GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **851 - 875** of **2090** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism
PI5P Regulates TP53 Acetylation	Cellular tumor antigen p53 Dual specificity mitogen-activated protein kinase kinase 6 Histone acetyltransferase p300 Inhibitor of growth protein 2 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase	P04637 P48426 P52564 P78356 Q09472 Q13526 Q86T03 Q8TBX8 Q9H160	C14orf9 EP300 ING1L ING2 MAP2K6 MEK6 MKK6 P300 P53 PI5P4KA PIN1 PIP4K2A PIP4K2B PIP4K2C PIP4P1 PIP5K2 PIP5K2A PIP5K2B PIP5K2C PRKMK6 SKK3 TMEM55B TP53	Homo sapiens (human)
PI3K/AKT activation	Beta-nerve growth factor High affinity nerve growth factor receptor Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Transforming protein RhoA	O00459 P01138 P04629 P27986 P35568 P42336 P42338 P61586 Q9Y4H2	ARH12 ARHA GRB1 IRS1 IRS2 MTC NGF NGFB NTRK1 PIK3C1 PIK3CA PIK3CB PIK3R1 PIK3R2 RHO12 RHOA TRK TRKA	Homo sapiens (human)
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Acyl-coenzyme A thioesterase THEM4 Amphiregulin B-lymphocyte antigen CD19 Beta-klotho Epidermal growth factor receptor Epigen Estrogen receptor beta Estrogen receptor Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-like 1 Interleukin-33 Mast/stem cell growth factor receptor Kit Membrane protein Myeloid differentiation primary response protein MyD88 Nucleoprotein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Phosphoinositide 3-kinase adapter protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Proline-rich protein 5 Proto-oncogene tyrosine-protein kinase Src Proto-oncogene vav Protransforming growth factor alpha RAC-alpha serine/threonine-protein kinase RAC-beta serine/threonine-protein kinase RAC-gamma serine/threonine-protein kinase Rapamycin-insensitive companion of mTOR Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Receptor tyrosine-protein kinase erbB-2 Receptor-type tyrosine-protein kinase FLT3 Rho-related GTP-binding protein RhoG Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase mTOR Striatin T-cell receptor-associated transmembrane adapter 1 T-cell-specific surface glycoprotein CD28 T-lymphocyte activation antigen CD80 T-lymphocyte activation antigen CD86 TNF receptor-associated factor 6 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tribbles homolog 3 Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11	O00141 O00329 O00459 O14511 O14944 O15520 O15530 O43320 O43815 O76093 O95750 O95760 P00533 P01127 P01133 P01135 P03372 P04626 P05230 P06239 P06241 P08581 P08620 P09038 P09619 P0DTC5 P0DTC9 P10721 P10747 P10767 P11487 P12931 P14210 P15153 P15391 P15498 P15514 P16234 P21781 P22455 P27986 P31371 P31749 P31751 P33681 P35070 P35568 P36888 P42081 P42336 P42338 P42345 P49771 P51617 P56975 P63000 P84095 P85299 Q01638 Q02297 Q06124 Q13480 Q5T1C6 Q6PIZ9 Q6R327 Q6UW88 Q6ZUJ8 Q86Z14 Q8WU20 Q8WWG1 Q92569 Q92731 Q96RU7 Q99075 Q99836 Q9BPZ7 Q9BVC4 Q9GZV9 Q9HCT0 Q9NP95 Q9NWZ3 Q9UQC2 Q9Y243 Q9Y4H2 Q9Y4K3	