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha	O14944 P00533 P01133 P01135 P15514 P19174 P35070 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 PLC1 PLCG1 SDGF TGFA	Homo sapiens (human)
Inhibition of Signaling by Overexpressed EGFR	Amphiregulin Epidermal growth factor receptor Epigen Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha	O14944 P00533 P01133 P01135 P15514 P35070 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 SDGF TGFA	Homo sapiens (human)
Transcriptional and post-translational regulation of MITF-M expression and activity	Adenosine 5'-monophosphoramidase HINT1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Arginine--tRNA ligase, cytoplasmic Aspartate--tRNA ligase, cytoplasmic Bifunctional glutamate/proline--tRNA ligase CREB-binding protein Catenin beta-1 Eukaryotic translation elongation factor 1 epsilon-1 Exportin-1 Forkhead box protein D3 Glutamine--tRNA ligase Glycogen synthase kinase-3 beta Homeobox protein aristaless-like 3 Isoleucine--tRNA ligase, cytoplasmic Leucine--tRNA ligase, cytoplasmic Lymphoid enhancer-binding factor 1 Lysine--tRNA ligase Mast/stem cell growth factor receptor Kit Melanocortin receptor 3 Melanocortin receptor 4 Melanocortin receptor 5 Melanocyte-stimulating hormone receptor Methionine--tRNA ligase, cytoplasmic Microphthalmia-associated transcription factor Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 POU domain, class 3, transcription factor 2 Paired box protein Pax-3 Pro-opiomelanocortin Protein Wnt-3a Ribosomal protein S6 kinase alpha-1 Transcription factor E3 Transcription factor EB Transcription factor EC Transcription factor SOX-10 Transcription factor SOX-2	O14948 O14980 O43324 O75030 O95076 P01189 P07814 P10721 P14868 P19484 P19532 P20265 P23760 P27361 P28482 P32245 P33032 P35222 P41252 P41968 P47897 P48431 P49773 P49841 P54136 P56192 P56693 P56704 Q01726 Q12904 Q13155 Q15046 Q15418 Q92793 Q9P2J5 Q9UJU2 Q9UJU5	AIMP1 AIMP2 AIMP3 ALX3 BHLHE32 BHLHE33 BHLHE34 BHLHE35 BRN2 CBP CREBBP CRM1 CTNNB CTNNB1 DARS DARS1 EEF1E1 EMAP2 EPRS EPRS1 ERK1 ERK2 FOXD3 GLNS GSK3B HFH2 HINT HINT1 HUP2 IARS IARS1 JTV1 KARS KARS1 KIAA0070 KIAA1352 KIT LARS LARS1 LEF1 MAPK1 MAPK3 MAPKAPK1A MARS MARS1 MC1R MC3R MC4R MC5R MITF MSHR OCT7 OTF7 P18 PARS PAX3 PKCI1 POMC POU3F2 PRKCNH1 PRKM1 PRKM2 PRKM3 QARS QARS1 QPRS RARS RARS1 RPS6KA1 RSK1 SCFR SCYE1 SOX10 SOX2 TCFEC TFE3 TFEB TFEC TFECL WNT3A XPO1	Homo sapiens (human)
Mitochondrial protein degradation	2-oxoglutarate dehydrogenase complex component E1 3-hydroxyacyl-CoA dehydrogenase type-2 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial 5-aminolevulinate synthase, non-specific, mitochondrial 60 kDa heat shock protein, mitochondrial ADP/ATP translocase 2 ADP/ATP translocase 3 ATP synthase subunit O, mitochondrial ATP synthase subunit a ATP synthase subunit alpha, mitochondrial ATP synthase subunit beta, mitochondrial ATP synthase subunit d, mitochondrial ATP synthase subunit g, mitochondrial ATP synthase subunit gamma, mitochondrial ATP synthase-coupling factor 6, mitochondrial ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial ATP-dependent Clp protease proteolytic subunit, mitochondrial ATP-dependent zinc metalloprotease YME1L1 Acetyl-CoA acetyltransferase, mitochondrial Aconitate hydratase, mitochondrial Acyl-coenzyme A thioesterase 2, mitochondrial Aldehyde dehydrogenase