GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **701 - 725** of **2090** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism
Negative regulation of MET activity	E3 ubiquitin-protein ligase CBL Endophilin-A1 Endophilin-A2 Endophilin-A3 Epidermal growth factor receptor substrate 15 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Hepatocyte growth factor Leucine-rich repeats and immunoglobulin-like domains protein 1 Polyubiquitin-B Polyubiquitin-C Receptor-type tyrosine-protein phosphatase eta SH3 domain-containing kinase-binding protein 1 Signal transducing adapter molecule 1 Signal transducing adapter molecule 2 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 2 Ubiquitin carboxyl-terminal hydrolase 8 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14964 O75886 P08581 P0CG47 P0CG48 P14210 P17706 P18031 P22681 P40818 P42566 P62979 P62987 Q12913 Q92783 Q96B97 Q96JA1 Q99961 Q99962 Q99963	AF1P CBL CBL2 CIN85 CNSA1 CNSA2 CNSA3 DEP1 EPS15 HBP HGF HGS HPTA HRS KIAA0055 LIG1 LRIG1 MET PTP1B PTPN1 PTPN2 PTPRJ PTPT RNF55 RPS27A SH3D2A SH3D2B SH3D2C SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM1 STAM2 UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UBPY USP8	Homo sapiens (human)
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	14-3-3 protein sigma Apoptosis regulator BAX Aurora kinase A Cellular tumor antigen p53 Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Growth arrest and DNA damage-inducible protein GADD45 alpha Histone acetyltransferase p300 Histone-arginine methyltransferase CARM1 M-phase inducer phosphatase 3 Proliferating cell nuclear antigen Protein arginine N-methyltransferase 1 Retinoblastoma-like protein 1 Retinoblastoma-like protein 2 Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F4 Zinc finger protein 385A	O14965 P04637 P06493 P12004 P14635 P24522 P28749 P30307 P31947 Q07812 Q08999 Q09472 Q14186 Q14188 Q16254 Q86X55 Q96PM9 Q99873	AIK AIRK1 ARK1 AURA AURKA AYK1 BAX BCL2L4 BTAK CARM1 CCNB CCNB1 CDC2 CDC25C CDC28A CDK1 CDKN1 DDIT1 DP1 DP2 E2F4 EP300 GADD45 GADD45A HME1 HMT2 HRMT1L2 HZF IAK1 IR1B4 P300 P34CDC2 P53 PCNA PRMT1 PRMT4 RB2 RBL1 RBL2 RZF SFN STK15 STK6 TFDP1 TFDP2 TP53 ZNF385 ZNF385A	Homo sapiens (human)
Interaction between PHLDA1 and AURKA	Aurora kinase A Pleckstrin homology-like domain family A member 1	O14965 Q8WV24	AIK AIRK1 ARK1 AURA AURKA AYK1 BTAK IAK1 PHLDA1 PHRIP STK15 STK6 TDAG51	Homo sapiens (human)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	24-hydroxycholesterol 7-alpha-hydroxylase 3 beta-hydroxysteroid dehydrogenase type 7 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Aldo-keto reductase family 1 member C1 Aldo-keto reductase family 1 member C2 Aldo-keto reductase family 1 member C3 Aldo-keto reductase family 1 member C4 Aldo-keto reductase family 1 member D1 Alpha-methylacyl-CoA racemase Cholesterol 24-hydroxylase Long-chain fatty acid transport protein 2 Long-chain fatty