AKT1 AKT2 AKT3 AREG AREGB ARHG BCAP BTC C20orf97 C9orf26 CD135 CD19 CD28 CD28LG CD28LG1 CD28LG2 CD80 CD86 CTMP DER4 DTR DTS EGF EGFR EPGN ERBB ERBB1 ERBB2 EREG ESR ESR1 ESR2 ESTRB FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRAP FRAP1 FRAP2 FRS2 FYN GAB1 GAB2 GBL GGF GRB1 HBEGF HEGFL HER1 HER2 HGF HGL HPTA HRGA HST HST2 HSTF1 HSTF2 HYPF IL1F11 IL1RL1 IL33 INT2 IRAK IRAK1 IRAK4 IRS1 IRS2 JTK2 KGF KIAA0571 KIAA1999 KIT KLB KS3 LAB7 LCK LST8 M MAPKAP1 MET MIP1 MLN19 MLST8 MTOR MYD88 N NDF NEU NFHEV NGL NIPK NR3A1 NR3A2 NRG1 NRG2 NRG3 NRG4 NTAK PDGF2 PDGFB PDGFR PDGFR1 PDGFR2 PDGFRA PDGFRB PDK1 PDPK1 PIK3AP1 PIK3C1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKB PKBG PROTOR1 PRR5 PTP2C PTPN11 RAC RAC1 RAC2 RAFT1 RAPT1 RHEPDGFRA RHOG RICTOR RNF85 SCFR SDGF SGK SGK1 SHPTP2 SIN1 SIS SKIP3 SMDF SRC SRC1 ST2 STK1 STRN T1 TC25 TCRIM TGFA THEM4 TKF TRAF6 TRAT1 TRB3 TRIB3 VAV VAV1	Homo sapiens (human)
PI3K events in ERBB4 signaling	Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor	O14511 O14944 P27986 P35070 P42336 P56975 Q02297 Q8WWG1 Q99075	BTC DTR DTS EREG GGF GRB1 HBEGF HEGFL HGL HRGA NDF NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 SMDF	Homo sapiens (human)
PI3K events in ERBB2 signaling	Epidermal growth factor receptor GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Pro-neuregulin-3, membrane-bound isoform Pro-neuregulin-4, membrane-bound isoform Probetacellulin Proepiregulin Proheparin-binding EGF-like growth factor Receptor tyrosine-protein kinase erbB-2	O14511 O14944 P00533 P01133 P04626 P27986 P35070 P42336 P56975 Q02297 Q13480 Q8WWG1 Q99075	BTC DTR DTS EGF EGFR ERBB ERBB1 ERBB2 EREG GAB1 GGF GRB1 HBEGF HEGFL HER1 HER2 HGL HRGA MLN19 NDF NEU NGL NRG1 NRG2 NRG3 NRG4 NTAK PIK3CA PIK3R1 SMDF	Homo sapiens (human)
PI3K Cascade	Beta-klotho Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fms-related tyrosine kinase 3 ligand GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 4 Receptor-type tyrosine-protein kinase FLT3 Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type 11	O00459 O15520 O43320 O76093 O95750 P05230 P08620 P09038 P10767 P11487 P21781 P22455 P27986 P31371 P35568 P36888 P42336 P42338 P49771 Q06124 Q13480 Q86Z14 Q8NEB9 Q8WU20 Q99570 Q9GZV9 Q9HCT0 Q9NP95 Q9NR96 Q9UQC2 Q9Y4H2	CD135 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FGFR4 FLK2 FLT3 FLT3LG FRS2 GAB1 GAB2 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 IRS1 IRS2 JTK2 KGF KIAA0571 KLB KS3 PIK3C1 PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTP2C PTPN11 SHPTP2 STK1 TKF TLR9 VPS15 VPS34	Homo sapiens (human)
PI-3K cascade:FGFR4	Beta-klotho Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 19 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O43320 O76093 O95750 P05230 P08620 P09038 P10767 P22455 P27986 P31371 P42336 Q06124 Q13480 Q86Z14 Q8WU20 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF9 FGFA FGFB FGFR4 FRS2 GAB1 GRB1 HST HST2 HSTF1 HSTF2 HYPF JTK2 KLB KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2 TKF	Homo sapiens (human)
