RAS signaling downstream of NF1 loss-of-function variants
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- EVE-3
- HRAS
- HRAS1
- NF1
- NRAS
- SPRED1
- SPRED2
- SPRED3
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Homo sapiens (human)
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PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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- ARH12
- ARHA
- ARHGAP35
- BCAR1
- BRK
- CAS
- CASS1
- CED12A
- CRK
- CRKAS
- DOCK1
- ELMO1
- ELMO2
- GAP
- GRF1
- GRLF1
- HRAS
- HRAS1
- KIAA0281
- KIAA1722
- KIAA1834
- NRAS
- P190A
- PTK6
- PXN
- RAC1
- RASA
- RASA1
- RHO12
- RHOA
- TC25
- p190ARHOGAP
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Homo sapiens (human)
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Activated NTRK3 signals through RAS
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- HRAS
- HRAS1
- NRAS
- NTF3
- NTRK3
- SOS1
- TRKC
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Homo sapiens (human)
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Signaling by FGFR4 in disease
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- FGFR4
- FRS2
- GAB1
- GRB1
- HRAS
- HRAS1
- JTK2
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SOS1
- TKF
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Homo sapiens (human)
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Signaling by FLT3 fusion proteins
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- CAP20
- CD245
- CDKN1
- CDKN1A
- CEV14
- CIP1
- ETV6
- FIM
- GAB2
- GOLGB1
- GRB1
- HRAS
- HRAS1
- KIAA0216
- KIAA0571
- MDA6
- MYO18A
- MYSPDZ
- NOX4
- NRAS
- PIC1
- PIK3CA
- PIK3R1
- PIM1
- RAMP
- RENOX
- SDI1
- SOS1
- SPTB2
- SPTBN1
- STAT5
- STAT5A
- STAT5B
- TEL
- TEL1
- TIAF1
- TRIP11
- WAF1
- ZMYM2
- ZNF198
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Homo sapiens (human)
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MET activates RAS signaling
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- HGF
- HPTA
- HRAS
- HRAS1
- KIAA1359
- KIAA1464
- MET
- MUC20
- NRAS
- RANBP10
- RANBP9
- RANBPM
- SOS1
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Homo sapiens (human)
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Constitutive Signaling by Overexpressed ERBB2
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- CDC37
- CDC37A
- ERBB2
- ERBB2IP
- ERBIN
- HER2
- HRAS
- HRAS1
- HSP90A
- HSP90AA1
- HSPC1
- HSPCA
- KIAA1225
- LAP2
- MLN19
- NEU
- NGL
- NRAS
- PTPN12
- SHC
- SHC1
- SHCA
- SOS1
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Homo sapiens (human)
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Negative regulation of MAPK pathway
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- ARAF
- ARAF1
- BRAF
- BRAF1
- BRAP
- C11orf81
- CL100
- CTAK1
- DUSP1
- DUSP10
- DUSP16
- DUSP2
- DUSP4
- DUSP5
- DUSP6
- DUSP7
- DUSP8
- DUSP9
- EMK2
- ERK1
- ERK2
- ERK6
- HRAS
- HRAS1
- KIAA0044
- KIAA1700
- KSR
- KSR1
- MAPK1
- MAPK12
- MAPK3
- MARK3
- MKP1
- MKP2
- MKP3
- MKP4
- MKP5
- MKP7
- NRAS
- PAC1
- PAQR3
- PBP
- PEBP
- PEBP1
- PKS
- PKS2
- PPP2CA
- PPP2CB
- PPP2R1A
- PPP2R1B
- PPP2R5A
- PPP2R5B
- PPP2R5C
- PPP2R5D
- PPP2R5E
- PPP5
- PPP5C
- PRKM1
- PRKM2
- PRKM3
- PTPH1
- PTPN10
- PTPN3
- PTPN7
- PYST1
- PYST2
- RAF
- RAF1
- RAFB1
- RNF52
- RPS27A
- SAPK3
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- VH1
- VH2
- VH3
- VH5
- YWHAB
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Homo sapiens (human)
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Signaling by high-kinase activity BRAF mutants
