GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **751 - 775** of **2090** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▼
Tight junction interactions	Claudin-10 Claudin-11 Claudin-12 Claudin-14 Claudin-15 Claudin-16 Claudin-17 Claudin-18 Claudin-19 Claudin-1 Claudin-20 Claudin-22 Claudin-23 Claudin-2 Claudin-3 Claudin-4 Claudin-5 Claudin-6 Claudin-7 Claudin-8 Claudin-9 Envelope small membrane protein InaD-like protein Junctional adhesion molecule A Partitioning defective 3 homolog Partitioning defective 6 homolog alpha Partitioning defective 6 homolog beta Partitioning defective 6 homolog gamma Protein PALS1 Protein crumbs homolog 3 Protein kinase C iota type	O00501 O14493 O15551 O75508 O95471 O95484 O95500 O95832 P0DTC4 P41743 P56746 P56747 P56748 P56749 P56750 P56856 P56880 P57739 P78369 Q8N3R9 Q8N6F1 Q8N7P3 Q8NI35 Q8TEW0 Q96B33 Q9BUF7 Q9BYG4 Q9BYG5 Q9NPB6 Q9Y5I7 Q9Y624	AWAL C7orf1 CEPTRL2 CIPP CLD1 CLDN1 CLDN10 CLDN11 CLDN12 CLDN14 CLDN15 CLDN16 CLDN17 CLDN18 CLDN19 CLDN2 CLDN20 CLDN22 CLDN23 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CPER CPETR1 CPETR2 CPETRL2 CRB3 DXS1179E E F11R INADL JAM1 JCAM MPP5 OSP OTM PALS1 PAR3 PAR3A PAR6A PAR6B PAR6G PARD3 PARD6A PARD6B PARD6G PATJ PCLN1 PRKCI SEMP1 TMVCF WBSCR8	Homo sapiens (human)
Defective Mismatch Repair Associated With MSH6	DNA mismatch repair protein Msh2 DNA mismatch repair protein Msh6	P43246 P52701	GTBP MSH2 MSH6	Homo sapiens (human)
Defective MTRR causes HMAE	Methionine synthase reductase Methionine synthase	Q99707 Q9UBK8	MTR MTRR	Homo sapiens (human)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 1 Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic spindle assembly checkpoint protein MAD2A Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A5LHX3 O00231 O00232 O00233 O00487 O00762 O14818 O43242 O43684 O60566 O75832 P06493 P0CG47 P0CG48 P17980 P20248 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P30260 P35998 P40306 P43686 P48556 P49720 P49721 P51665 P51668 P51965 P55036 P60006 P60896 P60900 P61289 P62191 P62195 P62333 P62979 P62987 P78396 Q06323 Q12834 Q13042 Q13200 Q13257 Q14997 Q15008 Q16401 Q16763 Q8NHZ8 Q8TAA3 Q92530 Q96DE5 Q99436 Q99460 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UL46 Q9UM13 Q9UNM6	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 BUB1B BUB3 BUBR1 C10orf104 C11orf51 C7orf76 C9orf17 CCN1 CCNA CCNA1 CCNA2 CDC16 CDC2 CDC20 CDC23 CDC26 CDC27 CDC28A CDK1 CDKN1 CENP-27 D0S1430E D17S978E DSS1 E2EPF HC2 HC3 HC8 HC9 HSPC IFI5111 KIAA0072 KIAA0077 KIAA0107 KIAA1406 LMP10 LMP2 LMP7 LMPX LMPY MAD2 MAD2L1 MAD3L MB1 MCB1 MECL1 MIP224 MOV34L MSS1 NU P34CDC2 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RING10 RING12 RPS27A SEM1 SFT SHFDG1 SHFM1 SSK1 SUG1 SUG2 TBP1 TBP7 TRAP2 TSG24 UBA52 UBA80 UBB UBC UBC5A UBCEP1 UBCEP2 UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S X Y Y2 Z	Homo sapiens (human)
