GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **726 - 750** of **2090** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism
RAF-independent MAPK1/3 activation	Astrocytic phosphoprotein PEA-15 Dual specificity protein phosphatase 10 Dual specificity protein phosphatase 16 Dual specificity protein phosphatase 1 Dual specificity protein phosphatase 2 Dual specificity protein phosphatase 4 Dual specificity protein phosphatase 5 Dual specificity protein phosphatase 6 Dual specificity protein phosphatase 7 Dual specificity protein phosphatase 8 Dual specificity protein phosphatase 9 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3	P27361 P28482 P28562 Q05923 Q13115 Q13202 Q15121 Q16690 Q16828 Q16829 Q99956 Q9BY84 Q9Y6W6	C11orf81 CL100 DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 ERK1 ERK2 KIAA1700 MAPK1 MAPK3 MKP1 MKP2 MKP3 MKP4 MKP5 MKP7 PAC1 PEA15 PRKM1 PRKM2 PRKM3 PTPN10 PYST1 PYST2 VH1 VH2 VH3 VH5	Homo sapiens (human)
RAF activation	14-3-3 protein beta/alpha BRCA1-associated protein Calcium/calmodulin-dependent protein kinase type II subunit alpha Calcium/calmodulin-dependent protein kinase type II subunit beta Calcium/calmodulin-dependent protein kinase type II subunit delta Calcium/calmodulin-dependent protein kinase type II subunit gamma Calmodulin-1 Dual specificity mitogen-activated protein kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 2 GTPase HRas GTPase NRas Kinase suppressor of Ras 1 Leucine-rich repeat protein SHOC-2 MAP/microtubule affinity-regulating kinase 3 Mitogen-activated protein kinase kinase kinase 11 Prohibitin 1 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras-related protein M-Ras Serine/threonine-protein kinase A-Raf Serine/threonine-protein kinase B-raf Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Serine/threonine-protein phosphatase PP1-beta catalytic subunit Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Tyrosine-protein kinase JAK2	O14807 O60674 P01111 P01112 P04049 P0DP23 P10398 P12931 P15056 P27448 P30153 P30154 P31946 P35232 P36507 P36873 P62140 P62714 P67775 Q02750 Q13362 Q13554 Q13555 Q13557 Q14738 Q15172 Q15173 Q16537 Q16584 Q7Z569 Q8IVT5 Q9UQ13 Q9UQM7	ARAF ARAF1 BRAF BRAF1 BRAP CALM CALM1 CAM CAM1 CAM2 CAMK CAMK-II CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMKA CAMKB CAMKD CAMKG CTAK1 EMK2 HRAS HRAS1 JAK2 KIAA0044 KIAA0862 KIAA0968 KSR KSR1 MAP2K1 MAP2K2 MAP3K11 MARK3 MEK1 MEK2 MKK2 MLK3 MRAS NRAS PHB PHB1 PKS PKS2 PPP1CB PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKMK1 PRKMK2 PTK1 RAF RAF1 RAFB1 RNF52 RRAS3 SHOC2 SPRK SRC SRC1 YWHAB	Homo sapiens (human)
RAC3 GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Abl interactor 1 Abl interactor 2 Actin remodeling regulator NHS Actin-binding protein WASF1 Actin-binding protein WASF2 Active breakpoint cluster region-related protein Amphoterin-induced protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 BAR/IMD domain-containing adapter protein 2-like 1 BAR/IMD domain-containing adapter protein 2 Breakpoint cluster region protein Caveolin-1 Cdc42 effector protein 1 Cell division control protein 42 homolog Cell surface glycoprotein MUC18 Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein 1 DEP domain-containing protein 1B Dedicator of cytokinesis protein 10 Delta(14)-sterol reductase LBR Desmoglein-2 Emerin Ephrin type-A receptor 2 Erbin Extended synaptotagmin-1 Fermitin family homolog 2 Granule associated Rac and RHOG effector protein 1 Guanine nucleotide exchange factor VAV2 Inner nuclear membrane protein Man1 Inositol polyphosphate 5-phosphatase OCRL Integrin beta-1 Interleukin-32 Lamina-associated polypeptide 2, isoforms beta/gamma MAGUK p55 subfamily member 7 Membrane-associated progesterone receptor component 2 NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase activator 1 NADPH oxidase organizer 1 Nck-associated protein 1-like Nck-associated protein 1 Neutral amino acid transporter B(0) Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Protein BRICK1 Protein ERGIC-53 Protein diaphanous homolog 3 Protein jagged-1 Proto-oncogene DBL Rac GTPase-activating protein 1 Ragulator complex protein LAMTOR1 Rap guanine nucleotide exchange factor 1 Ras-related C3 botulinum toxin substrate 3 Ras-related protein Rab-7a Rho GDP-dissociation inhibitor 2 Rho GTPase-activating protein 15 Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 42 Rho GTPase-activating protein 5 Rho GTPase-activating protein 6 Rho GTPase-activating protein SYDE1 Rho guanine nucleotide exchange factor TIAM1 SLIT and NTRK-like protein 3 SLIT and NTRK-like protein 5 SLIT-ROBO Rho GTPase-activating protein 2 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase TAO3 Serine/threonine-protein kinase VRK2 Starch-binding domain-containing protein 1 Switch-associated protein 70 Synaptobrevin homolog YKT6 Synaptosomal-associated protein 23 Transferrin receptor protein 1 Triple functional domain protein Tyrosine-protein kinase ABL2 Vang-like protein 1 Vesicle-associated membrane protein 3	A6NI28 A7KAX9 O00161 O00459 O15063 O15173 O15498 O43182 