acid transport protein 5 Prostacyclin synthase Sterol 26-hydroxylase, mitochondrial	O14975 P17516 P42330 P51857 P52895 Q02318 Q04828 Q16647 Q9H2F3 Q9NYL5 Q9UHK6 Q9UNU6 Q9Y2P5 Q9Y6A2	ACSB ACSVL1 ACSVL6 AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AMACR CHDR CYP12 CYP27 CYP27A1 CYP39A1 CYP46 CYP46A1 CYP8 CYP8A1 CYP8B1 DDH DDH1 DDH2 FACVL1 FACVL3 FATP2 FATP5 HSD17B5 HSD3B7 KIAA0119 PGFS PTGIS SLC27A2 SLC27A5 SRD5B1 VLACS	Homo sapiens (human)
Downregulation of TGF-beta receptor signaling	BMP and activin membrane-bound inhibitor homolog E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF1 E3 ubiquitin-protein ligase SMURF2 Exportin-1 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 7 Myotubularin-related protein 4 Polyubiquitin-B Polyubiquitin-C Protein TMEPAI Protein phosphatase 1 regulatory subunit 15A Serine-threonine kinase receptor-associated protein Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta-1 proprotein Ubiquitin carboxyl-terminal hydrolase 15 Ubiquitin carboxyl-terminal hydrolase isozyme L5 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O14980 O15105 O75807 P01137 P0CG47 P0CG48 P36873 P36897 P37173 P62136 P62140 P62979 P62987 P84022 Q13145 Q15796 Q969W9 Q96PU5 Q9HAU4 Q9HCE7 Q9NYA4 Q9UNE7 Q9Y3F4 Q9Y4E8 Q9Y5K5	ALK5 BAMBI CHIP CRM1 GADD34 KIAA0439 KIAA0529 KIAA0647 KIAA1625 MADH2 MADH3 MADH7 MADH8 MADR2 MAWD MTMR4 NEDD4L NEDL3 NMA PMEPA1 PPP1A PPP1CA PPP1CB PPP1CC PPP1R15A RPS27A SKR4 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STAG1 STRAP STUB1 TGFB TGFB1 TGFBR1 TGFBR2 TMEPAI UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 UCH37 UCHL5 UNRIP USP15 XPO1 ZFYVE11	Homo sapiens (human)
HuR (ELAVL1) binds and stabilizes mRNA	Acidic leucine-rich nuclear phosphoprotein 32 family member A ELAV-like protein 1 Exportin-1 Nuclear pore complex protein Nup214 Protein SET Protein kinase C alpha type Protein kinase C delta type Tumor necrosis factor ligand superfamily member 13	O14980 O75888 P17252 P35658 P39687 Q01105 Q05655 Q15717	ANP32A APRIL C15orf1 CAIN CAN CRM1 ELAVL1 HUR KIAA0023 LANP MAPM NUP214 PHAP1 PKCA PKCD PRKACA PRKCA PRKCD SET TALL2 TNFSF13 XPO1 ZTNF2	Homo sapiens (human)
Cyclin A/B1/B2 associated events during G2/M transition	CDK-activating kinase assembly factor MAT1 Cyclin-A1 Cyclin-A2 Cyclin-H Cyclin-dependent kinase 1 Cyclin-dependent kinase 2 Cyclin-dependent kinase 7 Exportin-1 Forkhead box protein M1 G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B2 Leucine carboxyl methyltransferase 1 M-phase inducer phosphatase 1 M-phase inducer phosphatase 2 M-phase inducer phosphatase 3 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Protein phosphatase methylesterase 1 Serine/threonine-protein kinase PLK1 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta Wee1-like protein kinase	O14980 O95067 P06493 P14635 P20248 P24941 P30153 P30154 P30291 P30304 P30305 P30307 P50613 P51946 P51948 P53350 P62714 P63151 P67775 P78396 Q08050 Q99640 Q9UIC8 Q9Y570 Q9Y5P8	CAK CAK1 CAP35 CCN1 CCNA CCNA1 CCNA2 CCNB CCNB1 CCNB2 CCNH CDC2 CDC25A CDC25B CDC25C CDC25HU2 CDC28A CDK1 CDK2 CDK7 CDKN1 CDKN2 CDKN7 CRM1 FKHL16 FOXM1 HFH11 LCMT LCMT1 MAT1 MNAT1 MO15 MPP2 MYT1 P34CDC2 PKMYT1 PLK PLK1 PME1 PPME1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R3L RNF66 STK1 WEE1 WIN XPO1	Homo sapiens (human)