Signaling by cytosolic FGFR1 fusion mutants	Breakpoint cluster region protein Centrosomal protein 43 Cleavage and polyadenylation specificity factor subunit 6 FGFR1 oncogene partner 2 GRB2-associated-binding protein 2 Homeobox protein cut-like 1 Leucine-rich repeat flightless-interacting protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Transcription intermediary factor 1-alpha Unconventional myosin-XVIIIa Zinc finger MYM-type protein 2	O15164 O95684 P11274 P27986 P39880 P40763 P42224 P42229 P42336 P51692 Q16630 Q32MZ4 Q92614 Q9NVK5 Q9UBW7 Q9UQC2	APRF BCR BCR1 CD245 CEP43 CFIM68 CPSF6 CUTL1 CUX1 D22S11 FGFR1OP FGFR1OP2 FIM FOP GAB2 GCF2 GRB1 KIAA0216 KIAA0571 LRRFIP1 MYO18A MYSPDZ PIK3CA PIK3R1 RAMP RNF82 STAT1 STAT3 STAT5 STAT5A STAT5B TIAF1 TIF1 TIF1A TRIM24 TRIP ZMYM2 ZNF198	Homo sapiens (human)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	Inhibitor of nuclear factor kappa-B kinase subunit epsilon Interferon regulatory factor 3 Interferon regulatory factor 7 Lymphocyte antigen 96 Monocyte differentiation antigen CD14 Optineurin Polyubiquitin-B Polyubiquitin-C Serine/threonine-protein kinase TBK1 TIR domain-containing adapter molecule 1 TIR domain-containing adapter molecule 2 TNF receptor-associated factor 3 TRAF family member-associated NF-kappa-B activator Toll-like receptor 4 Tyrosine-protein phosphatase non-receptor type 11 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00206 P08571 P0CG47 P0CG48 P62979 P62987 Q06124 Q13114 Q14164 Q14653 Q86XR7 Q8IUC6 Q92844 Q92985 Q96CV9 Q9UHD2 Q9Y6Y9	CAP-1 CD14 CRAF1 ESOP1 FIP2 GLC1E HIP7 HYPL IKBKE IKKE IKKI IRF3 IRF7 ITRAF KIAA0151 LY96 MD2 NAK NRP OPTN PRVTIRB PTP2C PTPN11 RPS27A SHPTP2 TANK TBK1 TICAM1 TICAM2 TIRAP3 TIRP TLR4 TRAF2 TRAF3 TRAFAMN TRAM TRIF UBA52 UBA80 UBB UBC UBCEP1 UBCEP2	Homo sapiens (human)
Beta oxidation of myristoyl-CoA to lauroyl-CoA	Long-chain specific acyl-CoA dehydrogenase, mitochondrial Trifunctional enzyme subunit alpha, mitochondrial Trifunctional enzyme subunit beta, mitochondrial	P28330 P40939 P55084	ACADL HADH HADHA HADHB	Homo sapiens (human)
Propionyl-CoA catabolism	Methylmalonic aciduria type A protein, mitochondrial Methylmalonyl-CoA epimerase, mitochondrial Methylmalonyl-CoA mutase, mitochondrial Propionyl-CoA carboxylase alpha chain, mitochondrial Propionyl-CoA carboxylase beta chain, mitochondrial	P05165 P05166 P22033 Q8IVH4 Q96PE7	MCEE MMAA MMUT MUT PCCA PCCB	Homo sapiens (human)
Uptake of dietary cobalamins into enterocytes	Chymotrypsinogen B2 Chymotrypsinogen B Cobalamin binding intrinsic factor Cubilin Lysosomal cobalamin transport escort protein LMBD1 Lysosomal cobalamin transporter ABCD4 Protein amnionless Serine protease 1 Transcobalamin-1 Trypsin-3	O14678 O60494 P07477 P17538 P20061 P27352 P35030 Q6GPI1 Q9BXJ7 Q9NUN5	ABCD4 AMN C6orf209 CBLIF CTRB CTRB1 CTRB2 CUBN GIF IFCR IFMH LMBRD1 NESI PRSS1 PRSS3 PRSS4 PXMP1L TC1 TCN1 TRP1 TRY1 TRY3 TRY4 TRYP1	Homo sapiens (human)