O60890 O75044 O75962 O94933 O94991 O95210 O96013 P02786 P04839 P05556 P10911 P11274 P13498 P14598 P19878 P24001 P27986 P29317 P42167 P42684 P43121 P49257 P50402 P51149 P52566 P52735 P55160 P60763 P60953 P78504 Q00587 Q01968 Q03135 Q07960 Q12979 Q13009 Q13017 Q13153 Q13177 Q13905 Q14126 Q14161 Q14739 Q15080 Q15758 Q15836 Q53QZ3 Q5T2T1 Q5T5U3 Q68EM7 Q6IAA8 Q6T4R5 Q6ZW31 Q7L576 Q86SJ2 Q86UR1 Q86Y07 Q8IZP0 Q8NFA2 Q8TAA9 Q8TCU6 Q8WUW1 Q8WUY9 Q8WWN8 Q8WZ64 Q92558 Q96AC1 Q96BY6 Q96RT1 Q9BSJ8 Q9C0H5 Q9H0H5 Q9H2K8 Q9HBY0 Q9NRY4 Q9NSV4 Q9NYB9 Q9UH65 Q9UHR4 Q9UNA1 Q9UQB8 Q9Y2A7 Q9Y2U8 Q9Y2X7 Q9Y5S8 Q9Y6W5	ABI1 ABI2 ABL2 ABLL ABR ALI1 AMIGO2 ARAP2 ARAP3 ARG ARGBPIA ARHGAP1 ARHGAP10 ARHGAP15 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP34 ARHGAP35 ARHGAP39 ARHGAP42 ARHGAP5 ARHGAP6 ARHGDIB ASCT2 BAIAP2 BAIAP2L1 BCR BCR1 BORG5 BRK1 C11orf59 C3orf10 CAV CAV1 CDC42 CDC42EP1 CDC42GAP CDHF5 CENTD1 CENTD3 CEP1 CYBA CYBB CYFIP1 D22S11 DBL DEPDC1B DG6 DIAP3 DIAPH3 DOCK10 DPK DSG2 ECK EDMD EMD EPHA2 ERBB2IP ERBIN ERGIC53 ESYT1 F5F8D FAM62A FERMT2 FNBP2 FNRB GARRE1 GDIA2 GDID4 GIT1 GIT2 GRAF GRAF3 GRB1 GRF1 GRF2 GRIT GRLF1 HEM1 HEM2 IL32 IRTKS ITGB1 JAG1 JAGL1 JIK KDS KIAA0068 KIAA0148 KIAA0269 KIAA0355 KIAA0456 KIAA0580 KIAA0587 KIAA0621 KIAA0640 KIAA0694 KIAA0712 KIAA0747 KIAA0848 KIAA0918 KIAA1142 KIAA1225 KIAA1415 KIAA1424 KIAA1478 KIAA1688 KIAA1722 KIND2 LAMTOR1 LAP2 LBR LEMD3 LMAN1 LRRC11 M7V1 MAN1 MAP3K18 MBC2 MCAM MCF2 MDF2 MGCRACGAP MIG2 MOX1 MOX2 MPP7 MSE55 MSK12 MUC18 NAP1 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NHS NK4 NOH1 NOX1 NOX2 NOX3 NOXA1 NOXA2 NOXO1 NOXO2 OCRL OCRL1 OPHN1 OPHN1L P190A P41NOX P51NOX P67PHOX PAK1 PAK2 PAK4 PDRO PGRMC2 PIK3R1 PIK3R2 PLEKHC1 PMBP PREX1 RAB7 RAB7A RAC3 RACGAP1 RAP1GN1 RAPGEF1 RDR RDRC RHOGAP1 RHOGAP5 RHOGAP6 RICH1 RICS SCAR1 SH3PXD1A SH3PXD4 SH3PXD5 SLC1A5 SLITRK3 SLITRK5 SNAP23 SRGAP2 SRGAP2A SSH3BP1 STA STB2 STBD1 SWAP70 SYB3 SYDE1 TAIF TAOK3 TFRC TIAM1 TMEM133 TMPO TRIO VAMP3 VANGL1 VAV2 VRK2 WASF1 WASF2 WAVE1 WAVE2 XTP8 YKT6 ZIZ3 p190ARHOGAP	Homo sapiens (human)
RAC2 GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Abl interactor 1 Abl interactor 2 Actin remodeling regulator NHS Actin-binding protein WASF2 Active breakpoint cluster region-related protein Ankyrin repeat and LEM domain-containing protein 2 Armadillo repeat-containing X-linked protein 3 BAR/IMD domain-containing adapter protein 2-like 1 Breakpoint cluster region protein Caveolin-1 Cdc42 effector protein 1 Cdc42 effector protein 4 Cell division control protein 42 homolog Cell surface glycoprotein MUC18 Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein 1 DEP domain-containing protein 1B Dedicator of cytokinesis protein 10 Dedicator of cytokinesis protein 1 Dedicator of cytokinesis protein 2 Dedicator of cytokinesis protein 3 Dedicator of cytokinesis protein 4 Delta(14)-sterol reductase LBR Desmoglein-2 Differentially expressed in FDCP 6 homolog Emerin Ephrin type-A receptor 2 Erbin Extended synaptotagmin-1 Granule associated Rac and RHOG effector protein 1 Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Inner nuclear membrane protein Man1 Integrin beta-1 Lamina-associated polypeptide 2, isoforms beta/gamma MAGUK p55 subfamily member 7 Membrane-associated progesterone receptor component 2 Metaxin-1 Nck-associated protein 1-like Nck-associated protein 1 Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phospholipase D2 Protein BRICK1 Protein ERGIC-53 Protein diaphanous homolog 3 Proto-oncogene DBL Proto-oncogene vav Rac GTPase-activating protein 1 Ragulator complex protein LAMTOR1 Ras GTPase-activating-like protein IQGAP1 Ras-related C3 botulinum toxin substrate 2 Ras-related protein Rab-7a Rho GDP-dissociation inhibitor 1 Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 42 Rho GTPase-activating protein SYDE1 Rho guanine nucleotide exchange factor TIAM1 SLIT and NTRK-like protein 5 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase TAO3 Serine/threonine-protein kinase VRK2 Sorting and assembly machinery component 50 homolog Starch-binding domain-containing protein 1 Switch-associated protein 70 Transferrin receptor protein 1 Triple functional domain protein Vang-like protein 1 Vesicle-associated membrane protein 3 Vesicle-associated membrane protein-associated protein B/C	A6NI28 A7KAX9 O00459 O14939 O15063 O15173 O60890 O75962 O94991 O95210 O95292 O96013 P02786 P04839 P05556 P10911 P11274 P13498 P14598 P15153 P15498 P19878 P27986 P29317 P42167 P42336 P43121 P46940 P49257 P50402 P51149 P52565 P52735 P55160 P60953 Q00587 Q03135 Q07960 Q12979 Q13009 Q13153 Q13177 Q13505 Q14126 Q14161 Q14185 Q14739 Q15080 Q15836 Q5T2T1 Q5T5U3 Q68EM7 Q6IAA8 Q6T4R5 Q6ZW31 Q7L576 Q86XL3 Q86Y07 Q8IZD9 Q8IZP0 Q8N1I0 Q8TAA9 Q8TCU6 Q8WUW1 Q8WUY9 Q92569 Q92608 Q96BY6 Q96RT1 Q9BSJ8 Q9C0H5 Q9H0H5 Q9H2K8 Q9H3Q1 Q9H4E7 Q9NRY4 Q9NSV4 Q9NYB9 Q9UH62 Q9UH65 Q9UHR4 Q9UKW4 Q9UNA1 Q9Y2A7 Q9Y2U8 Q9Y2X7 Q9Y512 Q9Y6W5	ABI1 ABI2 ABR ALEX3 ANKLE2 ARGBPIA ARHGAP1 ARHGAP10 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP42 ARHGDIA ARMCX3 BAIAP2L1 BCR BCR1 BORG4 BORG5 BRK1 