GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **751 - 775** of **2090** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol	Organism
GAB1 signalosome	Amphiregulin Epidermal growth factor receptor Epigen GRB2-associated-binding protein 1 Paxillin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Protransforming growth factor alpha Tyrosine-protein kinase CSK Tyrosine-protein phosphatase non-receptor type 11	O14944 P00533 P01133 P01135 P12931 P15514 P27986 P35070 P41240 P42336 P49023 Q06124 Q13480 Q6UW88 Q99075 Q9NWQ8	AREG AREGB BTC CBP CSK DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG GAB1 GRB1 HBEGF HEGFL HER1 PAG PAG1 PIK3CA PIK3R1 PTP2C PTPN11 PXN SDGF SHPTP2 SRC SRC1 TGFA	Homo sapiens (human)
SHC1 events in EGFR signaling	Amphiregulin Epidermal growth factor receptor Epigen GTPase HRas GTPase NRas Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha SHC-transforming protein 1 Son of sevenless homolog 1	O14944 P00533 P01111 P01112 P01133 P01135 P15514 P29353 P35070 Q07889 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 HRAS HRAS1 NRAS SDGF SHC SHC1 SHCA SOS1 TGFA	Homo sapiens (human)
GRB2 events in EGFR signaling	Amphiregulin Epidermal growth factor receptor Epigen GTPase HRas GTPase NRas Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha Son of sevenless homolog 1	O14944 P00533 P01111 P01112 P01133 P01135 P15514 P35070 Q07889 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 HRAS HRAS1 NRAS SDGF SOS1 TGFA	Homo sapiens (human)
Inhibition of Signaling by Overexpressed EGFR	Amphiregulin Epidermal growth factor receptor Epigen Pro-epidermal growth factor Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Protransforming growth factor alpha	O14944 P00533 P01133 P01135 P15514 P35070 Q6UW88 Q99075	AREG AREGB BTC DTR DTS EGF EGFR EPGN ERBB ERBB1 EREG HBEGF HEGFL HER1 SDGF TGFA	Homo sapiens (human)
GRB2:SOS provides linkage to MAPK signaling for Integrins	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibronectin Focal adhesion kinase 1 Integrin alpha-IIb Integrin beta-3 Proto-oncogene tyrosine-protein kinase Src Ras-related protein Rap-1A Ras-related protein Rap-1b Son of sevenless homolog 1 Talin-1 von Willebrand factor	P02671 P02675 P02679 P02751 P04275 P05106 P08514 P12931 P61224 P62834 Q05397 Q07889 Q7Z5R6 Q9Y490	APBB1IP F8VWF FAK FAK1 FGA FGB FGG FN FN1 GP2B GP3A ITGA2B ITGAB ITGB3 KIAA1027 KREV1 PREL1 PTK2 RAP1A RAP1B RARP1 RIAM SOS1 SRC SRC1 TLN TLN1 VWF	Homo sapiens (human)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Amyloid beta precursor protein binding family B member 1 BRCA1-A complex subunit Abraxas 1 BRCA1-A complex subunit RAP80 BRCA1-associated RING domain protein 1 BRISC and BRCA1-A complex member 1 BRISC and BRCA1-A complex member 2 Breast cancer type 1 susceptibility protein Cellular tumor antigen p53 DNA repair protein RAD50 Double-strand break repair protein MRE11 E3 SUMO-protein ligase PIAS4 E3 ubiquitin-protein ligase HERC2 E3 ubiquitin-protein ligase RNF168 E3 ubiquitin-protein ligase RNF8 Eyes absent homolog 1 Eyes absent homolog 2 Eyes absent homolog 3 Eyes absent homolog 4 Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1t Histone H4 Histone acetyltransferase KAT5 Histone-lysine N-methyltransferase NSD2 Lys-63-specific deubiquitinase BRCC36 Lysine-specific demethylase 4A Lysine-specific demethylase 4B Mediator of DNA damage checkpoint protein 1 Mitogen-activated protein kinase 8 Nibrin Polyubiquitin-B Polyubiquitin-C