Maturation of hRSV A proteins	Casein kinase II subunit alpha' Casein kinase II subunit alpha Casein kinase II subunit beta Exportin-1 Furin Fusion glycoprotein F0 Importin subunit beta-1 Matrix protein Non-structural protein 1 Non-structural protein 2 Nucleoprotein Phosphoprotein Protein M2-1 RNA-directed RNA polymerase L Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Signal peptidase complex catalytic subunit SEC11A Signal peptidase complex catalytic subunit SEC11C Signal peptidase complex subunit 1 Signal peptidase complex subunit 2 Signal peptidase complex subunit 3	O14980 P03418 P03420 P03421 P04543 P04545 P09958 P0DOE7 P0DOE9 P19784 P28887 P36873 P61009 P62136 P62140 P67812 P67870 P68400 P70168 Q15005 Q9BY50 Q9Y6A9	1B 1C CK2A1 CK2A2 CK2N CRM1 CSNK2A1 CSNK2A2 CSNK2B F FUR FURIN G5A Impnb KIAA0102 Kpnb1 L M M2-1 N NS1 NS2 P PACE PCSK3 PPP1A PPP1CA PPP1CB PPP1CC SEC11A SEC11C SEC11L1 SEC11L3 SPC12 SPC18 SPC21 SPC22 SPC25 SPCS1 SPCS2 SPCS3 SPCS4A SPCS4C XPO1	Homo sapiens (human)
Reduction of cytosolic Ca++ levels	Calmodulin-1 Plasma membrane calcium-transporting ATPase 1 Plasma membrane calcium-transporting ATPase 2 Plasma membrane calcium-transporting ATPase 3 Plasma membrane calcium-transporting ATPase 4 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Sodium/calcium exchanger 1 Sodium/calcium exchanger 2 Sodium/calcium exchanger 3 Sorcin	O14983 P0DP23 P16615 P20020 P23634 P30626 P32418 P57103 Q01814 Q16720 Q93084 Q9UPR5	ATP2A1 ATP2A2 ATP2A3 ATP2B ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM CALM1 CAM CAM1 CNC KIAA1087 MXRA1 NCX1 NCX2 NCX3 PMCA1 PMCA2 SLC8A1 SLC8A2 SLC8A3 SRI	Homo sapiens (human)
Interaction between L1 and Ankyrins	Ankyrin-1 Ankyrin-2 Ankyrin-3 Neural cell adhesion molecule L1 Neurofascin Neuronal cell adhesion molecule Potassium voltage-gated channel subfamily KQT member 2 Potassium voltage-gated channel subfamily KQT member 3 Sodium channel protein type 1 subunit alpha Sodium channel protein type 10 subunit alpha Sodium channel protein type 11 subunit alpha Sodium channel protein type 2 subunit alpha Sodium channel protein type 3 subunit alpha Sodium channel protein type 4 subunit alpha Sodium channel protein type 5 subunit alpha Sodium channel protein type 7 subunit alpha Sodium channel protein type 8 subunit alpha Sodium channel protein type 9 subunit alpha Sodium channel regulatory subunit beta-3 Sodium channel subunit beta-1 Sodium channel subunit beta-2 Sodium channel subunit beta-4 Spectrin alpha chain, erythrocytic 1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, erythrocytic