PI-3K cascade:FGFR3	Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 4 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O43320 O76093 P05230 P08620 P09038 P27986 P31371 P42336 Q06124 Q13480 Q8WU20 Q9GZV9 Q9NP95	FGF1 FGF16 FGF18 FGF2 FGF20 FGF23 FGF4 FGF9 FGFA FGFB FRS2 GAB1 GRB1 HST HSTF1 HYPF KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2	Homo sapiens (human)
PI-3K cascade:FGFR2	Fibroblast growth factor 10 Fibroblast growth factor 16 Fibroblast growth factor 18 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 7 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O15520 O43320 O76093 P05230 P08620 P09038 P10767 P11487 P21781 P27986 P31371 P42336 Q06124 Q13480 Q8WU20 Q9GZV9 Q9HCT0 Q9NP95	FGF1 FGF10 FGF16 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF7 FGF9 FGFA FGFB FRS2 GAB1 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 KGF KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2	Homo sapiens (human)
PI-3K cascade:FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 20 Fibroblast growth factor 22 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor 4 Fibroblast growth factor 6 Fibroblast growth factor 9 Fibroblast growth factor receptor substrate 2 GRB2-associated-binding protein 1 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Tyrosine-protein phosphatase non-receptor type 11	O15520 P05230 P08620 P09038 P10767 P11487 P27986 P31371 P42336 Q06124 Q13480 Q8WU20 Q9GZV9 Q9HCT0 Q9NP95	FGF1 FGF10 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF6 FGF9 FGFA FGFB FRS2 GAB1 GRB1 HST HST2 HSTF1 HSTF2 HYPF INT2 KS3 PIK3CA PIK3R1 PTP2C PTPN11 SHPTP2	Homo sapiens (human)
PI and PC transport between ER and Golgi membranes	Phosphatidylinositol transfer protein beta isoform	P48739	PITPNB	Homo sapiens (human)
PI Metabolism	Tumor necrosis factor alpha-induced protein 8-like protein 1 Tumor necrosis factor alpha-induced protein 8-like protein 2 Tumor necrosis factor alpha-induced protein 8-like protein 3 Tumor necrosis factor alpha-induced protein 8	O95379 Q5GJ75 Q6P589 Q8WVP5	TIPE3 TNFAIP8 TNFAIP8L1 TNFAIP8L2 TNFAIP8L3	Homo sapiens (human)
PERK regulates gene expression	Cyclic AMP-dependent transcription factor ATF-4 Endoplasmic reticulum chaperone BiP Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3 Eukaryotic translation initiation factor 2-alpha kinase 3	P05198 P11021 P18848 P20042 P41091 Q9NZJ5	ATF4 CREB2 EIF2A EIF2AK3 EIF2B EIF2G EIF2S1 EIF2S2 EIF2S3 GRP78 HSPA5 PEK PERK TXREB	Homo sapiens (human)
PECAM1 interactions	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Integrin alpha-V Integrin beta-3 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Platelet endothelial cell adhesion molecule Tyrosine-protein kinase Fyn Tyrosine-protein kinase Lck Tyrosine-protein kinase Lyn Tyrosine-protein kinase Yes Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	P05106 P06239 P06241 P06756 P07947 P07948 P16284 P19174 P29350 Q06124 Q92835	FYN GP3A HCP INPP5D ITGAV ITGB3 JTK8 LCK LYN MSK8 PECAM1 PLC1 PLCG1 PTP1C PTP2C PTPN11 PTPN6 SHIP SHIP1 SHPTP2 VNRA VTNR YES YES1	Homo sapiens (human)