SUMO-conjugating enzyme UBC9 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Serine-protein kinase ATM Serine/threonine-protein kinase Chk2 Serine/threonine-protein phosphatase 5 Small ubiquitin-related modifier 1 TP53-binding protein 1 Tyrosine-protein kinase ABL1 Tyrosine-protein kinase BAZ1B UBX domain-containing protein 1 Ubiquitin carboxyl-terminal hydrolase BAP1 Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 2 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00167 O00213 O60264 O60814 O60934 O75164 O76064 O94953 O95677 O95714 O96017 O96028 P00519 P04637 P06899 P0CG47 P0CG48 P16104 P23527 P33778 P38398 P45983 P46736 P49959 P53041 P57053 P58876 P61088 P62805 P62807 P62979 P62987 P63165 P63279 Q04323 Q12888 Q13315 Q14676 Q15819 Q16695 Q16778 Q6UWZ7 Q8IYW5 Q8N257 Q8N2W9 Q92560 Q92878 Q92993 Q93079 Q96A08 Q96RL1 Q99502 Q99504 Q99728 Q99877 Q99879 Q99880 Q9NWV8 Q9NXR7 Q9UIG0	ABL ABL1 ABRA1 ABRAXAS1 APBB1 ATM BABAM1 BABAM2 BAP1 BARD1 BAZ1B BLU BRCA1 BRCC3 BRCC36 BRCC45 BRE C19orf62 C6.1A CCDC98 CDS1 CHEK2 CHK2 CXorf53 EAB1 EYA1 EYA2 EYA3 EYA4 FAM175A FE65 H2AFX H2AX H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-4 H3FT H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HERC2 HIRIP1 HIRIP2 HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2BE HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST3H3 HIST4H4 HNGS1 HTATIP JHDM3A JHDM3B JMJD2 JMJD2A JMJD2B JNK1 JTK7 KAT5 KDM4A KDM4B KIAA0170 KIAA0272 KIAA0646 KIAA0677 KIAA0876 KIAA1090 MAPK8 MDC1 MERIT40 MMS2 MMSET MRE11 MRE11A NBA1 NBN NBS NBS1 NFBD1 NSD2 P53 P95 PIAS4 PIASG PPP5 PPP5C PRKM8 RAD50 RAD53 RAP80 RIR RNF168 RNF53 RNF8 RPS27A RXRIP110 SAKS1 SAPK1 SAPK1C SMARCA5 SMT3C SMT3H3 SNF2H SUMO1 TIP60 TP53 TP53BP1 TRX5 TSH2B UBA52 UBA80 UBB UBC UBC9 UBCE9 UBCEP1 UBCEP2 UBE2I UBE2N UBE2V2 UBL1 UBXN1 UEV2 UIMC1 WBSC10 WBSCR10 WBSCR9 WCRF135 WHSC1 WSTF	Homo sapiens (human)
Neurexins and neuroligins	Amyloid-beta A4 precursor protein-binding family A member 1 Amyloid-beta A4 precursor protein-binding family A member 2 Amyloid-beta A4 precursor protein-binding family A member 3 Band 4.1-like protein 1 Band 4.1-like protein 2 Band 4.1-like protein 3 Band 4.1-like protein 5 Brain-enriched guanylate kinase-associated protein Disks large homolog 2 Disks large homolog 3 Disks large homolog 4 Disks large-associated protein 1 Disks large-associated protein 2 Disks large-associated protein 3 Disks large-associated protein 4 Drebrin-like protein Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2A Glutamate receptor ionotropic, NMDA 2B Glutamate receptor ionotropic, NMDA 2C Glutamate receptor ionotropic, NMDA 2D Homer protein homolog 1 Homer protein homolog 2 Homer protein homolog 3 Leucine-rich repeat transmembrane neuronal protein 1 Leucine-rich repeat transmembrane neuronal protein 2 Leucine-rich repeat transmembrane neuronal protein 3 Leucine-rich repeat transmembrane neuronal protein 4 Metabotropic glutamate receptor 1 Metabotropic glutamate receptor 5 Neurexin-1-beta Neurexin-1 Neurexin-2-beta Neurexin-2 Neurexin-3-beta Neurexin-3 Neuroligin-1 Neuroligin-2 Neuroligin-3 Neuroligin-4, X-linked Neuroligin-4, Y-linked PDZ and LIM domain protein 5 Peripheral plasma membrane protein CASK Protein 4.1 Protein lin-7 homolog A Protein lin-7 homolog B Protein lin-7 homolog C SH3 and multiple ankyrin repeat domains protein 1 SH3 and multiple ankyrin repeat domains protein 2 SH3 and multiple ankyrin repeat domains protein 3 Sharpin