Downstream TCR signaling	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 3-phosphoinositide-dependent protein kinase 1 B-cell lymphoma/leukemia 10 Caspase recruitment domain-containing protein 11 Cullin-1 F-box/WD repeat-containing protein 11 F-box/WD repeat-containing protein 1A HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Mitogen-activated protein kinase kinase kinase 7 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Polyubiquitin-B Polyubiquitin-C Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Protein kinase C theta type Receptor-interacting serine/threonine-protein kinase 2 S-phase kinase-associated protein 1 T cell receptor alpha chain constant T cell receptor alpha variable 19 T cell receptor alpha variable 29/delta variable 5 T cell receptor alpha variable 8-4 T cell receptor beta constant 1 T cell receptor beta variable 12-3 T cell receptor beta variable 7-9 T-cell receptor-associated transmembrane adapter 1 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TNF receptor-associated factor 6 Transcription factor p65 Tyrosine-protein kinase Lck Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 R1 Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A0A6YYK7 A5LHX3 O00231 O00232 O00233 O00459 O00487 O14818 O14920 O15111 O15530 O43242 O43318 O43353 O75832 O95999 P01730 P01733 P01737 P01848 P01850 P01903 P01906 P01909 P01911 P01920 P04234 P04435 P04437 P04440 P05538 P06239 P07766 P09693 P0CG47 P0CG48 P13762 P17980 P19838 P20036 P20618 P25786 P25787 P25788 P25789 P25963 P27986 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P42336 P42338 P43686 P48556 P49427 P49720 P49721 P51665 P51668 P55036 P60484 P60896 P60900 P61088 P61289 P62191 P62195 P62333 P62837 P62979 P62987 P63208 P79483 Q04206 Q04759 Q06323 Q13200 Q13404 Q13616 Q14997 Q15008 Q16401 Q30154 Q6PIZ9 Q8TAA3 Q92530 Q92835 Q99436 Q99460 Q9BXL7 Q9NYJ8 Q9UDY8 Q9UKB1 Q9UL46 Q9UNM6 Q9Y297 Q9Y4K3 Q9Y6K9	BCL10 BLU BTRC BTRCP BTRCP2 C7orf76 CARD11 CARDIAK CARMA1 CD3D CD3E CD3G CD4 CDC34 CHUK CIPER CLAP CROC1 CUL1 DSS1 EMC19 FBW1A FBW1B FBXW11 FBXW1A FBXW1B FIP3 GRB1 HC2 HC3 HC8 HC9 HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLASB HSPC IFI5111 IKBA IKBKB IKBKG IKKA IKKB INPP5D KIAA0072 KIAA0077 KIAA0107 KIAA0696 KIAA0733 LCK LMP10 LMP2 LMP7 LMPX LMPY MAD3 MALT1 MAP3K7 MAP3K7IP2 MB1 MCB1 MECL1 MIP224 MLT MMAC1 MOV34L MSS1 NEMO NFKB1 NFKB3 NFKBI NFKBIA NU OCP2 PDK1 PDPK1 PFAAP4 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 POH1 PRKCQ PRKCT PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PTEN PUBC1 RELA RICK RING10 RING12 RIP2 RIPK2 RNF85 RPS27A SEM1 SFT SHFDG1 SHFM1 SHIP SHIP1 SKP1 SKP1A SUG1 SUG2 T3D T3E T3G TAB2 TAK1 TBP1 TBP7 TCEB1L TCF16 TCRA TCRBV12S3 TCRBV8S1 TCRIM TEP1 TRAC TRAF6 TRAP2 TRAT1 TRAV19 TRAV29DV5 TRAV8-4 TRBC1 TRBV12-3 TRBV7-9 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBCEP1 UBCEP2 UBCH3 UBCH4 UBCH5 UBCH5A UBCH5B UBE2D1 UBE2D2 UBE2N UBE2R1 UBE2V UBE2V1 UEV1 X Y Y2 Z	Homo sapiens (human)