C11orf59 C3orf10 CAV CAV1 CDC42 CDC42EP1 CDC42EP4 CDC42GAP CDHF5 CEP1 CEP4 CYBA CYBB CYFIP1 D22S11 DBL DEF6 DEPDC1B DG6 DIAP3 DIAPH3 DOCK1 DOCK10 DOCK2 DOCK3 DOCK4 DPK DSG2 ECK EDMD EMD EPHA2 ERBB2IP ERBIN ERGIC53 ESYT1 F5F8D FAM62A FNRB GARRE1 GDIA1 GIT1 GIT2 GRAF GRAF3 GRB1 GRF1 GRIT GRLF1 HEM1 HEM2 IBP IQGAP1 IRTKS ITGB1 JIK KDS KIAA0051 KIAA0068 KIAA0148 KIAA0209 KIAA0299 KIAA0355 KIAA0587 KIAA0621 KIAA0640 KIAA0692 KIAA0694 KIAA0712 KIAA0716 KIAA0747 KIAA0918 KIAA1142 KIAA1225 KIAA1415 KIAA1424 KIAA1478 KIAA1688 KIAA1722 LAMTOR1 LAP2 LBR LEM4 LEMD3 LMAN1 LRRC11 MAN1 MAP3K18 MBC2 MCAM MCF2 MDF2 MGCRACGAP MOCA MPP7 MSE55 MSK12 MTX MTX1 MTXN MUC18 NAP1 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NHS NOX2 NOXA2 NOXO2 OPHN1 OPHN1L P190A P67PHOX PAK1 PAK2 PAK4 PDRO PGRMC2 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLD2 PMBP PREX1 RAB7 RAB7A RAC2 RACGAP1 RHOGAP1 RICH1 RICS SAM50 SAMM50 SH3PXD1A SH3PXD4 SLITRK5 SSH3BP1 STA STB2 STBD1 SWAP70 SYB3 SYDE1 TAOK3 TFRC TIAM1 TMEM133 TMPO TRIO VAMP3 VANGL1 VAPB VAV VAV1 VAV2 VAV3 VRK2 WASF2 WAVE2 XTP8 ZIZ3 p190ARHOGAP	Homo sapiens (human)
RAC1 GTPase cycle	ARF GTPase-activating protein GIT1 ARF GTPase-activating protein GIT2 Abl interactor 1 Abl interactor 2 Actin nucleation-promoting factor WAS Actin nucleation-promoting factor WASL Actin remodeling regulator NHS Actin-binding protein WASF1 Actin-binding protein WASF2 Actin-binding protein WASF3 Active breakpoint cluster region-related protein Alsin Amphoterin-induced protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 BAR/IMD domain-containing adapter protein 2-like 1 BAR/IMD domain-containing adapter protein 2 Beta-chimaerin Breakpoint cluster region protein Caveolin-1 Cdc42 effector protein 1 Cdc42 effector protein 4 Cell division control protein 42 homolog Cell surface glycoprotein MUC18 Citron Rho-interacting kinase Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein 1 Cytoplasmic FMR1-interacting protein 2 DEP domain-containing protein 1B Dedicator of cytokinesis protein 10 Dedicator of cytokinesis protein 11 Dedicator of cytokinesis protein 1 Dedicator of cytokinesis protein 2 Dedicator of cytokinesis protein 3 Dedicator of cytokinesis protein 4 Dedicator of cytokinesis protein 5 Dedicator of cytokinesis protein 6 Dedicator of cytokinesis protein 7 Dedicator of cytokinesis protein 8 Dedicator of cytokinesis protein 9 Delta(14)-sterol reductase LBR Differentially expressed in FDCP 6 homolog Emerin Ephexin-1 Ephrin type-A receptor 2 Erbin Extended synaptotagmin-1 FERM, ARHGEF and pleckstrin domain-containing protein 1 FERM, ARHGEF and pleckstrin domain-containing protein 2 FYVE, RhoGEF and PH domain-containing protein 5 Fermitin family homolog 2 Formin-like protein 1 GEM-interacting protein Granule associated Rac and RHOG effector protein 1 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Guanine nucleotide exchange factor VAV3 Guanine nucleotide-binding protein subunit alpha-13 Inner nuclear membrane protein Man1 Integrin beta-1 Kalirin Kinectin Lamina-associated polypeptide 2, isoforms beta/gamma MAGUK p55 subfamily member 7 N-chimaerin NADPH oxidase 1 NADPH oxidase 3 NADPH oxidase activator 1 NADPH oxidase organizer 1 Nck-associated protein 1-like Nck-associated protein 1 Neutral amino acid transporter B(0) Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Neutrophil cytosol factor 4 Nischarin Oligophrenin-1 Partitioning defective 6 homolog alpha Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phospholipase D1 Phospholipase D2 Pleckstrin homology domain-containing family G member 1 Pleckstrin homology domain-containing family G member 2 Pleckstrin homology domain-containing family G member 3 Pleckstrin homology domain-containing family G member 6 Protein BRICK1 Protein ECT2 Protein FAM13A Protein FAM13B Protein diaphanous homolog 3 Protein jagged-1 Proto-oncogene DBL Proto-oncogene vav Puratrophin-1 Rac GTPase-activating protein 1 Ragulator complex protein LAMTOR1 RalA-binding protein 1 Ras GTPase-activating-like protein IQGAP1 Ras GTPase-activating-like protein IQGAP2 Ras GTPase-activating-like protein IQGAP3 Ras-related C3 botulinum toxin substrate 1 Ras-related protein Rab-7a Ras-specific guanine nucleotide-releasing factor 2 Rho GDP-dissociation inhibitor 1 Rho GDP-dissociation inhibitor 2 Rho GTPase-activating protein 10 Rho GTPase-activating protein 12 Rho GTPase-activating protein 15 Rho GTPase-activating protein 17 Rho GTPase-activating protein 1 Rho GTPase-activating protein 20 Rho GTPase-activating protein 21 Rho GTPase-activating protein 22 Rho GTPase-activating protein 23 Rho GTPase-activating protein 24 Rho GTPase-activating protein 25 Rho GTPase-activating protein 26 Rho GTPase-activating protein 27 Rho GTPase-activating protein 29 Rho GTPase-activating protein 30 Rho GTPase-activating protein 31 Rho GTPase-activating protein 32 Rho GTPase-activating protein 33 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 42 Rho GTPase-activating protein 44 Rho GTPase-activating protein 45 Rho GTPase-activating protein 4 Rho