Signal-induced proliferation-associated 1-like protein 1 Synaptotagmin-10 Synaptotagmin-12 Synaptotagmin-1 Synaptotagmin-2 Synaptotagmin-7 Synaptotagmin-9 Syntaxin-1A Syntaxin-binding protein 1	O14490 O14910 O14936 O15399 O43166 O43300 O43491 O43581 O95886 O96018 P11171 P21579 P41594 P58400 P58401 P61764 P78352 Q02410 Q05586 Q12879 Q13224 Q13255 Q14957 Q15700 Q16623 Q6XYQ8 Q86SS6 Q86UE6 Q86VH4 Q86VH5 Q86YM7 Q8IV01 Q8N0W4 Q8N2Q7 Q8N9I0 Q8NFZ3 Q8NFZ4 Q92796 Q96HC4 Q99767 Q9BUH8 Q9BYB0 Q9H0F6 Q9H4G0 Q9HAP6 Q9HCM4 Q9HDB5 Q9NSB8 Q9NSC5 Q9NUP9 Q9NZ94 Q9P1A6 Q9P2S2 Q9UJU6 Q9ULB1 Q9UPX8 Q9Y2H0 Q9Y2J2 Q9Y4C0 Q9Y566	APBA1 APBA2 APBA3 BEGAIN C14orf60 C8orf68 CASK CMAP CORTBP1 DAL1 DAP1 DAP2 DAP3 DAP4 DBNL DLG2 DLG3 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 E41P E6TP1 ENH EPB41 EPB41L1 EPB41L2 EPB41L3 EPB41L5 ERICH1-AS1 GKAP GPRC1A GPRC1E GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRM1 GRM5 GluN2D HOMER1 HOMER2 HOMER3 KIAA0338 KIAA0416 KIAA0440 KIAA0578 KIAA0743 KIAA0921 KIAA0951 KIAA0964 KIAA0987 KIAA1022 KIAA1070 KIAA1232 KIAA1260 KIAA1366 KIAA1446 KIAA1480 KIAA1548 KIAA1650 LIN2 LIN7A LIN7B LIN7C LRRN2 LRRTM1 LRRTM2 LRRTM3 LRRTM4 MALS1 MALS2 MALS3 MGLUR1 MGLUR5 MINT1 MINT2 MINT3 NL3 NLGN1 NLGN2 NLGN3 NLGN4 NLGN4X NLGN4Y NMDAR1 NMDAR2A NMDAR2B NMDAR2C NMDAR2D NRXN1 NRXN2 NRXN3 PCANAP7 PDLIM5 PROSAP1 PROSAP2 PSAP2 PSD95 SAPAP4 SH3P7 SHANK1 SHANK2 SHANK3 SHARPIN SIPA1L1 SIPL1 STX1 STX1A STXBP1 SVP65 SYN47 SYT SYT1 SYT10 SYT12 SYT2 SYT7 SYT9 UNC18A VELI1 VELI2 VELI3 X11 X11L X11L2	Homo sapiens (human)
Dopamine Neurotransmitter Release Cycle	Amyloid-beta A4 precursor protein-binding family A member 1 Complexin-1 Liprin-alpha-1 Liprin-alpha-2 Liprin-alpha-3 Liprin-alpha-4 Peripheral plasma membrane protein CASK Peripheral-type benzodiazepine receptor-associated protein 1 Protein lin-7 homolog A Protein lin-7 homolog B Protein lin-7 homolog C Protein unc-13 homolog B Ras-related protein Rab-3A Regulating synaptic membrane exocytosis protein 1 Synapsin-1 Synapsin-2 Synapsin-3 Synaptic vesicular amine transporter Synaptosomal-associated protein 25 Synaptotagmin-1 Syntaxin-1A Vesicle-associated membrane protein 2	O14795 O14810 O14910 O14936 O14994 O75145 O75334 O75335 O95153 P17600 P20336 P21579 P60880 P63027 Q02410 Q05940 Q13136 Q16623 Q86UR5 Q92777 Q9HAP6 Q9NUP9	APBA1 BZRAP1 CASK CPLX1 KIAA0340 KIAA0612 KIAA0654 KIAA0897 LIN2 LIN7A LIN7B LIN7C LIP1 MALS1 MALS2 MALS3 MINT1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RAB3IP2 RBP1 RIM1 RIMBP1 RIMS1 SLC18A2 SNAP SNAP25 STX1 STX1A SVMT SVP65 SYB2 SYN1 SYN2 SYN3 SYT SYT1 TSPOAP1 UNC13 UNC13B VAMP2 VELI1 VELI2 VELI3 VMAT2 X11	Homo sapiens (human)
Formyl peptide receptors bind formyl peptides and many other ligands	Amyloid-beta precursor protein Annexin A1 Heme-binding protein 1 Humanin N-formyl peptide receptor 2 N-formyl peptide receptor 3 Serum amyloid A-1 protein fMet-Leu-Phe receptor	P04083 P05067 P0DJI8 P21462 P25089 P25090 Q8IVG9 Q9NRV9	A4 AD1 ANX1 ANXA1 APP FPR1 FPR2 FPR3 FPRH1 FPRL1 FPRL2 HBP HEBP1 HN LPC1 LXA4R MT-RNR2 SAA1	Homo sapiens (human)