Interaction between PHLDA1 and AURKA	Aurora kinase A Pleckstrin homology-like domain family A member 1	O14965 Q8WV24	AIK AIRK1 ARK1 AURA AURKA AYK1 BTAK IAK1 PHLDA1 PHRIP STK15 STK6 TDAG51	Homo sapiens (human)
Mitochondrial transcription initiation	DNA-directed RNA polymerase, mitochondrial Dimethyladenosine transferase 2, mitochondrial Transcription factor A, mitochondrial	O00411 Q00059 Q9H5Q4	NS5ATP5 POLRMT TCF6 TCF6L2 TFAM TFB2M	Homo sapiens (human)
Activation of Ca-permeable Kainate Receptor	Calmodulin-1 Disks large homolog 1 Disks large homolog 3 Disks large homolog 4 Glutamate receptor ionotropic, kainate 1 Glutamate receptor ionotropic, kainate 2 Glutamate receptor ionotropic, kainate 3 Glutamate receptor ionotropic, kainate 4 Glutamate receptor ionotropic, kainate 5 Neurocalcin-delta	P0DP23 P39086 P61601 P78352 Q12959 Q13002 Q13003 Q16099 Q16478 Q92796	CALM CALM1 CAM CAM1 DLG1 DLG3 DLG4 GLUR5 GLUR6 GLUR7 GRIK GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 KIAA1232 NCALD PSD95	Homo sapiens (human)
RHOB GTPase cycle	A-kinase anchor protein 13 Actin, alpha cardiac muscle 1 Active breakpoint cluster region-related protein Anillin Ankyrin repeat domain-containing protein SOWAHC Breakpoint cluster region protein Caveolae-associated protein 1 Caveolin-1 Cell surface glycoprotein MUC18 Citron Rho-interacting kinase DEP domain-containing protein 1B Disheveled-associated activator of morphogenesis 1 Erbin Flotillin-1 Flotillin-2 Guanine nucleotide exchange factor DBS Guanine nucleotide exchange factor VAV2 Junction plakoglobin Neuroepithelial cell-transforming gene 1 protein Oligophrenin-1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Protein ECT2 Protein diaphanous homolog 1 Protein diaphanous homolog 3 Proto-oncogene DBL Protocadherin-7 Rac GTPase-activating protein 1 Ras GTPase-activating-like protein IQGAP3 Rho GDP-dissociation inhibitor 3 Rho GTPase-activating protein 1 Rho GTPase-activating protein 21 Rho GTPase-activating protein 26 Rho GTPase-activating protein 32 Rho GTPase-activating protein 35 Rho GTPase-activating protein 39 Rho GTPase-activating protein 5 Rho GTPase-activating protein 7 Rho guanine nucleotide exchange factor 10-like protein Rho guanine nucleotide exchange factor 10 Rho guanine nucleotide exchange factor 11 Rho guanine nucleotide exchange factor 12 Rho guanine nucleotide exchange factor 17 Rho guanine nucleotide exchange factor 1 Rho guanine nucleotide exchange factor 25 Rho guanine nucleotide exchange factor 28 Rho guanine nucleotide exchange factor 2 Rho guanine nucleotide exchange factor 