PDH complex synthesizes acetyl-CoA from PYR	Dihydrolipoyl dehydrogenase, mitochondrial Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial	O00330 P08559 P09622 P10515 P11177 P29803	DLAT DLD DLTA GCSL LAD PDHA1 PDHA2 PDHAL PDHB PDHX PDX1 PHE1A PHE1B PHE3	Homo sapiens (human)
PDGFR mutants bind TKIs	Platelet-derived growth factor receptor alpha	P16234	PDGFR2 PDGFRA RHEPDGFRA	Homo sapiens (human)
PDE3B signalling	RAC-beta serine/threonine-protein kinase cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	P31751 Q13370	AKT2 PDE3B	Homo sapiens (human)
PD-1 signaling	HLA class II histocompatibility antigen, DP alpha 1 chain HLA class II histocompatibility antigen, DP beta 1 chain HLA class II histocompatibility antigen, DQ alpha 1 chain HLA class II histocompatibility antigen, DQ alpha 2 chain HLA class II histocompatibility antigen, DQ beta 1 chain HLA class II histocompatibility antigen, DQ beta 2 chain HLA class II histocompatibility antigen, DR alpha chain HLA class II histocompatibility antigen, DR beta 3 chain HLA class II histocompatibility antigen, DR beta 4 chain HLA class II histocompatibility antigen, DR beta 5 chain HLA class II histocompatibility antigen, DRB1 beta chain Programmed cell death 1 ligand 1 Programmed cell death 1 ligand 2 Programmed cell death protein 1 T cell receptor alpha chain constant T cell receptor alpha variable 19 T cell receptor alpha variable 29/delta variable 5 T cell receptor alpha variable 8-4 T cell receptor beta constant 1 T cell receptor beta variable 12-3 T cell receptor beta variable 7-9 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase CSK Tyrosine-protein kinase Lck Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 6	A0A0A6YYK7 P01730 P01733 P01737 P01848 P01850 P01903 P01906 P01909 P01911 P01920 P04234 P04435 P04437 P04440 P05538 P06239 P07766 P09693 P13762 P20036 P29350 P41240 P79483 Q06124 Q15116 Q30154 Q9BQ51 Q9NZQ7	B7DC B7H1 CD273 CD274 CD3D CD3E CD3G CD4 CSK HCP HLA-DP1A HLA-DP1B HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRA1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-DXA HLA-DXB HLASB LCK PD1 PDCD1 PDCD1L1 PDCD1L2 PDCD1LG1 PDCD1LG2 PDL1 PDL2 PTP1C PTP2C PTPN11 PTPN6 SHPTP2 T3D T3E T3G TCRA TCRBV12S3 TCRBV8S1 TRAC TRAV19 TRAV29DV5 TRAV8-4 TRBC1 TRBV12-3 TRBV7-9	Homo sapiens (human)
PCP/CE pathway	Disheveled-associated activator of morphogenesis 1 Frizzled-1 Frizzled-3 Frizzled-6 Frizzled-7 Profilin-1 Protein Wnt-11 Protein Wnt-4 Protein Wnt-5a Protein Wnt-5b Proto-oncogene Wnt-1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 2 Ras-related C3 botulinum toxin substrate 3 Segment polarity protein dishevelled homolog DVL-1 Segment polarity protein dishevelled homolog DVL-2 Segment polarity protein dishevelled homolog DVL-3 Transforming protein RhoA Tyrosine-protein kinase RYK Tyrosine-protein kinase transmembrane receptor ROR2 Vang-like protein 2	O14640 O14641 O60353 O75084 O96014 P04628 P07737 P15153 P34925 P41221 P56705 P60763 P61586 P63000 Q01974 Q92997 Q9H1J7 Q9NPG1 Q9ULK5 Q9UP38 Q9Y4D1	ARH12 ARHA DAAM1 DVL1 DVL2 DVL3 FZD1 FZD3 FZD6 FZD7 INT1 JTK5A KIAA0208 KIAA0666 KIAA1215 NTRKR2 PFN1 RAC1 RAC2 RAC3 RHO12 RHOA ROR2 RYK STB1 TC25 VANGL2 WNT1 WNT11 WNT4 WNT5A WNT5B	Homo sapiens (human)