Cytosolic iron-sulfur cluster assembly	Anamorsin Cytosolic Fe-S cluster assembly factor NUBP1 Cytosolic Fe-S cluster assembly factor NUBP2 Cytosolic iron-sulfur assembly component 2B Cytosolic iron-sulfur assembly component 3 DNA polymerase delta catalytic subunit Fanconi anemia group J protein General transcription and DNA repair factor IIH helicase subunit XPD Iron-sulfur clusters transporter ABCB7, mitochondrial MMS19 nucleotide excision repair protein homolog NADPH-dependent diflavin oxidoreductase 1 Probable cytosolic iron-sulfur protein assembly protein CIAO1 Regulator of telomere elongation helicase 1	O75027 O76071 P18074 P28340 P53384 Q6FI81 Q96T76 Q9BX63 Q9H6Q4 Q9NZ71 Q9UHB4 Q9Y3D0 Q9Y5Y2	ABC7 ABCB7 BACH1 BRIP1 C20orf41 CIA1 CIAB CIAO1 CIAO2B CIAO3 CIAPIN1 ERCC2 FAM96B FANCJ KIAA1088 MIP18 MMS19 MMS19L NARFL NBP NBP1 NDOR1 NHL NR1 NUBP1 NUBP2 POLD POLD1 PRN RTEL1 WDR39 XPD XPDC	Homo sapiens (human)
Transcriptional Regulation by VENTX	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 CCAAT/enhancer-binding protein beta Catenin beta-1 Cell division cycle protein 16 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cellular tumor antigen p53 Cyclin-dependent kinase inhibitor 2A Fizzy-related protein homolog G1/S-specific cyclin-D1 Helicase MOV-10 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Homeobox protein VENTX Interleukin-6 Lymphoid enhancer-binding factor 1 Macrophage colony-stimulating factor 1 receptor Nuclear factor NF-kappa-B p105 subunit Protein argonaute-1 Protein argonaute-3 Protein argonaute-4 Transcription factor 7-like 2 Transcription factor p65 Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 O95231 P04637 P05231 P07333 P17676 P19838 P24385 P30260 P35222 P42771 P51668 P51965 P60006 Q04206 Q13042 Q16763 Q8NDV7 Q8NHZ8 Q96DE5 Q96KQ7 Q9H1A4 Q9H9B1 Q9H9G7 Q9HCE1 Q9HCJ0 Q9HCK5 Q9NQB0 Q9NYG5 Q9UJU2 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UL18 Q9UM11 Q9UM13 Q9UPQ9	AGO1 AGO3 AGO4 ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 BAT8 BCL1 C10orf104 C11orf51 C6orf30 C9orf17 CAGH26 CCND1 CDC16 CDC23 CDC26 CDC27 CDH1 CDKN2 CDKN2A CEBPB CENP-27 CSF1R CTNNB CTNNB1 D0S1430E D17S978E E2EPF EHMT1 EHMT2 EIF2C1 EIF2C3 EIF2C4 EUHMTASE1 FMS FYR FZR FZR1 G9A GLP HPX42B IFNB2 IL6 KIAA1093 KIAA1242 KIAA1406 KIAA1460 KIAA1567 KIAA1582 KIAA1631 KIAA1876 KMT1C KMT1D LEF1 MOV10 MTS1 NFKB1 NFKB3 NG36 P53 PRAD1 RELA SFT TCF4 TCF5 TCF7L2 TNRC6 TNRC6A TNRC6B TNRC6C TP53 TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S VENTX VENTX2	Homo sapiens (human)
Senescence-Associated Secretory Phenotype (SASP)	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 CCAAT/enhancer-binding protein beta Cell division cycle protein 16 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 inhibitor C Cyclin-dependent kinase 4 inhibitor D Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor 2A Fizzy-related protein homolog Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-lysine N-methyltransferase EHMT1 Histone-lysine N-methyltransferase EHMT2 Homeobox protein VENTX Insulin-like growth factor-binding protein 7 Interleukin-1 alpha Interleukin-6 Interleukin-8 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 7 Nuclear factor NF-kappa-B p105 subunit Polyubiquitin-B Polyubiquitin-C Protein c-Fos Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-2 Ribosomal protein S6 kinase alpha-3 Signal transducer and activator of transcription 3 Transcription factor Jun Transcription factor p65 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00762 O60814 O95231 P01100 P01583 P04908 P05231 P05412 P06899 P0C5Y9 P0CG47 P0CG48 P10145 P11802 P16104 P17676 P19838 P20248 P20671 P23527 P24941 P27361 P28482 P30260 P33778 P38936 P40763 P42771 P42772 P42773 P46527 P51668 P51812 P51965 P55273 P57053 P58876 P60006 P62805 P62807 P62979 P62987 P68431 P78396 P84243 Q00534 Q04206 Q13042 