Spectrin beta chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 2 Spectrin beta chain, non-erythrocytic 4 Spectrin beta chain, non-erythrocytic 5	O15020 O43525 O43526 O60939 O94856 P02549 P11277 P16157 P32004 P35498 P35499 Q01082 Q01118 Q01484 Q07699 Q12955 Q13813 Q14524 Q15858 Q8IWT1 Q92823 Q99250 Q9H254 Q9NRC6 Q9NY46 Q9NY72 Q9UI33 Q9UQD0 Q9Y5Y9	ANK ANK1 ANK2 ANK3 ANKB BSPECV CAML1 HBA HUBSPECV HUSPECV KCNQ2 KCNQ3 KIAA0302 KIAA0343 KIAA0756 KIAA1158 KIAA1356 KIAA1642 L1CAM MED MIC5 NAC1 NAC2 NAC3 NEAS NENA NFASC NRCAM SCA5 SCN1 SCN10A SCN11A SCN12A SCN1A SCN1B SCN2A SCN2A1 SCN2A2 SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN6A SCN7A SCN8A SCN9A SNS2 SPTA SPTA1 SPTA2 SPTAN1 SPTB SPTB1 SPTB2 SPTBN1 SPTBN2 SPTBN3 SPTBN4 SPTBN5	Homo sapiens (human)
NCAM signaling for neurite out-growth	Focal adhesion kinase 1 GTPase HRas GTPase NRas Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Neural cell adhesion molecule 1 Receptor-type tyrosine-protein phosphatase alpha Ribosomal protein S6 kinase alpha-5 Son of sevenless homolog 1 Spectrin alpha chain, erythrocytic 1 Spectrin alpha chain, non-erythrocytic 1 Spectrin beta chain, erythrocytic Spectrin beta chain, non-erythrocytic 1 Spectrin beta chain, non-erythrocytic 2 Spectrin beta chain, non-erythrocytic 4 Spectrin beta chain, non-erythrocytic 5 Tyrosine-protein kinase Fyn	O15020 O75582 P01111 P01112 P02549 P06241 P11277 P13591 P18433 P27361 P28482 Q01082 Q05397 Q07889 Q13813 Q9H254 Q9NRC6	BSPECV ERK1 ERK2 FAK FAK1 FYN HRAS HRAS1 HUBSPECV HUSPECV KIAA0302 KIAA1642 MAPK1 MAPK3 MSK1 NCAM NCAM1 NEAS NRAS PRKM1 PRKM2 PRKM3 PTK2 PTPA PTPRA PTPRL2 RPS6KA5 SCA5 SOS1 SPTA SPTA1 SPTA2 SPTAN1 SPTB SPTB1 SPTB2 SPTBN1 SPTBN2 SPTBN3 SPTBN4 SPTBN5	Homo sapiens (human)
Other semaphorin interactions	B-cell differentiation antigen CD72 Integrin alpha-1 Integrin beta-1 Plexin-A1 Plexin-A2 Plexin-A4 Plexin-B3 Plexin-C1 Plexin-D1 Receptor-type tyrosine-protein phosphatase C Semaphorin-3E Semaphorin-4A Semaphorin-4D Semaphorin-5A Semaphorin-6A Semaphorin-6D Semaphorin-7A TYRO protein tyrosine kinase-binding protein Triggering receptor expressed on myeloid cells 2	O15041 O43914 O60486 O75051 O75326 P05556 P08575 P21854 P56199 Q13591 Q8NFY4 Q92854 Q9H2E6 Q9H3S1 Q9HCM2 Q9NZC2 Q9UIW2 Q9ULL4 Q9Y4D7	C9orf164 CD100 CD108 CD45 CD72 DAP12 FNRB ITGA1 ITGB1 KARAP KIAA0331 KIAA0463 KIAA0620 KIAA1206 KIAA1368 KIAA1479 KIAA1550 MDF2 MSK12 NOV OCT PLXN1 PLXN2 PLXN6 PLXNA1 PLXNA2 PLXNA4 PLXNA4A PLXNA4B PLXNB3 PLXNC1 PLXND1 PTPRC SEMA3E SEMA4A SEMA4D SEMA5A SEMA6A SEMA6D SEMA7A SEMAB SEMAF SEMAH SEMAJ SEMAL SEMAQ SEMB TREM2 TYROBP VESPR	Homo sapiens (human)