PCNA-Dependent Long Patch Base Excision Repair	DNA ligase 1 DNA polymerase beta DNA polymerase delta catalytic subunit DNA polymerase delta subunit 2 DNA polymerase delta subunit 3 DNA polymerase delta subunit 4 DNA polymerase epsilon catalytic subunit A DNA polymerase epsilon subunit 2 DNA polymerase epsilon subunit 3 DNA polymerase epsilon subunit 4 DNA repair nuclease/redox regulator APEX1 Flap endonuclease 1 Proliferating cell nuclear antigen Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 Replication factor C subunit 5 Replication protein A 14 kDa subunit Replication protein A 32 kDa subunit Replication protein A 70 kDa DNA-binding subunit	P06746 P12004 P15927 P18858 P27694 P27695 P28340 P35244 P35249 P35250 P35251 P39748 P40937 P40938 P49005 P56282 Q07864 Q15054 Q9HCU8 Q9NR33 Q9NRF9	APE APE1 APEX APEX1 APX CHRAC17 DPE2 FEN1 HAP1 KIAA0039 LIG1 PCNA POLB POLD POLD1 POLD2 POLD3 POLD4 POLDS POLE POLE1 POLE2 POLE3 POLE4 RAD2 REF1 REPA1 REPA2 REPA3 RFC1 RFC140 RFC2 RFC3 RFC4 RFC5 RPA1 RPA14 RPA2 RPA3 RPA32 RPA34 RPA70	Homo sapiens (human)
P2Y receptors	Lysophosphatidic acid receptor 4 Lysophosphatidic acid receptor 6 P2Y purinoceptor 11 P2Y purinoceptor 12 P2Y purinoceptor 13 P2Y purinoceptor 14 P2Y purinoceptor 1 P2Y purinoceptor 2 P2Y purinoceptor 4 P2Y purinoceptor 6 Putative P2Y purinoceptor 10 Uracil nucleotide/cysteinyl leukotriene receptor	O00398 P41231 P43657 P47900 P51582 Q13304 Q15077 Q15391 Q96G91 Q99677 Q9BPV8 Q9H244	GPR105 GPR17 GPR23 GPR86 GPR94 HORK3 KIAA0001 LPA4 LPAR4 LPAR6 NRU P2RU1 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY5 P2RY6 P2RY9	Homo sapiens (human)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	26S proteasome complex subunit SEM1 26S proteasome non-ATPase regulatory subunit 10 26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 12 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 7 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 10B 26S proteasome regulatory subunit 4 26S proteasome regulatory subunit 6A 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-2 E3 ubiquitin-protein ligase RBX1 Egl nine homolog 1 Elongin-B Elongin-C Endothelial PAS domain-containing protein 1 Hypoxia-inducible factor 1-alpha Hypoxia-inducible factor 3-alpha LIM domain-containing protein 1 LIM domain-containing protein ajuba Polyubiquitin-B Polyubiquitin-C Prolyl hydroxylase EGLN2 Prolyl hydroxylase EGLN3 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit alpha-type 8 Proteasome subunit beta type-10 Proteasome subunit beta type-11 