Q13164 Q15349 Q15418 Q16270 Q16763 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q8NHZ8 Q93077 Q93079 Q96A08 Q96DE5 Q96KQ7 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9H1A4 Q9H9B1 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM11 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 APRF BAT8 BMK1 C10orf104 C11orf51 C6orf30 C9orf17 CAP20 CCN1 CCNA CCNA1 CCNA2 CDC16 CDC23 CDC26 CDC27 CDH1 CDK2 CDK4 CDK6 CDKN1 CDKN1A CDKN1B CDKN2 CDKN2A CDKN2B CDKN2C CDKN2D CDKN6 CEBPB CENP-27 CIP1 CXCL8 D0S1430E D17S978E E2EPF EHMT1 EHMT2 ERK1 ERK2 ERK5 EUHMTASE1 FOS FYR FZR FZR1 G0S7 G9A GLP H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HPX42B IFNB2 IGFBP7 IL1A IL1F1 IL6 IL8 ISPK1 JUN KIAA1242 KIAA1406 KIAA1876 KIP1 KMT1C KMT1D MAC25 MAPK1 MAPK3 MAPK7 MAPKAPK1A MAPKAPK1B MAPKAPK1C MDA6 MTS1 MTS2 NFKB1 NFKB3 NG36 PIC1 PRKM1 PRKM2 PRKM3 PRKM7 PSF RELA RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RSK1 RSK2 RSK3 SDI1 SFT STAT3 TCF5 TSG24 TSH2B UBA52 UBA80 UBB UBC UBC5A UBCEP1 UBCEP2 UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S VENTX VENTX2 WAF1 p27	Homo sapiens (human)
Regulation of APC/C activators between G1/S and early anaphase	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cyclin-A1 Cyclin-A2 Cyclin-dependent kinase 1 Cyclin-dependent kinase 2 F-box only protein 5 Fizzy-related protein homolog G2/mitotic-specific cyclin-B1 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 P06493 P14635 P20248 P24941 P30260 P51668 P51965 P60006 P78396 Q12834 Q13042 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UKT4 Q9UM11 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 C10orf104 C11orf51 C9orf17 CCN1 CCNA CCNA1 CCNA2 CCNB CCNB1 CDC16 CDC2 CDC20 CDC23 CDC26 CDC27 CDC28A CDH1 CDK1 CDK2 CDKN1 CDKN2 CENP-27 D0S1430E D17S978E E2EPF EMI1 FBX5 FBXO5 FYR FZR FZR1 KIAA1242 KIAA1406 P34CDC2 SFT TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
APC/C:Cdc20 mediated degradation of Cyclin B	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Polyubiquitin-B Polyubiquitin-C Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00762 P06493 P0CG47 P0CG48 P14635 P30260 P51668 P51965 P60006 P62979 P62987 Q12834 Q13042 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 C10orf104 C11orf51 C9orf17 CCNB CCNB1 CDC16 CDC2 CDC20 CDC23 CDC26 CDC27 CDC28A CDK1 CDKN1 CENP-27 D0S1430E D17S978E E2EPF KIAA1406 P34CDC2 RPS27A SFT TSG24 UBA52 UBA80 UBB UBC UBC5A UBCEP1 UBCEP2 UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Dual specificity protein phosphatase CDC14A Fizzy-related protein homolog Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 P30260 P51668 P51965 P60006 Q12834 Q13042 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM11 Q9UM13 Q9UNH5	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 C10orf104 C11orf51 C9orf17 CDC14A CDC16 CDC20 CDC23 CDC26 CDC27 CDH1 CENP-27 D0S1430E D17S978E E2EPF FYR FZR FZR1 KIAA1242 KIAA1406 SFT TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
APC-Cdc20 mediated degradation of Nek2A	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic spindle assembly checkpoint protein MAD2A Polyubiquitin-B Polyubiquitin-C Serine/threonine-protein kinase Nek2 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00762 O43684 O60566 P0CG47 P0CG48 P30260 P51668 P51955 P51965 P60006 P62979 P62987 Q12834 Q13042 Q13257 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 BUB1B BUB3 BUBR1 C10orf104 C11orf51 C9orf17 CDC16 CDC20 CDC23 CDC26 CDC27 CENP-27 D0S1430E D17S978E E2EPF KIAA1406 MAD2 MAD2L1 MAD3L NEK2 NEK2A NLK1 RPS27A SFT SSK1 TSG24 UBA52 UBA80 UBB UBC UBC5A UBCEP1 UBCEP2 UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