GTPase-activating protein 5 Rho GTPase-activating protein 7 Rho GTPase-activating protein 9 Rho GTPase-activating protein SYDE2 Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 15 Rho guanine nucleotide exchange factor 18 Rho guanine nucleotide exchange factor 19 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 39 Rho guanine nucleotide exchange factor 4 Rho guanine nucleotide exchange factor 5 Rho guanine nucleotide exchange factor 6 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor TIAM1 Rho guanine nucleotide exchange factor TIAM2 SH3 domain-binding protein 1 SLIT-ROBO Rho GTPase-activating protein 1 SLIT-ROBO Rho GTPase-activating protein 2 SLIT-ROBO Rho GTPase-activating protein 3 Serine/threonine-protein kinase MRCK alpha Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase PAK 1 Serine/threonine-protein kinase PAK 2 Serine/threonine-protein kinase PAK 3 Serine/threonine-protein kinase PAK 4 Serine/threonine-protein kinase PAK 5 Serine/threonine-protein kinase PAK 6 Serine/threonine-protein kinase TAO3 Serine/threonine-protein kinase VRK2 Son of sevenless homolog 1 Son of sevenless homolog 2 Spermatogenesis-associated protein 13 Switch-associated protein 70 Synaptobrevin homolog YKT6 Synaptosomal-associated protein 23 T-cell activation Rho GTPase-activating protein Transferrin receptor protein 1 Triple functional domain protein Tyrosine-protein kinase ABL2 Unconventional myosin-IXb Vang-like protein 1 Vesicle-associated membrane protein 3 WAS/WASL-interacting protein family member 1 WAS/WASL-interacting protein family member 2 WAS/WASL-interacting protein family member 3	A1A4S6 A1L390 A6NGB9 A6NI28 A7KAX9 O00161 O00401 O00459 O14559 O14578 O14827 O14939 O15013 O15063 O15068 O15085 O15498 O43295 O43516 O60229 O60890 O75044 O75914 O75962 O94887 O94988 O94989 O95466 O96013 P02786 P04839 P05556 P10911 P11274 P13498 P14598 P15498 P15882 P19878 P27986 P29317 P42167 P42331 P42336 P42684 P42768 P43121 P46940 P50402 P51149 P52565 P52566 P52735 P52757 P55160 P60953 P63000 P78504 P98171 Q00587 Q03135 Q07889 Q07890 Q07960 Q12774 Q12979 Q13009 Q13017 Q13153 Q13177 Q13393 Q13459 Q13576 Q14155 Q14161 Q14185 Q14344 Q14739 Q15052 Q15080 Q15311 Q15758 Q15836 Q16512 Q16513 Q17R89 Q2M1Z3 Q3KR16 Q52LW3 Q53QZ3 Q58EX7 Q5JSL3 Q5T2T1 Q5T5U3 Q5VT25 Q5VT97 Q68EM7 Q6IAA8 Q6T4R5 Q6ZNL6 Q6ZSZ5 Q6ZUM4 Q70Z35 Q7L576 Q7Z5H3 Q7Z6B7 Q7Z6I6 Q86SJ2 Q86UP2 Q86UR1 Q86VI3 Q86VW2 Q86Y07 Q8IVF5 Q8IW93 Q8IWW6 Q8IZD9 Q8IZP0 Q8N103 Q8N1I0 Q8N264 Q8N4T4 Q8N5V2 Q8NF50 Q8NFA2 Q8TAA9 Q8TCU6 Q8TF74 Q8WUW1 Q8WUY9 Q8WWN8 Q8WZ64 Q92558 Q92569 Q92608 Q92619 Q96AC1 Q96BY6 Q96F07 Q96HP0 Q96N67 Q96N96 Q96P48 Q96Q42 Q96QB1 Q96RT1 Q9BRR9 Q9BSJ8 Q9BZ29 Q9C0H5 Q9H0H5 Q9H2K8 Q9H3Q1 Q9H4E7 Q9H7D0 Q9H7P9 Q9H8V3 Q9HBY0 Q9NPB6 Q9NQU5 Q9NR80 Q9NRY4 Q9NSV4 Q9NYB9 Q9NYF5 Q9P107 Q9P227 Q9P286 Q9P2F6 Q9UH65 Q9UHR4 Q9UKW4 Q9ULL1 Q9UNA1 Q9UPY6 Q9UQB8 Q9Y2A7 Q9Y2I1 Q9Y2U8 Q9Y2X7 Q9Y3L3 Q9Y4F1 Q9Y5S8 Q9Y6W5	ABI1 ABI2 ABL2 ABLL ABR ALI1 ALS2 ALS2CR6 AMIGO2 ARAP1 ARAP2 ARAP3 ARG ARGBPIA ARHGAP1 ARHGAP10 ARHGAP12 ARHGAP13 ARHGAP14 ARHGAP15 ARHGAP17 ARHGAP2 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP3 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP34 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP7 ARHGAP9 ARHGDIA ARHGDIB ARHGEF10 ARHGEF11 ARHGEF15 ARHGEF18 ARHGEF19 ARHGEF25 ARHGEF39 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ASCT2 BAIAP2 BAIAP2L1 BCH BCR BCR1 BORG4 BORG5 BRK1 C11orf59 C17orf1 C17orf1B C3orf10 C5orf5 C9orf100 CAMGAP1 CAV CAV1 CDC42 CDC42BPA CDC42EP1 CDC42EP4 CDC42GAP CDEP CDGAP CENTD1 CENTD2 CENTD3 CEP1 CEP4 CG1 CHN CHN1 CHN2 CIT COOL1 COOL2 CR16 CRIK CYBA CYBB CYFIP1 CYFIP2 D22S11 DBL DEF6 DEPDC1B DEPDC2 DIAP3 DIAPH3 DLC1 DOCK1 DOCK10 DOCK11 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK7 DOCK8 DOCK9 DPK DUET DUO ECK ECT2 EDMD EMD EPHA2 ERBB2IP ERBIN ESYT1 FAM13A FAM13A1 FAM13B FAM13B1 FAM62A FARP1 FARP2 FERMT2 FGD5 FILGAP FMNL FMNL1 FNBP2 FNRB FRL1 GARRE1 GDIA1 GDIA2 GDID4 GEFT GIT1 GIT2 GMIP GNA13 GRAF GRAF2 GRAF3 GRB1 GRF1 GRF2 GRIT GRLF1 HAPIP HEM1 HEM2 HMHA1 IBP IMD2 IQGAP1 IQGAP2 IQGAP3 IRAS IRTKS ITGB1 JAG1 JAGL1 JIK KALRN KDS KIAA0004 KIAA0006 KIAA0051 KIAA0053 KIAA0068 KIAA0131 KIAA0142 KIAA0148 KIAA0209 KIAA0223 KIAA0269 KIAA0294 KIAA0299 KIAA0355 KIAA0362 KIAA0380 KIAA0411 KIAA0451 KIAA0456 KIAA0521 KIAA0580 KIAA0587 KIAA0599 KIAA0621 KIAA0640 KIAA0672 KIAA0694 KIAA0712 KIAA0716 KIAA0747 KIAA0782 KIAA0793 KIAA0900 KIAA0914 KIAA0915 KIAA0949 KIAA0975 KIAA1058 KIAA1112 KIAA1142 KIAA1156 KIAA1168 KIAA1204 KIAA1209 KIAA1225 KIAA1264 KIAA1304 KIAA1391 KIAA1395 KIAA1415 KIAA1424 KIAA1478 KIAA1501 KIAA1563 KIAA1688 KIAA1722 KIAA1723 KIAA1771 KIAA2016 KIND2 KTN1 LAMTOR1 LAP2 LBR LEMD3 M7V1 MAN1 MAP3K18 MBC2 MCAM MCF2 MCF2L MDF2 MEGAP MGCRACGAP MIG2 MOCA MOX1 MOX2 MPP7 MSE55 MSK12 MUC18 MYO9B MYR5 NAP1 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NGEF NHS NISCH NOH1 NOX1 NOX2 NOX3 NOXA1 NOXA2 NOXO1 NOXO2 OPHN1 OPHN1L OPHN3 OST P190A P41NOX P51NOX P67PHOX P85SPR PAK1 PAK2 PAK3 PAK3BP PAK4 PAK5 PAK6 PAK7 PAR6A PARD6A PARG1 PDRO PIK3CA PIK3R1 PIK3R2 PIK3R3 PIR121 PIXA PIXB PKN PKN1 PKN2 PLD1 PLD2 PLEKHC1 PLEKHC2 PLEKHC3 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG6 PREX1 PREX2 PRK1 PRK2 PRKCL1 PRKCL2 PRTPHN1 RAB7 RAB7A RAC1 RACGAP1 RALBP1 RAP1GN1 RASGRF2 RDR RDRC RGC1 RHOGAP1 RHOGAP2 RHOGAP4 RHOGAP5 RICH1 RICH2 RICS RLIP RLIP1 RLIP76 SCAR1 SCAR3 SH3BP1 SH3D20 SH3PXD1A SH3PXD4 SH3PXD5 SLC1A5 SNAP23 SNX26 SOS1 SOS2 SPATA13 SRGAP1 SRGAP2 SRGAP2A SRGAP3 SSH3BP1 STA STARD12 STB2 STEF STK21 SWAP70 SYB3 SYDE2 TAGAP TAGAP1 TAOK3 TC25 TCGAP TFRC TIAM1 TIAM2 TIM TMEM133 TMPO TRAD TRIO VAMP3 VANGL1 VAV VAV1 VAV2 VAV3 VRK2 WAS WASF1 WASF2 WASF3 WASL WASPIP WAVE1 WAVE2 WAVE3 WICH WIP WIPF1 WIPF2 WIPF3 WIRE XTP8 YKT6 ZFYVE23 ZIZ1 ZIZ2 ZIZ3 p190ARHOGAP	Homo sapiens (human)