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- APBB1IP
- ARAF
- ARAF1
- ARB2
- ARR1
- ARR2
- ARRB1
- ARRB2
- BRAF
- BRAF1
- CNK1
- CNK2
- CNKSR1
- CNKSR2
- CSK
- CTAK1
- EMK2
- ERK1
- ERK2
- F8VWF
- FGA
- FGB
- FGG
- FN
- FN1
- GP2B
- GP3A
- HRAS
- HRAS1
- IQGAP1
- ITGA2B
- ITGAB
- ITGB3
- KIAA0051
- KIAA0902
- KIAA1027
- KREV1
- KSR
- KSR1
- KSR2
- MAP2K1
- MAP2K2
- MAPK1
- MAPK3
- MARK3
- MEK1
- MEK2
- MKK2
- NRAS
- PBP
- PEBP
- PEBP1
- PKS
- PKS2
- PREL1
- PRKM1
- PRKM2
- PRKM3
- PRKMK1
- PRKMK2
- RAF
- RAF1
- RAFB1
- RAP1A
- RAP1B
- RARP1
- RIAM
- SRC
- SRC1
- TLN
- TLN1
- VCL
- VWF
- YWHAB
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Homo sapiens (human)
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MAP2K and MAPK activation
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- APBB1IP
- ARAF
- ARAF1
- ARB2
- ARR1
- ARR2
- ARRB1
- ARRB2
- BRAF
- BRAF1
- CNK1
- CNK2
- CNKSR1
- CNKSR2
- CSK
- CTAK1
- EMK2
- ERK1
- ERK2
- F8VWF
- FGA
- FGB
- FGG
- FN
- FN1
- GP2B
- GP3A
- HRAS
- HRAS1
- IL17RD
- IL17RLM
- IQGAP1
- ITGA2B
- ITGAB
- ITGB3
- KIAA0051
- KIAA0902
- KIAA1027
- KREV1
- KSR
- KSR1
- KSR2
- LAMTOR2
- LAMTOR3
- MAP2K1
- MAP2K1IP1
- MAP2K2
- MAPBPIP
- MAPK1
- MAPK3
- MAPKSP1
- MARK3
- MEK1
- MEK2
- MKK2
- MORG1
- NRAS
- PBP
- PEBP
- PEBP1
- PKS
- PKS2
- PREL1
- PRKM1
- PRKM2
- PRKM3
- PRKMK1
- PRKMK2
- RAF
- RAF1
- RAFB1
- RAP1A
- RAP1B
- RARP1
- RIAM
- ROBLD3
- SEF
- SRC
- SRC1
- TLN
- TLN1
- VCL
- VWF
- WDR83
- YWHAB
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Homo sapiens (human)
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SHC-related events triggered by IGF1R
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- HRAS
- HRAS1
- IBP1
- IGF1
- IGF1R
- IGF2
- NRAS
- SOS1
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Homo sapiens (human)
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Insulin receptor signalling cascade
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- GRB10
- GRBIR
- HRAS
- HRAS1
- INS
- INSR
- KIAA0207
- NRAS
- SHC
- SHC1
- SHCA
- SOS1
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Homo sapiens (human)
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Signalling to RAS
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- HRAS
- HRAS1
- MTC
- NGF
- NGFB
- NRAS
- NSHC
- NTRK1
- SCK
- SHC
- SHC1
- SHC2
- SHC3
- SHCA
- SHCB
- SHCC
- SOS1
- TRK
- TRKA
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Homo sapiens (human)
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Signaling by RAS GTPase mutants
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- HRAS
- HRAS1
- KRAS
- KRAS2
- NRAS
- RASK2
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Homo sapiens (human)
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Signaling by RAS GAP mutants
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- HRAS
- HRAS1
- KRAS
- KRAS2
- NRAS
- RASK2
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Homo sapiens (human)
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Binding of TCF/LEF:CTNNB1 to target gene promoters
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- AML2
- AXIN2
- BHLHE39
- CBFA3
- CTNNB
- CTNNB1
- LEF1
- MYC
- PEBP2A3
- RUNX3
- TCF1
- TCF3
- TCF4
- TCF7
- TCF7L1
- TCF7L2
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Homo sapiens (human)
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RUNX3 regulates WNT signaling
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- AML2
- BCL1
- BHLHE39
- CBFA3
- CCND1
- CTNNB
- CTNNB1
- LEF1
- MYC
- PEBP2A3
- PRAD1
- RUNX3