APC/C:Cdc20 mediated degradation of mitotic proteins	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic spindle assembly checkpoint protein MAD2A Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 O43684 O60566 P30260 P51668 P51965 P60006 Q12834 Q13042 Q13257 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 BUB1B BUB3 BUBR1 C10orf104 C11orf51 C9orf17 CDC16 CDC20 CDC23 CDC26 CDC27 CENP-27 D0S1430E D17S978E E2EPF KIAA1406 MAD2 MAD2L1 MAD3L SFT SSK1 TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
Inactivation of APC/C via direct inhibition of the APC/C complex	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 20 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Mitotic checkpoint protein BUB3 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Mitotic spindle assembly checkpoint protein MAD2A Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 O43684 O60566 P30260 P51668 P51965 P60006 Q12834 Q13042 Q13257 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 BUB1B BUB3 BUBR1 C10orf104 C11orf51 C9orf17 CDC16 CDC20 CDC23 CDC26 CDC27 CENP-27 D0S1430E D17S978E E2EPF KIAA1406 MAD2 MAD2L1 MAD3L SFT SSK1 TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
Phosphorylation of the APC/C	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Serine/threonine-protein kinase PLK1 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 P06493 P14635 P30260 P51668 P51965 P53350 P60006 Q13042 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 C10orf104 C11orf51 C9orf17 CCNB CCNB1 CDC16 CDC2 CDC23 CDC26 CDC27 CDC28A CDK1 CDKN1 CENP-27 D0S1430E D17S978E E2EPF KIAA1406 P34CDC2 PLK PLK1 SFT TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
Aberrant regulation of mitotic exit in cancer due to RB1 defects	Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 15 Anaphase-promoting complex subunit 16 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Anaphase-promoting complex subunit 4 Anaphase-promoting complex subunit 5 Anaphase-promoting complex subunit 7 Anaphase-promoting complex subunit CDC26 Cell division cycle protein 16 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Fizzy-related protein homolog Retinoblastoma-associated protein S-phase kinase-associated protein 2 Ubiquitin-conjugating enzyme E2 C Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 E1 Ubiquitin-conjugating enzyme E2 S	O00762 P06400 P30260 P51668 P51965 P60006 Q13042 Q13309 Q16763 Q8NHZ8 Q96DE5 Q9H1A4 Q9NYG5 Q9UJX2 Q9UJX3 Q9UJX4 Q9UJX5 Q9UJX6 Q9UM11 Q9UM13	ANAPC1 ANAPC10 ANAPC11 ANAPC12 ANAPC15 ANAPC16 ANAPC2 ANAPC3 ANAPC4 ANAPC5 ANAPC6 ANAPC7 ANAPC8 APC10 APC2 APC4 APC5 APC7 C10orf104 C11orf51 C9orf17 CDC16 CDC23 CDC26 CDC27 CDH1 CENP-27 D0S1430E D17S978E E2EPF FBXL1 FYR FZR FZR1 KIAA1242 KIAA1406 RB1 SFT SKP2 TSG24 UBC5A UBCH10 UBCH5 UBCH5A UBCH6 UBE2C UBE2D1 UBE2E1 UBE2S	Homo sapiens (human)