Chromatin modifications during the maternal to zygotic transition (MZT)	Developmental pluripotency-associated protein 3 E3 ubiquitin-protein ligase UHRF1 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-arginine methyltransferase METTL23 Lysine-specific demethylase 5A Lysine-specific demethylase 5B Lysine-specific demethylase 6A Lysine-specific demethylase 6B Methylcytosine dioxygenase TET3 Protein STPG4 Single-stranded DNA cytosine deaminase Uracil-DNA glycosylase	O15054 O15550 O43151 O60814 P04908 P06899 P0C5Y9 P13051 P16104 P20671 P23527 P29375 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q16777 Q16778 Q6FI13 Q6W0C5 Q71DI3 Q71UI9 Q86XA0 Q8N257 Q8N801 Q93077 Q93079 Q96A08 Q96T88 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9GZX7 Q9UGL1	AICDA AID C17orf95 C2orf61 DGU DPPA3 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 ICBP90 JARID1A JARID1B JMJD3 KDM5A KDM5B KDM6A KDM6B KIAA0346 KIAA0401 METTL23 NP95 PLU1 RBBP2 RBBP2H1 RBP2 RNF106 STELLAR STPG4 TET3 TSH2B UHRF1 UNG UNG1 UNG15 UTX	Homo sapiens (human)
Purine ribonucleoside monophosphate biosynthesis	Adenylosuccinate lyase Adenylosuccinate synthetase isozyme 1 Adenylosuccinate synthetase isozyme 2 Amidophosphoribosyltransferase Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase Bifunctional purine biosynthesis protein ATIC GMP synthase [glutamine-hydrolyzing] Inosine-5'-monophosphate dehydrogenase 1 Inosine-5'-monophosphate dehydrogenase 2 Phosphoribosylformylglycinamidine synthase Trifunctional purine biosynthetic protein adenosine-3	O15067 P12268 P20839 P22102 P22234 P30520 P30566 P31939 P49915 Q06203 Q8N142	ADE2 ADSL ADSS ADSS1 ADSS2 ADSSL1 AIRC AMPS ATIC GART GMPS GPAT IMPD1 IMPD2 IMPDH1 IMPDH2 KIAA0361 PAICS PAIS PFAS PGFT PPAT PRGS PURH	Homo sapiens (human)
tRNA modification in the mitochondrion	3-hydroxyacyl-CoA dehydrogenase type-2 Mitochondrial ribonuclease P catalytic subunit Mitochondrial tRNA-specific 2-thiouridylase 1 Protein MTO1 homolog, mitochondrial tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial tRNA dimethylallyltransferase tRNA methyltransferase 10 homolog C tRNA modification GTPase GTPBP3, mitochondrial	O15091 O75648 Q7L0Y3 Q969Y2 Q99714 Q9BVS5 Q9H3H1 Q9Y2Z2	ERAB GTPBP3 HADH2 HSD17B10 IPT KIAA0391 MOD5 MRPP1 MRPP2 MRPP3 MTGP1 MTO1 MTU1 PRORP RG9MTD1 SCHAD SDR5C1 TRIT1 TRMT1 TRMT10C TRMT61B TRMU XH98G2	Homo sapiens (human)
tRNA processing in the mitochondrion	3-hydroxyacyl-CoA dehydrogenase type-2 CCA tRNA nucleotidyltransferase 1, mitochondrial Mitochondrial ribonuclease P catalytic subunit Zinc phosphodiesterase ELAC protein 2 tRNA methyltransferase 10 homolog C	O15091 Q7L0Y3 Q96Q11 Q99714 Q9BQ52	ELAC2 ERAB HADH2 HPC2 HSD17B10 KIAA0391 MRPP1 MRPP2 MRPP3 PRORP RG9MTD1 SCHAD SDR5C1 TRMT10C TRNT1 XH98G2	Homo sapiens (human)
rRNA processing in the mitochondrion	3-hydroxyacyl-CoA dehydrogenase type-2 Mitochondrial ribonuclease P catalytic subunit Zinc phosphodiesterase ELAC protein 2 tRNA methyltransferase 10 homolog C	O15091 Q7L0Y3 Q99714 Q9BQ52	ELAC2 ERAB HADH2 HPC2 HSD17B10 KIAA0391 MRPP1 MRPP2 MRPP3 PRORP RG9MTD1 SCHAD SDR5C1 TRMT10C XH98G2	Homo sapiens (human)