RAB geranylgeranylation	Geranylgeranyl transferase type-2 subunit alpha Geranylgeranyl transferase type-2 subunit beta Protein tyrosine phosphatase type IVA 2 Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A 2 Ras-related protein Rab-10 Ras-related protein Rab-11A Ras-related protein Rab-11B Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-15 Ras-related protein Rab-17 Ras-related protein Rab-18 Ras-related protein Rab-19 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-20 Ras-related protein Rab-21 Ras-related protein Rab-22A Ras-related protein Rab-23 Ras-related protein Rab-24 Ras-related protein Rab-25 Ras-related protein Rab-26 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-2A Ras-related protein Rab-2B Ras-related protein Rab-30 Ras-related protein Rab-31 Ras-related protein Rab-32 Ras-related protein Rab-33A Ras-related protein Rab-33B Ras-related protein Rab-34 Ras-related protein Rab-35 Ras-related protein Rab-36 Ras-related protein Rab-37 Ras-related protein Rab-38 Ras-related protein Rab-39A Ras-related protein Rab-39B Ras-related protein Rab-3A Ras-related protein Rab-3B Ras-related protein Rab-3C Ras-related protein Rab-3D Ras-related protein Rab-40A Ras-related protein Rab-40B Ras-related protein Rab-40C Ras-related protein Rab-41 Ras-related protein Rab-42 Ras-related protein Rab-43 Ras-related protein Rab-44 Ras-related protein Rab-4A Ras-related protein Rab-4B Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7L1 Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab-9B	A4D1S5 O00194 O14966 O95716 O95755 P20336 P20337 P20338 P20339 P20340 P24386 P26374 P51148 P51149 P51151 P51153 P51159 P53611 P57729 P57735 P59190 P61006 P61018 P61019 P61020 P61026 P61106 P62491 P62820 Q12829 Q12974 Q13636 Q13637 Q14088 Q14964 Q15286 Q15771 Q15907 Q5JT25 Q6IQ22 Q7Z6P3 Q86YS6 Q8N4Z0 Q8WUD1 Q8WXH6 Q92696 Q92930 Q969Q5 Q96AH8 Q96AX2 Q96DA2 Q96E17 Q96S21 Q9BZG1 Q9H082 Q9H0T7 Q9H0U4 Q9NP72 Q9NP90 Q9NRW1 Q9NX57 Q9UL25 Q9UL26 Q9ULC3 Q9ULW5	CATX8 CHM CHML GGTB GOV KIAA0118 MEL PRL2 PTP4A2 PTPCAAX2 RAB1 RAB10 RAB11 RAB11A RAB11B RAB12 RAB13 RAB14 RAB15 RAB16 RAB17 RAB18 RAB19 RAB19B RAB1A RAB1B RAB1C RAB2 RAB20 RAB21 RAB22 RAB22A RAB22B RAB23 RAB24 RAB25 RAB26 RAB27 RAB27A RAB27B RAB29 RAB2A RAB2B RAB30 RAB31 RAB32 RAB33A RAB33B RAB34 RAB35 RAB36 RAB37 RAB38 RAB39 RAB39A RAB39B RAB3A RAB3B RAB3C RAB3D RAB4 RAB40A RAB40B RAB40C RAB41 RAB42 RAB43 RAB44 RAB4A RAB4B RAB5 RAB5A RAB5B RAB5C RAB6 RAB6A RAB6B RAB7 RAB7A RAB7B RAB7L1 RAB8 RAB8A RAB8B RAB9 RAB9A RAB9B RAB9L RABGGTA RABGGTB RABL RABS10 RAH RARL RASL8C RAY REP1 REP2 SEC4L TCD YPT3	Homo sapiens (human)
RAB GEFs exchange GTP for GDP on RABs	14-3-3 protein epsilon ALS2 C-terminal-like protein Alsin Ankyrin repeat domain-containing protein 27 BLOC-3 complex member HPS1 BLOC-3 complex member HPS4 C-myc promoter-binding protein DENN domain-containing protein 1A DENN domain-containing protein 1B DENN domain-containing protein 1C DENN domain-containing protein 2A DENN domain-containing protein 2B DENN domain-containing protein 2C DENN domain-containing protein 2D DENN domain-containing protein 3 DENN domain-containing protein 4B DENN domain-containing protein 4C DENN domain-containing protein 5A DENN domain-containing protein 5B GTPase-activating protein and VPS9 domain-containing protein 1 Guanine nucleotide exchange factor for Rab-3A Guanine nucleotide exchange factor subunit RIC1 Myotubularin-related protein 13 Myotubularin-related protein 5 Protein DENND6A Protein DENND6B RAB6A-GEF complex partner protein 2 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rab GDP dissociation inhibitor alpha Rab GDP dissociation inhibitor beta Rab proteins geranylgeranyltransferase component A 1 Rab proteins geranylgeranyltransferase component A 2 Rab-3A-interacting protein Rab3 GTPase-activating protein catalytic subunit Rab3 GTPase-activating protein non-catalytic subunit Rab5 GDP/GTP exchange factor Ras and Rab interactor 1 Ras and Rab interactor 2 Ras and Rab interactor 3 Ras and Rab interactor-like protein Ras-related protein Rab-10 Ras-related protein Rab-12 Ras-related protein Rab-13 Ras-related protein Rab-14 Ras-related protein Rab-18 Ras-related protein Rab-1A Ras-related protein Rab-1B Ras-related protein Rab-21 Ras-related protein Rab-27A Ras-related protein Rab-27B Ras-related protein Rab-31 Ras-related