X, mitochondrial Aldehyde dehydrogenase, mitochondrial Arginase-2, mitochondrial Calcium uptake protein 2, mitochondrial Citrate synthase, mitochondrial Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 Cytochrome b-c1 complex subunit 2, mitochondrial Cytochrome b-c1 complex subunit 8 Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial D-beta-hydroxybutyrate dehydrogenase, mitochondrial Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Delta-1-pyrroline-5-carboxylate synthase Dihydrolipoyl dehydrogenase, mitochondrial Dynamin-like GTPase OPA1, mitochondrial Enoyl-CoA delta isomerase 1, mitochondrial Essential MCU regulator, mitochondrial Ferrochelatase, mitochondrial Fumarate hydratase, mitochondrial Glutamate dehydrogenase 1, mitochondrial Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Hydroxymethylglutaryl-CoA synthase, mitochondrial Isobutyryl-CoA dehydrogenase, mitochondrial Isocitrate dehydrogenase [NADP], mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isoleucine--tRNA ligase, mitochondrial Large ribosomal subunit protein bL12m Large ribosomal subunit protein bL32m Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Lon protease homolog, mitochondrial Malate dehydrogenase, mitochondrial Metalloendopeptidase OMA1, mitochondrial Mitochondrial import inner membrane translocase subunit Tim10 Mitochondrial import inner membrane translocase subunit Tim17-A Mitochondrial import inner membrane translocase subunit Tim22 Mitochondrial import inner membrane translocase subunit Tim9 Mitochondrial inner membrane m-AAA protease component AFG3L2 Mitochondrial inner membrane m-AAA protease component paraplegin Mitochondrial-processing peptidase subunit alpha NAD kinase 2, mitochondrial NAD-dependent malic enzyme, mitochondrial NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NADH-ubiquinone oxidoreductase chain 1 NADH-ubiquinone oxidoreductase chain 2 NADH-ubiquinone oxidoreductase chain 5 NADH-ubiquinone oxidoreductase chain 6 PRELI domain-containing protein 1, mitochondrial Probable D-lactate dehydrogenase, mitochondrial Propionyl-CoA carboxylase beta chain, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Serine hydroxymethyltransferase, mitochondrial Serine protease HTRA2, mitochondrial Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Single-stranded DNA-binding protein, mitochondrial Small ribosomal subunit protein uS10m Small ribosomal subunit protein uS2m StAR-related lipid transfer protein 7, mitochondrial Steroidogenic acute regulatory protein, mitochondrial Stress-70 protein, mitochondrial Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial Succinyl-CoA TP53-regulated inhibitor of apoptosis 1 Transcription factor A, mitochondrial Twinkle mtDNA helicase [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial cAMP-dependent protein kinase catalytic subunit alpha	O14949 O43464 O43678 O43715 O60313 O75390 O75489 O75947 O75964 O76031 O95139 P00367 P00395 P00403 P00846 P03886 P03891 P03915 P03923 P05091 P05141 P05166 P06576 P07954 P08559 P09622 P10606 P10809 P11177 P11182 P12236 P13073 P13196 P17612 P18859 P20674 P22695 P22830 P23368 P24752 P25705 P28331 P30837 P34897 P36542 P36776 P38646 P40926 P42126 P45954 P48047 P48735 P49675 P49753 P49821 P50213 P52815 P54868 P54886 P55809 P56181 P62072 P78540 P82664 Q00059 Q02218 Q02338 Q04837 Q10713 Q13011 Q15118 Q16740 Q16836 