Nuclear Receptor transcription pathway	Androgen receptor COUP transcription factor 1 Estrogen receptor beta Estrogen receptor Estrogen-related receptor gamma Hepatocyte nuclear factor 4-alpha Hepatocyte nuclear factor 4-gamma Mediator of RNA polymerase II transcription subunit 1 Nuclear receptor 2C2-associated protein Nuclear receptor ROR-alpha Nuclear receptor ROR-beta Nuclear receptor ROR-gamma Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Nuclear receptor subfamily 0 group B member 2 Nuclear receptor subfamily 1 group D member 1 Nuclear receptor subfamily 1 group D member 2 Nuclear receptor subfamily 2 group C member 1 Nuclear receptor subfamily 2 group C member 2 Nuclear receptor subfamily 2 group E member 1 Nuclear receptor subfamily 2 group F member 6 Nuclear receptor subfamily 4 group A member 2 Nuclear receptor subfamily 4immunitygroup A member 1 Nuclear receptor-binding protein Oxysterols receptor LXR-beta Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor delta Peroxisome proliferator-activated receptor gamma Progesterone receptor Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta Retinoic acid receptor RXR-gamma Retinoic acid receptor alpha Retinoic acid receptor beta Retinoic acid receptor gamma Steroid hormone receptor ERR1 Steroid hormone receptor ERR2 Steroidogenic factor 1 Thyroid hormone receptor alpha Thyroid hormone receptor beta Vitamin D3 receptor	O75376 O95718 P03372 P06401 P10275 P10276 P10588 P10589 P10826 P10827 P10828 P11473 P11474 P13056 P13631 P19793 P20393 P22736 P28702 P35398 P37231 P41235 P43354 P48443 P49116 P51449 P55055 P62508 Q03181 Q07869 Q13285 Q14541 Q14995 Q15466 Q15648 Q86WQ0 Q92731 Q92753 Q9UHY1 Q9Y466 Q9Y618	AD4BP AR ARC205 BCON3 CRSP1 CRSP200 CTG26 DHTR DRIP205 DRIP230 EAR1 EAR2 EAR3 EAR7 ERBA1 ERBA2 ERBAL2 ERBAL3 ERR1 ERR3 ERRB2 ERRG2 ESR ESR1 ESR2 ESRL1 ESRL2 ESRRA ESRRB ESRRG ESTRB FTZF1 GFRP1 HAP HMR HNF4 HNF4A HNF4G HREV KIAA0832 KIAA1047 LXRB MED1 NAK1 NCOR1 NCOR2 NER NOT NR0B2 NR1A1 NR1A2 NR1B1 NR1B2 NR1B3 NR1C1 NR1C2 NR1C3 NR1D1 NR1D2 NR1F1 NR1F2 NR1F3 NR1H2 NR1I1 NR2A1 NR2A2 NR2B1 NR2B2 NR2B3 NR2C1 NR2C2 NR2C2AP NR2E1 NR2F1 NR2F6 NR3A1 NR3A2 NR3B1 NR3B2 NR3B3 NR3C3 NR3C4 NR4A1 NR4A2 NR5A1 NRBP NRBP1 NURR1 PBP PGR PPAR PPARA PPARB PPARBP PPARD PPARG PPARGBP RARA RARB RARG RB18A RORA RORB RORC RORG RXRA RXRB RXRG RZRA RZRB RZRG SF1 SHP TAK1 TCF14 TFCOUP1 THR1 THRA THRA1 THRA2 THRAL THRB TINUR TLX TR2 TR4 TRA16 TRAP220 TRIP2 UNR VDR	Homo sapiens (human)
RUNX2 regulates osteoblast differentiation	Androgen receptor Collagen alpha-1(I) chain Core-binding factor subunit beta DNA-binding protein SATB2 Hairy/enhancer-of-split related with YRPW motif protein 1 Hairy/enhancer-of-split related with YRPW motif protein 2 Histone deacetylase 3 Histone deacetylase 6 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Osteocalcin Proto-oncogene tyrosine-protein kinase Src Retinoblastoma-associated protein Transcription factor HES-1 Transcription factor Maf Transcription factor Sp7 Transcriptional activator GLI3 Transcriptional coactivator YAP1 Tyrosine-protein kinase ABL1 Tyrosine-protein kinase Yes Unique cartilage matrix-associated protein WW domain-containing transcription regulator protein 1 Zinc finger protein 521	O15379 O75444 P00519 P02452 P02818 P06400 P07947 P10071 P10275 P12931 P27361 P28482 P46937 Q13951 Q14469 Q8TDD2 Q8WVF2 Q96K83 Q9GZV5 Q9UBN7 Q9UBP5 Q9UPW6 Q9Y5J3	ABL ABL1 AR BGLAP BHLHB31 BHLHB32 BHLHB39 C10orf49 CBFB CHF1 CHF2 COL1A1 DHTR EHZF ERK1 ERK2 GLI3 GRL HDAC3 HDAC6 HERP HERP1 HERP2 HES1 HESR1 HEY1 HEY2 HL HRT1 HRT2 HRY JTK7 KIAA0901 KIAA1034 LIP3 MAF MAPK1 MAPK3 NR3C4 OSX PRKM1 PRKM2 PRKM3 RB1 SATB2 SP7 SRC SRC1 TAZ UCMA WWTR1 YAP1 YAP65 YES YES1 ZNF521	Homo sapiens (human)