Downregulation of SMAD2/3:SMAD4 transcriptional activity	E3 ubiquitin-protein ligase Arkadia E3 ubiquitin-protein ligase NEDD4-like E3 ubiquitin-protein ligase SMURF2 E3 ubiquitin-protein ligase TRIM33 Histone deacetylase 1 Homeobox protein TGIF1 Homeobox protein TGIF2 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4 Mothers against decapentaplegic homolog 7 Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Poly [ADP-ribose] polymerase 1 Polyubiquitin-B Polyubiquitin-C Protein ATP1B4 Protein phosphatase 1A SNW domain-containing protein 1 Ski oncogene Ski-like protein Ubiquitin carboxyl-terminal hydrolase 9X Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein WW domain-containing transcription regulator protein 1	O15105 O75376 P09874 P0CG47 P0CG48 P12755 P12757 P27361 P28482 P35813 P51668 P61077 P62979 P62987 P84022 Q13485 Q13547 Q13573 Q15583 Q15796 Q6ZNA4 Q93008 Q96PU5 Q9GZN2 Q9GZV5 Q9HAU4 Q9UN42 Q9UPN9 Q9Y618	ADPRT ATP1B4 CTG26 DFFRX DPC4 ERK1 ERK2 FAM HDAC1 KIAA0439 KIAA1047 KIAA1113 MADH2 MADH3 MADH4 MADH7 MADH8 MADR2 MAPK1 MAPK3 NCOR1 NCOR2 NEDD4L NEDL3 PARP1 PPM1A PPOL PPPM1A PRKM1 PRKM2 PRKM3 RFG7 RNF111 RPD3L1 RPS27A SFT SKI SKIIP SKIL SKIP SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SNO SNW1 TAZ TGIF TGIF1 TGIF2 TIF1G TRIM33 UBA52 UBA80 UBB UBC UBC5A UBC5C UBCEP1 UBCEP2 UBCH5 UBCH5A UBCH5C UBE2D1 UBE2D3 USP9 USP9X WWTR1	Homo sapiens (human)
AKT phosphorylates targets in the cytosol	Bcl2-associated agonist of cell death Caspase-9 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase makorin-1 Glycogen synthase kinase-3 alpha Glycogen synthase kinase-3 beta Inhibitor of nuclear factor kappa-B kinase subunit alpha Proline-rich AKT1 substrate 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tuberin	O15111 P31749 P31751 P38936 P46527 P49815 P49840 P49841 P55211 Q00987 Q92934 Q96B36 Q9UHC7 Q9Y243	AKT1 AKT1S1 AKT2 AKT3 BAD BBC6 BCL2L8 CAP20 CASP9 CDKN1 CDKN1A CDKN1B CHUK CIP1 GSK3A GSK3B IKKA KIP1 MCH6 MDA6 MDM2 MKRN1 PIC1 PKB PKBG PRAS40 RAC RNF61 SDI1 TCF16 TSC2 TSC4 WAF1 p27	Homo sapiens (human)
mRNA decay by 5' to 3' exoribonuclease	5'-3' exoribonuclease 1 Enhancer of mRNA-decapping protein 3 Enhancer of mRNA-decapping protein 4 Probable ATP-dependent RNA helicase DDX6 Protein PAT1 homolog 1 U6 snRNA-associated Sm-like protein LSm1 U6 snRNA-associated Sm-like protein LSm2 U6 snRNA-associated Sm-like protein LSm3 U6 snRNA-associated Sm-like protein LSm4 U6 snRNA-associated Sm-like protein LSm5 U6 snRNA-associated Sm-like protein LSm6 U6 snRNA-associated Sm-like protein LSm7 m7GpppN-mRNA hydrolase mRNA-decapping enzyme 1A mRNA-decapping enzyme 1B	O15116 P26196 P62310 P62312 Q6P2E9 Q86TB9 Q8IU60 Q8IZD4 Q8IZH2 Q96F86 Q9NPI6 Q9UK45 Q9Y333 Q9Y4Y9 Q9Y4Z0	C6orf28 CASM DCP1A DCP1B DCP2 DDX6 EDC3 EDC4 G7B HEDLS HLR2 LSM1 LSM16 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 NUDT20 PATL1 RCK SEP1 SMIF XRN1 YJDC YJEFN2	Homo sapiens (human)