- TCF1
- TCF3
- TCF4
- TCF7
- TCF7L1
- TCF7L2
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Homo sapiens (human)
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Transcription of E2F targets under negative control by DREAM complex
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- BARA
- BHLHD4
- BHLHE39
- C14orf46
- CDC18L
- CDC25A
- CDC6
- CXCDC1
- DP1
- DP2
- E2F1
- E2F4
- E2F5
- HDAC1
- KIAA2037
- LIN37
- LIN52
- LIN54
- LIN9
- MAX
- MYC
- PCNA
- RB2
- RBAP48
- RBBP3
- RBBP4
- RBL1
- RBL2
- RPD3L1
- TFDP1
- TFDP2
- TGS
- TOP2
- TOP2A
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Homo sapiens (human)
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Cyclin A:Cdk2-associated events at S phase entry
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- AKT1
- AKT2
- AKT3
- BARA
- BHLHD4
- BHLHE39
- C14orf46
- CABLES
- CABLES1
- CAK
- CAK1
- CAP20
- CAP35
- CCN1
- CCNA
- CCNA1
- CCNA2
- CCNH
- CDC25A
- CDC25B
- CDC25HU2
- CDH1
- CDK2
- CDK7
- CDKN1
- CDKN1A
- CDKN1B
- CDKN2
- CDKN7
- CIP1
- CXCDC1
- DP1
- DP2
- E2F1
- E2F4
- E2F5
- FYR
- FZR
- FZR1
- KIAA1242
- KIAA2037
- KIP1
- LIN37
- LIN52
- LIN54
- LIN9
- MAT1
- MAX
- MDA6
- MNAT1
- MO15
- MYC
- PIC1
- PKB
- PKBG
- RAC
- RB1
- RB2
- RBAP48
- RBBP3
- RBBP4
- RBL2
- RNF66
- SDI1
- STK1
- TFDP1
- TFDP2
- TGS
- WAF1
- WEE1
- p27
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Homo sapiens (human)
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TFAP2 (AP-2) family regulates transcription of cell cycle factors
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- AP2TF
- BHLHE39
- CAP20
- CDKN1
- CDKN1A
- CIP1
- JARID1B
- KDM5B
- MDA6
- MYC
- PIC1
- PLU1
- RBBP2H1
- SDI1
- TFAP2
- TFAP2A
- TFAP2C
- WAF1
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Homo sapiens (human)
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Activation of the AP-1 family of transcription factors
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- ATF2
- CREB2
- CREBP1
- CSBP
- CSBP1
- CSBP2
- CSPB1
- ERK1
- ERK2
- FOS
- G0S7
- JNK1
- JNK2
- JNK3
- JNK3A
- JUN
- MAPK1
- MAPK10
- MAPK11
- MAPK14
- MAPK3
- MAPK8
- MAPK9
- MXI2
- PRKM1
- PRKM10
- PRKM11
- PRKM2
- PRKM3
- PRKM8
- PRKM9
- SAPK1
- SAPK1A
- SAPK1B
- SAPK1C
- SAPK2
- SAPK2A
- SAPK2B
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Homo sapiens (human)
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Terminal pathway of complement
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- APOJ
- C5
- C6
- C7
- C8A
- C8B
- C8G
- C9
- CLI
- CLU
- CPAMD4
- KUB1
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Homo sapiens (human)
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Erythrocytes take up oxygen and release carbon dioxide
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- AE1
- AQP1
- CA1
- CA2
- CA4
- CHIP28
- DI
- EPB3
- HBA1
- HBA2
- HBB
- RH50
- RHAG
- SLC4A1
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Homo sapiens (human)
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Erythrocytes take up carbon dioxide and release oxygen
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- AE1
- AQP1
- CA1
- CA2
- CA4
- CHIP28
- CYB5R1
- CYB5R2
- CYB5R4
- CYB5RL
- DI
- EPB3
- HBA1
- HBA2
- HBB
- NCB5OR
- NQO3A2
- RH50
- RHAG
- SLC4A1
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Homo sapiens (human)
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Defective ADA disrupts (deoxy)adenosine deamination
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Homo sapiens (human)
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