protein Rab-32 Ras-related protein Rab-35 Ras-related protein Rab-38 Ras-related protein Rab-39A Ras-related protein Rab-39B Ras-related protein Rab-3A Ras-related protein Rab-5A Ras-related protein Rab-5B Ras-related protein Rab-5C Ras-related protein Rab-6A Ras-related protein Rab-6B Ras-related protein Rab-7a Ras-related protein Rab-7b Ras-related protein Rab-8A Ras-related protein Rab-8B Ras-related protein Rab-9A Ras-related protein Rab-9B Serine/threonine-protein kinase ULK1 Trafficking protein particle complex subunit 10 Trafficking protein particle complex subunit 11 Trafficking protein particle complex subunit 12 Trafficking protein particle complex subunit 13 Trafficking protein particle complex subunit 1 Trafficking protein particle complex subunit 2-like protein Trafficking protein particle complex subunit 2 Trafficking protein particle complex subunit 3 Trafficking protein particle complex subunit 4 Trafficking protein particle complex subunit 5 Trafficking protein particle complex subunit 6A Trafficking protein particle complex subunit 6B Trafficking protein particle complex subunit 8 Trafficking protein particle complex subunit 9 Vacuolar fusion protein CCZ1 homolog B Vacuolar fusion protein CCZ1 homolog Vacuolar fusion protein MON1 homolog A Vacuolar fusion protein MON1 homolog B	A2RUS2 A5PLN9 O00194 O43617 O75064 O75385 O75865 O95248 P0DI81 P20336 P20339 P20340 P24386 P26374 P31150 P31749 P31751 P48553 P50395 P51148 P51149 P51151 P51153 P51159 P57729 P61006 P61020 P61026 P61106 P62258 P62820 P78524 P86790 P86791 Q13636 Q13637 Q13671 Q14964 Q14C86 Q15042 Q15286 Q4ADV7 Q5VZ89 Q60I27 Q68D51 Q6IQ22 Q6IQ26 Q6P3S1 Q6ZS11 Q6ZUT9 Q7L1V2 Q7Z392 Q7Z401 Q86SZ2 Q86VX9 Q86WG5 Q8IUR0 Q8IV53 Q8IWF6 Q8NEG7 Q8TB24 Q8TBN0 Q8TEH3 Q8WVT3 Q8WYP3 Q92546 Q92902 Q92930 Q96AH8 Q96DA2 Q96NW4 Q96Q05 Q96Q42 Q96QF0 Q9H0U4 Q9H2M9 Q9H6A0 Q9NP72 Q9NP90 Q9NQG7 Q9NRW1 Q9UJ41 Q9UL25 Q9UL33 Q9ULE3 Q9Y243 Q9Y296 Q9Y2L5 Q9Y5R8	AKT1 AKT2 AKT3 ALS2 ALS2CL ALS2CR6 ANKRD27 BET3 BET5 C1orf218 C4orf41 C5orf44 C7orf28A C7orf28B C9orf55 C9orf55B CCZ1 CCZ1B CHM CHML CIP150 CMT4B2 DENND1A DENND1B DENND1C DENND2A DENND2B DENND2C DENND2D DENND3 DENND4A DENND4B DENND4C DENND5A DENND5B DENND6A DENND6B EHOC1 FAM116A FAM116B FAM31A FAM31B FAM31C GAPEX5 GAPVD1 GDI1 GDI2 GDIL HPS HPS1 HPS4 HSRG1 HTS1 IRLB KIAA0066 KIAA0118 KIAA0258 KIAA0476 KIAA0722 KIAA0839 KIAA0870 KIAA0872 KIAA1012 KIAA1091 KIAA1277 KIAA1432 KIAA1521 KIAA1563 KIAA1608 KIAA1667 KIAA1766 KIAA1882 MEL MON1A MON1B MTMR13 MTMR5 MUM2 MYCPBP NIBP OPHN2 PKB PKBG RAB1 RAB10 RAB12 RAB13 RAB14 RAB18 RAB1A RAB1B RAB1C RAB21 RAB22B RAB27 RAB27A RAB27B RAB31 RAB32 RAB35 RAB38 RAB39 RAB39A RAB39B RAB3A RAB3GAP RAB3GAP1 RAB3GAP2 RAB3IL1 RAB3IP RAB5 RAB5A RAB5B RAB5C RAB6 RAB6A RAB6B RAB6IP1 RAB7 RAB7A RAB7B RAB8 RAB8A RAB8B RAB9 RAB9A RAB9B RAB9L RABEX5 RABGDIA RABGDIB RABGEF1 RABIN8 RABL RAC RAP6 RASSF4 RAY REP1 REP2 RGP1 RIC1 RIN1 RIN2 RIN3 RINL SAND1 SAND2 SBDN SBF1 SBF2 SEDL ST5 TCD TMEM1 TRAMM TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC13 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9 TTC15 ULK1 XAP4 YWHAE	Homo sapiens (human)
RA biosynthesis pathway	2-aminomuconic semialdehyde dehydrogenase Alcohol dehydrogenase 1A Alcohol dehydrogenase 1C Aldehyde dehydrogenase 1A1 Aldo-keto reductase family 1 member C3 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Cellular retinoic acid-binding protein 1 Cytochrome P450 26A1 Cytochrome P450 26B1 Cytochrome P450 26C1 Dehydrogenase/reductase SDR family member 4 Dehydrogenase/reductase SDR family member 9 Epidermal retinol dehydrogenase 2 Retinal dehydrogenase 2 Retinaldehyde dehydrogenase 3 Retinol dehydrogenase 10 Retinol dehydrogenase 11 Retinol dehydrogenase 13 Retinol dehydrogenase 14 Retinol dehydrogenase 16 Retinol dehydrogenase 5 Short-chain dehydrogenase/reductase 3	O43174 O75452 O75911 O94788 P00326 P00352 P07327 P08319 P29762 P42330 P47895 Q6V0L0 Q8IZV5 Q8N3Y7 Q8NBN7 Q8TC12 Q92781 Q9BPW9 Q9BTZ2 Q9H2A2 Q9HBH5 Q9NR63	ADH1 ADH1A ADH1C ADH2 ADH3 ADH4 AKR1C3 ALDC ALDH1 ALDH12 ALDH1A1 ALDH1A2 ALDH1A3 ALDH6 ALDH8A1 ARSDR1 CRABP1 CYP26 CYP26A1 CYP26A2 CYP26B1 CYP26C1 DDH1 DHRS3 DHRS4 DHRS9 HSD17B5 HSD17B9 KIAA0119 P450RAI1 P450RAI2 PAN2 PGFS PSDR1 PUMB1 RALDH2 RBP5 RDH1 RDH10 RDH11 RDH13 RDH14 RDH15 RDH16 RDH17 RDH5 RDHE2 RODH4 SDR16C1 SDR16C4 SDR16C5 SDR25C2 SDR7C1 SDR7C3 SDR7C4 SDR9C4 SDR9C5 SDR9C8	Homo sapiens (human)
Pyruvate metabolism	Alanine aminotransferase 1 L-lactate dehydrogenase A chain L-lactate dehydrogenase A-like 6A L-lactate dehydrogenase A-like 6B L-lactate dehydrogenase B chain L-lactate dehydrogenase C chain Lactoylglutathione lyase Mitochondrial pyruvate carrier 1-like protein Mitochondrial pyruvate carrier 1 Mitochondrial pyruvate carrier 2 NAD-dependent malic enzyme, mitochondrial NADP-dependent malic enzyme, mitochondrial NADP-dependent malic enzyme Oxaloacetate decarboxylase, mitochondrial Pyruvate carboxylase, mitochondrial Voltage-dependent anion-selective channel protein 1	O95563 P00338 P07195 P07864 P0DKB6 P11498 P21796 P23368 P24298 P48163 Q04760 Q16798 Q6P587 Q6ZMR3 Q9BYZ2 Q9Y5U8	AAT1 BRP44 BRP44L C16orf36 FAHD1 GLO1 GPT GPT1 LDH3 LDHA LDHAL6 LDHAL6A LDHAL6B LDHB LDHC LDHL LDHL2 LDHX ME1 ME2 ME3 MPC1 MPC1L MPC2 PC VDAC VDAC1 YISKL	Homo sapiens (human)