LDL clearance	AP-2 complex subunit alpha-1 AP-2 complex subunit alpha-2 AP-2 complex subunit beta AP-2 complex subunit mu AP-2 complex subunit sigma Apolipoprotein B-100 Carboxylesterase 3 Clathrin heavy chain 1 Clathrin light chain A Lipolysis-stimulated lipoprotein receptor Low density lipoprotein receptor adapter protein 1 Low-density lipoprotein receptor Lysosomal acid lipase/cholesteryl ester hydrolase NPC intracellular cholesterol transporter 1 NPC intracellular cholesterol transporter 2 Neutral cholesterol ester hydrolase 1 Proprotein convertase subtilisin/kexin type 9 Sterol O-acyltransferase 1 Sterol O-acyltransferase 2	O15118 O75908 O94973 O95782 P01130 P04114 P09496 P35610 P38571 P53680 P61916 P63010 Q00610 Q5SW96 Q6PIU2 Q6UWW8 Q86X29 Q8NBP7 Q96CW1	AADACL1 ACACT ACACT1 ACACT2 ACAT ACAT1 ACAT2 ADTAA ADTAB ADTB2 AP17 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOB ARH CES3 CLAPA1 CLAPA2 CLAPB1 CLAPM1 CLAPS2 CLH17 CLTA CLTC CLTCL2 HE1 HIP9 HYPJ ILDR3 KIAA0034 KIAA0109 KIAA0899 KIAA1363 LDLR LDLRAP1 LIPA LISCH LSR NARC1 NCEH1 NPC1 NPC2 PCSK9 SOAT SOAT1 SOAT2 STAT	Homo sapiens (human)
Orexin and neuropeptides FF and QRFP bind to their respective receptors	Hypocretin neuropeptide precursor Neuropeptide FF receptor 1 Neuropeptide FF receptor 2 Orexigenic neuropeptide QRFP Orexin receptor type 2 Orexin/Hypocretin receptor type 1 Pro-FMRFamide-related neuropeptide FF Pyroglutamylated RF-amide peptide receptor	O15130 O43612 O43613 O43614 P83859 Q96P65 Q9GZQ6 Q9Y5X5	GPR103 GPR147 GPR74 HCRT HCRTR1 HCRTR2 NPFF NPFF1 NPFF2 NPFFR1 NPFFR2 NPGPR OX PPORX PPOX QRFP QRFPR	Homo sapiens (human)
Stabilization of p53	Cellular tumor antigen p53 E3 ubiquitin-protein ligase Mdm2 PHD finger protein 20 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Tumor suppressor ARF Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O15151 O96017 P04637 P0CG47 P0CG48 P62979 P62987 Q00987 Q13315 Q8N726 Q9BVI0	ATM C20orf104 CDKN2 CDKN2A CDS1 CHEK2 CHK2 GLEA2 HCA58 MDM2 MDM4 MDMX MLM NZF P53 PHF20 RAD53 RPS27A TP53 TZP UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
B-WICH complex positively regulates rRNA expression	Actin, cytoplasmic 1 DNA excision repair protein ERCC-6 DNA-directed RNA polymerase I subunit RPA12 DNA-directed RNA polymerase I subunit RPA1 DNA-directed RNA polymerase I subunit RPA2 DNA-directed RNA polymerase I subunit RPA34 DNA-directed RNA polymerase I subunit RPA43 DNA-directed RNA polymerase I subunit RPA49 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Glycogen synthase kinase-3 beta Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone acetyltransferase KAT2A Histone acetyltransferase KAT2B Histone acetyltransferase p300 Myb-binding protein 1A Nucleolar RNA helicase 2 Protein DEK Protein POLR1D, isoform 2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Splicing factor 3B subunit 1 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein Tyrosine-protein kinase BAZ1B	O15160 O15446 O60264 O60814 O75533 O95602 P04908 P06899 