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 Proteasome subunit beta type-8 Proteasome subunit beta type-9 Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-conjugating enzyme E2 D2 Ubiquitin-conjugating enzyme E2 D3 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Wilms tumor protein 1-interacting protein von Hippel-Lindau disease tumor suppressor	A5LHX3 A6NIX2 O00231 O00232 O00233 O00487 O14818 O43242 O75832 P0CG47 P0CG48 P17980 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P35998 P40306 P40337 P43686 P48556 P49720 P49721 P51665 P51668 P55036 P60896 P60900 P61077 P61289 P62191 P62195 P62333 P62837 P62877 P62979 P62987 Q06323 Q13200 Q13617 Q14997 Q15008 Q15369 Q15370 Q16401 Q16665 Q8TAA3 Q92530 Q96IF1 Q96KS0 Q99436 Q99460 Q99814 Q9GZT9 Q9H6Z9 Q9UGP4 Q9UL46 Q9UNM6 Q9Y2N7	AJUBA BHLHE17 BHLHE73 BHLHE78 C1orf12 C7orf76 CUL2 DSS1 EGLN1 EGLN2 EGLN3 EIT6 ELOB ELOC EPAS1 HC2 HC3 HC8 HC9 HIF1A HIF2A HIF3A HSPC IFI5111 JUB KIAA0072 KIAA0077 KIAA0107 LIMD1 LMP10 LMP2 LMP7 LMPX LMPY MB1 MCB1 MECL1 MIP224 MOP1 MOP2 MOP7 MOV34L MSS1 NU PASD2 PASD7 PASD8 PFAAP4 POH1 PROS26 PROS27 PROS30 PSC2 PSC3 PSC5 PSC8 PSC9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA7L PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB5i PSMB6 PSMB6i PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PUBC1 RBX1 RING10 RING12 RNF75 ROC1 RPS27A SEM1 SFT SHFDG1 SHFM1 SUG1 SUG2 TBP1 TBP7 TCEB1 TCEB2 TRAP2 UBA52 UBA80 UBB UBC UBC4 UBC5A UBC5B UBC5C UBCEP1 UBCEP2 UBCH4 UBCH5 UBCH5A UBCH5B UBCH5C UBE2D1 UBE2D2 UBE2D3 VHL WTIP X Y Y2 Z	Homo sapiens (human)
Oxidative demethylation of DNA	G/T mismatch-specific thymine DNA glycosylase Methylcytosine dioxygenase TET1 Methylcytosine dioxygenase TET2 Methylcytosine dioxygenase TET3	O43151 Q13569 Q6N021 Q8NFU7	CXXC6 KIAA0401 KIAA1546 KIAA1676 LCX TDG TET1 TET2 TET3	Homo sapiens (human)
Oxidative Stress Induced Senescence	Cellular tumor antigen p53 Chromobox protein homolog 2 Chromobox protein homolog 6 Chromobox protein homolog 8 Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 inhibitor C Cyclin-dependent kinase 4 inhibitor D Cyclin-dependent kinase 4 Cyclin-dependent kinase 6 Cyclin-dependent kinase inhibitor 2A Dual specificity mitogen-activated protein kinase kinase 3 Dual specificity mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 6 Dual specificity mitogen-activated protein kinase kinase 7 E3 SUMO-protein ligase CBX4 E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase RING1 E3 ubiquitin-protein ligase RING2 Helicase MOV-10 Histone H2A type 1-B/E Histone H2A type 1-C Histone H2A type 1-D Histone H2A type 1-J Histone H2A type 2-A Histone H2A type 2-C Histone H2A-Bbd type 1 Histone H2A.J Histone H2A.V Histone H2AX Histone H2B type 1-A Histone H2B type 1-B Histone H2B type 1-C/E/F/G/I Histone H2B type 1-D Histone H2B type 1-H Histone H2B type 1-J Histone H2B type 1-K Histone H2B type 1-L Histone H2B type 1-M Histone H2B type 1-N Histone H2B type 1-O Histone H2B type 2-E Histone H2B type 3-B