Pyroptosis	Apoptosis regulator BAX Bcl-2 homologous antagonist/killer Caspase-1 Caspase-3 Caspase-4 Caspase-5 Cellular tumor antigen p53 Charged multivesicular body protein 2a Charged multivesicular body protein 2b Charged multivesicular body protein 3 Charged multivesicular body protein 4a Charged multivesicular body protein 4b Charged multivesicular body protein 4c Charged multivesicular body protein 6 Charged multivesicular body protein 7 Cytochrome c Gasdermin-D Gasdermin-E Granzyme B High mobility group protein B1 Interferon regulatory factor 1 Interferon regulatory factor 2 Interleukin-1 alpha Interleukin-1 beta Interleukin-18 Neutrophil elastase Tumor protein 63	O43633 O60443 P01583 P01584 P04637 P08246 P09429 P10144 P10914 P14316 P29466 P42574 P49662 P51878 P57764 P99999 Q07812 Q14116 Q16611 Q8WUX9 Q96CF2 Q96FZ7 Q9BY43 Q9H3D4 Q9H444 Q9UQN3 Q9Y3E7	BAK BAK1 BAX BC2 BCL2L4 BCL2L7 C14orf123 C20orf178 CASP1 CASP3 CASP4 CASP5 CDN1 CGI149 CGL1 CHMP2 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 CPP32 CSPB CTLA1 CYC CYCS DFNA5 DFNA5L ELA2 ELANE GRB GSDMD GSDMDC1 GSDME GZMB HMG1 HMGB1 ICERE1 ICH2 ICH3 IGIF IL18 IL1A IL1B IL1BC IL1BCE IL1F1 IL1F2 IL1F4 IRF1 IRF2 KET NEDF P53 P63 P73H P73L SHAX1 SHAX2 SHAX3 TP53 TP63 TP73L VPS20 VPS24	Homo sapiens (human)
Pyrophosphate hydrolysis	Inorganic pyrophosphatase 2, mitochondrial Inorganic pyrophosphatase Phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Q15181 Q9H008 Q9H2U2	IOPPP LHPP PP PPA1 PPA2	Homo sapiens (human)
Pyrimidine salvage	Cytidine deaminase Deoxycytidine kinase Pseudouridine-5'-phosphatase Thymidine kinase 2, mitochondrial Thymidine kinase, cytosolic Thymidine phosphorylase Uridine phosphorylase 1 Uridine phosphorylase 2 Uridine-cytidine kinase 1 Uridine-cytidine kinase 2 Uridine-cytidine kinase-like 1	O00142 O95045 P04183 P19971 P27707 P32320 Q08623 Q16831 Q9BZX2 Q9HA47 Q9NWZ5	CDA CDD DCK DXF68S1E ECGF1 FAM16AX GS1 HDHD1 HDHD1A PUDP TK1 TK2 TYMP UCK1 UCK2 UCKL1 UMPK UP UPP1 UPP2 URK1 URKL1	Homo sapiens (human)
Pyrimidine catabolism	5'(3')-deoxyribonucleotidase, cytosolic type 5'(3')-deoxyribonucleotidase, mitochondrial 5'-nucleotidase Alanine--glyoxylate aminotransferase 2, mitochondrial Beta-ureidopropionase Cytosolic 5'-nucleotidase 1A Dihydropyrimidinase Dihydropyrimidine dehydrogenase [NADP(+)] Thymidine phosphorylase Uridine phosphorylase 1 Uridine phosphorylase 2	O95045 P19971 P21589 Q12882 Q14117 Q16831 Q8TCD5 Q9BXI3 Q9BYV1 Q9NPB1 Q9UBR1	AGT2 AGXT2 BUP1 DNT1 DNT2 DPYD DPYS ECGF1 NT5 NT5C NT5C1A NT5E NT5M NTE TYMP UMPH2 UP UPB1 UPP1 UPP2	Homo sapiens (human)
Pyrimidine biosynthesis	Dihydroorotate dehydrogenase (quinone), mitochondrial Multifunctional protein CAD Uridine 5'-monophosphate synthase	P11172 P27708 Q02127	CAD DHODH UMPS	Homo sapiens (human)
Purinergic signaling in leishmaniasis infection	5'-nucleotidase Apoptosis-associated speck-like protein containing a CARD C3a anaphylatoxin chemotactic receptor Caspase-1 Cathepsin G Complement C3 Ectonucleoside triphosphate diphosphohydrolase 1 Gasdermin-D Heat shock protein HSP 90-beta Heme oxygenase 1 Interleukin-1 alpha Interleukin-1 beta Interleukin-18 NACHT, LRR and PYD domains-containing protein 3 Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p105 subunit Nucleoside diphosphate phosphatase ENTPD5 P2X purinoceptor 4 P2X purinoceptor 7 Proline-serine-threonine phosphatase-interacting protein 1 Protein SGT1 homolog Pyrin Thioredoxin-interacting protein Thioredoxin Transcription factor p65	O15553 O43586 O75356 P01024 P01583 P01584 P08238 P08311 P09601 P10599 P19838 P21589 P29466 P49961 P57764 Q00653 Q04206 Q14116 Q16581 Q96P20 Q99571 Q99572 Q9H3M7 Q9ULZ3 Q9Y2Z0	ASC AZ3B C1orf7 C3 C3AR1 C3R1 CARD5 CASP1 CD2BP1 CD39 CD39L4 CIAS1 CPAMD1 CTSG DFNA5L ENTPD1 ENTPD5 GSDMD GSDMDC1 HMOX1 HNFAG09 HO HO1 HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB IGIF IL18 IL1A IL1B IL1BC IL1BCE IL1F1 IL1F2 IL1F4 LYT10 MEF MEFV NALP3 NFKB1 NFKB2 NFKB3 NLRP3 NT5 NT5E NTE P2RX4 P2RX7 PCPH PSTPIP1 PYCARD PYPAF1 RELA SUGT1 TMS1 TRDX TRIM20 TRX TRX1 TXN TXNIP VDUP1	Homo sapiens (human)
Purine salvage	AMP deaminase 1 AMP deaminase 2 AMP deaminase 3 Adenine phosphoribosyltransferase Adenosine deaminase-like protein Adenosine deaminase Adenosine kinase Deoxycytidine kinase Deoxyguanosine kinase, mitochondrial GMP reductase 1 GMP reductase 2 Hypoxanthine-guanine phosphoribosyltransferase Purine nucleoside phosphorylase	P00491 P00492 P00813 P07741 P23109 P27707 P36959 P55263 Q01432 Q01433 Q16854 Q6DHV7 Q9P2T1	ADA ADA1 ADAL ADAL1 ADK AMPD1 AMPD2 AMPD3 APRT DCK DGK DGUOK GMPR GMPR1 GMPR2 HPRT HPRT1 NP PNP	Homo sapiens (human)