P0C5Y9 P0DPB5 P16104 P19388 P20226 P20671 P23527 P33778 P35659 P49841 P52434 P53803 P57053 P58876 P60709 P61218 P62805 P62807 P62875 P68431 P84243 Q03468 Q09472 Q15572 Q15573 Q16777 Q16778 Q3B726 Q53T94 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q92830 Q92831 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BQG0 Q9BTM1 Q9GZS1 Q9H5J8 Q9H9Y6 Q9NR30 Q9P1U0 Q9UIG0	ACTB ASE1 BAZ1B CAST CD3EAP CSB DDX21 DEK EP300 ERCC6 GCN5 GCN5L2 GSK3B GTF2D1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 JOSD3 KAT2A KAT2B MYBBP1A P160 P300 PAF49 PAF53 PCAF POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L POLRF PRAF1 RPA12 SAP155 SF3B1 SMARCA5 SNF2H TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TSH2B TWISTNB WBSC10 WBSCR10 WBSCR9 WCRF135 WSTF ZNRD1	Homo sapiens (human)
RNA Polymerase I Promoter Escape	CDK-activating kinase assembly factor MAT1 Chromobox protein homolog 3 Cyclin-H Cyclin-dependent kinase 7 DNA-directed RNA polymerase I subunit RPA12 DNA-directed RNA polymerase I subunit RPA1 DNA-directed RNA polymerase I subunit RPA2 DNA-directed RNA polymerase I subunit RPA34 DNA-directed RNA polymerase I subunit RPA43 DNA-directed RNA polymerase I subunit RPA49 DNA-directed RNA polymerases I and III subunit RPAC1 DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC2 DNA-directed RNA polymerases I, II, and III subunit RPABC3 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH helicase/translocase subunit XPB General transcription factor IIH subunit 1 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 General transcription factor IIH subunit 5 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Nucleolar transcription factor 1 Protein POLR1D, isoform 2 RNA polymerase I-specific transcription initiation factor RRN3 TATA box-binding protein-associated factor RNA polymerase I subunit A TATA box-binding protein-associated factor RNA polymerase I subunit B TATA box-binding protein-associated factor RNA polymerase I subunit C TATA box-binding protein-associated factor RNA polymerase I subunit D TATA-box-binding protein	O15160 O15446 O60814 O95602 P04908 P06899 P0C5Y9 P0DPB5 P16104 P17480 P18074 P19388 P19447 P20226 P20671 P23527 P32780 P33778 P50613 P51946 P51948 P52434 P53803 P57053 P58876 P61218 P62805 P62807 P62875 P68431 P84243 Q13185 Q13888 Q13889 Q15572 Q15573 Q16777 Q16778 Q3B726 Q53T94 Q6FI13 Q6ZYL4 Q71DI3 Q71UI9 Q8N257 Q92759 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9GZS1 Q9H5J8 Q9H9Y6 Q9NYV6 Q9P1U0	ASE1 BTF2 BTF2P44 C6orf175 CAK CAK1 CAP35 CAST CBX3 CCNH CD3EAP CDK7 CDKN7 ERCC2 ERCC3 GTF2D1 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 JOSD3 MAT1 MNAT1 MO15 PAF49 PAF53 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L POLRF PRAF1 RNF66 RPA12 RRN3 STK1 TAF1A TAF1B TAF1C TAF1D TBP TF2D TFIID TIFIA TSH2B TTDA TWISTNB UBF UBF1 UBTF XPB XPBC XPD XPDC ZNRD1	Homo sapiens (human)

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