Histone H2B type F-S Histone H3.1 Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 Interferon beta Lysine-specific demethylase 6B MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 MAP kinase-activated protein kinase 5 Misshapen-like kinase 1 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase kinase kinase 5 Mitogen-activated protein kinase kinase kinase kinase 4 Polycomb complex protein BMI-1 Polycomb protein EED Polycomb protein SUZ12 Polyhomeotic-like protein 1 Polyhomeotic-like protein 2 Polyhomeotic-like protein 3 Polyubiquitin-B Polyubiquitin-C Protein Mdm4 Protein argonaute-1 Protein argonaute-3 Protein argonaute-4 Protein c-Fos TRAF2 and NCK-interacting protein kinase Thioredoxin Transcription factor Dp-1 Transcription factor Dp-2 Transcription factor E2F1 Transcription factor E2F2 Transcription factor E2F3 Transcription factor Jun Trinucleotide repeat-containing gene 6A protein Trinucleotide repeat-containing gene 6B protein Trinucleotide repeat-containing gene 6C protein Tumor suppressor ARF Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O00257 O00716 O14733 O15054 O15151 O60814 O75530 O95503 O95819 P01100 P01574 P04637 P04908 P05412 P06899 P0C5Y9 P0CG47 P0CG48 P10599 P11802 P16104 P20671 P23527 P27361 P28482 P33778 P35226 P42771 P42772 P42773 P45983 P45984 P45985 P46734 P49137 P52564 P53779 P55273 P57053 P58876 P62805 P62807 P62979 P62987 P68431 P78364 P84243 Q00534 Q00987 Q01094 Q06587 Q09028 Q14186 Q14188 Q14209 Q14781 Q15022 Q15759 Q15910 Q16539 Q16576 Q16644 Q16777 Q16778 Q6FI13 Q71DI3 Q71UI9 Q8IW41 Q8IXK0 Q8N257 Q8N4C8 Q8N726 Q8NDV7 Q8NDX5 Q93077 Q93079 Q96A08 Q99496 Q99683 Q99877 Q99878 Q99879 Q99880 Q9BTM1 Q9H9G7 Q9HC52 Q9HCE1 Q9HCJ0 Q9HCK5 Q9UKE5 Q9UL18 Q9UPQ9	AGO1 AGO3 AGO4 ASK1 B55 BAP1 BMI1 CAGH26 CBX2 CBX4 CBX6 CBX8 CDK4 CDK6 CDKN2 CDKN2A CDKN2B CDKN2C CDKN2D CDKN6 CHET9 CSBP CSBP1 CSBP2 CSPB1 DING DP1 DP2 E2F1 E2F2 E2F3 EDR1 EDR2 EDR3 EED EIF2C1 EIF2C3 EIF2C4 ERK1 ERK2 EZH2 FOS G0S7 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AFA H2AFB1 H2AFE H2AFG H2AFJ H2AFL H2AFM H2AFO H2AFQ H2AFV H2AFX H2AJ H2AV H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H2BFA H2BFB H2BFC H2BFD H2BFE H2BFF H2BFG H2BFH H2BFJ H2BFK H2BFL H2BFN H2BFQ H2BFR H2BFS H2BFT H2BS1 H2BU1 H3-3A H3-3B H3.3A H3.3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H3F2 H3F3 H3F3A H3F3B H3FA H3FB H3FC HIST1H3C H3FD H3FF H3FH H3FI H3FJ H3FK H3FL H3FM H4-16 H4/A H4/B H4/C H4/D H4/E H4/G H4/H H4/I H4/J H4/K H4/M H4/N H4/O H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 H4F2 H4FA H4FB H4FC H4FD H4FE H4FG H4FH H4FI H4FJ H4FK H4FM H4FN H4FO HGK HIPI3 HIRIP1 HIRIP2 HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4 HIST2H4A HIST2H4B HIST3H2BB HIST4H4 IFB IFNB IFNB1 JJAZ1 JMJD3 JNK1 JNK2 JNK3 JNK3A JNKK1 JNKK2 JUN KDM6B KIAA0075 KIAA0160 KIAA0346 KIAA0551 KIAA0687 KIAA1093 KIAA1460 KIAA1567 KIAA1582 KIAA1631 KMT6 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K5 MAP4K4 MAP4K6 