3 Rho guanine nucleotide exchange factor 5 Rho-associated protein kinase 1 Rho-associated protein kinase 2 Rho-related GTP-binding protein RhoB Rhophilin-2 Rhotekin STE20-like serine/threonine-protein kinase Serine/threonine-protein kinase 10 Serine/threonine-protein kinase N1 Serine/threonine-protein kinase N2 Serine/threonine-protein kinase N3 StAR-related lipid transfer protein 13 StAR-related lipid transfer protein 8 Stomatin Synaptosomal-associated protein 23 Tight junction protein ZO-2 Transferrin receptor protein 1 Unconventional myosin-IXa Unconventional myosin-IXb Vang-like protein 1 Vesicle-associated membrane protein 3	A7KAX9 B2RTY4 O00161 O00459 O14578 O15013 O15068 O15085 O60245 O60610 O60890 O75116 O75955 O94804 P02786 P10911 P11274 P14923 P27105 P27986 P43121 P52735 P62745 P68032 Q03135 Q07960 Q12774 Q12802 Q12979 Q13017 Q13459 Q13464 Q14254 Q15836 Q16512 Q16513 Q53LP3 Q5T5U3 Q6NZI2 Q6P5Z2 Q7Z628 Q86VI3 Q86VW2 Q8IUC4 Q8N1W1 Q8TAA9 Q8TCU6 Q8WUY9 Q92502 Q92888 Q92974 Q96PE2 Q96QB1 Q96RT1 Q99819 Q9BST9 Q9C0H5 Q9H0H5 Q9H2G2 Q9H8V3 Q9HCE6 Q9NQW6 Q9NR81 Q9NRY4 Q9NSV4 Q9NZN5 Q9UDY2 Q9UNA1 Q9Y3M8 Q9Y4D1	ABR ACTC ACTC1 AKAP13 ANKRD57 ANLN ARH6 ARHB ARHGAP1 ARHGAP10 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 ARHGAP7 ARHGDIG ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF17 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF5 ARHGEF8 BCR BCR1 BHPCDH BND7 BRX C2orf26 CAV CAV1 CAVIN1 CDC42GAP CIT CRIK CTNNG D22S11 DAAM1 DBL DEPDC1B DIAP1 DIAP3 DIAPH1 DIAPH3 DLC1 DLC2 DLC3 DP3 ECT2 EPB72 ERBB2IP ERBIN ESA1 FLOT1 FLOT2 GEFT GRAF GRB1 GRF1 GRINCHGEF GRIT GRLF1 GT650 HT31 IQGAP3 JUP KIAA0189 KIAA0204 KIAA0294 KIAA0337 KIAA0362 KIAA0380 KIAA0382 KIAA0619 KIAA0621 KIAA0651 KIAA0666 KIAA0712 KIAA0949 KIAA1225 KIAA1415 KIAA1424 KIAA1478 KIAA1626 KIAA1688 KIAA1722 KIAA1723 KIAA1998 LAP2 LARG LBC LFP40 LOK M17S1 MCAM MCF2 MCF2L MGCRACGAP MUC18 MYO9A MYO9B MYR5 MYR7 NET1 OPHN1 OPHN1L OST P190A PAK1 PCDH7 PIK3R1 PIK3R2 PKN PKN1 PKN2 PKN3 PKNBETA PREX1 PRK1 PRK2 PRKCL1 PRKCL2 PTRF RACGAP1 RGNEF RHOB RHOGAP1 RHOGAP5 RHPN2 RICS ROCK1 ROCK2 RTKN RTKN1 SLK SNAP23 SOWAHC STARD12 STARD13 STARD8 STB2 STK10 STK2 STK21 STOM SYB3 TEM4 TFRC TIM TJP2 VAMP3 VANGL1 VAV2 X104 XTP8 ZO2 p190ARHOGAP	Homo sapiens (human)
Senescence-Associated Secretory Phenotype (SASP)	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 CCAAT/enhancer-binding protein beta Cell division cycle protein 16 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 inhibitor C Cyclin-dependent kinase 4 inhibitor D Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor 2A Fizzy-related protein homolog Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Homeobox protein VENTX Insulin-like growth factor-binding protein 7 Interleukin-1 alpha Interleukin-6 Interleukin-8 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 7 