Purine ribonucleoside monophosphate biosynthesis	Adenylosuccinate lyase Adenylosuccinate synthetase isozyme 1 Adenylosuccinate synthetase isozyme 2 Amidophosphoribosyltransferase Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase Bifunctional purine biosynthesis protein ATIC GMP synthase [glutamine-hydrolyzing] Inosine-5'-monophosphate dehydrogenase 1 Inosine-5'-monophosphate dehydrogenase 2 Phosphoribosylformylglycinamidine synthase Trifunctional purine biosynthetic protein adenosine-3	O15067 P12268 P20839 P22102 P22234 P30520 P30566 P31939 P49915 Q06203 Q8N142	ADE2 ADSL ADSS ADSS1 ADSS2 ADSSL1 AIRC AMPS ATIC GART GMPS GPAT IMPD1 IMPD2 IMPDH1 IMPDH2 KIAA0361 PAICS PAIS PFAS PGFT PPAT PRGS PURH	Homo sapiens (human)
Purine catabolism	5'(3')-deoxyribonucleotidase, cytosolic type 5'-nucleotidase 5-hydroxymethyl-dUMP N-hydrolase Cytosolic 5'-nucleotidase 1A Cytosolic 5'-nucleotidase 1B Cytosolic purine 5'-nucleotidase Guanine deaminase Inosine triphosphate pyrophosphatase Purine nucleoside phosphorylase Xanthine dehydrogenase/oxidase	O43598 P00491 P21589 P47989 P49902 Q8TCD5 Q96P26 Q9BXI3 Q9BY32 Q9Y2T3	AIRP C20orf37 C6orf108 DNPH1 DNT1 GDA ITPA KIAA1258 NP NT5 NT5B NT5C NT5C1A NT5C1B NT5C2 NT5CP NT5E NTE PNP PNT5 RCL UMPH2 XDH XDHA	Homo sapiens (human)
Proton/oligopeptide cotransporters	Solute carrier family 15 member 1 Solute carrier family 15 member 2 Solute carrier family 15 member 3 Solute carrier family 15 member 4	P46059 Q16348 Q8IY34 Q8N697	OCTP PEPT1 PEPT2 PHT1 PHT2 PTR3 PTR4 SLC15A1 SLC15A2 SLC15A3 SLC15A4	Homo sapiens (human)
Proton-coupled neutral amino acid transporters	Proton-coupled amino acid transporter 1 Proton-coupled amino acid transporter 2	Q495M3 Q7Z2H8	PAT1 PAT2 SLC36A1 SLC36A2 TRAMD1	Homo sapiens (human)
Proton-coupled monocarboxylate transport	Basigin Embigin Monocarboxylate transporter 1 Monocarboxylate transporter 2 Monocarboxylate transporter 3 Monocarboxylate transporter 4	O15427 O60669 O95907 P35613 P53985 Q6PCB8	BSG EMB MCT1 MCT2 MCT3 MCT4 SLC16A1 SLC16A3 SLC16A7 SLC16A8	Homo sapiens (human)
Protein repair	Methionine-R-sulfoxide reductase B1 Methionine-R-sulfoxide reductase B2, mitochondrial Methionine-R-sulfoxide reductase B3 Mitochondrial peptide methionine sulfoxide reductase Protein-L-isoaspartate(D-aspartate) O-methyltransferase Thioredoxin	P10599 P22061 Q8IXL7 Q9NZV6 Q9UJ68 Q9Y3D2	CBS-1 MSRA MSRB MSRB1 MSRB2 MSRB3 PCMT1 SEPX1 TRDX TRX TRX1 TXN	Homo sapiens (human)
Protein methylation	Calmodulin-1 Calmodulin-lysine N-methyltransferase DNA/RNA-binding protein KIN17 EEF1A lysine methyltransferase 1 EEF1A lysine methyltransferase 2 Electron transfer flavoprotein beta subunit lysine methyltransferase Electron transfer flavoprotein subunit beta Elongation factor 1-alpha 1 Elongation factor 2 Heat shock cognate 71 kDa protein Methyltransferase-like protein 22 Protein N-lysine methyltransferase METTL21A Protein N-lysine methyltransferase METTL21D Protein arginine N-methyltransferase 3 Protein-lysine N-methyltransferase EEF2KMT Small ribosomal subunit protein uS5 Transitional endoplasmic reticulum ATPase	O60678 O60870 P0DP23 P11142 P13639 P15880 P38117 P55072 P68104 Q5JPI9 Q7Z624 Q8IXQ9 Q8WVE0 Q8WXB1 Q96G04 Q9BUU2 Q9H867	BTCD C10orf138 C12orf72 C14orf138 C16orf68 C2orf34 CALM CALM1 CAM CAM1 CAMKMT CLNMT EEF1A EEF1A1 EEF1AKMT1 EEF1AKMT2 EEF2 EEF2KMT EF1A EF2 ETFB ETFBKMT FAM119A FAM86A HCA557B HEL-220 HEL-S-70 HRMT1L3 HSC70 HSP73 HSPA10 HSPA8 KIN KIN17 LENG7 METTL10 METTL20 METTL21A METTL21D METTL22 N6AMT2 PRMT3 RPS2 RPS4 VCP VCPKMT	Homo sapiens (human)
Protein lipoylation	Acyl carrier protein, mitochondrial Adrenodoxin, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Glycine cleavage system H protein, mitochondrial Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Lipoyl amidotransferase LIPT1, mitochondrial Lipoyl synthase, mitochondrial NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Octanoyl-[acyl-carrier-protein]	A6NK58 O14561 O43766 P10109 P10515 P11182 P23434 P36957 Q9UMS0 Q9Y234	ADX BCATE2 BCKDHE2 DBT DLAT DLST DLTA DLTS FDX1 GCSH HIRIP5 LAS LIAS LIPT1 LIPT2 NDUFAB1 NFU1	Homo sapiens (human)
Protein hydroxylation	2-oxoglutarate and iron-dependent oxygenase JMJD4 Aspartyl/asparaginyl beta-hydroxylase Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 Bifunctional peptidase and arginyl-hydroxylase JMJD5 Coagulation factor IX Developmentally-regulated GTP-binding protein 1 Developmentally-regulated GTP-binding protein 2 Eukaryotic peptide chain release factor subunit 1 Large ribosomal subunit protein uL15 Large ribosomal subunit protein uL2 Prolyl 3-hydroxylase OGFOD1 RCC1 domain-containing protein 1 RWD domain-containing protein 1 Ribosomal oxygenase 1 Ribosomal oxygenase 2 Small ribosomal subunit protein eS6 Small ribosomal subunit protein uS12 Splicing factor U2AF 65 kDa subunit Zinc finger CCCH domain-containing protein 15	A6NED2 P00740 P0C870 P26368 P46776 P55039 P62266 P62495 P62753 P62917 Q12797 Q6NYC1 Q8IUF8 Q8N371 Q8N543 Q8WU90 Q9H446 Q9H6W3 Q9H9V9 Q9Y295	ASPH BAH C14orf169 DFRP1 DFRP2 DRG1 DRG2 ERF1 ETF1 F9 JMJD4 JMJD5 JMJD6 JMJD7 KDM8 KIAA0585 KIAA1612 LEREPO4 MAPJD MDIG MINA MINA53 NEDD3 NO52 NO66 OGFOD1 PSR PTDSR RCCD1 RF1 RIOX1 RIOX2 RPL27A RPL8 RPS23 RPS6 RWDD1 SUP45L1 TPA1 U2AF2 U2AF65 ZC3H15	Homo sapiens (human)

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