Q4G0N4 Q86WU2 Q8IYU8 Q96E52 Q96I99 Q96RR1 Q96TA2 Q99595 Q99714 Q99798 Q9BYC8 Q9H4I9 Q9NQZ5 Q9NSE4 Q9NWU1 Q9P0J0 Q9UKU7 Q9UQ90 Q9Y255 Q9Y399 Q9Y4W6 Q9Y584 Q9Y5J7 Q9Y6H1	15E1.1 AAC2 AAC3 ACAD8 ACADSB ACAT ACAT1 ACO2 ACOT2 AFG3L2 ALAS1 ALAS3 ALASH ALDH18A1 ALDH1B1 ALDH2 ALDH5 ALDHX ALDM ANT2 ANT3 ARC42 ARG2 ATP5A ATP5A1 ATP5AL2 ATP5B ATP5C ATP5C1 ATP5CL1 ATP5F1A ATP5F1B ATP5F1C ATP5H ATP5J ATP5L ATP5MG ATP5O ATP5PD ATP5PF ATP5PO ATP6 ATPASE6 ATPM ATPMB ATPO ATPSB BCATE2 BCKDHE2 BDH BDH1 C10orf2 C22orf32 C5orf33 C7orf17 CAR CHCHD2 CLPP CLPX CMAR COI COII COX2 COX4 COX4I1 COX5A COX5B COXI COXII CS DBT DCI DLD ECH1 ECI1 EFHA1 EMRE ERAB FECH FH FTSH1 GCSL GLUD GLUD1 GRIM19 GRP75 GSAS GTT1 HAD HAD1 HADH HADH2 HADHSC HMGCS2 HSD17B10 HSP60 HSPA9 HSPA9B HSPD1 HTRA2 IARS2 IBD IDH2 IDH3A INPP5E KIAA0123 KIAA0567 LAD LDHD LONP1 MAT MDH2 ME2 MICU2 MIMT17 MNADK MPPA MPRP1 MRPL12 MRPL32 MRPL7 MRPP2 MRPS10 MRPS2 MT-ATP6 MT-CO1 MT-CO2 MT-ND1 MT-ND2 MT-ND5 MT-ND6 MTATP6 MTCO1 MTCO2 MTND1 MTND2 MTND5 MTND6 NADH1 NADH2 NADH5 NADH6 NADK2 NADKD1 ND1 ND2 ND5 ND6 NDUFA13 NDUFA2 NDUFB6 NDUFS1 NDUFS3 NDUFV1 NDUFV3 OGDH OMA1 OMI OPA1 OXCT OXCT1 OXSM P5CS PCCB PDHA1 PDHB PDHK1 PDK1 PEO1 PGN PHE1A PHE1B PHE3 PKACA PMPCA PRELI PRELID1 PRKACA PRSS15 PRSS25 PTE2 PTE2A PYCS RPML12 SCHAD SCOT SDR5C1 SDR9C1 SHMT2 SLC25A5 SLC25A6 SMDT1 SPG7 SSBP SSBP1 STAR STARD1 STARD7 SUCLG2 TCF6 TCF6L2 TEX4 TFAM TIM10 TIM17 TIM17A TIM22 TIM9 TIM9A TIMM10 TIMM17 TIMM17A TIMM22 TIMM9 TIMM9A TRIAP1 TWNK UQCRC2 UQCRQ UQOR1 XH98G2 YME1L YME1L1 mt-HSP70	Homo sapiens (human)
RHO GTPases activate PKNs	14-3-3 protein beta/alpha 14-3-3 protein epsilon 14-3-3 protein eta 14-3-3 protein gamma 14-3-3 protein sigma 14-3-3 protein theta 14-3-3 protein zeta/delta 3-phosphoinositide-dependent protein kinase 1 M-phase inducer phosphatase 3 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 12B Protein phosphatase 1 regulatory subunit 14A Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase N3 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Transforming protein RhoA	O14950 O14974 O15530 O60237 P08134 P24844 P27348 P30307 P31946 P31947 P35579 P35580 P35749 P60660 P61586 P61981 P62140 P62258 P62745 P63000 P63104 Q04917 Q13153 Q16512 Q16513 Q6P5Z2 Q7Z406 Q96A00	ARH12 ARH6 ARH9 ARHA ARHB ARHC CDC25C CPI17 HME1 KIAA0866 KIAA2034 MBS MLC2 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYPT1 MYPT2 MYRL2 PAK1 PDK1 PDPK1 PKN PKN1 PKN2 PKN3 PKNBETA PPP1CB PPP1INL PPP1R12A PPP1R12B PPP1R14A PRK1 PRK2 PRKCL1 PRKCL2 RAC1 RHO12 RHOA RHOB RHOC SFN TC25 YWHA1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	Homo sapiens (human)
RHO GTPases Activate ROCKs	Cofilin-1 LIM domain kinase 1 LIM domain kinase 2 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 12B Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Serine/threonine-protein kinase PAK 1 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Transforming protein RhoA	O14950 O14974 O60237 O75116 P08134 P23528 P24844 P35579 P35580 P35749 P53667 P53671 P60660 P61586 P62140 P62745 Q13153 Q13464 Q7Z406	ARH12 ARH6 ARH9 ARHA ARHB ARHC CFL CFL1 KIAA0619 KIAA0866 KIAA2034 LIMK LIMK1 LIMK2 MBS MLC2 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYPT1 MYPT2 MYRL2 PAK1 PPP1CB PPP1R12A PPP1R12B RHO12 RHOA RHOB RHOC ROCK1 ROCK2	Homo sapiens (human)