Nuclear factor NF-kappa-B p105 subunit Polyubiquitin-B Polyubiquitin-C Protein c-Fos Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-2 Ribosomal protein S6 kinase alpha-3 Signal transducer and activator of transcription 3 Transcription factor Jun Transcription factor p65 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00762 O60814 O95231 P01100 P01583 P04908 P05231 P05412 P06899 P0C5Y9 P0CG47 P0CG48 P10145 P11802 P16104 P17676 P19838 P20248 P20671 P23527 P24941 P27361 P28482 P30260 P33778 P38936 P40763 P42771 P42772 P42773 P46527 P51668 P51812 P51965 P55273 P57053 P58876 P60006 P62805 P62807 P62979 P62987 P68431 P78396 P84243 Q00534 Q04206 Q13042 Q13164 Q15349 Q15418 Q16270 Q16763 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q8NHZ8 Q93077 Q93079 Q96A08 Q96DE5 Q96KQ7 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9H1A4 Q9H9B1 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM11 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 APRF BAT8 BMK1 C10orf104 C11orf51 C6orf30 C9orf17 CAP20 CCN1 CCNA CCNA1 CCNA2 CDC16 CDC23 CDC26 CDC27 CDH1 CDK2 CDK4 CDK6 CDKN1 CDKN1A CDKN1B CDKN2 CDKN2A CDKN2B CDKN2C CDKN2D CDKN6 CEBPB CENP-27 CIP1 CXCL8 D0S1430E D17S978E E2EPF EHMT1 EHMT2 ERK1 ERK2 ERK5 EUHMTASE1 FOS FYR FZR FZR1 G0S7 G9A GLP H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HPX42B IFNB2 IGFBP7 IL1A IL1F1 IL6 IL8 ISPK1 JUN KIAA1242 KIAA1406 KIAA1876 KIP1 KMT1C KMT1D MAC25 MAPK1 MAPK3 MAPK7 MAPKAPK1A MAPKAPK1B MAPKAPK1C MDA6 MTS1 MTS2 NFKB1 NFKB3 NG36 PIC1 PRKM1 PRKM2 PRKM3 PRKM7 PSF RELA RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RSK1 RSK2 RSK3 SDI1 SFT STAT3 TCF5 TSG24 TSH2B UBA52 UBA80 UBB UBC UBC5A UBCEP1 UBCEP2 UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S VENTX VENTX2 WAF1 p27	Homo sapiens (human)
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	Vasopressin V2 receptor Vasopressin-neurophysin 2-copeptin	P01185 P30518	ADHR ARVP AVP AVPR2 DIR DIR3 V2R VP	Homo sapiens (human)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 GTPase HRas GTPase NRas Son of sevenless homolog 1	O15520 P01111 P01112 P05230 P08620 P09038 P10767 P11487 P31371 Q07889 Q9GZV9 Q9HCT0 Q9NP95	FGF1 FGF10 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF9 FGFA FGFB HRAS HRAS1 HST HST2 HSTF1 HSTF2 HYPF INT2 KS3 NRAS SOS1	Homo sapiens (human)
AMPK inhibits chREBP transcriptional activation activity	5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-2 5'-AMP-activated protein kinase subunit gamma-2 Adiponectin receptor protein 1 Adiponectin receptor protein 2 Adiponectin Carbohydrate-responsive element-binding protein Serine/threonine-protein kinase STK11	O43741 P54646 Q15831 Q15848 Q86V24 Q96A54 Q9NP71 Q9UGJ0	ACDC ACRP30 ADIPOQ ADIPOR1 ADIPOR2 AMPK AMPK2 APM1 BHLHD14 GBP28 LKB1 MIO MLXIPL PAQR1 PAQR2 PJS PRKAA2 PRKAB2 PRKAG2 STK11 TESBP1A WBSCR14	Homo sapiens (human)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	AT-rich interactive domain-containing protein 3A Cellular tumor antigen p53 Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B G1/S-specific cyclin-E1 G1/S-specific cyclin-E2 Poly(rC)-binding protein 4 Transcription factor E2F1 Transcription factor E2F7 Transcription factor E2F8 Zinc finger protein 385A	A0AVK6 O96020 P04637 P20248 P24864 P24941 P38936 P46527 P57723 P78396 Q01094 Q96AV8 Q96PM9 Q99856	ARID3A CAP20 CCN1 CCNA CCNA1 CCNA2 CCNE CCNE1 CCNE2 CDK2 CDKN1 CDKN1A CDKN1B CDKN2 CIP1 DRIL1 DRIL3 DRX E2F1 E2F7 E2F8 E2FBP1 HZF KIP1 MDA6 P53 PCBP4 PIC1 RBBP3 RZF SDI1 TP53 WAF1 ZNF385 ZNF385A p27	Homo sapiens (human)
Nectin/Necl trans heterodimerization	Cell adhesion molecule 1 Cell adhesion molecule 3 Nectin-1 Nectin-2 Nectin-3 Nectin-4 Poliovirus receptor	P15151 Q15223 Q8N126 Q92692 Q96NY8 Q9BY67 Q9NQS3	CADM1 CADM3 HVEB HVEC IGSF4 IGSF4A IGSF4B LNIR NECL1 NECL2 NECTIN1 NECTIN2 NECTIN3 NECTIN4 PRR1 PRR2 PRR3 PRR4 PVR PVRL1 PVRL2 PVRL3 PVRL4 PVS SYNCAM SYNCAM3 TSLC1 TSLL1	Homo sapiens (human)
Alternative complement activation	Complement C3 Complement factor B Complement factor D Granzyme M	P00746 P00751 P01024 P51124	BF BFD C3 CFB CFD CPAMD1 DF GZMM MET1 PFD	Homo sapiens (human)
AKT phosphorylates targets in the cytosol	Bcl2-associated agonist of cell death Caspase-9 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase makorin-1 Glycogen synthase kinase-3 alpha Glycogen synthase kinase-3 beta Inhibitor of nuclear factor kappa-B kinase subunit alpha Proline-rich AKT1 substrate 1 RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Tuberin	O15111 P31749 P31751 P38936 P46527 P49815 P49840 P49841 P55211 Q00987 Q92934 Q96B36 Q9UHC7 Q9Y243	AKT1 AKT1S1 AKT2 AKT3 BAD BBC6 BCL2L8 CAP20 CASP9 CDKN1 CDKN1A CDKN1B CHUK CIP1 GSK3A GSK3B IKKA KIP1 MCH6 MDA6 MDM2 MKRN1 PIC1 PKB PKBG PRAS40 RAC RNF61 SDI1 TCF16 TSC2 TSC4 WAF1 p27	Homo sapiens (human)
Sodium/Calcium exchangers	Calmodulin-1 Mitochondrial sodium/calcium exchanger protein Sodium/calcium exchanger 1 Sodium/calcium exchanger 2 Sodium/calcium exchanger 3 Sodium/potassium/calcium exchanger 1 Sodium/potassium/calcium exchanger 2 Sodium/potassium/calcium exchanger 3 Sodium/potassium/calcium exchanger 4 Sodium/potassium/calcium exchanger 5 Sorcin	O60721 P0DP23 P30626 P32418 P57103 Q6J4K2 Q71RS6 Q8NFF2 Q9HC58 Q9UI40 Q9UPR5	CALM CALM1 CAM CAM1 CNC JSX KIAA0702 KIAA1087 NCKX1 NCKX2 NCKX3 NCKX4 NCKX5 NCKX6 NCLX NCX1 NCX2 NCX3 SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SRI	Homo sapiens (human)
Cilium Assembly	Alpha-tubulin N-acetyltransferase 1 Histone deacetylase 6	Q5SQI0 Q9UBN7	ATAT1 C6orf134 HDAC6 KIAA0901 MEC17	Homo sapiens (human)
Defective BTD causes biotidinase deficiency	Biotinidase	P43251	BTD	Homo sapiens (human)

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