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPKKK5 MDM2 MDM4 MDMX MEK3 MEK4 MEK6 MEK7 MEKK5 MINK MINK1 MKK3 MKK4 MKK6 MKK7 MLM MOV10 MTS1 MTS2 MXI2 NIK P53 PC3 PCGF4 PH1 PH2 PH3 PHC1 PHC2 PHC3 PRAK PRKM1 PRKM10 PRKM11 PRKM2 PRKM3 PRKM8 PRKM9 PRKMK3 PRKMK4 PRKMK6 PRKMK7 RBAP46 RBAP48 RBBP3 RBBP4 RBBP7 RC1 RING1 RING1A RING1B RNF1 RNF2 RNF51 RPS27A SAPK1 SAPK1A SAPK1B SAPK1C SAPK2 SAPK2A SAPK2B SEK1 SERK1 SKK1 SKK2 SKK3 SKK4 SUZ12 TFDP1 TFDP2 TNIK TNRC6 TNRC6A TNRC6B TNRC6C TP53 TRDX TRX TRX1 TSH2B TXN UBA52 UBA80 UBB UBC UBCEP1 UBCEP2 YSK2 ZC3	Homo sapiens (human)
Ovarian tumor domain proteases	Adenomatous polyposis coli protein Antiviral innate immune response receptor RIG-I Cellular tumor antigen p53 Cyclin-dependent kinase 1 Deubiquitinating protein VCPIP1 E3 ubiquitin-protein ligase RNF128 E3 ubiquitin-protein ligase RNF135 E3 ubiquitin-protein ligase TRIM4 E3 ubiquitin/ISG15 ligase TRIM25 Estrogen receptor Interferon-induced helicase C domain-containing protein 1 Mitochondrial antiviral-signaling protein NF-kappa-B essential modulator Nucleotide-binding oligomerization domain-containing protein 1 Nucleotide-binding oligomerization domain-containing protein 2 OTU domain-containing protein 3 OTU domain-containing protein 5 OTU domain-containing protein 7A OTU domain-containing protein 7B Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Polyubiquitin-B Polyubiquitin-C Receptor-interacting serine/threonine-protein kinase 1 Receptor-interacting serine/threonine-protein kinase 2 TNF receptor-associated factor 3 TNF receptor-associated factor 6 TNFAIP3-interacting protein 1 TNFAIP3-interacting protein 2 TNFAIP3-interacting protein 3 Transforming protein RhoA Transitional endoplasmic reticulum ATPase Tumor necrosis factor alpha-induced protein 3 Ubiquitin thioesterase OTU1 Ubiquitin thioesterase OTUB1 Ubiquitin thioesterase OTUB2 Ubiquitin thioesterase ZRANB1 Ubiquitin-conjugating enzyme E2 D1 Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	O43353 O95786 P03372 P04637 P06493 P0CG47 P0CG48 P21580 P25054 P51668 P55072 P60484 P61586 P62979 P62987 Q13114 Q13546 Q14258 Q15025 Q5T2D3 Q5VVQ6 Q6GQQ9 Q7Z434 Q8IUD6 Q8NFZ5 Q8TE49 Q8TEB7 Q96DC9 Q96FW1 Q96G74 Q96JH7 Q96KP6 Q9BYX4 Q9C037 Q9HC29 Q9UGI0 Q9Y239 Q9Y4K3 Q9Y6K9	ABIN2 ABIN3 APC ARH12 ARHA C14orf137 C15orf16 CAP-1 CARD15 CARD4 CARDIAK CDC2 CDC28A CDK1 CDKN1 CEZANNE2 CRAF1 DDX58 DP2.5 DUBA8 EFP ESR ESR1 FIP3 FLIP1 HEL-220 HEL-S-70 HIN7 IFIH1 IKBKG IPS1 KIAA0113 KIAA0459 KIAA1271 KIAA1850 LIND MAVS MDA5 MMAC1 NAF1 NEMO NOD1 NOD2 NR3A1 OTB1 OTB2 OTU1 OTU2 OTUB1 OTUB2 OTUD2 OTUD3 OTUD5 OTUD7 OTUD7A OTUD7B OTUD7C P34CDC2 P53 PTEN RH116 RHO12 RHOA RICK RIGI RIP RIP1 RIP2 RIPK1 RIPK2 RNF128 RNF135 RNF147 RNF85 RNF87 RPS27A SFT TEP1 TNFAIP3 TNIP1 TNIP2 TNIP3 TP53 TRABID TRAF3 TRAF6 TRAFAMN TRIM25 TRIM4 UBA52 UBA80 UBB UBC UBC5A UBCEP1 UBCEP2 UBCH5 UBCH5A UBE2D1 VCIP135 VCP VCPIP1 VISA YOD1 ZA20D1 ZNF147 ZRANB1	Homo sapiens (human)

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