RHO GTPases activate PAKs	Calmodulin-1 Cell division control protein 42 homolog Filamin-A LIM domain kinase 1 Merlin Myosin light chain kinase, smooth muscle Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Protein phosphatase 1 regulatory subunit 12A Protein phosphatase 1 regulatory subunit 12B Ras-related C3 botulinum toxin substrate 1 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein phosphatase PP1-beta catalytic subunit Src substrate cortactin	O14950 O14974 O60237 O75914 P0DP23 P21333 P24844 P35240 P35579 P35580 P35749 P53667 P60660 P60953 P62140 P63000 Q13153 Q13177 Q14247 Q15746 Q7Z406	CALM CALM1 CAM CAM1 CDC42 CTTN EMS1 FLN FLN1 FLNA KIAA0866 KIAA2034 LIMK LIMK1 MBS MLC2 MLCK MLCK1 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYLK MYLK1 MYPT1 MYPT2 MYRL2 NF2 OPHN3 PAK1 PAK2 PAK3 PPP1CB PPP1R12A PPP1R12B RAC1 SCH TC25	Homo sapiens (human)
Sema4D induced cell migration and growth-cone collapse	LIM domain kinase 1 LIM domain kinase 2 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Plexin-B1 Receptor tyrosine-protein kinase erbB-2 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein Rho6 Rho-related GTP-binding protein RhoB Rho-related GTP-binding protein RhoC Semaphorin-4D Transforming protein RhoA	O14950 O15085 O43157 O75116 P04626 P08134 P24844 P35579 P35580 P35749 P53667 P53671 P60660 P61586 P62745 Q13464 Q7Z406 Q92730 Q92854 Q9NZN5	ARH12 ARH6 ARH9 ARHA ARHB ARHC ARHGEF11 ARHGEF12 C9orf164 CD100 ERBB2 HER2 KIAA0380 KIAA0382 KIAA0407 KIAA0619 KIAA0866 KIAA2034 LARG LIMK LIMK1 LIMK2 MLC2 MLN19 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYRL2 NEU NGL PLXN5 PLXNB1 RHO12 RHO6 RHOA RHOB RHOC RND1 ROCK1 ROCK2 SEMA4D SEMAJ SEP	Homo sapiens (human)
Smooth Muscle Contraction	Actin, aortic smooth muscle Actin, gamma-enteric smooth muscle Aldehyde dehydrogenase, mitochondrial Annexin A1 Annexin A2 Annexin A6 Caldesmon Calmodulin-1 Caveolin-3 Dysferlin Guanylate cyclase soluble subunit alpha-1 Guanylate cyclase soluble subunit alpha-2 Guanylate cyclase soluble subunit beta-1 Guanylate cyclase soluble subunit beta-2 Integrin alpha-1 Integrin beta-5 Leiomodin-1 Myosin light chain 5 Myosin light chain 6B Myosin light chain kinase, smooth muscle Myosin light polypeptide 6 Myosin regulatory light chain 10 Myosin regulatory light chain 11 Myosin regulatory light chain 12A Myosin regulatory light chain 12B Myosin regulatory light chain 2, atrial isoform Myosin regulatory light polypeptide 9 Myosin-11 Paxillin Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Sorbin and SH3 domain-containing protein 1 Talin-1 Tripartite motif-containing protein 72 Tropomyosin alpha-1 chain Tropomyosin alpha-3 chain Tropomyosin alpha-4 chain Tropomyosin beta chain Vinculin Vinexin Voltage-dependent T-type calcium channel subunit alpha-1G Voltage-dependent T-type calcium channel subunit alpha-1H Voltage-dependent T-type calcium channel subunit alpha-1I cGMP-specific 3',5'-cyclic phosphodiesterase	O14950 O43497 O60504 O75343 O75923 O76074 O95180 P04083 P05091 P06753 P07355 P07951 P08133 P09493 P0DP23 P14649 P18084 P18206 P19105 P24844 P29536 P33402 P35749 P49023 P56199 P56539 P60660 P62736 P63267 P67936 Q01449 Q02045 Q02108 Q02153 Q05682 Q13153 Q13177 Q15746 Q6ZMU5 Q96A32 Q9BUA6 Q9BX66 Q9P0X4 Q9Y490	ACTA2 ACTA3 ACTG2 ACTL3 ACTSA ACTSG ACTVS ALDH2 ALDM ANX1 ANX2 ANX2L4 ANX6 ANXA1 ANXA2 ANXA6 C15orf13 CACNA1G CACNA1H CACNA1I CAD CAL1H CALD1 CALM CALM1 CAM CAM1 CAV3 CDM DYSF FER1L1 GUC1A2 GUC1A3 GUC1B3 GUCSA2 GUCSA3 GUCSB3 GUCY1A1 GUCY1A2 GUCY1A3 GUCY1B1 GUCY1B2 GUCY1B3 HSRLC ITGA1 ITGB5 KIAA0866 KIAA0894 KIAA1027 KIAA1120 KIAA1123 KIAA1296 LMOD1 LPC1 LPC2D MG53 MLC1SA MLC2 MLCB MLCK MLCK1 MRLC1 MRLC2 MRLC3 MYH11 MYL10 MYL11 MYL12A MYL12B MYL2A MYL5 MYL6 MYL6B MYL7 MYL9 MYLC2A MYLC2B MYLC2PL MYLK MYLK1 MYLPF MYRL2 PAK1 PAK2 PDE5 PDE5A PLRLC PXN RLC SCAM1 SH3D5 SORBS1 SORBS3 TLN TLN1 TMSA TMSB TPM1 TPM2 TPM3 TPM4 TRIM72 VCL	Homo sapiens (human)