SUMOylation of intracellular receptors	Androgen receptor E3 SUMO-protein ligase PIAS1 E3 SUMO-protein ligase PIAS3 E3 SUMO-protein ligase PIAS4 Estrogen receptor Glucocorticoid receptor Histone deacetylase 4 Mineralocorticoid receptor Nuclear receptor ROR-alpha Nuclear receptor subfamily 2 group C member 1 Nuclear receptor subfamily 4 group A member 2 Oxysterols receptor LXR-beta Peroxisome proliferator-activated receptor alpha Peroxisome proliferator-activated receptor gamma Progesterone receptor Retinoic acid receptor RXR-alpha Retinoic acid receptor alpha SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 2 Small ubiquitin-related modifier 3 Steroidogenic factor 1 Thyroid hormone receptor beta Vitamin D3 receptor	O75925 P03372 P04150 P06401 P08235 P10275 P10276 P10828 P11473 P13056 P19793 P35398 P37231 P43354 P55055 P55854 P56524 P61956 P63165 P63279 Q07869 Q13285 Q8N2W9 Q9Y6X2	AD4BP AR DDXBP1 DHTR ERBA2 ESR ESR1 FTZF1 GRL HDAC4 KIAA0288 LXRB MCR MLR NER NOT NR1A2 NR1B1 NR1C1 NR1C3 NR1F1 NR1H2 NR1I1 NR2B1 NR2C1 NR3A1 NR3C1 NR3C2 NR3C3 NR3C4 NR4A2 NR5A1 NURR1 PGR PIAS1 PIAS3 PIAS4 PIASG PPAR PPARA PPARG RARA RORA RXRA RZRA SF1 SMT3A SMT3B SMT3C SMT3H1 SMT3H2 SMT3H3 SUMO1 SUMO2 SUMO3 THR1 THRB TINUR TR2 UBC9 UBCE9 UBE2I UBL1 UNR VDR	Homo sapiens (human)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Androgen receptor Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Kallikrein-2 Lysine-specific demethylase 4C Lysine-specific histone demethylase 1A Nuclear receptor coactivator 2 Prostate-specific antigen Serine/threonine-protein kinase N1	O60341 O60814 P04908 P06899 P07288 P0C5Y9 P10275 P16104 P20151 P20671 P23527 P33778 P57053 P58876 P62805 P62807 P68431 P84243 Q15596 Q16512 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8N257 Q93077 Q93079 Q96A08 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9H3R0	AOF2 APS AR BHLHE75 DHTR GASC1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 JHDM3C JMJD2C KDM1 KDM1A KDM4C KIAA0601 KIAA0780 KLK2 KLK3 LSD1 NCOA2 NR3C4 PAK1 PKN PKN1 PRK1 PRKCL1 SRC2 TIF2 TSH2B	Homo sapiens (human)
NOD1/2 Signaling Pathway	Angio-associated migratory cell protein Baculoviral IAP repeat-containing protein 2 Baculoviral IAP repeat-containing protein 3 Caspase recruitment domain-containing protein 9 Caspase-1 Caspase-2 Caspase-4 Caspase-8 Caspase-9 Dual specificity mitogen-activated protein kinase kinase 6 E3 ubiquitin-protein ligase Itchy homolog Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 13 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Nucleoprotein Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TNF receptor-associated factor 6 Tumor necrosis factor alpha-induced protein 3 Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin-conjugating enzyme E2 N Ubiquitin-conjugating enzyme E2 variant 1	O14920 O15111 O15264 O43187 O43318 O43353 P0DTC9 P21580 P29466 P42575 P49662 P51617 P52564 P53778 P55211 P61088 Q13404 Q13489 Q13490 Q13685 Q14790 Q15750 Q15759 Q16539 Q8N5C8 Q96J02 Q9H257 Q9HC29 Q9NQC7 Q9NYJ8 Q9Y239 Q9Y4K3 Q9Y6K9	AAMP API1 API2 BIRC2 BIRC3 BLU CARD15 CARD4 CARD9 CARDIAK CASP1 CASP2 CASP4 CASP8 CASP9 CHUK CROC1 CSBP CSBP1 CSBP2 CSPB1 CYLD CYLD1 ERK6 FIP3 ICH1 ICH2 IKBKB IKBKG IKKA IKKB IL1BC IL1BCE IRAK IRAK1 IRAK2 ITCH KIAA0733 KIAA0849 MAP2K6 MAP3K7 MAP3K7IP1 MAP3K7IP2 MAP3K7IP3 MAPK11 MAPK12 MAPK13 MAPK14 MCH5 MCH6 MEK6 MIHB MIHC MKK6 MXI2 N NEDD2 NEMO NOD1 NOD2 OTUD7C PRKM11 PRKM13 PRKMK6 RICK RIP2 RIPK2 RNF48 RNF49 RNF85 SAPK2 SAPK2A SAPK2B SAPK3 SAPK4 SKK3 TAB1 TAB2 TAB3 TAK1 TCF16 TNFAIP3 TRAF6 UBE2N UBE2V UBE2V1 UEV1	Homo sapiens (human)

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