EPHA-mediated growth cone collapse	Ephexin-1 Myosin light polypeptide 6 Myosin regulatory light chain 12B Myosin regulatory light polypeptide 9 Myosin-10 Myosin-11 Myosin-14 Myosin-9 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Transforming protein RhoA Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes	O14950 O75116 P06241 P07947 P07948 P24844 P35579 P35580 P35749 P60660 P61586 Q13464 Q7Z406 Q8N5V2	ARH12 ARHA FYN JTK8 KIAA0619 KIAA0866 KIAA2034 LYN MLC2 MRLC1 MRLC2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLC2B MYRL2 NGEF RHO12 RHOA ROCK1 ROCK2 YES YES1	Homo sapiens (human)
Prevention of phagosomal-lysosomal fusion	Coronin-1A Dihydrolipoyl dehydrogenase ESAT-6-like protein EsxG ESAT-6-like protein EsxH Hepatocyte growth factor-regulated tyrosine kinase substrate Lipoarabinomannan carrier protein LprG Low molecular weight protein-tyrosine phosphatase A Nucleoside diphosphate kinase Phosphatidylinositol-3-phosphatase Polyubiquitin-B Polyubiquitin-C Probable triacylglyceride transporter Rv1410c Protein translocase subunit SecA 2 Ras-related protein Rab-5A Ras-related protein Rab-7a Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Vacuolar protein sorting-associated protein 33B	O14964 O53361 O53692 P0CG47 P0CG48 P20339 P31146 P51149 P62979 P62987 P9WGP3 P9WHH9 P9WIA1 P9WJH7 P9WJY3 P9WK45 P9WNK3 Q9H267	CORO1 CORO1A HGS HRS RAB5 RAB5A RAB7 RAB7A RPS27A Rv1410c UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 VPS33B cfp7 esxG esxH lpd lpdC lpp-27 lprG mptpA ndk ndkA ptpA sapM secA2	Homo sapiens (human)
Inhibition of membrane repair	ESAT-6-like protein EsxG ESAT-6-like protein EsxH Hepatocyte growth factor-regulated tyrosine kinase substrate	O14964 O53692 P9WNK3	HGS HRS cfp7 esxG esxH	Homo sapiens (human)
RHOBTB3 ATPase cycle	Cullin-3 G1/S-specific cyclin-E1 Hepatocyte growth factor-regulated tyrosine kinase substrate Leucine-rich repeat-containing protein 41 Perilipin-3 Ras-related protein Rab-9A Ras-related protein Rab-9B Rho-related BTB domain-containing protein 3 von Hippel-Lindau disease tumor suppressor	O14964 O60664 O94955 P24864 P40337 P51151 Q13618 Q15345 Q9NP90	CCNE CCNE1 CUL3 HGS HRS KIAA0617 KIAA0878 LRRC41 M6PRBP1 MUF1 PLIN3 RAB9 RAB9A RAB9B RAB9L RHOBTB3 TIP47 VHL	Homo sapiens (human)
InlB-mediated entry of Listeria monocytogenes into host cell	E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Internalin B Internalin B Polyubiquitin-B Polyubiquitin-C SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14964 O75886 P08581 P0CG47 P0CG48 P0DQD2 P0DQD3 P22681 P42566 P62979 P62987 Q92783 Q96B97 Q99961 Q99962 Q99963	AF1P CBL CBL2 CIN85 CNSA1 CNSA2 CNSA3 EPS15 HBP HGS HRS MET RNF55 RPS27A SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM1 STAM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 inlB	Homo sapiens (human)

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